296 results match your criteria ASN neuro[Journal]


Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice.

ASN Neuro 2020 Jan-Dec;12:1759091420930865

Department of Biological Sciences, Rutgers University, Newark, New Jersey, United States.

The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, with only a few neuronal subpopulations retaining expression into adulthood. However, p75NTR expression is induced following damage to the adult brain, including after traumatic brain injury, which is a leading cause of mortality and disability worldwide. Read More

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http://dx.doi.org/10.1177/1759091420930865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273561PMC

Early Cognitive Impairment Behind Nigrostriatal Circuit Neurotoxicity: Are Astrocytes Involved?

ASN Neuro 2020 Jan-Dec;12:1759091420925977

Instituto de Farmacología Experimental de Córdoba (IFEC-CONICET), Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba.

Cognitive dysfunction is one of the most severe nonmotor symptoms of nigrostriatal impairment. This occurs as a result of profound functional and morphological changes of different neuronal circuits, including modifications in the plasticity and architecture of hippocampal synapses. Such alterations can be implicated in the genesis and progression of dementia associated with neurodegenerative diseases including Parkinson-like symptoms. Read More

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http://dx.doi.org/10.1177/1759091420925977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263115PMC
May 2020
4.017 Impact Factor

Shedding Light on the Dark Side of the Microglia.

ASN Neuro 2020 Jan-Dec;12:1759091420925335

Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval.

Microglia, the resident immune cells of the central nervous system, are not a homogeneous population; their morphology, molecular profile, and even their ultrastructure greatly vary from one cell to another. Recent advances in the field of neuroimmunology have helped to demystify the enigma that currently surrounds microglial heterogeneity. Indeed, numerous microglial subtypes have been discovered such as the disease-associated microglia, neurodegenerative phenotype, and Cd11c-positive developmental population. Read More

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http://dx.doi.org/10.1177/1759091420925335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249604PMC

Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus.

ASN Neuro 2020 Jan-Dec;12:1759091420926836

Department of Neurology, First Affiliated Hospital, Kunming Medical University.

Nuclear-distribution element-like 1 (NDEL1) is associated with the proliferation and migration of neurons. Vascular endothelial growth factor (VEGF) in combination with VEGF receptor-2 (VEGFR-2) regulates the proliferation and migration of neurons. This study was performed to explore undefined alterations in the expression levels of NDEL1 and VEGF/VEGFR-2 within the hippocampus after status epilepticus (SE). Read More

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http://dx.doi.org/10.1177/1759091420926836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238446PMC

Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease.

ASN Neuro 2020 Jan-Dec;12:1759091420925356

Department of Psychiatry and Psychotherapy, Molecular Psychiatry, University Medical Center (UMG), Georg-August-University, Göttingen, Germany.

The deposition of amyloid-β peptides in the form of extracellular plaques and neuronal degeneration belong to the hallmark features of Alzheimer's disease (AD). In addition, impaired calcium homeostasis and altered levels in calcium-binding proteins seem to be associated with the disease process. In this study, calretinin- (CR) and parvalbumin- (PV) positive gamma-aminobutyric acid-producing (GABAergic) interneurons were quantified in different hippocampal subfields of 12-month-old wild-type mice, as well as in the transgenic AD mouse models 5XFAD and Tg4-42. Read More

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http://dx.doi.org/10.1177/1759091420925356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238451PMC

Diffusion Tensor Imaging Detects Acute and Subacute Changes in Corpus Callosum in Blast-Induced Traumatic Brain Injury.

ASN Neuro 2020 Jan-Dec;12:1759091420922929

Center for Basic M.R. Research, Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois, United States.

There is a critical need for understanding the progression of neuropathology in blast-induced traumatic brain injury using valid animal models to develop diagnostic approaches. In the present study, we used diffusion imaging and magnetic resonance (MR) morphometry to characterize axonal injury in white matter structures of the rat brain following a blast applied via blast tube to one side of the brain. Diffusion tensor imaging was performed on acute and subacute phases of pathology from which fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were calculated for corpus callosum (CC), cingulum bundle, and fimbria. Read More

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http://dx.doi.org/10.1177/1759091420922929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238783PMC

VISSA-PLS-DA-Based Metabolomics Reveals a Multitargeted Mechanism of Traditional Chinese Medicine for Traumatic Brain Injury.

ASN Neuro 2020 Jan-Dec;12:1759091420910957

Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University.

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http://dx.doi.org/10.1177/1759091420910957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066589PMC

Spatiotemporal Distribution of Microglia After Traumatic Brain Injury in Male Mice.

ASN Neuro 2020 Jan-Dec;12:1759091420911770

Department of Pediatric Surgery, McGovern Medical School, University of Texas Health Science Center at Houston.

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http://dx.doi.org/10.1177/1759091420911770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066592PMC

NRF2 as a Therapeutic Target in Neurodegenerative Diseases.

ASN Neuro 2020 Jan-Dec;12:1759091419899782

Department of Neurology, Oregon Health and Science University, Portland, OR, USA.

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http://dx.doi.org/10.1177/1759091419899782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977098PMC
January 2020

Physical Activity and Cognitive Function in Mild Cognitive Impairment.

Authors:
Ya-Ting Chang

ASN Neuro 2020 Jan-Dec;12:1759091419901182

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung.

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http://dx.doi.org/10.1177/1759091419901182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970452PMC
January 2020

Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells.

ASN Neuro 2019 Jan-Dec;11:1759091419892713

CIQUIBIC-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

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http://dx.doi.org/10.1177/1759091419892713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909277PMC

Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer's Disease.

ASN Neuro 2019 Jan-Dec;11:1759091419892692

Department of Psychiatry and Psychotherapy, Molecular Psychiatry, University Medical Center (UMG), Georg-August-University, Göttingen, Germany.

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http://dx.doi.org/10.1177/1759091419892692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906584PMC

Intracerebroventricular Infusion of Gangliosides Augments the Adult Neural Stem Cell Pool in Mouse Brain.

ASN Neuro 2019 Jan-Dec;11:1759091419884859

Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, GA, USA.

We previously reported that ganglioside GD3 is the predominant species in neural stem cells (NSCs) and reduced postnatal NSC pools are observed in both the subventricular zone and dentate gyrus (DG) of GD3-synthase knockout (GD3S-KO) mouse brains. Specifically, deficiency of GD3 in GD3S-KO animals revealed a dramatic reduction in cellularity in the DG of the hippocampus of the developing mouse brain, resulting in severe behavioral deficits in these animals. To further evaluate the functional role of GD3 in postnatal brain, we performed rescue experiments by intracerebroventricular infusion of ganglioside GD3 in adult GD3S-KO animals and found that it could restore the NSC pools and enhance the NSCs for self-renewal. Read More

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http://dx.doi.org/10.1177/1759091419884859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806120PMC

2019 Academic Annual Meeting and the Frontier Seminar on "Glial Cell Function and Disease" (Nantong, China).

ASN Neuro 2019 Jan-Dec;11:1759091419863576

2 Institute of Pain Medicine, Institute of Special Environmental Medicine, Nantong University, China.

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http://dx.doi.org/10.1177/1759091419863576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659189PMC

Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer's Disease Progression.

ASN Neuro 2019 Jan-Dec;11:1759091419855541

1 Department of Neurology, Center for Alzheimer's Disease and Related Disorders, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, IL, USA.

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http://dx.doi.org/10.1177/1759091419855541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582288PMC
May 2020
9 Reads

Higher Level of Mismatch in APOEε4 Carriers for Amyloid-Beta Peptide Alzheimer's Disease Biomarkers in Cerebrospinal Fluid.

ASN Neuro 2019 Jan-Dec;11:1759091419845524

1 Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Georg-August-University, Germany.

Cerebrospinal fluid (CSF) biomarkers are widely used in the diagnosis of dementia. Even though there is a causal correlation between apolipoprotein E ( APOE) genotype and amyloid-beta (Aβ), the determination of APOE is currently not supported by national or international guidelines. We compared parallel measured CSF biomarkers of two independent laboratories from 126 patients who underwent clinical dementia diagnostics regarding the APOE genotype. Read More

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http://dx.doi.org/10.1177/1759091419845524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535906PMC
May 2020
1 Read

Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus.

ASN Neuro 2019 Jan-Dec;11:1759091419843762

5 Department of Neurobiology, The University of Alabama at Birmingham, AL, USA.

In the supraoptic nucleus (SON), the incidence of dye coupling among oxytocin (OT) neurons increases significantly in nursing mothers. However, the type(s) of connexin (Cx) involved is(are) unknown. In this study, we specifically investigated whether Cx36 plays a functional role in the coupling between OT neurons in the SON of lactating rats. Read More

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http://dx.doi.org/10.1177/1759091419843762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535915PMC
May 2020
2 Reads

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways.

ASN Neuro 2019 Jan-Dec;11:1759091419839515

1 Warren Alpert Medical School of Brown University, Providence, RI, USA.

Background: Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology.

Objective: Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted us to measure a panel of trophic factors, receptors, and molecules that modulate brain metabolic function in FTLD.

Methods: Postmortem frontal (Brodmann's area [BA]8/9 and BA24) and temporal (BA38) lobe homogenates were used to measure immunoreactivity to Tau, phosphorylated tau (pTau), ubiquitin, 4-hydroxynonenal (HNE), transforming growth factor-beta 1 (TGF-β1) and its receptor (TGF-β1R), brain-derived neurotrophic factor (BDNF), nerve growth factor, neurotrophin-3, neurotrophin-4, tropomyosin receptor kinase, and insulin and insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2) and their receptors by direct-binding enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1177/1759091419839515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535914PMC
May 2020
15 Reads

Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress.

ASN Neuro 2019 Jan-Dec;11:1759091419838949

4 Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Busan, Korea.

During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells. This recharacterized Schwann cell guides newly regrowing axons to their destination and remyelinates reinnervated axons. This Schwann cell dynamics during Wallerian degeneration is associated with oxidative events. Read More

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http://journals.sagepub.com/doi/10.1177/1759091419838949
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http://dx.doi.org/10.1177/1759091419838949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498775PMC
April 2020
5 Reads

Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model.

ASN Neuro 2019 Jan-Dec;11:1759091419843393

1 Department of Pediatrics, Biological Sciences Division, The University of Chicago, IL, USA.

In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human disease, we analyzed end-stage (4 months) transcriptional changes associated with lack of TPP1 activity. Using RNA sequencing technology, Tpp1 expression changes in the forebrain/midbrain and cerebellum of 4-month-old homozygotes were compared with strain-related controls. Read More

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http://dx.doi.org/10.1177/1759091419843393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475859PMC
May 2020
11 Reads

Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures.

ASN Neuro 2019 Jan-Dec;11:1759091419833502

1 Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.

ATP- and adenosine-mediated signaling are prominent types of glia-glia and glia-neuron interaction, with an imbalance of ATP/adenosine ratio leading to altered states of excitability, as seen in epileptic seizures. Pannexin1 (Panx1), a member of the gap junction family, is an ATP release channel that is expressed in astrocytes and neurons. Previous studies provided evidence supporting a role for purinergic-mediated signaling via Panx1 channels in seizures; using mice with global deletion of Panx1, it was shown that these channels contribute in maintenance of seizures by releasing ATP. Read More

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http://dx.doi.org/10.1177/1759091419833502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415468PMC
April 2020
2 Reads

Sildenafil Inhibits Myelin Expression and Myelination of Oligodendroglial Precursor Cells.

ASN Neuro 2019 Jan-Dec;11:1759091419832444

1 Laboratory of Neuroimmunoendocrinology, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico.

Phosphodiesterases (PDEs) have previously been implicated in oligodendrocyte maturation and myelination of central nervous system axons. Sildenafil citrate is a phosphodiesterase inhibitor known to block PDE5, which also reduces inflammation in the experimental autoimmune encephalomyelitis demyelinating model. To find out whether this inhibitor might exert beneficial effects on central nervous system myelin repair activities, we investigated to what degree sildenafil modulates differentiation and maturation of cultured primary rat oligodendroglial precursor cells (OPCs). Read More

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http://dx.doi.org/10.1177/1759091419832444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410393PMC
April 2020
3 Reads

Subacute Transplantation of Native and Genetically Engineered Neural Progenitors Seeded on Microsphere Scaffolds Promote Repair and Functional Recovery After Traumatic Brain Injury.

ASN Neuro 2019 Jan-Dec;11:1759091419830186

3 Department of Biological Sciences, Rutgers University, Newark, NJ, USA.

There is intense interest and effort toward regenerating the brain after severe injury. Stem cell transplantation after insult to the central nervous system has been regarded as the most promising approach for repair; however, engrafting cells alone might not be sufficient for effective regeneration. In this study, we have compared neural progenitors (NPs) from the fetal ventricular zone (VZ), the postnatal subventricular zone, and an immortalized radial glia (RG) cell line engineered to conditionally secrete the trophic factor insulin-like growth factor 1 (IGF-1). Read More

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http://dx.doi.org/10.1177/1759091419830186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399762PMC
April 2020
4 Reads
4.017 Impact Factor

A Longitudinal Investigation of Sleep and Daytime Wakefulness in Children and Youth With Concussion.

ASN Neuro 2019 Jan-Dec;11:1759091418822405

6 Montreal Children's Hospital, McGill University Health Center, Montreal, Québec, Canada.

A high proportion of adults who sustain a concussion identify changes in their sleep during the acute stage, typically reporting an increased need for sleep or nonrestful sleep. Our understanding of sleep following concussion is less well understood within a pediatric population. In this study, we investigated the trajectory of sleep and daytime sleepiness in a prospective cohort of 40 children and youth (6-18 years old) with concussion, 40 age-and sex-matched healthy children and youth, and 40 with upper-extremity orthopedic injury. Read More

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http://journals.sagepub.com/doi/10.1177/1759091418822405
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http://dx.doi.org/10.1177/1759091418822405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343438PMC
April 2020
18 Reads

α-Synuclein Trafficking in Parkinson's Disease: Insights From Fly and Mouse Models.

ASN Neuro 2018 Jan-Dec;10:1759091418812587

1 School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Protein aggregation and accumulation are common pathological hallmarks in neurodegenerative diseases. To efficiently clear and eliminate such aggregation becomes an important cellular strategy for cell survival. Lewy bodies inclusion and aggregation of α-Synuclein (α-Syn) during the pathogenesis of Parkinson's disease (PD) serve as a good example and are potentially linked to other pathological PD features such as progressive dopaminergic neuron cell death, behavioral defects, and nonmotor symptoms like anosmia, cognitive impairment, and depression. Read More

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http://dx.doi.org/10.1177/1759091418812587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259071PMC
July 2019
1 Read

L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats.

ASN Neuro 2018 Jan-Dec;10:1759091418811021

1 Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Levodopa (L-DOPA) is still the most effective drug for the treatment of Parkinson's disease (PD). However, the long-term therapy often triggers L-DOPA-induced dyskinesia (LID). Metabotropic glutamate receptor type 5 (mGluR5) is abundant in the basal ganglia, and its inhibition is thought to modulate postsynaptic excitatory synaptic transmission and glutamate hyperactivity in PD and LID. Read More

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http://journals.sagepub.com/doi/10.1177/1759091418811021
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http://dx.doi.org/10.1177/1759091418811021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238196PMC
July 2019
3 Reads

Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction.

ASN Neuro 2018 Jan-Dec;10:1759091418810583

1 Department of Anatomy, College of Medicine, Konyang University, Daejeon, South Korea.

Hyperammonemia associated with overt hepatic encephalopathy (OHE) causes excitotoxic neuronal death through activation of the cytochrome C (CytC)-mediated mitochondria-dependent apoptotic pathway. We tested the therapeutic effect of nortriptyline (NT), a mitochondrial permeability transition pore (mPTP) blocker that can possibly inhibit mitochondrial CytC efflux to the cytosol on in vivo and in vitro OHE models. After ensuring the generation of OHE rats, established by bile duct ligation (BDL), they were intraperitoneally administered either 20 mg/kg NT (i. Read More

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http://journals.sagepub.com/doi/10.1177/1759091418810583
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http://dx.doi.org/10.1177/1759091418810583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238202PMC
July 2019
41 Reads

An In Vitro Model of Charcot-Marie-Tooth Disease Type 4B2 Provides Insight Into the Roles of MTMR13 and MTMR2 in Schwann Cell Myelination.

ASN Neuro 2018 Jan-Dec;10:1759091418803282

1 Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.

Charcot-Marie-Tooth Disorder Type 4B (CMT4B) is a demyelinating peripheral neuropathy caused by mutations in myotubularin-related (MTMR) proteins 2, 13, or 5 (CMT4B1/2/3), which regulate phosphoinositide turnover and endosomal trafficking. Although mouse models of CMT4B2 exist, an in vitro model would make possible pharmacological and reverse genetic experiments needed to clarify the role of MTMR13 in myelination. We have generated such a model using Schwann cell-dorsal root ganglion (SC-DRG) explants from Mtmr13 mice. Read More

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http://journals.sagepub.com/doi/10.1177/1759091418803282
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http://dx.doi.org/10.1177/1759091418803282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236487PMC
July 2019
16 Reads

Sensory Processing Phenotypes in Fragile X Syndrome.

ASN Neuro 2018 Jan-Dec;10:1759091418801092

1 Division of Biomedical Sciences, University of California Riverside School of Medicine, CA, USA.

Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual disability. It is a leading known genetic cause of autism. In addition to cognitive, social, and communication deficits, humans with FXS demonstrate abnormal sensory processing including sensory hypersensitivity. Read More

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http://dx.doi.org/10.1177/1759091418801092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149018PMC
July 2019
5 Reads

Continuous Inhalation Exposure to Fungal Allergen Particulates Induces Lung Inflammation While Reducing Innate Immune Molecule Expression in the Brainstem.

ASN Neuro 2018 Jan-Dec;10:1759091418782304

1 BREATHE Center, University of California, Riverside, CA, USA.

Continuous exposure to aerosolized fine (particle size ≤2.5 µm) and ultrafine (particle size ≤0.1 µm) particulates can trigger innate inflammatory responses in the lung and brain depending on particle composition. Read More

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http://dx.doi.org/10.1177/1759091418782304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053578PMC
July 2019
10 Reads

Alternative Method to Detect Neuronal Degeneration and Amyloid β Accumulation in Free-Floating Brain Sections With Fluoro-Jade.

ASN Neuro 2018 Jan-Dec;10:1759091418784357

1 Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid (UCM), Spain.

Fluoro-Jade is a fluorescein-derived fluorochrome which specifically binds to damaged neurons. Due to this characteristic, it is commonly used for the histochemical detection and quantification of neurodegeneration in mounted brain sections. Here, we describe an alternative and simpler histochemistry protocol based on the use of free-floating brain sections. Read More

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http://dx.doi.org/10.1177/1759091418784357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043921PMC
July 2019
13 Reads

Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits.

ASN Neuro 2018 Jan-Dec;10:1759091418781921

1 Department of Anatomy and Neurobiology, University of California-Irvine, CA, USA.

An estimated 5.3 million Americans are living with a disability from a traumatic brain injury (TBI). There is emerging evidence of the detrimental effects from repeated mild TBIs (rmTBIs). Read More

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http://dx.doi.org/10.1177/1759091418781921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050992PMC
July 2019
26 Reads

Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson's Disease.

ASN Neuro 2018 Jan-Dec;10:1759091418781889

2 Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

Parkinson's disease (PD) is a neurodegenerative movement disorder involving the selective loss of dopamine-producing neurons in the substantia nigra (SN). Differences in disease presentation, prevalence, and age of onset have been reported between males and females with PD. The content and composition of the major glycosphingolipids, phospholipids, and cholesterol were evaluated in the SN from 12 PD subjects and in 18 age-matched, neurologically normal controls. Read More

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http://dx.doi.org/10.1177/1759091418781889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024349PMC
July 2019
2 Reads

Overexpression of CLEC18B Associates With the Proliferation, Migration, and Prognosis of Glioblastoma.

ASN Neuro 2018 Jan-Dec;10:1759091418781949

1 Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Henan, P.R. China.

C-type lectin domain family 18 member B (CLEC18B), encoding a superfamily of CLEC, has been found to be expressed in some of cancer cells, which possibly indicates it associated with cancer. However, the defined functional characterizations of CLEC18B in glioblastoma multiforme (GBM) progression still remain unclear. To this end, clinical relevance of CLEC18B expression with GBM patients' prognosis was analyzed both in The Cancer Genome Atlas dataset of 174 tissues and 40 GBM tumor tissues collected from our hospital by using the Kaplan-Meier survival and the Cox proportional hazard model. Read More

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http://dx.doi.org/10.1177/1759091418781949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024345PMC
July 2019
5 Reads

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment.

ASN Neuro 2018 Jan-Dec;10:1759091418777438

1 College of Life Sciences, Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, China.

Parkinson disease (PD) is the second most common neurodegenerative movement disorder. Pharmacological animal models are invaluable tools to study the pathological mechanisms of PD. Currently, invertebrate and vertebrate animal models have been developed by using several main neurotoxins, such as 6-hydroxydopamine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, paraquat, and rotenone. Read More

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http://dx.doi.org/10.1177/1759091418777438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977437PMC
July 2019
1 Read

In Vivo Optical Imaging of Myelination Events in a Myelin Basic Protein Promoter-Driven Luciferase Transgenic Mouse Model.

ASN Neuro 2018 Jan-Dec;10:1759091418777329

1 Translational In Vivo Model, Global Research Platform, Sanofi R&D, Framingham, MA, USA.

The compact myelin sheath is important for axonal function, and its loss can lead to neuronal cell death and irreversible functional deficits. Myelin is vulnerable to a variety of metabolic, toxic, and autoimmune insults. In diseases like multiple sclerosis, there is currently no therapy to stop myelin loss, underscoring the need for neuroprotective and remyelinating therapies. Read More

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http://dx.doi.org/10.1177/1759091418777329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987236PMC
July 2019
19 Reads

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway.

ASN Neuro 2018 Jan-Dec;10:1759091418775562

1 Department of Neurology, Keio University School of Medicine, Tokyo, Japan.

Oxidative stress plays an important role in the onset and progression of Parkinson disease. Although released dopamine at the synaptic terminal is mostly reabsorbed by dopaminergic neurons, some dopamine is presumably taken up by astroglia. This study examined the dopamine-induced astroglial protective function through the activation of the pentose-phosphate pathway (PPP) to reduce reactive oxygen species (ROS). Read More

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http://journals.sagepub.com/doi/10.1177/1759091418775562
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http://dx.doi.org/10.1177/1759091418775562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960859PMC
July 2019
18 Reads

Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats.

ASN Neuro 2018 Jan-Dec;10:1759091418770543

1 Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh, PA, USA.

Mild traumatic brain injury (mTBI) in children is a common and serious public health problem. Traditional neuroimaging findings in children who sustain mTBI are often normal, putting them at risk for repeated mTBI (rmTBI). There is a need for more sensitive imaging techniques capable of detecting subtle neurophysiological alterations after injury. Read More

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http://journals.sagepub.com/doi/10.1177/1759091418770543
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http://dx.doi.org/10.1177/1759091418770543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944144PMC
July 2019
12 Reads

Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation.

ASN Neuro 2018 Jan-Dec;10:1759091418766175

1 Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.

Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species methylglyoxal are implicated as a pathophysiology common to a wide variety of neurological diseases. Here, using an ex vivo nerve exposure model, we show that increasing methylglyoxal produces paranodal disruption, evidenced by disorganized immunostaining of axoglial cell-adhesion proteins, in both sciatic and optic nerves from wild-type mice. Read More

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http://dx.doi.org/10.1177/1759091418766175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944142PMC
July 2019
19 Reads