1,946 results match your criteria Abnormal Pap Smear


Incidental Serous Tubal Intraepithelial Carcinoma that Developed into Primary Peritoneal Serous Carcinoma in a Patient without BRCA Mutation.

Am J Case Rep 2020 Feb 8;21:e921146. Epub 2020 Feb 8.

Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, South Korea.

BACKGROUND Serous tubal intraepithelial carcinoma (STIC) is proposed as the precursor of ovarian, tubal, and peritoneal high-grade serous carcinoma, but the clinical significance remains unclear, especially in the normal population. We report a rare case of STIC in a patient undergoing non-prophylactic surgery who developed PPSC without a strong family history or BRCA mutations. CASE REPORT A 62-year-old woman presented with an abnormal pap smear (ASC-H). Read More

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http://dx.doi.org/10.12659/AJCR.921146DOI Listing
February 2020

Dominican Provider Practices for Cervical Cancer Screening in Santo Domingo and Monte Plata Provinces.

J Cancer Educ 2020 Jan 17. Epub 2020 Jan 17.

New York University College of Global Public Health, 715 Broadway, Rm 1011, New York, NY, 10003, USA.

Cervical cancer is the second leading cause of cancer death for women in the Dominican Republic. Pap smear screening in the Dominican Republic has not achieved adequate reduction in cervical cancer mortality. The purpose of this study was to examine Dominican provider practices for cervical cancer screening and the use of national or international screening guidelines. Read More

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http://dx.doi.org/10.1007/s13187-020-01690-9DOI Listing
January 2020

Automated Pap Smear Cervical Cancer Screening Using Deep Learning.

Conf Proc IEEE Eng Med Biol Soc 2019 Jul;2019:7044-7048

This study aims to apply Mask Regional Convolutional Neural Network (Mask R-CNN) to cervical cancer screening using pap smear histological slides. Based on our current literature review, this is the first attempt of using Mask R-CNN to detect and analyze the nucleus of the cervical cell, screening for normal and abnormal nuclear features. The data set were liquid-based histological slides obtained from Thammasat University (TU) Hospital. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856369DOI Listing

Human papillomavirus (HPV) subtypes and their relationships with cervical smear results in cervical cancer screening: a community-based study from the central Anatolia region of Turkey.

Int J Clin Exp Pathol 2019 1;12(4):1391-1398. Epub 2019 Apr 1.

MSc, Medical Education and Informatics, Necmettin Erbakan University Medical School Konya, Turkey.

Objective: Cervical cancer can be diagnosed early by cancer screening programs. The aim of this study was to evaluate the cervical smear test results of healthy women.

Methods: We enrolled 94,848 healthy women from 30-65 years of age in whom both HPV typing and a cervical smear test was performed between 2014 and 2017. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947064PMC

Role Of Papanicolaou Smear In Mapping Out Cervical Epithelial Morphology In Women With Infertility: Modified Bethesda Classification.

J Ayub Med Coll Abbottabad 2019 Oct-Dec;31(4):558-562

Institute of Basic Medical sciences, KMU, Peshawar, Pakistan.

Background: Papinocolaou smear (PAP) smear has a specificity of 98% in detecting early changes in cervical epithelium in women above 21 years, thus its avocation as a screening tool for cervical cancers worldwide. In Pakistan with a lack of awareness in our population as well as socioeconomic conditions there is no such screening program. Infertility on the other hand affects 22% of women in Pakistan and thus one of the most common cause of physician visits. Read More

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January 2020

A prospective study of treatments for cervical intraepithelial neoplasia and fecundability.

Am J Obstet Gynecol 2019 Dec 28. Epub 2019 Dec 28.

Department of Epidemiology, Boston University School of Public Health, Boston, MA.

Background: Treatments for cervical intraepithelial neoplasia remove precancerous cells from the cervix by excising or ablating the transformation zone. Most studies show no association between cervical intraepithelial neoplasia treatments and fertility outcomes. However, only 2 studies have examined time to pregnancy, both using retrospective study designs, with 1 study showing no association and the other showing a 2-fold increased risk of infertility (time to pregnancy >12 months) following excisional or ablative treatment. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.12.017DOI Listing
December 2019

The Cost-Effectiveness Analysis of Cervical Cancer Screening Using a Systematic Invitation System in Lithuania.

Int J Environ Res Public Health 2019 12 11;16(24). Epub 2019 Dec 11.

Department of Preventive Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, 47181 Kaunas, Lithuania.

In Lithuania, cytological screening of cervical cancer (CC) is largely opportunistic. Absence of standardized systematic invitation practice might be the reason for low participation rates. The study aimed to assess the cost-effectiveness of systematic invitation approach in CC screening programme from the perspective of a healthcare provider. Read More

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http://dx.doi.org/10.3390/ijerph16245035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950560PMC
December 2019

Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy.

Int J Environ Res Public Health 2019 12 9;16(24). Epub 2019 Dec 9.

Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.

Sexually transmitted infections (STIs) represent a major cause of morbidity in women and men worldwide. Human Papillomavirus (HPV) infections are among the most prevalent STIs and persistent infections with high-risk HPV (hrHPV) genotypes can cause cervical dysplasia and invasive cervical cancer. The association of other STIs with HPV cervical infection and/or dysplasia has however not yet been fully elucidated. Read More

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http://dx.doi.org/10.3390/ijerph16245000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950209PMC
December 2019

Longitudinal assessment of abnormal Papanicolaou test rates among women with HIV.

AIDS 2020 Jan;34(1):73-80

Albert Einstein College of Medicine, Bronx.

Objective: To describe longitudinal changes in the prevalence of abnormal Papanicolau testing among women living with HIV.

Design: Prospective cohort study with sequential enrollment subcohorts.

Methods: Four waves of enrollment occurred in the Women's Interagency HIV Study, the US women's HIV cohort (1994-1995, 2001-2002, 2011-2012, 2013-2015). Read More

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http://dx.doi.org/10.1097/QAD.0000000000002388DOI Listing
January 2020
5.554 Impact Factor

Circulating ensembles of tumor-associated cells: A redoubtable new systemic hallmark of cancer.

Int J Cancer 2019 Nov 30. Epub 2019 Nov 30.

Department of Research and Innovations, Datar Cancer Genetics Limited, Nasik, India.

Circulating ensembles of tumor-associated cells (C-ETACs) which comprise tumor emboli, immune cells and fibroblasts pose well-recognized risks of thrombosis and aggressive metastasis. However, the detection, prevalence and characterization of C-ETACs have been impaired due to methodological difficulties. Our findings show extensive pan-cancer prevalence of C-ETACs on a hitherto unreported scale in cancer patients and virtual undetectability in asymptomatic individuals. Read More

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http://dx.doi.org/10.1002/ijc.32815DOI Listing
November 2019

Combined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scrapings.

Clin Epigenetics 2019 Nov 28;11(1):170. Epub 2019 Nov 28.

Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, New Taipei, Taiwan.

Background: Endometrial cancer is a common gynecologic cancer. Noninvasive molecular biomarkers for triage of high-risk patients for invasive procedures are needed. Based on the success of cytological Pap smear screening, cervical scrapings are a good source of DNA for molecular testing. Read More

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http://dx.doi.org/10.1186/s13148-019-0765-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883641PMC
November 2019

A case of endometrial glassy cell carcinoma: a rare entity which necessitates of better understanding.

Obstet Gynecol Sci 2019 Nov 28;62(6):478-482. Epub 2019 Oct 28.

Department of Obstetrics and Gynecology, Bolognini Hospital, Seriate, Italy.

Endometrial glassy cell carcinoma (EGCC) is a rare neoplasm, accounting for 0.5% of the carcinomas in the endometrium, composed of cells with granular eosinophilic or amphophilic cytoplasm, giving it a ground glass appearance. Till date, only 14 cases of this carcinoma have been reported. Read More

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http://dx.doi.org/10.5468/ogs.2019.62.6.478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856485PMC
November 2019

Deep Convolution Neural Network for Malignancy Detection and Classification in Microscopic Uterine Cervix Cell Images.

Asian Pac J Cancer Prev 2019 Nov 1;20(11):3447-3456. Epub 2019 Nov 1.

Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Educaton, Udupi, Karnataka, India.

Objective: Automated Pap smear cervical screening is one of the most effective imaging based cancer detection
tools used for categorizing cervical cell images as normal and abnormal. Traditional classification methods depend on
hand-engineered features and show limitations in large, diverse datasets. Effective feature extraction requires an efficient
image preprocessing and segmentation, which remains prominent challenge in the field of Pathology. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.11.3447DOI Listing
November 2019

Cervical intraepithelial neoplasia during pregnancy.

Indian J Cancer 2019 Nov 18. Epub 2019 Nov 18.

Department of Obstetrics and Gynecology, Medical University of Warsaw, Pl. Starynkiewicza 1/3, Warszawa, Poland.

Objectives: The aim was to analyze the unaffected course of cervical intraepithelial neoplasia (CIN) in pregnant women and to compare the rates of lesion persistence, progression, and regression.

Materials And Methods: Patients with abnormal cytology included in the study underwent colposcopy, followed by a biopsy of the cervix. At the end of the postpartum period, all patients underwent Pap smear, colposcopy, and endocervical curettage to obtain tissue samples. Read More

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http://dx.doi.org/10.4103/ijc.IJC_403_18DOI Listing
November 2019

Ultrasonic and Histopathological Evaluation to Exclude Premalignant and Malignant Lesions in Perimenopausal and Postmenopausal Women Presenting as Abnormal Uterine Bleeding.

J Obstet Gynaecol India 2019 Oct 21;69(Suppl 2):171-176. Epub 2018 Aug 21.

4Biostatics, IGIMS, Patna, India.

Introduction: Abnormal uterine bleeding may be defined as bleeding pattern that differs in frequency, duration and amount from a pattern observed during a normal menstrual cycle or after menopause.

Aim And Objective: The aim of this study was (1) to identify the different benign, premalignant and malignant conditions as the cause of abnormal uterine bleeding in perimenopausal and postmenopausal women and (2) to find out the different histopathological patterns of endometrium and cervix in these women.

Materials And Methods: This is a prospective study done in gynaecological oncology in 100 cases attending the OPD. Read More

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http://dx.doi.org/10.1007/s13224-018-1166-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801292PMC
October 2019
1 Read

Incidence of abnormal cervical and vaginal cytology among women over age 65 years living with human immunodeficiency virus.

Am J Obstet Gynecol 2019 Oct 31. Epub 2019 Oct 31.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.

Background: Women with human immunodeficiency virus have higher rates of abnormal cervical and vaginal cytology and, subsequently, of cervical and vaginal cancers. Although professional bodies currently advocate for indefinite cytology screening for women living with human immunodeficiency virus, these recommendations are based on expert opinion, not evidence-based. In the general population, women who have never had an abnormal cytology result can cease screening at age 65 years. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.10.011DOI Listing
October 2019
1 Read

Cervical cytology reproducibility and associated clinical and demographic factors.

Diagn Cytopathol 2020 Jan 22;48(1):35-42. Epub 2019 Oct 22.

Department of Biostatistics and Data Science, The University of Texas School of Public Health, Houston, Texas.

Background: Although the Pap test has been the standard screening method for cervical precancer/cancer detection, it has been criticized for having a relatively low sensitivity and a low reproducibility between pathologists. There is limited knowledge about inter-rater agreement and what clinical and demographic factors are associated with disagreements between pathologists reading the same Pap smear.

Methods: This study aimed to assess inter- and intra- rater agreement of the Pap smear in 1619 cytologic slides with biopsy confirmation, using kappa statistics. Read More

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http://dx.doi.org/10.1002/dc.24325DOI Listing
January 2020
1 Read

Association of Abnormal Pap Smear with Occult Cervical Stromal Invasion in Patients with Endometrial Cancer.

Asian Pac J Cancer Prev 2019 09 1;20(9):2847-2850. Epub 2019 Sep 1.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kean, Thailand.

Objective: The purpose of this study was to determine the association between abnormal preoperative Pap smear results and occult cervical stromal invasion in endometrial cancer patients. Methods: Medical records were reviewed of patients with endometrial cancer who had undergone surgical staging at Srinagarind Hospital. Patients with gross cervical involvement, with an unsatisfactory Pap smear, without available Pap smear results, with no cervical intraepithelial lesion/invasive cervical cancer, or who had previously undergone pelvic radiation therapy were excluded. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.9.2847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976850PMC
September 2019
2 Reads

Trends in Uterine Cervical Cancer Screening at Physical Health Checkups for Company Employees in Japan.

J UOEH 2019 ;41(3):327-333

Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.

The consultation rate for uterine cervical cancer screening in Japan is markedly low in comparison with other developed countries. The purpose of this study is to investigate the trends in uterine cervical cancer screening during regular company checkups and to identify potential problems. Questionnaires were sent to occupational health physicians through Sansuiken (Alumni Association of the University of Occupational and Environmental Health, Japan). Read More

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http://dx.doi.org/10.7888/juoeh.41.327DOI Listing
January 2019
1 Read

Cytological changes in oral mucosa induced by smokeless tobacco.

Tob Induc Dis 2019 28;17:46. Epub 2019 May 28.

Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia.

Introduction: This study investigated the cellular changes in the mouth of smokeless tobacco (shamma) users among Saudi citizens from the Najran region.

Methods: Healthy 61 shamma users and healthy 61 non-users participated in this study after informed consent. A mouth swap was taken from each study subject and investigated for cellular changes using a Papanicolaou stain. Read More

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http://dx.doi.org/10.18332/tid/109544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662786PMC
May 2019
1 Read

Cervical Cancer Prevention in Racially Disparate Rural Populations.

Medicines (Basel) 2019 Sep 4;6(3). Epub 2019 Sep 4.

Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.

Undergoing a timely Pap smear, high-risk human papilloma virus (HPV)- and colposcopy-based testing can reduce HPV-associated cervical cancer (CC) development in women. However, in rural areas, women and minorities without insurance do not undergo periodic assessment and remain at greater risk of HPV infection and CC. In this study, 173 women from rural East Texas with various ethnic backgrounds were examined thorough HPV/Pap-based testing and colposcopic assessment. Read More

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http://dx.doi.org/10.3390/medicines6030093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789706PMC
September 2019
7 Reads

Women's experiences after abnormal Pap smear results: a qualitative study.

J Psychosom Obstet Gynaecol 2020 Mar 27;41(1):22-29. Epub 2019 Aug 27.

Midwifery Department, Health Science Faculty, Manisa Celal Bayar University, Manisa, Turkey.

Abnormal Pap smear result means there have been cell changes on the cervix but are not cancer. Women with abnormal test result may be affected from this situation. What do women with abnormal Pap smear results experience from a biopsychosocial perspective? This study aimed to explore the experiences of women with abnormal Pap smear results according to the biopsychosocial model. Read More

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http://dx.doi.org/10.1080/0167482X.2019.1657090DOI Listing
March 2020
1 Read

A study of association between cervical cytology and period of co-habitation with husbands in the wives of serving soldiers.

Med J Armed Forces India 2019 Jul 4;75(3):293-296. Epub 2018 Jul 4.

Medical Officer, 4003 Field Hospital, C/o 99 APO, India.

Background: The wives of serving soldiers constitute a special demographic cohort, as they spend variable amount of time in co-habitation with their husbands. The present study aims to find if any independent association, adjusted for age, exists between the time spent living together with the husband and findings on cervical smear.

Methods: Over a period of one year, cervical smears were taken from subjects at two different hospitals. Read More

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http://dx.doi.org/10.1016/j.mjafi.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676328PMC

Burden and genotype distribution of high-risk Human Papillomavirus infection and cervical cytology abnormalities at selected obstetrics and gynecology clinics of Addis Ababa, Ethiopia.

BMC Cancer 2019 Aug 5;19(1):768. Epub 2019 Aug 5.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Human papillomavirus is recognized as a major cause of cervical cancer. It is estimated that annually, 7,095 women are diagnosed with cervical cancer and 4,732 die from the disease in Ethiopia. Understanding that the screening practice is very poor and the coverage is very limited, this disease burden is one of the major public health agendas in Ethiopia. Read More

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http://dx.doi.org/10.1186/s12885-019-5953-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683490PMC
August 2019
1 Read

Cervical high-grade squamous intraepithelial lesion on conventional cytology: Cytological patterns, pitfalls, and diagnostic clues.

Diagn Cytopathol 2019 Dec 5;47(12):1267-1276. Epub 2019 Aug 5.

Division of Cytopathology, ICMR-National Institute of Cancer Prevention and Research, Noida, India.

Background: Conventional cervical cytology, which has a relatively low sensitivity in diagnosing high-grade lesions as compared to liquid-based cytology, is still being practiced in low resource settings. This study aimed at elucidating various cytomorphological patterns, pitfalls, and subtle clues to high-grade squamous intraepithelial lesion (HSIL) diagnosis on conventional cervical cytology through cytologic-histologic correlation.

Methods: Cervical biopsies reported as CIN2/3 were correlated with their corresponding Pap smears over a 10-year period to determine the frequency of undercalls. Read More

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http://dx.doi.org/10.1002/dc.24293DOI Listing
December 2019
3 Reads

Human Papillomavirus Genotyping among Different Cervical Smears in Duhok/Iraq.

Asian Pac J Cancer Prev 2019 07 1;20(7):2059-2064. Epub 2019 Jul 1.

Department of Microbiology, College of Medicine, University of Duhok, Iraq. Email:

Background/Objective: Cervical cancer ranks the second among the most common gynecologic cancers. This study was established to determine the distribution of cervical HPV genotypes among different Pap readings in Duhok/Iraq. Methods: Between January and September-2016, HPV-DNA was tested in 64 women. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.7.2059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745234PMC

Medical diligence uncovers fallopian tube cancer after abnormal Pap test.

BMJ Case Rep 2019 Jul 24;12(7). Epub 2019 Jul 24.

Obstetrics, Gynecology, and Women's Health, Saint Louis University, St Louis, Missouri, USA.

The fallopian tube has received attention as an origin of high-grade pelvic malignancies. This is a case of bilateral fallopian tube cancer discovered after an abnormal Pap test. A 62-year-old woman with a history of one term delivery had atypical glandular cells on a Pap test. Read More

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http://dx.doi.org/10.1136/bcr-2019-229762DOI Listing
July 2019
3 Reads

Comparable expression of miR-let-7b, miR-21, miR-182, miR-145, and p53 in serum and cervical cells: Diagnostic implications for early detection of cervical lesions.

Int J Health Sci (Qassim) 2019 Jul-Aug;13(4):29-38

Department of Family Medicine, State Hospital Ijaiye, Abeokuta, Ogun State, Nigeria.

Objective: The high mortality associated with cervical cancer is due to low uptake of Pap smear test, lack of early diagnostic biomarkers and less-invasive approach, and late presentation of the disease. This study evaluated the expression of hsa-miR-let-7b, hsa-miR-21, hsa-miR-125b, hsa-miR-143, hsa-miR-145, hsa-miR-146a, hsa-miR-155, hsa-miR-182, hsa-miR-200c, and p53 in serum and cervix in relation to classes of Pap smear, in a bid to identify a serum panel for early diagnosis of cervical lesions.

Methodology: This study included 329 women; 159 healthy women (HW), 46 cervicitis, 46 atypical squamous cells of undetermined significance (ASCUS), 40 low-grade squamous cell intraepithelial lesion (LSIL), 28 high-grade squamous cell intraepithelial lesion (HSIL), and 10 squamous cell carcinoma (SCC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619463PMC
July 2019
3 Reads

Searching for an ideal cervical cancer screening model to reduce false-negative errors in a country with high prevalence of cervical cancer.

J Obstet Gynaecol 2020 Feb 25;40(2):240-246. Epub 2019 Jul 25.

Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.

The purpose of this study was to develop an ideal cervical cancer screening model to reduce false-negative errors in Korea where there is a high prevalence of cervical cancer. We conducted a cross-sectional study including 33,531 women who underwent routine cervical cancer screening in Korea. Colposcopic examinations were performed after abnormal results on their screening tests. Read More

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http://dx.doi.org/10.1080/01443615.2019.1621813DOI Listing
February 2020
2 Reads
0.604 Impact Factor

Age-related acceptability of vaginal self-sampling in cervical cancer screening at two university hospitals: a pilot cross-sectional study.

BMC Public Health 2019 Jul 18;19(1):963. Epub 2019 Jul 18.

Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: To determine whether age is a barrier against acceptability of cervicovaginal self-sampling in screening for cervical cancer at two gynecology outpatient clinics.

Methods: This is a cross-sectional study involving 116 women over 21 years of age with an abnormal Pap smear. Clinical and laboratorial data were recorded in electronic files. Read More

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http://dx.doi.org/10.1186/s12889-019-7292-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637504PMC
July 2019
2 Reads

Recurrence of genitals warts in pre-HPV vaccine era after laser treatment.

Arch Gynecol Obstet 2019 Sep 8;300(3):661-668. Epub 2019 Jul 8.

Department of Obstetrics and Gynecology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Purpose: Human papillomavirus (HPV) can cause condylomata acuminata, also known as genital warts. Our aim was to evaluate the long-term recurrence of genital warts after primary carbon dioxide laser treatment before the introduction of the vaccination against HPV.

Methods: Recurrence rate and localization of genital warts were analysed in a retrospective study in 1798 women presenting with a new diagnosis of genital warts from 1992 to 2009 at a University hospital and had received laser treatment. Read More

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http://dx.doi.org/10.1007/s00404-019-05242-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694085PMC
September 2019
13 Reads

Anal Intraepithelial Neoplasia Screening With Anal Pap Tests: Follow-up and Corresponding Histology.

J Surg Res 2019 12 5;244:117-121. Epub 2019 Jul 5.

Division of Colon and Rectal Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Department of Surgery, W. S. Middleton Memorial Veteran's Hospital, Madison, Wisconsin.

Background: Anal cytology is used as a screening tool in the detection of precancerous anal squamous lesions. Follow-up clinical examination after abnormal anal cytology is recommended. The objective of this study was to determine how often abnormal cytology was followed by a clinical examination at our institution and how often cytology predicted histologic outcome. Read More

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http://dx.doi.org/10.1016/j.jss.2019.06.029DOI Listing
December 2019
6 Reads

Factors associated with high-risk human papillomavirus infection and high-grade cervical neoplasia: A population-based study in Paraguay.

PLoS One 2019 27;14(6):e0218016. Epub 2019 Jun 27.

Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción (IICS-UNA), San Lorenzo, Paraguay.

Background: Cervical cancer (CC) is one of the leading causes of cancer mortality among women from Paraguay, with high incidence and mortality rates (31.2 and 16 per 100 000 women, respectively). Although the risk factors associated with high-risk human papillomavirus (hrHPV) infection and preneoplastic cervical lesions are widely studied, population-based characteristics of particular settings may influence the feasibility of HPV-based CC screening implementation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218016PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597051PMC
February 2020
12 Reads

The Incidence and Clinical Significance of Atypical Glandular Cells of Undetermined Significance on Cervical Pap Smears.

Gulf J Oncolog 2019 May;1(30):52-56

Department of Obstetrics and Gynecology, King Hussein Medical Centre, Amman, Jordan.

Objective: To determine the incidence and the association between atypical glandular cells (AGC) reported on cervical pap smears and the underlying malignant and pre-malignant genital tract pathology.

Methods: A retrospective study was performed on the files of women who were had attended our colposcopy clinic at King Hussein Medical Centre (KHMC), between April 2014 and April 2018. Out of 8483 cervical pap smears reviewed, 68 patients have smears reported to be atypical glandular cells of undetermined significance (AGUS). Read More

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May 2019
11 Reads

Correlation between integration of high-risk HPV genome into human DNA detected by molecular combing and the severity of cervical lesions: first results of the EXPL-HPV-002 study.

Ceska Gynekol 2019 ;84(2):84-92

Objectives: The aim of the EXPL-HPV-002 study is to evaluate the integration of 14 high-risk HPV as a biomarker of the severity and the progression of cervical lesions. Such a „triage biomarker“ would help to reduce the number of unnecessary colposcopies, to avoid over-treatment of lesions that spontaneously regress and to better target the lesions requiring treatment.

Design: EXPL-HPV-002 is a prospective, open-label, single arm, GCP study conducted at 2 clinical sites in the Czech Republic. Read More

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July 2019
9 Reads

Cervical Cancer, Different Treatments and Importance of Bile Acids as Therapeutic Agents in This Disease.

Front Pharmacol 2019 4;10:484. Epub 2019 Jun 4.

Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

Cervical cancer can be cured, because it has a long preinvasive period. Early diagnosis and treatment of cervical cancer at women are crucial for reducing of rate mortality. Today, there are many methods for detecting premalignant lesions and one of them is a conventional Papanicolaou test. Read More

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http://dx.doi.org/10.3389/fphar.2019.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558109PMC
June 2019
10 Reads

Pharmacokinetics of vaginal progesterone in pregnancy.

Am J Obstet Gynecol 2019 09 15;221(3):263.e1-263.e7. Epub 2019 Jun 15.

Division of Maternal Fetal Medicine, Magee Womens Hospital, Pittsburgh, PA.

Background: Characterization of pharmacokinetics is lacking for vaginal progesterone in pregnancy. Dosing of vaginal progesterone for preterm birth prevention has been empirical. Owing to pregnancy-related changes in vaginal and uterine blood flow, hepatic metabolism, renal clearance, and endogenously elevated serum progesterone, studies outside of pregnancy may not be applicable. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732017PMC
September 2019
7 Reads

Reliability and validity of the Center for Epidemiologic Studies Depression (CES-D) scale in Serbian women with abnormal Papanicolaou smear results.

Int J Gynecol Cancer 2019 07 14;29(6):996-1002. Epub 2019 Jun 14.

Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Objectives: Cervical cancer ranks as the second most frequent cancer among women in Serbia. Organized screening for detection of cervical cancer was introduced in Serbia in 2013 and provided free of charge in all state health facilities. Studies have shown that depression frequently follows the notification of abnormal findings on the Papanicolaou (Pap) screening test. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000219DOI Listing
July 2019
5 Reads

Psychological distress among women with abnormal pap smear results in Serbia: Validity and reliability of the Cervical Dysplasia Distress Questionnaire.

PLoS One 2019 12;14(6):e0218070. Epub 2019 Jun 12.

Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Receiving report of an abnormal finding from a Pap screening test in women often leads to psychological distress.

Objectives: The purpose of this study was to assess the reliability and validity of the Cervical Dysplasia Distress Questionnaire (CDDQ) among women in Serbia.

Methods: In 2017, we conducted a cross-sectional study involving 154 consecutive women attending cervical cancer screening who had received abnormal Pap smear results. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561558PMC
February 2020
9 Reads

Role of ThinPrep liquid-based cytology in evaluation of the endocervical canal in patients with abnormal cervical screening.

J Am Soc Cytopathol 2019 Sep - Oct;8(5):278-283. Epub 2019 May 17.

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address:

Introduction: Endocervical sampling is frequently used as an adjunct to colposcopy. Few studies address the role of endocervical brushing (ECB) with liquid-based cytology (LBC) for evaluation of the endocervical canal. We assessed the roles of ThinPrep (TP) LBC of ECB specimens and cell blocks (CBs). Read More

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http://dx.doi.org/10.1016/j.jasc.2019.05.001DOI Listing
May 2019
5 Reads

Abnormal Pap smear frequency and comparison of repeat cytological follow-up with colposcopy during patient management: the importance of pathologist's guidance in the management.

North Clin Istanb 2019 14;6(1):69-74. Epub 2018 Aug 14.

Department of Pathology, New York Medical College, Valhalla, New York, NY, USA.

Objective: Cervical cancer contributes to a significant global health burden with room for improvement of primary prevention methods. This study aimed to determine the prevalence of Turkish women with abnormal cytology and their management by comparing results from repeat cytological analysis with close follow-up and colposcopy.

Methods: A retrospective evaluation of 8738 women who underwent Pap smears at a single institution during 2011 was performed. Read More

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http://dx.doi.org/10.14744/nci.2018.93270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526981PMC
August 2018
4 Reads

Atypical cytological changes mimicking SIL of the uterine cervix in allogenic hematopoietic stem cell transplantation recipients treated with busulfan.

Cancer Cytopathol 2019 May 30. Epub 2019 May 30.

Long-Term Follow-Up Unit and Hematopoietic Stem Cell Transplantation Unit, Hematology Department, Institute of Hematology and Oncology, August Pi i Sunyer Institute for Biomedical Investigations, University of Barcelona, Barcelona, Spain.

Background: Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft-versus-host disease prophylaxis is associated with human papillomavirus (HPV) persistence and, consequently, with an increased risk of cervical cancer (CC) and squamous intraepithelial lesions (SILs)-the precursors of CC. A gynecological check-up that includes CC screening is recommended in these patients. Read More

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http://dx.doi.org/10.1002/cncy.22148DOI Listing
May 2019
6 Reads

[Prevalence and genotype distribution of human papillomavirus in patients attending to gynecology polyclinics].

Mikrobiyol Bul 2019 Apr;53(2):170-178

Pamukkale University Faculty of Medicine, Department of Obstetrics and Gynecology, Denizli, Turkey.

Human papillomavirus (HPV) infection is the most significant risk factor of the development of cervical cancer. The distribution of HPV prevalence and genotype varies widely between regions. In this study, it was aimed to investigate the prevalence and genotype distribution of HPV, retrospectively. Read More

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http://dx.doi.org/10.5578/mb.67765DOI Listing
April 2019
28 Reads

Histopathological Patterns and Characteristics of Abnormal Cervical Smear in Madinah Region of Saudi Arabia

Asian Pac J Cancer Prev 2019 May 25;20(5):1303-1307. Epub 2019 May 25.

Department of Pathology, Maternity and Children Hospital, Alhezam Road, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia.

Cervical cancer is a major public health problem that continues to be one of the leading female genital cancers worldwide. In the kingdom of Saudi Arabia (KSA), cervical cancer ranks the fifteenth most frequent cancer among females. This study is the first published research study addressing the screening of cervical cancer in Madinah region of KSA. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.5.1303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857873PMC
May 2019
5 Reads

Comparison of the diagnostic value of the visual inspection with acetic acid (VIA) and Pap smear in cervical cancer screening.

Taiwan J Obstet Gynecol 2019 May;58(3):345-348

Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran.

Objective: This study aimed to compare the diagnostic value of VIA with Pap smear in screening for cervical cancer.

Materials And Methods: In this cross-sectional study, 440 women who had eligibility criteria, in Kashan city were assessed. All women underwent Pap smear test and then a visual inspection with acetic acid and colposcopy-biopsy (Gold Standard). Read More

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http://dx.doi.org/10.1016/j.tjog.2019.03.010DOI Listing
May 2019
6 Reads

A reproductive justice approach to understanding women's experiences with HPV and cervical cancer prevention.

Soc Sci Med 2019 07 10;232:289-297. Epub 2019 May 10.

Arnold School of Public Health, University of South Carolina, USA.

Cervical cancer is a preventable disease. HPV infection has been linked to more than 90% of cervical cancers. A vaccine to prevent the acquisition of HPV has been available since 2006. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.05.010DOI Listing
July 2019
7 Reads

Postcoital bleeding is a predictor for cervical dysplasia.

PLoS One 2019 23;14(5):e0217396. Epub 2019 May 23.

Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.

Background: Postcoital bleeding (PCB) is a common gynecological symptom that may cause concern among both patients and physicians. Current literature is inconclusive regarding management recommendations.

Objective: To identify risk-factors for dysplasia/cancer among patients presenting post-coital bleeding (PCB). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217396PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532898PMC
January 2020
15 Reads

Evaluation of Abnormal Cervix with Visual Inspection under Acetic Acid and Colposcopy.

J Nepal Health Res Counc 2019 Apr 28;17(1):76-79. Epub 2019 Apr 28.

Department of Obstetrics and Gynaecology, Kathmandu Model Hospital, Kathmandu, Nepal.

Background: Cervical cancer is a major public health problem especially in developing countries. It can be prevented through implementation of routine screening program. There are different screening methods but their efficacy are still questionable. Read More

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http://dx.doi.org/10.33314/jnhrc.1809DOI Listing
April 2019
16 Reads

Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ.

J Am Soc Cytopathol 2019 May - Jun;8(3):141-148. Epub 2018 Dec 31.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Introduction: Recognition of adenocarcinoma in situ (AIS) in cervical cytology is challenging.

Materials And Methods: We calculated the sensitivity and accuracy of Papanicolaou (Pap) tests obtained within 1 year of a histologic diagnosis of AIS from 2007 to 2016. We also correlated it with the coexistence of squamous lesions, calculated the interobserver agreement, and compared these measures with those of endocervical adenocarcinoma (ECCA). Read More

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http://dx.doi.org/10.1016/j.jasc.2018.12.004DOI Listing
December 2018
1 Read

Prevalence of abnormal cervical cancer screening outcomes among screening-compliant women in the United States.

Am J Obstet Gynecol 2019 07 9;221(1):75-77. Epub 2019 May 9.

Department of Epidemiology, Division of Cancer Prevention and Population Sciences, University of Texas M. D. Anderson Cancer Center, 1400 Pressler Drive, FCT4.6002, Houston, TX 77030; Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, 1400 Pressler Drive, FCT4.6002, Houston, TX 77030; Division of Cancer Prevention and Population Sciences, University of Texas M. D. Anderson Cancer Center, 1400 Pressler Drive, FCT4.6002, Houston, TX 77030. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193057
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http://dx.doi.org/10.1016/j.ajog.2019.04.014DOI Listing
July 2019
10 Reads