Conformation-dependent interactions between HIV-1 envelope glycoproteins and broadly neutralizing antibodies.
AIDS Res Hum Retroviruses 2018 Jun 15. Epub 2018 Jun 15.
University of Minnesota, Department of Medicine , Room 2-101 MRF , 689 23rd Av SE , Minneapolis, Minnesota, United States , 55455 ;
The human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) mediate virus entry and are the target of neutralizing antibodies. Binding of the metastable HIV-1 Env trimer to the CD4 receptor triggers structural rearrangements that mediate Env conformational transitions from a closed conformation to a more open state through an intermediate step. Recent studies have revealed new insights on the dynamics, regulation and molecular mechanisms of Env transitions along the entry pathway. Read More