40 results match your criteria AIMS genetics[Journal]

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The roles of genes in the bitter taste.

AIMS Genet 2019 24;6(4):88-97. Epub 2019 Dec 24.

Department of Biology, Faculty of science and health, Koya University Koya KOY45, Kurdistan Region-F.R. Iraq.

The aims of this review were to understand the roles of bitter taste genes in humans. Some of the peoples have the capacity to taste some chemical substance such as phenylthiocarbamide (PTC) while others cant not based on the dietary hazards and food preferences. There are two alleles responsible to express these phenotypes which are homozygous recessive. Read More

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http://dx.doi.org/10.3934/genet.2019.4.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949464PMC
December 2019

Evidence for novel epigenetic marks within plants.

AIMS Genet 2019 24;6(4):70-87. Epub 2019 Dec 24.

School of School of Agriculture, Policy and Development, University of Reading, Reading, Berkshire, UK.

Variation in patterns of gene expression can result from modifications in the genome that occur without a change in the sequence of the DNA; such modifications include methylation of cytosine to generate 5-methylcytosine (5mC) resulting in the generation of heritable epimutation and novel epialleles. This type of non-sequence variation is called epigenetics. The enzymes responsible for generation of such DNA modifications in mammals are named DNA methyltransferases (DNMT) including DNMT1, DNMT2 and DNMT3. Read More

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http://dx.doi.org/10.3934/genet.2019.4.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949463PMC
December 2019

A robust circular RNA-based prognostic signature for postoperative recurrence in stage II/III colon cancer.

Authors:
Ji Ruan

AIMS Genet 2019 30;6(4):67-69. Epub 2019 Sep 30.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

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http://dx.doi.org/10.3934/genet.2019.4.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949465PMC
September 2019

Re-engineering anti-CTLA-4 antibodies for enhancing cancer immunotherapy efficacy and safety.

AIMS Genet 2019 19;6(3):64-66. Epub 2019 Sep 19.

Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, Guangdong, P. R. China.

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http://dx.doi.org/10.3934/genet.2019.3.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803786PMC
September 2019

gene polymorphism in Russian patients with panic disorder.

AIMS Genet 2019 20;6(3):55-63. Epub 2019 Aug 20.

Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia.

Background: Panic disorder is a complex disease of unclear etiology but with an apparent genetic component. gene product is involved in many cell processes owing to its function-regulation of the level of a second messenger cAMP. gene polymorphism has been shown to be associated with some mental disorders including panic disorder. Read More

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http://dx.doi.org/10.3934/genet.2019.3.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803789PMC

Molecular characterization of the receptor in larvae.

AIMS Genet 2019 8;6(3):46-54. Epub 2019 Aug 8.

Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Larval therapy with is a promising strategy in wound healing. Axon guidance molecules play vital roles during the development of the nervous system and also regulate the capacity of neuronal restoration in wound healing. , one of the proteins that larvae secrete, plays a useful role in cell migration and nerve tissue regeneration. Read More

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http://dx.doi.org/10.3934/genet.2019.3.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803787PMC

The epigenetics of diabetes, obesity, overweight and cardiovascular disease.

AIMS Genet 2019 1;6(3):36-45. Epub 2019 Aug 1.

Department of Biology, Faculty of science and health, Koya University Koya KOY45, Kurdistan Region-F.R. Iraq.

The objectives of this review were once to understand the roles of the epigenetics mechanism in different types of diabetes, obesity, overweight, and cardiovascular disease. Epigenetics represents a phenomenon of change heritable phenotypic expression of genetic records taking place except changes in DNA sequence. Epigenetic modifications can have an impact on a whole of metabolic disease with the aid of specific alteration of candidate genes based totally on the change of the target genes. Read More

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http://dx.doi.org/10.3934/genet.2019.3.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803788PMC

Correction: Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells.

AIMS Genet 2018;5(3):191. Epub 2018 Sep 13.

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

[This corrects the article DOI: 10.3934/genet.2018. Read More

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http://dx.doi.org/10.3934/genet.2018.3.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690229PMC
September 2018

Physiological responses and transcriptome analysis of the (L.) Schrad. to seedling drought stress.

AIMS Genet 2019 5;6(2):17-35. Epub 2019 Jun 5.

Inner Mongolia Agricultural University, College of Grassland, Resources and Environment, Grass resource genetic breeding, China.

is a good forage plant, which has important economic and ecological value in arid and semi-arid regions of China. Drought is one of the main factors affecting its productivity. At present, there are few studies on the mechanism of drought resistance. Read More

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http://www.aimspress.com/article/10.3934/genet.2019.2.17
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http://dx.doi.org/10.3934/genet.2019.2.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690244PMC
June 2019
1 Read

Histone glycation: Linking metabolic perturbation with epigenetic misregulation in cancer.

Authors:
Xiayao Diao

AIMS Genet 2019 4;6(2):14-16. Epub 2019 Jun 4.

Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 33 Yingfeng Road, Haizhu District, Guangzhou 510220, P. R. China.

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http://dx.doi.org/10.3934/genet.2019.2.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690245PMC

Linking metabolic and epigenetic regulation in the development of lung cancer driven by TGFβ signaling.

Authors:
Liyi Zhang

AIMS Genet 2019 3;6(2):11-13. Epub 2019 Jun 3.

Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P. R. China.

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http://dx.doi.org/10.3934/genet.2019.2.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690243PMC

Cd + Cr causes toxic effects on chromosomal development of microspore in .

AIMS Genet 2019 10;6(1):1-10. Epub 2019 Apr 10.

Department of Botany C.C.S. University Meerut-250004, India.

Intra-category hybrids of were analyzed for the genetic toxicity in detail for effect of Cd + Cr on reproductive biology of . Five partially tolerant and five non-tolerant accessions of after screening were crossed to produce intra-category hybrid. These two heavy metals in combination influenced antagonistically first as well as second meiotic divisions inducing various kinds of anomalies and reduced the number of pollen grains per anther and significantly increased pollen sterility. Read More

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http://dx.doi.org/10.3934/genet.2019.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690227PMC
April 2019
6 Reads

Starless bias and parameter-estimation bias in the likelihood-based phylogenetic method.

Authors:
Xuhua Xia

AIMS Genet 2018 9;5(4):212-223. Epub 2019 Apr 9.

Department of Biology, University of Ottawa, Ottawa, Canada, K1N 6N5.

I analyzed various site pattern combinations in a 4-OTU case to identify sources of starless bias and parameter-estimation bias in likelihood-based phylogenetic methods, and reported three significant contributions. First, the likelihood method is counterintuitive in that it may not generate a star tree with sequences that are equidistant from each other. This behaviour, dubbed starless bias, happens in a 4-OTU tree when there is an excess (i. Read More

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http://dx.doi.org/10.3934/genet.2018.4.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690233PMC

Homologous recombination defects and how they affect replication fork maintenance.

AIMS Genet 2018 3;5(4):192-211. Epub 2019 Apr 3.

Department of Molecular Medicine and Institute of Biotechnology, UT Health San Antonio, 15355 Lambda Drive, San Antonio, USA.

Homologous recombination (HR) repairs DNA double strand breaks (DSBs) and stabilizes replication forks (RFs). RAD51 is the recombinase for the HR pathway. To preserve genomic integrity, RAD51 forms a filament on the 3' end of a DSB and on a single-stranded DNA (ssDNA) gap. Read More

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http://dx.doi.org/10.3934/genet.2018.4.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690234PMC

Panic disorders: The role of genetics and epigenetics.

AIMS Genet 2018 27;5(3):177-190. Epub 2018 Jul 27.

Department of Psychiatry, Korea University Ansan Hospital, Ansan, Republic of Korea.

Panic disorder is characterized by symptoms with abrupt surges of fear with palpitations, sweating, trembling, heat sensations. Considering its disease burden on each individual and on society, understanding its etiology is important. Though no one specific etiology has been known, like other psychiatric disorders, multiple factors such as genetic, environmental, neurobiological, psychopathological factors have been suggested. Read More

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http://dx.doi.org/10.3934/genet.2018.3.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690230PMC
July 2018
3 Reads

Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm.

AIMS Genet 2018 7;5(1):24-40. Epub 2018 Feb 7.

Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

The Leprecan protein family which includes the prolyl 3-hydroxylase enzymes (P3H1, P3H2, and P3H3), the closely related cartilage-associated protein (CRTAP), and SC65 (Synaptonemal complex 65, aka P3H4, LEPREL4), is involved in the post-translational modification of fibrillar collagens. Mutations in , and cause human genetic diseases. We recently showed that SC65 forms a stable complex in the endoplasmic reticulum with P3H3 and lysyl hydroxylase 1 and that loss of this complex leads to defective collagen lysyl hydroxylation and causes low bone mass and skin fragility. Read More

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http://dx.doi.org/10.3934/genet.2018.1.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221197PMC
February 2018
2 Reads

The possible function of Flp1 in homologous recombination repair in .

AIMS Genet 2018 3;5(2):161-176. Epub 2018 Apr 3.

NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh city, Vietnam.

Mus81 is a structure-selective endonuclease which constitutes an alternative pathway in parallel with the helicase-topoisomerase Sgs1-Top3-Rmi1 complex to resolve a number of DNA intermediates during DNA replication, repair, and homologous recombination. Previously, it was showed that the N-terminal region of Mus81 was required for its function in a redundant manner with Sgs1; mutant that lacks the first 120 amino acid residues at the N-terminus exhibited synthetic lethality in combination with the loss of . In this study, the physiologically important role of the N-terminal region of Mus81 in processing toxic intermediates was further investigated. Read More

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http://dx.doi.org/10.3934/genet.2018.2.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698574PMC

Non-centrosomal MTs play a crucial role in organization of MT array in interphase fibroblasts.

AIMS Genet 2018 28;5(2):141-160. Epub 2018 Mar 28.

Biology Department, M.V. Lomonosov Moscow State University, Moscow, Russia.

Microtubules in interphase fibroblast-like cells are thought to be organized in a radial array growing from a centrosome-based microtubule-organizing center (MTOC) to the cell edges. However, many morphogenetic processes require the asymmetry of the microtubules (MT) array. One of the possible mechanisms of this asymmetry could be the presence of non-centrosomal microtubules in different intracellular areas. Read More

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http://dx.doi.org/10.3934/genet.2018.2.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698575PMC

The role of long non-coding RNAs in cardiac development and disease.

AIMS Genet 2018 26;5(2):124-140. Epub 2018 Mar 26.

Cardiovascular Development Group, Department of Experimental Biology, University of Jaén, Jaén, Spain.

Cells display a set of RNA molecules at one time point, reflecting thus the cellular transcriptional steady state, configuring therefore its transcriptome. It is basically composed of two different classes of RNA molecules; protein-coding RNAs (cRNAs) and protein non-coding RNAs (ncRNAs). Sequencing of the human genome and subsequently the ENCODE project identified that more than 80% of the genome is transcribed in some type of RNA. Read More

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http://dx.doi.org/10.3934/genet.2018.2.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698576PMC

Preferable location of chromosomes 1, 29, and X in bovine spermatozoa.

AIMS Genet 2018 21;5(2):113-123. Epub 2018 Mar 21.

The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Virginia, USA.

Chromosome positioning in sperm nucleus may have a functional significance by influencing the sequence of post-fertilization events. In this study we present data on preferential locations of chromosomes 1, 29 and X in spermatozoa. Here we demonstrate that the position of X chromosome in the sperm nucleus is more restricted as compared to the position of chromosome 1, which is about of the same size. Read More

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http://dx.doi.org/10.3934/genet.2018.2.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698578PMC

Towards an advanced cell-based glioma model system.

AIMS Genet 2018 19;5(2):91-112. Epub 2018 Mar 19.

Center for Genomic and Regenerative Medicine, School of Biomedicine, Far Eastern Federal University, Vladivostok, Russian Federation.

The modulation of tumor growth and development has always been one of the key factors in the research of the malignant transformation, including gliomas, prevalent and most deadly cancers of the brain. Indeed, cellular and molecular biology research employing model cell-based systems have great potential to advance both the mechanistic understanding and the treatment of human glial tumors, as it facilitates not only the understanding of glioma biology and its regulatory mechanisms Additionally they promise to afford the screening of the putative anti-tumor agents and alternative treatment approaches in a personalized manner, i.e. Read More

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http://dx.doi.org/10.3934/genet.2018.2.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698577PMC

Esophageal cancer research today and tomorrow: Lessons from algae and other perspectives.

AIMS Genet 2018 7;5(1):75-90. Epub 2018 Mar 7.

Centre for Genomic and Regenerative Medicine, School of Biomedicine, FEFU, 8 Sukhanova str, Vladivostok, Primorsky region, 690950, Russian Federation.

Esophageal cancer is an increasing concern due to poor prognosis, aggressive disease modalities, and a lack of efficient therapeutics. The two types of esophageal cancer: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are responsible for an estimated 450,000 annual deaths, with over 457,000 new patients diagnosed in 2015, making it the eighth most prevalent and the 10th most fatal cancer worldwide. As esophageal cancer prevalence continues to increase, and so does the pressing need for the development of new and effective strategies for the early diagnostics, prevention, and treatment of this cancer, as well for building the innovative research tools to understand the affected molecular mechanisms. Read More

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http://dx.doi.org/10.3934/genet.2018.1.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690251PMC

Rpb5, a subunit shared by eukaryotic RNA polymerases, cooperates with prefoldin-like Bud27/URI.

AIMS Genet 2018 27;5(1):63-74. Epub 2018 Feb 27.

Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Paraje de las Lagunillas, s/n, 23071, Jaén, Spain.

Rpb5 is one of the five common subunits to all eukaryotic RNA polymerases, which is conserved in archaea, but not in bacteria. Among these common subunits, it is the only one that is not interchangeable between yeasts and humans, and accounts for the functional incompatibility of yeast and human subunits. Rpb5 has been proposed to contribute to the gene-specific activation of RNA pol II, notably during the infectious cycle of the hepatitis B virus, and also to participate in general transcription mediated by all eukaryotic RNA pol. Read More

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http://dx.doi.org/10.3934/genet.2018.1.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690254PMC
February 2018

Identification of a novel functional miR-143-5p recognition element in the Cystic Fibrosis Transmembrane Conductance Regulator 3'UTR.

AIMS Genet 2018 23;5(1):53-62. Epub 2018 Feb 23.

Lung Biology Group, Department of Clinical Microbiology, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland.

MicroRNAs (miRNAs) are small non-coding RNAs involved in regulation of gene expression. They bind in a sequence-specific manner to miRNA recognition elements (MREs) located in the 3' untranslated region (UTR) of target mRNAs and prevent mRNA translation. MiRNA expression is dysregulated in cystic fibrosis (CF), affecting several biological processes including ion conductance in the epithelial cells of the lung. Read More

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http://dx.doi.org/10.3934/genet.2018.1.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690249PMC
February 2018

Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells.

AIMS Genet 2018 8;5(1):41-52. Epub 2018 Feb 8.

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS). Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process. Read More

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http://dx.doi.org/10.3934/genet.2018.1.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690250PMC
February 2018

Our love-hate relationship with DNA barcodes, the Y2K problem, and the search for next generation barcodes.

Authors:
Jeffrey M Marcus

AIMS Genet 2018 17;5(1):1-23. Epub 2018 Jan 17.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada, R3T 2N2.

DNA barcodes are very useful for species identification especially when identification by traditional morphological characters is difficult. However, the short mitochondrial and chloroplast barcodes currently in use often fail to distinguish between closely related species, are prone to lateral transfer, and provide inadequate phylogenetic resolution, particularly at deeper nodes. The deficiencies of short barcode identifiers are similar to the deficiencies of the short year identifiers that caused the Y2K problem in computer science. Read More

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http://dx.doi.org/10.3934/genet.2018.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690253PMC
January 2018

High frequency of microdeletion in gene family in peripheral blood leukocytes of non-obstructive azoospermia patients.

AIMS Genet 2017 15;4(4):202-212. Epub 2017 Dec 15.

Cytogenome Medical Genetics Laboratory, Chamran Medical Building, Ale-Ahmad Highway, Tehran, Iran.

About 10-15% of non-obstructive azoospermia (NOA) patients show microdeletion in their blood leukocytes. However, if genes were involved in impaired spermatogenesis, a higher frequency of chromosomal microdeletions was expected. In this study the frequency of microdeletion was compared with gene family, i. Read More

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http://dx.doi.org/10.3934/genet.2017.4.202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690235PMC
December 2017

Evidence for two types of nrDNA existing in Chinese medicinal fungus .

AIMS Genet 2017 25;4(3):192-201. Epub 2017 Aug 25.

Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan (R.O.C).

Nuclear ribosomal DNA (nrDNA) sequences are widely used in the molecular classification of fungi. Previous phylogenetic studies of highly-valued traditional Chinese medicinal fungus were mostly based on 18S and internal transcribed spacer (ITS) regions (ITS1, 5.8S and ITS2) of nrDNA. Read More

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http://dx.doi.org/10.3934/genet.2017.3.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690242PMC

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.

AIMS Genet 2017 5;4(1):21-31. Epub 2017 Jan 5.

Biology Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia.

DNA accessibility to various protein complexes is essential for various processes in the cell and is affected by nucleosome structure and dynamics. Protein factor PARP-1 (poly(ADP-ribose)polymerase 1) increases the accessibility of DNA in chromatin to repair proteins and transcriptional machinery, but the mechanism and extent of this chromatin reorganization are unknown. Here we report on the effects of PARP-1 on single nucleosomes revealed by spFRET (single-particle Förster Resonance Energy Transfer) microscopy. Read More

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http://dx.doi.org/10.3934/genet.2017.1.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552189PMC
January 2017
10 Reads

The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies.

AIMS Genet 2017 11;4(3):166-191. Epub 2017 Aug 11.

Faculty of Social Sciences, London Metropolitan University, London, United Kingdom.

Molecular epidemiology is an approach increasingly used in the establishment of associations between exposure to hazardous substances and development of disease, including the possible modulation by genetic susceptibility factors. Environmental chemicals and contaminants from anthropogenic pollution of air, water and soil, but also originating specifically in occupational contexts, are potential sources of risk of development of disease. Also, diet presents an important role in this process, with some well characterized associations existing between nutrition and some types of cancer. Read More

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http://dx.doi.org/10.3934/genet.2017.3.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690241PMC

In-silico based identification and functional analyses of miRNAs and their targets in Cowpea ( L.).

AIMS Genet 2017 29;4(2):138-165. Epub 2017 Jun 29.

Department of Botany, University of Balochistan, Sariab Road, Quetta, Pakistan.

Cowpea ( L.) is an important leguminous plant and a good diet due to presence of carbohydrate and high protein contents. Currently, only few cowpea microRNAs (miRNAs) are reported. Read More

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http://dx.doi.org/10.3934/genet.2017.2.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690248PMC

Both -dependent and independent pathways are involved in DNA damage-associated sister chromatid exchange in budding yeast.

AIMS Genet 2017 30;4(2):84-102. Epub 2017 Mar 30.

College of Nanoscale Sciences and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, New York 12203, United States.

Sister chromatids are preferred substrates for recombinational repair after cells are exposed to DNA damage. While some agents directly cause double-strand breaks (DSBs), others form DNA base adducts which stall or impede the DNA replication fork. We asked which types of DNA damage can stimulate SCE in budding yeast mutants defective in template switch mechanisms and whether PCNA polyubiquitination functions are required for DNA damage-associated SCE after exposure to potent recombinagens. Read More

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http://dx.doi.org/10.3934/genet.2017.2.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460634PMC
March 2017
21 Reads

DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity.

AIMS Genet 2017 18;4(2):103-137. Epub 2017 Apr 18.

Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein, crotonaldehyde and 4-hydroxy-2-nonenal, react with DNA bases, generating promutagenic exocyclic DNA adducts, which likely contribute to the mutagenic and carcinogenic effects associated with oxidative stress-induced LPO. Read More

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http://dx.doi.org/10.3934/genet.2017.2.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690246PMC

Role of some epigenetic factors in DNA damage response pathway.

AIMS Genet 2017 24;4(1):69-83. Epub 2017 Mar 24.

Department of Radiation Genetics and Epigenetics, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Road, Timarpur, Delhi 110054 India.

The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review. Read More

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http://dx.doi.org/10.3934/genet.2017.1.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690236PMC
March 2017
1 Read

Systematic analysis of DNA damage induction and DNA repair pathway activation by continuous wave visible light laser micro-irradiation.

AIMS Genet 2017 21;4(1):47-68. Epub 2017 Feb 21.

Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

Laser micro-irradiation can be used to induce DNA damage with high spatial and temporal resolution, representing a powerful tool to analyze DNA repair in the context of chromatin. However, most lasers induce a mixture of DNA damage leading to the activation of multiple DNA repair pathways and making it impossible to study individual repair processes. Hence, we aimed to establish and validate micro-irradiation conditions together with inhibition of several key proteins to discriminate different types of DNA damage and repair pathways using lasers commonly available in confocal microscopes. Read More

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http://dx.doi.org/10.3934/genet.2017.1.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690239PMC
February 2017
1 Read

A search for the common ground between Tic; Obsessive-compulsive and Autism Spectrum Disorders: part I, Tic disorders.

AIMS Genet 2017 21;4(1):32-46. Epub 2017 Feb 21.

Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

This article is the first of four articles designed to explore the complex interrelationship between Autism Spectrum Disorders (ASD); Obsessive compulsive and Related Disorders (OCRD) and Tic Disorders/Tourette's Syndrome (TD/TS). We begin with an overview TD/TS and follow-up with reviews of OCRD and ASD. The final article in this series represents a synthesis of the neurobiological and genetic markers shared by patients presenting with all three syndromes. Read More

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http://dx.doi.org/10.3934/genet.2017.1.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690237PMC
February 2017

Cardiac biomarkers in dialysis.

AIMS Genet 2017 26;4(1):1-20. Epub 2016 Dec 26.

Department of Nephrology, Princess Alexandra Hospital, Australia.

Cardiovascular disease is the major cause of death, accounting for approximately 40 percent of all-cause mortality in patients receiving either hemodialysis or peritoneal dialysis. Cardiovascular risk stratification is an important aspect of managing dialysis patients as it enables early identification of high-risk patients, so therapeutic interventions can be optimized to lower cardiovascular morbidity and mortality. Biomarkers can detect early stages of cardiac injury so timely intervention can be provided. Read More

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http://dx.doi.org/10.3934/genet.2017.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690238PMC
December 2016

Genetic and flow anomalies in congenital heart disease.

Authors:
Sandra Rugonyi

AIMS Genet 2016 23;3(3):157-166. Epub 2016 Aug 23.

Department of Biomedical Engineering, Oregon Health & Science University, 3303 SW Bond Ave. M/C CH13B, Portland, OR 97239, USA.

Congenital heart defects are the most common malformations in humans, affecting approximately 1% of newborn babies. While genetic causes of congenital heart disease have been studied, only less than 20% of human cases are clearly linked to genetic anomalies. The cause for the majority of the cases remains unknown. Read More

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http://dx.doi.org/10.3934/genet.2016.3.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417695PMC
August 2016
3 Reads

Non-autonomous consequences of cell death and other perks of being metazoan.

Authors:
Tin Tin Su

AIMS Genet 2015;2(1):54-69

Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA.

remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. Read More

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http://dx.doi.org/10.3934/genet.2015.1.54#sthash.dNy9tFhS.dpufDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461274PMC
January 2015
6 Reads

Allelic Interaction between and in the Pathogenesis of Cardiac Atrioventricular Septal Defects.

AIMS Genet 2014 ;1(1):1-19

Department of Physiology and the Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Atrioventricular septal defects (AVSD) are highly heritable, clinically significant congenital heart malformations. Genetic and environmental modifiers of risk are thought to work in unknown combinations to cause AVSD. Approximately 5-10% of simplex AVSD cases carry a missense mutation in . Read More

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http://www.aimspress.com/article/10.3934/genet.2014.1.1
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http://dx.doi.org/10.3934/genet.2014.1.1#sthash.jksuJTeC.dpufDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200510PMC
January 2014
24 Reads
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