585 results match your criteria AIDS Research and Therapy[Journal]


An observational study of initial HIV RNA decay following initiation of combination antiretroviral treatment during pregnancy.

AIDS Res Ther 2020 Jul 13;17(1):41. Epub 2020 Jul 13.

Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, W2 1PG, UK.

Background: In pregnancy, reduction of HIV plasma viral load (pVL) for the prevention of vertical transmission is time-constrained. The study primary objective is to investigate factors associated with faster initial HIV RNA half-life decay when combination antiretroviral treatment (cART) is initiated in pregnancy.

Methods: This was a multicentre, retrospective, observational study, conducted in south England, United Kingdom, between August 2001 and February 2018. Read More

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http://dx.doi.org/10.1186/s12981-020-00297-wDOI Listing

Addressing advanced HIV disease and mortality in global HIV programming.

AIDS Res Ther 2020 Jul 10;17(1):40. Epub 2020 Jul 10.

Division of Global HIV and TB, Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, US 1-1, Atlanta, GA, 30329, USA.

Introduction: The US President's Emergency Plan for AIDS Relief (PEPFAR) was launched to increase access to antiretroviral treatment (ART) among people living with HIV (PLHIV) and to prevent new HIV infections globally. As new infections have decreased in many PEPFAR-supported countries, PEPFAR is increasingly focusing on understanding and decreasing mortality among PLHIV, specifically by addressing advanced HIV disease (AHD) and its attendant opportunistic infections (OIs). Several developments in identifying AHD, in preventing, diagnosing, and treating selected OIs, and in PEPFAR's support for mortality surveillance make this an opportune moment for PEPFAR to address HIV-related mortality. Read More

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http://dx.doi.org/10.1186/s12981-020-00296-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348123PMC

Antiretroviral treatment failure and associated factors among HIV patients on first-line antiretroviral treatment in Sekota, northeast Ethiopia.

AIDS Res Ther 2020 Jul 10;17(1):39. Epub 2020 Jul 10.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, PO Box 196, Gondar, Ethiopia.

Background: Antiretroviral treatment has played a pivotal role in the reduction of HIV/AIDS-related morbidity and mortality. However, treatment options can be impaired by the development of antiretroviral treatment failure. Regular monitoring of the Human Immunodeficiency Virus treatment outcome via viral load tests is the key approach. Read More

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http://dx.doi.org/10.1186/s12981-020-00294-zDOI Listing

Human immunodeficiency virus-associated vacuolar encephalomyelopathy with granulomatous-lymphocytic interstitial lung disease improved after antiretroviral therapy: a case report.

AIDS Res Ther 2020 Jul 9;17(1):38. Epub 2020 Jul 9.

Department of Respiratory Medicine, Nagasaki University Hospital, Sakamoto 1-7-1, Nagasaki City, Nagasaki, 852-8501, Japan.

Background: Vacuolar encephalomyelopathy, a disregarded diagnosis lately, was a major neurological disease in the terminal stages of human immunodeficiency virus (HIV)-1 infection in the pre-antiretroviral therapy (ART) era. Granulomatous-lymphocytic interstitial lung disease (GLILD) was classically identified as a non-infectious complication of common variable immunodeficiency; however, it is now being recognized in other immunodeficiency disorders. Here, we report the first case of GLILD accompanied by vacuolar encephalomyelopathy in a newly diagnosed HIV-infected man. Read More

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http://dx.doi.org/10.1186/s12981-020-00295-yDOI Listing

JC Polyomavirus, progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome: a review.

AIDS Res Ther 2020 Jul 6;17(1):37. Epub 2020 Jul 6.

Division of Infectious Diseases, Chongqing Public Health Medical Center, 109 Baoyu Road, Geleshan Town, Shapingba District, Chongqing, 400036, People's Republic of China.

The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individuals. The spectrum of underlying reasons for the systemic immunosuppression that permits JCV infection in the central nervous system has evolved over the past 2 decades, and therapeutic immunosuppression arousing JCV infection in the brain has become increasingly prominent as a trigger for PML. Effective immune restoration subsequent to human immunodeficiency virus-related suppression is now recognized as a cause for unexpected deterioration of symptoms in patients with PML, secondary to a rebound inflammatory phenomenon called immune reconstitution inflammatory syndrome, resulting in significantly increased morbidity and mortality in a disease already infamous for its lethality. Read More

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http://dx.doi.org/10.1186/s12981-020-00293-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338111PMC

Food insecurity and the risk of depression in people living with HIV/AIDS: a systematic review and meta-analysis.

AIDS Res Ther 2020 Jun 22;17(1):36. Epub 2020 Jun 22.

Research and Training Department, Amanuel Mental Specialized Hospital Addis Ababa, PO BOX 1971, Addis Ababa, Ethiopia.

Background: The link between food insecurity and depression in people living with HIV/AIDS (PLWHA) has been explored in numerous studies; however, the existing evidence is inconclusive due to inconsistent results. Therefore, the objective of this systematic review and meta-analysis is to examine the relationship between food insecurity and depression in PLWHA.

Methods: We systematically searched PubMed, EMBASE, and Scopus to identify relevant studies. Read More

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http://dx.doi.org/10.1186/s12981-020-00291-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310141PMC

Adolescents living with HIV, complex needs and resilience in Blantyre, Malawi.

AIDS Res Ther 2020 Jun 22;17(1):35. Epub 2020 Jun 22.

School of Public Health, The University of the Witwatersrand, Wits Education Campus. 27 St. Andrews Road, Parktown, Johannesburg, 2193, South Africa.

Background: Adolescents living with HIV (ALHIV) in Malawi experience multiple challenges associated with their illness and various social, environmental, economic and cultural factors. In exploring their various medical concerns and social vulnerabilities, we consider the role of multiple services in creating a pathway for resilience.

Methods: Multiple methods and case studies allowed for triangulation of evidence and provided a holistic understanding of resilience among adolescents with complex needs. Read More

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http://dx.doi.org/10.1186/s12981-020-00292-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310029PMC

Determinants of long acting contraceptive utilization among HIV positive reproductive age women attending care at art clinics of public health facilities in Arba Minch town, Southern Ethiopia, 2019: a case control study.

AIDS Res Ther 2020 Jun 15;17(1):34. Epub 2020 Jun 15.

Department of Anesthesia, Menelik II College of Medical & Health Science, Kotebe Metropolitan University, Addis Ababa, Ethiopia.

Background: Long acting and permanent contraceptive methods by far are the most effective, very safe and convenient methods than short acting contraceptive methods. But in less developed countries, use of long acting reversible contraceptive or permanent methods (LARCs/PMs) is very low. Therefore the aim of this study was to identify determinants of long acting contraceptive method utilization among HIV positive reproductive age women. Read More

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http://dx.doi.org/10.1186/s12981-020-00288-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296955PMC

The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau.

AIDS Res Ther 2020 12;17:33. Epub 2020 Jun 12.

The Department of Clinical Sciences Lund, Lund University, Infektionskliniken Skånes Universitetssjukhus Lund, Hälsogatan 3, 221 85 Lund, Sweden.

Introduction: Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in West Africa. In the current study we describe the HIV Care continuum and prevalence of HIVDR among FSW in Guinea-Bissau. Read More

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http://dx.doi.org/10.1186/s12981-020-00290-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291728PMC

The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau.

AIDS Res Ther 2020 Jun 12;17(1):33. Epub 2020 Jun 12.

The Department of Clinical Sciences Lund, Lund University, Infektionskliniken Skånes Universitetssjukhus Lund, Hälsogatan 3, 221 85, Lund, Sweden.

Introduction: Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in West Africa. In the current study we describe the HIV Care continuum and prevalence of HIVDR among FSW in Guinea-Bissau. Read More

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http://dx.doi.org/10.1186/s12981-020-00290-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291728PMC

Assessment of two POC technologies for CD4 count in Morocco.

AIDS Res Ther 2020 10;17:31. Epub 2020 Jun 10.

National Reference Laboratory for HIV, Department of Virology, National Institute of Hygiene, Rabat, Morocco.

Background: In the era of "test and treat strategy", CD4 testing remains an important tool for monitoring HIV-infected individuals. Since conventional methods of CD4 count measurement are costly and cumbersome, POC CD4 counting technique are more affordable and practical for countries with limited resources. Before introducing such methods in Morocco, we decided to assess their reliability. Read More

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http://dx.doi.org/10.1186/s12981-020-00289-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285615PMC

Social response to the delivery of HIV self-testing in households: experiences from four Zambian HPTN 071 (PopART) urban communities.

AIDS Res Ther 2020 Jun 11;17(1):32. Epub 2020 Jun 11.

Zambart, School of Public Health, University of Zambia, Lusaka, Zambia.

Background: Door-to-door distribution of HIV self-testing kits (HIVST) has the potential to increase uptake of HIV testing services (HTS). However, very few studies have explored the social response to and implications of door-to-door including secondary distribution of HIVST on household relations and the ability of individuals to self-test with or without supervision within households.

Methods: A CRT of HIVST distribution was nested within the HPTN 071 (PopART) trial, in four Zambian communities randomised to receive the PopART intervention. Read More

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http://dx.doi.org/10.1186/s12981-020-00287-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288417PMC

Assessment of two POC technologies for CD4 count in Morocco.

AIDS Res Ther 2020 Jun 10;17(1):31. Epub 2020 Jun 10.

National Reference Laboratory for HIV, Department of Virology, National Institute of Hygiene, Rabat, Morocco.

Background: In the era of "test and treat strategy", CD4 testing remains an important tool for monitoring HIV-infected individuals. Since conventional methods of CD4 count measurement are costly and cumbersome, POC CD4 counting technique are more affordable and practical for countries with limited resources. Before introducing such methods in Morocco, we decided to assess their reliability. Read More

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http://dx.doi.org/10.1186/s12981-020-00289-wDOI Listing

Habit formation in support of antiretroviral medication adherence in clinic-enrolled HIV-infected adults: a qualitative assessment using free-listing and unstructured interviewing in Kampala, Uganda.

AIDS Res Ther 2020 Jun 8;17(1):30. Epub 2020 Jun 8.

RAND Corporation, 1776 Main Street, Santa Monica, CA, USA.

Background: Despite initial high motivation, individuals receiving antiretroviral therapy (ART) for several years may experience incomplete adherence over time, increasing their risk of HIV-related morbidity and mortality. Habits, defined as automatic and regular practices, do not rely on conscious effort, and may therefore support high long-term ART adherence.

Methods: This qualitative study contributes to the evidence on how clients with adherence problems remember and form habits to take ART medications. Read More

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http://dx.doi.org/10.1186/s12981-020-00283-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278190PMC

Retention in care in aging adults with a dual diagnosis of HIV infection and type 2 diabetes mellitus: a longitudinal retrospective cross-sectional study.

AIDS Res Ther 2020 May 29;17(1):29. Epub 2020 May 29.

School of Nursing, Hanyang University, 222 Wangsimni-ro, Sageun-dong, Seongdong-gu, Seoul, South Korea.

Background: This study aimed to investigate the measures of retention in care (RIC) in persons living with HIV (PLWH) and type 2 diabetes mellitus (T2DM) by age group (younger vs. older adults).

Methods: This was a longitudinal retrospective cross-sectional study that used secondary data from the Center for AIDS Research Network of Integrated Clinical Systems (CNICS). Read More

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http://dx.doi.org/10.1186/s12981-020-00286-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260810PMC

Views among Malawian women about joining HIV prevention clinical trials when pregnant.

AIDS Res Ther 2020 May 27;17(1):27. Epub 2020 May 27.

Center for Bioethics and Department of Social Medicine, University of North Carolina at Chapel Hill, 333 S. Columbia Street, Campus Box 7240, Chapel Hill, NC, 27599, USA.

Background: The pressing need to expand the biomedical HIV prevention evidence base during pregnancy is now increasingly recognized. Women's views regarding participation in such trials and initiating PrEP while pregnant are critical to inform evolving policy and best practices aimed at responsibly expanding evidence-based access for this population.

Methods: We conducted 35 semi-structured interviews with reproductive-aged women in Malawi in the local language, Chichewa. Read More

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http://dx.doi.org/10.1186/s12981-020-00271-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251879PMC

A prospective cohort study of outcomes for isoniazid prevention therapy: a nested study from a national QI collaborative in Uganda.

AIDS Res Ther 2020 May 27;17(1):28. Epub 2020 May 27.

United States Agency for International Development (USAID), Kampala, Uganda.

Background: Tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection constitute a deadly infectious disease synergy disease and major public health problem throughout the world. The risk of developing active TB in people living with HIV (PLHIV) is 21 times higher than the rest of the world population. The overlap of latent TB infection and HIV infection has resulted in marked increases in TB incidence in countries with dual epidemics. Read More

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http://dx.doi.org/10.1186/s12981-020-00285-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254658PMC

AIDS-associated Talaromyces marneffei central nervous system infection in patients of southwestern China.

AIDS Res Ther 2020 May 26;17(1):26. Epub 2020 May 26.

Yunnan Provincial Hospital of Infectious Disease/Yunnan AIDS Care Center (YNACC), Kunming, 650301, China.

Background: The clinical and laboratory characteristics of AIDS-associated Talaromyces marneffei infection, a rare but a fatal mycosis disease of the central nervous system, remain unclear.

Case Presentation: Herein, we conducted a retrospective study of ten AIDS patients with cerebrospinal fluid culture-confirmed central nervous system infection caused by Talaromyces marneffei. All 10 patients were promptly treated with antifungal treatment for a prolonged duration and early antiviral therapy (ART). Read More

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http://dx.doi.org/10.1186/s12981-020-00281-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249401PMC

Prediabetes among HIV-infected individuals receiving antiretroviral therapy: prevalence, diagnostic tests, and associated factors.

AIDS Res Ther 2020 May 24;17(1):25. Epub 2020 May 24.

Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 111 Moo 14, Bang Pla, Bang Phli, Samut Prakan, 10540, Thailand.

Background: Metabolic complications in human immunodeficiency virus (HIV)-infected individuals are common. Prediabetes represents a high risk for future diabetes development. This study aimed to determine the prevalence, diagnostic methods, and associated factors of prediabetes among HIV-infected individuals receiving antiretroviral therapy (ART). Read More

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http://dx.doi.org/10.1186/s12981-020-00284-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247133PMC

Drug use and antiretroviral therapy (ART) interactions: a qualitative study to explore the knowledge, beliefs, adherence, and quality of life of people living with HIV taking ART and illicit drugs.

AIDS Res Ther 2020 May 24;17(1):24. Epub 2020 May 24.

Spanish Interdisciplinary Aids Society (Sociedad Española Interdisciplinaria del Sida, SEISIDA), Madrid, Spain.

Background: To explore the use of illicit drugs by people living with HIV (PLHIV) taking antiretroviral therapy (ART) and their relationship with variables relevant to the management of HIV infection, such as knowledge and beliefs about drug-drug interactions (DDIs), ART adherence, quality of life (QoL), and use of health-care resources.

Methods: 21 PLHIV in Spain who concomitantly took illicit drugs and ART participated in this qualitative study. Eight experts collaborated in the design of the semi-structured interview guide which explored the following topics: illicit drug use, knowledge and beliefs about DDIs and their impact on ART adherence, the effects of using illicit drugs on health, QoL, and use of health-care resources. Read More

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http://dx.doi.org/10.1186/s12981-020-00279-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245822PMC

Efficacy and safety of abacavir/lamivudine plus rilpivirine as a first-line regimen in treatment-naïve HIV-1 infected adults.

AIDS Res Ther 2020 May 21;17(1):23. Epub 2020 May 21.

National Centre for Infectious Diseases, Singapore, Singapore.

Background: The anti-retroviral combination of abacavir/lamivudine plus rilpivirine (ABC/3TC/RPV) is not recommended by international guidelines as the first-line regimen. However, it is potent, well-tolerated, and affordable, especially in resource-limited settings. This study evaluates the efficacy and safety of ABC/3TC/RPV as an initial regimen for treatment-naïve HIV-1 infected patients. Read More

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http://dx.doi.org/10.1186/s12981-020-00272-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243331PMC
May 2020
1.841 Impact Factor

Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi.

AIDS Res Ther 2020 May 20;17(1):22. Epub 2020 May 20.

Lighthouse Clinic, Lilongwe, Malawi.

Background: Pre-treatment drug resistance (PDR) among antiretroviral drug-naïve people living with HIV (PLHIV) represents an important indicator for the risk of treatment failure and the spread of drug resistant HIV variants. We assessed the prevalence of PDR and treatment outcomes among adults living with HIV-1 in Lilongwe, Malawi.

Methods: We selected 200 participants at random from the Lighthouse Tenofovir Cohort Study (LighTen). Read More

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http://dx.doi.org/10.1186/s12981-020-00282-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240935PMC

Diffusion tensor imaging point to ongoing functional impairment in HIV-infected children at age 5, undetectable using standard neurodevelopmental assessments.

AIDS Res Ther 2020 May 19;17(1):20. Epub 2020 May 19.

Family Clinical Research Unit, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, University of Stellenbosch, Tygerberg, South Africa.

Background: Perinatal HIV infection negatively impacts cognitive functioning of children, main domains affected are working memory, processing speed and executive function. Early ART, even when interrupted, improves neurodevelopmental outcomes. Diffusion tension imaging (DTI) is a sensitive tool assessing white matter damage. Read More

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http://dx.doi.org/10.1186/s12981-020-00278-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236356PMC

Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC).

AIDS Res Ther 2020 May 19;17(1):21. Epub 2020 May 19.

Department of Physical Therapy, University of Toronto, 500 University Avenue, Room 160, Toronto, ON, Canada.

Background: People living with HIV are living longer, and can experience physical, mental and social health challenges associated with aging and multimorbidity. Rehabilitation is well positioned to address disability and maximize healthy aging. An international collaborative network, called the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC), works to guide this emerging field. Read More

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http://dx.doi.org/10.1186/s12981-020-00280-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236512PMC

The effect of "universal test and treat" program on HIV treatment outcomes and patient survival among a cohort of adults taking antiretroviral treatment (ART) in low income settings of Gurage zone, South Ethiopia.

AIDS Res Ther 2020 May 18;17(1):19. Epub 2020 May 18.

Department of Pharmacy, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia.

Background: Through universal "test and treat approach" (UTT) it is believed that HIV new infection and AIDS related death will be reduced at community level and through time HIV can be eliminated. With this assumption the UTT program was implemented since 2016. However, the effect of this program in terms of individual patient survival and treatment outcome was not assessed in relation to the pre-existing defer treatment approach. Read More

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http://dx.doi.org/10.1186/s12981-020-00274-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236275PMC
May 2020
1.841 Impact Factor

Survival of people aged 50 years and older by HIV and HIV treatment status: findings from three waves of the SAGE-Wellbeing of Older People Study (SAGE-WOPS) in Uganda.

AIDS Res Ther 2020 May 14;17(1):17. Epub 2020 May 14.

Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine, Uganda Research Unit, P.O Box 49, Entebbe, Uganda.

Background: Data on the survival status of older adults on antiretroviral treatment (ART) are scarce in sub-Saharan Africa. The objective of this study was to determine the survival status of people aged 50 years and older who were HIV-negative, HIV-positive not on ART, and HIV-positive on ART.

Methods: We used three waves of data from the World Health Organisation Study on Global Ageing and adult health- Well Being of Older People Study cohort in Uganda, conducted in 2009, 2012-2013 and 2015-2016. Read More

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http://dx.doi.org/10.1186/s12981-020-00276-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226937PMC

Impact of WHO guidelines on trends in HIV testing and ART initiation among children living with HIV in Zambia.

AIDS Res Ther 2020 May 14;17(1):18. Epub 2020 May 14.

Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.

Background: About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We examined trends in HIV testing and ART initiation in Zambia.

Methods: We conducted a retrospective cohort study using routinely collected patient level data from 496 health facilities across Zambia. Read More

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http://dx.doi.org/10.1186/s12981-020-00277-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226945PMC
May 2020
1.841 Impact Factor

Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: an open-label, randomized, single center study in south Florida.

AIDS Res Ther 2020 May 13;17(1):16. Epub 2020 May 13.

Division of Infectious Diseases, Memorial Healthcare System, 5647 Hollywood Boulevard, Hollywood, FL, 33021, USA.

Background: People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic.

Methods: ART-naïve PHIV receiving care through the clinic's Ryan White HIV/AIDS Program were enrolled and randomly assigned to the intervention or control groups with a 1:1 ratio. Read More

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http://dx.doi.org/10.1186/s12981-020-00275-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222430PMC

Programme quality indicators of HIV drug resistance among adolescents in urban versus rural settings of the centre region of Cameroon.

AIDS Res Ther 2020 May 12;17(1):14. Epub 2020 May 12.

Virology Laboratory, Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), P.O BOX: 3077, Messa, Yaoundé, Cameroon.

Background: The high rate of mortality among HIV-vertically infected adolescents might be favoured by HIV drug resistance (HIVDR) emergence, which calls for timeous actions in this underserved population. We thus sought to evaluate program quality indicators (PQIs) of HIVDR among HIV-vertically infected adolescents on antiretroviral therapy (ART).

Methods: A study was conducted in the Centre region of Cameroon among adolescents (10-19 years) receiving ART in two urban (The Mother-Child Centre of the Chantal BIYA Foundation, the National Social Welfare Hospital) and three rural (Mfou District Hospital, Mbalmayo District Hospital and Nkomo Medical Center) health facilities. Read More

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http://dx.doi.org/10.1186/s12981-020-00270-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216382PMC
May 2020
1.841 Impact Factor

Daily variations of gut microbial translocation markers in ART-treated HIV-infected people.

AIDS Res Ther 2020 May 12;17(1):15. Epub 2020 May 12.

Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, 1001 Blvd Décarie, Montreal, QC, Canada.

Background: Increased intestinal barrier permeability and subsequent gut microbial translocation are significant contributors to inflammatory non-AIDS comorbidities in people living with HIV (PLWH). Evidence in animal models have shown that markers of intestinal permeability and microbial translocation vary over the course of the day and are affected by food intake and circadian rhythms. However, daily variations of these markers are not characterized yet in PLWH. Read More

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http://dx.doi.org/10.1186/s12981-020-00273-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216536PMC

Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4:CD8 T-cell ratio in treated HIV-1 infection.

AIDS Res Ther 2020 04 15;17(1):13. Epub 2020 Apr 15.

Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20, W10, Kita-ku, Sapporo, 001-0020, Japan.

Background: The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4:CD8 ratio normalisation in people living with HIV (PLWH) on effective antiretroviral therapy (ART); and to examine whether these polymorphisms influence the composition of T lymphocyte compartments in long-term treated HIV-1 infection.

Methods: A cross-sectional study in PLWH enrolled into the Mater Immunology study. We performed IFNL genotyping on stored samples and evaluated the association of IFNL single-nucleotide polymorphisms (rs368234815 and rs12979860) with CD4:CD8 ratio normalization (> 1) and expanded CD4 and CD8 T-cell subsets; CD45ROCD62L (central-memory), CD45RO CD62L(effector-memory) and CD45ROCD62L (naïve), using logistic and linear regression models, respectively. Read More

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http://dx.doi.org/10.1186/s12981-020-00269-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194102PMC

Real-world adherence and persistence for newly-prescribed HIV treatment: single versus multiple tablet regimen comparison among US medicaid beneficiaries.

AIDS Res Ther 2020 04 1;17(1):12. Epub 2020 Apr 1.

Columbia University, New York, NY, USA.

Background: Once-daily, single-tablet regimens (STRs) have been associated with improved patient outcomes compared to multi-tablet regimens (MTRs). This study evaluated real world adherence and persistence of HIV antiretroviral therapy (ART), comparing STRs and MTRs.

Methods: Adult Medicaid beneficiaries (aged ≥ 18 years) initiating ART with ≥ 2 ART claims during the identification period (January 1, 2015-December 31, 2016) and continuous health plan enrollment for a 12-month baseline period were included. Read More

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http://dx.doi.org/10.1186/s12981-020-00268-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110826PMC

Contemporary issues and new challenges in chronic kidney disease amongst people living with HIV.

AIDS Res Ther 2020 03 16;17(1):11. Epub 2020 Mar 16.

Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Chronic kidney disease (CKD) is a comorbidity of major clinical significance amongst people living with HIV (PLWHIV) and is associated with significant morbidity and mortality. The prevalence of CKD is rising, despite the widespread use of antiretroviral therapy (ART) and is increasingly related to prevalent non-infectious comorbidities (NICMs) and antiretroviral toxicity. There are great disparities evident, with the highest prevalence of CKD among PLWHIV seen in the African continent. Read More

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http://dx.doi.org/10.1186/s12981-020-00266-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075008PMC

Metformin effect on gut microbiota: insights for HIV-related inflammation.

AIDS Res Ther 2020 03 10;17(1):10. Epub 2020 Mar 10.

Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, 1001 Blvd Décarie, Montréal, QC, Canada.

The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Read More

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http://dx.doi.org/10.1186/s12981-020-00267-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063824PMC

HIV drug resistance in patients in China's national HIV treatment programme who have been on first-line ART for at least 9 months.

AIDS Res Ther 2020 03 5;17(1). Epub 2020 Mar 5.

State Key Laboratory for Infectious Disease Prevention and Control (SKLID), National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 155 Changbai Road, Changping District, Beijing, 102206, People's Republic of China.

Background: The aim of this study was to assess trends in drug resistance and associated clinical and programmatic factors at a national level during the rapid scale up of ART.

Methods: Logistic regression was used to identify the factors associated with HIVDR. Variables associated with drug resistance in multivariable logistic regression were included in the Cochran-Armitage test for trend. Read More

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http://dx.doi.org/10.1186/s12981-020-00264-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059326PMC
March 2020
1.841 Impact Factor

Comparing self-reported medication adherence measures with hair antiretroviral concentration among people living with HIV in Guangxi, China.

AIDS Res Ther 2020 03 2;17(1). Epub 2020 Mar 2.

Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi, China.

Background: Antiretroviral adherence is essential to HIV treatment efficacy. Various self-reported measures are commonly used for assessing antiretroviral adherence. Limited data are available regarding the validity of those self-reported measures in comparison with long-term objective biomarkers of adherence measures such as hair measures. Read More

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http://dx.doi.org/10.1186/s12981-020-00265-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053048PMC

Epidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in Nigeria.

AIDS Res Ther 2020 02 17;17(1). Epub 2020 Feb 17.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Expanded access to combination antiretroviral therapy (cART) throughout sub-Saharan Africa over the last decade has remarkably improved the prognosis of persons living with HIV (PLWH). However, some PLWH experience virologic rebound after a period of viral suppression, usually followed by selection of drug resistant virus. Determining factors associated with drug resistance can inform patient management and healthcare policies, particularly in resource-limited settings where drug resistance testing is not routine. Read More

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http://dx.doi.org/10.1186/s12981-020-0261-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027291PMC
February 2020
1.841 Impact Factor

HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.

AIDS Res Ther 2020 02 10;17(1). Epub 2020 Feb 10.

Molecular Virology Unit, Infectious Diseases Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Dominguez, Tlalpan, P.O. Box 14080, Mexico City, Mexico.

Background: In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including other integrase inhibitors. In this context, real-life data about the resistance and cross-resistance pathways between integrase inhibitors is limited. Read More

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http://dx.doi.org/10.1186/s12981-020-0262-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011548PMC
February 2020

HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis.

AIDS Res Ther 2020 02 7;17(1). Epub 2020 Feb 7.

HIV/AIDS & Global Health Research Programme, and Department of Microbiology, University of Venda, Thohoyandou, 0950, South Africa.

Background: Entry inhibitors, such as Maraviroc, hold promise as components of HIV treatment and/or pre-exposure prophylaxis in Africa. Maraviroc inhibits the interaction between HIV Envelope gp120 V3-loop and CCR5 coreceptor. HIV-1 subtype C (HIV-1-C) is predominant in Southern Africa and preferably uses CCR5 co-receptor. Read More

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http://dx.doi.org/10.1186/s12981-020-0263-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006146PMC
February 2020

Migrant female sex workers working at the Sino-Vietnamese border for a short time have a higher risk of HIV transmission: a consecutive cross-sectional study.

AIDS Res Ther 2020 02 7;17(1). Epub 2020 Feb 7.

Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Objectives: For migrant female sex workers (FSWs) at the Sino-Vietnamese border, the impact of work time in their current location on the spread of HIV/AIDS is not clear.

Methods: Data were collected from the Sino-Vietnamese border cities of Guangxi, China. Migrant FSWs working in these cities were studied. Read More

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http://dx.doi.org/10.1186/s12981-020-0260-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006200PMC
February 2020
1.841 Impact Factor

HIV treatment in Guinea-Bissau: room for improvement and time for new treatment options.

AIDS Res Ther 2020 02 4;17(1). Epub 2020 Feb 4.

Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.

Despite advances in the treatment quality of HIV throughout the world, several countries are still facing numerous obstacles in delivering HIV treatment at a sufficiently high quality, putting patients' lives in jeopardy. The aim of this status article is to give an overview of HIV treatment outcomes in the West African country, Guinea-Bissau, and to assess how newer treatment strategies such as long-acting injectable drugs or an HIV cure may limit or stop the HIV epidemic in this politically unstable and low-resource setting. Several HIV cohorts in Guinea-Bissau have been established and are used as platforms for epidemiological, virological, immunological and clinical studies often with a special focus on HIV-2, which is prevalent in the country. Read More

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http://dx.doi.org/10.1186/s12981-020-0259-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998355PMC
February 2020

Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda.

AIDS Res Ther 2020 01 31;17(1). Epub 2020 Jan 31.

Center for AIDS Research Laboratories, Joint Clinical Research Center, P.O. Box 10005, Kampala, Uganda.

Background: Resistance to antiretroviral drugs is a major challenge among Human Immunodeficiency Virus (HIV) positive patients receiving antiretroviral therapy (ART). Mutations that arise as a result of this are diverse across the various drugs, drug classes, drug regimens and subtypes. In Uganda, there is a paucity of information on how these mutations differ among the different drug regimens and the predominant HIV-1 subtypes. Read More

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http://dx.doi.org/10.1186/s12981-020-0258-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995161PMC
January 2020

Neuropsychiatric outcomes before and after switching to dolutegravir-based therapy in an acute HIV cohort.

AIDS Res Ther 2020 01 7;17(1). Epub 2020 Jan 7.

Missouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, MO, USA.

Introduction: Dolutegravir (DTG)-based antiretroviral therapy (ART) is currently the first-line treatment for people living with HIV. Neuropsychiatric adverse events (NP-AEs) have been reported with DTG but neuropsychiatric symptoms have not been systemically quantified using structured scales. This study examined mood and cognitive parameters before and after a planned transition from non-DTG to DTG-based ART within a longitudinal study of acute HIV infection (AHI). Read More

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http://dx.doi.org/10.1186/s12981-019-0257-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945418PMC
January 2020
1.841 Impact Factor

Renal function change after switching tenofovir disoproxil fumarate for tenofovir alafenamide in the HIV-positive patients of a metropolitan sexual health service.

AIDS Res Ther 2019 12 7;16(1):40. Epub 2019 Dec 7.

Central Clinical School, University of Sydney, Sydney, NSW, Australia.

Background: Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched from TDF. The factors which predict improved renal function in patients switching from TDF to TAF have yet to be described. Read More

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http://dx.doi.org/10.1186/s12981-019-0256-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898922PMC
December 2019

Antiretroviral concentration measurements as an additional tool to manage virologic failure in resource limited settings: a case control study.

AIDS Res Ther 2019 12 6;16(1):39. Epub 2019 Dec 6.

Infectious Diseases Institute, Makerere University, College of Health Sciences, P. O. BOX 22418, Kampala, Uganda.

Background: Several studies demonstrate a correlation between sub-therapeutic concentrations of antiretroviral drugs and virologic failure. We examined the sensitivity, specificity and predictive values of sub-therapeutic drug levels in predicting viralogic failure.

Methods: This was a case control study with cases being samples of participants with virologic failure, and controls samples of participants with virologic suppression. Read More

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http://dx.doi.org/10.1186/s12981-019-0255-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898957PMC
December 2019

Low rates of prior HIV testing among HIV-positive adults accessing outpatient services in Eswatini.

AIDS Res Ther 2019 12 5;16(1):38. Epub 2019 Dec 5.

Department of Epidemiology, Mailman School of Public Health, New York, NY, USA.

Prior HIV testing and awareness of HIV-positive status were assessed among HIV-positive adults at 20 clinics in Eswatini. Of 2196 HIV-positive adults, 1183 (53.8%) reported no prior HIV testing, and 1948 (88. Read More

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http://dx.doi.org/10.1186/s12981-019-0254-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896727PMC
December 2019

Kidney transplant outcomes in HIV-positive patients: a systematic review and meta-analysis.

AIDS Res Ther 2019 11 20;16(1):37. Epub 2019 Nov 20.

Urology Institute, Capital Medical University, Beijing, China.

Background: Kidney transplantation is now a viable alternative to dialysis in HIV-positive patients who achieve good immunovirological control with the currently available antiretroviral therapy regimens. This systematic review and meta-analysis investigate the published evidence of outcome and risk of kidney transplantation in HIV-positive patients following the PRISMA guidelines.

Methods: Searches of PubMed, the Cochrane Library and EMBASE identified 27 cohort studies and 1670 case series evaluating the survival of HIV-positive kidney transplant patients published between July 2003 and May 2018. Read More

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http://dx.doi.org/10.1186/s12981-019-0253-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868853PMC
November 2019

Implementation of antiretroviral therapy (ART) in former Soviet Union countries.

AIDS Res Ther 2019 11 19;16(1):35. Epub 2019 Nov 19.

Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan.

Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for the development of strategies that focus on high-risk behaviors and practices responsible for the continued transmission of HIV in this region. Read More

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http://dx.doi.org/10.1186/s12981-019-0251-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865057PMC
November 2019

Viral suppression in adults, adolescents and children receiving antiretroviral therapy in Cameroon: adolescents at high risk of virological failure in the era of "test and treat".

AIDS Res Ther 2019 11 19;16(1):36. Epub 2019 Nov 19.

Chantal BIYA International Reference Centre for Research On HIV/AIDS Prevention and Management (CIRCB), Melen Road, PO BOX 3077, Yaounde, Cameroon.

Background: After the launching of the « Test & Treat » strategy and the wider accessibility to viral load (VL), evaluating virological success (VS) would help in meeting the UNAIDS targets by 2020 in Cameroon.

Setting And Methods: Cross-sectional study conducted in the Chantal BIYA International Reference Centre for research on HIV/AIDS prevention and management (CIRCB), Yaoundé, Cameroon; data generated between October 2016 and August 2017 amongst adults, adolescents and children at 12, 24, 36 and ≥ 48 months on ART. VS was defined as < 1000 copies/mL of blood plasma and controlled viremia as VL < 50 copies/mL. Read More

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http://dx.doi.org/10.1186/s12981-019-0252-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864925PMC
November 2019
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Immediate versus deferred antiretroviral therapy in HIV-infected patients presenting with acute AIDS-defining events (toxoplasmosis, Pneumocystis jirovecii-pneumonia): a prospective, randomized, open-label multicenter study (IDEAL-study).

AIDS Res Ther 2019 11 15;16(1):34. Epub 2019 Nov 15.

Infectious Diseases Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: To evaluate clinical outcomes after either immediate or deferred initiation of antiretroviral therapy in HIV-1-infected patients, presenting late with pneumocystis pneumonia (PCP) or toxoplasma encephalitis (TE).

Methods: Phase IV, multicenter, prospective, randomized open-label clinical trial. Patients were randomized into an immediate therapy arm (starting antiretroviral therapy (ART) within 7 days after initiation of OI treatment) versus a deferred arm (starting ART after completing the OI-therapy). Read More

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http://dx.doi.org/10.1186/s12981-019-0250-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857475PMC
November 2019