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Chirurgia (Bucur) 2020 May-Jun;115(3):404-409

The GIST tumors are very rare entities ( 1% of all tumors). They originate in the Cajal interstitial cells, which are part of the autonomic nervous system of the intestine. Their most common location is the stomach, followed by the small intestine. Read More

Ter Arkh 2019 May 15;91(5):49-53. Epub 2019 May 15.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University).

Aim: To present clinical and laboratory characteristics of various forms of idiopatic lobular panniculitis (ILP) in modern rheumatology practice.

Materials And Methods: The study included 67 people (58 women and 9 men aged 20 to 76) with the referral diagnosis of "Erythema nodosa? Undifferentiated panniculitis?" in 76.2% of cases with a median disease duration of 78. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20874

Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province.

Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20854

Department of Pathology, Third Central Hospital of Tianjin, Tianjin Third Central Hospital affiliated to Nankai University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases.

Introduction: Although primary hepatic neuroendocrine carcinomas, whose prognostic mechanisms remain unclear, are rare, coexistence of neuroendocrine carcinomas and other tumors is rarer. In this report, we describe a unique case of coexistence between primary hepatic neuroendocrine carcinoma and a distal cholangiocarcinoma in the pancreas.

Patient Concerns: A 64-year-old woman with a history of diabetes, but none of hepatitis, was admitted to hospital because of intermittent epigastric distension and pain discomfort for more than 1 month aggravated 1 day. Read More

Rev Invest Clin 2020 ;72(3):165-177

Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic.

Objective: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). Read More

Medicine (Baltimore) 2020 Jun;99(25):e20580

Department of Vascular Surgery, The Clinical Medical School of Yangzhou University, Yangzhou.

Introduction: Protein-losing enteropathy and spontaneous isolated superior mesenteric artery dissection are both rare clinically. Protein-losing enteropathy due to superior mesenteric artery dissection is extremely rare.

Patient Concerns: A 46-year-old male with acute abdominal pain and hematochezia was diagnosed with a complete occlusion of the superior mesenteric artery because of dissection. Read More

Geriatr Psychol Neuropsychiatr Vieil 2020 Jun;18(2):135-140

Département de gériatrie et Centre Mémoire Ressources Recherche, Centre de recherche sur l'autonomie et la longévité, Centre hospitalier universitaire, Angers, France, UPRES EA 4638, Université d'Angers, Angers, France, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada.

The COVID-19 pandemic is particularly severe in older adults. Our objective was to identify, from international literature, the most common symptoms met in older adults infected with the SARS-CoV-2 virus. This systematic review of the literature was conducted using MEDLINE from December 1, 2019 to April 13, 2020. Read More

Medicine (Baltimore) 2020 Jun;99(24):e20627

Department of Obstetrics and Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

The aim of our study was to compare the clinical and surgical characteristics of pregnant and nonpregnant women with surgically verified ovarian torsion, as well as the differences among 3 trimesters during pregnancy.We conducted a retrospective study of patients diagnosed with surgically proven ovarian torsion in our hospital from January 2012 to June 2018. The clinical characteristics, surgical procedure, pathologic outcomes, and trimesters of pregnancy were analyzed. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):550-555

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathological features of pulmonary epithelioid hemangioendothelioma (PEHE). Eighteen cases of PEHE were collected from August 2011 to December 2018 at the First Affiliated Hospital of Zhengzhou University. All cases were retrospectively studied by hematoxylin and eosin staining and immunohistochemistry (IHC). Read More

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):426-431

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. In our study, 355 patients pathologically diagnosed as GEP-NENs were identified from April 2006 to November 2017 in the Fourth Hospital of Hebei Medical University. The biological behavior, pathological characteristics and prognosis were analyzed retrospectively. Read More

Medicine (Baltimore) 2020 May;99(22):e19956

Division of Respirology.

Rationale: Malignant peritoneal mesothelioma is a rare tumor with a poor prognosis and has no recommended therapy after first-line pemetrexed and platinum-based chemotherapy. Moreover, effects of immune checkpoint inhibitors on peritoneal mesothelioma remains to be elucidated. We herein report the case of a 75-year-old man with peritoneal mesothelioma treated with cisplatin plus pemetrexed and subsequent nivolumab. Read More

Medicine (Baltimore) 2020 May;99(21):e19887

Division of Gastroenterology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Introduction: Spontaneous bacterial peritonitis (SBP) is a fatal infection in patients. It often happens in patients with cirrhosis, cancer or diabetes, and is caused mostly by Enterobacteriaceae. Here we report a rare case of SBP caused by Campylobacter Coli (C coli) infection, which was identified promptly by the matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and received adequate therapy sooner after. Read More

JAMA 2020 05;323(20):2029-2038

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore.

Importance: Abdominal aortic aneurysms affect more than 3% of US older adults.

Objective: To test whether doxycycline reduces the growth of abdominal aortic aneurysm over 2 years as measured by maximum transverse diameter.

Design, Setting, And Participants: Parallel, 2-group, randomized clinical trial that was conducted at 22 US clinical centers between May 2013 and January 2017, and enrolled patients 50 years or older with small (3. Read More

Clin Nucl Med 2020 Jul;45(7):e305-e306

From the Departments of Nuclear Medicine.

A 52-year-old woman with no medical history was admitted on March 18, 2020, presenting since 3 days asthenia, abdominal pain, and dry cough but no fever. Adenomegalies, splenomegaly, leukocytosis, and elevated LDH suggested mature lymphoproliferation. Considering the current health context, an RT-PCR testing for COVID-19 (coronavirus disease 2019) was performed and found to be positive. Read More

Medicine (Baltimore) 2020 May;99(20):e20220

Department of Respiratory Medicine.

Rationale: Chilaiditi syndrome is a rare disorder characterized by a broad spectrum of (gastro-intestinal) symptoms caused by interposition of a segment of bowel between the liver and the diaphragm. Most cases present with abdominal symptoms and the morbidity tend to increase with age.

Patient Concerns: Here we present a rare case of Chilaiditi syndrome. Read More

Medicine (Baltimore) 2020 May;99(20):e20062

Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

The aim of this study was to investigate the effect of enhanced recovery after surgery (ERAS) on perioperative outcomes, with an emphasis on patient-reported outcomes (PROs) and functional recovery.We compared the clinical outcomes in a cohort of 275 patients undergoing liver resection before and after the implementation of ERAS. The PROs were preoperatively and postoperatively compared until 14 days after surgery using the MD Anderson Symptom Inventory. Read More

Ann Vasc Surg 2020 Jul 11;66:14-17. Epub 2020 May 11.

Maimonides Medical Center, Division of Vascular and Endovascular Surgery, Brooklyn, NY.

We report a patient who presented with acute abdominal pain during the COVID-19 pandemic. His work-up revealed rupture of a 5.8 cm abdominal aortic aneurysm. Read More

Eur Rev Med Pharmacol Sci 2020 05;24(9):5162-5166

Department of General Surgery, Ospedale Valduce, Como, Italy.

Objective: Over the ongoing pandemic of coronavirus disease 2019 (COVID-19), the demand for critical care beds among medical services has rapidly exceeded its supply. Elective surgery has comprehensively been drastically limited and allocating intensive care beds to emergency cases or to high risk scheduled elective cases has become an even more difficult task. Here we present our experience which could help to handle undelayable surgical procedures during this emergency. Read More

Surg Technol Int 2020 May;36:99-104

Introduction: Laparoscopic inguinal hernia repair has certain advantages over open repair including less pain and earlier return to normal activity. Robotic surgery adds high definition visualization and articulating instruments. This enhanced dexterity can make laparoscopic hernia repair more refined while obtaining a critical view of the myopectineal orifice that should lead to fewer recurrences and complications. Read More

Arq Bras Cir Dig 2020 18;33(1):e1495. Epub 2020 May 18.

Department ofSurgery, Hospital Nossa Senhora das Graças, Curitiba, PR, Brazil.

Background: Median arcuate ligament syndrome(MALS) is a rare condition thatmay cause significant clinical manifestations, including abdominal pain and weight loss. Its diagnosis may be difficult and very often delayed. The laparoscopic approach became the standard treatment of MALS. Read More

Intern Med 2020 15;59(10):1257-1265. Epub 2020 May 15.

Department of General Medicine, Saga University Hospital, Japan.

Objective Acute abdominal pain (AAP) of diverse etiology is a common chief complaint of patients who present to the emergency department (ED). AAP may pose a diagnostic challenge to physicians in training. We aimed to evaluate whether or not resident trainee doctors examine patients presenting with AAP in a Japanese acute-care hospital following Kendall's diagnostic algorithm. Read More

Ulus Travma Acil Cerrahi Derg 2020 Apr;26(3):335-342

Istanbul University, Istanbul School of Medicine, Department of Surgery, Istanbul, Turkey.

COVID-19 is a new disease, based on currently available limited information, older adults and people of any age who have severe underlying medical conditions may be at higher risk for severe illness from COVID-19. People of all age groups are also at risk. Healthcare providers have always been the professionals most exposed to the risk of contracting to any kind of infection due to the nature of their profession. Read More

Ned Tijdschr Geneeskd 2020 Apr 2;164. Epub 2020 Apr 2.

Bernhoven, afd. Interne Geneeskunde, Uden.

Objective: To describe disease presentation and clinical characteristics of patients with COVID-19 presenting to the Emergency Department (ED) of Bernhoven hospital in Uden, the Netherlands.

Design: Prospective, descriptive study.

Method: The registry focused on atypical symptoms and co-infections. Read More

Am Surg 2020 Apr;86(4):324-333

From the *Saint Agnes Hospital, Baltimore, Maryland.

Overutilization of healthcare resources is a threat to long-term healthcare sustainability and patient outcomes. CT is a costly but efficient means of assessing abdominal pain; however, 97 per cent of ED physicians acknowledge its overutilization. This study sought to understand factors that influence ED providers' decision regarding CT use in the evaluation of abdominal pain. Read More

Pancreatology 2020 Jun 5;20(4):665-667. Epub 2020 May 5.

Pancreatitis Centre East, Gastrounit, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background/objectives: Abdominal pain is one of the known symptoms associated with coronavirus disease 2019. Little is known about the development of acute pancreatitis as a complication of severe acute respiratory syndrome coronavirus 2 infection. This case report describes the presentation of acute pancreatitis in two of three family members with severe COVID-19 infection. Read More

Medicine (Baltimore) 2020 May;99(19):e20098

Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei Campus.

Bacillus coagulans (PROBACI) bacteria have been examined for efficacy against infectious or inflammatory bowel diseases. The aim of this observational and cross-sectional study was to evaluate the effects of PROBACI against various functional bowel symptoms.Thirty-eight enrolled patients (36. Read More

Medicine (Baltimore) 2020 May;99(19):e20056

Department of Obstetrics and Gynecology.

Rationale: Cervical cancer primarily spreads through direct invasion or via local lymphatics, and hematogenous metastasis is infrequent. Previous reports have shown that lung, liver, and bone are the organs most frequently affected by hematogenous metastasis of cervical cancer, while skeletal muscle is very rarely involved.

Patient Concerns: A 75-year-old Japanese woman presented with a painful muscular mass in her right lower abdomen. Read More

Medicine (Baltimore) 2020 May;99(19):e20054

Department of Hepatobiliary Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, P. R. China.

Rationale: Patent foramen ovale (PFO) is not considered to be the main cause of stroke and is classified as the infarction of undetermined cause. The relationship between PFO and cerebral embolism is still unclear and cerebral embolism accompanied with coronary artery embolization in PFO patient is rare. In this case, we reported a patient with PFO suffered acute cerebral and myocardial infarction simultaneously, and analyzed the source of emboli and potential pathogenesis. Read More

Medicine (Baltimore) 2020 May;99(19):e20051

Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital.

Introduction: Hepatoid carcinoma of the ovary (HCO) is a rare disease that originates from the ovarian surface epithelium. It is histologically characterized as hepatocellular carcinoma (HCC) with a hepatocyte-rich granular cytoplasm.

Patient Concerns: A 65-year-old female patient was admitted with complaints of indigestion, abdominal bloating, and pain. Read More

Medicine (Baltimore) 2020 May;99(19):e19962

Department of Internal Medicine.

Introduction: After tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 were introduced for the treatment of chronic myeloid leukemia, clinical outcomes have improved dramatically. However, together with the increase in the survival rate, a more frequent occurrence of secondary malignancies has been observed as well. TKIs have been demonstrated to be a risk factor of malignancies such as non-Hodgkin lymphoma, prostate cancer, and skin cancer. Read More

BMC Infect Dis 2020 May 7;20(1):327. Epub 2020 May 7.

Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.

Background: Tularemia, a re-emerging, potential life threatening infectious disease, can present itself with nonspecific clinical symptoms including fever, chills and malaise. Taking a detailed history of exposure and a highly raised index of clinical suspicion are necessary to take the appropriate diagnostic and therapeutic steps in this setting. Here, a case report of typhoid tularaemia is presented. Read More

J Bone Joint Surg Am 2020 05;102(9):750-758

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Background: Studies of the novel coronavirus-induced disease COVID-19 in Wuhan, China, have elucidated the epidemiological and clinical characteristics of this disease in the general population. The present investigation summarizes the clinical characteristics and early prognosis of COVID-19 infection in a cohort of patients with fractures.

Methods: Data on 10 patients with a fracture and COVID-19 were collected from 8 different hospitals located in the Hubei province from January 1, 2020, to February 27, 2020. Read More

N Engl J Med 2020 May;382(19):1844-1849

From the Department of Internal Medicine, Sections of Gastroenterology, Hepatology, and Nutrition (D.M., M.R.C.) and Infectious Diseases (J.-L.B.), and the Department of Radiology (A.O.), University of Chicago Medicine, and the Department of Internal Medicine, University of Chicago Medicine, and the MacLean Center for Clinical Medical Ethics, University of Chicago (M.S.) - all in Chicago.

Clin Res Hepatol Gastroenterol 2020 06 27;44(3):282-283. Epub 2020 Apr 27.

Infectious Diseases Department, Nord Franche-Comté Hospital, site de Belfort, 90016 Belfort, France. Electronic address:

In a retrospective study in the Nord Franche-Comté hospital conducted between March 1st and March 17th 2020, and compared to the review of Li et al., diarrhea was a main symptom in patients with COVID-19. Out of the 114 patients, 55 (48%) had diarrhea; it was the fifth most common symptom. Read More

Liver Int 2020 07 20;40(7):1590-1593. Epub 2020 May 20.

Division of Hepatology at Sandra Atlas Bass Center for Liver Diseases & Transplantation, Manhasset, NY, USA.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious viral disease that predominantly causes respiratory symptoms. Elevated liver enzymes have been reported during the course of disease and appear to be common. We present a 56-year-old woman with a history of decompensated alcoholic cirrhosis who presented with abdominal pain, fever and diarrhoea and was found to have acute on chronic liver failure secondary to SARS-CoV-2 infection. Read More

Anticancer Res 2020 May;40(5):2969-2974

Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy.

Background: Although oncological results for resection of colon cancer with inferior mesenteric artery (IMA) ligation at its origin (high tie) or immediately below the left colic artery (low tie) are similar, injury of the superior hypogastric plexus may be caused when the IMA is tied at its origin, thus impairing defecatory functions.

Aim: The importance of IMA tie location on defecatory dysfunction in patients undergoing laparoscopic sigmoidal resection without preoperative radiation therapy was studied.

Patients And Methods: From February 2013 to December 2018, 56 consecutive patients submitted to curative laparoscopic resection for stage II and III, M0, sigmoidal cancer were randomized to a high or low tie of the IMA. Read More

Medicine (Baltimore) 2020 May;99(18):e19738

Division of Gastroenterology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University.

Rationale: Scrotal swelling is a rare complication of acute pancreatitis. It had been explained by fluid accumulation in scrotum originated from abdomen. Here we demonstrated a case of recurrent pancreatitis with hydrocele caused by impaired testicular venous drainage. Read More

Br J Surg 2020 Jun 28;107(7):e186-e187. Epub 2020 Apr 28.

Section for Upper Gastrointestinal Surgery, Department of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Ullevaal, Norway.

Ann Emerg Med 2020 05;75(5):576-586

Department of Radiology, Lincoln Medical and Mental Health Center, Bronx, NY.

Medicine (Baltimore) 2020 Apr;99(17):e19890

Department of Gastroenterology, Shanghai Hospital of Integrated Traditional Chinese and Western Medicine.

Rationale: Dabigatran is an anticoagulant medication that has been widely used to prevent strokes caused by atrial fibrillation, deep vein thrombosis, and pulmonary embolism. However, the potential adverse effect of dabigatran of gastrointestinal mucosal injury is often neglected, and even induces esophagitis.

Patient Concerns: A 77-year-old woman was admitted to the hospital with symptoms of progressive retrosternal pain, upper abdominal discomfort, and dysphagia. Read More

Medicine (Baltimore) 2020 Apr;99(17):e19783

Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College.

Introduction: Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor that is most common in the pleura. However, according to previous studies, the SFT of the pancreas is extremely rare; only 20 cases have been reported so far. Here, we conduct a literature review and report the first case of atypical/malignant SFT of the pancreas with spleen vein invasion. Read More

BMC Infect Dis 2020 Apr 21;20(1):293. Epub 2020 Apr 21.

Center for International Health, University of Munich (LMU), Munich, Germany.

Background: The 2013-2016 West Africa Ebola Virus Disease (EVD) outbreak recorded the highest incidence and mortality since the discovery of the virus in Zaire in 1976; with more than 28,000 probable and confirmed EVD cases and 11,000 deaths. Studies relating to previous outbreaks usually involved small sample sizes. In this study we are set to identify those sociodemographic and clinical features that predict in-facility mortality among EVD patients using a large sample size. Read More

Ann Surg 2020 07;272(1):e38-e39

Department of General Surgery, Chinese PLA General Hospital, Beijing, China.

Am J Gastroenterol 2020 05;115(5):766-773

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms.

Methods: In this descriptive, cross-sectional, multicenter study, we enrolled confirmed patients with COVID-19 who presented to 3 hospitals from January 18, 2020, to February 28, 2020. Read More

AJR Am J Roentgenol 2020 06 14;214(6):1311-1315. Epub 2020 Apr 14.

Department of Radiology, Rose Medical Center, Denver, CO.

The study objectives were to evaluate the percentage of patients interested in immediate radiologic results and to measure patient anxiety and hospital loyalty with this program in a private practice community hospital setting. Between December 2018 and May 2019, 100 patients 18-89 years old with a primary diagnosis of abdominal pain had imaging orders for CT, ultrasound, or nuclear medicine-hepatobiliary iminodiacetic acid scans and subsequently were asked if they wanted immediate results. Those who opted for immediate results were given a two-question survey before and after results delivery that asked about their anxiety level and imaging center loyalty. Read More

Medicine (Baltimore) 2020 Apr;99(15):e19508

Department of General Surgery, Dongfang Hospital, Xiamen University.

Introduction: Gastrointestinal perforation due to foreign body intake is rare and often secondary to unintentional intake; hence, a misdiagnosis is likely. Herein, we report a case of perforation of the ileum due to fish bone.

Case Presentation: A 57-year-old woman presented with right lower abdominal pain. Read More

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(4):345-353

Department of Pathology, Meitetsu Hospital.

A 78-year-old woman with a chief complaint of mammary tumor was referred to our hospital and was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma using needle biopsies. She presented with MALT lymphoma lesions in the stomach, duodenum, and intraperitoneal lymph nodes. Abdominal ultrasonography revealed thickened internal layer of the bile duct. Read More

Vasc Endovascular Surg 2020 Jul 13;54(5):389-394. Epub 2020 Apr 13.

Department of Interventional Radiology, Queen Elizabeth Hospital, Birmingham, United Kingdom.

Background And Aims: The management of persistent type II endoleaks (T2E) is often problematic for the endovascular specialist, with a lack of clear evidence for the best approach for embolization. The aim of this study was to evaluate the safety and efficacy of translumbar embolization (TLE) for T2E following endovascular aneurysm repair (EVAR).

Methods: This retrospective review included 27 embolizations performed on 23 patients with a median age of 78 (range 67-94 years; male: female 15:9), during the period September 2006 to July 2018. Read More

Crit Care 2020 04 10;24(1):144. Epub 2020 Apr 10.

Department of Pharmacology, Toxicology and Biochemistry, Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: Acute kidney injury (AKI) is a frequently occurring syndrome in critically ill patients and is associated with worse outcomes. Biomarkers allow early identification and therapy of AKI which may improve outcomes. Urine chitinase 3-like protein 1 (uCHI3L1) was recently identified as a promising urinary biomarker for AKI. Read More

PLoS One 2020 10;15(4):e0231398. Epub 2020 Apr 10.

Section of Gastroenterology and Department of Medicine, Aga Khan University, Karachi, Pakistan.

Background And Aim: In light of few established drug induced liver injury (DILI) registries, this study aims to evaluate the clinical spectrum and predictors of mortality and morbidity of hospitalized patients with suspected DILI.

Patients And Methods: DILI cases were identified and categorized on basis of COIMS/RUCAM score and the exclusion of other liver diseases. Clinical and laboratory parameters were analyzed to identify the predictors of morbidity (prolonged hospital stay > 5 days) and mortality. Read More