Carbohydr Polym 2021 Aug 12;265:118066. Epub 2021 Apr 12.
Department of Biotechnology, Middle East Technical University, Ankara, 06800, Turkey; Department of Engineering Sciences, Middle East Technical University, Ankara, 06800, Turkey; BIOMATEN Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, Ankara, 06800, Turkey. Electronic address:
This study aims to develop a novel intraperitoneal two- or three-layered patch with immunomodulatory property for treatment of hernia, regeneration of abdominal wall and prevention of intraperitoneal adhesions. Polypropylene (PP) mesh, middle layer, was intended to provide mechanical support whereas pullulan (PUL) hydrogel coating layer was designed to prevent intraperitoneal adhesions. Fibroin/chitosan oligosaccharide lactate (F/COS) layer electrospun on one side of pullulan was chosen for immunomodulation and abdominal wall regeneration. Read More