892 results match your criteria Abnormal Neonatal EEG


Electroencephalogram background and head ultrasound together stratify seizure risk in neonates undergoing hypothermia.

Epilepsy Behav 2022 Jun 22;133:108784. Epub 2022 Jun 22.

Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232, USA. Electronic address:

The benefits of continuous electroencephalography (cEEG) monitoring in the intensive care unit (ICU) are increasingly appreciated, though expanding indications for cEEG may strain resources. The current standard of care in babies with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH) includes cEEG monitoring throughout the entire TH and rewarming process (at least 72 h). Recent cEEG data demonstrate that most seizures occur within the first 24 h of monitoring. Read More

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Electrographic Seizures in Neonates with a High Risk of Encephalopathy.

Children (Basel) 2022 May 24;9(6). Epub 2022 May 24.

Study Group for Intensive and Integrated Care of Pediatric Central Nervous System, Department of Pediatrics (iCNS Study Group), Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.

Background: Neonatal encephalopathy is caused by a wide variety of acute brain insults in newborns and presents with a spectrum of neurologic dysfunction, such as consciousness disturbance, seizures, and coma. The increased excitability in the neonatal brain appears to be highly susceptible to seizures after a variety of insults, and seizures may be the first clinical sign of a serious neurologic disorder. Subtle seizures are common in the neonatal period, and abnormal clinical paroxysmal events may raise the suspicion of neonatal seizures. Read More

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Background suppression of electrical activity is a potential biomarker of subsequent brain injury in a rat model of neonatal hypoxia-ischemia.

J Neurophysiol 2022 Jun 8. Epub 2022 Jun 8.

Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, United States.

Electrographic seizures and abnormal background activity in the neonatal electroencephalogram (EEG) may differentiate between harmful versus benign brain insults. Using two animal models of neonatal seizures, electrical activity was recorded in freely behaving rats and examined quantitatively during successive time periods with field-potential recordings obtained shortly after the brain insult (i.e. Read More

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Neuropathology findings in KCNQ2 neonatal epileptic encephalopathy.

Seizure 2022 Jul 10;99:36-39. Epub 2022 May 10.

Université de Paris, AP-HP, Hôpital Robert-Debré, INSERM NeuroDiderot, DMU Innov-RDB, Neurologie Pédiatrique, Paris, France.

Purpose: KCNQ2-epileptic encephalopathy (EE) is a neonatal epilepsy syndrome characterized by a typical clinical presentation and EEG recording, but without any brain or cortical abnormal development on MRI. Most of the patients have a severe developmental impairment. The epileptogenic mechanisms are thought to be the result of the changes of the M-current density causing a change of brain excitability. Read More

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Serum neuron-specific enolase, magnetic resonance imaging, and electrophysiology for predicting neurodevelopmental outcomes of neonates with hypoxic-ischemic encephalopathy: a prospective study.

BMC Pediatr 2022 May 17;22(1):290. Epub 2022 May 17.

Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity. Effective indicators for the early diagnosis of brain injury after HIE and prognosis are lacking. This study aimed to examine the predictive value of serum neuron-specific enolase (NSE), amplitude-integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI), alone and in combination, for the neurological outcomes in neonates with HIE. Read More

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Phenotypic Spectrum in a Family Sharing a Heterozygous Variant.

J Child Neurol 2022 May 6;37(6):517-523. Epub 2022 Apr 6.

Department of Pediatrics, 12306The Ohio State University, Columbus, OH, USA.

Background And Purpose: Mutations in have classically been associated with benign familial neonatal and infantile seizures and more recently identified in patients with neurodevelopmental disorders and abnormal electroencephalogram (EEG) findings. We present 4 affected patients from a family with a pathogenic mutation in with a unique constellation of clinical findings.

Methods: A family of 3 affected siblings and mother sharing a pathogenic variant are described, including clinical history, genetic results, and EEG and magnetic resonance imaging (MRI) findings. Read More

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Neonatal seizures: stepping outside the comfort zone.

Clin Exp Pediatr 2022 04 4. Epub 2022 Apr 4.

Neonatal Intensive Care Unit, Mansoura University Children's Hospital, Mansoura, Egypt.

Seizures are the most common neurological disorders in newborns. Managing neonatal seizures is challenging, especially for neurologists who are not neonatal specialists. Acute brain injury during ischemic insult is a key component of seizure occurrence, while genetic and metabolic disorders play less prevalent but more severe roles. Read More

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Neonatal Seizures: Diagnostic Updates Based on New Definition and Classification.

Clin Exp Pediatr 2022 Apr 4. Epub 2022 Apr 4.

Department of Pediatrics, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong, Korea.

Neonatal seizures are the most common neurological symptoms caused by various etiologies in the neonatal period, but their diagnosis and treatment are challenging because their pathophysiology and electroclinical manifestations differ from those of patients in older age groups. Many seizures present as electrographic-only events without clinical signs or as obscure clinical manifestations that are difficult to distinguish from other neonatal behaviors. Accordingly, a new definition and classification of neonatal seizures was recently proposed by the International League Against Epilepsy Task Force on neonatal seizures, highlighting the role of electroencephalography in diagnosing and treating neonatal seizures. Read More

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Longitudinal analysis of electroencephalography pattern changes in an infant with Schaaf-Yang syndrome and a novel mutation in melanoma antigen L2 (MAGEL2).

Mol Genet Genomic Med 2022 06 28;10(6):e1932. Epub 2022 Mar 28.

Department of Pediatrics, Japanese Red Cross Society Wakayama Medical Center, Wakayama City, Japan.

Background: Schaaf-Yang syndrome (SYS) is a rare hereditary disease caused by truncating point mutations of the paternal allele of melanoma antigen L2 (MAGEL2), one of five protein-coding genes within the Prader-Willi syndrome (PWS) critical domain. SYS shares many clinical and molecular characteristics with PWS but has some distinct features, such as joint contractures and autism. Patients with PWS show abnormal electroencephalography (EEG) patterns. Read More

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Oxidative Stress and Indicators of Brain Damage Following Pediatric Heart Surgery.

Antioxidants (Basel) 2022 Feb 28;11(3). Epub 2022 Feb 28.

Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Pediatric cardiac surgery induces an increased oxidative stress (OS) response. Increased OS is associated with poor neurologic outcomes in neonatal populations with similar patterns of brain injury. We investigated OS and brain injury in infants undergoing heart surgery. Read More

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February 2022

A practical approach toward interpretation of amplitude integrated electroencephalography in preterm infants.

Eur J Pediatr 2022 Jun 8;181(6):2187-2200. Epub 2022 Mar 8.

Hospital for Sick Children, Toronto, Canada.

The developing preterm brain is vulnerable to injury, especially during periods of clinical instability; therefore, monitoring the brain may provide important information on brain health. Over the last 2 decades, a growing body of literature has been reported on preterm amplitude integrated electroencephalography (aEEG) with regards to normative data and associations with adverse outcomes. Despite this, the use of aEEG for preterm infants remains mostly a research tool with limited clinical applicability. Read More

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[Clinical and genetic spectrum of SCN2A gene associated epilepsy and episodic ataxia].

Zhonghua Er Ke Za Zhi 2022 Jan;60(1):51-55

Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China.

To explore the clinical manifestations and genetic characteristics of patients with epilepsy and episodic ataxia caused by SCN2A gene variation. The clinical data of seizure manifestation, imaging examination and genetic results of 5 patients with epilepsy and (or) episodic ataxia because of SCN2A gene variation admitted to the Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University from July 2017 to January 2021 were analyzed retrospectively. Among 5 patients, 4 were female and 1 was male. Read More

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January 2022

Disorders of Neuronal Migration/Organization Convey the Highest Risk of Neonatal Onset Epilepsy Compared With Other Congenital Brain Malformations.

Pediatr Neurol 2022 02 12;127:20-27. Epub 2021 Nov 12.

Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California; Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California. Electronic address:

Background: Although seizures in neonates are common and often due to acute brain injury, 10-15% are unprovoked from congenital brain malformations. A better understanding of the risk of neonatal-onset epilepsy by the type of brain malformation is essential for counseling and monitoring.

Methods: In this retrospective cohort study, we evaluated 132 neonates with congenital brain malformations and their risk of neonatal-onset epilepsy. Read More

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February 2022

Early aEEG can predict neurodevelopmental outcomes at 12 to 18 month of age in VLBWI with necrotizing enterocolitis: a cohort study.

BMC Pediatr 2021 12 20;21(1):582. Epub 2021 Dec 20.

Department of Neonatology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, 325027, Zhejiang, China.

Background: Studies have shown that neurological damage is common in necrotizing enterocolitis (NEC) survivors. The purpose of the study was to investigate the predictive value of amplitude-integrated electroencephalogram (aEEG) for neurodevelopmental outcomes in preterm infants with NEC.

Methods: Infants with NEC were selected, and the control group was selected based on 1:1-2 pairing by gestational age. Read More

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December 2021

Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.

JAMA Neurol 2021 12;78(12):1484-1493

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Importance: Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce.

Objective: To determine whether electrographic seizures are more likely to occur during rewarming compared with the preceding period and whether they are associated with abnormal outcomes in asphyxiated neonates receiving hypothermia therapy.

Design, Setting, And Participants: This prespecified nested cohort study of infants enrolled in the Optimizing Cooling (OC) multicenter Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network trial from December 2011 to December 2013 with 2 years' follow-up randomized infants to either 72 hours of cooling (group A) or 120 hours (group B). Read More

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December 2021

[Clinical analysis of 15 patients with epileptic spasms and focal seizures as a single ictal event in neonatal period].

Zhonghua Er Ke Za Zhi 2021 Dec;59(12):1055-1058

Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

To investigate the phenomenon of epileptic spasms (ES) and focal seizures (FS) in a single ictal event (FS-ES phenomenon) and to study the etiology, manifestations, and prognosis of this phenomenon. The data of the 15 neonates who had ES and FS in a single ictal event, according to video-electroencephalography (VEEG) recording in Department of Neonatology of Children's Hospital of Fudan University during the period of January 2018 to December 2019, was analyzed retrospectively. Of the 15 neonates, 7 were male and 8 were female. Read More

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December 2021

Neonatal Seizures: Core Concepts.

Neonatal Netw 2021 Nov;40(6):362-368

Seizures are the abnormal, excessive, synchronous discharge of cortical neurons that results in injury to the brain. Seizures presenting in the neonatal period may be the first and only clue to underlying neurological pathology. Despite advances in care, the mortality rate for infants experiencing neonatal seizures is still as high as 20 percent, with up to 65 percent of infants with seizures demonstrating significant morbidity. Read More

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November 2021

Value of amplitude-integrated electroencephalogram combined with quantitative indices of cranial magnetic resonance imaging in predicting short-term neurodevelopment in moderately and late preterm infants: a prospective study.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Oct;23(10):987-993

Department of Neonatology, Lianyungang Hospital Affiliated to Xuzhou Medical University, Lianyungang, Jiangsu 222002, China (Yin Q-G, Email:

Objectives: To study the association of amplitude-integrated electroencephalogram (aEEG) and the quantitative indices biparietal width (BPW) and interhemispheric distance (IHD) of cranial magnetic resonance imaging (cMRI) with short-term neurodevelopment in moderately and late preterm infants.

Methods: A total of 104 moderately and late preterm infants who were admitted to the neonatal intensive care unit from September 2018 to April 2020 were selected as the subjects for this prospective study. The Naqeeb method and sleep-wake cycling (SWC) were used for aEEG assessment within 72 hours after birth. Read More

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October 2021

Wavelet-based neurovascular coupling can predict brain abnormalities in neonatal encephalopathy.

Neuroimage Clin 2021 20;32:102856. Epub 2021 Oct 20.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Background: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of morbidity and mortality in neonates, but quantitative methods to predict outcomes early in their course of illness remain elusive. Real-time physiologic biomarkers of neurologic injury are needed in order to predict which neonates will benefit from therapies. Neurovascular coupling (NVC) describes the correlation of neural activity with cerebral blood flow, and the degree of impairment could predict those at risk for poor outcomes. Read More

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January 2022

Association of Increased Seizures During Rewarming With Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.

JAMA Neurol 2021 Oct 18. Epub 2021 Oct 18.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Importance: Compared with normothermia, hypothermia has been shown to reduce death or disability in neonatal hypoxic ischemic encephalopathy but data on seizures during rewarming and associated outcomes are scarce.

Objective: To determine whether electrographic seizures are more likely to occur during rewarming compared with the preceding period and whether they are associated with abnormal outcomes in asphyxiated neonates receiving hypothermia therapy.

Design, Setting, And Participants: This prespecified nested cohort study of infants enrolled in the Optimizing Cooling (OC) multicenter Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network trial from December 2011 to December 2013 with 2 years' follow-up randomized infants to either 72 hours of cooling (group A) or 120 hours (group B). Read More

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October 2021

[Genotypes and clinical features of neonatal-onset genetic epilepsy in 141 patients].

Zhonghua Er Ke Za Zhi 2021 Sep;59(9):767-771

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize the genotypes and clinical features of neonatal-onset genetic epilepsy. Patients (114 cases) with identified gene variants were collected from May 2013 to May 2019 in Peking University First Hospital, retrospectively. The genotype, clinical, electroencephalographic and neuroimaging characteristics were analyzed. Read More

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September 2021

Multiscale Entropy Analysis of Heart Rate Variability in Neonatal Patients with and without Seizures.

Bioengineering (Basel) 2021 Sep 9;8(9). Epub 2021 Sep 9.

Department of Information Engineering, Università degli Studi di Firenze, Via Santa Marta 3, 50139 Firenze, Italy.

The complex physiological dynamics of neonatal seizures make their detection challenging. A timely diagnosis and treatment, especially in intensive care units, are essential for a better prognosis and the mitigation of possible adverse effects on the newborn's neurodevelopment. In the literature, several electroencephalographic (EEG) studies have been proposed for a parametric characterization of seizures or their detection by artificial intelligence techniques. Read More

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September 2021

Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE).

BMC Pediatr 2021 09 18;21(1):410. Epub 2021 Sep 18.

Soochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, P.R. China.

Background: While great attention has been paid to motor and cognitive impairments in children with neonatal Hypoxic-Ischemic Encephalopathy (HIE), sleep related circadian rhythm problems, although commonly present, are often neglected. Subsequently, no early clinical indicators have been reported to correlate with sleep-related circadian dysfunction during development.

Methods: In this study, we first analyzed patterns of the amplitude integrated electroencephalogram (aEEG) in a cohort of newborns with various degrees of HIE. Read More

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September 2021

Development and validation of Auto-Neo-electroencephalography (EEG) to estimate brain age and predict report conclusion for electroencephalography monitoring data in neonatal intensive care units.

Ann Transl Med 2021 Aug;9(16):1290

Center for Molecular Medicine, Pediatric Research Institute, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Background: Electroencephalography (EEG) monitoring is widely used in neonatal intensive care units (NICUs). However, conventional EEG report generation processes are time-consuming and labor-intensive. Therefore, an automatic, objective, and comprehensive pipeline for brain age estimation and EEG report conclusion prediction is urgently needed to assist clinician's decision-making. Read More

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Early Use of Transcranial Doppler Ultrasonography to Stratify Neonatal Encephalopathy.

Pediatr Neurol 2021 11 8;124:33-39. Epub 2021 Jul 8.

Neonatal-Perinatal Medicine, University of Texas Southwestern, Dallas, Texas. Electronic address:

Background: The dynamic nature of neonatal hypoxic-ischemic encephalopathy (HIE) after birth necessitates reliable biomarkers to identify infants with evolving brain injury. This prospective cohort aims to use serial Doppler ultrasonography (US) to measure cerebral blood flow velocity and resistance index (RI) to help detect the time and evolution of the clinical encephalopathy.

Methods: A total of 60 neonates were enrolled all ≥36 weeks' gestation with perinatal acidemia, defined as a blood gas pH ≤ 7. Read More

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November 2021

Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity.

Mol Ther Methods Clin Dev 2021 Sep 16;22:196-209. Epub 2021 Jul 16.

Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3M2.

Fragile X syndrome (FXS), a neurodevelopmental disorder with no known cure, is caused by a lack of expression of the fragile X mental retardation protein (FMRP). As a single-gene disorder, FXS is an excellent candidate for viral-vector-based gene therapy, although that is complicated by the existence of multiple isoforms of FMRP, whose individual cellular functions are unknown. We studied the effects of rat and mouse orthologs of human isoform 17, a major expressed isoform of FMRP. Read More

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September 2021

EEG Pattern in Neonatal Maple Syrup Urine Disease: Description and Clinical Significance.

Neurodiagn J 2021 Sep 27;61(3):123-131. Epub 2021 Aug 27.

Department of Child Health, College of Medicine and Health SciencesSultan Qaboos University Muscat, Sultanate of Oman.

Maple Syrup Urine Disease (MSUD) is a rare autosomal recessive disorder characterized by deficiency of branched-chain keto acid dehydrogenase complex, which is required to metabolize the three branched chain amino acids (BCAAs), leucine, isoleucine and valine. This metabolic dysfunction results in progressive encephalopathy manifesting with lethargy, vomiting, posturing and abnormal movements during the neonatal period in the classic form of the disease. If untreated, progressive brain damage causes coma, seizures and death usually within a few weeks. Read More

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September 2021

Two Novel Heterozygous Mutations in Association With D-Bifunctional Protein Deficiency: A Case Report and Literature Review.

Front Pediatr 2021 23;9:679597. Epub 2021 Jul 23.

Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

D-Bifunctional protein deficiency (D-BPD) is an autosomal recessive disorder caused by peroxisomal β-oxidation defects. According to the different activities of 2-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase protein units, D-bifunctional protein defects can be divided into four types. The typical symptoms include hypotonia and seizures. Read More

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Evaluation of Seizure Risk in Infants After Cardiopulmonary Bypass in the Absence of Deep Hypothermic Cardiac Arrest.

Neurocrit Care 2022 02 28;36(1):30-38. Epub 2021 Jul 28.

Division of Child Neurology, Lucile Packard Children's Hospital at Stanford University, Dr Levy 750 Welch Road Suite 317, Palo Alto, CA, USA.

Background: Guidelines recommend evaluation for electrographic seizures in neonates and children at risk, including after cardiopulmonary bypass (CPB). Although initial research using screening electroencephalograms (EEGs) in infants after CPB found a 21% seizure incidence, more recent work reports seizure incidences ranging 3-12%. Deep hypothermic cardiac arrest was associated with increased seizure risk in prior reports but is uncommon at our institution and less widely used in contemporary practice. Read More

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February 2022

Early-life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study.

Epilepsia 2021 08 2;62(8):1871-1882. Epub 2021 Jul 2.

Department of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.

Objective: We aimed to evaluate early-life epilepsy incidence, seizure types, severity, risk factors, and treatments among survivors of acute neonatal seizures.

Methods: Neonates with acute symptomatic seizures born 7/2015-3/2018 were prospectively enrolled at nine Neonatal Seizure Registry sites. One-hour EEG was recorded at age three months. Read More

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