272 results match your criteria AIDS research and treatment[Journal]


Healthcare Workers' Perspectives on the Barriers to Providing HIV Services to Children in Sub-Saharan Africa.

AIDS Res Treat 2019 3;2019:8056382. Epub 2019 Mar 3.

Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

Background: In order to accelerate the HIV response to meet the UNAIDS 90-90-90 indicators for children, healthcare workers need to lead a scale-up of HIV services in primary healthcare settings. Such a scale-up will require investigation into existing barriers that prevent healthcare workers from effectively providing those services to children. Furthermore, if the identified barriers are not well understood, designing context-specific and effective public health response programmes may prove difficult. Read More

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http://dx.doi.org/10.1155/2019/8056382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421001PMC
March 2019
8 Reads

Primary HIV Drug Resistance among Recently Infected Cases of HIV in North-West India.

AIDS Res Treat 2019 27;2019:1525646. Epub 2019 Feb 27.

Department of Community Medicine and School of Public Health, Post-Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

Background: Antiretroviral treatment may lead to the emergence of HIV drug resistance, which can be transmitted. HIV primary drug resistance (PDR) is of great public health concern because it has the potential to compromise the efficacy of antiretroviral therapy (ART) at the population level.

Objective: To estimate the level of primary drug resistance among recently infected cases of HIV in 6 ART centres of North-Western India from September 2014 to June 2016. Read More

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http://dx.doi.org/10.1155/2019/1525646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415312PMC
February 2019
4 Reads

Knowledge, Attitude, and Practice of Postexposure Prophylaxis against HIV Infection among Healthcare Workers in Hiwot Fana Specialized University Hospital, Eastern Ethiopia.

AIDS Res Treat 2019 21;2019:7947086. Epub 2019 Feb 21.

Department of Clinical Nursing, College of Medicine and Health Science, Jigjiga University, Jigjiga, Ethiopia.

Background: Postexposure chemoprophylaxis can prevent human immunodeficiency virus (HIV) infection in risk health care workers; however routine adoption of these practices by the workers has been limited.

Methods: A cross-sectional study was conducted on 311 health care workers of Hiwot Fana Specialized University Hospital between February and March 2016. Data was collected using a structured self-administered questionnaire and analysed using STATA 12. Read More

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http://dx.doi.org/10.1155/2019/7947086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409033PMC
February 2019

Prevalence of Depressive Symptoms and Associated Factors among HIV-Positive Youth Attending ART Follow-Up in Addis Ababa, Ethiopia.

AIDS Res Treat 2019 2;2019:4610458. Epub 2019 Jan 2.

Department of Epidemiology, Jimma University, Jimma, Ethiopia.

Depression is most frequently and highly occurring common mental disorder in HIV/AIDS patients especially youth living with HIV/AIDS. This study aimed to assess the prevalence and associated factors of depressive symptoms among youth living with Human Immunodeficiency Virus (HIV) attending Antiretroviral Therapy (ART) follow-up at public hospitals in Addis Ababa, Ethiopia. . Read More

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http://dx.doi.org/10.1155/2019/4610458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334359PMC
January 2019
1 Read

Coping Strategies for Adverse Effects of Antiretroviral Therapy among Adult HIV Patients Attending University of Gondar Referral Hospital, Gondar, Northwest Ethiopia: A Cross-Sectional Study.

AIDS Res Treat 2018 2;2018:1879198. Epub 2018 Dec 2.

Department of Pharmacy, College of Medicine and Health Science, Ambo University, P.O. Box 19, Ambo, Ethiopia.

Background: Adverse effects from antiretroviral therapy (ART) have an impact on quality of life and medication adherence. There is no clear understanding of how people manage the adverse effects of ART. The individual taking medications which cause serious adverse effects may choose to stop or reduce the medications to relieve the adverse effects. Read More

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https://www.hindawi.com/journals/art/2018/1879198/
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http://dx.doi.org/10.1155/2018/1879198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304486PMC
December 2018
8 Reads

Sexual Behavior of Perinatally Infected Youth in Northwest Ethiopia: Implication for HIV Prevention Strategy.

AIDS Res Treat 2018 1;2018:1573845. Epub 2018 Nov 1.

Public Health Department, Medicine and Health Sciences College, Debre Markos University, Debre Markos, Ethiopia.

Background: The major mode of HIV transmission in many resource-limited settings is via heterosexual intercourse, but the primary risk factor for youth is primarily through perinatal infection. With the maturing of the HIV epidemic, youth who acquired the virus perinatally are now reaching adolescence and becoming young adults. There is a paucity of data on the sexual practices of perinatally infected youth in Ethiopia. Read More

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https://www.hindawi.com/journals/art/2018/1573845/
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http://dx.doi.org/10.1155/2018/1573845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236663PMC
November 2018
17 Reads

Pediatric HIV Disclosure in Northern India: Evaluation of Its Prevalence, Perceptions amongst Caregivers, and Its Impact on CLHIV.

AIDS Res Treat 2018 24;2018:2840467. Epub 2018 Oct 24.

Department of Pediatrics, Post Graduate Institute of Medical Education & Research and Dr. Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi 110001, India.

Background: With improving standards of care of children living with HIV (CLHIV), pediatric HIV related mortality rates are declining. New challenges like HIV status disclosure are emerging which need to be addressed to ensure their smooth transition into adulthood. Poor disease disclosure rates are observed in CLHIV globally. Read More

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http://dx.doi.org/10.1155/2018/2840467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220414PMC
October 2018

Early Infant Diagnosis Sample Management in Mashonaland West Province, Zimbabwe, 2017.

AIDS Res Treat 2018 26;2018:4234256. Epub 2018 Jul 26.

Department of Community Medicine, University of Zimbabwe, Zimbabwe.

Background: In 2016, Mashonaland West Province had 7.4% (520) dried blood spot (DBS) samples for early infant diagnosis (EID) rejected by the Zimbabwe National Microbiology Reference Laboratory (NMRL). The samples were suboptimal, delaying treatment initiation for HIV-infected children. Read More

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http://dx.doi.org/10.1155/2018/4234256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083648PMC
July 2018
1 Read

Trauma and Growth: Impact of AIDS Activism.

AIDS Res Treat 2018 24;2018:9696725. Epub 2018 May 24.

Treatment Action Group, New York, NY, USA.

Introduction: Our goal was to assess the long-term impact of AIDS activism of ACT UP/New York on the current adjustment of those who were members during its peak years (1987-1992), including assessment of trauma sequelae as well as posttraumatic growth.

Methods: A 90-minute semistructured interview and 6 validated self-report scales were administered. We relied on purposive and snowball sampling to recruit potential participants. Read More

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http://dx.doi.org/10.1155/2018/9696725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994318PMC
May 2018
1 Read

Socioeconomic Status and Vulnerability to HIV Infection in Uganda: Evidence from Multilevel Modelling of AIDS Indicator Survey Data.

AIDS Res Treat 2018 7;2018:7812146. Epub 2018 Jun 7.

University of Hull, UK.

Background: There is controversy on the association between socioeconomic status (SES) and HIV infection. Some evidence claims higher SES is negatively associated with HIV infection while others report the reverse.

Objectives: To examine the association between SES and HIV infection in Uganda and to examine whether the SES-HIV relationship varies by gender, rural-urban place of residence, and time (2004-2005 and 2011) in Uganda. Read More

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http://dx.doi.org/10.1155/2018/7812146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011175PMC

Messaging Circumstances and Economic Pressures as Influences on Linkage to Medical Male Circumcision following Community-Based HIV Testing for Men in Rural Southwest Uganda: A Qualitative Study.

AIDS Res Treat 2018 3;2018:8387436. Epub 2018 May 3.

Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.

Voluntary medical male circumcision (MMC) reduces risk of HIV infection, but uptake remains suboptimal among certain age groups and locations in sub-Saharan Africa. We analysed qualitative data as part of the Linkages Study, a randomized controlled trial to evaluate community-based HIV testing and follow-up as interventions promoting linkage to HIV treatment and prevention in Uganda and South Africa. Fifty-two HIV-negative uncircumcised men participated in the qualitative study. Read More

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http://dx.doi.org/10.1155/2018/8387436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960566PMC
May 2018
7 Reads

Reproduction and Fertility Beliefs, Perceptions, and Attitudes in People Living with HIV.

AIDS Res Treat 2018 1;2018:5349793. Epub 2018 Apr 1.

Section on Infectious Diseases, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

People living with HIV (PLWH) have distinct needs when it comes to reproductive health, specifically regarding fertility, family planning, and pregnancy, and these needs are often complicated by HIV status. While there is ample research that focuses on reproductive health in PLWH through a quantitative lens, there is a lack of research using qualitative methods, namely, the narrative interview model. We searched PubMed and relevant abstracts to identify 72 articles published from 1997 to 2016 that described a qualitative framework for exploring the behaviors and perceptions regarding family planning, abortion, pregnancy, parenthood, fertility, and forced sterility in PLWH. Read More

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http://dx.doi.org/10.1155/2018/5349793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899855PMC

Childhood Adversities and Physical and Mental Health Outcomes in Adults Living with HIV: Findings from the Ontario HIV Treatment Network Cohort Study.

AIDS Res Treat 2018 1;2018:2187232. Epub 2018 Mar 1.

Ontario HIV Treatment Network, Toronto, ON, Canada.

We sought to estimate the prevalence of childhood adversity and examine its relationship with health outcomes among people living with HIV. Study participants included 1409 adults living with HIV and receiving care in Toronto, Canada. Data on childhood adversity, health behaviors, HIV outcome measures, depression, and health-related quality of life (HRQOL) were collected through face-to-face interviews and medical records. Read More

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http://dx.doi.org/10.1155/2018/2187232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852860PMC
March 2018
5 Reads

Prevalence and Associated Factors of Depression among PLHIV in Ethiopia: Systematic Review and Meta-Analysis, 2017.

AIDS Res Treat 2018 28;2018:5462959. Epub 2018 Feb 28.

Department of Psychiatry, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: Depression is a substantial contributor to the global burden of disease and affects people in all communities across the globe. Depression is the most common psychiatric problem associated with HIV/AIDS and half of all PLWHIV with depression go underdiagnosed and untreated. Psychiatric complications of HIVAIDS delay mental health services in less affluent countries. Read More

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https://www.hindawi.com/journals/art/2018/5462959/
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http://dx.doi.org/10.1155/2018/5462959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850898PMC
February 2018
3 Reads

The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation.

AIDS Res Treat 2018 17;2018:5908167. Epub 2018 Jan 17.

PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA.

Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissolving tablets (FDTs) containing a fixed-dose combination of lopinavir and ritonavir (LPV/r). Consumption patterns of solutions during brief-access and long-term testing and baby foodstuff consumption were analyzed to evaluate the orosensory detection and avoidance of placebo FDTs containing no LPV/r (FDT-) and FDTs containing LPV/r (FDT+). Read More

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http://dx.doi.org/10.1155/2018/5908167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822810PMC
January 2018
7 Reads

Nasal Nitric Oxide Levels in HIV Infection: A Cross-Sectional Study.

AIDS Res Treat 2018 9;2018:7645125. Epub 2018 Jan 9.

Division of Pediatric Respiratory Medicine, McGill University Health Center Research Institute, Montreal, QC, Canada.

Introduction: Low levels of nasal NO have been associated with increased propensity to rhinosinusitis and respiratory tract infections. Our objective was to describe nasal NO levels in HIV-infected individuals versus healthy controls and determine possible risk factors for reduced nasal NO levels.

Materials And Methods: HIV-infected individuals and healthy controls were recruited. Read More

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http://dx.doi.org/10.1155/2018/7645125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818882PMC
January 2018
17 Reads

HIV-Stigma in Nigeria: Review of Research Studies, Policies, and Programmes.

AIDS Res Treat 2017 27;2017:5812650. Epub 2017 Dec 27.

Demography and Population Studies Programme, Schools of Public Health and Social Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Nigeria has about 3.8 million people living with HIV, the second largest globally. Stigma and discrimination are major barriers to testing, treatment uptake, and adherence. Read More

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http://dx.doi.org/10.1155/2017/5812650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763061PMC
December 2017

Assessing Very Early Infant Diagnosis Turnaround Times: Findings from a Birth Testing Pilot in Lesotho.

AIDS Res Treat 2017 19;2017:2572594. Epub 2017 Dec 19.

Elizabeth Glaser Pediatric AIDS Foundation, Project SOAR (Supporting Operational AIDS Research), Washington, DC, USA.

Very early infant diagnosis (VEID) (testing within two weeks of life), combined with rapid treatment initiation, could reduce early infant mortality. Our study evaluated turnaround time (TAT) to receipt of infants' HIV test results and ART initiation if HIV-infected, with and without birth testing availability. Data from facility records and national databases were collected for 12 facilities offering VEID, as part of an observational prospective cohort study, and 10 noncohort facilities. Read More

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http://dx.doi.org/10.1155/2017/2572594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749171PMC
December 2017
5 Reads

Challenges in Assessing Outcomes among Infants of Pregnant HIV-Positive Women Receiving ART in Uganda.

AIDS Res Treat 2017 7;2017:3202737. Epub 2017 Dec 7.

Infectious Diseases Institute, Makerere University, Kampala, Uganda.

Since 2012, the WHO recommends lifelong ART with TDF+FTC/3TC+EFV for all HIV-positive pregnant and breastfeeding women (Option B-plus). In this analysis we describe the proportion of early and late transmission in mothers with high retention in Kampala, Uganda. We included 700 pregnant women from January 2012 to August 2014 with a follow-up extended to August 2016; the median age was 31 years (IQR: 26-35), 36. Read More

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http://dx.doi.org/10.1155/2017/3202737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738585PMC
December 2017
1 Read

HIV among Female Sex Workers in Five Cities in Burkina Faso: A Cross-Sectional Baseline Survey to Inform HIV/AIDS Programs.

AIDS Res Treat 2017 15;2017:9580548. Epub 2017 Nov 15.

Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, West Africa, Burkina Faso.

Background: Female sex workers (FSWs) are considered a vulnerable population for HIV infection and a priority for HIV/AIDS response programs. This study aimed to determine HIV prevalence among FSWs in five cities in Burkina Faso.

Methods: FSWs aged 18 and older were recruited using respondent driven sampling (RDS) in five cities (Ouagadougou, Bobo-Dioulasso, Koudougou, Ouahigouya, and Tenkodogo) in Burkina Faso from 2013 to 2014. Read More

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https://www.hindawi.com/journals/art/2017/9580548/
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http://dx.doi.org/10.1155/2017/9580548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705869PMC
November 2017
20 Reads

Conceptualising the Factors Affecting Retention in Care of Patients on Antiretroviral Treatment in Kabwe District, Zambia, Using the Ecological Framework.

AIDS Res Treat 2017 9;2017:7356362. Epub 2017 Nov 9.

School of Public Health, University of the Western Cape, Cape Town, South Africa.

Background: HIV remains a major public health challenge in Zambia. The roll-out of antiretroviral treatment (ART) has engendered new challenges in retention in care.

Objective: To conceptualise the factors affecting retention in care of ART patients at three primary healthcare facilities using the ecological framework. Read More

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http://dx.doi.org/10.1155/2017/7356362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700481PMC
November 2017
18 Reads

Mortality and Its Predictors among HIV Infected Patients Taking Antiretroviral Treatment in Ethiopia: A Systematic Review.

AIDS Res Treat 2017 30;2017:5415298. Epub 2017 Oct 30.

Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Even though the benefit of antiretroviral therapy (ART) is well established, there is a regional variation in the extent of its benefit. The aim of this review is to highlight mortality and its predictors in Ethiopian adult HIV patients who were on ART.

Methods: Relevant articles were searched on PubMed and Google Scholar databases. Read More

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http://dx.doi.org/10.1155/2017/5415298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682904PMC
October 2017
3 Reads

Disclosure of Parental HIV Status to Children: Experiences of Adults Receiving Antiretroviral Treatment at an Urban Clinic in Kampala, Uganda.

AIDS Res Treat 2017 25;2017:3458684. Epub 2017 Oct 25.

Department of Internal Medicine, School of Medicine, Makerere College of Health Sciences, P.O. Box 7072, Kampala, Uganda.

Limited data are available on the experiences of parental HIV disclosure to children in Uganda. We conducted a qualitative study comprising sixteen in-depth interviews and four focus group discussions with parents receiving highly active antiretroviral therapy. Analysis was done using Atlas. Read More

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http://dx.doi.org/10.1155/2017/3458684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676343PMC
October 2017
3 Reads

Quality of Life of People Living with HIV/AIDS in the Ho Municipality, Ghana: A Cross-Sectional Study.

AIDS Res Treat 2017 24;2017:6806951. Epub 2017 Oct 24.

Laboratory Department, Volta Regional Hospital, Ghana Health Service, Ho, Volta Region, Ghana.

Quality of life (QoL) is an important component in the evaluation of the wellbeing of people living with HIV/AIDS (PLHIV). This study was aimed at evaluating the QoL of PLHIV attending the antiretroviral clinics in the Ho municipality. A cross-sectional study was conducted from January 2017 to April 2017 involving 158 purposively selected HIV-positive patients who were attending the antiretroviral clinics both in the Volta Regional Hospital and Ho Municipal Hospital. Read More

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http://dx.doi.org/10.1155/2017/6806951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674481PMC
October 2017
15 Reads

Early Diagnosis of HIV among Infants Born to HIV-Positive Mothers on Option-B Plus in Kampala, Uganda.

AIDS Res Treat 2017 19;2017:4654763. Epub 2017 Oct 19.

Department of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.

Introduction: Globally, there is delay in accessing early HIV diagnosis (EID) among HIV exposed infants (HEIs). With paucity of data on EID use at Kisenyi Health Center, this study assessed factors associated with EID use among HEIs (HIV exposed infants).

Method: This was a cross-sectional study of 246 HIV-positive mother-baby pairs. Read More

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http://dx.doi.org/10.1155/2017/4654763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671668PMC
October 2017
1 Read

Lipodystrophy among HIV-Infected Patients Attending Care and Treatment Clinics in Dar es Salaam.

AIDS Res Treat 2017 11;2017:3896539. Epub 2017 Oct 11.

Department of Behavioral Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

Background: HIV infection and long-term HAART use are associated with metabolic and morphological changes. We assessed prevalence, types, and risk factors associated with lipodystrophy among HIV-infected adults attending CTC in Dar es Salaam, Tanzania.

Methods: Analysis included 466 HIV-infected patients. Read More

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https://www.hindawi.com/journals/art/2017/3896539/
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http://dx.doi.org/10.1155/2017/3896539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660755PMC
October 2017
10 Reads

HIV Case Management Support Service Is Associated with Improved CD4 Counts of Patients Receiving Care at the Antiretroviral Clinic of Pantang Hospital, Ghana.

AIDS Res Treat 2017 20;2017:4697473. Epub 2017 Sep 20.

Division of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Factors associated with individual patient-level management of HIV have received minimal attention in sub-Saharan Africa. This study determined the association between support services and cluster of differentiation 4 (CD4) counts among HIV patients attending ART clinic in Ghana.

Methodology: This was a cross-sectional study involving adults with HIV recruited between 1 August 2014 and 31 January 2015. Read More

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http://dx.doi.org/10.1155/2017/4697473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632479PMC
September 2017
1 Read

Ritonavir-Boosted Darunavir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Other Regimens for Initial Antiretroviral Therapy for People with HIV Infection: A Systematic Review.

AIDS Res Treat 2017 26;2017:2345617. Epub 2017 Sep 26.

Global Health Sciences, University of California, San Francisco, San Francisco, CA, USA.

Background: Darunavir is a second-generation protease-inhibitor used with ritonavir (DRV/r) and two nucleoside reverse-transcriptase inhibitors as an option in first-line antiretroviral treatment (ART).

Methods: We systematically reviewed randomized controlled trials (RCTs) of DRV/r versus other regimens in patients initiating ART. We searched five bibliographic databases and other key resources. Read More

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http://dx.doi.org/10.1155/2017/2345617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634582PMC
September 2017
5 Reads

HIV Epidemic in Tanzania: The Possible Role of the Key Populations.

AIDS Res Treat 2017 17;2017:7089150. Epub 2017 Aug 17.

Department of Internal Medicine, School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

HIV remains a public health concern in Tanzania and other Eastern and Southern African countries. Estimates show that there were about 1.4 million people living with HIV in Tanzania in the year 2013. Read More

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http://dx.doi.org/10.1155/2017/7089150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602645PMC

Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering Ethinylestradiol/Levonorgestrel.

AIDS Res Treat 2017 31;2017:6531709. Epub 2017 Jul 31.

Department of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, P.O. Box 7062, Kampala, Uganda.

This study assessed the effect of efavirenz mid-dose plasma concentrations on mid-luteal endogenous progesterone concentrations and contraceptive outcomes among 49 HIV infected women coadministering ethinylestradiol/levonorgestrel, including 34 HIV positive women on Highly Active Antiretroviral Therapy (HAART) and 15 HAART naïve HIV infected women, purposively selected from Mulago Hospital, Uganda. A blood sample was collected once between days 20 and 22 of each woman's menstrual cycle for measuring endogenous progesterone and efavirenz concentrations by electrochemiluminescence technology and High Performance Liquid Chromatography (HPLC), respectively. Descriptive statistical analysis and correlation and logistic regression analysis were done using SPSS v. Read More

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http://dx.doi.org/10.1155/2017/6531709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555015PMC
July 2017
9 Reads

Missed Testing Opportunities for HIV Screening and Early Diagnosis in an Urban Tertiary Care Center.

AIDS Res Treat 2017 4;2017:5708620. Epub 2017 Jul 4.

Department of Medicine, Division of Infectious Diseases, Rutgers New Jersey Medical School, Newark, NJ, USA.

Newark, New Jersey, is disproportionally affected by HIV with one of the highest prevalence rates in the United States. Rutgers New Jersey Medical School is a major healthcare provider to Newark's underserved population and has implemented a HIV testing program that can diagnose and link newly diagnosed individuals to care. We conducted a retrospective chart review of all new patients seen in the Infectious Disease Practice from January 1, 2013, to December 31, 2014, to determine the proportion of patients with a missed testing opportunity (MTO) (patients with a new HIV diagnosis with an encounter at the institution in the 1 year prior to their first appointment). Read More

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http://dx.doi.org/10.1155/2017/5708620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514340PMC

Prevalence and Clinical Spectrum of Liver Disease in Nepalese HIV-Sero-Positive Patients Undergoing Antiretroviral Therapy: A Cross-Sectional Hospital Based Study.

AIDS Res Treat 2017 11;2017:3134790. Epub 2017 Jun 11.

Faculty of Pharmaceutical Science, Purbanchal University, Little Buddha College of Health Science, Minbhawan, Kathmandu, Nepal.

Introduction: Liver enzyme abnormalities are common in HIV patients, and the prevalence varies across the nations. In Nepal, however, prevalence of liver enzyme disorder and the spectrum of these populations are lacking.

Objective: The present study sheds light on prevalence and clinical spectrum of liver disease in Nepalese HIV-sero-positive patients. Read More

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http://dx.doi.org/10.1155/2017/3134790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485296PMC
June 2017
6 Reads

Incidence and Predictors of Pregnancy among Women on ART in Debre Markos Referral Hospital, Northwest Ethiopia: .

AIDS Res Treat 2017 5;2017:3261205. Epub 2017 Jun 5.

Ethiopian Public Health Association, Addis Ababa, Ethiopia.

Globally, death of women due to HIV/AIDS related causes during pregnancy or within 42 days after pregnancy was estimated to be 37,000. In Ethiopia, 42,900 pregnant women living with HIV gave birth in the year 2011. This study was aimed to assess incidence and predictors of pregnancy among women on ART in Debre Markos Referral Hospital, Northwest Ethiopia. Read More

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http://dx.doi.org/10.1155/2017/3261205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474550PMC
June 2017
7 Reads

Efficacy and Tolerability of Tenofovir Disoproxil Fumarate Based Regimen as Compared to Zidovudine Based Regimens: A Systematic Review and Meta-Analysis.

AIDS Res Treat 2017 30;2017:5792925. Epub 2017 May 30.

College of Health Sciences, Mizan-Tepi University, Mizan Teferi, Ethiopia.

Background: Although tenofovir (TDF)/emtricitabine (FTC)/efavirenz (EFV) and zidovudine (ZDV)/lamivudine (3TC)/efavirenz (EFV) are used as preferred first line regimen, their head-to-head comparison in terms of their efficacy and tolerability was limited. This review aimed to synthesize the best available evidence on the comparative efficacy and tolerability of the two regimens.

Methods: Seven sites and databases in addition to Google search until August 20, 2016, were searched. Read More

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http://dx.doi.org/10.1155/2017/5792925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468550PMC
May 2017
5 Reads
4 Citations

Factors Affecting Utilization of Voluntary HIV Counseling and Testing Services among Teachers in Awi Zone, Northwest Ethiopia.

AIDS Res Treat 2017 23;2017:9034282. Epub 2017 Apr 23.

Public Health Emergency Management, Awi Zone Health Department, Injibara, Ethiopia.

HIV/AIDS affects the basic educational sector which is the most productive segment of the population and vital to the creation of human capital. The loss of skilled and experienced teachers due to the problem is increasingly compromising the provision of quality education in most African countries. The study was proposed to determine the magnitude of VCT utilization and assess contributing factors that affect VCT service utilization among secondary school teachers in Awi Zone. Read More

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http://dx.doi.org/10.1155/2017/9034282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420412PMC
April 2017
18 Reads

Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda.

AIDS Res Treat 2017 2;2017:3527563. Epub 2017 Apr 2.

Infectious Diseases Institute, Makerere University, Mulago Hospital, Kampala, Uganda.

. We aim to describe the time of entry into care and factors associated with being lost to program (LTP) in pregnant women on Option B Plus in an integrated HIV and antenatal care (ANC) clinic in Uganda. . Read More

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http://dx.doi.org/10.1155/2017/3527563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392405PMC
April 2017
19 Reads

A Critical Review of the Evidence Concerning the HIV Latency Reversing Effect of Disulfiram, the Possible Explanations for Its Inability to Reduce the Size of the Latent Reservoir In Vivo, and the Caveats Associated with Its Use in Practice.

AIDS Res Treat 2017 30;2017:8239428. Epub 2017 Mar 30.

Brasenose College, University of Oxford, Oxford, UK.

Combination antiretroviral therapy (cART) effectively suppresses the replication of human immunodeficiency virus type 1 (HIV-1), improves immune function, and decreases the morbidity of acquired immune deficiency syndrome (AIDS). However, it is unable to eradicate the virus because it does not eliminate latently infected cells. The latent reservoir poses the major barrier to an HIV-1 cure. Read More

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http://dx.doi.org/10.1155/2017/8239428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390639PMC
March 2017
9 Reads

Male Partners Involvement in Prevention of Mother-to-Child Transmission of HIV Services in Southern Central Ethiopia: In Case of Lemo District, Hadiya Zone.

AIDS Res Treat 2017 15;2017:8617540. Epub 2017 Mar 15.

Public Health Department, College of Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia.

Male partners' involvement is a vital issue to prevent human immunodeficiency virus (HIV) transmission from mother to child; because it is much expectable that women were more vulnerable and high risk group of population portion. Therefore, to save lives of mothers and their newborn from acquiring HIV, male partners should do their maximum endeavor regardless of any determinant factors as our results revealed its status in our study context and elsewhere at past time too. Read More

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http://dx.doi.org/10.1155/2017/8617540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376926PMC
March 2017
5 Reads

Antiretroviral Treatment Adherence: Knowledge and Experiences among Adolescents and Young Adults in Soweto, South Africa.

AIDS Res Treat 2017 20;2017:5192516. Epub 2017 Mar 20.

Perinatal HIV Research Unit, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Gauteng 1864, South Africa.

Human immunodeficiency virus (HIV) management of adolescents and young adults (AYAs) is particularly pertinent to sub-Saharan Africa, where the pediatric HIV burden is marked. Antiretroviral treatment (ART) adherence is a major challenge for AYAs. This qualitative study explored knowledge and experiences of adherence amongst AYAs attending treatment at the Perinatal HIV Research Unit (PHRU), Soweto, South Africa. Read More

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http://dx.doi.org/10.1155/2017/5192516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376918PMC
March 2017
4 Reads

Patient Experiences of Decentralized HIV Treatment and Care in Plateau State, North Central Nigeria: A Qualitative Study.

AIDS Res Treat 2017 26;2017:2838059. Epub 2017 Feb 26.

Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA; Department of Medicine, Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA.

Decentralization of care and treatment for HIV infection in Africa makes services available in local health facilities. Decentralization has been associated with improved retention and comparable or superior treatment outcomes, but patient experiences are not well understood. We conducted a qualitative study of patient experiences in decentralized HIV care in Plateau State, north central Nigeria. Read More

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http://dx.doi.org/10.1155/2017/2838059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346378PMC
February 2017
13 Reads

Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa.

AIDS Res Treat 2017 31;2017:5456219. Epub 2017 Jan 31.

HIV/AIDS & Global Health Research Programme, University of Venda, Thohoyandou, South Africa.

Optimal adherence to combination antiretroviral therapy (cART) is critical to maintain virologic suppression, thereby ensuring the global success of HIV treatment. We evaluated adherence to cART using pharmacy refill records and determined the adherence threshold resulting in >90% virologic suppression in a community run treatment site in South Africa. Additionally, we analysed factors associated with adherence using univariable and multivariable logistic regression models. Read More

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http://dx.doi.org/10.1155/2017/5456219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306970PMC
January 2017
9 Reads

Cluster-Randomized Controlled Study of SMS Text Messages for Prevention of Mother-to-Child Transmission of HIV in Rural Kenya.

AIDS Res Treat 2016 8;2016:1289328. Epub 2016 Dec 8.

Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.

. Antiretroviral medications are key for prevention of mother-to-child transmission (PMTCT) of HIV, and transmission mitigation is affected by service delivery, adherence, and retention. . Read More

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http://dx.doi.org/10.1155/2016/1289328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178353PMC
December 2016
1 Read

Analytical Performances of Human Immunodeficiency Virus Type 1 RNA-Based Amplix® Real-Time PCR Platform for HIV-1 RNA Quantification.

AIDS Res Treat 2016 5;2016:7954810. Epub 2016 Dec 5.

Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France; Université Paris Descartes, Paris Sorbonne Cité, Paris, France.

. We evaluated the performances of Amplix real-time PCR platform developed by Biosynex (Strasbourg, France), combining automated station extraction (Amplix station 16 Dx) and real-time PCR (Amplix NG), for quantifying plasma HIV-1 RNA by lyophilized HIV-1 RNA-based Amplix reagents targeting and , using samples from HIV-1-infected adults from Central African Republic. . Read More

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http://dx.doi.org/10.1155/2016/7954810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165142PMC
December 2016
48 Reads

Costing of Paediatric Treatment alongside Clinical Trials under Low Resource Constraint Environments: Cotrimoxazole and Antiretroviral Medications in Children Living with HIV/AIDS.

Authors:
Bona M Chitah

AIDS Res Treat 2016 29;2016:9456906. Epub 2016 Nov 29.

Department of Economics, University of Zambia, Lusaka, Zambia.

. Costing evidence is essential for policy makers for priority setting and resource allocation. It is in this context that the clinical trials of ARVs and cotrimoxazole provided a costing component to provide evidence for budgeting and resource needs alongside the clinical efficacy studies. Read More

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https://www.hindawi.com/journals/art/2016/9456906/
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http://dx.doi.org/10.1155/2016/9456906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153543PMC
November 2016
3 Reads

Factors Associated with PMTCT Cascade Completion in Four African Countries.

AIDS Res Treat 2016 31;2016:2403936. Epub 2016 Oct 31.

University of Alabama at Birmingham, Birmingham, AL, USA.

Many countries are working to reduce or eliminate mother-to-child transmission (MTCT) of HIV. Prevention efforts have been conceptualized as steps in a cascade but cascade completion rates during and after pregnancy are low. A cross-sectional survey was performed across 26 communities in Cameroon, Cote d'Ivoire, South Africa, and Zambia. Read More

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http://dx.doi.org/10.1155/2016/2403936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107823PMC
October 2016
11 Reads

Insights into Adherence among a Cohort of Adolescents Aged 12-20 Years in South Africa: Reported Barriers to Antiretroviral Treatment.

AIDS Res Treat 2016 27;2016:4161738. Epub 2016 Oct 27.

Empilweni Services and Research Unit, Department of Paediatrics and Child Health, University of the Witwatersrand, Rahima Moosa Mother and Child Hospital, Johannesburg, South Africa.

Adolescents experience disproportionately high rates of poor ART outcomes compared to adults despite prolonged use of antiretroviral therapy in Southern African treatment programs, presenting a significant challenge to national attempts to meet the UNAIDS 90-90-90 targets for 2020. This cohort study among adolescents aged 12-20 years accessing ART care at two urban public-sector clinics in Johannesburg between September and November 2013 aimed to identify factors potentially associated with poor attendance at clinic visits. Patients were followed up through routine medical records to identify missed visits (failing to attend clinic within 30 days of scheduled visit date) up to 2 years after enrolment. Read More

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http://dx.doi.org/10.1155/2016/4161738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102702PMC
October 2016
3 Reads

Parents Support Implementation of HIV Testing and Counseling at School: Cross-Sectional Study with Parents of Adolescent Attending High School in Gauteng and North West Provinces, South Africa.

AIDS Res Treat 2016 11;2016:4842814. Epub 2016 Oct 11.

School of Public Health, Department of Biostatistics, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

. A formative assessment of the implementation of HIV testing and counseling (HTC) at school showed high acceptability and willingness to test among learners. However, the success of the proposed HTC depends on the support and acceptability of key stakeholders, including the parents. Read More

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http://dx.doi.org/10.1155/2016/4842814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078638PMC
October 2016
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Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals.

AIDS Res Treat 2016 29;2016:2587094. Epub 2016 Sep 29.

Division of Infectious Diseases, Center for Global Health, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 900, Chicago, IL, USA.

Neurological complications associated with the human immunodeficiency virus (HIV) are a matter of great concern. While antiretroviral (ARV) drugs are the cornerstone of HIV treatment and typically produce neurological benefit, some ARV drugs have limited CNS penetration while others have been associated with neurotoxicity. CNS penetration is a function of several factors including sieving role of blood-brain and blood-CSF barriers and activity of innate drug transporters. Read More

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http://dx.doi.org/10.1155/2016/2587094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061948PMC
September 2016
10 Reads

Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection.

AIDS Res Treat 2016 6;2016:5120831. Epub 2016 Sep 6.

Hospital del Mar, Infectious Diseases, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.

Hypovitaminosis D and secondary hyperparathyroidism are frequent among HIV-infected patients. As there are no data about the best supplementation therapy both in treatment and in maintenance, we conducted an observational study of 300 HIV-infected patients for whom vitamin D and parathormone (PTH) had been measured in order to validate a protocol of vitamin D supplementation in patients with HIV-infection. Patients with vitamin D deficiency (defined as 25(OH)D < 10 ng/mL), insufficiency (defined as 25(OH)D < 20 ng/mL), or hyperparathyroidism (PTH > 65 pg/mL) were supplemented with cholecalciferol 16. Read More

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http://dx.doi.org/10.1155/2016/5120831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028798PMC
September 2016
6 Reads