4,585 results match your criteria APMIS : acta pathologica microbiologica et immunologica Scandinavica[Journal]


Primary signet-ring stromal tumour of the testis: case report with literature review.

APMIS 2019 Jan;127(1):45-49

Institute of Pathology, University of Göttingen, Göttingen, Germany.

Primary signet-ring stromal tumour of the testis (PSRSTT) is a very rare type of primary testicular tumour, which is not actually mentioned in the current WHO categorization of tumours of the male genital organs. In this case we report about histologically and immunohistochemically features of this rare tumour. In the present case, PSRTT was found in the orchiectomy preparation of a 69-year-old man with painless swelling of his left testicle. Read More

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http://dx.doi.org/10.1111/apm.12907DOI Listing
January 2019
1 Read

The diabetic phenotype is preserved in myotubes established from type 2 diabetic subjects: a critical appraisal.

Authors:
Michael Gaster

APMIS 2019 Jan;127(1):3-26

Laboratory for Molecular Physiology, Department of Pathology and Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Cultured human myotubes offer a unique model to distinguish between primary and environmental factors in the aetiology of insulin resistance in human skeletal muscle. The objective of this review was to summarize our and other group studies on insulin resistance in human myotubes established from lean, obese and type 2 diabetes (T2D) subjects. Overall, studies of human myotubes established from lean, obese and T2D subjects clearly show that part of the diabetic phenotype observed in vivo is preserved in diabetic myotubes. Read More

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http://dx.doi.org/10.1111/apm.12908DOI Listing
January 2019

Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry.

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

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http://dx.doi.org/10.1111/apm.12900DOI Listing
January 2019

Comparison of methods for measuring antibiotic consumption in an intensive care unit.

APMIS 2019 Jan;127(1):33-40

Department of Neuroanaesthesiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Hospitals worldwide are working on minimizing unnecessary use of antimicrobials. To assess actual changes of antimicrobial usage, correct and precise measurements are necessary. This study aimed to compare data on the purchase of antibiotics from the pharmacy and the administration of antibiotics to patients, respectively, in an intensive care unit (ICU). Read More

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http://dx.doi.org/10.1111/apm.12909DOI Listing
January 2019

Human native endocarditis caused by Streptococcus canis-a case report.

APMIS 2019 Jan;127(1):41-44

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.

We report a very rare case of Streptococcus canis native infective endocarditis in a 73-year-old woman living in close contact with her dog. Her echocardiography showed large calcifications in the mitral annulus, massive regurgitation below the posterior leaflet, and adjacent vegetation. Blood culture was positive for Streptococcus Lancefield group G. Read More

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http://dx.doi.org/10.1111/apm.12905DOI Listing
January 2019
2 Reads

WHO laboratory validation of Xpert CT/NG and Xpert TV on the GeneXpert system verifies high performances.

APMIS 2018 Dec;126(12):907-912

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Effective tests for diagnosis of sexually transmitted infections (STIs), used point of care to inform treatment and management decisions, are urgently needed. We evaluated the analytical sensitivity and specificity of the Xpert CT/NG and Xpert TV tests, examining 339 samples spiked with phenotypically and/or genetically diverse strains of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis, and other related species that may cross-react. The APTIMA Combo 2 test and APTIMA TV test were used as reference tests. Read More

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http://doi.wiley.com/10.1111/apm.12902
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http://dx.doi.org/10.1111/apm.12902DOI Listing
December 2018
5 Reads

The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis.

APMIS 2018 Dec;126(12):885-891

Cystic Fibrosis Center Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Mycobacterium abscessus complex can cause severe lung infections and has proven to be a serious threat to patients with cystic fibrosis and a challenge for clinicians due to difficulties in timely diagnosis and complex multidrug treatment regimes. Mycobacterial culture is the gold standard for diagnosis, but in most cystic fibrosis centers it is performed less frequently than culture for other pathogens. Consensus today recommends just one annual mycobacterial culture for asymptomatic patients with cystic fibrosis, a strategy likely to lead to diagnostic delays. Read More

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http://dx.doi.org/10.1111/apm.12903DOI Listing
December 2018
4 Reads

Autotaxin and vascular endothelial growth factor receptor-2 and -3 are related to vascular development during the progression of chronic viral hepatitis C.

APMIS 2018 Dec;126(12):913-921

Organized Center of Clinical Medicine, International University of Health and Welfare, Tokyo, Japan.

Vascular endothelial growth factor (VEGF) and autotaxin (ATX) play important roles in embryonic vasculogenesis and cancer progression. This study examines whether these two angiogenic factors cooperate in the mechanism that regulates vascular development during the progression of chronic viral hepatitis C (CVH-C) (Inuyama classification, F1-F4). First, surgical wedge biopsy specimens and needle biopsy specimens were obtained. Read More

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http://doi.wiley.com/10.1111/apm.12904
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http://dx.doi.org/10.1111/apm.12904DOI Listing
December 2018
4 Reads

Early depletion of contact system in patients with sepsis: a prospective matched control observational study.

APMIS 2018 Dec 5;126(12):892-898. Epub 2018 Nov 5.

Department of Clinical Sciences Lund, Anaesthesiology and Intensive Care, Lund University, Skane University Hospital, Lund, Sweden.

Activation of the contact system generates bradykinin from high-molecular-weight kininogen and has been suggested to participate in the pathophysiology of sepsis. To test this, we prospectively measured bradykinin and high-molecular-weight kininogen levels in a cohort of sepsis patients requiring intensive care. From 29 patients meeting criteria for sepsis or septic shock according to Sepsis-3, blood was sampled within 24 h and on the fourth day following admittance to intensive care. Read More

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http://doi.wiley.com/10.1111/apm.12898
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http://dx.doi.org/10.1111/apm.12898DOI Listing
December 2018
4 Reads

Maternal and congenital cytomegalovirus infections in a population-based pregnancy cohort study.

APMIS 2018 Dec 30;126(12):899-906. Epub 2018 Oct 30.

Department of Microbiology, Oslo University Hospital, University of Oslo, Oslo, Norway.

CMV is the most common cause of congenital infection. During the past few decades, there has been a change in behaviour that possibly has affected the CMV infection rate of mother and child. We investigated 1350 randomly selected pregnant women from the Norwegian Mother and Child Cohort Study using an algorithm for detection of maternal and congenital CMV (cCMV) infection including both serology and nucleic acid amplification assay. Read More

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http://doi.wiley.com/10.1111/apm.12899
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http://dx.doi.org/10.1111/apm.12899DOI Listing
December 2018
4 Reads

Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.

APMIS 2018 Nov;126(11):852-863

Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

Pancreatic cancer arises from precursor lesions called pancreatic intraepithelial neoplasia (PanIN) characterized by inflammatory microenvironment. In pancreatic cancer, strong innate immunity and hypoxia responses are typical. Occurrence and relationship of these responses in human PanINs is unknown. Read More

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http://doi.wiley.com/10.1111/apm.12894
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http://dx.doi.org/10.1111/apm.12894DOI Listing
November 2018
5 Reads

Bartonella quintana, past, present, and future of the scourge of World War I.

Authors:
Joaquim Ruiz

APMIS 2018 Nov;126(11):831-837

Independent Researcher, Barcelona, Spain.

During World War I, a mysterious new disease affected soldiers on both sides of battle field. The first reports described a relapsing fever of unknown origin with body lice being suggested as the vector. The outbreak affected >1 000 000 people, mostly soldiers fighting in front-line trenches. Read More

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http://doi.wiley.com/10.1111/apm.12895
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http://dx.doi.org/10.1111/apm.12895DOI Listing
November 2018
6 Reads

Replicon typing of plasmids in environmental Achromobacter sp. producing quinolone-resistant determinants.

APMIS 2018 Nov;126(11):864-869

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, Brazil.

This study aimed to investigate the antimicrobial resistance profile to quinolones, the presence of quinolone-resistant determinants and the plasmid replicon typing in environmental Achromobacter sp. isolated from Brazil. Soil and water samples were used for bacterial isolation. Read More

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http://dx.doi.org/10.1111/apm.12896DOI Listing
November 2018

A fatal case of enterovirus infection with secondary hemophagocytosis-case report with review of literature.

APMIS 2018 Nov;126(11):877-882

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Enterovirus is a common viral infection, which can affect multiple organ systems with an array of clinical presentation such as meningitis, encephalitis, myocarditis, and disseminated infections. The illness is usually asymptomatic and self-limited but few cases can be severe and life-threatening especially when associated with hemophagocytosis. We discuss a fatal case of disseminated enterovirus infection and the histomorphological features of the infection. Read More

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http://doi.wiley.com/10.1111/apm.12892
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http://dx.doi.org/10.1111/apm.12892DOI Listing
November 2018
17 Reads
1.922 Impact Factor

Rapid antimicrobial susceptibility testing of positive blood cultures by direct inoculation and reading of disc diffusion tests after 3-4 hours.

APMIS 2018 Nov;126(11):870-876

Department of Medical Microbiology, Vestre Viken Hospital Trust, Drammen, Norway.

The aim of the study was to validate whether rapid antimicrobial susceptibility testing (AST) by very early reading of disc diffusion tests would provide reliable results in daily routine work. A total of 264 positive blood culture bottles were examined, of which 178 were examined as part of the daily routine workflow. Enterobacterales were evaluated for resistance to cefotaxime, ceftazidime, gentamicin and ampicillin. Read More

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http://doi.wiley.com/10.1111/apm.12897
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http://dx.doi.org/10.1111/apm.12897DOI Listing
November 2018
5 Reads

Prevalence of CYP2D6*4 1934G/A polymorphism in Western Indian HIV patients.

APMIS 2018 Nov;126(11):842-851

Department of Clinical Sciences, National AIDS Research Institute, Pune, India.

Hepatic CYP2D6 enzyme metabolizes antiretroviral drugs (ARVs) including nevirapine. Polymorphism in CYP2D6 gene affects drug metabolism and displays distinctive phenotypes in the population. Hence, we investigated the prevalence of CYP2D6*4 1934G/A polymorphism in a total of 165 HIV patients that include 34 with and 131 without hepatotoxicity and 160 unrelated healthy controls by the PCR-RFLP method. Read More

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http://doi.wiley.com/10.1111/apm.12893
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http://dx.doi.org/10.1111/apm.12893DOI Listing
November 2018
1 Read

Clinicopathological features of hydrophilic polymer emboli in Japanese autopsy cases.

APMIS 2018 Nov 15;126(11):838-841. Epub 2018 Oct 15.

Department of Pathology, Tokai University School of Medicine, Isehara, Japan.

Hydrophilic polymer is used on multiple endovascular devices to decrease friction between these devices and vessel walls. Although it can prevent medical device-related complications, hydrophilic polymer emboli (HPE) has recently been established as a potentially fatal iatrogenic phenomenon. HPE can cause tissue injury in numerous sites, including the brain, heart, lung, skin, and intestines. Read More

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http://doi.wiley.com/10.1111/apm.12891
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http://dx.doi.org/10.1111/apm.12891DOI Listing
November 2018
4 Reads

Medical and dental applications of nanomedicines.

APMIS 2018 Oct;126(10):795-803

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

Nanoparticles are tiny materials with nanosized components less than 100 nm in at least one dimension with physicochemical properties, which make them very attractive for medical application. These compounds have been evaluated as potential medicines for several decades. Nanotechnology has provided advances in the various fields of health sciences such as diagnosis, prevention and treatment by application of the agents named nanomedicines, including proteins, polymers, micelles, dendrimers, liposomes, emulsions, nanocapsules and nanoparticles. Read More

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http://dx.doi.org/10.1111/apm.12890DOI Listing
October 2018
6 Reads

Tumor microenvironmental factors have prognostic significances in advanced gastric cancer.

APMIS 2018 Oct;126(10):814-821

Department of Pathology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.

Tumor microenvironment is important in the progression and survival of cancer cells. We evaluated the prognostic significance of tumor stroma percentage (TSP), Klintrup-Mäkinen (KM) grade, which reflects the density of inflammatory cells of the tumor, and Glasgow microenvironment score (GMS), a combination of TSP and KM grade, in advanced gastric cancers. A total of 196 pT3 and pT4 gastric cancers were histologically evaluated using TSP, KM grade, and GMS. Read More

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http://doi.wiley.com/10.1111/apm.12889
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http://dx.doi.org/10.1111/apm.12889DOI Listing
October 2018
7 Reads

Predictive value of combined analysis of pro-NPY and ERG in localized prostate cancer.

APMIS 2018 Oct 6;126(10):804-813. Epub 2018 Sep 6.

Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

This study aimed to investigate if combined analysis of pro-Neuropeptide Y (NPY) and ERG expression in tumor tissue are associated with biochemical failure (BF), castration-based treatment, castration-resistant prostate cancer (CRPC), and prostate cancer (PCa)-specific death for men undergoing radical prostatectomy (RP) for PCa. This study included 315 patients, who underwent RP from 2002 to 2005. Both pro-NPY and ERG expression were analyzed using immunohistochemistry and were scored as low or high and negative or positive, respectively. Read More

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http://dx.doi.org/10.1111/apm.12886DOI Listing
October 2018

Performance characteristics of newer MIC gradient strip tests compared with the Etest for antimicrobial susceptibility testing of Neisseria gonorrhoeae.

APMIS 2018 Oct 6;126(10):822-827. Epub 2018 Sep 6.

WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

For Neisseria gonorrhoeae susceptibility testing, Etest, comparable to agar dilution, is frequently used. In recent years, newer MIC gradient strip tests have been commercialized. However, these tests have not been appropriately evaluated for gonococci. Read More

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http://doi.wiley.com/10.1111/apm.12887
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http://dx.doi.org/10.1111/apm.12887DOI Listing
October 2018
6 Reads
1.920 Impact Factor

The use of fluorescent staining techniques for microscopic investigation of polymorphonuclear leukocytes and bacteria.

APMIS 2018 Oct 6;126(10):779-794. Epub 2018 Sep 6.

Costerton Biofilm Center, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

The use of fluorescent stains to visually investigate eukaryotic and/or prokaryotic cells is increasing quickly and manuscripts within all areas of research publish results using fluorescent staining techniques. However, in contrast to literature on traditional histological staining techniques, the literature on fluorescent stains and staining techniques does not offer as good an illustration of cellular morphology. The aim of this guideline is to illustrate different fluorescent stains and staining techniques for imaging immune cells, in particular the polymorphonuclear leukocytes (PMNs), in combination with infecting bacteria as seen in chronic bacterial infections. Read More

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http://doi.wiley.com/10.1111/apm.12888
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http://dx.doi.org/10.1111/apm.12888DOI Listing
October 2018
4 Reads

Evaluation of the gastrointestinal tract in mdx mice: an experimental model of Duchenne muscular dystrophy.

APMIS 2018 Aug;126(8):693-699

Pharmacology Department, Faculdade de Medicina do ABC, Santo André, SP, Brazil.

This study describes the functional and morphological alterations in the intestines of mdx mice (n = 4) compared with the intestinal features of C57BL/10 mice (n = 7) at 2 months of age. The whole gut transit time (carmine red) and the upper gut transit time (activated charcoal) were measured, and light microscopy was utilized to view stained sections (H&E and picrosirius red) for histological analysis. No significant difference in mean evacuation time for the whole gut was observed between the two groups, but a significant delay in activated charcoal passage was observed in the mdx mice. Read More

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http://doi.wiley.com/10.1111/apm.12864
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http://dx.doi.org/10.1111/apm.12864DOI Listing
August 2018
6 Reads

Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner.

APMIS 2018 Aug;126(8):667-677

Department of Medical Sciences, Örebro University, Örebro, Sweden.

Strong epidemiological evidence supports an association between cardiovascular and periodontal disease and furthermore, the periodontopathogen Porphyromonas gingivalis has been identified in blood and from atheromatous plaques. Blood exposed to P. gingivalis shows an increased protein modification of low-density lipoprotein (LDL). Read More

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http://dx.doi.org/10.1111/apm.12860DOI Listing

Staphylococcus epidermidis from prosthetic joint infections induces lower IL-1β release from human neutrophils than isolates from normal flora.

APMIS 2018 Aug;126(8):678-684

School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

The aim of this study was to test the hypothesis that Staphylococcus epidermidis isolated from prosthetic joint infections (PJIs) differs from S. epidermidis isolated from normal flora in terms of its capacity to induce activation of caspase-1 and release of IL-1β in human neutrophils. The amount of active caspase-1 was determined over 6 h by detecting Ac-YVAD-AMC fluorescence in human neutrophils incubated with S. Read More

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http://dx.doi.org/10.1111/apm.12861DOI Listing
August 2018
6 Reads

Patient characteristics of olfactory neuroblastoma: experience from a tertiary cancer centre 2000-2016 covering Eastern Denmark.

APMIS 2018 Aug;126(8):663-666

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark.

The aim of this study was to report incidence and patient characteristics of olfactory neuroblastoma (ONB) at a tertiary cancer institution during a 16-year period. A retrospective review was conducted on patients with ONB treated at Rigshospitalet, Copenhagen from 2000 to 2016 covering Eastern Denmark. Patient demographics, symptoms, stage, pathology-reports, treatment, and outcome were extracted from the patient records and the Danish pathology register. Read More

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http://dx.doi.org/10.1111/apm.12859DOI Listing
August 2018
7 Reads

Detection of extended-spectrum beta-lactamase production in Enterobacteriales from patients with suspected urinary tract infections, Tabora region, Rural Tanzania.

APMIS 2018 08;126(8):700-702

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, Örebro, Sweden.

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http://dx.doi.org/10.1111/apm.12863DOI Listing

Primary and secondary mucosal melanoma of the small intestine - a clinical, pathological, and genetic nationwide survey of Danish patients between 1980 and 2014.

APMIS 2018 Sep;126(9):739-745

Department of Pathology, Rigshospitalet, Copenhagen, Denmark.

The aim of this study was to describe the epidemiology, symptomatology, pathology, genetics, and treatment of primary and metastatic small intestine melanoma in a national Danish cohort. All Danish patients diagnosed with small intestinal melanoma during the period 1980-2014 were included. For each patient, clinical data along with available pathology report and tissue was registered. Read More

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http://doi.wiley.com/10.1111/apm.12883
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http://dx.doi.org/10.1111/apm.12883DOI Listing
September 2018
8 Reads

Hypochromatic large urothelial cells in urine cytology are indicative of high grade urothelial carcinoma.

APMIS 2018 Sep;126(9):705-709

Faculty of Medicine, Unit of Anatomical Pathology, Cordoba University, Cordoba, Spain.

In this study, we have examined 67 cytology specimens from patients from 2014 to 2016. The ratio man to women was 4:1 with a median age of 75 years (range: 55-87 years). Thin-Prep processed urinary cytology specimens demonstrated large urothelial cells, with cytologic features of malignancy, thus including hypochromatic nuclei with occasional peripherally accentuated chromatin rim. Read More

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http://dx.doi.org/10.1111/apm.12877DOI Listing
September 2018
1 Read

Stability of oestrogen and progesterone receptor antigenicity in formalin-fixed paraffin-embedded breast cancer tissue over time.

APMIS 2018 Sep;126(9):746-754

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.

Use of archived formalin-fixed paraffin-embedded (FFPE) tissue is a standard method for evaluation of proposed prognostic and predictive tumour markers. However, little is known of the preservation of biomarker expression in old FFPE tumour blocks. We investigate the quality of immunohistochemical (IHC) oestrogen (ER) and progesterone receptor (PR) evaluation in FFPE tissue over time (1978-2000) using a large breast cancer tissue microarray (N = 573) with access to receptor analyses in cytosol (CYT) at diagnosis, coexpression of other biomarkers and follow-up data. Read More

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http://dx.doi.org/10.1111/apm.12884DOI Listing
September 2018
11 Reads
1.920 Impact Factor

Increased levels of serum miR-148a-3p are associated with prostate cancer.

APMIS 2018 Sep;126(9):722-731

St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Prostate cancer (PCa) is one of the most common types of cancer and the fifth leading cause of death among men worldwide. The tools for diagnosing PCa have limited value, and to improve correct diagnosis there is a need for markers that can contribute to a more precise diagnosis, which would lead to proper treatment of only those patients who need it. Micro RNA (miRNA) plays a key role in the development of cancer and is therefore a potential marker for PCa. Read More

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http://dx.doi.org/10.1111/apm.12880DOI Listing
September 2018
9 Reads

Vascular adhesion protein-1 as indicator of breast cancer tumor aggressiveness and invasiveness.

APMIS 2018 Sep;126(9):755-761

Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Recent studies suggest that vascular adhesion protein-1 (VAP-1), a 180-KDa homodimeric glycoprotein, may be associated with cancer-related events including tumor cell migration, motility, invasion, or metastasis. Therefore, this study applies VAP-1 immunohistochemical staining to demonstrate the invasiveness component of the breast cancer. The VAP-1 staining results were compared in 148 breast cancer cases to identify possible correlations with clinical status, including age, tumor size, tumor grade, TNM stage, lymphatic invasion, metastasis, recurrence, and survival rate. Read More

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http://dx.doi.org/10.1111/apm.12885DOI Listing
September 2018
1 Read

CD8+ and CD163+ infiltrating cells and PD-L1 immunoexpression in oral leukoplakia and oral carcinoma.

APMIS 2018 Sep;126(9):732-738

Department of Pathomorphology, Medical University of Lodz, Lodz, Poland.

Overexpression of inhibitory checkpoint PD1/PD-L1 plays an important role in carcinogenesis and patients prognosis. 70 cases of oral squamous cell carcinoma (OSCC), 23 cases of oral leukoplakia (OLK), and 19 control cases were immunohistochemically stained with anti-PD-L1, -CD8, and -CD163 antibodies. PD-L1 was expressed on dysplastic and subepithelial infiltrating cells of OLK as well as on cancer and tumor-infiltrating cells of OSCC. Read More

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http://doi.wiley.com/10.1111/apm.12881
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http://dx.doi.org/10.1111/apm.12881DOI Listing
September 2018
14 Reads

Survival of Campylobacter jejuni and Campylobacter coli water isolates in lake and well water.

APMIS 2018 Sep;126(9):762-770

Department of Medical Sciences, Clinical Microbiology, Uppsala University, Uppsala, Sweden.

The role of water for transmission of Campylobacter jejuni and C. coli to humans might be underestimated, as factors important for bacterial viability in water are largely unknown. We have studied water survival of seven C. Read More

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http://dx.doi.org/10.1111/apm.12879DOI Listing
September 2018
1 Read

Unicystic high-grade intraductal carcinoma of the parotid gland: cytological and histological description with clinic-pathologic review of the literature.

APMIS 2018 Sep;126(9):771-776

Laboratory of Pathology, Department of Translational Medicine, UPO School of Medicine, Novara, Italy.

Intraductal carcinoma of the salivary glands is a rare, not well-characterized tumor. We reviewed the literature and report the first case of a high-grade unicystic intraductal carcinoma of the parotid. Formalin-fixed/paraffin-embedded blocks were sectioned and stained for hematoxylin and eosin and immunostains (CAM5. Read More

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http://doi.wiley.com/10.1111/apm.12882
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http://dx.doi.org/10.1111/apm.12882DOI Listing
September 2018
10 Reads

APMIS special issue - Placental Pathology.

APMIS 2018 07;126(7):543

Perinatal and Paediatric Pathology, Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/apm.12857DOI Listing
July 2018
1 Read

The structure and utility of the placental pathology report.

APMIS 2018 Jul;126(7):638-646

Faculty of Biological, Medical and Human Sciences, School of Medical Sciences, Maternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.

The placenta is one of the most exciting organs. It is dynamic; its morphology and function continuously develop and adjust over its brief life span. It mediates the physiology of two distinct yet highly interconnected individuals. Read More

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http://dx.doi.org/10.1111/apm.12842DOI Listing
July 2018
11 Reads

Abnormalities of placenta implantation.

APMIS 2018 Jul;126(7):613-620

Department of Pathology and Immunology, Texas Children's Hospital, Pavilion for Women, Baylor College of Medicine, Houston, TX, USA.

Implantation abnormalities are a group of disorders encompassing several entities with different degree of severity. This section will cover the etiopathogenesis, imaging findings, definition, risk factors, and pathology of the abnormally located and morbidly adherent placenta. Read More

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http://dx.doi.org/10.1111/apm.12831DOI Listing
July 2018
1 Read

Histopathological examination of the placenta in twin pregnancies.

APMIS 2018 Jul;126(7):626-637

Department of Pathology, Cork University Hospital, Cork, Ireland.

Twin placentas are frequently received in pathology laboratories for evaluation of chorionicity and because twin pregnancies have higher rates of pregnancy complications. In addition to pathologies common in singleton pregnancies, twin pregnancies have increased frequencies of complications such as preterm birth and velamentous cord insertions and also are affected by complications unique to multiple pregnancies that are mediated by vascular connections between the placental territories of certain types of twins. This article aims to provide an approach to examination of the twin placenta for practicing pathologists or those interested in placental pathology while outlining the key characteristics of twin complications as seen in the placenta. Read More

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http://dx.doi.org/10.1111/apm.12829DOI Listing
July 2018
10 Reads

Re-view and view on maturation disorders in the placenta.

APMIS 2018 Jul;126(7):602-612

Department of Pathology, Charité - Universitätsmedizin, Berlin, Germany.

Until delivery, the placenta plays an important mediator role between mother and fetus. This unit is affected by peristatic conditions, such as acute or chronic maternal diseases, malnutrition, drugs, and others. But also genetic factors and fetal malformations due to embryonic developmental disorders may contribute to macroscopically visible changes and functional disorders of the placenta. Read More

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http://dx.doi.org/10.1111/apm.12858DOI Listing
July 2018
1 Read

Defense and infection of the human placenta.

APMIS 2018 Jul;126(7):570-588

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

The placenta functions as a shield against infection of the fetus. The innate and adaptive immune defenses of the developing fetus are poorly equipped to fight infections. Infection by bacteria, viruses, and protozoa may cause infertility, spontaneous abortion, stillbirth, growth retardation, anomalies of development, premature delivery, neonatal morbidity, and mortality. Read More

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http://dx.doi.org/10.1111/apm.12847DOI Listing
July 2018
14 Reads

The placenta in intrauterine demise.

Authors:
Theonia K Boyd

APMIS 2018 Jul;126(7):621-625

Boston Children's Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Placental changes in intrauterine demise can be similar to antemortem pathologic processes. This chapter provides an overview of postmortem placental changes, and provides an algorithmic set of considerations for discriminating between ante- and postmortem pathology. Read More

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http://dx.doi.org/10.1111/apm.12832DOI Listing
July 2018
3 Reads

Maternal vascular malperfusion of the placental bed.

Authors:
Linda M Ernst

APMIS 2018 Jul;126(7):551-560

Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston Hospital, Evanston, IL, USA.

Maternal vascular malperfusion (MVM) of the placental bed represents a recognizable pattern of placental injury related to altered uterine and intervillous blood flow. MVM consists of a constellation of placental pathologic findings seen in the maternal decidual vessels, reflecting abnormal spiral artery remodeling, as well as in the villous parenchyma, reflecting abnormalities in oxygenation and flow dynamics in the intervillous space. This review is dedicated to the gross pathology, microscopic pathology, updated terminology, and clinical implications of MVM. Read More

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http://dx.doi.org/10.1111/apm.12833DOI Listing
July 2018
1 Read

Update on the pathology of gestational trophoblastic disease.

Authors:
Debra S Heller

APMIS 2018 Jul;126(7):647-654

Department of Pathology & Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Gestational trophoblastic disease can be a challenging area for pathologic evaluation. An update with a focus on pathologic challenges is presented. Read More

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http://doi.wiley.com/10.1111/apm.12786
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http://dx.doi.org/10.1111/apm.12786DOI Listing
July 2018
17 Reads

Fetal vascular malperfusion, an update.

APMIS 2018 Jul;126(7):561-569

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Read More

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http://dx.doi.org/10.1111/apm.12849DOI Listing
July 2018
3 Reads

Indications for submission and macroscopic examination of the placenta.

APMIS 2018 Jul;126(7):544-550

Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.

The placenta is a fetal organ, composed of fetal DNA and as such reflects the fetal phenotype. The placenta consists of an umbilical cord, fetal membranes (amnion and chorion), and the placental disc which in turn is comprised of villous tissue. Both maternal and fetal disorders have placental sequelae and placental abnormalities can affect both maternal and fetal well-being. Read More

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http://doi.wiley.com/10.1111/apm.12830
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http://dx.doi.org/10.1111/apm.12830DOI Listing
July 2018
10 Reads

Hepatoprotectivity of Panduratin A against liver damage: In vivo demonstration with a rat model of cirrhosis induced by thioacetamide.

APMIS 2018 Sep 29;126(9):710-721. Epub 2018 Jul 29.

Biophysics Department, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

This experiment evaluated Panduratin A (PA), a chalcone isolated from Boesenbergia rotunda rhizomes, for its hepatoprotectivity. Rats were subjected to liver damage induced by intra-peritoneal injection of thioacetamide (TAA). PA was tested first for its acute toxicity and then administered by oral gavage at doses 5, 10, and 50 mg/kg to rats. Read More

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http://dx.doi.org/10.1111/apm.12878DOI Listing
September 2018
8 Reads
1.922 Impact Factor

Implants induce a new niche for microbiomes.

APMIS 2018 Aug 2;126(8):685-692. Epub 2018 Jul 2.

Costerton Biofilm Center, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark.

Although much work is being done to develop new treatments, research and knowledge regarding factors underlying implant-related microbial colonization leading to infection are less comprehensive. Presence of microorganisms in and around implants clinically characterized as uninfected remains unknown. The objective of this study was to detect and identify bacteria and fungi on implants from various groups of patients with no prior indications of implant related infections. Read More

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http://dx.doi.org/10.1111/apm.12862DOI Listing
August 2018
8 Reads

IgG4-related disease: review of the histopathologic features, differential diagnosis, and therapeutic approach.

APMIS 2018 Jun;126(6):459-476

The James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Boston, MA, USA.

Immunoglobulin G4-related disease (IgG4-RD) is an uncommon disorder that demonstrates characteristic clinicopathologic features including sclerosing lesions with storiform fibrosis, increased IgG4+ plasma cells with an increased IgG4+/IgG+ plasma cell ratio, obliterative phlebitis, and often an increased serum IgG4 level. This review summarizes the characteristic histopathologic and clinical features of IgG4-RD with detailed discussion of the histopathologic characteristics of the most commonly involved anatomic sites. We also present recent advances in our understanding of the pathophysiologic mechanisms of IgG4-RD and discuss updates on the treatment, prognosis, and outcomes of this rare disease, including discussion of the possible association between IgG4-RD and malignancy. Read More

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http://dx.doi.org/10.1111/apm.12845DOI Listing
June 2018
10 Reads

Prognostic impact of doublecortin-like kinase 1 expression in locally advanced rectal cancer treated with preoperative chemoradiotherapy.

APMIS 2018 Jun;126(6):486-493

Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Preoperative chemoradiotherapy (CRT) is a standard therapy for locally advanced rectal cancer; however, the response varies depending on cases. Therefore, CRT-response predictors need to be elucidated. Cancer stem cells (CSCs), comprising a small part of tumors, are associated with tumor progression and recurrence due to their self-renewal and proliferation abilities. Read More

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http://dx.doi.org/10.1111/apm.12852DOI Listing
June 2018
10 Reads