3,619 results match your criteria AIDS-Related Lymphomas


Spectrum of imaging findings in AIDS-related diffuse large B cell lymphoma.

Insights Imaging 2020 May 19;11(1):67. Epub 2020 May 19.

Aga Khan University Hospital Nairobi, 3rd Parklands Avenue, Limuru Road, Nairobi, Kenya.

Lymphoma in HIV-infected patients is AIDS defining. This is the second most common AIDS defining malignancy after Kaposi's sarcoma. Development of lymphoma in HIV patients is related to immunosuppression and high viral load. Read More

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http://dx.doi.org/10.1186/s13244-020-00871-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237590PMC

Hiv-Related Lymphoprolipherative Diseases In The Era Of Combination Antiretroviral Therapy.

Cardiovasc Hematol Disord Drug Targets 2020 Apr 15. Epub 2020 Apr 15.

Infectious Diseases Unit, Hospital Health Direction, IRCCS Policlinico San Donato, San Donato Milanese, Milan . Italy.

HIV-positive patients have a 60- to 200-fold increased incidence of non-Hodgkin lymphomas (NHL) because of their impaired cellular immunity. Some NHL are considered acquired immunodeficiency syndrome (AIDS) defining conditions. Diffuse large B-cell Lymphoma (DLBC) and Burkitt lymphoma (BL) are the most commonly observed, whereas primary effusion lymphoma (PEL), Central Nervous System Lymphomas (PCNSL), plasmablastic lymphoma (PBL) and classic Hodgkin lymphoma (HL) are far less frequent. Read More

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http://dx.doi.org/10.2174/1871529X20666200415121009DOI Listing

Analysis of the causes of cervical lymphadenopathy using fine-needle aspiration cytology combining cell block in Chinese patients with and without HIV infection.

BMC Infect Dis 2020 Mar 14;20(1):224. Epub 2020 Mar 14.

Department of Pathology, Beijing Ditan Hospital,Captial Medical University, No. 8 Jing Shun East Street, Chaoyang District, Beijing, 100015, People's Republic of China.

Background: Cervical lymphadenopathy refers to a frequently observed clinical presentation in numerous pathological conditions. A wide spectrum of diseases can cause cervical lymphadenopathy, irrespective of the fact that the patients are infected with HIV or not. The present study focuses on validating whether the causes of cervical lymphadenopathy differ significantly in HIV and non-HIV patients by using fine-needle aspiration cytology (FNAC) combining cell block. Read More

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http://dx.doi.org/10.1186/s12879-020-4951-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071630PMC

Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma.

IDCases 2020 10;19:e00716. Epub 2020 Feb 10.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

A 68-year-old man with past medical history of multiple cerebral infarctions presented to our hospital with subacute paresis. His vital signs on presentation were normal, and his physical examination, other than his neurological findings, was unremarkable. Neurological examinations suggested cerebellar ataxia. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030992PMC
February 2020

Burkitt's lymphoma nodular cystic hepatosplenic, in HIV patient. Case report

Rev Med Inst Mex Seguro Soc 2019 05 2;57(3):187-190. Epub 2019 May 2.

Instituto Mexicano del Seguro Social. Hospital General de Zona No. 2. Servicio de Medicina Interna. Cárdenas, Tabasco, México

Background: Patients with human immunodeficiency virus (HIV) are more likely to develop cancer. Malignant lymphomas are the main cancer group seen in these patients. Diffuse large B-cell lymphoma including central nervous system lymphoma and Burkitt's lymphoma account for 90% of HIV-related non-Hodgkin's lymphomas. Read More

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Dichotomy in Fatal Outcomes in a Large Cohort of People Living with HTLV-1 in São Paulo, Brazil.

Pathogens 2019 Dec 26;9(1). Epub 2019 Dec 26.

Institute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo 01246-000, Brazil.

Despite its relatively low incidence of associated diseases, Human T-cell Leukemia Virus-1 (HTLV-1) infection was reported to carry a significant risk of mortality in several endemic areas. HTLV-1-associated diseases, adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraperesis (HAM/TSP), as well as frequent coinfections with human immunodeficiency virus (HIV), hepatitis C virus (HCV), and were associated to increased morbidity and mortality of HTLV-1 infection. To determine the mortality rate and its associated variables from an open cohort started in July 1997 at the HTLV Clinic, Emilio Ribas Institute (IIER), a major infectious disease hospital in São Paulo, Brazil. Read More

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http://dx.doi.org/10.3390/pathogens9010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168659PMC
December 2019

Outcomes of HIV-associated Burkitt Lymphoma in Brazil: High treatment toxicity and refractoriness rates - A multicenter cohort study.

Leuk Res 2020 Feb 10;89:106287. Epub 2019 Dec 10.

Instituto do Cancer de Sao Paulo (ICESP), Universidade de São Paulo, Av. Dr. Arnaldo, 251 - Cerqueira César, São Paulo, SP, 01246-000, Brazil; Laboratory of Medical Investigation on Pathogenesis and Targeted Therapy in Onco-immuno-hematology (LIM-31), Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 155 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.

Background: Although the increased use of combined antiretroviral therapy (cART) has decreased the incidence of lymphomas HIV-associated, Burkitt lymphoma (BL) incidence remains stable. Reported outcomes on HIV-associated BL from developed countries seem to corroborate that the regimens do not need to be tailored to the HIV-positive population.

Materials And Methods: This is a retrospective multicenter cohort study from Brazil, including HIV-positive patients aged 15 years and above diagnosed with BL. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.106287DOI Listing
February 2020

Hepatitis C virus or hepatitis B virus coinfection and lymphoma risk in people living with HIV.

AIDS 2020 03;34(4):599-608

Sorbonne Universités, INSERM, UPMC Université Paris 06, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS1136), Paris.

Objective: Chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are associated with increased risks of lymphomas in the non-HIV setting. Their impacts on HIV-associated lymphomas deserved further studies in the modern combined antiretroviral therapy (cART) era.

Design: We evaluated the associations between HCV, HBV and HIV-related lymphomas in the Lymphovir-ANRS-CO16 cohort. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002461DOI Listing
March 2020
5.554 Impact Factor

The option of treatment and outcomes for patients with AIDS-related diffuse large B-cell lymphoma from a resource-limited setting in China.

Leuk Lymphoma 2020 Apr 4;61(4):971-974. Epub 2019 Dec 4.

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.

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http://dx.doi.org/10.1080/10428194.2019.1697877DOI Listing

Associations of Viral Seroreactivity with AIDS-Related Non-Hodgkin Lymphoma.

AIDS Res Hum Retroviruses 2020 May 2;36(5):381-388. Epub 2020 Mar 2.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Infection with human immunodeficiency virus (HIV) is associated with substantially increased incidence of non-Hodgkin lymphoma (NHL). This risk may be driven, in part, by reduced immune control over viral infections in the setting of acquired immunodeficiency syndrome (AIDS), although the lymphomagenic mechanisms are not yet established. We used bead-based multiplex assays to measure antibody seroreactivity to 32 viral antigens representing 22 different viral infections (human herpesviruses 1-8, hepatitis B and C virus, human T-lymphotropic virus type-1, and human polyomaviruses) in two prospective HIV cohorts. Read More

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http://dx.doi.org/10.1089/AID.2019.0208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232664PMC

Reduced economic burden of AIDS-defining illnesses associated with adherence to antiretroviral therapy.

Int J Infect Dis 2020 Feb 15;91:44-49. Epub 2019 Nov 15.

Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objectives: We assessed the economic burden of AIDS-defining illnesses (ADIs), which was further stratified by adherence to antiretroviral therapy (ART).

Methods And Materials: A nationwide longitudinal cohort of 18,234 incident cases with HIV followed for 11years was utilized. Adherence to ART was measured by medication possession ratio (MPR). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.11.010DOI Listing
February 2020

HIV/AIDS-related lymphoma: perspective from a regional cancer center in India.

Blood Res 2019 Sep 25;54(3):181-188. Epub 2019 Sep 25.

Department of Pathology, Kidwai Cancer Institute, Bengaluru, India.

Background: India has the third largest population of people living with HIV/AIDS (PLHA). Lymphoma is the second most common malignancy among PLHA. However, data are lacking regarding HIV/AIDS-related lymphoma (ARL) in India. Read More

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http://dx.doi.org/10.5045/br.2019.54.3.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779940PMC
September 2019

rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma.

BMJ Case Rep 2019 Sep 30;12(9). Epub 2019 Sep 30.

Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.

Patients with AIDS have increased risk of developing lymphomas, such as anaplastic large cell lymphoma (ALCL), which generally carry a poor prognosis. The genetic rearrangement in ALCL confers a favourable prognosis in HIV-negative patients; it is unknown how this interacts clinically with HIV/AIDS. A man aged 53 years presented with subcutaneous nodules on the scalp and axillae, and diffuse lymphadenopathy. Read More

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http://dx.doi.org/10.1136/bcr-2019-230641DOI Listing
September 2019
2 Reads

Plasmablastic lymphoma achieving sustained remission with antiretroviral therapy alone.

Eur J Haematol 2019 Dec 30;103(6):620-622. Epub 2019 Sep 30.

Department of Hematology-Oncology, University of Massachusetts Medical School-Baystate Medical Center, Springfield, Massachusetts.

Despite advances in the treatment of most human immunodeficiency virus (HIV)-related lymphomas, the outcomes for patients with HIV-related plasmablastic lymphoma (PBL) remain poor. While studies have shown an increased survival for patients with most kinds of HIV-related lymphomas since the introduction of highly active antiretroviral therapy (HAART), the impact of HAART on survival in patients with HIV-related PBL is unclear, mainly because the condition is rare and the number of published studies is small. Few case reports have shown regression of PBL after initiation of HAART, however, usually followed by recurrence of PBL or achieved with a need for chemotherapy. Read More

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http://dx.doi.org/10.1111/ejh.13326DOI Listing
December 2019
5 Reads

Patients With Malignant Lymphoma and HIV Infection Experiencing Remission After First-Line Treatment Have an Excellent Prognosis.

Clin Lymphoma Myeloma Leuk 2019 10 30;19(10):e581-e587. Epub 2019 May 30.

Department of Hematology, Oncology and Rheumatology, Heidelberg University, Heidelberg, Germany.

Background: Malignant lymphoma is still the leading cause of death among AIDS-related diseases.

Patients And Methods: We performed a retrospective analysis of 50 HIV-positive lymphoma patients. The median interval between HIV and malignant lymphoma diagnosis was 4 years. Read More

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http://dx.doi.org/10.1016/j.clml.2019.05.019DOI Listing
October 2019
3 Reads

Human Immunodeficiency Virus-Associated Lymphoproliferative Disorders.

Surg Pathol Clin 2019 Sep 17;12(3):771-782. Epub 2019 May 17.

Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, CB #7525, Chapel Hill, NC 27599-7525, USA. Electronic address:

HIV infection is associated with an increased risk for developing B-cell lymphoproliferative disorders. The spectrum of disease differs in HIV-infected versus HIV-uninfected persons, with aggressive B-cell non-Hodgkin lymphomas constituting a higher proportion of all lymphoproliferative disorders in the HIV-positive population. Although antiretroviral therapy (ART) has significantly changed the landscape of lymphomas arising in HIV-infected persons, population growth and aging are reflected in the steady increase in non-AIDS-defining cancers. Read More

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http://dx.doi.org/10.1016/j.path.2019.03.005DOI Listing
September 2019
2 Reads

Pseudoplatelets and apoptosis in Burkitt lymphoma.

Authors:
Barbara J Bain

Am J Hematol 2019 10 10;94(10):1168-1169. Epub 2019 Aug 10.

Department of Haematology, St. Mary's Hospital and Centre for Haematology, St. Mary's Hospital campus of Imperial College Faculty of Medicine, St. Mary's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1002/ajh.25586DOI Listing
October 2019
4 Reads

HIV-related lymphomas in adults served in the public health network: An observational study.

Medicine (Baltimore) 2019 Jun;98(26):e16129

Aggeu Magalhães Institute, Oswaldo Cruz Foundation.

Individuals infected with human immunodeficiency virus (HIV) have higher morbidity and mortality due to cancer, which is the third most common cause of death in this group, despite the high effectiveness of antiretroviral therapy (ART). We describe the clinical and laboratory characteristics, initial staging and outcome of HIV-related lymphoma.We included 18 patients in the study, of whom 61. Read More

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http://dx.doi.org/10.1097/MD.0000000000016129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617433PMC
June 2019
7 Reads
5.723 Impact Factor

Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL.

Sci Rep 2019 06 28;9(1):9371. Epub 2019 Jun 28.

UCLA AIDS Institute, University of California, Los Angeles, California, USA.

The risk for non-Hodgkin lymphoma (NHL) is markedly increased in persons living with human immunodeficiency virus (HIV) infection, and remains elevated in those on anti-retroviral therapy (cART). Both the loss of immunoregulation of Epstein-Barr virus (EBV) infected cells, as well as chronic B-cell activation, are believed to contribute to the genesis of AIDS-related NHL (AIDS-NHL). However, the mechanisms that lead to AIDS-NHL have not been completely defined. Read More

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http://dx.doi.org/10.1038/s41598-019-45479-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599055PMC
June 2019
5 Reads

Utility of fine-needle aspiration cytology in the diagnosis of HIV lymphadenopathy.

Diagn Cytopathol 2019 Oct 17;47(10):1011-1017. Epub 2019 Jun 17.

Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background: India, being a developing country, harbors the third largest human immunodeficiency virus (HIV)-infected population in the world, and HIV-associated lymphadenopathy is commonly encountered. HIV lymphadenopathy is more commonly generalized and pathology ranges from reactive lymphoid hyperplasia to infections like tuberculosis to neoplasms such as lymphoma and Kaposi sarcoma. The study intended to assess the utility of fine-needle aspiration (FNA) cytology in HIV lymphadenopathy. Read More

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http://dx.doi.org/10.1002/dc.24255DOI Listing
October 2019
12 Reads

The current state of human immunodeficiency virus-associated lymphoma in Japan: a nationwide retrospective study of the Japanese Society of Hematology Blood Disease Registry.

Int J Hematol 2019 Aug 20;110(2):244-249. Epub 2019 May 20.

Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, 860-8556, Kumamoto, Japan.

This retrospective nationwide study sought to clarify the current status of human immunodeficiency virus (HIV)-associated lymphoma in Japan, where the number of new HIV infections remains high. We extracted data of patients with HIV-associated lymphoma who were registered in the database of the Japanese Society of Hematology Blood Disease Registry from January 2012 to December 2015, and analyzed patient characteristics, pathological diagnosis, and outcomes. The study cohort included 79 patients, including 75 male patients, with a median age of 52. Read More

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http://dx.doi.org/10.1007/s12185-019-02668-0DOI Listing
August 2019
6 Reads

[Clinicopathological features of intestinal mucosal lesions in AIDS patients and their relation with CD4+ T lymphocytes].

Zhonghua Bing Li Xue Za Zhi 2019 May;48(5):378-384

Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing Institute of Infectious Diseases of Combined Chinese Traditional and Western Medicine, Beijing 100015, China.

To observe the histopathological features of different opportunistic infections and tumors of the intestinal mucosa in AIDS patients, and to explore the correlation between different lesions and CD4+ T lymphocyte levels. Colonic mucosal biopsy specimens of 263 patients with clinically diagnosed AIDS and abdominal pain, diarrhea, blood in the stool and other gastrointestinal symptoms were collected from Beijing Ditan Hospital from 2010 to 2018. There were 232 males and 31 females, with age range 10-81 (mean 40±13) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.05.009DOI Listing
May 2019
8 Reads

HIV-attributable causes of death in the medical ward at the Chris Hani Baragwanath Hospital, South Africa.

PLoS One 2019 6;14(5):e0215591. Epub 2019 May 6.

South African Centre for Epidemiological Modelling and Analysis, Stellenbosch University, Stellenbosch, South Africa.

Introduction: Data on the association between HIV infection and deaths from underlying medical conditions are needed to understand and assess the impact of HIV on mortality. We present data on mortality in the Chris Hani Baragwanath Hospital (CHBH) South Africa and analyse the relationship between each cause of death and HIV.

Methods: From 2006 to 2009 data were collected on 15,725 deaths including age, sex, day of admittance and of death, HIV status, ART initiation and CD4+ cell counts. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215591PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502348PMC
January 2020
5 Reads

Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3.

J Acquir Immune Defic Syndr 2019 07;81(3):266-273

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.

Background: We hypothesized that carriage of presumably high Hsp70-producing gene variants on a specific human major histocompatibility complex haplotype, the 8.1 ancestral haplotype (8.1AH), may predispose HIV-infected individuals to AIDS-non-Hodgkin lymphoma (NHL). Read More

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http://Insights.ovid.com/crossref?an=00126334-900000000-9642
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http://dx.doi.org/10.1097/QAI.0000000000002027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587227PMC
July 2019
14 Reads

Chronic cough and cystic lung disease caused by in a patient with AIDS.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Pulmonary and Critical Care Medicine, University of Maryland Medical Center, Baltimore, Maryland, USA.

A 24-year-old man with a history of HIV and large B cell lymphoma (currently in remission) presented with fever, dry cough and dizziness. His CD4+ count was undetectable, and the HIV viral load was 109 295 cop/mL. Physical examination revealed fever, hypotension and tachycardia with coarse breath sounds in the middle and lower chest zones bilaterally. Read More

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http://dx.doi.org/10.1136/bcr-2018-228741DOI Listing
April 2019
22 Reads

Optimizing treatment of HIV-associated lymphoma.

Authors:
Ariela Noy

Blood 2019 10;134(17):1385-1394

Cancer is the leading cause of death for HIV-infected persons in economically developed countries, even in the era of antiretroviral therapy (ART). Lymphomas remain a leading cause of cancer morbidity and mortality for HIV-infected patients and have increased incidence even in patients optimally treated with ART. Even limited interruptions of ART can lead to CD4 cell nadirs and HIV viremia, and increase the risk of lymphoma. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-01
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http://dx.doi.org/10.1182/blood-2018-01-791400DOI Listing
October 2019
8 Reads

The clinical features and prognosis of 100 AIDS-related lymphoma cases.

Sci Rep 2019 03 29;9(1):5381. Epub 2019 Mar 29.

Department of Medical Oncology, Henan Provincial Infectious Disease Hospital, Zhengzhou, Henan, 450015, China.

To improve outcomes and risk assessment, we systematically analyzed the clinical features of patients with acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL) and identified survival-associated factors. Data were collected from 100 patients diagnosed with ARL at the Henan Provincial Infectious Disease Hospital in China. The progression-free survival (PFS) duration and 2-year overall survival (OS) rate were determined. Read More

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http://dx.doi.org/10.1038/s41598-019-41869-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441082PMC
March 2019
8 Reads

Activity of brentuximab vedotin in AIDS-related primary effusion lymphoma.

Blood Adv 2019 03;3(5):766-768

Division of Hematology/Oncology, UC San Diego Moores Cancer Center, La Jolla, CA.

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http://dx.doi.org/10.1182/bloodadvances.2018026351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418491PMC
March 2019
7 Reads

Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication.

Sci Rep 2019 02 20;9(1):2372. Epub 2019 Feb 20.

Korea Zoonosis Research Institute, Chonbuk National University, Iksan-Si, Chollabuk-do, 54531, Republic of Korea.

Kaposi's sarcoma-associated herpesvirus (KSHV) is causally associated with several malignant tumors: Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). KS remains the most common AIDS-related malignancy since the AIDS epidemic and thus has been extensively studied. KS is characterized as an angioproliferative disease with massive immune cell infiltration at the early stage. Read More

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http://www.nature.com/articles/s41598-019-38870-7
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http://dx.doi.org/10.1038/s41598-019-38870-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382833PMC
February 2019
10 Reads

AIDS-Related Kaposi Sarcoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2019 02;17(2):171-189

National Comprehensive Cancer Network.

As treatment of HIV has improved, people living with HIV (PLWH) have experienced a decreased risk of AIDS and AIDS-defining cancers (non-Hodgkin's lymphoma, Kaposi sarcoma, and cervical cancer), but the risk of Kaposi sarcoma in PLWH is still elevated about 500-fold compared with the general population in the United States. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for AIDS-Related Kaposi Sarcoma provide diagnosis, treatment, and surveillance recommendations for PLWH who develop limited cutaneous Kaposi sarcoma and for those with advanced cutaneous, oral, visceral, or nodal disease. Read More

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http://dx.doi.org/10.6004/jnccn.2019.0008DOI Listing
February 2019
15 Reads
4.178 Impact Factor

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
June 2019
8 Reads

Hiv and Lymphoma: from Epidemiology to Clinical Management.

Mediterr J Hematol Infect Dis 2019 1;11(1):e2019004. Epub 2019 Jan 1.

Ematologia, Spedali Civili di Brescia.

Patients infected with human immunodeficiency virus (HIV) are at increased risk for developing both non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). Even if this risk has decreased for NHL after the introduction of combination antiretroviral therapy (cART), they remain the most common acquired immune deficiency syndrome (AIDS)-related cancer in the developed world. They are almost always of B-cell origin, and some specific lymphoma types are more common than others. Read More

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https://www.mjhid.org/index.php/mjhid/article/view/2019.004
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http://dx.doi.org/10.4084/MJHID.2019.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328036PMC
January 2019
29 Reads

A decade of antiretroviral therapy in Uganda: what are the emerging causes of death?

BMC Infect Dis 2019 Jan 21;19(1):77. Epub 2019 Jan 21.

Research Department, Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: The roll out of antiretroviral therapy (ART) in Sub-Saharan Africa led to a decrease in mortality. Few studies have documented the causes of deaths among patients on long term antiretroviral therapy in Sub-Saharan Africa. Our objective was to describe the causes of death among patients on long term ART in Sub-Saharan Africa. Read More

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http://dx.doi.org/10.1186/s12879-019-3724-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341568PMC
January 2019
24 Reads

Highly Active Antiretroviral Therapy and Gamma Knife Radiosurgery for the Treatment of AIDS-Related Primary Central Nervous System Lymphoma: A Case Report.

World Neurosurg 2019 Jan 14. Epub 2019 Jan 14.

Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, Spain.

A 66-year-old male presented with acute cephalalgia, disorientation, and lethargy. The patient was evaluated in the ER and admitted with probable hydrocephalus. Brain-MRI revealed multiple nonspecific brain lesions, predominantly involving the right temporal lobe, which on biopsy proved a diagnosis of Primary Central Nervous System Lymphoma (PCNSL). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193005
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http://dx.doi.org/10.1016/j.wneu.2018.12.182DOI Listing
January 2019
32 Reads
2.417 Impact Factor

Letter to the editors regarding the paper: Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience.

Infect Agent Cancer 2018 11;13:39. Epub 2018 Dec 11.

1Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, 2 Alameda San Marcos Avenue, Chorrillos, 15067 Lima, Peru.

Non-Hodgkin Lymphoma (NHL) is a neoplasm associated with a group of malignancies called AIDs-Defining Malignancies (ADMs) in Human-Immunodeficiency Virus (HIV) -patients. Similar to the case of NHL in Latin America, particularly in Peru, the amount of research done on others ADMs is limited, especially in the case of Kaposi's Sarcoma (KS). Prior investigations have talked about the great potential risk that represents this illness in latin american population, but topics as prognosis factors are yet to be well defined. Read More

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http://dx.doi.org/10.1186/s13027-018-0213-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288895PMC
December 2018
9 Reads

Molecular Biology of EBV in Relationship to HIV/AIDS-Associated Oncogenesis.

Cancer Treat Res 2019;177:81-103

Department of Otorhinolaryngology-Head and Neck Surgery and Tumor Virology and Global Cancer Programs, Abramson Cancer Center, Philadelphia, USA.

Herpesvirus-induced disease is one of the most lethal factors which leads to high mortality in HIV/AIDS patients. EBV, also known as human herpesvirus 4, can transform naive B cells into immortalized cells in vitro through the regulation of cell cycle, cell proliferation, and apoptosis. EBV infection is associated with several lymphoma and epithelial cancers in humans, which occurs at a much higher rate in immune deficient individuals than in healthy people, demonstrating that the immune system plays a vital role in inhibiting EBV activities. Read More

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http://link.springer.com/10.1007/978-3-030-03502-0_4
Publisher Site
http://dx.doi.org/10.1007/978-3-030-03502-0_4DOI Listing
June 2019
37 Reads

AIDS-Associated Malignancies.

Cancer Treat Res 2019;177:1-21

Department of Dermatology, University of Texas Health Sciences Center at Houston, Houston, TX, 77030, USA.

Malignancies were one of the earliest recognized manifestations that led to the description of the acquired immune deficiency syndrome (AIDS). The majority of cancers in AIDS patients are associated with coinfection with oncogenic viruses, such as Epstein-Barr virus, human herpesvirus 8, and human papillomavirus, with resulting malignancies occurring secondary to diminished immune surveillance against viruses and virus-infected tumor cells. Over 50% of AIDS lymphomas are associated with Epstein-Barr virus (EBV) and/or HHV8 infection. Read More

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http://dx.doi.org/10.1007/978-3-030-03502-0_1DOI Listing
June 2019
15 Reads

Serological Assessment of 18 Pathogens and Risk of AIDS-Associated Non-Hodgkin Lymphoma.

J Acquir Immune Defic Syndr 2019 03;80(3):e53-e63

Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.

Background: HIV infection is associated with increased susceptibility to common pathogens, which may trigger chronic antigenic stimulation and hyperactivation of B cells, events known to precede the development of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL).

Methods: To explore whether cumulative exposure to infectious agents contributes to AIDS-NHL risk, we tested sera from 199 AIDS-NHL patients (pre-NHL, average lead time 3.9 years) and 199 matched HIV-infected controls from the Multicenter AIDS Cohort Study, for anti-IgG responses to 18 pathogens using multiplex serology. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375787PMC
March 2019
25 Reads

Nivolumab as a safe and effective treatment in an HIV patient with refractory Hodgkin lymphoma.

Ann Hematol 2019 Jun 9;98(6):1505-1506. Epub 2018 Nov 9.

Department of Cellular Biotecnologies and Hemathology, Sapienza University of Rome, Via Benevento 6, 00161, Rome, Italy.

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http://link.springer.com/10.1007/s00277-018-3541-0
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http://dx.doi.org/10.1007/s00277-018-3541-0DOI Listing
June 2019
12 Reads

A longitudinal and cross-sectional study ofEpstein-Barr virus DNA load: a possible predictor of AIDS-related lymphoma in HIV-infected patients.

Infect Dis (Lond) 2018 Nov - Dec;50(11-12):847-852. Epub 2018 Oct 14.

a Department of Internal Medicine and Infectious Diseases , Erasmus Medical Center , Rotterdam , The Netherlands.

Introduction: HIV-infected patients are more than 100-fold greater at risk for developing malignant AIDS-related lymphoma (ARL) compared to the general population. Most ARLs are EBV related. The main purpose of this study was to investigate whether a high peak EBV DNA load in HIV-infected patients is predictive of ARL, including classical Hodgkin lymphoma. Read More

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https://www.tandfonline.com/doi/full/10.1080/23744235.2018.1
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http://dx.doi.org/10.1080/23744235.2018.1508884DOI Listing
April 2019
11 Reads

Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana.

J Glob Oncol 2018 09;4:1-11

Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC.

Purpose: Botswana has a high prevalence of HIV infection. Currently, there are few data regarding the sociodemographic factors, clinical characteristics, and outcomes of non-Hodgkin lymphoma (NHL)-an AIDS-defining cancer-in the country.

Patients And Methods: This study used a prospective cancer registry to identify patients with a new diagnosis of NHL reporting for specialty cancer care at three hospitals in Botswana between October 2010 and August 2016. Read More

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http://dx.doi.org/10.1200/JGO.17.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223476PMC
September 2018
27 Reads

Molecular Diagnostics for AIDS Lymphoma Diagnosis in South Africa and the Potential for Other Low- and Middle-Income Countries.

J Glob Oncol 2018 09 25;4:1-6. Epub 2017 Aug 25.

Samantha L. Vogt and Richard Ambinder, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Moosa Patel, Tanvier Omar, and Sugeshnee Pather, University of the Witwatersrand, Johannesburg; and Neil Martinson, Perinatal HIV Research Unit, Soweto, South Africa.

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http://dx.doi.org/10.1200/JGO.17.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180762PMC
September 2018
4 Reads

Malignancy Trends in HIV-Infected Patients Over the Past 10 Years in a Single-Center Retrospective Observational Study in the United States.

Cancer Control 2018 Jan-Dec;25(1):1073274818797955

6 Infectious Diseases and Hospital Epidemiologist, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

The introduction of antiretroviral therapy (ART) in 1995 had a dramatic impact on the morbidity and mortality of the HIV population, and subsequently, the natural history of cancer has changed. The purpose of our study was to review the prevalence of AIDS-defining malignancies and non-AIDS defining cancers (NADC), taking into consideration racial and gender variations. After the institutional review board approval, the study was conducted as a retrospective chart review of 279 HIV-infected patients who were treated at the Moffitt Cancer Center between January 1, 2000 and December 31, 2010. Read More

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http://dx.doi.org/10.1177/1073274818797955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128080PMC
December 2018
23 Reads

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

PLoS Pathog 2018 07 27;14(7):e1007179. Epub 2018 Jul 27.

Department of Oncology in Wisconsin Institutes for Medical Research, McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.

Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell malignancies. However, whether lytic EBV infection also contributes to tumors is unclear, although the association between malaria infection and Burkitt lymphomas (BLs) may involve excessive lytic EBV replication. A particular variant of the viral promoter (Zp) that controls lytic EBV reactivation is over-represented, relative to its frequency in non-malignant tissue, in EBV-positive nasopharyngeal carcinomas and AIDS-related lymphomas. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082571PMC
July 2018
13 Reads

Incidence of Hodgkin lymphoma in HIV-positive and HIV-negative patients at a tertiary hospital in South Africa (2005 - 2016) and comparison with other African countries.

S Afr Med J 2018 Jun 26;108(7):653-567. Epub 2018 Jun 26.

Division of Haematopathology, Department of Pathology, National Health Laboratory Service and Stellenbosch University, Cape Town, South Africa.

Background: Hodgkin lymphoma (HL) is the most common non-AIDS-defining cancer in HIV-positive patients. Studies on South African (SA) populations have described the prevalence as 7 - 17% of all lymphomas, 8 - 27% of head and neck lymphomas, 9% of lymph node biopsies and 4% of HIV-related malignancies.

Objectives: To describe the incidence of HL at our centre between 2005 and 2016 by year, gender, HIV status, histological subclassification and bone marrow involvement, and compare these findings with similar SA and African studies. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i7.12844DOI Listing
June 2018
14 Reads

The role of brain biopsy in the clinical management of HIV-related focal brain lesions.

HIV Med 2018 11 13;19(10):673-678. Epub 2018 Jul 13.

HIV Unit, JM Ramos Mejía Hospital, Buenos Aires, Argentina.

Objectives: Up to 20% of HIV-related focal brain lesion (FBL) diagnoses cannot be determined without invasive procedures. In such cases, brain biopsy is an important step in the evaluation algorithm. The aims of this study were to describe the clinical outcomes of patients with FBL, the proportion of diagnoses confirmed by brain biopsies and their aetiologies, and to analyse the proportion of patients in whom the biopsy motivated a change in therapeutic management. Read More

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http://dx.doi.org/10.1111/hiv.12646DOI Listing
November 2018
7 Reads

Plasma Epstein-Barr Virus Load as an Early Biomarker and Prognostic Factor of Human Immunodeficiency Virus-related Lymphomas.

Clin Infect Dis 2019 02;68(5):834-843

Department of Hematology, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona.

Background: Epstein-Barr virus (EBV) has been implicated in lymphomagenesis and can be found infecting tumor cells and in plasma at lymphoma diagnosis, especially in human immunodeficiency virus (HIV)-infected patients. Our aim was to evaluate the usefulness of plasma EBV load as biomarker and prognostic factor in HIV-positive patients with lymphomas.

Methods: EBV loads were measured by polymerase chain reaction in plasma samples of 81 HIV-positive patients' lymphomas at different moments: within 1 year before lymphoma diagnosis, at diagnosis, and at complete response (CR). Read More

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http://dx.doi.org/10.1093/cid/ciy542DOI Listing
February 2019
81 Reads