1,019 results match your criteria AJS; American journal of sociology[Journal]


Anterior joint space narrowing in patients with temporomandibular disorder.

J Orofac Orthop 2019 Apr 4. Epub 2019 Apr 4.

Department of Orthodontics, Seoul National University Dental Hospital, 101 Daehak-ro, Jongno-Gu, 03080, Seoul, South Korea.

Purpose: The aim of this work is to investigate changes in the anterior joint space (AJS) and the relationship of such changes to clinical symptoms in chronic temporomandibular joint disorder (TMD) patients, and to compare symptoms between chronic and acute TMD patients.

Methods: Data from 100 TMD patients diagnosed based on the Diagnostic Criteria for Temporomandibular Disorders (55 women; mean age 34.34 ± 14. Read More

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http://dx.doi.org/10.1007/s00056-019-00172-yDOI Listing
April 2019
3 Reads

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism.

J Cell Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Pharmacology and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL

Vascular endothelial (VE) protein tyrosine phosphatase (PTP) is an endothelial-specific phosphatase that stabilizes VE-cadherin junctions. Although studies have focused on the role of VE-PTP in dephosphorylating VE-cadherin in the activated endothelium, little is known of VE-PTP's role in the quiescent endothelial monolayer. Here, we used the photoconvertible fluorescent protein VE-cadherin-Dendra2 to monitor VE-cadherin dynamics at adherens junctions (AJs) in confluent endothelial monolayers. Read More

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http://dx.doi.org/10.1083/jcb.201807210DOI Listing

Management of acute upper gastrointestinal bleeding.

BMJ 2019 Mar 25;364:l536. Epub 2019 Mar 25.

Section of Digestive Diseases, Yale School of Medicine, New Haven, and VA Connecticut Healthcare System, West Haven, Connecticut, CT 06520, USA.

Upper gastrointestinal bleeding (UGIB) is a common medical emergency, with a reported mortality of 2-10%. Patients identified as being at very low risk of either needing an intervention or death can be managed as outpatients. For all other patients, intravenous fluids as needed for resuscitation and red cell transfusion at a hemoglobin threshold of 70-80 g/L are recommended. Read More

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http://www.bmj.com/lookup/doi/10.1136/bmj.l536
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http://dx.doi.org/10.1136/bmj.l536DOI Listing
March 2019
2 Reads

Role of adherens junctions and apical-basal polarity of neural stem/progenitor cells in the pathogenesis of neurodevelopmental disorders: a novel perspective on congenital Zika syndrome.

Transl Res 2019 Mar 5. Epub 2019 Mar 5.

Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia Chile; Centro de Investigación Biomédica (CIB), Facultad de Medicina, Universidad de los Andes, Santiago, Chile. Electronic address:

Radial glial cells (RGCs) are the neural stem/progenitor cells (NSPCs) that give rise to most of neurons and glial cells that constitute the adult central nervous system. A hallmark of RGCs is their polarization along the apical-basal axis. They extend a long basal process that contacts the pial surface and a short apical process to the ventricular surface. Read More

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http://dx.doi.org/10.1016/j.trsl.2019.02.014DOI Listing
March 2019
2 Reads

Differential Proteomics Reveals miR-155 as a Novel Indicator of Liver and Spleen Pathology in the Symptomatic Niemann-Pick Disease, Type C1 Mouse Model.

Molecules 2019 Mar 12;24(5). Epub 2019 Mar 12.

Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.

Niemann-Pick disease, type C1 (NPC1) is a rare, autosomal recessive, lipid storage disorder caused by mutations in . As a result, there is accumulation of unesterified cholesterol and sphingolipids in the late endosomal/lysosomal system. Clinically, patients can present with splenomegaly and hepatomegaly. Read More

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http://dx.doi.org/10.3390/molecules24050994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429457PMC
March 2019
1 Read

E-cadherin expression pattern during zebrafish embryonic epidermis development.

F1000Res 2018 18;7:1489. Epub 2018 Sep 18.

Laboratorio de Microscopía Aplicada a Estudios Moleculares y Celulares (LAMAE), Facultad de Ingeniería, Universidad Nacional de Entre Ríos, Oro Verde, 3100, Argentina.

: E-cadherin is the major adhesion receptor in epithelial adherens junctions (AJs). On established epidermis, E-cadherin performs fine-tuned cell-cell contact remodeling to maintain tissue integrity, which is characterized by modulation of cell shape, size and packing density. In zebrafish, the organization and distribution of E-cadherin in AJs during embryonic epidermis development remain scarcely described. Read More

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http://dx.doi.org/10.12688/f1000research.15932.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234749.3PMC
September 2018
1 Read

Oral Mucosal Epithelial Cells.

Front Immunol 2019 14;10:208. Epub 2019 Feb 14.

Department of Periodontology, Justus-Liebig-University of Giessen, Giessen, Germany.

The function of epithelial tissues is the protection of the organism from chemical, microbial, and physical challenges which is indispensable for viability. To fulfill this task, oral epithelial cells follow a strongly regulated scheme of differentiation that results in the formation of structural proteins that manage the integrity of epithelial tissues and operate as a barrier. Oral epithelial cells are connected by various transmembrane proteins with specialized structures and functions. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383680PMC
February 2019
4 Reads

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.

Front Physiol 2018 23;9:1942. Epub 2019 Jan 23.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.

The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions (TJ), adherens junctions (AJ), and desmosomes with unique cellular functions and a complex molecular composition. These proteins mediate firm mechanical stability, serves as a gatekeeper for the paracellular pathway, and helps in preserving tissue homeostasis. Read More

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http://dx.doi.org/10.3389/fphys.2018.01942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351700PMC
January 2019
4 Reads

The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling.

Cell Rep 2019 Jan;26(3):670-688.e6

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

Hippo signaling and the activity of its transcriptional coactivator, Yorkie (Yki), are conserved and crucial regulators of tissue homeostasis. In the Drosophila midgut, after tissue damage, Yki activity increases to stimulate stem cell proliferation, but how Yki activity is turned off once the tissue is repaired is unknown. From an RNAi screen, we identified the septate junction (SJ) protein tetraspanin 2A (Tsp2A) as a tumor suppressor. Read More

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http://dx.doi.org/10.1016/j.celrep.2018.12.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394833PMC
January 2019
1 Read

The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics.

J Cell Sci 2019 Feb 11;132(3). Epub 2019 Feb 11.

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA

The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects the actomyosin networks of neighboring cardiomyocytes and is required for proper heart function. Yet little is known about the molecular composition of the cardiomyocyte AJ or how it is organized to function under mechanical load. Read More

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.221606
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http://dx.doi.org/10.1242/jcs.221606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382013PMC
February 2019
7 Reads
5.432 Impact Factor

Loss of Lgl1 Disrupts the Radial Glial Fiber-guided Cortical Neuronal Migration and Causes Subcortical Band Heterotopia in Mice.

Neuroscience 2019 Feb 28;400:132-145. Epub 2018 Dec 28.

School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China. Electronic address:

Radial glial cells (RGCs) are neuronal progenitors and function as scaffolds for neuronal radial migration in the developing cerebral cortex. These functions depend on a polarized radial glial scaffold, which is of fundamental importance for brain development. Lethal giant larvae 1 (Lgl1), a key regulator for cell polarity from Drosophila to mammals, plays a key role in tumorigenesis and brain development. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2018.12.039DOI Listing
February 2019

β-Catenin phosphorylation at Y654 and Y142 is crucial for high mobility group box-1 protein-induced pulmonary vascular hyperpermeability.

J Mol Cell Cardiol 2019 Feb 25;127:174-184. Epub 2018 Dec 25.

Department of Pathophysiology, Key Laboratory for Shock and Microcirculation Research of Guangdong Province, Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou 510515, China. Electronic address:

Objective: Endothelial hyperpermeability is a hallmark of acute lung injury in response to sepsis. The imbalance between adherence junction (AJ) mediated cell-cell adherence forces and stress fiber driven contractile forces contributes to increased endothelial permeability. Here, we spotlight the effects of β-catenin Y654 andY142 phosphorylation on HMGB1-mediated endothelial barrier leakage. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2018.12.012DOI Listing
February 2019
2 Reads

Striatin is a novel modulator of cell adhesion.

FASEB J 2019 Apr 28;33(4):4729-4740. Epub 2018 Dec 28.

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

The adherens junctions (AJs) and tight junctions (TJs) provide critical adhesive contacts between neighboring epithelial cells and are crucial for epithelial adhesion, integrity, and barrier functions in a wide variety of tissues and organisms. The striatin protein family, which are part of the striatin interaction phosphatases and kinases complex, are multidomain scaffolding proteins that play important biologic roles. We have previously shown that striatin colocalizes with the tumor suppressor protein adenomatous polyposis coli in the TJs of epithelial cells. Read More

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http://dx.doi.org/10.1096/fj.201801882RDOI Listing
April 2019
4 Reads

The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.

Cell Tissue Res 2019 Feb 27;375(2):451-482. Epub 2018 Dec 27.

Helmholtz Group for Cell Biology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

The testes of sexually mature males of six mammalian species (men, bulls, boars, rats, mice, guinea pigs) have been studied using biochemical as well as light and electron microscopical techniques, in particular immunolocalizations. In these tissues, the peritubular walls represent lamellar encasement structures wrapped around the seminiferous tubules as a bandage system of extracellular matrix layers, alternating with monolayers of very flat polyhedral "lamellar smooth muscle cells" (LSMCs), the number of which varies in different species from 1 to 5 or 6. These LSMCs are complete SMCs containing smooth muscle α-actin (SMA), myosin light and heavy chains, α-actinin, tropomyosin, smoothelin, intermediate-sized filament proteins desmin and/or vimentin, filamin, talin, dystrophin, caldesmon, calponin, and protein SM22α, often also cytokeratins 8 and 18. Read More

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http://dx.doi.org/10.1007/s00441-018-2968-xDOI Listing
February 2019
1 Read

CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion.

Sci Rep 2018 Dec 7;8(1):17705. Epub 2018 Dec 7.

National Research Council, Institute of Cell Biology and Neurobiology - Campus Adriano Buzzati-Traverso Via E. Ramarini, 32 00015, Monterotondo (Rome), Italy.

Inflammatory caspases, including human caspase-4 (CASP4), play key roles in innate immune responses to promote fusion of phagosomes harboring pathogenic bacteria with lysosomes, halt intracellular replication of pathogens, maturation and secretion of pro-inflammatory cytokines. The role of inflammatory caspases in cancer cells remains poorly investigated. Here, we explored the consequences of modulating CASP4 expression levels on the migratory behavior of epithelial cancer cell lines. Read More

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http://www.nature.com/articles/s41598-018-35792-8
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http://dx.doi.org/10.1038/s41598-018-35792-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286322PMC
December 2018
18 Reads

Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study.

BMJ 2018 12 5;363:k4764. Epub 2018 Dec 5.

Harvard Medical School, Boston, MA, USA.

Objective: To determine whether medical errors, family experience, and communication processes improved after implementation of an intervention to standardize the structure of healthcare provider-family communication on family centered rounds.

Design: Prospective, multicenter before and after intervention study.

Setting: Pediatric inpatient units in seven North American hospitals, 17 December 2014 to 3 January 2017. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278585PMC
http://dx.doi.org/10.1136/bmj.k4764DOI Listing
December 2018
16 Reads

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions.

Nat Commun 2018 11 30;9(1):5121. Epub 2018 Nov 30.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.

α-catenin is a key mechanosensor that forms force-dependent interactions with F-actin, thereby coupling the cadherin-catenin complex to the actin cytoskeleton at adherens junctions (AJs). However, the molecular mechanisms by which α-catenin engages F-actin under tension remained elusive. Here we show that the α1-helix of the α-catenin actin-binding domain (αcat-ABD) is a mechanosensing motif that regulates tension-dependent F-actin binding and bundling. Read More

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http://dx.doi.org/10.1038/s41467-018-07481-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269467PMC
November 2018
1 Read

Time to onset and time to resolution of extrapyramidal symptoms in patients with exacerbated schizophrenia treated with 3-monthly vs once-monthly paliperidone palmitate.

Neuropsychiatr Dis Treat 2018 25;14:2807-2816. Epub 2018 Oct 25.

Janssen Research and Development, LLC, Titusville, NJ, USA,

Objective: The aim of this study was to evaluate the safety of 3-monthly paliperidone palmitate (PP3M) vs once-monthly paliperidone palmitate (PP1M) treatment with regard to extrapyramidal symptom (EPS)-related treatment-emergent adverse events (TEAEs) in patients with schizophrenia, previously stabilized on PP1M treatment.

Patients And Methods: Data on overall incidence, time to onset (TTO), and time to resolution (TTR) of EPS-related TEAEs (overall, subclasses such as dyskinesia, dystonia, hyperkinesia, parkinsonism, and tremor) from a randomized double-blind (DB) non-inferiority study were compared between PP3M and PP1M. Subgroup analysis was performed by age (18-25, 26-50, and 50+ years) and final open-label (OL) dose (50/75, 100, and 150 mg eq. Read More

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http://dx.doi.org/10.2147/NDT.S175364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207222PMC
October 2018
2 Reads

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

J Cell Biol 2019 Jan 21;218(1):299-316. Epub 2018 Nov 21.

Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL

Vascular endothelial (VE)-cadherin forms homotypic adherens junctions (AJs) in the endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells and surrounding vascular smooth muscle cells and pericytes. Here we addressed the question whether both cadherin adhesion complexes communicate through intracellular signaling and contribute to the integrity of the endothelial barrier. We demonstrated that deletion of N-cadherin () in either endothelial cells or pericytes increases junctional endothelial permeability in lung and brain secondary to reduced accumulation of VE-cadherin at AJs. Read More

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http://dx.doi.org/10.1083/jcb.201802076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314553PMC
January 2019
28 Reads

Knockdown of P120 catenin aggravates endothelial injury under an impinging flow by inducing breakdown of adherens junctions.

Mol Med Rep 2019 Jan 13;19(1):541-548. Epub 2018 Nov 13.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China.

At present, the mechanisms underlying intracranial aneurysm (IA) development remain unclear; however, hemodynamics is considered a crucial factor in the induction of IA. To elucidate the association between hemodynamics and endothelial cell (EC) functions, a modified T chamber system was designed to simulate the adjustable hemodynamic conditions of an artery bifurcation. Normal human umbilical vein ECs (HUVECs) and HUVECs with P120 catenin (P120ctn) knockdown were cultured on coverslips and placed in the chamber. Read More

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http://dx.doi.org/10.3892/mmr.2018.9657DOI Listing
January 2019
2 Reads

Escalating Opioid Dose Is Associated With Mortality: A Comparison of Patients With and Without Opioid Use Disorder.

J Addict Med 2019 Jan/Feb;13(1):41-46

University of California, Los Angeles, CA (YIH, LJM, KM, YZ, CKY, DH, DSB); Veterans Affairs Puget Sound Health Care System, Seattle, WA (AJS); University of California, San Diego, CA (DL).

Objective: Prescription Drug Monitoring Programs (PDMPs) are intended to help reduce prescription drug misuse and opioid overdose, yet little is known about the longitudinal patterns of opioid prescribing that may be associated with mortality. This study investigated longitudinal opioid prescribing patterns among patients with opioid use disorder (OUD) and without OUD in relation to mortality using PDMP data.

Methods: Growth modeling was used to examine opioid prescription data from the California PDMP for a 4-year period before death or a comparable period ending in 2014 for those remaining from a sample of 7728 patients (2576 with OUD, and 5152 matched non-OUD controls) treated in a large healthcare system. Read More

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http://Insights.ovid.com/crossref?an=01271255-900000000-9942
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http://dx.doi.org/10.1097/ADM.0000000000000458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349485PMC
January 2020
6 Reads

GG Protects the Epithelial Barrier of Wistar Rats from the Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy.

Nutrients 2018 Nov 7;10(11). Epub 2018 Nov 7.

Laboratory of Nutritional Pathophysiology, National Institute of Gastroenterology "S. de Bellis" Research Hospital, 70013 Castellana Grotte (Ba), Italy.

Celiac disease (CD) is a chronic immune-mediated disorder, characterized by enhanced paracellular permeability across the intestinal epithelium. The complex system of intercellular junctions, including tight junctions (TJs) and adherens junctions (AJs), seals together the epithelial cells to form a continuous layer. The improvements in barrier integrity have been related to modifications in intercellular junction protein expression. Read More

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http://www.mdpi.com/2072-6643/10/11/1698
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http://dx.doi.org/10.3390/nu10111698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265991PMC
November 2018
4 Reads
3.150 Impact Factor

An alternative mode of epithelial polarity in the Drosophila midgut.

PLoS Biol 2018 Oct 19;16(10):e3000041. Epub 2018 Oct 19.

The Gurdon Institute and the Department of Genetics, University of Cambridge, Cambridge, United Kingdom.

Apical-basal polarity is essential for the formation and function of epithelial tissues, whereas loss of polarity is a hallmark of tumours. Studies in Drosophila have identified conserved polarity factors that define the apical (Crumbs, Stardust, Par-6, atypical protein kinase C [aPKC]), junctional (Bazooka [Baz]/Par-3), and basolateral (Scribbled [Scrib], Discs large [Dlg], Lethal [2] giant larvae [Lgl]) domains of epithelial cells. Because these conserved factors mark equivalent domains in diverse types of vertebrate and invertebrate epithelia, it is generally assumed that this system underlies polarity in all epithelia. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209374PMC
October 2018
2 Reads

Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics.

Dev Cell 2018 10;47(1):3-19

Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, 75248 Paris Cedex 05, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, CNRS UMR 3215, INSERM U934, 75005 Paris, France. Electronic address:

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs) ensure intercellular adhesion and tissue integrity while allowing for cell and tissue dynamics. Mechanical forces play critical roles in AJs' composition and dynamics. Recent findings highlight that beyond a well-established role in reinforcing cell-cell adhesion, AJ mechanosensitivity promotes junctional remodeling and polarization, thereby regulating critical processes such as cell intercalation, division, and collective migration. Read More

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http://dx.doi.org/10.1016/j.devcel.2018.09.014DOI Listing
October 2018
7 Reads

Intercalated discs: cellular adhesion and signaling in heart health and diseases.

Heart Fail Rev 2019 Jan;24(1):115-132

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

Intercalated discs (ICDs) are highly orchestrated structures that connect neighboring cardiomyocytes in the heart. Three major complexes are distinguished in ICD: desmosome, adherens junction (AJ), and gap junction (GJ). Desmosomes are major cell adhesion junctions that anchor cell membrane to the intermediate filament network; AJs connect the actin cytoskeleton of adjacent cells; and gap junctions metabolically and electrically connect the cytoplasm of adjacent cardiomyocytes. Read More

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http://link.springer.com/10.1007/s10741-018-9743-7
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http://dx.doi.org/10.1007/s10741-018-9743-7DOI Listing
January 2019
7 Reads

Adherens junction-associated pores mediate the intercellular transport of endosomes and cytoplasmic proteins.

Biochem Biophys Res Commun 2018 Nov 2;505(3):664-670. Epub 2018 Oct 2.

Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, 30013, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 30010, Taiwan. Electronic address:

Intercellular endosomes (IEs) are endocytosed vesicles shuttled through the adherens junctions (AJs) between two neighboring epidermal cells during Drosophila dorsal closure. The cell-to-cell transport of IEs requires DE-cadherin (DE-cad), microtubules (MTs) and kinesin. However, the mechanisms by which IEs can be transported through the AJs are unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183206
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http://dx.doi.org/10.1016/j.bbrc.2018.09.129DOI Listing
November 2018
10 Reads

Direct-to-consumer DNA testing of 6,000 dogs reveals 98.6-kb duplication associated with blue eyes and heterochromia in Siberian Huskies.

PLoS Genet 2018 10 4;14(10):e1007648. Epub 2018 Oct 4.

Embark Veterinary, Inc., Boston, Massachusetts, United States of America.

Consumer genomics enables genetic discovery on an unprecedented scale by linking very large databases of personal genomic data with phenotype information voluntarily submitted via web-based surveys. These databases are having a transformative effect on human genomics research, yielding insights on increasingly complex traits, behaviors, and disease by including many thousands of individuals in genome-wide association studies (GWAS). The promise of consumer genomic data is not limited to human research, however. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171790PMC
October 2018
3 Reads

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 4;315(6):G966-G979. Epub 2018 Oct 4.

Department of Clinical Sciences, Center for Gastrointestinal Biology and Disease, College of Veterinary Medicine, North Carolina State University , Raleigh, North Carolina.

Adherens junctions (AJs), together with tight junctions (TJs), form an apical junctional complex that regulates intestinal epithelial cell-to-cell adherence and barrier homeostasis. Within the AJ, membrane-bound E-cadherin binds β-catenin, which functions as an essential intracellular signaling molecule. We have previously identified a novel protein in the region of the apical junction complex, chloride channel protein-2 (ClC-2), that we have used to study TJ regulation. Read More

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https://www.physiology.org/doi/10.1152/ajpgi.00087.2018
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http://dx.doi.org/10.1152/ajpgi.00087.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336945PMC
December 2018
3 Reads

Role of Oleanolic acid in maintaining BBB integrity by targeting p38MAPK/VEGF/Src signaling pathway in rat model of subarachnoid hemorrhage.

Eur J Pharmacol 2018 Nov 19;839:12-20. Epub 2018 Sep 19.

Institute of Neurology, General Hospital of Shenyang Military Command, Shenyang, Liaoning 110016, China. Electronic address:

Vasogenic brain edema after subarachnoid hemorrhage (SAH) is an independent risk factor for death and poor prognosis. Disruption of the blood-brain barrier (BBB) is the main cause of vasogenic brain edema induced by SAH. Oleanolic acid (OA) is a natural pentacyclic triterpenoid with various biological functions. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.09.018DOI Listing
November 2018
7 Reads

Tensile Loads on Tethered Actin Filaments Induce Accumulation of Cell Adhesion-Associated Proteins in Vitro.

Langmuir 2018 Sep 25. Epub 2018 Sep 25.

Department of Physiology , Nagoya University Graduate School of Medicine , Nagoya , Aichi 466-8550 , Japan.

Focal adhesions (FAs) and adherens junctions (AJs), which serve as a mechanical interface of cell-matrix and cell-cell interactions, respectively, experience tensile force either originating from the deformation of the surrounding tissues or generated by the actomyosin machinery in the cell. These mechanical inputs cause enlargement of FAs and AJs, while the detailed mechanism for the force-dependent development of FAs and AJs remain unclear. Both FAs and AJs provide sites for tethering of actin filaments and actin polymerization. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b02076DOI Listing
September 2018

Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis.

Nat Cell Biol 2018 10 10;20(10):1126-1133. Epub 2018 Sep 10.

DFG Cluster of Excellence 'Cells in Motion', (EXC 1003), Münster, Germany.

Coordinated rearrangements of cytoskeletal structures are the principal source of forces that govern cell and tissue morphogenesis. However, unlike for actin-based mechanical forces, our knowledge about the contribution of forces originating from other cytoskeletal components remains scarce. Here, we establish microtubules as central components of cell mechanics during tissue morphogenesis. Read More

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http://www.nature.com/articles/s41556-018-0193-1
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http://dx.doi.org/10.1038/s41556-018-0193-1DOI Listing
October 2018
35 Reads

Pancreatic Exocrine Tissue Architecture and Integrity are Maintained by E-cadherin During Postnatal Development.

Sci Rep 2018 Sep 7;8(1):13451. Epub 2018 Sep 7.

Department of Translational Research and Cellular Therapeutics, Diabetes and Metabolic Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.

Cadherin-mediated cell-cell adhesion plays an important role in organ development and changes in cadherin expression are often linked to morphogenetic and pathogenic events. Cadherins interact with other intracellular components to form adherens junctions (AJs) and provide mechanical attachments between adjacent cells. E-cadherin (Cdh1) represents an integral component of these intercellular junctions. Read More

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http://www.nature.com/articles/s41598-018-31603-2
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http://dx.doi.org/10.1038/s41598-018-31603-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128895PMC
September 2018
5 Reads

Histamine causes endothelial barrier disruption via Ca-mediated RhoA activation and tension at adherens junctions.

Sci Rep 2018 Sep 5;8(1):13229. Epub 2018 Sep 5.

Institute of Anatomy and Cell Biology Department I, Ludwig-Maximilians-Universität München, Munich, Germany.

During inflammation, the disruption of the endothelial barrier leads to increased microvascular permeability. Whether tension along cell junctions contributes to histamine-induced endothelial barrier disruption remains unknown. Rapid Ca influx induced by both histamine and thrombin was accompanied by endothelial barrier breakdown revealed as drop of transendothelial electric resistance in primary human microvascular endothelial cells. Read More

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http://dx.doi.org/10.1038/s41598-018-31408-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125323PMC
September 2018

A New Look at Familial Risk of Inflammatory Bowel Disease in the Ashkenazi Jewish Population.

Dig Dis Sci 2018 11 3;63(11):3049-3057. Epub 2018 Sep 3.

Centre for Molecular Medicine, Division of Medicine, University College London, London, UK.

Background And Aims: The inflammatory bowel diseases (IBD) are particularly common among the Ashkenazi Jewish (AJ) population. Population-specific estimates of familial risk are important for counseling; however, relatively small cohorts of AJ IBD patients have been analyzed for familial risk to date. This study aimed to recruit a new cohort of AJ IBD patients, mainly from the UK, to determine the familial occurrence of disease. Read More

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http://dx.doi.org/10.1007/s10620-018-5219-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182437PMC
November 2018
4 Reads

Mechanisms of Blood Brain Barrier Disruption by Different Types of Bacteria, and Bacterial-Host Interactions Facilitate the Bacterial Pathogen Invading the Brain.

Cell Mol Neurobiol 2018 Oct 16;38(7):1349-1368. Epub 2018 Aug 16.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.

This review aims to elucidate the different mechanisms of blood brain barrier (BBB) disruption that may occur due to invasion by different types of bacteria, as well as to show the bacteria-host interactions that assist the bacterial pathogen in invading the brain. For example, platelet-activating factor receptor (PAFR) is responsible for brain invasion during the adhesion of pneumococci to brain endothelial cells, which might lead to brain invasion. Additionally, the major adhesin of the pneumococcal pilus-1, RrgA is able to bind the BBB endothelial receptors: polymeric immunoglobulin receptor (pIgR) and platelet endothelial cell adhesion molecule (PECAM-1), thus leading to invasion of the brain. Read More

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http://link.springer.com/10.1007/s10571-018-0609-2
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http://dx.doi.org/10.1007/s10571-018-0609-2DOI Listing
October 2018
19 Reads
2.510 Impact Factor

Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells.

Vascul Pharmacol 2018 Aug 13. Epub 2018 Aug 13.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Endothelial hyperpermeability represents an initiating step in early atherosclerosis and it often occurs as a result of endothelial barrier dysfunction. Asiatic acid, a major triterpene isolated from Centella asiatica (L.) Urban, has previously been demonstrated to protect against tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Read More

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http://dx.doi.org/10.1016/j.vph.2018.08.005DOI Listing
August 2018
14 Reads
4.620 Impact Factor

CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions.

Angiogenesis 2019 Feb 10;22(1):75-93. Epub 2018 Aug 10.

Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.

Vascular endothelial (VE) cadherin is a key component of endothelial adherens junctions (AJs) and plays an important role in maintaining vascular integrity. Endocytosis of VE-cadherin regulates junctional strength and a decrease of surface VE-cadherin reduces vascular stability. However, disruption of AJs is also a requirement for vascular sprouting. Read More

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http://dx.doi.org/10.1007/s10456-018-9638-1DOI Listing
February 2019
6 Reads

Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention.

J Neuroophthalmol 2018 Dec;38(4):522-530

Department of Metabolic Neurology (CH, SPM, HB, AJS), Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; Birmingham Neuro-Ophthalmology Unit (SPM, AJS), Ophthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; Centre for Endocrinology, Diabetes and Metabolism (HB, MWOR, AJS), Birmingham Health Partners, United Kingdom; and Department of Neurology (AJS), University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

Background: Traditional risk factors associated with idiopathic intracranial hypertension (IIH) include obesity, weight gain, and female sex. The incidence of IIH is increasing and yet the underlying trigger and the fueling pathological mechanisms are still poorly understood.

Evidence Acquisition: Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, and neurosurgery literature was made. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215484PMC
December 2018

RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury.

Autophagy 2018 26;14(10):1677-1692. Epub 2018 Jul 26.

a Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China.

Microvascular barrier dysfunction is the central pathophysiological feature of acute lung injury (ALI). RAB26 is a newly identified small GTPase involved in the regulation of endothelial cell (EC) permeability. However, the mechanism behind this protection has not been clearly elucidated. Read More

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http://dx.doi.org/10.1080/15548627.2018.1476811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135632PMC
July 2018
2 Reads
11.753 Impact Factor

α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.

Cell Rep 2018 Jun;23(12):3447-3456

Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan; AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. Electronic address:

Adherens junctions (AJs) control epithelial cell behavior, such as collective movement and morphological changes, during development and in disease. However, the molecular mechanism of AJ remodeling remains incompletely understood. Here, we report that the conformational activation of α-catenin is the key event in the dynamic regulation of AJ remodeling. Read More

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http://dx.doi.org/10.1016/j.celrep.2018.05.070DOI Listing
June 2018
365 Reads

Interferon-γ induces biphasic changes in caldesmon localization as well as adherens junction organization and expression in HUVECs.

Cytokine 2018 Nov 14;111:541-550. Epub 2018 Jun 14.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ disrupts the endothelial barrier have not been clarified. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.06.010DOI Listing
November 2018
1 Read
2.664 Impact Factor

Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury.

Cell Death Discov 2018 16;4:60. Epub 2018 May 16.

1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.

Vascular endothelial cadherin (VE-cad) expression at endothelial adherens junctions (AJs) regulates vascular homeostasis. Here we show that endothelial A20 is required for VE-cad expression at AJs to maintain and repair the injured endothelial barrier. In endothelial cell (EC)-restricted (A20) knockout ( ) mice, LPS challenge caused uncontrolled lung vascular leak and persistent sequestration of polymorphonuclear neutrophil (PMNs). Read More

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http://www.nature.com/articles/s41420-018-0056-3
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http://dx.doi.org/10.1038/s41420-018-0056-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955943PMC
May 2018
6 Reads

Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish.

Toxicol Appl Pharmacol 2018 07 4;350:32-42. Epub 2018 May 4.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. Electronic address:

Impaired vascular integrity leads to serious cerebral vascular diseases such as intracerebral hemorrhage (ICH). In addition, high-dose statin therapy is suggested to cause increased ICH risk due to unclear effects of general inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) on the vascular system. Here we evaluated the protective effects of sodium tanshinone IIA sulfonate (STS), which has high efficacy and safety in clinical studies of ischemic stroke, by using atorvastatin (Ator) induced ICH zebrafish embryos and human umbilical vein endothelial cells (HUVECs). Read More

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http://dx.doi.org/10.1016/j.taap.2018.04.037DOI Listing
July 2018
8 Reads

The Impact of Adherens and Tight Junctions on Physiological Function and Pathological Changes in the Retina.

Adv Exp Med Biol 2018 ;1074:545-551

The Jackson Laboratory, Bar Harbor, ME, USA.

The formation of solid tissues is not a simple aggregation of individual cells but rather an ordered assembly of cells connected by junctions. These junctions provide a diffusion barrier as well as mechanical support and a conduit for signalling changes in the environment to the cells. Cell junctions are functionally categorized as occluding (e. Read More

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http://dx.doi.org/10.1007/978-3-319-75402-4_66DOI Listing
January 2018
4 Reads

Adherens junctions influence tight junction formation via changes in membrane lipid composition.

J Cell Biol 2018 Jul 2;217(7):2373-2381. Epub 2018 May 2.

Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan

Tight junctions (TJs) are essential cell adhesion structures that act as a barrier to separate the internal milieu from the external environment in multicellular organisms. Although their major constituents have been identified, it is unknown how the formation of TJs is regulated. TJ formation depends on the preceding formation of adherens junctions (AJs) in epithelial cells; however, the underlying mechanism remains to be elucidated. Read More

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http://dx.doi.org/10.1083/jcb.201711042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028530PMC
July 2018
3 Reads

Spatial and temporal organization of cadherin in punctate adherens junctions.

Proc Natl Acad Sci U S A 2018 05 24;115(19):E4406-E4415. Epub 2018 Apr 24.

Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611;

Adherens junctions (AJs) play a fundamental role in tissue integrity; however, the organization and dynamics of the key AJ transmembrane protein, E-cadherin, both inside and outside of AJs, remain controversial. Here we have studied the distribution and motility of E-cadherin in punctate AJs (pAJs) of A431 cells. Using single-molecule localization microscopy, we show that pAJs in these cells reach more than 1 μm in length and consist of several cadherin clusters with crystal-like density interspersed within sparser cadherin regions. Read More

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http://dx.doi.org/10.1073/pnas.1720826115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948979PMC
May 2018
5 Reads
1 Citation
9.810 Impact Factor

Home treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluation.

Thorax 2018 08 21;73(8):713-722. Epub 2018 Apr 21.

Respiratory Department, Northumbria Healthcare NHS Foundation Trust, North Shields, UK.

Background: Previous models of Hospital at Home (HAH) for COPD exacerbation (ECOPD) were limited by the lack of a reliable prognostic score to guide patient selection. Approximately 50% of hospitalised patients have a low mortality risk by DECAF, thus are potentially suitable.

Methods: In a non-inferiority randomised controlled trial, 118 patients admitted with a low-risk ECOPD (DECAF 0 or 1) were recruited to HAH or usual care (UC). Read More

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http://dx.doi.org/10.1136/thoraxjnl-2017-211197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204956PMC
August 2018
7 Reads

Physiological stress responses in infants at 29-32 weeks' postmenstrual age during clustered nursing cares and standardised neurobehavioural assessments.

BMJ Paediatr Open 2017 25;1(1):e000025. Epub 2017 Nov 25.

Victorian Infant Brain Studies, Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Objective: To compare the physiological stress responses of infants born <30 weeks' gestational age when undergoing clustered nursing cares with standardised neurobehavioural assessments in neonatal nurseries.

Design/methods: Thirty-four infants born <30 weeks' gestation were recruited from a tertiary neonatal intensive care unit. Heart rate (HR) and oxygen saturation were recorded during clustered nursing cares and during standardised neurobehavioural assessments (including the General Movements Assessment, Hammersmith Neonatal Neurological Examination and Premie-Neuro Assessment). Read More

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http://dx.doi.org/10.1136/bmjpo-2017-000025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842990PMC
November 2017
6 Reads

Influence of diameter of fiber membrane scaffolds on the biocompatibility of hPDL mesenchymal stromal cells.

Dent Mater J 2018 Jun 17;37(3):465-473. Epub 2018 Mar 17.

Tissue Bioengineering Laboratory, Division of Graduate Studies and Research of the Faculty of Dentistry, UNAM.

This study evaluated the influence in the biocompatibility of human periodontal ligament (hPDL) mesenchymal stromal cell onto poly lactic-acid (PLA) films and PLA fiber membrane. Fiber scaffold was prepared via air jet spinning (AJS) from PLA solutions (6, 7, and 10%) and analyzed using SEM, AFM and FTIR. Biocompatibility was evaluated by adhesion, proliferation and cell-material interaction. Read More

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https://www.jstage.jst.go.jp/article/dmj/37/3/37_2016-329/_a
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http://dx.doi.org/10.4012/dmj.2016-329DOI Listing
June 2018
44 Reads

The force-sensing device region of α-catenin is an intrinsically disordered segment in the absence of intramolecular stabilization of the autoinhibitory form.

Genes Cells 2018 May 15;23(5):370-385. Epub 2018 Mar 15.

Structural Biology Laboratory, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

Mechanotransduction by α-catenin facilitates the force-dependent development of adherens junctions (AJs) by recruiting vinculin to reinforce actin anchoring of AJs. The α-catenin mechanotransducing action is facilitated by its force-sensing device region that autoinhibits the vinculin-binding site 1 (VBS1). Here, we report the high-resolution structure of the force-sensing device region of α-catenin, which shows the autoinhibited form comprised of helix bundles E, F and G. Read More

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http://dx.doi.org/10.1111/gtc.12578DOI Listing
May 2018
7 Reads