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Medicine (Baltimore) 2019 Feb;98(6):e14406

Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Rationale: We present a case of high spinal anesthesia after inadvertent injection of local anesthetics and corticosteroids into the subarachnoid space during attempted epidural injection. Cerebrospinal fluid (CSF) lavage is a suitable method for treatment.

Patient Concerns: A 45-year-old woman presented with posterior thigh, leg, and ankle pain for >6 months and was treated with epidural injection. Read More

Lancet Haematol 2019 Feb;6(2):e100-e109

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Therapeutic approaches for B-cell malignancies continue to evolve, especially with regard to combination approaches. We assessed the safety and efficacy of the triplet ublituximab, umbralisib, and ibrutinib in patients with advanced B-cell malignancies.

Methods: We did an open-label, phase 1 study with dose-escalation and dose-expansion phases, at five centres in the USA. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14326

Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79# Qingchun Road.

Rationale: Colorectal cancer (CRC) is one of the most common cancers all over the world, and approximately 70% of the newly diagnosed patients are over 65 years old. Due to the aging of society, there will be more and more elderly patients of CRC in the future. Treatment of CRC in elderly patients is much more challenging thanks to multiple factors including disabling comorbidities as well as declines in organs function, especially in advanced or metastatic settings. Read More

Ter Arkh 2018 Apr;90(4):17-20

I.P. Pavlov Ryazan State Medical.

Aim: Determination of the prevalence of Helicobacter pylori infection (H. pylori) among the urban population.

Materials And Methods: 655 people (638 adults and 17 children) were examined using the immunoassay method of quantitative detection of IgG class antibodies. Read More

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

N Engl J Med 2019 Jan;380(4):379

University of Florence, Florence, Italy

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):50-53

Department of Urology, Toyohashi Municipal Hospital.

A 77-year-old man with a right kidney stone was admitted to our hospital. A ureteroscope was introduced into the ureter without dilation under direct vision. We then performed flexible transurethral lithotripsy (f-TUL) using a ureteral access sheath and successfully fragmented the stone and extracted almost all the stone fragments without any complications. Read More

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):35-39

Department of Urology, Iwate Medical University.

A 45-years-old man presented discharge of abscess from the umbilicus with lower abdominal pain. CT scan showed huge tumor from the bladder to the umbilical part with sigmoid colon invasion. He was diagnosed as urachal carcinoma, which was confirmed by pathological examination. Read More

World J Surg Oncol 2019 Jan 18;17(1):21. Epub 2019 Jan 18.

Department of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City, 110001, People's Republic of China.

Background: Bowel obstruction (BO) is a complication that commonly affects patients with colorectal cancer (CRC). BO causes severe outcomes, and its treatment leads to a dilemma for many surgeons. Moreover, the factors correlated to BO in preoperative CRC patients remain unclear. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14206

Department of Radiology, Mayo Clinic, Rochester, MN.

Rationale: Epstein-Barr virus (EBV)-related lymphoepithelioma-like cholangiocarcinoma (LELCC) is an extremely rare primary liver tumor with nonspecific clinical manifestations. The clinicopathological features of EBV-associated LELCC have been reported in a few cases. But reports of the tumor's imaging characteristics, particularly ultrasonographic findings, are very rare. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

J Radiol Case Rep 2018 Oct 31;12(10):17-23. Epub 2018 Oct 31.

Department of Radiology, Hahnemann University Hospital, Philadelphia, PA, USA.

This case report depicts the radiologic findings of a 51-year-old male presenting with Decompression Sickness. Decompression Sickness is diagnosed clinically, therefore radiologic imaging of this disease entity is limited. Our patient's history includes a scuba dive to depth of 110 feet with a descending time of 24 minutes and an ascending time of 8 minutes. Read More

World J Gastroenterol 2019 Jan;25(1):107-117

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.

Background: Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide (TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.

Aim: To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.

Methods: Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Read More

World J Gastroenterol 2019 Jan;25(1):95-106

Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka.

Background: Abdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs) are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood.

Aim: To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs. Read More

Nutrients 2019 Jan 10;11(1). Epub 2019 Jan 10.

Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20135 Milan, Italy.

It is unclear whether patients with non-celiac gluten sensitivity (NCGS) can tolerate gluten. We have evaluated the changes of both gastrointestinal symptoms and quality of life for NCGS patients after the re-introduction of dietary gluten. Twenty-two NCGS patients reporting functional gastroenterological symptoms and on gluten-free diet (GFD) for the previous three weeks were exposed to incremental gluten-containing diets. Read More

Medicine (Baltimore) 2019 Jan;98(2):e14087

Department of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul.

Backgroud: The purpose of this study was to evaluate the effects of trigger point injection (TPI) and eutectic mixture local anesthetics (EMLA) cream on the postoperative shoulder pain in patients undergoing total laparoscopic hysterectomy.

Methods: In this randomized, single-blinded, and controlled study, total 75 patients were randomly allocated to TPI group (n = 25), EMLA group (n = 25), and control group (n = 25). TPI group received TPIs with 2 mL of 0. Read More

Pan Afr Med J 2018 6;30:252. Epub 2018 Aug 6.

Service de Pneumologie de l'Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc.

Smoking is the leading cause of preventable death worldwide, it is responsible for 90% of bronchopulmonary cancers and is the main cause of chronic bronchitis and emphysema, two disorders which contribute to chronic obstructive pulmonary disease (COPD). We here report the case of a 58-year old not weaned chronic tabagic patient with a 2-month history of diffuse abdominal pain evolving in a context of alteration of the general state. Clinical examination showed generally poor health. Read More

BMC Surg 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Background: The spontaneous rupture of the gallbladder is extremely rare, majority of ruptures occur secondary to traumatic injuries. Here, we report a case of spontaneous rupture of the gallbladder with probably cause of oral anticoagulants.

Case Presentation: A 51-year-old woman presented to the emergency room with sudden-onset severe abdominal pain, as well as hypotension and low level of hemoglobin. Read More

Medicine (Baltimore) 2019 Jan;98(1):e13994

Department of Anesthesiology and Reanimation, Mugla Sitki Kocman University, Mugla, Turkey.

Background: We aimed to assess whether an ultrasound (US)-guided oblique subcostal transversus abdominis plane (OSTAP) block would improve the postoperative pain scores and decrease the tramadol consumption after a laparoscopic hysterectomy.

Methods: Sixty-six female patients with American Society of Anesthesiologists I, II, or III, aged 18 to 65 years who were scheduled for laparoscopic hysterectomy for benign gynecologic pathologies were recruited in this randomized, controlled, observer-blinded trial. Sixty patients completed the study. Read More

Clin Infect Dis 2019 Jan 2. Epub 2019 Jan 2.

Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States.

Background: The early detection of enteric infections in older adults is challenging because typical signs and symptoms of disease may be less common, absent, or overlooked. Understanding illness characteristics of enteric infections among older adults could improve the timeliness and accuracy of clinical diagnoses, thereby improving patient outcomes and increasing cases reported to surveillance.

Methods: This study describes illness characteristics (percentage reporting bloody diarrhea, fever, vomiting, abdominal pain, percentage hospitalized, duration of hospitalization, and duration of illness) among older adults (≥65 years) with acute gastroenteritis and culture-confirmed Campylobacter and nontyphoidal Salmonella infections in Australia, Canada, and the United States, and compares these characteristics with those among younger adults (25-64 years) and children (<5 years, 5-24 years). Read More

Medicine (Baltimore) 2018 Dec;97(52):e13659

Rationale: The incidence of spontaneous perforations in pyometra occurs rarely, only 0.01% to 0.5% in gynecological patients, with high mortality and morbidity. Read More

BMC Infect Dis 2018 Dec 27;18(1):699. Epub 2018 Dec 27.

Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, 15, Jinju-daero 816 beon-gil, Jinju-si, Gyeongnam, 52727, Republic of Korea.

Background: Abdominal tuberculosis (TB) is an uncommon form of infection with Mycobacterium tuberculosis in Korea. In this study, we aimed to highlight the clinical features, diagnostic methods, and outcomes of abdominal TB over 12 years in Southeastern Korea.

Methods: A total of 139 patients diagnosed as having abdominal TB who received anti-TB medication from January 2005 to June 2016 were reviewed. Read More

Maturitas 2019 Feb 19;120:7-11. Epub 2018 Nov 19.

Emergency Department, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy. Electronic address:

Objectives: Globally, the average age of the population is increasing. Patients aged >65 years attending hospital emergency departments (EDs) differ from younger patients; in particular, they often present with multiple comorbidities. Our retrospective study evaluates the number of attendances at our ED by elderly patients in the 12 years from January 2005 to December 2017. Read More

BMC Surg 2018 Dec 22;18(1):120. Epub 2018 Dec 22.

Department of General Surgery, Taizhou Central Hospital, Taizhou University Hospital, Taizhou, 318000, China.

Background: The diagnosis of paraduodenal hernia is still a challenge in clinical practice due to lacking of specific symptoms.

Case Presentation: An 83-yr-old male patient presented to our department due to severe abdominal pain for 8 h. Abdominal contrast enhanced computerized tomography (CT) scan indicated intussusception in the duodenum and the upper segment of jejunum, as well as internal hernia. Read More

Transplant Proc 2018 Dec 6;50(10):4004-4007. Epub 2018 Sep 6.

Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China; Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. Electronic address:

Congenital hepatic arteriovenous fistulae (CHAVF) are direct communications between the hepatic artery and portal vein or hepatic vein. Clinical symptoms of CHAVF depend mainly on the location, duration, and blood flow volume of the fistulae, which are manifested by portal hypertension, hepatic fibrosis, cardiac enlargement, and eventually heart failure. Here we report a female patient aged 54 who was first admitted to our hospital due to recurrent chest tightness and palpitations in March 2014. Read More

Transplant Proc 2018 Dec 7;50(10):3656-3660. Epub 2018 Sep 7.

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Introduction: In the era of rituximab, ABO-incompatible living-donor liver transplantation (ABOi LDLT) is clinically accepted as a feasible therapy for end-stage liver disease. To date, no data on postoperative sarcopenic changes in patients undergoing ABOi LDLT are available.

Patients And Methods: Thirty-six adult patients undergoing ABOi LDLT between October 2010 and July 2017 at our hospital were retrospectively analyzed. Read More

Pan Afr Med J 2018 25;30:225. Epub 2018 Jul 25.

Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire Avicenne, Rabat, Maroc.

Pseudomyxoma peritonei (PMP) is a clinicopathologic syndrome characterized by mucinous ascites and pools of mucin resulting in neoplastic mucinous epithelium in the peritoneal cavity. PMP is uncommon and it is characterized by clinical and unusual pathologic manifestations posing diagnostic and therapeutic problems. Involvement of abdominal viscera and lymph node metastases are rare and sporadic cases have been reported in the literature. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13628

Trauma Emergency Center, Department of Orthopaedics, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.

Rationale: Primary iliopsoas abscess (IPA), an uncommon clinical entity, often has no specific clinical features, and advanced imaging techniques are often required for diagnosis.

Patient Concerns: We successfully treated 3 patients with primary IPA complicated by rapid development of septic shock within 2 months.

Diagnosis: All patients were in shock at the time of admission and were diagnosed with primary IPA by history, clinical examination and imaging findings. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13712

Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Rationale: Currently, the mainstream treatment for gastric bezoars is endoscopic lithotripsy. This report describes traditional Chinese medicine (TCM) purgative cured a 62-year-old woman with a huge gastric bezoar accompanied by isolated esophageal venous aneurysms and multiple bleeding gastric ulcers.

Patient Concerns: A 62-year-old woman with several symptoms, including epigastric pain, nausea, and vomiting, hiccups, heartburn, and dark, loose stools. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13608

Department of Cardiology, the First Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Primary aldosteronism (PA) with hypokalemia increases the risk of life-threatening ventricular arrhythmias. Cases of PA with malignant arrhythmia as the first symptom have been reported. The role of severe hypokalemia in triggering malignant ventricular arrhythmia is well documented. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13423

Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Rationale: Primary gastric inflammatory myofibroblastic tumor is extremely rare. Only a few cases were reported in the domestic and foreign medical literature with corresponding imaging findings of this disease even more rarely reported.

Patient Concerns: We present one case of a 52-year-old female patient with upper abdominal pain, acid reflux, and belching for 2 months. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13285

Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.

Rationale: Hemobilia caused by arteriovenous malformation is extremely rare but could be lethal. To date, most reports have been single-case reports, and no literature reviews are available.

Patient Concerns: A 47-year-old man presented to the emergency department with abdominal pain and fever. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13072

Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju.

Rationale: Self-expanding metal stent placement is a useful procedure for intestinal obstruction. Afferent loop syndrome after gastrectomy is an uncommon complication of gastroenterostomy reconstruction. Ascending cholangitis caused by afferent loop syndrome is a potential, but rare, complication. Read More

Arch Pediatr 2019 Jan 13;26(1):34-37. Epub 2018 Dec 13.

Faculty of Health Sciences of Bangui University, Central African Republic; National Laboratory of Clinical Biology and Public Health of Bangui, Central African Republic.

Objective: To describe the epidemiological and clinical profile of intestinal parasites in children in rural Central African Republic.

Patients And Methods: We conducted a multicenter cross-sectional study in Central African Republic rural areas. Children seen as outpatients regardless of the reason for consultation were included in the study after parental consent. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13546

Department of Thoracic Surgery, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China.

Rationale: The case of parasternal diaphragmatic hernia is relatively rare in adults. The best way for the treatment of diaphragmatic hernia is to receive operation, yet which surgical method is the best remains unclear.

Patient Concerns: An elderly woman in the hospital was complaining about upper abdominal pain that was complicated by the parasternal diaphragmatic hernia. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13538

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei.

Rationale: Autonomic symptoms are not uncommon in chronic inflammatory demyelinating polyneuropathy (CIDP), but they are mostly mild and transient and are overshadowed by somatic manifestations. Here, we report a very unusual case of CIDP with severe autonomic symptom, intestinal obstruction, as initial and persistent symptom which responded well to high-dose glucocorticoid and intravenous immunoglobulin treatment.

Patient Concerns: We described a patient with CIDP with precedent and long-lasting incomplete intestinal obstruction. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13469

Department of Emergency Surgery, Union Hospital.

Rationale: About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.

Patient Concerns: A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13426

Department of Colorectal Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: Complete small bowel obstruction (SBO) is a common surgical emergency often resulting from adhesive bands installed after a surgical procedure. However, SBO caused by surgical staples used in a previous operation is unusual. Herein, we report a rare case of adhesive ileus induced by surgical staples. Read More

Soins Gerontol 2018 Jul - Aug;23(132):17-20

Service de médecine gériatrique, Hupifo, site Ambroise-Paré (AP-HP), 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address:

There are numerous indications for gastrointestinal endoscopies in elderly people. These include notably bleeding of the digestive tract, unexplained anorexia, abdominal pain, a pathology of the colon or screening for cancerous lesions. These examinations are carried out by a multidisciplinary team. Read More

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):753-760

Disciplina de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.

Introduction: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemorrhagic fever (DHF) and death. Read More

Drugs Aging 2019 01;36(1):13-27

Division of Gastroenterology, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box: 24502B, Tucson, AZ, 85724, USA.

The incidence rate of ulcerative colitis (UC) in older patients is rising. Diagnosis of UC may be difficult in older patients as several common gastrointestinal disorders can mimic UC in these patients. Compared with younger adults, left-sided colitis is more common in older-onset UC, while rectal bleeding, abdominal pain, and extraintestinal manifestations are less common. Read More

BMC Infect Dis 2018 Dec 4;18(1):620. Epub 2018 Dec 4.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Gastrointestinal (GI) cryptococcosis is rarely reported. Most cases were diagnosed during evaluation of comorbid conditions, incidental findings, or postmortem. Here, we present a case of Crohn's disease with gastrointestinal cryptococcosis that resembled exacerbation of Crohn's disease. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13446

Department of General and Gastroenterological Surgery, Osaka Medical College, Daigaku-machi, Takatsuki.

Rationale: Liposarcoma (LPS) is a rare malignant soft-tissue tumor. Management of LPS is relatively difficult, because there are no characteristic symptoms, or biomarkers, nor any established effective treatment. Hence, the report of the accumulation of each LPS case is necessary. Read More

Fa Yi Xue Za Zhi 2018 Aug 25;34(4):384. Epub 2018 Aug 25.

School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.

Objectives: To study the epidemiological and pathological features of sudden death （SD） in Yunnan Province and to provide scientific evidence for prevention and forensic identification of sudden death.

Methods: Totally 363 SD cases were collected from the autopsies between 2009 and 2017 in the Forensic Centre of Kunming Medical University. The related factors such as etiology, age, inducing factor, time interval between the onset of disease and death, morbidity season and pathological change were retrospectively analysed. Read More

N Engl J Med 2018 Nov;379(21):e37

Peking Union Medical College Hospital, Beijing, China

Medicine (Baltimore) 2018 Nov;97(47):e13368

Department of General and Gastroenterological Surgery.

Rationale: Hepatic portal vein gas (HPVG) is known as a sign of a lethal condition resulting from bowel necrosis. Recently, the detection rate of non-life-threatening cases of HPVG has increased due to the technological development of imaging, i.e. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13328

Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Jinan, China.

Rationale: Radiation enteritis (RE) is one of the serious complications caused by the radiotherapy and it can occur in any segment of the intestine, including small intestine, colon, and rectum. It can cause a number of serious problems of the intestine, such as chronic ulcers, bleeding, intestinal stenosis, intestinal fistula, and perforation. At present, there is no standard treatment guideline for the RE. Read More

Acta Clin Croat 2018 Jun;57(2):362-365

Department of Hematology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

T-cell large granular lymphocytic leukemia (T-LGLL) is an uncommon but probably underdiagnosed disease caused by clonal proliferation of large granular lymphocytes. Diagnosis is typically based on the high number of morphologically characteristic lymphoid cells and finding of an abnormal immunophenotype by flow cytometry. Because of its relatively indolent clinical behavior, observation is often an appropriate therapy. Read More