847 results match your criteria Abnormal Neonatal EEG

Changes in amplitude-integrated electroencephalography, neuron-specific enolase, and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia and their significance.

Brain Inj 2021 Jun 7:1-6. Epub 2021 Jun 7.

Department of Pediatrics, Xuzhou Central Hospital (Xuzhou Clinical School of Xuzhou Medical University), Xuzhou, China.

: To explore the changes in amplitude-integrated electroencephalography (aEEG), neuron-specific enolase (NSE), and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia (NHB).: 67 neonates with brain injury induced by NHB admitted to our hospital from March 2016 to October 2018 were included in a brain injury group (BIG), and 82 neonates with NHB but without brain injury in our hospital during the same period were included in a non-BIG. The two groups were compared regarding the rates of normal and abnormal aEEG results. Read More

View Article and Full-Text PDF

Risk factors affecting seizure recurrence in childhood epilepsy during short-term follow-up.

Childs Nerv Syst 2021 May 28. Epub 2021 May 28.

Department of Pediatrics, Faculty of Medicine, Training and Research Hospital, Bolu Abant Izzet Baysal University, Bolu, Turkey.

Purpose: The aim of this study is to examine the factors affecting seizure recurrence in pediatric patients diagnosed with epilepsy.

Methods: Three hundred patients presenting to the pediatric neurology clinic between 2015 and 2018 and diagnosed with epilepsy and treated with single antiseizure drug were included in the study. Medical histories and clinical and laboratory findings were retrieved retrospectively from the hospital data system. Read More

View Article and Full-Text PDF

AUTS2 Regulates RNA Metabolism and Dentate Gyrus Development in Mice.

Cereb Cortex 2021 May 19. Epub 2021 May 19.

Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Human AUTS2 mutations are linked to a syndrome of intellectual disability, autistic features, epilepsy, and other neurological and somatic disorders. Although it is known that this unique gene is highly expressed in developing cerebral cortex, the molecular and developmental functions of AUTS2 protein remain unclear. Using proteomics methods to identify AUTS2 binding partners in neonatal mouse cerebral cortex, we found that AUTS2 associates with multiple proteins that regulate RNA transcription, splicing, localization, and stability. Read More

View Article and Full-Text PDF

Short-term outcomes in infants with mild neonatal encephalopathy: a retrospective, observational study.

BMC Pediatr 2021 05 7;21(1):224. Epub 2021 May 7.

Department of Neonatology, Tokyo Metropolitan Children's Medical Center, 2-8-9 Musashidai, Fuchu, 183-8561, Tokyo, Japan.

Background: Neonatal encephalopathy due to acute perinatal asphyxia is a major cause of perinatal brain damage. Moderate to severe neonatal encephalopathy is associated with high mortality and morbidity rates. However, the neurodevelopmental outcomes in neonates with mild neonatal encephalopathy are unclear. Read More

View Article and Full-Text PDF

A Decision-Tree Approach to Assist in Forecasting the Outcomes of the Neonatal Brain Injury.

Int J Environ Res Public Health 2021 04 30;18(9). Epub 2021 Apr 30.

Dental and Nursing Medical Department, Faculty of Medicine, Lucian Blaga University Sibiu, 550169 Sibiu, Romania.

Neonatal brain injury or neonatal encephalopathy (NE) is a significant morbidity and mortality factor in preterm and full-term newborns. NE has an incidence in the range of 2.5 to 3. Read More

View Article and Full-Text PDF

Use of Therapeutic Hypothermia in Sudden Unexpected Postnatal Collapse: A Retrospective Study.

Acta Med Port 2020 Sep 28. Epub 2020 Sep 28.

Serviço de Neonatologia. Departamento de Pediatria. Hospital de Santa Maria. Centro Hospitalar Universitário Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Sudden and unexpected postnatal collapse is a rare event with potentially dramatic consequences. Intervention approaches are limited, but hypothermia has been considered after postnatal collapse. The aim of this study was to analyse sudden and unexpected postnatal collapse cases that underwent therapeutic hypothermia in the five Portuguese hypothermia centres. Read More

View Article and Full-Text PDF
September 2020

Multichannel EEG abnormalities during the first 6 hours in infants with mild hypoxic-ischaemic encephalopathy.

Pediatr Res 2021 Apr 20. Epub 2021 Apr 20.

INFANT Research Centre, Cork, Ireland.

Background: Infants with mild HIE are at risk of significant disability at follow-up. In the pre-therapeutic hypothermia (TH) era, electroencephalography (EEG) within 6 hours of birth was most predictive of outcome. This study aims to identify and describe features of early EEG and heart rate variability (HRV) (<6 hours of age) in infants with mild HIE compared to healthy term infants. Read More

View Article and Full-Text PDF

Can EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?

Arch Dis Child Fetal Neonatal Ed 2021 Apr 19. Epub 2021 Apr 19.

INFANT Research Centre, University College Cork, Ireland

Objective: Establish if serial, multichannel video electroencephalography (EEG) in preterm infants can accurately predict 2-year neurodevelopmental outcome.

Design And Patients: EEGs were recorded at three time points over the neonatal course for infants <32 weeks' gestational age (GA). Monitoring commenced soon after birth and continued over the first 3 days. Read More

View Article and Full-Text PDF

Association of Routinely Measured Proinflammatory Biomarkers With Abnormal MRI Findings in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.

Front Pediatr 2021 29;9:624652. Epub 2021 Mar 29.

Department of Pediatrics I/Neonatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

The neuroprotective treatment effect of therapeutic hypothermia (TH) following perinatal asphyxia may be negatively influenced by neonatal sepsis and concomitant inflammation. We aimed to correlate routinely used blood biomarkers for perinatal sepsis in cooled asphyxiated newborns with MRI findings. Perinatal data was retrospectively collected from 67 cooled asphyxiated newborns. Read More

View Article and Full-Text PDF

Clinical seizures and unfavorable brain MRI patterns in neonates with hypoxic ischemic encephalopathy.

Medicine (Baltimore) 2021 Mar;100(12):e25118

Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract: The aim was to examine whether clinical seizures and amplitude-integrated electroencephalogram (aEEG) patterns in infants with hypoxic ischemic encephalopathy (HIE) can predict the extent of brain injury on magnetic resonance images (MRI) and the long-term neurodevelopmental outcomes at 18∼24 months of age.HIE infants who underwent therapeutic hypothermia (TH) between June 2014 and March 2017 were included in this study. Infants with clinical seizure were analyzed for aEEG patterns and the extent of brain injury on MRI findings. Read More

View Article and Full-Text PDF

Neuromonitoring in Neonatal-Onset Epileptic Encephalopathies.

Regina Trollmann

Front Neurol 2021 2;12:623625. Epub 2021 Feb 2.

Department of Pediatrics and Pediatric Neurology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Considering the wide spectrum of etiologies of neonatal-onset epileptic encephalopathies (EE) and their unfavorable consequences for neurodevelopmental prognoses, neuromonitoring at-risk neonates is increasingly important. EEG is highly sensitive for early identification of electrographic seizures and abnormal background activity. Amplitude-integrated EEG (aEEG) is recommended as a useful bedside monitoring method but as a complementary tool because of methodical limitations. Read More

View Article and Full-Text PDF
February 2021

Neonatal Seizures and Future Epilepsy: Predictive Value of Perinatal Risk Factors, Electroencephalography, and Imaging.

J Pediatr Neurosci 2020 Jul-Sep;15(3):190-198. Epub 2020 Nov 6.

Department of Pediatrics & Neonatology, Gazi University School of Medicine, Ankara, Turkey.

Context: There are limited data in the literature about the relationship between neonatal seizures and subsequent epilepsy.

Aims: This study aimed to identify the predictive value of perinatal factors, etiologies, electroencephalography (EEG), and cranial ultrasonography (USG) for future epilepsy after neonatal seizures.

Materials And Methods: A total of 92 children with epilepsy who had seizures during their neonatal period were retrospectively evaluated whether the contribution of perinatal, natal, and postnatal risk factors confining clinical, laboratory, EEG, and imaging to subsequent epilepsy. Read More

View Article and Full-Text PDF
November 2020

Infants routine video electroencephalogram findings in a Saudi tertiary hospital.

Neurosciences (Riyadh) 2020 Oct;25(5):350-355

National Neuroscience Institute, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail:

Objective: To report the existence and describe the non-epileptic abnormalities, interictal epileptiform discharges, and seizures in routine electroencephalograms (EEGs) of infants in a tertiary hospital out-patient neurophysiology clinics.

Methods: This is a non-interventional, retrospective descriptive study that involved the review of 172 infants` EEGs conducted from July 2018 to June 2019 in King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.

Results: Total of 172 EEGs were reviewed; 152 routine EEGs for infants and 20 neonatal EEGs. Read More

View Article and Full-Text PDF
October 2020

Quantitative approach to early neonatal EEG visual analysis in hypoxic-ischemic encephalopathy severity: Bridging the gap between eyes and machine.

Neurophysiol Clin 2021 Mar 2;51(2):121-131. Epub 2021 Jan 2.

EA4489, Environnement périnatal et santé, Faculté de médecine, Université de Lille, 2 Avenue Eugène Avinée, 59120 Loos, France; Service de Neurologie pédiatrique, Hôpital Roger Salengro, CHRU de Lille, Avenue du Professeur Emile Laine, 59037, France.

Objectives: To identify relevant quantitative parameters for early classification of neonatal hypoxic-ischemic encephalopathy (HIE) severity from conventional EEGs.

Methods: Ninety EEGs, recorded in full-term infants within 6 h of life after perinatal hypoxia, were visually classified according to the French EEG classification into three groups of increasing HIE severity. Physiologically significant EEG features (signal amplitude, continuity and frequency content) were automatically quantified using different parameters. Read More

View Article and Full-Text PDF

Analysis of Clinical Related Factors of Neonatal Hand-Foot-Mouth Disease Complicated With Encephalitis.

Front Neurol 2020 12;11:543013. Epub 2020 Nov 12.

Zhangzhou Hospital Affiliated to Fujian Medical University, Zhangzhou, China.

To explore the clinical related factors of neonatal hand-foot-mouth disease (HFMD) complicated with encephalitis. The neonatal HFMD complicated with encephalitis treated in our hospital from July 2015 to July 2020 was taken as the object of study. According to the NBNA score at discharge, the patients were divided into normal group and abnormal group. Read More

View Article and Full-Text PDF
November 2020

Magnetic Resonance Imaging and Histopathologic Findings From a Standard Poodle With Neonatal Encephalopathy With Seizures.

Front Vet Sci 2020 10;7:578936. Epub 2020 Nov 10.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Neonatal encephalopathy with seizures (NEwS) is an epileptic encephalopathy with an autosomal recessive inheritance pattern found in Standard Poodle puppies. The causal genetic variant for NEwS has been identified as a homozygous missense mutation in (c.152T>G, p. Read More

View Article and Full-Text PDF
November 2020

Risk for infantile spasms after acute symptomatic neonatal seizures.

Epilepsia 2020 12 13;61(12):2774-2784. Epub 2020 Nov 13.

Division of Pediatric Neurology, Department of Pediatrics, Michigan Medicine/University of Michigan, Ann Arbor, MI, USA.

Objective: Infantile spasms (IS) is a severe epilepsy in early childhood. Early treatment of IS provides the best chance of seizure remission and favorable developmental outcome. We aimed to develop a prediction rule to accurately predict which neonates with acute symptomatic seizures will develop IS. Read More

View Article and Full-Text PDF
December 2020

Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study.

Seizure 2020 Dec 29;83:154-159. Epub 2020 Oct 29.

Neonatology and Neonatal Intensive Care Unit, San Salvatore Hospital, Via Vetoio 67100 L'Aquila, Italy. Electronic address:

Objective: To examine the relationship between electrographic seizures and developmental outcome at 18 and 24 months in neonates with moderate and severe hypoxic-ischemic encephalopathy [HIE] treated with therapeutic hypothermia [TH].

Study Design: 30 term infants with moderate-severe HIE treated with TH were enrolled prospectively from June 2012 to May 2018. All had continuous single channel amplitude integrated EEG (aEEG) monitoring for a minimum of 72 h and brain MR within 4 weeks. Read More

View Article and Full-Text PDF
December 2020

[Effect of blood glucose on quantitative electroencephalography parameters in preterm infants].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Oct;22(10):1066-1072

Department of Neonatology, Third Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To study the value of quantitative electroencephalography (qEEG) in evaluating the effect of blood glucose on the brain function of preterm infants.

Methods: The preterm infants who were admitted to the Department of Neonatology, The Third Xiangya Hospital of Central South University, from January to December 2019 were enrolled. According to the level of blood glucose, they were divided into group 1 (blood glucose <4. Read More

View Article and Full-Text PDF
October 2020

Dyskinesia Impairment Scale scores in Dutch pre-school children after neonatal therapeutic hypothermia.

Eur J Paediatr Neurol 2020 Sep 5;28:70-76. Epub 2020 Aug 5.

Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, the Netherlands. Electronic address:

Background: Neonatal therapeutic hypothermia (TH) can ameliorate or prevent the development of dyskinetic cerebral palsy (CP) after hypoxic-ischemic encephalopathy (HIE). The Dyskinesia Impairment Scale (DIS) was recently launched to quantify dyskinetic (dystonic and choreatic) motor features in patients with CP. In TH treated children, who are at risk of developing dyskinetic CP, we aimed to determine DIS-scores at pre-school age. Read More

View Article and Full-Text PDF
September 2020

Does the first hour of continuous electroencephalography predict neonatal seizures?

Arch Dis Child Fetal Neonatal Ed 2021 Mar 14;106(2):162-167. Epub 2020 Sep 14.

The Department of Paediatric Neurology, Starship Children's Health, Newmarket, New Zealand.

Objective: Prolonged continuous video-electroencephalography (cEEG) is recommended for neonates at risk of seizures. The cost and expertise required to provide a real-time response to detected seizures often limits its utility. We hypothesised that the first hour of cEEG could predict subsequent seizures. Read More

View Article and Full-Text PDF

Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling.

Clin Exp Pediatr 2021 Apr 27;64(4):180-187. Epub 2020 Aug 27.

Neurosurgery Research Group (NRG), Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Severe perinatal asphyxia results in multiple organ involvement, neonate hospitalization, and eventual death.

Purpose: This study aimed to investigate the predictive factors of death in newborns with hypoxic-ischemic encephalopathy (HIE) receiving selective head cooling.

Methods: This cross-sectional descriptive-retrospective study was conducted from 2013 to 2018 in Fatemieh Hospital of Hamadan and included 51 newborns who were admitted to the neonatal intensive care unit with a diagnosis of HIE. Read More

View Article and Full-Text PDF

Up-Regulation of Nfat5 mRNA and Fzd4 mRNA as a Marker of Poor Outcome in Neonatal Hypoxic-Ischemic Encephalopathy.

J Pediatr 2021 01 20;228:74-81.e2. Epub 2020 Aug 20.

INFANT Research Centre, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; National Children's Research Centre, Crumlin, Dublin, Ireland.

Objective: To evaluate umbilical cord messenger RNA (mRNA) expression as biomarkers for the grade of hypoxic-ischemic encephalopathy (HIE) and long-term neurodevelopment outcome.

Study Design: Infants were recruited from the BiHiVE1 study, Ireland (2009-2011), and the BiHiVE2 study, Ireland, and Sweden (2013-2015). Infants with HIE were assigned modified Sarnat scores at 24 hours and followed at 18-36 months. Read More

View Article and Full-Text PDF
January 2021

Low Variability of Blood Pressure Predicts Abnormal Electroencephalogram in Infants with Hypoxic Ischemic Encephalopathy.

Am J Perinatol 2020 Aug 20. Epub 2020 Aug 20.

Department of Pediatrics, Washington University St. Louis, St. Louis, Missouri.

Objective:  This study aimed to evaluate the role of an objective physiologic biomarker, arterial blood pressure variability, for the early identification of adverse short-term electroencephalogram (EEG) outcomes in infants with hypoxic-ischemic encephalopathy (HIE).

Study Design:  In this multicenter observational study, we analyzed blood pressure of infants meeting these criteria: (1) neonatal encephalopathy determined by modified Sarnat exam, (2) continuous mean arterial blood pressure (MABP) data between 18 and 27 hours after birth, and (3) continuous EEG performed for at least 48 hours. Adverse outcome was defined as moderate-severe grade EEG at 48 hours. Read More

View Article and Full-Text PDF

Effect of perioperative amplitude-integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery.

Exp Ther Med 2020 Sep 13;20(3):2879-2887. Epub 2020 Jul 13.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

The purpose of the current study was to determine the effect of perioperative amplitude-integrated electroencephalography (aEEG) on neurodevelopmental outcomes in infants with congenital heart disease (CHD). A total of 93 children with CHD were included in the current study. All patients enrolled in the present study had undergone cardiac surgery prior to 3 months of age and pre- or postoperative aEEG was monitored. Read More

View Article and Full-Text PDF
September 2020

Phenotypic spectrum of patients with GABRB2 variants: from mild febrile seizures to severe epileptic encephalopathy.

Dev Med Child Neurol 2020 10 20;62(10):1213-1220. Epub 2020 Jul 20.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Aim: To characterize the different phenotypes of GABRB2-related epilepsy and to establish a genotype-phenotype correlation.

Method: We used next-generation sequencing to identify GABRB2 variants in 15 patients.

Results: Eleven GABRB2 variants were novel and 12 were de novo. Read More

View Article and Full-Text PDF
October 2020

Seizure-like events leading to hospital referrals in infants: A retrospective population-based study.

Acta Paediatr 2021 02 24;110(2):584-593. Epub 2020 Jul 24.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Aim: To identify the aetiology and outcome of seizure-like events leading to hospital referrals in infants and to identify early predictors of epilepsy and delayed neurodevelopment.

Methods: This Norwegian population-based study focused on all children born in Sør-Trøndelag county, who were up to one year of age in 2014-2015. They were identified by diagnostic codes for seizure-like events and electroencephalography (EEG) examinations. Read More

View Article and Full-Text PDF
February 2021

EEG features of brain injury during extracorporeal membrane oxygenation in children.

Neurology 2020 09 6;95(10):e1372-e1380. Epub 2020 Jul 6.

From the Division of Epilepsy and Neurophysiology (A.J.S., M.L.D., T.L. , P.L.P., M.H.L.), Department of Anesthesiology, Critical Care and Pain Medicine (A.A.-A., R.C.T.), Department of Neurology (K.L., T.L., M.J.R., P.L.P., M.H.L., R.C.T.), Department of Psychiatry and Radiology (M.J.R.), and Department of Cardiology, Division of Cardiovascular Critical Care (R.R.T.), Boston Children's Hospital, MA.

Objective: To examine EEG features of major pathophysiology in children undergoing extracorporeal membrane oxygenation (ECMO).

Methods: This was a single-center, retrospective study of 201 pediatric patients on ECMO, using the first 24 hours of continuous EEG (cEEG) monitoring, collating background activity and electrographic seizures (ES) with imaging, ECMO type, and outcome.

Results: Severely abnormal cEEG background occurred in 12% (25/201), and was associated with death (sensitivity 0. Read More

View Article and Full-Text PDF
September 2020

Identification of neuronal structures and pathways corresponding to clinical functioning in galactosemia.

J Inherit Metab Dis 2020 11 3;43(6):1205-1218. Epub 2020 Aug 3.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Classic galactosemia (OMIM# 230400) is an autosomal recessive disorder due to galactose-1-phosphate uridyltransferase deficiency. Newborn screening and prompt treatment with a galactose-free diet prevent the severe consequences of galactosemia, but clinical outcomes remain suboptimal. Five men and five women with classic galactosemia (mean age = 27. Read More

View Article and Full-Text PDF
November 2020