803 results match your criteria Abnormal Neonatal EEG


Identification of Neuronal Structures and Pathways Corresponding to Clinical Functioning in Galactosemia.

J Inherit Metab Dis 2020 Jun 27. Epub 2020 Jun 27.

Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.

Background: Classic galactosemia (OMIM# 230400) is an autosomal recessive disorder due to galactose-1-phosphate uridyltransferase deficiency. Newborn screening and prompt treatment with a galactose-free diet prevent the severe consequences of galactosemia, but clinical outcomes remain suboptimal.

Methods: Five men and 5 women with classic galactosemia (mean age = 27. Read More

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http://dx.doi.org/10.1002/jimd.12279DOI Listing

Cerebrospinal fluid levels of neuron-specific enolase predict the severity of brain damage in newborns with neonatal hypoxic-ischemic encephalopathy treated with hypothermia.

PLoS One 2020 1;15(6):e0234082. Epub 2020 Jun 1.

University of Barcelona, Barcelona, Spain.

Objectives: To investigate whether cerebrospinal fluid levels of neuron-specific enolase (CSF-NSE) during the first 72 hours correlate with other tools used to assess ongoing brain damage, including clinical grading of hypoxic-ischemic encephalopathy (HIE), abnormal patterns in amplitude integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI), as well as with the neurodevelopmental outcomes at two years of age.

Material And Methods: Prospective observational study performed in two hospitals between 2009 and 2011. Forty-three infants diagnosed with HIE within 6 hours of life were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234082PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263594PMC

Applying a data-driven approach to quantify EEG maturational deviations in preterms with normal and abnormal neurodevelopmental outcomes.

Sci Rep 2020 Apr 29;10(1):7288. Epub 2020 Apr 29.

Institute of Biomedical Engineering (IBME), Department of Engineering Science, University of Oxford, Oxford, United Kingdom.

Premature babies are subjected to environmental stresses that can affect brain maturation and cause abnormal neurodevelopmental outcome later in life. Better understanding this link is crucial to developing a clinical tool for early outcome estimation. We defined maturational trajectories between the Electroencephalography (EEG)-derived 'brain-age' and postmenstrual age (the age since the last menstrual cycle of the mother) from longitudinal recordings during the baby's stay in the Neonatal Intensive Care Unit. Read More

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http://dx.doi.org/10.1038/s41598-020-64211-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190650PMC

Early Electroencephalogram Background Could Guide Tailored Duration of Monitoring for Neonatal Encephalopathy Treated with Therapeutic Hypothermia.

J Pediatr 2020 Jun 25;221:81-87.e1. Epub 2020 Mar 25.

Division of Pediatric Neurology, Ann Arbor, MI; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI.

Objective: To evaluate whether features of the early electroencephalographic (EEG) background could guide the optimal duration of continuous video EEG monitoring for seizure detection in newborn infants treated with therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE).

Study Design: Retrospective cohort study of 114 consecutive infants treated with therapeutic hypothermia for moderate to severe HIE at a level IV neonatal intensive care unit (NICU) between 2012 and 2018. All infants were monitored with continuous video EEG through cooling and rewarming. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.01.066DOI Listing

Simultaneous Near-Infrared Spectroscopy (NIRS) and Amplitude-Integrated Electroencephalography (aEEG): Dual Use of Brain Monitoring Techniques Improves Our Understanding of Physiology.

Front Pediatr 2019 21;7:560. Epub 2020 Jan 21.

Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Packard Children's Hospital Stanford, Palo Alto, CA, United States.

Continuous brain monitoring tools are increasingly being used in the neonatal intensive care unit (NICU) to assess brain function and cerebral oxygenation in neonates at high risk for brain injury. Near infrared spectroscopy (NIRS) is useful in critically ill neonates as a trend monitor to evaluate the balance between tissue oxygen delivery and consumption, providing cerebral and somatic oximetry values, and allowing earlier identification of abnormalities in hemodynamics and cerebral perfusion. Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of cerebral function at the bedside. Read More

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http://dx.doi.org/10.3389/fped.2019.00560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985148PMC
January 2020

Prognostic value of amplitude-integrated EEG in neonates with high risk of neurological sequelae.

Ann Clin Transl Neurol 2020 02 7;7(2):210-218. Epub 2020 Feb 7.

Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou, 450052, China.

Objective: To determine the efficacy and the prognostic value of amplitude-integrated electroencephalography (aEEG) in term and near-term neonates with high risk of neurological sequelae.

Methods: Infants of ≥35 weeks of gestation diagnosed with neonatal encephalopathy or with high risk of brain injury were included. All eligible infants underwent aEEG within 6 h after clinical assessment. Read More

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http://dx.doi.org/10.1002/acn3.50989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034499PMC
February 2020

Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.

J Neurosci 2020 Mar 27;40(11):2215-2227. Epub 2020 Jan 27.

Weill Institute for Neurosciences,

Manipulations that enhance GABAergic inhibition have been associated with improved behavioral phenotypes in autism models, suggesting that autism may be treated by correcting underlying deficits of inhibition. Interneuron transplantation is a method for increasing recipient synaptic inhibition, and it has been considered a prospective therapy for conditions marked by deficient inhibition, including neuropsychiatric disorders. It is unknown, however, whether interneuron transplantation may be therapeutically effective only for conditions marked by reduced inhibition, and it is also unclear whether transplantation improves behavioral phenotypes solely by normalizing underlying circuit defects. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1063-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083289PMC

Changes in Brain Tissue Oxygenation and Metabolism During Rewarming After Neonatal Encephalopathy are Related to Electrical Abnormality.

Adv Exp Med Biol 2020 ;1232:25-31

Department of Medical Physics and Biomedical Engineering, University College London, London, UK.

Hypoxic ischemic encephalopathy (HIE) leads to significant mortality and morbidity, and therapeutic hypothermia (TH) has become a standard of care following HIE. After TH, the body temperature is brought back to 37 °C. Early electroencephalography (EEG) is a reliable outcome biomarker following HIE. Read More

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http://dx.doi.org/10.1007/978-3-030-34461-0_4DOI Listing
January 2020

Genetic diagnosis of neonatal-onset seizures.

Genes Dis 2019 Dec 8;6(4):441-447. Epub 2019 Feb 8.

The Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.

Many seizures in neonates are due to early-onset epilepsy, which is often difficult to diagnose, especially to explore the causes. Recently, the development of next-generation sequencing (NGS) has led to the discovery of a large number of genes involved in epilepsy. This may improve prompt detection of early-onset epilepsy in neonates. Read More

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http://dx.doi.org/10.1016/j.gendis.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888710PMC
December 2019

A standardised assessment scheme for conventional EEG in preterm infants.

Clin Neurophysiol 2020 01 9;131(1):199-204. Epub 2019 Nov 9.

INFANT Centre for Maternal and Child Health Research, Ireland; Department of Pediatrics and Child Health, University College Cork, Cork, Ireland; Department of Neonatology, Cork University Maternity Hospital, Wilton, Cork, Ireland. Electronic address:

Objective: To develop a standardised scheme for assessing normal and abnormal electroencephalography (EEG) features of preterm infants. To assess the interobserver agreement of this assessment scheme.

Methods: We created a standardised EEG assessment scheme for 6 different post-menstrual age (PMA) groups using 4 EEG categories. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.09.028DOI Listing
January 2020

The probability of seizures during continuous EEG monitoring in high-risk neonates.

Epilepsia 2019 12 19;60(12):2508-2518. Epub 2019 Nov 19.

Neurology, Massachusetts General Hospital, Boston, MA, USA.

Objective: We evaluated the impact of monitoring indication, early electroencephalography (EEG), and clinical features on seizure risk in all neonates undergoing continuous EEG (cEEG) monitoring following a standardized monitoring protocol.

Methods: All cEEGs from unique neonates 34-48 weeks postmenstrual age monitored from 1/2011-10/2017 (n = 291) were included. We evaluated the impact of cEEG monitoring indication (acute neonatal encephalopathy [ANE], suspicious clinical events [SCEs], or other high-risk conditions [OHRs]), age, medication status, and early EEG abnormalities (including the presence of epileptiform discharges and abnormal background continuity, amplitude, asymmetry, asynchrony, excessive sharp transients, and burst suppression) on time to first seizure and overall seizure risk using Kaplan-Meier survival curves and multivariable Cox proportional hazards models. Read More

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http://dx.doi.org/10.1111/epi.16387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083278PMC
December 2019

Abnormal arterial anatomy and an unexpected intracranial haemorrhage.

Authors:
Kieran Bannerman

Arch Dis Child Educ Pract Ed 2019 Oct 30. Epub 2019 Oct 30.

Neonatal Unit, Leeds General Infirmary, Leeds, UK

A baby boy was born at term by spontaneous vaginal delivery to non-consanguineous parents following an unremarkable pregnancy. He was admitted to his local neonatal intensive care unit shortly after birth following several episodes of eye-rolling, colour change and apnoea. He had bilateral parieto-occipital cephalohaematomata, scattered petechiae and intermittent hypotonia. Read More

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http://dx.doi.org/10.1136/archdischild-2019-317834DOI Listing
October 2019
1 Read

Neurodevelopmental outcome predictors of term newborns with neonatal seizures.

Rev Neurol 2019 Nov;69(9):370-376

Hospital de Santa Maria, Lisboa, Portugal.

Introduction: The concrete burden of neonatal seizures in neurodevelopmental outcome of term newborns is still unknown in literature. The aim of this study was to describe prognostic predictors in neonatal seizures.

Subjects And Methods: Observational prospective study of term neonates with clinical seizures from a tertiary center (2009-2018). Read More

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http://dx.doi.org/10.33588/rn.6909.2019209DOI Listing
November 2019
2 Reads

Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy.

Front Pediatr 2019 1;7:399. Epub 2019 Oct 1.

Neonatology, National Maternity Hospital, Dublin, Ireland.

Neonatal encephalopathy (NE) is associated with coagulation abnormalities. We aimed to investigate the serial alterations in coagulation profiles in term infants with NE and correlate with their clinical outcomes. This was a prospective cohort study in a tertiary referral, university-affiliated maternity hospital. Read More

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http://dx.doi.org/10.3389/fped.2019.00399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779697PMC
October 2019
1 Read

The epileptology of GNB5 encephalopathy.

Epilepsia 2019 11 20;60(11):e121-e127. Epub 2019 Oct 20.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Pathogenic variants in GNB5 cause an autosomal recessive neurodevelopmental disorder with neonatal sinus bradycardia. Seizures or epilepsy occurred in 10 of 22 previously reported cases, including 6 children from one family. We delineate the epileptology of GNB5 encephalopathy. Read More

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http://doi.wiley.com/10.1111/epi.16372
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http://dx.doi.org/10.1111/epi.16372DOI Listing
November 2019
8 Reads

Interrater Agreement Between Critical Care Providers for Background Classification and Seizure Detection After Implementation of Amplitude-Integrated Electroencephalography in Neonates, Infants, and Children.

J Clin Neurophysiol 2020 May;37(3):259-262

Pediatric Intensive Care Unit, University Hospital, Nantes, France.

Purposes: Amplitude-integrated EEG (aEEG) has been widely developed in neonatal intensive care unit, but few studies focused on pediatric intensive care unit. Furthermore, reliability of aEEG under real-life conditions is unknown.

Methods: Participants were nurses from a 12-bed pediatric intensive care unit in a referral university hospital in France. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000634DOI Listing
May 2020
3 Reads

Amplitude-integrated EEG in infants with neonatal abstinence syndrome.

J Neonatal Perinatal Med 2019 ;12(4):391-397

Department of Pediatrics, Division of Neonatology, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: To describe amplitude-integrated encephalogram (aEEG) characteristics of neonates with neonatal abstinence syndrome (NAS).

Methods: This is a prospective observational study. Newborns exposed to prenatal opioids and their gestational matched controls were included. Read More

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http://dx.doi.org/10.3233/NPM-1834DOI Listing
January 2019

Acute ataxia in children: Common causes and yield of diagnostic work-up in the era of varicella vaccination.

J Clin Neurosci 2019 Oct 18;68:146-150. Epub 2019 Jul 18.

Pediatric Neurology Unit, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

We aimed to identify the most common causes of acute ataxia in children in the era of widespread varicella vaccination and the yield of commonly used diagnostic work-up. This retrospective study reviewed the medical records of children who presented with ataxia of less than 72 h duration, over the last 12 years. Associated signs and symptoms, laboratory, EEG and neuroimaging studies, final diagnosis and clinical findings at discharge and during follow-up were studied. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.07.008DOI Listing
October 2019
4 Reads

Increased electroencephalography connectivity precedes epileptic spasm onset in infants with tuberous sclerosis complex.

Epilepsia 2019 08 12;60(8):1721-1732. Epub 2019 Jul 12.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Objective: To identify whether abnormal electroencephalography (EEG) connectivity is present before the onset of epileptic spasms (ES) in infants with tuberous sclerosis complex (TSC).

Methods: Scalp EEG recordings were collected prospectively in infants diagnosed with TSC in the first year of life. This study compared the earliest recorded EEG from infants prior to ES onset (n = 16) and from infants who did not develop ES (n = 28). Read More

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http://dx.doi.org/10.1111/epi.16284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687536PMC
August 2019
9 Reads

Early Amplitude-Integrated Electroencephalography Predicts Long-Term Outcomes in Term and Near-Term Newborns With Severe Hyperbilirubinemia.

Pediatr Neurol 2019 09 26;98:68-73. Epub 2019 Apr 26.

Henan Key Laboratory of Child Brain Injury, Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou, China; Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. Electronic address:

Background: We aimed to determine the predictive neurological prognostic value of early amplitude-integrated electroencephalography (aEEG) in term and near-term neonates with severe hyperbilirubinemia compared with cranial magnetic resonance imaging (MRI) and auditory brainstem response (ABR).

Methods: Infants of ≥35 weeks of gestation with severe hyperbilirubinemia (total serum bilirubin [TSB] ≥340 μmol/L) or with hyperbilirubinemia (TSB ≥257 μmol/L) in association with bilirubin-induced neurological dysfunction were recruited. All the subjects had an aEEG after being admitted to the neonatal intensive care unit, whereas cranial MRI and ABR were performed when TSB had come down to the normal range. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.04.015DOI Listing
September 2019
6 Reads
1.504 Impact Factor

[Association of peripheral blood pH early after birth with amplitude-integrated electroencephalography findings in neonates with intrauterine distress].

Zhongguo Dang Dai Er Ke Za Zhi 2019 May;21(5):454-457

Shenzhen Nanshan District Maternal and Child Health Hospital, Shenzhen, Guangdong 518000, China.

Objective: To study the association of peripheral blood pH early after birth with amplitude-integrated electroencephalography (aEEG) findings in neonates with intrauterine distress.

Methods: The clinical data of the neonates with intrauterine distress who were born from January 2017 to May 2018 were collected. According to peripheral blood pH within 30 minutes after birth, these neonates were divided into 3 groups: pH ≤7. Read More

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May 2019
4 Reads

Clinical study of 19 patients with SCN8A-related epilepsy: Two modes of onset regarding EEG and seizures.

Epilepsia 2019 05 26;60(5):845-856. Epub 2019 Apr 26.

Pediatric Neurology Department, Timone Children Hospital, Reference Center for Rare Epilepsies, APHM, Marseille, France.

Objective: To describe the mode of onset of SCN8A-related severe epilepsy in order to facilitate early recognition, and eventually early treatment with sodium channel blockers.

Methods: We reviewed the phenotype of patients carrying a mutation in the SCN8A gene, among a multicentric cohort of 638 patients prospectively followed by several pediatric neurologists. We focused on the way clinicians made the diagnosis of epileptic encephalopathy, the very first symptoms, electroencephalography (EEG) findings, and seizure types. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14727
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http://dx.doi.org/10.1111/epi.14727DOI Listing
May 2019
40 Reads

EEG Findings in Infants With Neonatal Abstinence Syndrome Presenting With Clinical Seizures.

Front Pediatr 2019 29;7:111. Epub 2019 Mar 29.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, KY, United States.

Neonatal abstinence syndrome (NAS) refers to a constellation of signs occurring in newborn infants who were exposed to opioids or opiates . These manifestations include poor feeding, gastrointestinal disorders, abnormal sleep patterns, and neurological signs such as jitteriness, tremors, and seizures (1, 2). Myoclonus, jitteriness, and tremors often may be interpreted as seizures and therefore treated as epileptic seizures. Read More

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http://dx.doi.org/10.3389/fped.2019.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449643PMC
March 2019
8 Reads

Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures.

J Child Neurol 2019 07 9;34(8):458-463. Epub 2019 Apr 9.

2 Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Many neonates with hypoxic ischemic encephalopathy and seizures do not respond to the first line antiepileptic drug, phenobarbital. Little is known about what factors are associated with its failure.

Objective: To examine factors associated with failure of phenobarbital therapy in neonates with hypoxic ischemic encephalopathy and seizures. Read More

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http://dx.doi.org/10.1177/0883073819838171DOI Listing
July 2019
7 Reads
1.666 Impact Factor

Paroxysmal spasticity of lower extremities as the initial symptom in two siblings with maple syrup urine disease.

Mol Med Rep 2019 Jun 5;19(6):4872-4880. Epub 2019 Apr 5.

Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.

Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder caused by mutations in genes that encode subunits of the branched‑chain α‑ketoacid dehydrogenase (BCKD) complex. Impairment of the BCKD complex results in an abnormal accumulation of branched‑chain amino acids and their corresponding branched‑chain keto acids in the blood and cerebrospinal fluid, which are neurovirulent and may become life‑threatening. An 11‑day‑old boy was admitted to the hospital with paroxysmal spasticity of lower extremities. Read More

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http://dx.doi.org/10.3892/mmr.2019.10133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522870PMC
June 2019
18 Reads

Value of MRI enhanced FLAIR sequence examination combined with CSF TNF-α detection in the early diagnosis of neonatal purulent meningitis.

Exp Ther Med 2019 Apr 22;17(4):3124-3128. Epub 2019 Feb 22.

Department of Neonatology, Linyi Women and Children's Hospital, Linyi, Shandong 276014, P.R. China.

This study aimed to investigate the value of MRI enhanced fluid-attenuated inversion recovery (FLAIR) combined with TNF-α in cerebrospinal fluid in the diagnosis of neonatal purulent meningitis. Fifty neonates with purulent meningitis were randomly selected in the purulency group, 50 patients with viral meningitis (VM) in the virus group and 50 neonates without purulent meningitis in the no meningitis group. All neonates were selected from April 2015 to May 2018 in Women and Children's Hospital (Linyi, China). Read More

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http://dx.doi.org/10.3892/etm.2019.7305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434275PMC
April 2019
6 Reads

Association of cerebral activity with MRI scans in infants with neonatal encephalopathy undergoing therapeutic hypothermia.

Eur J Pediatr 2019 Jun 21;178(6):851-861. Epub 2019 Mar 21.

Faculty of Health sciences, Ben Gurion University of the Negev, Be'er Sheva, Israel.

We aimed to correlate amplitude-integrated EEG (aEEG) in neonatal hypoxic ischemic encephalopathy (HIE) with early magnetic resonance imaging (MRI). In this retrospective study, 32 neonates over 35 weeks' gestation with moderate/severe HIE who were treated with hypothermia were included. Early MRI scans and daily aEEG background were categorized to mild/normal, moderate, and severely abnormal. Read More

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http://dx.doi.org/10.1007/s00431-019-03364-1DOI Listing
June 2019
12 Reads
1.983 Impact Factor

Randomized controlled trial protocol to improve multisensory neural processing, language and motor outcomes in preterm infants.

BMC Pediatr 2019 03 19;19(1):81. Epub 2019 Mar 19.

Nationwide Children's Hospital Division of Neonatology & Center for Perinatal Research, The Ohio State University, 5th floor; 575 Children's Crossroads, Columbus, OH, 43215, USA.

Background: Premature infants are at risk for abnormal sensory development due to brain immaturity at birth and atypical early sensory experiences in the Neonatal Intensive Care Unit. This altered sensory development can have downstream effects on other more complex developmental processes. There are currently no interventions that address rehabilitation of sensory function in the neonatal period. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1455-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423745PMC
March 2019
10 Reads

Identification of two novel TPK1 gene mutations in a Chinese patient with thiamine pyrophosphokinase deficiency undergoing whole exome sequencing.

J Pediatr Endocrinol Metab 2019 Mar;32(3):295-300

Associate Senior Physician and Associate Professor of Department of Neurology and Development, The Seventh Medical Center of PLA General Hospital, Beijing, China.

Background The mutations of thiamine pyrophosphokinase-1 (TPK1) gene have been frequently studied in some patients with thiamine metabolism dysfunction syndrome-5 (THMD5), while TPK1 mutations in Chinese patients have been investigated by only homozygous. A search of the literature on the mutations in the Chinese population currently published revealed that no reports of compound heterozygous mutations were reported. Here, we report a Chinese patient with compound heterozygous TPK1 mutations who underwent magnetic resonance imaging (MRI), whole exome sequencing (WES), molecular diagnosis, bioinformatics analysis, and three-dimensional (3D) protein structure analysis. Read More

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http://dx.doi.org/10.1515/jpem-2018-0363DOI Listing
March 2019
3 Reads

Predictive factors and prognostic value for status epilepticus in newborns.

Eur J Paediatr Neurol 2019 Mar 29;23(2):270-279. Epub 2019 Jan 29.

Epileptology, Sleep Disorders and Functional Pediatric Neurology, Member of ERN-EpiCARE; HFME, Hospices Civils de Lyon, 59 Boulevard Pinel, Bron, France.

Objectives: To evaluate the predictive factors for status epilepticus (SE) in neonates and prognostic factors for patient outcomes in newborns suffering either isolated seizures or SE.

Methods: A retrospective single-center study from January 2010 to December 2014, included 91 newborns who had neonatal seizures. Among them, 50 newborns experienced SE and 41 newborns presented isolated seizures only. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.006DOI Listing
March 2019
18 Reads

Amplitude-integrated EEG use in neonatal abstinence syndrome: a pilot study.

J Matern Fetal Neonatal Med 2019 Mar 1:1-6. Epub 2019 Mar 1.

e Department of Neurology , University of Wisconsin School of Medicine and Public Health , Madison , WI , USA.

Objective: Though central nervous system irritability is a well-established consequence of neonatal drug withdrawal, brain function in infants with neonatal abstinence syndrome (NAS) is not well understood. Amplitude-integrated electroencephalography (aEEG) is a bedside tool used for monitoring brain activity and seizures. We describe the prevalence of abnormal aEEG background patterns in infants with NAS. Read More

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http://dx.doi.org/10.1080/14767058.2019.1579190DOI Listing
March 2019
10 Reads

Lack of Variability in Cerebral Oximetry Tendency in Infants with Severe Hypoxic-Ischemic Encephalopathy Under Hypothermia.

Ther Hypothermia Temp Manag 2019 Dec 22;9(4):243-250. Epub 2019 Jan 22.

Fundación NeNe, Madrid, Spain.

Cerebral oximetry using near-infrared spectroscopy (NIRS) provides continuous, noninvasive assessment of the degree of hemoglobin saturation of the brain tissue. Previous studies suggest that high values of regional cerebral tissue oxygen saturation (rScO) during the first days in neonates with significant hypoxic-ischemic encephalopathy (HIE) are correlated with an adverse neurological outcome. However, the results are not consistent among the studies. Read More

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http://dx.doi.org/10.1089/ther.2018.0041DOI Listing
December 2019
25 Reads

Amplitude-Integrated Electroencephalography for Early Diagnosis and Prognostic Prediction of Hypoxic Encephalopathy in Preterm Infants.

Med Sci Monit 2018 Dec 5;24:8795-8802. Epub 2018 Dec 5.

Department of Child Health, Linyi Central Hospital, Linyi, Shandong, China (mainland).

BACKGROUND The aim of this study was to analyze amplitude-integrated electroencephalography (aEEG) in early diagnosis and prognosis of hypoxic encephalopathy (HE) in premature infants. MATERIAL AND METHODS Thirty-six premature infants with HE who were treated in Linyi Central Hospital were enrolled into the study group, while 40 premature infants without HE were assigned into the control group. aEEG was conducted within 6 h after delivery to compare aEEG continuity, mature sleep-wake cycle, and maximum and minimum voltage in the 2 groups. Read More

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http://dx.doi.org/10.12659/MSM.909330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290585PMC
December 2018
5 Reads

Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.

Lancet Neurol 2019 01 15;18(1):35-45. Epub 2018 Nov 15.

Centre for Perinatal Neuroscience, Imperial College London, London, UK. Electronic address:

Background: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance (MR) spectroscopy (MRS) biomarkers as early predictors of the neurodevelopmental abnormalities observed years after neonatal encephalopathy.

Methods: We did a prospective multicentre cohort study across eight neonatal intensive care units in the UK and USA, recruiting term and near-term neonates who received therapeutic hypothermia for neonatal encephalopathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183032
Publisher Site
http://dx.doi.org/10.1016/S1474-4422(18)30325-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291458PMC
January 2019
53 Reads

A Bayesian parametric model for quantifying brain maturation from sleep-EEG in the vulnerable newborn baby.

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:1-4

Newborn babies, particularly preterms, can exhibit early deviations in sleep maturation as seen by Electroencephalogram (EEG) recordings. This may be indicative of cognitive problems by school-age. The current 'clinically-driven' approach uses separate algorithms to first extract sleep states and then predict EEG 'brain-age'. Read More

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https://ieeexplore.ieee.org/document/8512185/
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http://dx.doi.org/10.1109/EMBC.2018.8512185DOI Listing
July 2018
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[Clinical and laboratory characteristics and genetic diagnosis of Kabuki syndrome].

Zhonghua Er Ke Za Zhi 2018 Nov;56(11):846-849

Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

To investigate the clinical features, laboratory characteristics and genetic diagnosis of Kabuki syndrome (KS). Between September 2014 and September 2016, seven children with clinically diagnosed KS from the neurology department, Beijing Children Hospital, Capital Medical University were included in this study. Three of them were male and 4 were female aged from 19 days to 6 years and 4 months with a median age of 3 years and 1 month. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.11.010DOI Listing
November 2018
30 Reads

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling.

J Vis Exp 2018 10 11(140). Epub 2018 Oct 11.

Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health;

Sleep is critical for proper development and neural plasticity. Moreover, abnormal sleep patterns are characteristic of many neurodevelopmental disorders. Studying how chronic sleep restriction during development can affect adult behavior may add to our understanding of the emergence of behavioral symptoms of neurodevelopmental disorders. Read More

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https://www.jove.com/video/58150/chronic-sleep-deprivation-i
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http://dx.doi.org/10.3791/58150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235482PMC
October 2018
32 Reads

Clinical and neuropsychological outcomes for children with phenylketonuria in Upper Egypt; a single-center study over 5 years.

Neuropsychiatr Dis Treat 2018 5;14:2551-2561. Epub 2018 Oct 5.

Public Health and Community Medicine Department, Faculty of Medicine, Sohag University, Sohag, Egypt.

Background: Phenylketonuria (PKU) is considered to be a rare inborn error of metabolism but one of the commonest causes of mental retardation if untreated.

Objectives: The present study was done to characterize the clinical patterns of PKU and analyze various neuropsychiatric outcomes in PKU children in Sohag Province, Egypt.

Patients And Methods: A prospective cohort study was conducted on 113 PKU patients, diagnosed during the period from 2012 to 2017, at the Pediatric Neurology Clinic of Sohag University Hospital, Upper Egypt. Read More

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https://www.dovepress.com/clinical-and-neuropsychological-ou
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http://dx.doi.org/10.2147/NDT.S176198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179721PMC
October 2018
34 Reads
2.154 Impact Factor

Electroencephalography and brain magnetic resonance imaging in asphyxia comparing cooled and non-cooled infants.

Eur J Paediatr Neurol 2019 Jan 12;23(1):181-190. Epub 2018 Sep 12.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands; Department of Pediatrics, Division of Neonatology, Wilhelmina Children's Hospital, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands. Electronic address:

Objective: The aim was to establish any differences in the predictive value of EEG and MRI for outcome in infants treated and not-treated with therapeutic hypothermia (HT) for perinatal asphyxia. We hypothesize that they are equally predictive and that combining both has the highest predictive value.

Study Design: We retrospectively compared data of infants with hypoxic-ischemic encephalopathy (HIE) who received HT (n = 45) between September 2009 and December 2013 with those of infants with HIE born between January 2004 and August 2009, before HT was available (NT, n = 37). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.001DOI Listing
January 2019
10 Reads
1.934 Impact Factor

Predictive Value of Midline Spikes on Pediatric EEG for Seizure and Developmental Outcome.

J Clin Neurophysiol 2018 Nov;35(6):490-495

Department of Pediatrics, Division of Neurology, BC Children's Hospital, Vancouver, Canada.

Purpose: Midline spikes are epileptiform discharges localized to the midsagittal regions of the brain. Isolated midline spikes are rare, but more common in children. Our objective was to determine whether midline spikes are predictive of seizure characteristics and neurodevelopment. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000516DOI Listing
November 2018
21 Reads
1.600 Impact Factor

Evaluation of the efficacy of amplitude-integrated electroencephalography in the screening of newborns with metabolic disorder admitted to the NICU.

BMC Med Imaging 2018 09 20;18(1):33. Epub 2018 Sep 20.

Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Neonate patients with metabolic disorder show encephalopathy and seizures that may lead to morbidity and mortality. Thus rapid detection and treatment of these patients is necessary. Although Amplitude-integrated electroencephalography (aEEG) has been used for more than a decade in the evaluation of infants with encephalopathy but has not been used in the assessment of neonates suffering from metabolic disorders. Read More

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http://dx.doi.org/10.1186/s12880-018-0274-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148992PMC
September 2018
12 Reads

Early Retinal Findings Following Cooling in Neonatal Encephalopathy.

Neuropediatrics 2019 02 20;50(1):15-21. Epub 2018 Sep 20.

Department of Neonatology, UCL EGA Institute for Women's Health (IfWH), University College London, London, United Kingdom.

Background And Aim: Perinatal HI (hypoxia-ischemia)-related visual defects including blindness are known to be associated with ischemic lesions in intracerebral visual pathways and ischemic retinal damage (IRD). Intraocular hemorrhages (IOH) such as retinal hemorrhage (RH), which may result from perinatal HI, can cause IRD by various mechanisms. We aimed to evaluate the early retinal findings in neonates with moderate-to-severe neonatal encephalopathy (NE) who underwent TH and its relationship between coagulation status, amplitude-integrated electroencephalography (aEEG) patterns, and magnetic resonance imaging-magnetic resonance spectroscopy (MRI-MRS) findings. Read More

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http://dx.doi.org/10.1055/s-0038-1669425DOI Listing
February 2019
15 Reads

High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy.

Seizure 2018 Oct 11;61:221-226. Epub 2018 Sep 11.

Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States; Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

Purpose: Electroencephalographic seizures (ES) are common among neonates with hypoxic-ischemic encephalopathy (HIE), and they represent a treatable complication that might improve neurodevelopmental outcomes. We aimed to establish whether higher ES exposure was predictive of unfavorable outcomes while adjusting for other important clinical and electroencephalographic parameters.

Methods: We performed a single-center, retrospective study of consecutive neonates with HIE managed with therapeutic hypothermia from June 2010 through December 2016. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168337PMC
October 2018
13 Reads

Clinical characteristics and aetiology of early childhood epilepsy: a single centre experience in Saudi Arabia.

Sudan J Paediatr 2018 ;18(1):57-62

Paediatric Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Seizures in children and neonatal period have variety of causes; however, most of childhood seizures are idiopathic. The aim of this study was to review the causes of epilepsy in children presenting in the first 2 years of life using the International League Against Epilepsy classification released in 2010. This was a retrospective chart review study that was conducted at a tertiary center in Saudi Arabia. Read More

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http://dx.doi.org/10.24911/SJP.2018.1.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113787PMC
January 2018
15 Reads

Amplitude-Integrated Electroencephalography for Early Recognition of Brain Injury in Neonates with Critical Congenital Heart Disease.

J Pediatr 2018 11 22;202:199-205.e1. Epub 2018 Aug 22.

Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands. Electronic address:

Objective: To study perioperative amplitude-integrated electroencephalography (aEEG) as an early marker for new brain injury in neonates requiring cardiac surgery for critical congenital heart disease (CHD).

Study Design: This retrospective observational cohort study investigated 76 neonates with critical CHD who underwent neonatal surgery. Perioperative aEEG recordings were evaluated for background pattern (BGP), sleep-wake cycling (SWC), and ictal discharges. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.06.048DOI Listing
November 2018
24 Reads

Prediction of Response to Treatment in Children with Epilepsy.

Iran J Child Neurol 2018 ;12(3):94-100

Child Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs.

Material And Methods: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The inclusion criteria were children 2 months to 12 yr of age with epilepsy and patients who experienced fever and seizure attacks at least once were excluded from the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045937PMC
January 2018
32 Reads

Cranial ultrasound and neurophysiological testing to predict neurological outcome in infants born very preterm.

Dev Med Child Neurol 2018 12 7;60(12):1232-1238. Epub 2018 Jul 7.

Department of Neonatology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Aim: Infants born preterm are at risk of cerebral palsy (CP) and motor or cognitive developmental delay. For clinicians, it is essential to know the relative predictive accuracy of the most commonly used neuroimaging and neurophysiological tests for the early prediction of adverse neurodevelopmental outcome. The aim of this study was to compare the accuracy of these tests in survivors of a population of infants born very preterm. Read More

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http://dx.doi.org/10.1111/dmcn.13961DOI Listing
December 2018
10 Reads

Early Amplitude-Integrated Electroencephalogram as a Predictor of Brain Injury in Newborns With Very Low Birth Weight: A Cohort Study.

J Child Neurol 2018 09 13;33(10):659-663. Epub 2018 Jun 13.

1 Postgraduate Program in Child and Adolescent Health, UFRGS, Porto Alegre, Brazil.

Purpose: To evaluate the relationship between abnormal early amplitude integrated electroencephalography (EEG) and severe lesions in imaging tests performed during the neonatal period in very low birth weight infants.

Methods: An amplitude-integrated EEG was performed in 70 patients with a mean birth weight of 1226 g during the first 48 hours of life. Severe lesions on magnetic resonance imaging (MRI) or ultrasonography (US) during the neonatal period were considered as adverse conditions. Read More

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http://dx.doi.org/10.1177/0883073818778468DOI Listing
September 2018
36 Reads

Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.

Pediatr Res 2018 09 3;84(3):399-402. Epub 2018 May 3.

Departments of Neurology and Pediatrics, University of California San Francisco, California, USA.

Objectives: To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia.

Methods: We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8. Read More

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http://dx.doi.org/10.1038/s41390-018-0040-xDOI Listing
September 2018
4 Reads