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Int J Surg Case Rep 2021 Jun 18;84:106119. Epub 2021 Jun 18.

Crozer-Chester Medical Center, Center for Minimally Invasive and Bariatric Surgery, 1 Medical Center Blvd. POB II, Suite 220, Upland, PA 19013, United States of America. Electronic address:

Introduction And Importance: During gestation, laparoscopic procedures, if needed, are generally considered most ideal within the second trimester. There are less reports of successful laparoscopic procedures in the third trimester of pregnancy due to performance hesitancy with concerns of preterm labor and/or other complications. While it is rare for laparoscopic cholecystectomy to be performed within the third trimester, it should not be delayed if needed, and excellent outcomes can be achieved with proper port placement and procedure. Read More

Int J Gynaecol Obstet 2021 Jun 24. Epub 2021 Jun 24.

Gynecology department, Phuentsholing Hospital, Chukha, Bhutan.

A fistula is defined as an abnormal communication between two epithelized surfaces-a cervico-cutaneous fistula is an unusual communication between the uterine cervix and the skin. Vesicovaginal, recto-vaginal,and uterovaginal fistulae are rare complications associated withobstetric trauma and gynecological surgery [1]. It is unusual and extremely rare for a cervico-cutaneous fistula to occur as a result of cesarean delivery. Read More

Medicine (Baltimore) 2021 Jun;100(25):e26264

The Department of Clinical Laboratory Medicine, Yongchuan Hospital, Chongqing Medical University, Yongchuan, Chongqing, China.

Background: Antiphospholipid antibody syndrome (APS) is a systemic, autoimmune, prothrombotic disease characterized by persistent antiphospholipid antibodies, thrombosis, recurrent abortion, complications during pregnancy, and occasionally thrombocytopenia. At present, there is no consensus on the treatment of this disease. Long-term anticoagulation is recommended in most cases in patients with thrombotic APS. Read More

Wiad Lek 2021 ;74(4):940-947

ISIDA-IVF MEDICAL CENTER LLC, KYIV, UKRAINE.

Objective: The aim: To carry out a statistical analysis of physical and reproductive health characteristics in women after ineffective reattempts of using assisted reproductive technologies and identify significant medical and social factors contributing to the development of chronic endometritis.

Patients And Methods: Materials and methods: We carried out a statistical analysis involving 177 outpatient medical records: group 1 includes 127 women aged under 45 with two or more ineffective attempts of in vitro fertilization; group 2 comprised 50 healthy women without reproductive disorders. The complete physical exam included past history, clinical and gynecologic examination, lab techniques and medical imaging according to outpatient medical records obtained during the follow-up care in Isida-IVF Medical Center LLC. Read More

Wiad Lek 2021 ;74(4):915-922

LELEKA MATERNITY HOSPITAL LLC, KYIV, UKRAINE.

Objective: The aim: To carry out a comparative statistical analysis of obstetric and perinatal complications in singleton and multiple pregnancies once assisted reproductive technologies (ART) are applied according to the records taken from archival materials (maternity and delivery records) and identify the clinical features of multiple pregnancy.

Patients And Methods: Materials and methods: Over the period of 2017-2019, 522 women gave birth in LELEKA Maternity Hospital LLC after using assisted reproductive technologies and 331 women among them were followed-up in the women's health center of LELEKA maternity hospital. Among these women (522) with singleton pregnancy 445 women gave birth, while in multiple pregnancy - 77. Read More

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Obstetrics and Gynaecology Department, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal.

Gestational trophoblastic disease occurs in 1-3:1000 gestations worldwide. Up to one-fifth of complete hydatidiform moles undergo malignant transformation, with 2%-4% manifesting as metastatic disease. Of these, a third present with vaginal metastases, which can cause bleeding and discharge. Read More

J Med Case Rep 2021 Jun 21;15(1):321. Epub 2021 Jun 21.

Department of Obstetrics and Gynecology, The Aga Khan Hospital-Dar es Salaam, PO Box 2289, Dar es Salaam, Tanzania.

Background: Multiple gestation has been on the rise because of advancement in assisted reproductive technology. Triplet pregnancy is associated with fetal loss and preterm birth as its major complications. Spontaneous triplet pregnancy is rare. Read More

Zhonghua Fu Chan Ke Za Zhi 2021 Jun;56(6):418-424

Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To study the risk assessment, method selection and clinical management of pregnancy termination during the first and second trimester of pregnant women with cardiovascular disease. This study focused on pregnant women with cardiovascular diseases who were admitted to Beijing Anzhen Hospital during the first and second trimester of pregnancy from January 2016 to September 2019, to summarize their clinical characteristics, reasons and methods of pregnancy termination, management and outcomes. Among 167 pregnant women, 119 cases (71. Read More

J Orthop Case Rep 2021 Feb;11(2):15-18

Department of Orthopaedics, Apollo Speciality Hospitals, Chennai, Tamil Nadu, India.

Introduction: Arthritis in primary antiphospholipid antibody syndrome (PAPS) is a rare manifestation that is much more common in secondary antiphospholipid antibody syndrome (APS), particularly those associated with systemic lupus erythematosis (SLE), and has been reported to be non-erosive responding to conservative management. In this background, we describe a case of secondary erosive arthritis of knee (SEAK) in a female patient with PAPS.

Case Report: Thirty-seven-year-old working women presented with chronic right knee pain for the past 2 years which was increasing in severity and interfering with her activities of daily living for the past 3 months. Read More

Leg Med (Tokyo) 2021 Jun 7;53:101927. Epub 2021 Jun 7.

Department of Forensic Medicine & Toxicology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry 605006, India; Department of Forensic Medicine & Toxicology, Jawaharlal Institute of Postgraduate Medical Education & Research, Karaikal, India.

The present paper is a case-based review on rare complications of illegal abortion, i.e., necrotizing fasciitis missed early by the treating gynecologists which landed up into a negligence tort against the physicians. Read More

BMC Infect Dis 2021 Jun 12;21(1):564. Epub 2021 Jun 12.

School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia.

Background: Listeria monocytogenes (LM) has come to be a major public health issue of at-risk groups, causing high morbidity and mortality. Despite this data, studies are very limited in developing countries like Ethiopia. Thus, we aimed to isolate and characterize LM in terms of antibiogram and biofilm formation among pregnant women with fever, women with a history of spontaneous abortion, women with a history of fetal loss, and women with preterm delivery at Jimma University Medical Center (JUMC), southwest Ethiopia. Read More

Cochrane Database Syst Rev 2021 Jun 11;6:CD013566. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA.

Background: Medical abortion is usually offered in a clinic or hospital, but could potentially be offered in other settings such as pharmacies. In many countries, pharmacies are a common first point of access for women seeking reproductive health information and services. Offering medical abortion through pharmacies is a potential strategy to improve access to abortion. Read More

Int J Burns Trauma 2021 15;11(2):90-95. Epub 2021 Apr 15.

Department of Pediatrics, Imam Reza Hospital, Kermanshah University of Medical Sciences Kermanshah, Iran.

Objective: Burn injuries in the course of pregnancy can lead to significant complications and mortality for both mother and fetus. Mortality and morbidity depend on the severity of burn. The current article is the third report authored on burn during pregnancy from Kermanshah, Iran. Read More

J Pharm Bioallied Sci 2021 Jan-Mar;13(1):88-92. Epub 2020 Dec 16.

Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.

Introduction: Off-label drug use (OLDU) refers to the prescription of a currently available and marketed medication for a use that has never been approved by the Food and Drug Administration (FDA). Misoprostol is one of the drugs which is used off-label. This drug, authorized for the treatment or prevention of peptic ulcers and other stomach disorders, is commonly used off-label for inducing labor or intrauterine device insertion. Read More

BMJ 2021 06 3;373:n1233. Epub 2021 Jun 3.

Department of Hyperbaric Oxygen, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

Front Mol Biosci 2021 17;8:656844. Epub 2021 May 17.

Microbiology, DIMES, University of Bologna, Bologna, Italy.

During pregnancy, the vaginal ecosystem undergoes marked changes, including a significant enrichment with spp. and profound alterations in metabolic profiles. A deep comprehension of the vaginal environment may shed light on the physiology of pregnancy and may provide novel biomarkers to identify subjects at risk of complications (e. Read More

Int J Womens Health 2021 24;13:489-499. Epub 2021 May 24.

School of Nursing and Midwifery, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Abortion rates following unintended pregnancies are increasing in developing countries, and unsafe abortion is a commonly neglected reproductive health-care problem. In Ethiopia, the number of women receiving treatment for complications from unsafe abortion is increasing. Improving the level of knowledge of reproductive-age women on medication abortion contributes to the prevention of unsafe abortion. Read More

Afr J Reprod Health 2021 Feb;25(1):122-128

Istanbul IVF Center, Istanbul, Turkey.

This study evaluated pregnancy results after fresh and frozen embryo transfer in males with infertility due to non-obstructive azoospermia and oligoasthenoteratozoospermia. In this retrospective study, a total of 801 embryo transfer cycles were followed up, including 423 fresh embryo transfers and 378 frozen embryo transfers in which intracytoplasmic sperm injection (ICSI) was performed because of male infertility. This study included females aged 28-38 years without uterine, endometrial, ovarian and tubal abnormalities and with regular menstrual cycles (n=801), and males aged 28-38 years with non-obstructive azoospermia and oligoasthenoteratozoospermia. Read More

Afr J Reprod Health 2021 Feb;25(1):49-55

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.

Bacterial Vaginosis (BV) has recently emerged as a global health issue especially in pregnant women because of its adverse outcomes. Various studies have shown the impact of BV on both mother and baby as well as overall reproductive health of women. The study intended to assess the prevalence of BV in pregnant women visiting our hospital and estimate the risk of associated complications. Read More

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

A pandemic of acute respiratory infections, due to a new type of coronavirus, can cause Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) and has created the need for a better understanding of the clinical, epidemiological, and pathological features of COVID-19, especially in high-risk groups, such as pregnant women. Viral infections in pregnant women may have a much more severe course, and result in an increase in the rate of complications, including spontaneous abortion, stillbirth, and premature birth-which may cause long-term consequences in the offspring. In this review, we focus on the mother-fetal-placenta interface and its role in the potential transmission of SARS-CoV-2, including expression of viral receptors and proteases, placental pathology, and the presence of the virus in neonatal tissues and fluids. Read More

BMJ Case Rep 2021 May 31;14(5). Epub 2021 May 31.

Urology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Urolithiasis is the most common non-obstetric complication in pregnancy and has the potential to cause grave consequences resulting in pregnancy loss. We present two such cases. First, a 24-year-old woman, 5 weeks pregnant with a history of urolithiasis presented with right flank pain and fever. Read More

Theriogenology 2021 Sep 25;171:155-161. Epub 2021 May 25.

Department of Veterinary Science, University of Kentucky, Lexington, KY, USA. Electronic address:

Placentitis is the leading cause of infectious abortion in the horse and contributes to roughly 19% of all abortions in the United States. A type of placental infection, nocardioform placentitis (NP) is associated with gram-positive branching actinomycetes localized within the ventral body of the feto-maternal interface to create a lymphoplasmacytic mucoid lesion. While the etiology of this disease is poorly described, this placental infection continues to cause episodic abortions in addition to weak and/or growth retarded neonates. Read More

Stud Fam Plann 2021 May 27. Epub 2021 May 27.

Akanni Akinyemi, Centre for Research, Evaluation Resources and Development (CRERD), Ile-Ife, Nigeria.

Little is known about the link between health literacy and women's ability to safely and successfully use misoprostol to self-induce an abortion. While abortion is only allowed to save a woman's life in Nigeria, misoprostol is widely available from drug sellers. We interviewed 394 women in 2018 in Lagos State, Nigeria, who induced abortion using misoprostol obtained from a drug seller to determine their sexual and reproductive health literacy (SRHL) and misoprostol knowledge levels; and how these were associated with ending the pregnancy successfully or seeking care for (perceived) complications. Read More

CMAJ 2021 05;193(21):E753-E760

Division of General Surgery (Gomez, Nantais), St. Michael's Hospital, Unity Health Toronto; ICES Central (Gomez, Simpson, de Mestral, Wilton, Urbach, Austin, Baxter); Department of Obstetrics and Gynecology (Simpson), St. Michael's Hospital, Unity Health Toronto; Department of Surgery (Sue-Chue-Lam, de Mestral, Dossa, Urbach), Faculty of Medicine, University of Toronto, Toronto, Ont.; Melbourne School of Population and Global Health (Baxter), University of Melbourne, Melbourne, Australia.

Background: Reduced use of the emergency department during the COVID-19 pandemic may result in increased disease acuity when patients do seek health care services. We sought to evaluate emergency department visits for common abdominal and gynecologic conditions before and at the beginning of the pandemic to determine whether changes in emergency department attendance had serious consequences for patients.

Methods: We conducted a population-based analysis using administrative data to evaluate the weekly rate of emergency department visits pre-COVID-19 (Jan. Read More

J Matern Fetal Neonatal Med 2021 May 24:1-6. Epub 2021 May 24.

Department of Obstetrics and Gynecology, Strong Memorial Hospital, University of Rochester, Rochester, NY, USA.

Background: Induction abortion in the second trimester may be favored in some instances, such as in women with compounding medical conditions or when skilled providers are not available. Various methods of pre-induction cervical preparation have been used to shorten the length of induction and decrease the risk of complications. The benefits of cervical preparation with laminaria before D&E have been well studied, but the benefits of laminaria before medical induction are less clear. Read More

J Matern Fetal Neonatal Med 2021 May 23:1-4. Epub 2021 May 23.

Department of Obstetrics and Gynecology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

Objective: Fetuin-A is a hepatokine which is previously found related to fertility and pregnancy outcomes. We aimed to investigate if recurrent pregnancy loss (RPL) is associated with increased fetuin-A levels.

Materials And Methods: Serum fetuin-A concentrations were measured and compared in 30 non-pregnant women with a history of unexplained recurrent miscarriage, 29 women who had a history of unexplained recurrent miscarriage and were admitted to our clinic due to miscarriage during the study period and 30 fertile women who have no history of miscarriage or any other pregnancy complications with at least two previous healthy children. Read More

J Med Case Rep 2021 May 21;15(1):298. Epub 2021 May 21.

Department of Obstetrics and Gynecology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Conjoined twins are a rare clinical event occurring in about 1 per 250,000 live births. Though the prognosis of conjoined twins is generally low, there is limited evidence as to the optimal method of pregnancy termination, particularly in cases of advanced gestational age. We report a successful dilation and evacuation (D&E) done for conjoined twins at 22 weeks of gestation. Read More

Life Sci 2021 Aug 18;278:119632. Epub 2021 May 18.

School of Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, United Kingdom. Electronic address:

Diabetes epidemiological quantities are demonstrating one of the most important communities' health worries. The essential diabetic difficulties are including cardiomyopathy, nephropathy, inflammation, and retinopathy. Despite developments in glucose decreasing treatments and drugs, these diabetic complications are still ineffectively reversed or prohibited. Read More

Medicine (Baltimore) 2021 May;100(20):e25968

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.

Introduction: Primary hyperparathyroidism (PHPT) in pregnancy is rare and unrecognized because the maternal physiological adaptations blurs the symptoms. There is no standard treatment strategy for maternal PHPT. Early diagnosis and interventions can prevent catastrophic consequences to the mother and fetus. Read More

BMC Pregnancy Childbirth 2021 May 17;21(1):378. Epub 2021 May 17.

Students' Research Committee, Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Physiological changes during pregnancy put pregnant women at higher risk for COVID-19 complications. The objective of this study was to evaluate clinical and laboratory characteristics and outcomes of 24 COVID-19 pregnant patients and their newborns referred to the Al-Zahra tertiary maternity hospital in Tabriz, Iran.

Methods: Clinical records of 24 COVID-19 confirmed pregnant patients were retrospectively reviewed from10 March 2020 to 15 April 2020. Read More