ALTEX 2017 Dec 2. Epub 2017 Dec 2.
Human and Environmental Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany.
The proximal tubule is the primary site for renal solute reabsorption and secretion and thus a main target for drug-induced toxicity. Current nonclinical methods using 2D cell cultures are unable to fully recapitulate clinical drug responses mainly due to limited in vitro functional lifespan. Since extracellular matrices are known to be key regulators of cell development, culturing cells on classic 2D plastic surfaces inevitably results in loss of differentiation. Read More