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J Refract Surg 2019 Feb;35(2):121-125

Purpose: To report the outcomes of a series of 16 patients who had secondary surface ablation within 4 weeks of an aborted femtosecond laser-assisted in situ keratomileusis (FS-LASIK) procedure.

Methods: A retrospective chart review of electronic medical record data from 2011 to 2015 was performed to identify eyes of patients who had an aborted FS-LASIK procedure followed by secondary surface ablation (photorefractive keratectomy or laser epithelial keratomileusis) within 4 weeks of the primary procedure. Patients were required to have at least three postoperative visits to be included in the study. Read More

BMC Womens Health 2019 Jan 28;19(1):22. Epub 2019 Jan 28.

Ministry of Health, Community Development, Gender, Elderly and Children (MOHCDGEC), PO Box 9083, Dar es Salaam, Tanzania.

Background: The family planning component of postabortion care (PAC) is critical, as it helps women to prevent unintended pregnancies and reduce future incidence of life-threatening unsafe abortion. In Tanzania, PAC was recently decentralized from tertiary-level district hospitals to primary health care dispensaries in four regions of the country. This analysis describes interventions used to improve access to high quality PAC services during decentralization; examines results and factors that contribute to PAC clients' voluntary uptake of contraception; and develops recommendations for improving postabortion contraceptive services. Read More

Acta Obstet Gynecol Scand 2019 Jan 19. Epub 2019 Jan 19.

Department of Obstetrics and Gynecology, University Hospital Örebro, Örebro, Sweden.

Introduction: Home use of misoprostol for medical abortion is increasingly being practiced. With gestational length up to 70 days, it is considered effective, safe and acceptable by women. Knowledge of safety and efficacy with longer gestations is limited and studies are required to expand women's options to include this method of abortion. Read More

J Family Med Prim Care 2018 Nov-Dec;7(6):1521-1526

Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Background: Sri Lankan abortion law which dates back to the year 1883, and still unchanged, only allows a legal termination when the mother's life is in danger. Many studies undertaken in the country estimates that even in the light of such a backdrop, and with a high contraceptive prevalence rate, many women attempt an abortion when faced with an unwanted pregnancy. This study aims to describe the changes in abortion-related complications in the country over a period of time and explore the reasons for any changes in severity of symptoms among women hospitalized following an abortion based on the perceptions of healthcare service providers. Read More

Eur J Contracept Reprod Health Care 2018 Dec 2;23(6):451-457. Epub 2019 Jan 2.

b Department of Women's and Children's Health, Division of Obstetrics and Gynaecology , Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden.

Objective: Medical termination of pregnancy (MToP, or medical abortion) is a highly effective method with a reported efficacy of 95-98%. However, different criteria are currently used to define success, and there are different recommendations for the treatment of what is considered a failure of MToP. This work was undertaken to develop a consensus around a set of well-defined MToP outcomes, as recommended by the Core Outcomes in Women's and Newborn Health initiative. Read More

PLoS One 2018 31;13(12):e0209415. Epub 2018 Dec 31.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneva, Switzerland.

Objective: The study aimed to assess the use of misoprostol and complications associated with abortions in referral hospitals in Nigeria, a country with restrictive abortion laws.

Methods: A cross-sectional study at nine referral hospitals in South-west Nigeria. Nine years' data were retrieved from medical records, including 699 induced abortions. Read More

Cochrane Database Syst Rev 2018 12 19;12:CD012834. Epub 2018 Dec 19.

Department of International Health, Social and Behavioral Interventions Program, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Suite E5033, Baltimore, Maryland, USA, 21205.

Background: The World Health Organization (WHO) guidelines for safe abortion recommend medical abortion with mifepristone and misoprostol or surgical abortion with vacuum aspiration or dilation and evacuation as safe and effective options for women. However, no specific clinical considerations are stipulated within these guidelines for women living with HIV. Concerns have been raised that women living with HIV may be at greater risk of adverse abortion outcomes compared to HIV-uninfected women due to immunosuppression, high rates of co-infection with other sexually transmitted infections, and possible contraindications between medications used for medical abortion and antiretroviral therapy regimens. Read More

Obstet Gynecol Int 2018 20;2018:3958681. Epub 2018 Sep 20.

School of Public Health, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia.

Background: Each year, several millions of women who underwent abortion also bear several consequences, including infection, massive blood loss, chronic pelvic pain, infertility, and death. Poor treatment outcomes also cause disability and death. The aim of this study was to determine factors associated with management outcomes of incomplete abortion in Yirgalem General Hospital. Read More

BMJ Glob Health 2018 23;3(5):e000823. Epub 2018 Sep 23.

Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.

Introduction: The maternal mortality ratio is decreasing globally, although it remains high in Malawi. Unsafe abortion is a major cause and treatment of complications after abortion is a big burden on the health system. Even though manual vacuum aspiration (MVA) is the recommended surgical treatment of incomplete abortions in the first trimester, many hospitals in Malawi continue to use sharp curettage. Read More

BMC Womens Health 2018 Sep 25;18(1):158. Epub 2018 Sep 25.

Department of Obstetrics and Gynecology, Skaraborg Hospital Skövde, Skövde, Sweden.

Background: Induced abortion is one of the most common gynecological procedures in Sweden, but there is still little knowledge about the adverse effects. The aims of this study are to provide an overview of complications of medical and surgical abortions and to evaluate the impact of bacterial screening to prevent postabortal infections.

Methods: All women who underwent induced abortion at Skaraborg Hospital between 2008 and 2015 are included in the study. Read More

PLoS One 2018 21;13(9):e0204240. Epub 2018 Sep 21.

School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Background: Unsafe abortion is still a leading cause of maternal death in most Sub-Saharan African countries. Post-abortion care (PAC) aims to minimize morbidity and mortality following unsafe abortion, addressing incomplete abortion by treating complications, and reducing possible future unwanted pregnancies by providing contraceptive advice. In this article, we draw on data from PAC service providers and patients in Kenya to illustrate how the quality of PAC in healthcare facilities is impacted by law and government policy. Read More

J Orthop Trauma 2019 Jan;33(1):23-30

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Objective: To determine whether operating on "major" vertebral fractures leads to premature abortion of surgery and/or other acute cardiopulmonary complications.

Design: Retrospective review.

Clinical Setting: Level 1 trauma center. Read More

BMC Pregnancy Childbirth 2018 Sep 5;18(1):360. Epub 2018 Sep 5.

Department of Obstetrics and Gynecology, KK Women's and Children's Hospital, Singapore, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Background: Progesterone is a critical hormone in early pregnancy. A low level of serum progesterone is associated with threatened miscarriage. We aim to establish the distribution of maternal serum progesterone in normal pregnancies compared to pregnancies complicated by threatened miscarriage from 5 to 13 weeks gestation. Read More

Libyan J Med 2018 Dec;13(1):1508273

c Department of Physiology , Huzhou University , Huzhou , People's Republic of China.

Objectives: Our research investigated the relationship between childhood leukemia and breastfeeding in the P. R. of China. Read More

Bull Exp Biol Med 2018 Aug 18;165(4):581-583. Epub 2018 Aug 18.

V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

Genetic program regulating epithelial-mesenchymal transition is activated at the early stages of embryogenesis. Abnormal karyotype of the embryo disrupts the fundamental process of epithelial-mesenchymal transition, which is seen from incomplete morphological rearrangement and reduced migration capacity of cells, as well as low level of expression of epithelial-mesenchymal transition markers (fibronectin, collagen, and glycosaminoglycans). Disturbances of the epithelial-mesenchymal transition affect the proliferative potential of cells with aberrant karyotype, which contributes to the delay of embryonic development and correlates with the formation of abnormal phenotype in carriers of chromosomal abnormalities. Read More

J Obstet Gynaecol Can 2018 Aug;40(8):1017-1023

Maternal, Newborn and Teen Program, Department of Obstetrics and Gynaecology, North York General Hospital, Toronto, ON; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, ON. Electronic address:

Objective: This study sought to evaluate the sustained value of an early pregnancy assessment clinic (EPAC) in the management of early pregnancy complications and its effect on the incidence emergency room (ER) visits.

Methods: A 10-year retrospective study (January 2006 to December 2015) was conducted. The number of patients assessed, sources and reasons for referral, and treatments provided were reviewed. Read More

Contraception 2018 Dec 7;98(6):541-543. Epub 2018 Aug 7.

Department of Obstetrics and Gynecology, University of California, Davis, Sacramento, CA, USA.

Low but rising serum human chorionic gonadotropin (hCG) levels occur infrequently after an induced abortion. Because this scenario rarely occurs after suction aspiration, clinicians may have higher suspicion for an uncommon diagnosis. The differential diagnosis includes both common and uncommon diagnoses, such as incomplete abortion, heterotopic or ectopic pregnancy, a new intrauterine pregnancy and gestational trophoblastic neoplasia. Read More

PLoS One 2018 10;13(8):e0201214. Epub 2018 Aug 10.

College of Health Sciences, School of Nursing Sciences, University of Nairobi, Nairobi, Kenya.

Aim: The aim was to explore contraceptive uptake, associated factors and satisfaction among post abortion-care (PAC) seeking women in Kenya. Due to unsafe abortions, almost 120 000 Kenyan women received PAC in 2012, and of these women, 70% did not use contraception before pregnancy.

Methods: This study was nested in a larger randomised controlled trial, where 859 women sought PAC at two public hospitals in Kisumu, in June 2013-May 2016. Read More

J Obstet Gynaecol Res 2018 Dec 29;44(12):2174-2180. Epub 2018 Jul 29.

Department of Obstetrics and Gynecology, El-Galaa Maternity Teaching Hospital, Cairo, Egypt.

Aim: The aim of this work is to assess the effectiveness of hysteroscopic tubal occlusion using iso-amyl-2-cyanoacrylate, among infertile women with hydrosalpinx prior to in vitro fertilization (IVF).

Methods: Hysteroscopic injection of fallopian tubes with hydrosalpinx by 0.5 mL iso-amyl-2-cyanoacrylate was done in 40 infertile women planning for IVF. Read More

Acta Trop 2018 Nov 25;187:37-43. Epub 2018 Jul 25.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China. Electronic address:

Bovine herpesvirus 1 (BHV-1), an important pathogen of cattle, can cause severe clinical syndromes including respiratory disease, genital disease, and late-term abortions, as well as neurological and systemic disease in cattle. For assessing the prevalence of BHV-1 infection in mainland China, a systematic review and meta-analysis was conducted. In this systematic review and meta-analysis, we searched English and Chinese literature databases for published paper regarding the prevalence of BHV-1 in cattle in China from inception to May 20, 2018. Read More

BMJ Sex Reprod Health 2018 May 31. Epub 2018 May 31.

Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia, USA.

Objective: Although illegal abortion is believed to be widely practised in Haiti, few data exist on such practices. We aimed to learn about illegal abortion access, methods, and perceived barriers to abortion-related care. Additionally, we aimed to identify the proportion of unscheduled antepartum visits to a public hospital that were attributable to unsafe abortion in Cap Haitien, Haiti. Read More

J Obstet Gynaecol Res 2018 Aug 28;44(8):1482-1486. Epub 2018 Jun 28.

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Retained products of conception with marked vascularity can cause massive postabortal or post-partum bleeding. Uterine artery embolization is effective for uterus preservation but does not assure fertility preservation. Thus, the optimal treatment for retained products of conception with marked vascularity is uncertain. Read More

Fertil Steril 2018 06;109(6):1060-1064

Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.

Objective: To determine if alpha-fetoprotein (AFP) concentration in vaginal blood, in the setting of dissolved fetal tissue, is significantly higher than its concentration in the maternal serum.

Design: A prospective cohort study.

Setting: Medical center. Read More

Nat Commun 2018 05 14;9(1):1873. Epub 2018 May 14.

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands.

In contrast to mouse, human female germ cells develop asynchronously. Germ cells transition to meiosis, erase genomic imprints, and reactivate the X chromosome. It is unknown if these events all appear asynchronously, and how they relate to each other. Read More

J Med Internet Res 2018 May 14;20(5):e186. Epub 2018 May 14.

Advancing New Standards in Reproductive Health, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, Oakland, CA, United States.

Background: Abortion is a common medical procedure, yet its availability has become more limited across the United States over the past decade. Women who do not know where to go for abortion care may use the internet to find abortion facility information, and there appears to be more online searches for abortion in states with more restrictive abortion laws. While previous studies have examined the distances women must travel to reach an abortion provider, to our knowledge no studies have used a systematic online search to document the geographic locations and services of abortion facilities. Read More

J Matern Fetal Neonatal Med 2018 May 9:1-5. Epub 2018 May 9.

a Faculty of Medicine , Zagazig University , Zagazig , Egypt.

Purpose: To compare between low dose vaginal misoprostol with and without Foley catheter for late second trimester pregnancy termination in women with previous multiple cesarean sections.

Materials And Methods: A prospective randomized controlled clinical trial, patients were randomly allocated to either low dose vaginal misoprostol group (n = 40) or combined low dose vaginal misoprostol plus Foley catheter group (n = 38). The primary outcome was complete abortion. Read More

Chem Pharm Bull (Tokyo) 2018 Jul 14;66(7):708-713. Epub 2018 Apr 14.

School of Pharmacy, Anhui University of Chinese Medicine.

Abnormal uterine bleeding (AUB) induced by incomplete abortion is a common gynecological disease. Taohong Siwu decoction (TSD) is a traditional Chinese medicine (TCM) formula, which has been developed to treat AUB for hundreds of years. In this study, rats had incomplete abortion induced in early pregnancy using mifepristone and misoprostol. Read More

Mol Genet Genomic Med 2018 05 24;6(3):370-381. Epub 2018 Mar 24.

Dr. Lal PathLabs Ltd., New Delhi, India.

Background: Karyotype determination has a central role in the genetic workup of pregnancy loss, as aneuploidy (trisomy and monosomy) and polyploidy (triploidy and tetraploidy) are the cause in at least 50% of first trimester, 25% of second trimester, and 11% of third trimester miscarriages. There are several limitations with the current approaches of obtaining a karyotype using traditional cytogenetics, fluorescence in situ hybridization with a limited number of probes, and chromosomal microarray. These include culture failure, incomplete results, lower sensitivity, and longer reporting time. Read More

Obstet Gynecol Sci 2018 Mar 2;61(2):220-226. Epub 2018 Mar 2.

Department of Obstetrics and Gynecology, Seoul Metropolitan-Government Seoul National University Boramae Medical Center, Seoul, Korea.

Objective: This study was conducted to determine the effectiveness and safety of medical treatment with sublingual misoprostol (MS) in the 1st trimester miscarriage under the approval by Health Insurance Review and Assessment Service (HIRA) for off-label usage by the single medical center in Korea.

Methods: A retrospective cohort study was performed in one institution between April 2013 and June 2016. Ninety-one patients diagnosed with miscarriage before 14 weeks of gestation and wanted to try medical treatment were included. Read More

Hum Reprod 2018 04;33(4):579-587

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Memphis, TN 38120, USA.

Study Question: Will the addition of 24-chromosome microarray analysis on miscarriage tissue combined with the standard American Society for Reproductive Medicine (ASRM) evaluation for recurrent miscarriage explain most losses?

Summary Answer: Over 90% of patients with recurrent pregnancy loss (RPL) will have a probable or definitive cause identified when combining genetic testing on miscarriage tissue with the standard ASRM evaluation for recurrent miscarriage.

What Is Known Already: RPL is estimated to occur in 2-4% of reproductive age couples. A probable cause can be identified in approximately 50% of patients after an ASRM recommended workup including an evaluation for parental chromosomal abnormalities, congenital and acquired uterine anomalies, endocrine imbalances and autoimmune factors including antiphospholipid syndrome. Read More

J Minim Invasive Gynecol 2019 Jan 7;26(1):29-30. Epub 2018 Mar 7.

Department of Obstetrics and Gynecology, Nova Medical School, Faculdade de Ciências Médicas, Nova University of Lisbon, Lisbon, Portugal; Department of Obstetrics and Gynecology, Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal. Electronic address:

Study Objective: To present and discuss the hysteroscopic aspects of incarcerated omentum through uterine perforation caused by previous dilation and curettage (D&C) for an incomplete first-trimester abortion.

Design: A case report.

Setting: Constantine University Hospital, Constantine, Algeria. Read More

Int J Environ Res Public Health 2018 02 21;15(2). Epub 2018 Feb 21.

Department of Public Health and Nursing, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.

Malawi has a high maternal mortality rate, of which unsafe abortion is a major cause. About 140,000 induced abortions are estimated every year, despite there being a restrictive abortion law in place. This leads to complications, such as incomplete abortions, which need to be treated to avoid further harm. Read More

BMC Womens Health 2018 02 17;18(1):41. Epub 2018 Feb 17.

African Population and Health Research Center, 2nd Floor APHRC Campus, Manga Close Off Kirawa Road, P.O. Box 10787-00100, Nairobi, Kenya.

Background: Complications of unsafe abortion are a leading cause of maternal mortality in sub-Saharan Africa. Adolescents and young women are disproportionately represented among those at risk of these complications. Currently, we know little about the factors associated with young women's timing of abortion. Read More

PLoS One 2018 7;13(2):e0192301. Epub 2018 Feb 7.

Virology Unit, The Irish Equine Centre, Johnstown, Naas, County Kildare, Ireland.

Equid herpesvirus 8 (EHV-8), formerly known as asinine herpesvirus 3, is an alphaherpesvirus that is closely related to equid herpesviruses 1 and 9 (EHV-1 and EHV-9). The pathogenesis of EHV-8 is relatively little studied and to date has only been associated with respiratory disease in donkeys in Australia and horses in China. A single EHV-8 genome sequence has been generated for strain Wh in China, but is apparently incomplete and contains frameshifts in two genes. Read More

J Exp Bot 2018 Mar;69(6):1403-1414

Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, Versailles, France.

Autophagy is essential for nutrient recycling and plays a fundamental role in seed production and grain filling in plants. Autophagy participates in nitrogen remobilization at the whole-plant level, and the seeds of autophagy mutants present abnormal C and N contents relative to wild-type (WT) plants. It is well known that autophagy (ATG) genes are induced in leaves during senescence; however, expression of such genes in seeds has not yet been reported. Read More

Zhonghua Yi Xue Za Zhi 2018 Jan;98(3):217-221

Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China.

To evaluate the value of hysteroscopy in the diagnosis and treatment of cesarean scar pregnancy (CSP) incomplete abortion. A total of 42 patients with incomplete cesarean circumcision from January 2014 to March 2017 were retrospectively analyzed.Twenty-one patients underwent bilateral uterine artery embolization. Read More

PLoS One 2018 19;13(1):e0191174. Epub 2018 Jan 19.

Bixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California San Francisco, San Francisco, CA, United States of America.

Background: Expanding access to medication abortion through pharmacies is a promising avenue to reach women with safe and convenient care, yet no pharmacy provision interventions have been evaluated. This observational non-inferiority study investigated the effectiveness and safety of mifepristone-misoprostol medication abortion provided at pharmacies, compared to government-certified public health facilities, by trained auxiliary nurse-midwives in Nepal.

Methods: Auxiliary nurse-midwives were trained to provide medication abortion through twelve pharmacies and public facilities as part of a demonstration project in two districts. Read More

World J Surg 2018 03;42(3):639-645

Department of Endocrine and Thyroid Surgery, Hammersmith Hospital, Imperial College London, London, UK.

Background: Primary hyperparathyroidism (pHPT) in pregnancy is reported to be associated with significant maternal and foetal complications and an up to threefold increase in the risk of miscarriage. However, the true incidence of pHPT in pregnancy, complete and miscarried, is unknown and there are no data on the prevalence of undiagnosed pHPT in recurrent miscarriage (RM) (≥3 consecutive miscarriages under 24-week gestation). This is the first prospective study aiming to establish the prevalence of undiagnosed pHPT in RM. Read More

Gynecol Endocrinol 2018 Jul 18;34(7):609-611. Epub 2018 Jan 18.

a Department of Obstetrics and Gynecology, TRIO Fertility, Toronto and Division of Reproductive Sciences , University of Toronto , Toronto , Canada.

Many Patients with persistent retained products of conception prefers to avoid surgical interventions, such as a dilatation and curettage (D&C) that might pose an additional future risk to their already compromised fertility or obstetric performance. The aim of this study was to the possibility of induced withdrawal bleeding following oral contraceptive administration as a non-surgical treatment for patients with persistent retained products of conception (RPOC). A retrospective study of patients presenting with retained products of conception (RPOC) after failed expectant management or after treatment with PGE1 was performed. Read More

Acta Obstet Gynecol Scand 2018 Mar 19;97(3):294-300. Epub 2018 Jan 19.

Department of Health Sciences, Faculty of Earth and Life Sciences, Free University Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Introduction: Curettage is more effective than expectant management in women with suspected incomplete evacuation after misoprostol treatment for first-trimester miscarriage. The cost-effectiveness of curettage vs. expectant management in this group is unknown. Read More

Arkh Patol 2017;79(6):30-35

Research Institute of Human Morphology, Moscow, Russia.

Aim: to investigate the characteristics of cytotrophoblast invasion in complete placenta previa and increta.

Material And Methods: Three groups of placentas and amputated uteri were examined. These were: 1) 10 placentas at 20-22 weeks' gestation after drug-induced abortion; 2) 4 uteri with typical placentation at 34-36 weeks and wall ruptures; 3) 12 uteri with ultrasound-confirmed complete placenta previa and subsequent hysterectomy (at 34-36 weeks. Read More

Int Perspect Sex Reprod Health 2017 06 1;43(2):89-98. Epub 2017 Jun 1.

Context: Given that maternal morbidity and mortality from unsafe abortion persist, especially in Africa, there is a pressing need to understand the abortion decision-making process. However, little is known about men's influence on and involvement in women's abortion decision making and care seeking.

Methods: A qualitative study was conducted at the largest public provider of abortion-related care in Zambia. Read More

Int Perspect Sex Reprod Health 2017 06 1;43(2):67-74. Epub 2017 Jun 1.

Johns Hopkins University.

Context: The World Health Organization recommends that contraceptives be offered on the day of a uterine evacuation procedure (i.e., induced abortion or postabortion care for an incomplete abortion). Read More

Malar J 2017 Dec 18;16(1):491. Epub 2017 Dec 18.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.

Background: Considering the uncertainty of safety of anti-malarial drugs in pregnancy, efficacy studies are one of the few sources of clinical safety data. Complete safety evaluation is not usually incorporated in efficacy studies due to financial and human resource constraints. This review reports the methods used for the assessment of safety of artemisinin-based and quinine-based treatments in efficacy studies in pregnancy. Read More

Int J Gynaecol Obstet 2018 Apr 24;141(1):32-36. Epub 2018 Jan 24.

Center for Research in Human Reproduction of Campinas (CEMICAMP), Campinas, Brazil.

Objective: To evaluate long-acting reversible contraceptive (LARC) uptake immediately after abortion at Lusaka University Teaching Hospital, Zambia in the period following an intervention to increase the acceptance of LARC.

Methods: The present retrospective, observational study reviewed the clinical records of all patients admitted to the Lusaka University Teaching Hospital for an incomplete abortion or for a legal induced abortion between January 1 and December 31, 2016. The primary outcome measure was the proportion of adult women (aged 20-44 years) and adolescents (aged 10-19 years) who were already using an available contraceptive method at the time of hospital discharge. Read More

Contraception 2018 02 11;97(2):116-121. Epub 2017 Dec 11.

Institut Pasteur de Madagascar.

Objective: The objective was to learn what complications some women experienced in Madagascar following use of misoprostol for abortion and what treatment they received post misoprostol use.

Study Design: This was a qualitative study in 2015-2016 among women who had experienced complications after use of misoprostol, with or without additional methods, for abortion; what information they received before use; what dosage and regimens they used; what complications they experienced; and what treatment they received postuse. We initially conducted in-depth, semistructured interviews with 60 women who had undergone an abortion that resulted in complications. Read More

Lancet Glob Health 2018 01;6(1):e111-e120

Guttmacher Institute, New York, NY, USA.

Background: Reliable information on the incidence of induced abortion in India is lacking. Official statistics and national surveys provide incomplete coverage. Since the early 2000s, medication abortion has become increasingly available, improving the way women obtain abortions. Read More

Cochrane Database Syst Rev 2017 11 29;11:CD003053. Epub 2017 Nov 29.

Department of Obstetrics and Gynaecology, The General Infirmary of Leeds, United Leeds Teaching Hospitals NHS Trust, Belmont Grove, Leeds, UK, LS2 9NS.

Background: Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with increased risk of cardiovascular disease and diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation. Read More

Curr Drug Saf 2018 ;13(1):65-68

Pharmaceutical Care Department, King Abdul-Aziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

Background: Misoprostol is a synthetic analog of prostaglandin-E1 and it is the most widely used drug for the medical management of incomplete abortion. Acute Coronary Syndrome (ACS) rarely occurs in perimenopausal women, in addition, its presentation is atypical, so the disease is not always recognized.

Case Report: We describe a case of 39-year-old woman with no major underlying cardiovascular risk factors, who developed an episode of ACS following the administration of two doses of misoprostol. Read More