269,783 results match your criteria AIDS education and prevention : official publication of the International Society for AIDS Education[Journal]


A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Int J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.015DOI Listing

A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
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http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
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Prevalence, intensity and associated risk factors of soil transmitted helminth infections: A comparison between Negritos (indigenous) in inland jungle and those in resettlement at town peripheries.

PLoS Negl Trop Dis 2019 Apr 22;13(4):e0007331. Epub 2019 Apr 22.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: Formerly known as the Malaysian hunter gatherers, the Negrito Orang Asli (OA) were heavily dependent on the forest for sustenance and early studies indicated high prevalence of intestinal parasitism. Initiation of a redevelopment program in the 1970s aimed to demarginalize the OA was expected to reduce soil transmitted helminth (STH) infections. Gradually, the OA were relocated to new resettlement areas at the peripheries. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007331DOI Listing

Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs utilizing therapeutic drug monitoring data in children living with HIV.

Ther Drug Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud university medical centre, Nijmegen, The Netherlands.

Introduction: This review summarises the current dosing recommendations for antiretroviral drugs (ARVs) in the international pediatric guidelines of the World Health Organisation (WHO), US Department of Health and Human Services (DHHS), and Paediatric European Network for Treatment of AIDS (PENTA) and evaluates the research that informed these approaches. We further explore the role of data generated through therapeutic drug monitoring (TDM) in optimizing the dosing of ARVs in children.

Methods: A PubMed search was conducted for literature on ARV dosing published in English. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000637DOI Listing

Damage control orthopedics applied in an 8-year-old child with life-threatening multiple injuries: A CARE-compliant case report.

Medicine (Baltimore) 2019 Apr;98(16):e15294

University Children's Hospital Basel (UKBB), Department of Pediatric Surgery, 4056 Basel.

Rationale: Damage control is a staged surgical approach to manage polytraumatized patients. The damage control approach comprises three steps. First, bleeding is controlled and fractures are stabilized temporarily; second, vital parameters are stabilized and the child is rewarmed in the intensive care unit; and third, the child is reoperated for definitive repair of injuries. Read More

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http://Insights.ovid.com/crossref?an=00005792-201904190-0005
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http://dx.doi.org/10.1097/MD.0000000000015294DOI Listing
April 2019
2 Reads

The role of quantitative sensory testing in the prediction of chronic pain.

Pain 2019 May;160 Suppl 1:S66-S69

Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany.

Quantitative sensory testing (QST) is a formal variant of a time-honoured clinical examination technique in neurology, the sensory examination. Prototypical QST profiles have been found in human surrogate models of peripheral sensitization, central sensitization, and deafferentation. Probabilistic sorting of individual patients to any combination of these profiles has been developed, and there is emerging evidence for the predictive value of such sensory profiles for treatment efficacy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001544DOI Listing

Serological Markers for Syphilis Among Persons Presenting with Syndromes Associated with Sexually Transmitted Infections Results from the Zimbabwe STI Etiology Study.

Sex Transm Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington School of Medicine, Seattle, WA, USA.

Background: Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001006DOI Listing

PrEP-RN: Clinical Considerations and Protocols for Nurse-Led PrEP.

J Assoc Nurses AIDS Care 2019 Apr 9. Epub 2019 Apr 9.

HIV pre-exposure prophylaxis (PrEP) is an increasingly important part of the HIV prevention armamentarium. Issues with PrEP, however, include access. We propose that one way to surmount this issue would be to have nurses provide PrEP. Read More

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http://dx.doi.org/10.1097/JNC.0000000000000075DOI Listing

Altered neuropsychological performance and reduced brain volumetrics in people living with HIV on integrase strand transfer inhibitors.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Washington University in St Louis, St Louis, USA.

Objectives: Neuropsychiatric symptoms have been reported in people living with HIV (PLWH) on integrase strand transfer inhibitors (INSTIs) in post marketing analysis. Limited data exists regarding brain integrity (function and structure) in PLWH prescribed INSTIs compared to other HIV treatment regimens.

Design: A cross-sectional analysis of PLWH on combined antiretroviral therapy (cART) aged >18 years at a single institution. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002236DOI Listing

Traditional healers, hiv outcomes, and mortality among people living with hiv in senegal, west africa.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Washington, Seattle, WA, USA.

Objectives: The goals of this study were to determine the frequency of traditional healer (TH) use among PLHIV in Senegal, to identify predictors of TH use, and to determine if TH use is associated with HIV outcomes.

Design: Prospective longitudinal study METHODS:: Subjects were enrolled from April 2017-April 2018 in Dakar and Ziguinchor, Senegal. Interviews, clinical evaluations, laboratory analyses, and chart review were conducted. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002232DOI Listing

Clinical significance of elevated liver transaminases in HIV-infected patients.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

McGill University Health Center, Montreal, Quebec, Canada.

: Elevation of liver transaminases is common in patients infected with the Human Immunodeficiency Virus (HIV). Although this is usually an incidental finding during regular work-up, HIV-infected patients with transaminases elevations require additional visits for laboratory studies and clinical assessments, and often undergo interruptions and changes in antiretroviral therapy (ART). Alanine aminotransferase (ALT) is present primarily in the liver, thus being a surrogate marker of hepatocellular injury. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002233DOI Listing
April 2019
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Simplifying switch to second line ART: Predicted effect of defining failure of first-line efavirenz-based regimens in sub-Saharan Africa by a single viral load > 1000 copies/ml.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

Institute for Global Health, UCL, London, UK.

Background: Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan Africa never initiate second-line antiretroviral treatment (ART) or do so after significant delay. For people on ART with a viral load (VL) > 1000 copies/ml, the World Health Organization (WHO) recommends a second VL measurement 3 months after the first VL and enhanced adherence support. Switch to a second-line regimen is contingent upon a persistently elevated VL > 1000 copies/ml. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002234DOI Listing

Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

MRC Clinical Trials Unit at UCL, London, UK.

Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrition in HIV-infected children.

Design: Cross-sectional laboratory sub-study in 613 HIV-infected children initiating ART in Uganda and Zimbabwe. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002231DOI Listing

A History of Innovations in the Diagnosis and Treatment of Oral and Head and Neck Cancer.

J Dent Res 2019 May;98(5):489-497

4 Department of Pathology, University of Chicago, Chicago, IL, USA.

Historical records as far back as 3000 BCE show that oral and head and neck cancer was a disease process well known to Egyptian physicians. Luminaries such as Hippocrates, Galen, Pott, and Virchow were instrumental in shaping our understanding of the etiology and pathogenesis of cancer. During the 20th century, evidence-based medicine catalyzed the development of rigorous science-based diagnostic and treatment protocols. Read More

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http://dx.doi.org/10.1177/0022034519833645DOI Listing
May 2019
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A systematic narrative synthesis of acute amplification-induced improvements in cognitive ability in hearing-impaired adults.

Int J Audiol 2019 Apr 22:1-9. Epub 2019 Apr 22.

b Manchester Centre for Audiology and Deafness , School of Health Sciences, University of Manchester , Manchester , UK.

Objective: This systematic review investigated if hearing aid use was associated with acute improvements in cognitive function in hearing-impaired adults.

Design: The review question and inclusion/exclusion criteria were designed using the Population, Intervention, Control, Outcomes, and Study design (PICOS) mnemonic. The review was pre-registered in the International Prospective Register of Systematic Review (PROSPERO) and performed in accordance with the statement on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Read More

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http://dx.doi.org/10.1080/14992027.2019.1594414DOI Listing
April 2019
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First year post-stroke healthcare costs and fall-status among those discharged to the community.

Eur Stroke J 2018 Sep 15;3(3):254-262. Epub 2018 Mar 15.

School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland.

Introduction: Falls are common post-stroke events but their relationship with healthcare costs is unclear. The aim of this study was to examine the relationship between healthcare costs in the first year after stroke and falls among survivors discharged to the community.

Patients And Methods: Survivors of acute stroke with planned home discharges from five large hospitals in Ireland were recruited. Read More

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http://dx.doi.org/10.1177/2396987318764954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453204PMC
September 2018
1 Read

Consistent Condom Use and Associated Factors among HIV-Positive Clients on Antiretroviral Therapy in North West Ethiopian Health Center, 2016 GC.

AIDS Res Treat 2019 17;2019:7134908. Epub 2019 Mar 17.

Department of Public Health, Hawassa Health Science College, Hawassa, Ethiopia.

Background: The burden of Human Immune Deficiency Virus or Acquired Immune Deficiency Syndrome is high in sub-Saharan countries including Ethiopia which have over two-thirds of the global HIV burden. Many would argue that consistent condom use is not most effective method for HIV prevention. Condoms offer protection against unwanted pregnancy and some sexually transmitted infections including Human Immune Deficiency Virus, when used correctly and consistently. Read More

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http://dx.doi.org/10.1155/2019/7134908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441518PMC

of the femoral bone.

J Res Med Sci 2019 25;24:19. Epub 2019 Mar 25.

Department of Pathology, Lautech Teaching Hospital, Ogbomosho, Nigeria.

Histoplasmosis due to is an emerging AIDS-defining opportunistic infection in HIV positive seen predominantly on the African continent between the Tropics of Cancer and Capricorn. is an invasive fungal organism with tropism for lymph nodes, skin and bones. The infection occurs more in patients with a CD4 count <50/mm and is usually dissemnnated Histoplasmosis due to is an emerging AIDS-defining opportunistic infection in HIV positive seen predominantly on the African continent between the Tropics of Cancer and Capricorn. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_97_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450135PMC

HIVR4P 2018: From Research to Impact.

AIDS Res Hum Retroviruses 2019 Apr 22. Epub 2019 Apr 22.

International AIDS Society, 503988, Geneva, Switzerland ;

The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing HIV prevention research, responding to a growing consensus that effective and durable prevention will require a combination of approaches as well as unprecedented collaboration among scientists, practitioners and community workers from different fields and geographic areas. The conference theme in 2018, "From Research to Impact", acknowledged an increasing focus on translation of promising research findings into practical, accessible and affordable HIV prevention options for those who need them worldwide. HIVR4P 2018 was held in Madrid, Spain, on 21-25 October, with over 1,400 participants from 52 countries around the globe, representing all aspects of HIV prevention research and implementation. Read More

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http://dx.doi.org/10.1089/AID.2019.0074DOI Listing

Adverse effects of chronic treatment with the Main subclasses of highly active antiretroviral therapy: a systematic review.

HIV Med 2019 Apr 22. Epub 2019 Apr 22.

Adipose Tissue Research Group, Department of Physiological Sciences, State University of Maringá, Maringá, Brazil.

Objectives: The aim of the review was to elucidate the adverse effects of chronic treatment with the main subclasses of highly active antiretroviral therapy (HAART).

Methods: A systematic review was carried out using the methods recommended in the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). Searches of articles in MEDLINE, SCIELO, Web of Science and LILACS were conducted from January to October 2018 based on the following descriptors and keywords: 'HIV' [AND]; 'AIDS' [OR]; 'HAART' [AND]; 'Highly Active Antiretroviral Therapy' [OR]; 'Adverse Effects' [AND]. Read More

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http://dx.doi.org/10.1111/hiv.12733DOI Listing

The characteristics of internet-based venue sex-seeking and mobility among money boys in Tianjin, China.

HIV Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Epidemiology and Health Statistics, Tianjin Medical University, Tianjin, China.

Objectives: Internet-based venue sex-seeking is prevalent among money boys (MBs), as is a high degree of mobility, which is crucial for HIV transmission in key populations with high risks of HIV infection. However, correlation studies in MBs are scarce because of the secretive nature of this hard-to-reach subpopulation. We conducted this project to explore the characteristics of MBs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hiv.12746
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http://dx.doi.org/10.1111/hiv.12746DOI Listing
April 2019
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The Role of FDG-PET in Patients with Epilepsy Related to Periventricular Nodular Heterotopias: Diagnostic Features and Long-Term Outcome.

J Neuroimaging 2019 Apr 22. Epub 2019 Apr 22.

Clinic of Radiology & Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Background And Purpose: Periventricular nodular heterotopias (PNHs) are frequently associated with drug-resistant epilepsy (DRE). Although magnetic resonance imaging (MRI) can define the morphological features of PNHs, still there is a need to assess their metabolic activity in order to provide useful information on epileptogenicity and long-term outcome. To that end, we investigated the ability of F-FDG PET to identify seizure onset zone in order to assess the metabolic activity of the ectopic neurons and to provide prognostic information on the postsurgical outcome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12620
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http://dx.doi.org/10.1111/jon.12620DOI Listing
April 2019
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Immediate improvement of speech-in-noise perception through multisensory stimulation via an auditory to tactile sensory substitution.

Restor Neurol Neurosci 2019 ;37(2):155-166

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem, Israel.

Background: Hearing loss is becoming a real social and health problem. Its prevalence in the elderly is an epidemic. The risk of developing hearing loss is also growing among younger people. Read More

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http://dx.doi.org/10.3233/RNN-190898DOI Listing
January 2019

The Global Impact of HIV on Sexual and Gender Minority Older Adults: Challenges, Progress, and Future Directions.

Int J Aging Hum Dev 2019 Apr 22:91415019843456. Epub 2019 Apr 22.

3 School of Social Work, University of Washington, Seattle, WA, USA.

According to Joint United Nations Programme on HIV/AIDS (UNAIDS) data, 36.9 million people are living with HIV worldwide. Older adults, those aged 50 years and older, with HIV are increasing worldwide; however, the prevalence and incidence differ substantially across regions. Read More

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http://dx.doi.org/10.1177/0091415019843456DOI Listing
April 2019
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[Homosexual behavior and related factors among married men who have sex with men in Mianyang city, Sichuan province].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):461-465

Department of AIDS/STD Control and Prevention, Pingwu County Center for Disease Control and Prevention, Pingwu 622500, China.

To understand the homosexual behavior and related factors among married MSM in Mianyang city. Between January and October in 2017, a snowball sampling method was adopted to carry out cross-sectional survey through questionnaires plus HIV testing among those MSM in Mianyang city. Logistic regression model was used to analyze homosexual behaviors and related factors among married MSM under study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.017DOI Listing

[Study on the safety and immunogenicity of simultaneous vaccination on both hepatitis E and hepatitis B vaccines].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):451-456

Beijing Chaoyang District Center for Disease Control and Prevention, Beijing 100021, China.

Safety and immunogenicity regarding simultaneous vaccination on both hepatitis E and hepatitis B vaccines were studied. A total of 600 healthy subjects aged 18-60 were recruited in Chaoyang district of Beijing city, from September 2015 to December 2016. Subjects meeting the inclusion and exclusion criteria were randomly divided into 3 groups: the simultaneous vaccination group of hepatitis E and hepatitis B, the hepatitis B vaccination group and the hepatitis E vaccination group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.015DOI Listing

[HIV prevalence and correlated factors on male clients of female sex workers in Hekou Yao autonomous county of Yunnan province, 2014-2015].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):440-445

School of Public Health, Southeast University, Nanjing 210009, China.

To assess the prevalence and related factors of HIV infection among male clients of the female sex workers in Hekou Yao autonomous county of Honghe Hani Yi autonomous prefecture (Hekou county) in Yunnan province in China, 2014-2015. Serial cross-sectional survey was conducted during June 2014 to November 2015. Convenience sampling methods were used to recruit the male clients for this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.013DOI Listing
April 2019
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-containing Antiretroviral Therapy.

Clin Pharmacol Ther 2019 Apr 21. Epub 2019 Apr 21.

Department of Internal Medicine, Meharry Medical College School of Medicine, Nashville, TN, USA.

The human immunodeficiency virus (HIV) type-1 non-nucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat HIV-1 infection. Efavirenz is predominantly metabolized into inactive metabolites by CYP2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing based on CYP2B6 genotypes. Read More

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http://dx.doi.org/10.1002/cpt.1477DOI Listing

The Effectiveness of Social Marketing Interventions to Improve HIV Testing Among Gay, Bisexual and Other Men Who Have Sex with Men: A Systematic Review.

AIDS Behav 2019 Apr 20. Epub 2019 Apr 20.

MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, 200 Renfield Street, Glasgow, Scotland, G2 3AX, UK.

HIV testing is central to biomedical HIV prevention, but testing among men who have sex with men remains suboptimal. We evaluated effectiveness of mass media and communication interventions to increase HIV testing and explored patterns between study type, internal validity and intervention effectiveness for the first time. Five databases were searched for articles published between 2009 and 2016 using standard MeSH terms. Read More

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http://dx.doi.org/10.1007/s10461-019-02507-7DOI Listing

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

BMJ Open 2019 Apr 20;9(4):e028444. Epub 2019 Apr 20.

The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. HIV persists in long-lived CD4+ T cells, which form the major viral reservoir. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028444DOI Listing

Locked-in syndrome in Sweden, an explorative study of persons who underwent rehabilitation: a cohort study.

BMJ Open 2019 Apr 20;9(4):e023185. Epub 2019 Apr 20.

Institution of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Objective: Locked-in syndrome (LiS) is a rare condition, characterised by a complete paresis except for vertical eye movements and blinking with cognitive functions intact, commonly caused by ischaemia in the ventral pons. Previous studies have indicated that persons with LiS can live on for many years and have a good quality of life (QoL). To our knowledge, LiS has never been studied in Sweden. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023185DOI Listing

Mind the gap: observation windows to define periods of event ascertainment as a quality control method for longitudinal electronic health record data.

Ann Epidemiol 2019 Mar 4. Epub 2019 Mar 4.

Johns Hopkins University, Baltimore, MD.

Purpose: Use of electronic health records (EHRs) in health research may lead to the false assumption of complete event ascertainment. We estimated "observation windows" (OWs), defined as periods within which the assumption of complete ascertainment of events is more likely to hold, as a quality control approach to reducing the likelihood of this false assumption. We demonstrated the impact of OWs on estimating the rates of type II diabetes mellitus (diabetes) from HIV clinical cohorts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10472797183054
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http://dx.doi.org/10.1016/j.annepidem.2019.01.015DOI Listing
March 2019
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Effect of Withania somnifer on CD38 expression on CD8+ T lymphocytes among patients of HIV infection.

Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

National HIV/AIDS Reference Laboratory, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

CD38 on CD8 + T cells is considered a reliable marker of HIV disease progression. Withania somnifer, a traditional ayurvedic medicine, has Th1 immunomodulatory properties. PBMCs from 38 HIV patients were exposed to Withania somnifer root extract at standardized concentration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616193009
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http://dx.doi.org/10.1016/j.clim.2019.04.003DOI Listing
April 2019
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Modeling the Effect of Tat Inhibitors on HIV Latency.

J Theor Biol 2019 Apr 17. Epub 2019 Apr 17.

Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Unidad Monterrey, Via del Conocimiento 201, Parque PIIT, Apodaca CP 66600 NL, México. Electronic address:

Even in the presence of a successful combination therapy stalling the progress of AIDS, developing a cure for this disease is still an open question. One of the major steps towards a cure would be to be able to eradicate latent HIV reservoirs present in patients. During the last decade, multiple findings point to the dominant role of the viral protein Tat in the establishment of latency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225193193015
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http://dx.doi.org/10.1016/j.jtbi.2019.04.018DOI Listing
April 2019
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The contribution of KSHV to mortality in hospitalized HIV-infected patients being investigated for tuberculosis in South Africa.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Division of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, University of Cape Town, South Africa.

Background: Despite increasing numbers of human immunodeficiency virus (HIV)-infected South Africans receiving antiretroviral therapy (ART), tuberculosis remains the leading cause of mortality. Approximately 25% of patients treated for tuberculosis have microbiologically unconfirmed diagnoses. We assessed whether elevated Kaposi's sarcoma-associated Herpes Virus (KSHV) viral load (VL) contributes to mortality in hospitalized HIV-infected patients investigated for tuberculosis. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz180DOI Listing
April 2019
1 Read

Behavioral and Cardiovascular Effects of a Behavioral Weight Loss Program for People Living with HIV.

AIDS Behav 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI, USA.

We recently reported that a 12-week internet weight loss program produced greater weight losses than education control in overweight/obese people living with HIV (PLWH) (4.4 kg vs 1.0 kg; p < 0. Read More

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http://dx.doi.org/10.1007/s10461-019-02503-xDOI Listing

Cross-Sectional Study of Sexual Behavior, Alcohol Use, and Mental Health Conditions Associated With Sexually Transmitted Infections Among Deploying Shipboard US Military Personnel.

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Defense HIV/AIDS Prevention Program, Defense Health Agency, 140 Sylvester Rd Bldg 306, San Diego, CA 92106.

Introduction: Limited comprehensive data exist on risk behavior associated with sexually transmitted infections (STI) among ship-assigned US military personnel during the predeployment time period (PDT). This study examined whether sexual risk behaviors, alcohol use, involuntary drug consumption (IDC), posttraumatic stress disorder (PTSD), and depression during the 12 months prior to deployment were associated with provider-diagnosed STIs in this population.

Materials And Methods: Using cross-sectional data collected during 2012-2014 among sexually active personnel, multivariable regression assessed factors associated with STIs among all men (n = 1,831). Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz070DOI Listing
April 2019
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An exploration of the disease burden due to Cryptosporidium in consumed surface water for sub-Saharan Africa.

Int J Hyg Environ Health 2019 Apr 16. Epub 2019 Apr 16.

Environmental Systems Analysis Group, Wageningen University, P.O. Box 47, 6700, AA, Wageningen, the Netherlands.

The protozoan pathogen Cryptosporidium is an important cause of diarrhoeal disease, but in many contexts its burden remains uncertain. The Global Waterborne Pathogen model for Cryptosporidium (GloWPa-Crypto) predicts oocyst concentrations in surface water at 0.5 by 0. Read More

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http://dx.doi.org/10.1016/j.ijheh.2019.04.004DOI Listing

Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, 130021, China; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:

The lentiviral accessory protein Vpx enhances viral replication in macrophages, dendritic cells and resting CD4 T cells by utilizing the host CRL4-DCAF1 E3 ligase to trigger the degradation of the intrinsic antiviral factor SAMHD1. Distinct from the species-specific recognition of either the N or C-terminus of SAMHD1 by Vpx proteins of different HIV-2 and SIV lineages, Vpx recruits SAMHD1 onto the same CRL4-DCAF1 complex. However, the determinants in DCAF1 that are required for Vpx-mediated SAMHD1 degradation have not been well characterized. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.085DOI Listing

Document-level attention-based BiLSTM-CRF incorporating disease dictionary for disease named entity recognition.

Comput Biol Med 2019 Apr 7;108:122-132. Epub 2019 Apr 7.

Department of Computer Science, Guangdong University of Technology, Guangzhou, China. Electronic address:

Background: Disease named entity recognition (NER) plays an important role in biomedical research. There are a significant number of challenging issues to be addressed; among these, the identification of rare diseases and complex disease names and the problem of tagging inconsistency (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193011
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http://dx.doi.org/10.1016/j.compbiomed.2019.04.002DOI Listing
April 2019
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Effects of directional sound processing and listener's motivation on EEG responses to continuous noisy speech: Do normal-hearing and aided hearing-impaired listeners differ?

Hear Res 2019 Apr 11;377:260-270. Epub 2019 Apr 11.

Institute of Clinical Research, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. Electronic address:

Objective: It has been suggested that the next major advancement in hearing aid (HA) technology needs to include cognitive feedback from the user to control HA functionality. In order to enable automatic brainwave-steered HA adjustments, attentional processes underlying speech-in-noise perception in aided hearing-impaired individuals need to be better understood. Here, we addressed the influence of two important factors for the listening performance of HA users - hearing aid processing and motivation - by analysing ongoing neural responses during long-term listening to continuous noisy speech. Read More

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http://dx.doi.org/10.1016/j.heares.2019.04.005DOI Listing

Pilot Study of a Patient Decision Aid for Valve Choices in Surgical Aortic Valve Replacement.

Ann Thorac Surg 2019 Apr 16. Epub 2019 Apr 16.

Division of Cardiac Surgery, Corrigan Minehan Heart Center, Massachusetts General Hospital. Electronic address:

Background: Objective superiority of tissue versus mechanical prostheses in surgical aortic valve replacement (SAVR) remains controversial, placing a greater emphasis on patients to consider personal lifestyle and risk preferences including the burden of lifelong anticoagulation and the possible need for reoperation. A shared-decision making tool may therefore be of value in making this important choice.

Methods: A Patient Decision Aid (PtDA) was developed using the International Patient Decision Aids Standards and used in a prospective pilot study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193055
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.048DOI Listing
April 2019
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Novel Method for Rapid Detection of Spatiotemporal HIV Clusters Potentially Warranting Intervention.

Emerg Infect Dis 2019 May;25(5):988-991

Rapid detection of increases in HIV transmission enables targeted outbreak response efforts to reduce the number of new infections. We analyzed US HIV surveillance data and identified spatiotemporal clusters of diagnoses. This systematic method can help target timely investigations and preventive interventions for maximum public health benefit. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-0776_article.htm
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http://dx.doi.org/10.3201/eid2505.180776DOI Listing
May 2019
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Fighter pilots' teamwork: a descriptive study.

Ergonomics 2019 Apr 19:1-11. Epub 2019 Apr 19.

b University of Skövde , Skövde , Sweden.

The execution of teamwork varies widely depending on the domain and task in question. Despite the considerable diversity of teams and their operation, researchers tend to aim for unified theories and models regardless of field. However, we argue that there is a need for translation and adaptation of the theoretical models to each specific domain. Read More

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http://dx.doi.org/10.1080/00140139.2019.1596319DOI Listing
April 2019
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Transmitted HIV-1 drug resistance in a treatment naïve cohort of recently infected individuals from Chennai, India.

AIDS Res Hum Retroviruses 2019 Apr 19. Epub 2019 Apr 19.

National Institute for Research in Tuberculosis, HIV/AIDS, Chennai, Tamil Nadu, India ;

A cross sectional study was undertaken to examine the prevalence and pattern of HIV drug resistance mutations among recently HIV-1 infected and antiretroviral therapy-naïve individuals from Chennai, South India. The HIV-1 Pol gene encompassing the Protease and Reverse Transcriptase (RT) regions were analysed from 53 ART -naïve HIV-1 infected individuals using an in-house method for identifying drug resistance mutations by genotyping. The overall prevalence of transmitted drug resistance (TDR) was found to be 11. Read More

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http://dx.doi.org/10.1089/AID.2019.0022DOI Listing

Prevalence of Cognitive Impairment and Its Predictors among HIV/AIDS Patients on Antiretroviral Therapy in Jimma University Medical Center, Southwest Ethiopia.

Psychiatry J 2019 13;2019:8306823. Epub 2019 Mar 13.

Department of Biomedical Sciences, College of Medicine and Health Science, Wolkite University, Wolkite, Ethiopia.

Background: Cognitive impairment among human immunodeficiency virus (HIV) infected patients can lead to treatment nonadherence, faster progression of the illness, disability, and bed ridden state if we fail to detect it early. However, there is scarcity of previous published studies in Ethiopia on the assessment of cognitive impairment among HIV-positive patients. Hence, this study aimed to determine the prevalence and associated factors of cognitive impairment among HIV-positive patients receiving antiretroviral therapy (ART) at Jimma University Medical Center, Ethiopia. Read More

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https://www.hindawi.com/journals/psychiatry/2019/8306823/
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http://dx.doi.org/10.1155/2019/8306823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436374PMC
March 2019
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Toward DNA-Based T-Cell Mediated Vaccines to Target HIV-1 and Hepatitis C Virus: Approaches to Elicit Localized Immunity for Protection.

Front Cell Infect Microbiol 2019 3;9:91. Epub 2019 Apr 3.

Virology Laboratory, Basil Hetzel Institute for Translational Health Research, Discipline of Surgery, University of Adelaide, Adelaide, SA, Australia.

Human immunodeficiency virus (HIV)-1 and hepatitis C virus (HCV) are major contributors to the global disease burden with many experts recognizing the requirement of an effective vaccine to bring a durable end to these viral epidemics. The most promising vaccine candidates that have advanced into pre-clinical models and the clinic to eliminate or provide protection against these chronic viruses are viral vectors [e.g. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00091
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http://dx.doi.org/10.3389/fcimb.2019.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456646PMC
April 2019
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Sleep disturbances in HIV-infected patients associated with depression and high risk of obstructive sleep apnea.

SAGE Open Med 2019 8;7:2050312119842268. Epub 2019 Apr 8.

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Objective: To evaluate sleep disturbances in a diverse, contemporary HIV-positive patient cohort and to identify demographic, clinical, and immune correlates.

Methods: A convenience sample of 176 patients from a racially and ethnically diverse HIV-positive patient cohort in an urban population. This was a cross-sectional, epidemiologic study. Read More

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http://dx.doi.org/10.1177/2050312119842268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454647PMC
April 2019
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Exploring the Decisional needs of Parents with Children with ADHD and Disruptive and Aggressive Behaviour.

J Can Acad Child Adolesc Psychiatry 2019 Apr 1;28(1):30-41. Epub 2019 Mar 1.

Department of Clinical Neurosciences, Psychiatry, Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta.

Objective: The aim of this qualitative study was to explore the decisional needs of parents of children with ADHD and disruptive and aggressive behaviour to inform the creation of a patient decision aid.

Method: A one-day meeting of researchers, community advocacy partners, and 11 parents of children (age range eight to 21) with aggressive and disruptive behaviour associated with a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder or Conduct Disorder was held. This meeting consisted of a two-hour educational session on the assessment and management of aggressive and disruptive behaviour in children and patient decision aids, followed by two concurrent focus groups to determine the decisional needs of parents. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457443PMC
April 2019
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