268,110 results match your criteria AIDS education and prevention : official publication of the International Society for AIDS Education[Journal]


Novel trajectories for identifying asthma phenotypes: a longitudinal study in Korean asthma cohort, COREA.

J Allergy Clin Immunol Pract 2019 Feb 19. Epub 2019 Feb 19.

Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability of airway inflammation.

Objective: We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.02.011DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Is sexual autonomy a protective factor for neonatal, child, and infant mortality? A multi-country analysis.

PLoS One 2019 22;14(2):e0212413. Epub 2019 Feb 22.

Tafiti Research Group, Nairobi, Kenya.

Background: Sexual autonomy empowers women to set boundaries, take control of their bodies, prevent sexually transmitted diseases and avoid unplanned pregnancy. A woman's ability to negotiate safer sex is crucial for her survival and that of her child. Sexual autonomy among East African women is vital to the elimination of the deaths of neonates, infants, and children. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212413PLOS
February 2019

Repeat HIV testing practices in the era of HIV self-testing among adults in KwaZulu-Natal, South Africa.

PLoS One 2019 22;14(2):e0212343. Epub 2019 Feb 22.

School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

Repeat HIV testing is important in high HIV burden communities to enable sustainability of prevention initiatives; however, an understanding of repeat testing practices is limited. Additional HIV testing approaches may be required to increase testing. HIV self-testing is an additional testing approach, but knowledge on its potential for repeat testing is limited. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212343PLOS
February 2019

Shedding light on a HIV blind spot: Factors associated with men's HIV testing in five African countries.

Glob Public Health 2019 Feb 22:1-11. Epub 2019 Feb 22.

b Office of HIV/AIDS , United States Agency for International Development , Washington , DC , USA.

Men's relatively low rates of HIV testing has been termed the 'HIV blind spot' and recently declared by UNAIDS as a top priority. This study uses data from five nationally representative Demographic and Health Surveys in Kenya, Malawi, Mozambique, Zambia, and Zimbabwe to explore factors associated with men's lifetime HIV testing. Between 29. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17441692.2019.1583266DOI Listing
February 2019

Does Denosumab Change the Giant Cell Tumor Treatment Strategy? Lessons Learned From Early Experience.

Clin Orthop Relat Res 2018 Sep;476(9):1773-1782

M. G. Agarwal, M. K. Gundavda, R. Reddy, Orthopedic Oncology, PD Hinduja Hospital and Medical Research Center, Mumbai, India R. Gupta, Orthopedic Oncology, Fortis Hospital Mohali, India.

Background: Although giant cell tumors (GCTs) are benign, their aggressiveness and tendency to recur locally challenge the orthopaedic surgeon's ability to perform joint-preserving intralesional surgery with an acceptably low risk of local recurrence. Denosumab has emerged as a possible medical treatment of GCT because it seems to halt the progression of GCT, alleviate pain, and increase perilesional bone formation, but its exact role has been questioned, and specifically its efficacy and associated complications are not well characterized.

Questions/purposes: (1) Does denosumab reduce the risk of recurrence after resection or intralesional surgery? (2) What are the complications associated with the use of denosumab?

Methods: Fifty-four patients with 30 primary and 25 recurrent tumors between November 2013 and July 2016 were treated with denosumab after a confirmed histopathologic diagnosis of GCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11999.0000000000000243DOI Listing
September 2018

Serious Choices: A Systematic Environmental Scan of Decision Aids and Their Use for Seriously Ill People Near Death.

J Hosp Med 2019 Feb 20;14:E1-E9. Epub 2019 Feb 20.

The Dartmouth Institute for Health Policy & Clinical Practice Lebanon, New Hampshire.

Seriously ill people near death face difficult decisions about life-sustaining treatments such as cardiopulmonary resuscitation and mechanical ventilation. Patient decision aids may improve alignment between patients' preferences and the care they receive, but the quantity, quality, and routine use of these tools are unknown. We conducted a systematic environmental scan to identify all decision aids for seriously ill people at high risk of death facing choices about life-sustaining treatments, assess their quality, and explore their use in clinical settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12788/jhm.3137DOI Listing
February 2019

Characterization of Four Nearly Full-Length Genomic Sequences of HIV-1 subtype G Identified in Guangdong Province, China.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

Beijing Institute of Microbiology and Epidemiology , 20 Dongda Street , Fengtai District , Beijing , Beijing, China , 100071 ;

Four cases infected by HIV-1 subtype G strain were identified in Guangdong, China. The nearly full-length genome were amplified and sequenced for phylogenetic analysis. The 4 sequences clustered together with subtype G references in the tree (bootstrap value ≥98%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2019.0025DOI Listing
February 2019

Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/07_BC) From a Married Men Who Have Sex with Men in Zhejiang, China.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

The First Affiliated Hospital, School of Medicine, Zhejiang University, Infectious Diseases Department , Hangzhou , Hangzhou, Zhejiang, China , 310000.

We report here a novel HIV-1 recombinant form detected from a married HIV-positive man infected through homosexual behavior in Zhejiang, China. The breakpoint analysis of near full-length genome (NFLG) demonstrated a complex genome organization comprised of two circulating recombinant forms, CRF01_AE and CRF07_BC, both well-known CRFs circulating in China. The parental CRF01_AE region (II) of recombinant clustered together with a previously reported cluster 4 lineage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2018.0271DOI Listing
February 2019

Polymorphisms in Toll-like receptors (TLRs) - 7 and 9 genes in Indian population with progressive and non-progressive HIV-1 infection.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

National AIDS Research Institute, 81748, Immunology & Serology , Plot No. 73, G-Block, , MIDC, Bhosari , Pune , Pune, Maharashtra, India , 411026 ;

The polymorphisms in TLR7&9 genes are shown to influence on HIV-1 infection. We studied HIV-1 infected Indian individuals for presence and association of TLR7 and 9 gene polymorphism with different disease outcomes. Genomic DNA from 65 HIV infected (35 long-term non progressors, 30 progressors) and 89 uninfected healthy donors was isolated, amplified and sequenced for the reported polymorphisms in TLR7 [Gln11Leu (A/T); rs179008] and TLR9 (1635A/G; rs352140) genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2019.0004DOI Listing
February 2019

Emerging patterns in HIV-1 gp120 variable domains in anatomical tissues in the absence of a plasma viral load.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

The AIDS and Cancer Specimen Resource , University of California, San Francisco , San Francisco, United States , 94121.

The HIV envelope protein contains five hypervariable domains (V1-V5) that are fundamental for cell entry. We contrasted modifications in the variable domains derived from a panel of 24 tissues from 7 subjects with no measurable plasma viral load (NPVL) to variable domains from 76 tissues from 15 subjects who had a detectable plasma viral load (PVL) at death. NPVL subject's V1 and V2 domains were usually highly length variable, whereas length variation in PVL sequences was more conserved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2018.0267DOI Listing
February 2019

Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Virus Form in Guizhou, China.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

Guiyang cityGuiyang, China , 550000 ;

We identified a novel CRF01_AE and 07_BC HIV-1 recombinant form in Guizhou province in southwest China. The phylogenetic analysis of the near full-length sequence reveals that it was divided into five segments by four breakpoints, and the CRF01_AE regions of the recombinant were clustered with sub-cluster 4 lineage of CRF01_AE, which mainly circulating among men who have sex with men (MSM) in china. The CRF07_BC regions of the recombinant were clustered with CRF07_BC lineage which circulating in Chinese MSM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2019.0010DOI Listing
February 2019

Mutations in LTR kB transcription factor binding sites in plasma virus among South African people living with HIV-1 (PLHIV).

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

Stellenbosch University, Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, , PO Box 19063 , Francie van Zijl Avenue , Cape Town, Western Cape Province, South Africa , 7505 ;

HIV-1 subtype C (HIV-1C) is responsible for the majority of infections in sub-Saharan Africa. We selected 63 plasma-derived samples and generated Long Terminal Repeats (LTR) amplicons from people living with HIV (PLHIV) in South Africa to identify transcription factor binding sites. NF-kB plays an important role in regulating the viral gene expression from the viral promoter and controlling viral latency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2018.0293DOI Listing
February 2019

Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Virus Among Men Who Have Sex with Men in Tianjin, China.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

Beijing, China ;

We report here a novel HIV-1 second-generation recombinant form composed of CRF01_AE and CRF07_BC isolated from an HIV-positive male subject infected among men who have sex with men (MSM) in Tianjin in north China. The phylogenetic analysis of the near full-length genome (NFLG) of TJIH0345 reveals that three regions of CRF01_AE insert into the CRF07_BC backbone with five recombinant breakpoints observed in the pol, vif, vpu and env gene regions whose genome structure is distinctly different from other circulating recombinant forms (CRFs) and unique recombinant forms (URFs) previously reported. The continued emergence of the novel recombinant strain in TianJin, China, highlights the increasing complexity of the HIV-1 epidemic among the MSM population and further molecular epidemiological investigation should be taken to track the genetic evolution of HIV-1 strains to prevent HIV transmissions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2018.0266DOI Listing
February 2019

Absence of Integrase Strand Transfer Inhibitor Associated Resistance in Antiretroviral Therapy Naïve and Experienced Individuals from Western India.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

Armed Forces Medical College, 29590, Internal Medicine, Pune, Maharashtra, India ;

Background: The Indian national AIDS control program heavily relies on low cost nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI and NNRTI). With global increase in resistance to these, alternative antiretroviral combinations need to be explored. Owing to higher potency, better efficacy and tolerability, recently WHO recommended integrase strand transfer inhibitor (INSTI) based first-line antiretroviral therapy (ART). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2018.0272DOI Listing
February 2019

Low frequency of protease inhibitor resistance mutations and insertions in HIV-1 subtype C protease inhibitor naïve sequences.

AIDS Res Hum Retroviruses 2019 Feb 22. Epub 2019 Feb 22.

National Institute for Communicable Diseases, Centre for HIV and STIs, Johannesburg, South Africa.

HIV-1 protease sequences from 2,225 protease inhibitor (PI)-naïve HIV-1 subtype C infected individuals collected over a 14 year period were analyzed for polymorphisms. Over 50% of sequences differed from an HIV-1 subtype B consensus sequence at eight of the 99 amino acids at residues 12, 15, 19, 36, 41, 69, 89 and 93 but not in the functionally important regions. The frequency of primary resistance and accessory mutations occurred in less than 1% of the sequences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2019.0012DOI Listing
February 2019

National guidelines and multilingual age-adapted patient brochures and videos as decision aids for fertility preservation of children and teenagers with cancer - A multidisciplinary effort to improve children's information and access to fertility preservation in Sweden.

Acta Obstet Gynecol Scand 2019 Feb 21. Epub 2019 Feb 21.

Institute of Clinical Sciences, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Despite several evidence-based guidelines available to promote fertility preservation (FP) for young patients and children, young patients still report FP as one of the top five unmet needs during their cancer care. Surveys have identified barriers that limit patients' access to FP, including organization-related barriers, such as lack of inter-professional cooperation, unclear referral paths for FP and the cost of the procedures. This article is protected by copyright. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aogs.13588DOI Listing
February 2019

[Decision aid for the treatment of psychotic illness: development of TReatment E-AssisT (TREAT)].

Tijdschr Psychiatr 2019 ;61(2):92-96

Background: Use of decision aids in mental health care is increasing and will also be introduced in the Dutch mental healthcare system. We describe the context of this development and discuss how decision aids could facilitate evidence-based psychiatry.
AIM: To describe the development of the decision aid TReatment E-Assist (TREAT) in the Dutch mental healthcare system that aims to optimize treatment of people with a psychotic illness. Read More

View Article

Download full-text PDF

Source
January 2019

RE: A reappraisal of sex-specific cancer survival trends among adolescents and young adults in the United States.

J Natl Cancer Inst 2019 Feb 21. Epub 2019 Feb 21.

Department of Radiation Medicine and Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon and Department of Pediatrics, University of Texas Medical School at Houston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djz019DOI Listing
February 2019

Racial Disparities in Virologic Failure and Tolerability During Firstline HIV Antiretroviral Therapy.

Open Forum Infect Dis 2019 Feb 12;6(2):ofz022. Epub 2019 Feb 12.

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Background: Racial/ethnic disparities in HIV outcomes have persisted despite effective antiretroviral therapy. In a study of initial regimens, we found viral suppression varied by race/ethnicity. In this exploratory analysis, we use clinical and socioeconomic data to assess factors associated with virologic failure and adverse events within racial/ethnic groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofz022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372057PMC
February 2019

Rectal prolapse and urinary retention: A case report of an "anal cystocele".

Case Rep Womens Health 2019 Jan 4;21:e00100. Epub 2019 Feb 4.

UT Southwestern Medical Center, Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, United States.

Background: Concomitant rectal and vaginal prolapse is diagnosed in 14-55% of patients who present for pelvic floor evaluation.Case: A patient was referred for pelvic floor evaluation in the setting of rectal prolapse and urinary retention. Preoperative magnetic resonance (MR) imaging revealed the presence of a posterior cystocele prolapsing through the full-thickness rectal prolapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.crwh.2019.e00100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370581PMC
January 2019

On the discriminatory and predictive accuracy of the RDT against the microscopy in the diagnosis of malaria among under-five children in Nigeria.

Malar J 2019 Feb 21;18(1):46. Epub 2019 Feb 21.

Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Accurate identification of malaria cases is crucial to the management of cases and the eventual success of malaria eradication agenda. This study is designed to evaluate the discriminatory and predictive accuracy of malaria rapid diagnostic tests (RDTs) in Nigeria.

Methods: The data obtained during the 2015 Nigeria Malaria Indicator Survey was used to quantify the discriminatory accuracy of the RDT against the microscopy through the analysis of its sensitivity, specificity, positive (LR+) and negative (LR-) likelihood ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12936-019-2678-1DOI Listing
February 2019

Progressive disseminated histoplasmosis with concomitant disseminated nontuberculous mycobacterial infection in a patient with AIDS from a nonendemic region (California).

BMC Pulm Med 2019 Feb 21;19(1):46. Epub 2019 Feb 21.

Department of Infectious Disease, Arrowhead Regional Medical Center, Colton, USA.

Background: Opportunistic infections, while well studied in the AIDS population, continue to have variable and surprising presentations. Here, we present a case of disseminated histoplasmosis with disseminated nontuberculous mycobacterial infection in a 50 year old man with long standing AIDS living in a non-endemic area.

Case Presentation: Patient presented with a constellation of symptoms, and imaging of the chest showed a pulmonary mass with cavitation, multiple nodules, and ground glass opacities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0808-8DOI Listing
February 2019

Narrating the Transition to Adulthood for Youth in Uganda: Leaving School, Mobility, Risky Occupations, and HIV.

Health Educ Behav 2019 Feb 21:1090198119829197. Epub 2019 Feb 21.

1 Columbia University, New York, NY, USA.

School enrollment, mobility, and occupation are each important factors to consider when examining HIV (human immunodeficiency virus) infection risk among youth in sub-Saharan Africa. Through an analysis of narrative life histories from 30 HIV-positive and 30 HIV-negative youth (aged 15-24 years), matched on gender, age, and village and purposively selected and interviewed from the Rakai Community Cohort Study, this article shows the complex connection between leaving school, mobility, and occupation with implications for HIV risk. We identified a pattern of risk factors that was present in many more HIV-positive than HIV-negative youth life stories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1090198119829197DOI Listing
February 2019

Caffeine Supplementation and Physical Performance, Muscle Damage and Perception of Fatigue in Soccer Players: A Systematic Review.

Nutrients 2019 Feb 20;11(2). Epub 2019 Feb 20.

Department of Cellular Biology, Histology and Pharmacology. Faculty of Physical Therapy, University of Valladolid. Campus de Soria, 42004 Soria, Spain.

Soccer is a complex team sport and success in this discipline depends on different factors such as physical fitness, player technique and team tactics, among others. In the last few years, several studies have described the impact of caffeine intake on soccer physical performance, but the results of these investigations have not been properly reviewed and summarized. The main objective of this review was to evaluate critically the effectiveness of a moderate dose of caffeine on soccer physical performance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11020440DOI Listing
February 2019

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

Cancers (Basel) 2019 Feb 19;11(2). Epub 2019 Feb 19.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam-781039, India.

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is considered as a potent tumor suppressor as most of its target substrates can function as potential growth promoters, including c-Myc, Notch, cyclin E, c-JUN, and KLF5. Its regulators include p53, C/EBP-δ, Numb, microRNAs, Pin 1, Hes-5, BMI1, Ebp2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11020246DOI Listing
February 2019

Target-Activated DNA Polymerase Activity for Sensitive RNase H Activity Assay.

Biotechnol J 2019 Feb 21:e1800645. Epub 2019 Feb 21.

Department of Chemical and Biomolecular Engineering (BK 21+ program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

We herein described RNase H activity assay based on the target-activated DNA polymerase activity. In the method, a detection probe composed of two functional sequences: one is the binding site for DNA polymerase and the other is the catalytic substrate for RNase H, respectively, serves as a key component. The detection probe, at its initial state, suppresses the DNA polymerase activity, but it becomes destabilized by RNase H, which specifically hydrolyzes RNA in RNA/DNA hybrid duplex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/biot.201800645DOI Listing
February 2019

Decision aids for people with Type 2 diabetes mellitus: an effectiveness rapid review and meta-analysis.

Diabet Med 2019 Feb 21. Epub 2019 Feb 21.

Clinical Research and Evidence-Based Medicine Unit, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Aims: To perform a rapid review and meta-analysis of randomized controlled trials (RCTs) evaluating patient decision aids (PtDAs) for people with Type 2 diabetes mellitus.

Methods: We searched Medline and the Cochrane Library for RCTs assessing PtDAs in people with Type 2 diabetes. PtDAs were defined as tools designed to help people engage in decision-making about healthcare options, such as making treatment choices or setting therapeutic goals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dme.13939DOI Listing
February 2019

Post Option B+ implementation programme in Nigeria: Determinants of adherence of antiretroviral therapy among pregnant women with HIV.

Int J Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Department of Nursing, School of Health Sciences, The University of Melbourne, Melbourne, Australia.

Objective: Nigeria has the highest rate of mother to child transmission of HIV (MTCT) in the world. By 2015, all Global Plan priority countries, except Nigeria, had adopted the Option B+ programme.Nigeria finally adopted Option B+ in 2016 with full implementation reported in 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.02.014DOI Listing
February 2019

[About Problems of Palliative Care].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2019 Jan;27(1):36-40

The Federal State Budget Scientific Institution "The N. A. Semashko National Research Institute of Public Health", 105064, Moscow, Russia,

The palliative care is determined as "a complex of medical interventions targeted to deliverance from pain and relief of other severe manifestations of disease, for improving quality of life of terminally ill citizens" (Art. 36 of the Federal Law of 21.11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.32687/0869-866X-2019-27-1-36-40DOI Listing
January 2019

Effect of Patient Navigation on Transitions of HIV Care After Release from Prison: A Retrospective Cohort Study.

AIDS Behav 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Antiretroviral therapy is successfully administered to people living with HIV while they are incarcerated in most US prison systems, but interruptions in treatment are common after people are released. We undertook an observational cohort study designed to examine the clinical and psychosocial factors that influence linkage to HIV care and viral suppression after release from a single state prison system. In this report we describe baseline characteristics and 6-month post-incarceration HIV care outcomes for 170 individuals in Wisconsin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10461-019-02437-4DOI Listing
February 2019

Radical antegrade modular pancreatosplenectomy for all pancreatic body and tail tumors: rationale and results.

Langenbecks Arch Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Gastrointestinal and HPB Surgery, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India.

Background: Radical antegrade modular pancreatosplenectomy (RAMPS) has been propagated as the standard of care for pancreatic cancers involving the body and tail of the pancreas. This procedure has been shown to have promising results in enhancing the microscopically negative tangential resection margins as well as the lymph node yield.

Methods: This is a retrospective analysis of prospectively maintained database on the resections performed for all pancreatic body and tail tumors at Tata Memorial Centre. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00423-019-01763-4DOI Listing
February 2019

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

PLoS Pathog 2019 Feb 21;15(2):e1007567. Epub 2019 Feb 21.

Laboratory of Viral Diseases, NIAID, Bethesda, Maryland, United States of America.

Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007567DOI Listing
February 2019

Approach to amoebic colitis: Epidemiological, clinical and diagnostic considerations in a non-endemic context (Barcelona, 2007-2017).

PLoS One 2019 21;14(2):e0212791. Epub 2019 Feb 21.

Infectious Disease Department, AIDS Research Institute-IrsiCaixa, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.

Background: Amoebic colitis is the most frequent clinical manifestation of invasive intestinal infection due to Entamoeba histolytica and a common cause of diarrhoea worldwide. Since higher transmission rates are usually related to poor health and exposure to unhygienic conditions, cases reported in Europe usually involve immigrants and international travellers. The goal of this study was to characterise both the clinical and the epidemiological features of a European population diagnosed with amoebic colitis and then to evaluate the diagnostic tools and therapeutic options applied. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212791PLOS
February 2019

Leveraging Informatics to Identify Reportable Cases: Pilot Findings on Electronic Case Reporting of Chlamydia and Gonorrhea.

J Public Health Manag Pract 2019 Feb 14. Epub 2019 Feb 14.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia (Dr Mishra); Task Force for Global Health, Public Health Informatics Institute, Decatur, Georgia (Mr Jellison and Ms Viator); and AllianceChicago, Chicago, Illinois (Messrs Hamilton and Carr and Ms Padilla).

Consensus-based technical guidance for electronic case reporting (eCR) of sexually transmitted infections was implemented within existing health information technologies to automatically detect chlamydia and gonorrhea cases based on diagnosis and laboratory observation codes and build a case report using industry standards. The process was evaluated using 12 420 ambulatory encounters among adolescents and adults 15 years and older seen at 8 Chicago-area community health centers between May 1 and June 30, 2017. We tabulated the frequency of matches between the case detection logic and patient data and compared the eCR identified cases with paper case reports. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PHH.0000000000000954DOI Listing
February 2019

The Impact of HIV Infection on TB Disparities Among US-Born Black and White Tuberculosis Patients in the United States.

J Public Health Manag Pract 2019 Feb 14. Epub 2019 Feb 14.

US Centers for Disease Control and Prevention (CDC), Atlanta, Georgia (Mss Marks and Pagaoa and Dr Katz); New Jersey Medical School at Rutgers, Newark, New Jersey (Dr Davidow); Forensic Research and Analysis, Lake Oswego, Oregon (Dr Teeter); and Houston Methodist Research Institute, Houston, Texas (Dr Graviss).

Background/objectives: US-born non-Hispanic black persons (blacks) (12% of the US population) accounted for 41% of HIV diagnoses during 2008-2014. HIV infection significantly increases TB and TB-related mortality. TB rate ratios were 6 to 7 times as high in blacks versus US-born non-Hispanic whites (whites) during 2013-2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PHH.0000000000000949DOI Listing
February 2019

The use of the Restricted Mean Survival Time as a treatment measure in HIV/AIDS clinical trial: reanalysis of the ACTG A5257 trial.

J Acquir Immune Defic Syndr 2019 Feb 13. Epub 2019 Feb 13.

: INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), PARIS, FRANCE.

Background: The restricted mean survival time (RMST) measures have not been used as primary measure of efficacy in HIV/AIDS clinical trials. In this work, we aim to compare analysis based on the difference in RMST (Δ-RMST) measure and two other treatment-effect measures in a recent HIV equivalence trial, and investigate the performance and characteristics of Δ-RMST-based analysis in a simulation study.

Setting: and methods: We reanalyzed a recent HIV equivalence trial (ACTG A5257 trial) with hazard ratio (HR) and Δ-RMST, and then compared the results with the original analysis based on risk difference estimated by Kaplan-Meier curves (RDKM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000001978DOI Listing
February 2019

Clinical outcomes of young black men receiving HIV medical care in the United States, 2009-2014.

J Acquir Immune Defic Syndr 2019 Feb 13. Epub 2019 Feb 13.

All authors are affiliated with Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: More than one-quarter of 2016 HIV diagnoses among blacks in the U.S. occurred among persons aged 15-24 years, and three-quarters were among men. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000001987DOI Listing
February 2019

Toe systolic pressures and toe-brachial indices: uses, abuses, and shades of gray.

Authors:
Robert Trevethan

Blood Press Monit 2019 Feb 15. Epub 2019 Feb 15.

Independent Academic Researcher, Albury, New South Wales, Australia.

This article commences with arguments that toe systolic pressure (TSP) should be used as a means of diagnosing low blood pressure in relation to the prospect of wound nonhealing and amputation risk, that the toe-brachial index (TBI) should be used as a means of screening for peripheral artery disease, and that those specific uses for TSPs and TBIs should not be confused with each other. Problems associated with measurement of TSPs and TBIs are described, an attempt is made to establish abnormal threshold values for each, and tables are presented as aids to decision making while also indicating the need to take uncertainties into account. A possible role for TBIs in monitoring pedal vascular supply is given consideration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MBP.0000000000000372DOI Listing
February 2019

Activated dendritic cells and monocytes in HIV immunological non-responders; HIV-induced IP-10 correlates with low future CD4 recovery.

AIDS 2019 Feb 14. Epub 2019 Feb 14.

Department of Infectious Diseases, Oslo University Hospital, Norway.

Objective: To explore monocyte and dendritic cell (DC) immune responses, and their association with future CD4 gain in treated HIV patients with suboptimal CD4 recovery.

Design: A cross-sectional study of HIV-infected, virally suppressed individuals on antiretroviral therapy (ART) for ≥24 months; 41 immunological non-responders (INR) (CD4 < 400 cells/μL) and 26 immunological responders (IR) (CD4 > 600 cells/μL). Ten HIV-infected ART-naive and ten HIV-negative healthy persons served as controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000002173DOI Listing
February 2019

Human Seroprevalence to 11 Zoonotic Pathogens in the U.S. Arctic, Alaska.

Vector Borne Zoonotic Dis 2019 Feb 21. Epub 2019 Feb 21.

1 Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska.

Background: Due to their close relationship with the environment, Alaskans are at risk for zoonotic pathogen infection. One way to assess a population's disease burden is to determine the seroprevalence of pathogens of interest. The objective of this study was to determine the seroprevalence of 11 zoonotic pathogens in people living in Alaska. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/vbz.2018.2390DOI Listing
February 2019

Integrated and differentiated methadone and HIV care for people who use drugs: a qualitative study in Kenya with implications for implementation science.

Health Policy Plan 2019 Feb 20. Epub 2019 Feb 20.

Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.

Integrating methadone and HIV care is a priority in many low- and middle-income settings experiencing a growing challenge of HIV epidemics linked to injecting drug use. There is as yet little understanding of how to integrate methadone and HIV care in these settings and how such services can be implemented; such a gap reflects, in part, limitations in theorizing an implementation science of integrated care. In response, we qualitatively explored the delivery of methadone after its introduction in Kenya to understand integration with HIV care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/heapol/czz002DOI Listing
February 2019

Changes Over Time in HIV Prevalence and Sexual Behaviour Among Young Female Sex-Workers in 14 Sites in Zimbabwe, 2013-2016.

AIDS Behav 2019 Feb 20. Epub 2019 Feb 20.

Centre for Sexual Health, HIV/AIDS Research (CeSHHAR) Zimbabwe, 09 Monmouth Road, Avondale West, Harare, Zimbabwe.

Young female sex-workers (FSW) aged 18-24 are at high risk of HIV due to high numbers of sexual partners, difficulty negotiating condom use, increased risk of gender-based violence, and limited access to services. Here we describe changes in sexual behaviours among young FSW across Zimbabwe between 2013 and 2016, and risk factors for prevalent HIV in 2013 and 2016. FSW ≥ 18 years were recruited using respondent-driven sampling in 14 sites across Zimbabwe in 2013 and 2016 as part of the SAPPH-IRe trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10461-019-02410-1DOI Listing
February 2019

Latex films with gradients in crosslink density created by small-molecule-based auto-stratification.

Eur Phys J E Soft Matter 2019 Feb 21;42(2):21. Epub 2019 Feb 21.

Institute of Physical Chemistry, Clausthal University of Technology, 38678, Clausthal-Zellerfeld, Germany.

A suitable balance of convective and diffusive transport of small molecules contained in the liquid phase of a drying latex film leads to auto-stratification and to functionally graded films. Differing from blends of latex particles, which may also experience drying-induced segregation, small molecules retain their mobility after the particles have touched and have formed an elastically coupled network. The use of a thickener, which turns the dispersion into a weak gel and prevents the free flow of particles, is compatible with this approach (and even advantageous). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1140/epje/i2019-11781-3DOI Listing
February 2019

Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines.

Cell Tissue Res 2019 Feb 20. Epub 2019 Feb 20.

Production Animal Health (PAH), Faculty of Veterinary Medicine, University of Calgary, HSC 2519, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada.

The intestinal mucosa contributes to frontline gut defenses by forming a barrier (physical and biochemical) and preventing the entry of pathogenic microbes. One innate role of the human colonic epithelium is to secrete cathelicidin, a peptide with broad antimicrobial and immunomodulatory functions. In this study, the effect of cathelicidin in the maintenance of epithelial integrity, Toll-like receptor recognition, bacterial invasion and initiation of inflammatory response against Salmonella typhimurium is investigated in cultured human colonic epithelium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00441-018-02984-7DOI Listing
February 2019

Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults.

Front Pediatr 2019 6;7:16. Epub 2019 Feb 6.

Department of Pediatrics-Rady Children's Hospital San Diego, University of California, San Diego, San Diego, CA, United States.

Due to potential disease and drug interactions, the appropriate sertraline starting dose and titration range may require adjustment in pediatric patients living with HIV. This is the first report of sertraline pharmacokinetics in HIV-infected youth. IMPAACT P1080 was a multicenter pilot study describing psychiatric medication pharmacokinetics in HIV-infected and uninfected youth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372542PMC
February 2019

An Unusual Case of Pulmonary Cryptococcus.

Cureus 2018 Dec 8;10(12):e3707. Epub 2018 Dec 8.

Internal Medicine, Seton Hall University-Hackensack Meridian School of Medicine, St. Francis Program, Trenton, USA.

Cryptococcal infections are caused by encapsulated fungi Cryptococcus gattii and C. neoformans. Inhalation commonly causes innocuous colonization but may cause meningitis or disseminated disease via hematogenous spread. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372251PMC
December 2018

A survey of the training of traditional, complementary, and alternative medicine in universities in Thailand.

J Multidiscip Healthc 2019 4;12:119-124. Epub 2019 Feb 4.

Department of Research and Innovation, University of Limpopo, Turfloop, South Africa,

Background: Traditional, complementary, and alternative medicine (TCAM) is popularly used by the Thai population. The aim of this study was to determine whether undergraduate medical curricula included TCAM and, if so, to ascertain what kind of education was provided. In addition, where undergraduate degrees in TCAM were offered, the type of TCAM curricula, research, training, and collaboration were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JMDH.S189644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366357PMC
February 2019