642 results match your criteria AIDS Research and Therapy[Journal]


Community-based HIV testing in The Netherlands: experiences of lay providers and end users at a rapid HIV test checkpoint.

AIDS Res Ther 2021 Jun 23;18(1):34. Epub 2021 Jun 23.

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.

Background: The AIDS Healthcare Foundation (AHF-Checkpoint) in The Netherlands offers rapid HIV testing for key populations by lay providers. We explored the experiences and needs of lay providers and end users of HIV testing at AHF-Checkpoint, taking into account the WHO 5C-(consent, confidentiality, counselling, correct-results, connection-to-care) criteria for HIV test services.

Methods: Qualitative evaluation with 15 semi-structured interviews conducted during 2020 with ten lay providers and five gay or bisexual end users. Read More

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High risk sexual behaviours associated with traditional beliefs about gender roles among men interested in medical male circumcision in South Africa.

AIDS Res Ther 2021 Jun 22;18(1):33. Epub 2021 Jun 22.

The Aurum Institute, Aurum House, The Ridge, 29 Queens Road, Parktown, Johannesburg, South Africa.

Background: Beliefs about gender roles and high-risk sexual behaviours underlie the human immunodeficiency virus (HIV) epidemic in South Africa. Yet, there is limited information on the relationships between beliefs about gender roles and risky sexual behaviours. Few studies have explored the association between beliefs about gender roles, high risk sexual behaviour, and health-seeking behaviour among men. Read More

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The transient effect of a peer support intervention to improve adherence among adolescents and young adults failing antiretroviral therapy in Harare, Zimbabwe: a randomized control trial.

AIDS Res Ther 2021 Jun 16;18(1):32. Epub 2021 Jun 16.

Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

Background: Adolescents and young adults living with HIV in sub Saharan Africa are at high risk of poor adherence to antiretroviral therapy (ART) and virologic failure (VF).

Methods: We conducted a randomized control trial among adolescents and young adults on ART with VF to assess the effectiveness of a community-based peer support intervention aimed at improving VF. Viral load (VL) levels were obtained at 12, 24 and 36 weeks. Read More

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Impact of COVID-19 pandemic on HIV viremia: a single-center cohort study in northern Italy.

AIDS Res Ther 2021 06 4;18(1):31. Epub 2021 Jun 4.

Division of Infectious and Tropical Diseases, ASST Spedali Civili, Brescia, Italy.

Background: Brescia Province, northern Italy, was one of the worst epicenters of the COVID-19 pandemic. The division of infectious diseases of ASST (Azienda Socio Sanitaria Territoriale) Spedali Civili Hospital of Brescia had to face a great number of inpatients with severe COVID-19 infection and to ensure the continuum of care for almost 4000 outpatients with HIV infection actively followed by us. In a recent manuscript we described the impact of the pandemic on continuum of care in our HIV cohort expressed as number of missed visits, number of new HIV diagnosis, drop in ART (antiretroviral therapy) dispensation and number of hospitalized HIV patients due to SARS-CoV-2 infection. Read More

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Changing trends in lipid profile and biomarkers of renal function and bone metabolism before and after switching from tenofovir disoproxil fumarate to tenofovir alafenamide: a prospective observational study.

AIDS Res Ther 2021 05 27;18(1):30. Epub 2021 May 27.

Department of Infection Control and Prevention, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.

Background: Antiretrovirals, including tenofovir, can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate it. Patients with HIV infection are administered antiretroviral drugs over a long term; thus, managing consequent adverse drug reactions, such as renal dysfunction and bone mineral loss, is important. Currently, highly sensitive biomarkers that can detect adverse drug reactions early have not been well studied. Read More

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Association between depression and HIV treatment outcomes in a US military population with HIV infection.

AIDS Res Ther 2021 05 12;18(1):29. Epub 2021 May 12.

Brooke Army Medical Center, 3551 Roger Brooke Drive, Fort Sam Houston, TX, 78234-6200, USA.

Background: Depression is common among HIV-infected individuals and may contribute to suboptimal adherence to antiretroviral therapy (ART) and subsequent inability to attain viral load (VL) suppression. We evaluated associations between depression, self-reported adherence, and longitudinal HIV treatment outcomes in US Military HIV Natural History Study (NHS) participants with and without depression.

Methods: Male NHS participants with available ICD-9 data for mental health diagnoses, Center for Epidemiological Studies Depression (CES-D) measures, and self-reported adherence (SRA) were included. Read More

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COVID-19 and HIV infection co-pandemics and their impact: a review of the literature.

AIDS Res Ther 2021 05 5;18(1):28. Epub 2021 May 5.

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Coronavirus disease 2019 (COVID-19) was first detected in December 2019. In March 2020, the World Health Organization declared COVID-19 a pandemic. People with underlying medical conditions may be at greater risk of infection and experience complications from COVID-19. Read More

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Predictors of mortality rate among adult HIV-positive patients on antiretroviral therapy in Metema Hospital, Northwest Ethiopia: a retrospective follow-up study.

AIDS Res Ther 2021 05 5;18(1):27. Epub 2021 May 5.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Globally Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is an ongoing public health issue associated with high morbidity and mortality. Efforts have been made to reduce HIV/AIDS-related morbidity and mortality by delivering antiretroviral therapy. However, the incidence and predictors of mortality in border areas like Metema were not investigated. Read More

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Virologic outcomes of switching to dolutegravir functional mono- or dual therapy with a non-cytosine nucleoside analog: a retrospective study of treatment-experienced, patients living with HIV.

AIDS Res Ther 2021 05 3;18(1):26. Epub 2021 May 3.

Orlando Immunology Center, 1707 North Mills Avenue, Orlando, FL, 32803, USA.

Background: Dolutegravir (DTG) monotherapy results in virologic failure and the development of DTG resistance. Here, we evaluated virologic outcomes of patients switched to DTG functional mono- or dual therapy with a non-cytosine nucleoside analog (NA).

Methods: This retrospective, single center study included treatment-experienced patients switched to regimens containing ≥ 2 antiretrovirals between 8/13/13-11/22/14 who were later found to be on DTG functional mono- or dual therapy with a non-cytosine NA based on historical genotypes. Read More

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Integrase inhibitors versus efavirenz combination antiretroviral therapies for TB/HIV coinfection: a meta-analysis of randomized controlled trials.

AIDS Res Ther 2021 05 1;18(1):25. Epub 2021 May 1.

Department of Evidence-Based Medicine and Clinical Center, The First People's Hospital of Huaihua, University of South China, Huaihua, 418000, People's Republic of China.

Background: Integrase inhibitors (INIs)-based antiretroviral therapies (ART) are more recommended than efavirenz (EFV)-based ART for people living with HIV/AIDS (PLWHA). Yet, the advantage of integrase inhibitors in treating TB/HIV coinfection is uncertain. Therefore, the objective of this systematic review is to evaluate the effects and safety of INIs- versus EFV-based ART in TB/HIV coinfection, and demonstrate the feasibility of the regimens. Read More

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Determinants of gender disparities in scaling up the first 90 towards the UNAIDS 90-90-90 targets in South Africa: findings from the 2017 household-based national cross-sectional survey.

AIDS Res Ther 2021 04 28;18(1):24. Epub 2021 Apr 28.

Deputy CEO for Research, Human Sciences Research Council, Cape Town, South Africa.

Background: The first 90 of UNAIDS 90-90-90 targets to have 90% of the people living with HIV know their status is an important entry point to the HIV treatment cascade and care continuum, but evidence shows that there is a large gap between males and females in this regard. It is therefore important to understand barriers and facilitators of achieving the first 90 target. This study examined determinants of the first 90 target among females and males in order to inform strategies aimed at improving the HIV cascade in South Africa. Read More

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The prevalence of depression among adolescent with HIV/AIDS: a systematic review and meta-analysis.

AIDS Res Ther 2021 04 27;18(1):23. Epub 2021 Apr 27.

Departmemt of Psychiatry, Aksum University, Aksum, Ethiopia.

Background: Depression is particularly common among adolescents with HIV/AIDS and has been associated with disruption of the important developmental process, subsequently leading to a wide range of negative mental, physical and psychosocial consequences, as well as poor quality of life in those population groups. Nevertheless, to the best of our knowledge, there are no prior systematic reviews and meta-analytic studies that determined the prevalence of depression among adolescents with HIV/AIDS.

Method: We systematically searched PubMed, Scopus and Web of Science for relevant literature until May 2020. Read More

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Impact of strategic use of antiretroviral therapy intervention to the HIV continuum of care in 13 cities in Indonesia: an interrupted time series analysis.

AIDS Res Ther 2021 04 26;18(1):22. Epub 2021 Apr 26.

Health Sciences Building, College of Medicine and Public Health, Flinders University, Sturt Rd Bedford Park, Adelaide, SA, 5042, Australia.

Background: In 2013 the Indonesian government introduced the strategic use of antiretroviral therapy (SUFA) initiative of expanding access to HIV test and treatment, to help achieve the UNAIDS 90-90-90 targets. However, there has been no comprehensive evaluation of the impact of this intervention in Indonesia. We conducted an interrupted time series (ITS) analysis across 6-years to assess its immediate and medium-term impact. Read More

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HIV prevention at drug shops: awareness and attitudes among shop dispensers and young women about oral pre-exposure prophylaxis and the dapivirine ring in Shinyanga, Tanzania.

AIDS Res Ther 2021 04 26;18(1):21. Epub 2021 Apr 26.

School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA, 94704, USA.

Background: HIV risk remains high among adolescent girls and young women (AGYW, ages 15-24) in Tanzania. Many AGYW experience stigma and provider bias at health facilities, deterring their use of HIV prevention services. Privately-owned drug shops, ubiquitous in many communities, may be an effective and accessible channel to deliver HIV prevention products to AGYW, including oral pre-exposure prophylaxis (PrEP) and the dapivirine vaginal ring. Read More

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The expansion of a patient tracer programme to identify and return patients loss to follow up at a large HIV clinic in Trinidad.

AIDS Res Ther 2021 04 23;18(1):20. Epub 2021 Apr 23.

Medical Research Foundation of Trinidad and Tobago, 7 Queen's Park East, Port of Spain, Trinidad and Tobago.

Background: Patients who default from HIV care are usually poorly adherent to antiretroviral treatment which results in suboptimal viral suppression. The study assessed the outcomes of retention in care and viral suppression by expansion of an intervention using two patient tracers to track patients lost to follow up at a large HIV clinic in Trinidad.

Methods: Two Social Workers were trained as patient tracers and hired for 15 months (April 2017-June 2018) to call patients who were lost to follow up for 30 days or more during the period July 2016-May 2018 at the HIV clinic Medical Research Foundation of Trinidad and Tobago. Read More

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Predictors of virological failure among people living with HIV receiving first line antiretroviral treatment in Myanmar: retrospective cohort analysis.

AIDS Res Ther 2021 04 21;18(1):16. Epub 2021 Apr 21.

Disease Control Office, National AIDS Programme, Naypyidaw, Myanmar.

Background: Progress toward the global target for 95% virological suppression among those on antiretroviral treatment (ART) is still suboptimal. We describe the viral load (VL) cascade, the incidence of virological failure and associated risk factors among people living with HIV receiving first-line ART in an HIV cohort in Myanmar treated by the Médecins Sans Frontières in collaboration with the Ministry of Health and Sports Myanmar.

Methods: We conducted a retrospective cohort study, including adult patients with at least one HIV viral load test result and having received of at least 6 months' standard first-line ART. Read More

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Contribution of the classical polymerase chain reaction in the diagnosis of a HIV-1 infected patient in Benin: a case report.

AIDS Res Ther 2021 04 21;18(1):18. Epub 2021 Apr 21.

Laboratory of Cell Biology and Physiology, Department of Biochemistry and Cellular Biology, Faculty of Sciences and Technology (FAST), Institute of Applied Biomedical Sciences (ISBA), University of Abomey-Calavi, Calavi, 01 BP 918, Cotonou, Benin.

Background: First ambitious target by 2020 of UNAIDS is that 90% of people living with HIV know their HIV status. In people older than 18 months of age, serological confirmation test is recommended to confirm HIV infection.

Case Presentation: Here we report the case of a patient tested positive with HIV-1, ELISA, Murex Ag⁄Ab Combination assay (OD450 = 0. Read More

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Fecal carriage of extended spectrum beta-lactamase producing Enterobacteriaceae among HIV infected children at the University of Gondar Comprehensive Specialized Hospital Gondar, Ethiopia.

AIDS Res Ther 2021 04 21;18(1):19. Epub 2021 Apr 21.

Department of Medical Microbiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Human immunodeficiency virus (HIV) and extended spectrum beta lactamase (ESBL) producing Enterobacteriaceae infections are the major challenges in sub-Saharan Africa. Data on the carriage rate of ESBL producing Enterobacteriaceae among HIV infected children is lacking in Ethiopia. Hence this study was aimed to investigate fecal carriage of ESBL producing Enterobacteriaceae among HIV infected children at the University of Gondar comprehensive Specialized Hospital. Read More

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Predictors of failure on second-line antiretroviral therapy with protease inhibitor mutations in Uganda.

AIDS Res Ther 2021 04 21;18(1):17. Epub 2021 Apr 21.

Joint Clinical Research Centre, Kampala, Uganda.

Introduction: Failure on second-line antiretroviral therapy (ART) with protease inhibitor (PI) mutations (VF-M) is on the rise. However, there is a paucity of information on the factors associated with this observation in low-income countries. Knowledge of underlying factors is critical if we are to minimize the number of PLHIV switched to costly third-line ART. Read More

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Disclosure and health-related outcomes among children living with HIV and their caregivers.

AIDS Res Ther 2021 04 20;18(1):13. Epub 2021 Apr 20.

Department of Psychology, University of Ghana, Legon, Accra, Ghana.

Background: The prevalence of disclosure of status to children living with the Human Immunodeficiency Virus (HIV) is low in most sub-Saharan African countries, leading to poor compliance and adverse psychological outcomes in these children. This study examined the influence of disclosure on health outcomes in children living with HIV and their caregivers.

Methods: Using a cross-sectional design, 155 HIV-positive children between age 6-15 years and their caregivers were administered standardized questionnaires measuring adherence to medication, children's psychological well-being, caregiver burden, and caregivers' psychological health. Read More

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Prevalence and associated factors of HIV self-testing among men who have sex with men in Ningbo, China: a cross-sectional study.

AIDS Res Ther 2021 04 20;18(1):14. Epub 2021 Apr 20.

Zhejiang Provincial Institute of Dermatology, 61 Wuyuan Road, Deqing, 313200, Zhejiang, China.

Background: HIV testing and early linkage to care are critical for reducing the risk of HIV transmission. HIV self-testing (HIVST) is a useful tool for increasing HIV testing frequency.This study aimed to investigate HIVST rates among men who have sex with men (MSM), the characteristics of MSM who had HIVST, and factors associated with HIVST uptake among MSM in Ningbo, China. Read More

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Linkage to intensive adherence counselling among HIV-positive persons on ART with detectable viral load in Gomba district, rural Uganda.

AIDS Res Ther 2021 04 20;18(1):15. Epub 2021 Apr 20.

School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Antiretroviral therapy (ART) adherence is a primary determinant of sustained viral suppression, HIV transmission risk, disease progression and death. The World Health Organization recommends that adherence support interventions be provided to people on ART, but implementation is suboptimal. We evaluated linkage to intensive adherence counselling (IAC) for persons on ART with detectable viral load (VL). Read More

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New-onset focal seizure as a presenting feature of HIV infection: a case report and mini review to the challenge in resource-limited settings.

AIDS Res Ther 2021 04 15;18(1):12. Epub 2021 Apr 15.

Hayat Medical College, Addis Ababa, Ethiopia.

Background: The frequency of new-onset HIV-associated seizure in the HIV-infected patient is estimated to be between 2 and 11%. Identifying the underlying etiology of new-onset seizure will have a vital impact on the mortality and morbidity of patients living with HIV infection.

Case Presentation: We report a 34-year old newly diagnosed HIV+ male patient presented with abnormal body movement (ABM) involving his right hemibody associated with loss of consciousness lasting few minutes of two weeks duration. Read More

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The role of CD38 in HIV infection.

AIDS Res Ther 2021 04 5;18(1):11. Epub 2021 Apr 5.

Department of Transfusion, The Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, Sichuan, 646000, People's Republic of China.

The widely-expressed molecule CD38 is a single-stranded type II transmembrane glycoprotein that is mainly involved in regulating the differentiation and activation state of the cell. CD38 has broad and complex functions, including enzymatic activity, intercellular signal transduction, cell activation, cytokine production, receptor function and adhesion activity, and it plays an important role in the physiological and pathological processes of many diseases. Many studies have shown that CD38 is related to the occurrence and development of HIV infection, and CD38 may regulate its progression through different mechanisms. Read More

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Early retention among pregnant women on 'Option B + ' in urban and rural Zimbabwe.

AIDS Res Ther 2021 04 1;18(1):10. Epub 2021 Apr 1.

National AIDS Council, Harare, Zimbabwe.

Background: In 2013, the World Health Organisation (WHO) recommended Option B+ as a strategy to prevent mother-to-child transmission (PMTCT) of HIV. In option B+ , lifelong antiretroviral therapy (ART) is offered to all HIV positive pregnant and breastfeeding women to reduce MTCT rate to less than or equal to 5%. Its success depends on retaining women on ART during pregnancy, delivery and breast-feeding period. Read More

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Accelerating caregivers' HIV status disclosure to community-based lay social welfare volunteers in Tanzania.

AIDS Res Ther 2021 04 1;18(1). Epub 2021 Apr 1.

Pact, P.O. Box 6348, Dar es Salaam, Tanzania.

Background: HIV status disclosure facilitates access to HIV-related prevention and treatment services and increases opportunities for social support, HIV risk reduction with partners, and index testing for sexual partners or children. This study assessed the effect of a program model of community-based social welfare volunteers on HIV status disclosure among caregivers of orphans and vulnerable children (OVC).

Methods: This was a longitudinal study, which was based on OVC caregivers who were beneficiaries of the USAID Kizazi Kipya project in Tanzania. Read More

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The mediated effect of HIV risk perception in the relationship between peer education and HIV testing uptake among three key populations in China.

AIDS Res Ther 2021 03 25;18(1). Epub 2021 Mar 25.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan, Shandong, 250012, People's Republic of China.

Background: Peer education and HIV risk perception are related to HIV testing uptake among key populations. We aimed to examine the association between peer education, HIV risk perception, and HIV testing uptake, as well as to evaluate the mediated effect of HIV risk perception in the relationship between peer education and HIV testing uptake.

Methods: We conducted a cross-sectional survey among 1188 HIV-uninfected or unknown participants from populations of men who have sex with men (MSM), female sex workers (FSWs), and drug users (DUs) in seven cities of China. Read More

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Incidence and predictors of early loss to follow up among patients initiated on protease inhibitor-based second-line antiretroviral therapy in southwestern Uganda.

AIDS Res Ther 2021 03 20;18(1). Epub 2021 Mar 20.

Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.

Background: Good adherence to antiretroviral therapy (ART) and retention in care are essential for the effectiveness of an HIV care program. With the current increase in numbers of people living with HIV taking second-line ART in sub-Saharan Africa, there is a need to establish their treatment outcomes and the rate of loss to follow up. In this study, we determined the incidence and predictors of loss to follow up among patients taking second-line ART at an experienced HIV treatment center in southwestern Uganda. Read More

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Adherence predictor variables in AIDS patients: an empirical study using the data mining-based RFM model.

AIDS Res Ther 2021 01 28;18(1). Epub 2021 Jan 28.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.

Background: Highly active antiretroviral therapy (ART) is still the only effective method to stop the disease progression in acquired immunodeficiency syndrome (AIDS) patients. However, poor adherence to the therapy makes it ineffective. In this work, we construct an adherence prediction model of AIDS patients using the classical recency, frequency and monetary value (RFM) model in the data mining-based customer relationship management model to obtain adherence predictor variables. Read More

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January 2021

Multilevel model on longitudinal data analysis in determinants of CD4 cell count among antiretroviral therapy attendant of HIV infected adults follow up in Gondar Teaching Referral Hospital, Gonder, Ethiopia.

Authors:
Kindu Kebede

AIDS Res Ther 2021 01 15;18(1). Epub 2021 Jan 15.

Department of Statistics, College of Computing and Informatics, Haramaya University, Harar, Ethiopia.

Background: Human immunodeficiency virus attacked an immune cell and the CD4 cell which is responsible for the body's immune to infectious agents. Acquired immunodeficiency syndrome is one of the major public health problems in Sub-Saharan Africa including Ethiopia. The main objective of this study to identify the determinants of CD4 cell count among antiretroviral therapy attendants of infected adults follow up in Gonder teaching referral hospital, Gonder, Ethiopia implemented by SAS version 94. Read More

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January 2021