759 results match your criteria Abnormal Neonatal EEG


Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.

Lancet Neurol 2018 Nov 14. Epub 2018 Nov 14.

Centre for Perinatal Neuroscience, Imperial College London, London, UK. Electronic address:

Background: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance (MR) spectroscopy (MRS) biomarkers as early predictors of the neurodevelopmental abnormalities observed years after neonatal encephalopathy.

Methods: We did a prospective multicentre cohort study across eight neonatal intensive care units in the UK and USA, recruiting term and near-term neonates who received therapeutic hypothermia for neonatal encephalopathy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14744422183032
Publisher Site
http://dx.doi.org/10.1016/S1474-4422(18)30325-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291458PMC
November 2018
5 Reads

[Clinical and laboratory characteristics and genetic diagnosis of Kabuki syndrome].

Zhonghua Er Ke Za Zhi 2018 Nov;56(11):846-849

Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

To investigate the clinical features, laboratory characteristics and genetic diagnosis of Kabuki syndrome (KS). Between September 2014 and September 2016, seven children with clinically diagnosed KS from the neurology department, Beijing Children Hospital, Capital Medical University were included in this study. Three of them were male and 4 were female aged from 19 days to 6 years and 4 months with a median age of 3 years and 1 month. Read More

View Article

Download full-text PDF

Source
November 2018
4 Reads

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling.

J Vis Exp 2018 Oct 11(140). Epub 2018 Oct 11.

Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health;

Sleep is critical for proper development and neural plasticity. Moreover, abnormal sleep patterns are characteristic of many neurodevelopmental disorders. Studying how chronic sleep restriction during development can affect adult behavior may add to our understanding of the emergence of behavioral symptoms of neurodevelopmental disorders. Read More

View Article

Download full-text PDF

Source
https://www.jove.com/video/58150/chronic-sleep-deprivation-i
Publisher Site
http://dx.doi.org/10.3791/58150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235482PMC
October 2018
6 Reads

Clinical and neuropsychological outcomes for children with phenylketonuria in Upper Egypt; a single-center study over 5 years.

Neuropsychiatr Dis Treat 2018 5;14:2551-2561. Epub 2018 Oct 5.

Public Health and Community Medicine Department, Faculty of Medicine, Sohag University, Sohag, Egypt.

Background: Phenylketonuria (PKU) is considered to be a rare inborn error of metabolism but one of the commonest causes of mental retardation if untreated.

Objectives: The present study was done to characterize the clinical patterns of PKU and analyze various neuropsychiatric outcomes in PKU children in Sohag Province, Egypt.

Patients And Methods: A prospective cohort study was conducted on 113 PKU patients, diagnosed during the period from 2012 to 2017, at the Pediatric Neurology Clinic of Sohag University Hospital, Upper Egypt. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/clinical-and-neuropsychological-ou
Publisher Site
http://dx.doi.org/10.2147/NDT.S176198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179721PMC
October 2018
6 Reads

Predictive Value of Midline Spikes on Pediatric EEG for Seizure and Developmental Outcome.

J Clin Neurophysiol 2018 Nov;35(6):490-495

Department of Pediatrics, Division of Neurology, BC Children's Hospital, Vancouver, Canada.

Purpose: Midline spikes are epileptiform discharges localized to the midsagittal regions of the brain. Isolated midline spikes are rare, but more common in children. Our objective was to determine whether midline spikes are predictive of seizure characteristics and neurodevelopment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNP.0000000000000516DOI Listing
November 2018
10 Reads
1.600 Impact Factor

Evaluation of the efficacy of amplitude-integrated electroencephalography in the screening of newborns with metabolic disorder admitted to the NICU.

BMC Med Imaging 2018 09 20;18(1):33. Epub 2018 Sep 20.

Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Neonate patients with metabolic disorder show encephalopathy and seizures that may lead to morbidity and mortality. Thus rapid detection and treatment of these patients is necessary. Although Amplitude-integrated electroencephalography (aEEG) has been used for more than a decade in the evaluation of infants with encephalopathy but has not been used in the assessment of neonates suffering from metabolic disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12880-018-0274-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148992PMC
September 2018

Early Retinal Findings Following Cooling in Neonatal Encephalopathy.

Neuropediatrics 2018 Sep 20. Epub 2018 Sep 20.

Department of Neonatology, UCL EGA Institute for Women's Health (IfWH), University College London, London, United Kingdom.

Background And Aim:  Perinatal HI (hypoxia-ischemia)-related visual defects including blindness are known to be associated with ischemic lesions in intracerebral visual pathways and ischemic retinal damage (IRD). Intraocular hemorrhages (IOH) such as retinal hemorrhage (RH), which may result from perinatal HI, can cause IRD by various mechanisms. We aimed to evaluate the early retinal findings in neonates with moderate-to-severe neonatal encephalopathy (NE) who underwent TH and its relationship between coagulation status, amplitude-integrated electroencephalography (aEEG) patterns, and magnetic resonance imaging-magnetic resonance spectroscopy (MRI-MRS) findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1669425DOI Listing
September 2018
1 Read

High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy.

Seizure 2018 Oct 11;61:221-226. Epub 2018 Sep 11.

Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States; Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

Purpose: Electroencephalographic seizures (ES) are common among neonates with hypoxic-ischemic encephalopathy (HIE), and they represent a treatable complication that might improve neurodevelopmental outcomes. We aimed to establish whether higher ES exposure was predictive of unfavorable outcomes while adjusting for other important clinical and electroencephalographic parameters.

Methods: We performed a single-center, retrospective study of consecutive neonates with HIE managed with therapeutic hypothermia from June 2010 through December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168337PMC
October 2018
1 Read

Clinical characteristics and aetiology of early childhood epilepsy: a single centre experience in Saudi Arabia.

Sudan J Paediatr 2018 ;18(1):57-62

Paediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Seizures in children and neonatal period have variety of causes; however, most of childhood seizures are idiopathic. The aim of this study was to review the causes of epilepsy in children presenting in the first 2 years of life using the International League Against Epilepsy classification released in 2010. This was a retrospective chart review study that was conducted at a tertiary center in Saudi Arabia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24911/SJP.2018.1.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113787PMC
January 2018
6 Reads

Amplitude-Integrated Electroencephalography for Early Recognition of Brain Injury in Neonates with Critical Congenital Heart Disease.

J Pediatr 2018 Nov 22;202:199-205.e1. Epub 2018 Aug 22.

Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands. Electronic address:

Objective: To study perioperative amplitude-integrated electroencephalography (aEEG) as an early marker for new brain injury in neonates requiring cardiac surgery for critical congenital heart disease (CHD).

Study Design: This retrospective observational cohort study investigated 76 neonates with critical CHD who underwent neonatal surgery. Perioperative aEEG recordings were evaluated for background pattern (BGP), sleep-wake cycling (SWC), and ictal discharges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.06.048DOI Listing
November 2018
6 Reads

Prediction of Response to Treatment in Children with Epilepsy.

Iran J Child Neurol 2018 ;12(3):94-100

Child Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs.

Material And Methods: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The inclusion criteria were children 2 months to 12 yr of age with epilepsy and patients who experienced fever and seizure attacks at least once were excluded from the study. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045937PMC
January 2018
7 Reads

Early Amplitude-Integrated Electroencephalogram as a Predictor of Brain Injury in Newborns With Very Low Birth Weight: A Cohort Study.

J Child Neurol 2018 Sep 13;33(10):659-663. Epub 2018 Jun 13.

1 Postgraduate Program in Child and Adolescent Health, UFRGS, Porto Alegre, Brazil.

Purpose: To evaluate the relationship between abnormal early amplitude integrated electroencephalography (EEG) and severe lesions in imaging tests performed during the neonatal period in very low birth weight infants.

Methods: An amplitude-integrated EEG was performed in 70 patients with a mean birth weight of 1226 g during the first 48 hours of life. Severe lesions on magnetic resonance imaging (MRI) or ultrasonography (US) during the neonatal period were considered as adverse conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0883073818778468DOI Listing
September 2018
9 Reads

Long-term outcome in children with neonatal seizures: A tertiary center experience in cohort of 168 patients.

Epilepsy Behav 2018 Jul 15;84:107-113. Epub 2018 May 15.

Institute for Mother and Child Healthcare of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Purpose: The purpose of this study was to evaluate long-term outcome and assess predictors of prognosis in children with neonatal seizures (NS).

Method: This retrospective study includes children with NS treated at our Institute from January the 1st 2005 until December the 31st 2015. The data were collected from medical charts and the electroencephalogram (EEG) database at the Institute. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2018.05.002DOI Listing

Yield of EEG monitoring in children with developmental disabilities is high.

Epilepsy Behav 2018 Jul 12;84:105-106. Epub 2018 May 12.

Neurosciences Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. Electronic address:

Purpose: The purpose of this study was to investigate the yield of a 2-hour electroencephalography (EEG) monitoring (awake and sleep) in children with developmental disabilities and without any clinically apparent seizures.

Methods: In this retrospective study, I investigated all children below 9 years of age who had developmental disabilities and were referred to Shiraz Comprehensive Epilepsy center for electroencephalographic investigation from June 2017 until January 2018. Exclusion criteria included any past history of neonatal seizures, febrile or afebrile seizures, and parental suspicion for seizures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2018.04.023DOI Listing

Visual evoked potentials are similar in polysomnographically defined quiet and active sleep in healthy newborns.

Int J Dev Neurosci 2018 Apr 23;68:26-34. Epub 2018 Apr 23.

Research Unit in Neurodevelopment, Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, 76230, Mexico. Electronic address:

Morphology and late components of evoked potentials change depending on wake-sleep stages in adults. Visual Evoked potentials (VEPs) have been frequently studied in newborns to identify abnormal development of visual pathways; however, large variability has been reported and there is uncertainty as to the effect of sleep stages on VEPs in neonates.

Objective: To describe the characteristics of VEPs in one month old, healthy full-term newborns during active sleep (AS) and quiet sleep (QS), defined by simultaneous polysomnography (PSG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijdevneu.2018.04.007DOI Listing
April 2018
2 Reads

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

Clin Chim Acta 2018 Aug 9;483:14-19. Epub 2018 Apr 9.

Division of Neonatology, Children's Hospital of Fudan University, Shanghai, China; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China; Key Laboratory of Neonatal Diseases, Ministry of Health, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

Background: We investigated the association between SCN1A and SCN2A mutations and clinical phenotype and electroencephalography (EEG) features.

Methods: In this study, 48 patients suffered from epilepsy or severe seizures with SCN1A and SCN2A mutations were recruited. Medical data and molecular diagnosis were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2018.03.027DOI Listing
August 2018
4 Reads
2.820 Impact Factor

Clinical and electrophysiological findings in patients with phenylketonuria and epilepsy: Reflex features.

Epilepsy Behav 2018 05 24;82:46-51. Epub 2018 Mar 24.

Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: Phenylketonuria (PKU) is the most common form of amino acid metabolism disorders with autosomal recessive inheritance. The brain damage can be prevented by early diagnosis and a phenylalanine-restricted diet. Untreated or late-treated patients may show mental retardation and other cognitive dysfunctions, as well as motor disability and/or epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2018.02.024DOI Listing
May 2018
6 Reads

Electroencephalography abnormalities in generalized epilepsy and their predictors: A multicenter experience.

Ann Afr Med 2018 Apr-Jun;17(2):64-69

Department of Psychiatry, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria.

Background: In spite of the overwhelming significance of knowledge of basic elements of electroencephalography (EEG) in its application to the diagnostic workup and the management of patients with suspected or already established generalized epilepsy (GE), there is a dearth of data on the pattern and utility of clinical variables that can independently determine EEG abnormalities in GE.

Objective: The study was designed to evaluate the frequency and pattern of EEG abnormality as well as assess the utility of clinical variables in predicting the likelihood of an abnormal EEG in GE.

Methods: It was a cross-sectional study involving the analysis of EEGs of consecutive patients with clinical diagnosis of idiopathic GE from three centers over a 7-year period. Read More

View Article

Download full-text PDF

Source
http://www.annalsafrmed.org/text.asp?2018/17/2/64/227173
Publisher Site
http://dx.doi.org/10.4103/aam.aam_2_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875121PMC
July 2018
2 Reads

Prematurity, ventricular septal defect and dysmorphisms are independent predictors of pathogenic copy number variants: a retrospective study on array-CGH results and phenotypical features of 293 children with neurodevelopmental disorders and/or multiple congenital anomalies.

Ital J Pediatr 2018 Mar 9;44(1):34. Epub 2018 Mar 9.

Clinical Genetics Unit, Maternal and Child Health Department, AUSL-IRCCS of Reggio Emilia, Reggio Emilia, Italy.

Background: Since 2010, array-CGH (aCGH) has been the first-tier test in the diagnostic approach of children with neurodevelopmental disorders (NDD) or multiple congenital anomalies (MCA) of unknown origin. Its broad application led to the detection of numerous variants of uncertain clinical significance (VOUS). How to appropriately interpret aCGH results represents a challenge for the clinician. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13052-018-0467-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845186PMC
March 2018
4 Reads

Outcomes after acute symptomatic seizures in neonates.

Semin Fetal Neonatal Med 2018 06 6;23(3):218-222. Epub 2018 Feb 6.

Department of Pediatrics, Department of Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.

Acute symptomatic seizures are a common sign of neurological dysfunction and brain injury in neonates and occur in approximately one to three per 1000 live births. Seizures in neonates are usually a sign of underlying brain injury and, as such, are commonly associated with adverse outcomes. Neurological morbidities in survivors often co-occur; epilepsy, cerebral palsy, and intellectual disability often occur together in the most severely affected children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.siny.2018.02.001DOI Listing
June 2018
1 Read

The Predictive Value of Amplitude-Integrated Electroencephalography in Preterm Infants for IQ and Other Neuropsychological Outcomes at Early School Age.

Neonatology 2018 13;113(4):287-295. Epub 2018 Feb 13.

Background: Amplitude-integrated electroencephalography (aEEG) is used increasingly in neonatal intensive care and seems helpful in predicting outcomes at the age of 2 years.

Objectives: To determine whether early aEEG patterns in preterm infants are equally useful in predicting outcomes at early school age.

Methods: We recorded aEEG in 41 preterms (gestational age 26. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000486704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039092PMC
February 2018
1 Read

Amplitude-integrated electroencephalography during the first 72 h after birth in neonates diagnosed prenatally with congenital heart disease.

Pediatr Res 2018 Apr 10;83(4):798-803. Epub 2018 Jan 10.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatrics, Divison of Neonatology, Groningen, The Netherlands.

BackgroundLittle is known on amplitude-integrated electroencephalography (aEEG) during the first few days after birth in neonates with congenital heart disease (CHD). Our aim was, therefore, to assess electrocortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG.MethodsNeonates with CHD who were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/pr.2017.311DOI Listing
April 2018
11 Reads

Clinical Manifestations and Amplitude-integrated Encephalogram in Neonates with Early-onset Epileptic Encephalopathy.

Chin Med J (Engl) 2017 Dec;130(23):2808-2815

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

Background: The patients with early-onset epileptic encephalopathy (EOEE) suffer from neurodevelopmental delay. The aim of this study was to analyze the clinical manifestations and amplitude-integrated encephalogram (aEEG) characteristics of infants with EOEE with onset within the neonatal period, to make early diagnosis to improve the prognosis.

Methods: One-hundred and twenty-eight patients with neonatal seizure were enrolled and followed up till 1 year old. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0366-6999.219152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717859PMC
December 2017
3 Reads

Reorganization of the somatosensory cortex in hemiplegic cerebral palsy associated with impaired sensory tracts.

Neuroimage Clin 2018 19;17:198-212. Epub 2017 Oct 19.

Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Functional neuroimaging studies argue that sensory deficits in hemiplegic cerebral palsy (HCP) are related to deviant somatosensory processing in the ipsilesional primary somatosensory cortex (S1). A separate body of structural neuroimaging literature argues that these deficits are due to structural damage of the ascending sensory tracts (AST). The relationship between the functional and structural integrity of the somatosensory system and the sensory performance is largely unknown in HCP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2017.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683344PMC
June 2018
4 Reads

Anatomical and physiological basis of continuous spike-wave of sleep syndrome after early thalamic lesions.

Epilepsy Behav 2018 01 11;78:243-255. Epub 2017 Nov 11.

Hospital Garcia de Orta, Pediatric Neurology Department, Almada, Portugal.

Objective: Early neonatal thalamic lesions account for about 14% of continuous spike-wave of sleep (CSWS) syndrome, representing the most common etiology in this epileptic encephalopathy in children, and promise useful insights into the pathophysiology of the disease.

Methods: We describe nine patients with unilateral neonatal thalamic lesions which progressed to CSWS. Longitudinal whole-night and high-density electroencephalograms (EEGs) were performed, as well as detailed imaging and clinical evaluation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15255050173021
Publisher Site
http://dx.doi.org/10.1016/j.yebeh.2017.08.027DOI Listing
January 2018
12 Reads

Relevance of urinary S100B protein levels as a short-term prognostic biomarker in asphyxiated infants treated with hypothermia.

Medicine (Baltimore) 2017 Nov;96(44):e8453

Neonatal Unit, Department of Pediatrics, Santiago de Compostela University Hospital, IDIS (Health Research Institute of Santiago de Compostela), CIBERER, Travesia Choupana, Santiago de Compostela, Spain.

The initial diagnosis of neonatal hypoxic-ischemic encephalopathy is based on nervous system clinical manifestations. The use of biomarkers to monitor brain injury and evaluate neuroprotective effects allows early intervention and treatment. This study was designed to determine the short-term prognostic significance of urinary S100B calcium-binding protein (S100B) in asphyxiated newborns treated with hypothermia. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201711030-0004
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000008453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682810PMC
November 2017
19 Reads

Clinical significance of dynamic measurements of seric TNF-α, HMGBl, and NSE levels and aEEG monitoring in neonatal asphyxia.

Eur Rev Med Pharmacol Sci 2017 Oct;21(19):4333-4339

Department of Pediatrics, Yidu Central Hospital, Weifang, Shandong Province, P.R. China.

Objective: This study investigates the clinical value of monitoring blood levels of tumor necrosis factor-α (TNF-α), high mobility group protein Bl (HMGBl), and neuron-specific enolase (NSE), and examining an amplitude-integrated electroencephalogram (aEEG) for the diagnosis and short-term prognosis of brain damage caused by neonatal asphyxia.

Patients And Methods: Sixty full-term neonates born in Yidu Central Hospital from January to December 2015 were enrolled in the study. The neonates were classified into one of 3 groups: 23 neonates in the mild asphyxia group, 7 in a severe asphyxia group and 30 in a control group admitted to the NICU but without asphyxia. Read More

View Article

Download full-text PDF

Source
October 2017
5 Reads

Predictors of Poor Outcome in Neonates with Pyogenic Meningitis in a Level-Three Neonatal Intensive Care Unit of Developing Country.

J Trop Pediatr 2018 Aug;64(4):297-303

Department of Paediatrics, King George's Medical University (KGMU), Lucknow, UP 226003, India.

Background: The mortality of neonatal pyogenic meningitis is reduced to 10-15%, but morbidity is unchanged.

Methods: Primary objective is to determine the outcome, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/tropej/fmx066DOI Listing
August 2018
7 Reads
0.860 Impact Factor

Functional ultrasound imaging of brain activity in human newborns.

Sci Transl Med 2017 Oct;9(411)

Assistance Publique-Hôpitaux de Paris, Neonatal Intensive Care Unit, Robert Debré University Hospital, 75019 Paris, France.

Functional neuroimaging modalities are crucial for understanding brain function, but their clinical use is challenging. Recently, the use of ultrasonic plane waves transmitted at ultrafast frame rates was shown to allow for the spatiotemporal identification of brain activation through neurovascular coupling in rodents. Using a customized flexible and noninvasive headmount, we demonstrate in human neonates that real-time functional ultrasound imaging (fUSI) is feasible by combining simultaneous continuous video-electroencephalography (EEG) recording and ultrafast Doppler (UfD) imaging of the brain microvasculature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aah6756DOI Listing
October 2017
20 Reads

Convulsive status epilepticus in a quaternary hospital paediatric intensive care unit (PICU) in South Africa: An 8 year review.

Seizure 2017 Oct 2;51:55-60. Epub 2017 Aug 2.

Department of Paediatric Neurology, University of KwaZulu-Natal, Durban, South Africa.

Purpose: Convulsive status epilepticus (CSE) is associated with a high morbidity and mortality. This study aimed to describe the clinical profile, aetiology, neuroimaging and EEG findings as well as outcome of children with CSE in Sub-Saharan Africa.

Methods: This was a retrospective analysis of electronic records of children with CSE admitted to the Paediatric Intensive Care Unit (PICU) over an 8-year period from January 2007 to December 2014. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311173000
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2017.07.016DOI Listing
October 2017
15 Reads

The role of melatonin to attain electroencephalograms in children in a sub-Saharan African setting.

Seizure 2017 Oct 12;51:87-94. Epub 2017 Aug 12.

Departments of Paediatric Neurology, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa; Departments of Neurophysiology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa. Electronic address:

Purpose: Limited access to electroencephalograms (EEGs) in sub-Saharan Africa results in a high patient load attending the few neurophysiology units. The state of sleep in children improves yield and reduces artefact of EEGs. Melatonin induces "natural sleep" without the risk of airway compromise. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2017.08.002DOI Listing
October 2017
19 Reads

Abnormal Interhemispheric Synchrony in Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Pilot Study.

Neonatology 2017 11;112(4):359-364. Epub 2017 Aug 11.

Department of Neonatology, Necker-Enfants Malades Hospital, Paris, France.

Background: Abnormal interhemispheric synchrony has been described in many clinical compromises in brain function, but its prognostic value in neonatal hypoxic-ischemic encephalopathy (HIE) is unknown.

Objectives: The study aimed at describing the frequency of abnormal interhemispheric synchrony in infants with HIE and to explore its prognostic value. The main outcome was survival without major disabilities. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/478964
Publisher Site
http://dx.doi.org/10.1159/000478964DOI Listing
July 2018
20 Reads

Long-term applicability of the new ILAE definition of epilepsy. Results from the PRO-LONG study.

Epilepsia 2017 09 8;58(9):1518-1523. Epub 2017 Aug 8.

IRCCS Mario Negri Institute for Pharmacological Research, Milano, Italy.

Objective: The new epilepsy definition adopted by the International League Against Epilepsy (ILAE) includes patients with one unprovoked seizure with a probability of further seizures, similar to the general recurrence risk after two unprovoked seizures, occurring in a 10-year period. Long-term follow-up of patients diagnosed after a single seizure is needed to assess the applicability of the new epilepsy definition in clinical practice.

Methods: Patients with newly diagnosed epilepsy were recruited retrospectively with a minimum follow-up of 10 years. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/epi.13854
Publisher Site
http://dx.doi.org/10.1111/epi.13854DOI Listing
September 2017
26 Reads

KCNQ2 encephalopathy: A case due to a de novo deletion.

Brain Dev 2018 Jan 17;40(1):65-68. Epub 2017 Jul 17.

Department of Pediatrics, Child Neurology Unit, Santa Maria Nuova Hospital, viale Risorgimento 80, 42123 Reggio Emilia, Italy. Electronic address:

KCNQ2 encephalopathy is characterized by severely abnormal EEG, neonatal-onset epilepsy and developmental delay. It is caused by mutations (typically missense) in the KCNQ2 gene, encoding the voltage gated potassium channel Kv7.2 and leading to a negative-dominant effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2017.06.008DOI Listing
January 2018
10 Reads

Review of sleep-EEG in preterm and term neonates.

Early Hum Dev 2017 10 12;113:87-103. Epub 2017 Jul 12.

Department of Development and Regeneration, University Hospitals Leuven, Neonatal Intensive Care Unit, KU Leuven (University of Leuven), Leuven, Belgium. Electronic address:

Neonatal sleep is a crucial state that involves endogenous driven brain activity, important for neuronal survival and guidance of brain networks. Sequential EEG-sleep analysis in preterm infants provides insights into functional brain integrity and can document deviations of the biologically pre-programmed process of sleep ontogenesis during the neonatal period. Visual assessment of neonatal sleep-EEG, with integration of both cerebral and non-cerebral measures to better define neonatal state, is still considered the gold standard. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.earlhumdev.2017.07.003DOI Listing
October 2017
21 Reads

Inflammatory and vascular placental lesions are associated with neonatal amplitude integrated EEG recording in early premature neonates.

PLoS One 2017 23;12(6):e0179481. Epub 2017 Jun 23.

Department of Neonatology, Soroka University Medical Center, Faculty of Health Sciences, School of Medicine, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Introduction: Placental histologic examination can assist in revealing the mechanism leading to preterm birth. Accumulating evidence suggests an association between intrauterine pathological processes, morbidity and mortality of premature infants, and their long term outcome. Neonatal brain activity is increasingly monitored in neonatal intensive care units by amplitude integrated EEG (aEEG) and indices of background activity and sleep cycling patterns were correlated with long term outcome. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482430PMC
September 2017
32 Reads

Brain Injury and Neurodevelopmental Outcome in Congenital Heart Disease: A Systematic Review.

Pediatrics 2017 Jul 13;140(1). Epub 2017 Jun 13.

Division of Neonatology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, Netherlands; and.

Context: Brain injury during prenatal and preoperative postnatal life might play a major role in neurodevelopmental impairment in infants with congenital heart disease (CHD) who require corrective or palliative surgery during infancy. A systematic review of cerebral findings during this period in relation to neurodevelopmental outcome (NDO), however, is lacking.

Objective: To assess the association between prenatal and postnatal preoperative cerebral findings and NDO in infants with CHD who require corrective or palliative surgery during infancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2016-4055DOI Listing
July 2017
9 Reads

Evoked potentials recorded during routine EEG predict outcome after perinatal asphyxia.

Clin Neurophysiol 2017 07 11;128(7):1337-1343. Epub 2017 May 11.

Department of Clinical Neurophysiology, Children's Hospital, HUS Medical, Imaging Center, University of Helsinki and Helsinki University Hospital (HUH), Helsinki, Finland.

Objective: To evaluate the added value of somatosensory (SEPs) and visual evoked potentials (VEPs) recorded simultaneously with routine EEG in early outcome prediction of newborns with hypoxic-ischemic encephalopathy under modern intensive care.

Methods: We simultaneously recorded multichannel EEG, median nerve SEPs, and flash VEPs during the first few postnatal days in 50 term newborns with hypoxic-ischemic encephalopathy. EEG background was scored into five grades and the worst two grades were considered to indicate poor cerebral recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2017.04.025DOI Listing
July 2017
8 Reads

A patient with Muenke syndrome manifesting migrating neonatal seizures.

Brain Dev 2017 Nov 24;39(10):873-876. Epub 2017 May 24.

Department of Pediatric Neurology, Miyagi Children's Hospital, Miyagi, Japan.

We report a patient with Muenke syndrome who had repetitive apneic spell followed by focal status epilepticus in the early infancy. Ictal EEG showed focal spikes bursts originated from the left hemisphere and sifted to the right hemisphere, during which he had migrating tonic seizures from right side of the body to the left side of the body. Brain MRI showed abnormal development of bilateral hippocampus, which was characterized as abnormal folding of hippocampal gyri. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2017.05.007DOI Listing
November 2017
7 Reads

Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age.

J Pediatr 2017 08 23;187:34-42. Epub 2017 May 23.

Neonatal Neuroscience, School of Medical Sciences, University of Bristol, Bristol, United Kingdom; Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Electronic address:

Objectives: To examine whether using an amplitude-integrated electroencephalography (aEEG) severity pattern as an entry criterion for therapeutic hypothermia better selects infants with hypoxic-ischemic encephalopathy and to assess the time-to-normal trace for aEEG and magnetic resonance imaging (MRI) lesion load as 24-month outcome predictors.

Study Design: Forty-seven infants meeting Norwegian therapeutic hypothermia guidelines were enrolled prospectively. Eight-channel EEG/aEEG was recorded from 6 hours until after rewarming, and read after discharge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2017.04.041DOI Listing
August 2017
44 Reads

Heterogeneity of FHF1 related phenotype: Novel case with early onset severe attacks of apnea, partial mitochondrial respiratory chain complex II deficiency, neonatal onset seizures without neurodegeneration.

Eur J Paediatr Neurol 2017 Sep 29;21(5):783-786. Epub 2017 Apr 29.

APHM, Department of Pediatric Neurology, Hopital de la Timone, Marseille, France; AIx Marseille univ, INSERM, GMGF, UMR_S 910, Faculté de médecine, Marseille, France. Electronic address:

Introduction/objectives: We report the case of a child prospectively followed in our institution for a severe, neonatal onset epilepsy presenting with severe attacks of apnea that were not initially recognized as seizure since they were not associated with any abnormal movement and since interictal EEG was normal. Recording of attacks using prolonged video-EEG recording allowed to confirm the diagnosis of epileptic seizures.

Results: Using whole exome sequencing we found a de novo heterozygous, missense mutation of FHF1 (p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpn.2017.04.001DOI Listing
September 2017
31 Reads

The ability of early serial developmental assessment to predict outcome at 5years following neonatal hypoxic-ischaemic encephalopathy.

Early Hum Dev 2017 07 21;110:1-8. Epub 2017 Apr 21.

Department of Paediatrics and Child Health, University College Cork, Clinical Investigations Unit, Cork University Hospital, Wilton, Cork, Ireland; Irish Centre for Fetal and Neonatal Translational Research (INFANT Centre), Department of Paediatrics and Child Health, Cork University Maternity Hospital, Wilton, Cork, Ireland; Neonatal Brain Research Group, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland. Electronic address:

Background: Neurodevelopmental difficulties in children following hypoxic-ischaemic encephalopathy (HIE) may not emerge until school age.

Aims: To evaluate the value and stability of early serial developmental assessments in predicting long-term outcome.

Study Design: Prospective study of infants with neonatal HIE and early continuous EEG at birth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.earlhumdev.2017.04.006DOI Listing
July 2017
3 Reads

Novel Wavelet Real Time Analysis of Neurovascular Coupling in Neonatal Encephalopathy.

Sci Rep 2017 04 10;7:45958. Epub 2017 Apr 10.

Department of internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Birth asphyxia constitutes a major global public health burden for millions of infants, despite hypothermia therapy. There is a critical need for real time surrogate markers of therapeutic success, to aid in patient selection and/or modification of interventions in neonatal encephalopathy (NE). This is a proof of concept study aiming to quantify neurovascular coupling (NVC) using wavelet analysis of the dynamic coherence between amplitude-integrated electroencephalography (aEEG) and near-infrared spectroscopy in NE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep45958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385531PMC
April 2017
6 Reads

Characterizing regression in Phelan McDermid Syndrome (22q13 deletion syndrome).

J Psychiatr Res 2017 08 16;91:139-144. Epub 2017 Mar 16.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Purpose: To describe the frequency and characteristics of developmental regression in a sample of 50 patients with Phelan McDermid Syndrome (PMS) and investigate the possibility of association between regression, epilepsy, and electroencephalogram (EEG) abnormalities and deletion size.

Methods: The Autism Diagnostic Interview-Revised (ADI-R) was used to evaluate regression in patients with a confirmed diagnosis of PMS. Information on seizure history and EEGs was obtained from medical record review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpsychires.2017.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469716PMC
August 2017
7 Reads

Predictive value of amplitude-integrated EEG (aEEG) after rescue hypothermic neuroprotection for hypoxic ischemic encephalopathy: a meta-analysis.

J Perinatol 2017 Jun 2;37(6):684-689. Epub 2017 Mar 2.

Centre for Perinatal Neuroscience, Department of Paediatrics, Imperial College London, London, UK.

Objective: Amplitude-integrated electroencephalography (aEEG) is a useful bedside tool in predicting the neurodevelopmental outcome after neonatal encephalopathy; however, the prognostic accuracy may be altered by rescue hypothermic neuroprotection. The objective of this study is to examine the prognostic accuracy of aEEG for predicting long-term neurodevelopmental outcomes in term newborn infants undergoing therapeutic hypothermia for neonatal encephalopathy.

Study Design: We examined all studies (Medline, Cumulative Index to Nursing and Allied Health Literature and the Cochrane Library; 2000 to 2014) comparing aEEG (6, 24, 48 or 72 h) in term encephalopathic babies undergoing therapeutic hypothermia, with neurodevelopmental outcome at 1 year or more. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jp.2017.14DOI Listing
June 2017
7 Reads

A Comparison of the Thompson Encephalopathy Score and Amplitude-Integrated Electroencephalography in Infants with Perinatal Asphyxia and Therapeutic Hypothermia.

Neonatology 2017 17;112(1):24-29. Epub 2017 Feb 17.

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: In previous studies clinical signs or amplitude-integrated electroencephalography (aEEG)-based signs of encephalopathy were used to select infants with perinatal asphyxia for treatment with hypothermia.

Aim: The objective of this study was to compare Thompson encephalopathy scores and aEEG, and relate both to outcome.

Subjects And Methods: Thompson scores, aEEG, and outcome were compared in 122 infants with perinatal asphyxia and therapeutic hypothermia. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/455819
Publisher Site
http://dx.doi.org/10.1159/000455819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569711PMC
April 2018
12 Reads

Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.

J Child Neurol 2017 03 20;32(4):360-365. Epub 2016 Dec 20.

6 Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.

This study aimed to characterize the circumstances of death in encephalopathic neonates treated with therapeutic hypothermia. Patients who died after or during treatment with therapeutic hypothermia between 2007-2014 were identified. Patient circumstance of death was characterized using an established paradigm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0883073816681904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359080PMC
March 2017
12 Reads

Interrater agreement in the interpretation of neonatal electroencephalography in hypoxic-ischemic encephalopathy.

Epilepsia 2017 03 6;58(3):429-435. Epub 2017 Feb 6.

Division of Neurophysiology, Epilepsy and Critical Care, Children's National Health System, Washington, District of Columbia, U.S.A.

Objective: Research using neonatal electroencephalography (EEG) has been limited by a lack of a standardized classification system and interpretation terminology. In 2013, the American Clinical Neurophysiology Society (ACNS) published a guideline for standardized terminology and categorization in the description of continuous EEG in neonates. We sought to assess interrater agreement for this neonatal EEG categorization system as applied by a group of pediatric neurophysiologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.13661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339031PMC
March 2017
29 Reads

Prognostic Accuracy of Electroencephalograms in Preterm Infants: A Systematic Review.

Pediatrics 2017 Feb;139(2)

The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark.

Context: Brain injury is common in preterm infants, and predictors of neurodevelopmental outcome are relevant.

Objective: To assess the prognostic test accuracy of the background activity of the EEG recorded as amplitude-integrated EEG (aEEG) or conventional EEG early in life in preterm infants for predicting neurodevelopmental outcome.

Data Sources: The Cochrane Library, PubMed, Embase, and the Cumulative Index to Nursing and Allied Health Literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2016-1951DOI Listing
February 2017
33 Reads