A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation.
- Freia F Schmid,
- Florian Groeber-Becker,
- Stefanie Schwab,
- Sibylle Thude,
- Heike Walles,
- Jan Hansmann
ALTEX 2018 Apr 13. Epub 2018 Apr 13.
Translational Center Regenerative Therapies, Fraunhofer Institute for Silicate Research, Würzburg, Germany.
To protect the human skin from extensive solar radiation, melanocytes produce melanin and disperse it via melanosomes to keratinocytes in the basal and suprabasal layers of the human epidermis. Moreover, melanocytes are associated with pathological skin conditions such as vitiligo and psoriasis. Thus, an in vitro skin model that comprises a defined cutaneous pigmentation system is highly relevant in cosmetic, pharmaceutical and medical research. Read More