269,832 results match your criteria AIDS London England[Journal]


No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Naïve HIV Patients.

Intervirology 2019 Apr 24:1-11. Epub 2019 Apr 24.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China,

Objectives: The epidemiological evidence is inconsistent about whether HIV-positive injection drug users (IDUs) are at higher risk of developing antiretroviral resistance than any other HIV-positive populations. This study aims to investigate and compare transmitted drug resistance (TDR) between IDUs and non-IDUs in Lingshan County, an HIV-hit region in Guangxi, China, where IDU and heterosexual transmission were the two dominant transmission routes and roughly equally contributed to the local HIV transmission.

Methods: A cross-sectional study was conducted among newly diagnosed and antiretroviral-treatment (ART)-naïve HIV-1 patients from Lingshan County. Read More

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https://www.karger.com/Article/FullText/499367
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http://dx.doi.org/10.1159/000499367DOI Listing
April 2019
5 Reads

Tuberculosis - United States, 2018.

Am J Transplant 2019 May;19(5):1582-1588

Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control, Atlanta, Georgia.

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http://dx.doi.org/10.1111/ajt.15384DOI Listing

Low rate of early vertical transmission of HIV supports the feasibility of effective implementation of the national PMTCT guidelines in routine practice of referral hospitals in Cameroon.

Paediatr Int Child Health 2019 Apr 24:1-8. Epub 2019 Apr 24.

l Assistance Publique des Hôpitaux de Paris, Pédiatrie Générale , Hôpital Robert Debré , Paris , France.

Background: Vertical (VT) transmission of HIV remains a public health concern in sub-Saharan Africa.

Objective: To investigate the VT rate and factors associated with transmission in routine practice in three referral hospitals in Cameroon.

Methods: All HIV-infected mothers who delivered in maternity wards or sought paediatric services during the first postnatal week from November 2007 to October 2010 were invited to participate in the ANRS-Pediacam cohort. Read More

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http://dx.doi.org/10.1080/20469047.2019.1585136DOI Listing

The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation.

APMIS 2019 Apr 24. Epub 2019 Apr 24.

Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, 2100 Kbh Ø, Copenhagen, Denmark.

Tingstedt JL, Hove-Skovsgaard M, Gaardbo J, Ullum H, Nielsen SD, Gelpi M. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation. Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non-AIDS-related morbidities, including cardiovascular diseases (CVD). Read More

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http://dx.doi.org/10.1111/apm.12956DOI Listing

Reaching 90-90-90: outcomes of a 15-year multi-country HIV workplace programme in sub-Saharan Africa.

Antivir Ther 2019 Apr 24. Epub 2019 Apr 24.

Department Global Health and Safety, Heineken International B.V., Amsterdam, the Netherlands.

Background: In 2001, an international beverage company implemented an HIV workplace program providing free antiretroviral treatment (ART) for employees and dependents in sub-Saharan Africa, at a time when ART, cost assessments of ART programs and related public funding was hardly available. This study describes the outcomes of this program with respect to achieving the UNAIDS 90-90-90 targets in 5 African countries and analyzes trends over the past 15 years.

Methods: Anonymous human resource data were analyzed in three cohorts of participants (those enrolling in 2001-2005, 2006-2010, and 2011-2015). Read More

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http://dx.doi.org/10.3851/IMP3311DOI Listing

Effectiveness of the Bobath concept in the treatment of stroke: a systematic review.

Disabil Rehabil 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Department of Radiology, Rehabilitation and Physiotherapy, Faculty of Nursing , Physiotherapy and Podiatry, Complutense University of Madrid , Madrid , Spain.

Purpose: To evaluate the effectiveness of the Bobath concept in sensorimotor rehabilitation after stroke.

Materials And Methods: A systematic literature review was conducted on the Bobath concept from the first publication available to January 2018, consulting PUBMED, CENTRAL, CINAHL and PEDro databases. Fifteen clinical trials were selected in two consecutive screenings. Read More

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http://dx.doi.org/10.1080/09638288.2019.1590865DOI Listing

Primary health care: an opportunity for early identification of people living with undiagnosed HIV infection.

HIV Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Infectious Diseases, Odense University Hospital, Odense C, Denmark.

Objectives: We aimed to determine the fraction of HIV-diagnosed individuals who had primary health care (PHC) contacts 3 years prior to HIV diagnosis and whether the risk of HIV diagnosis and degree of immunodeficiency were associated with the frequency of visits or procedures performed.

Methods: We used data from national registries to conduct a population-based nested case-control study. Cases were individuals diagnosed with HIV infection in Denmark from 1998 to 2016. Read More

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http://dx.doi.org/10.1111/hiv.12735DOI Listing

HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein.

J Neurovirol 2019 Apr 23. Epub 2019 Apr 23.

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10; Room 7C-103, 10 Center Drive, Bethesda, MD, 20892, USA.

In patients infected with the human immunodeficiency virus (HIV), the HIV-Tat protein may be continually produced despite adequate antiretroviral therapy. As the HIV-infected population is aging, it is becoming increasingly important to understand how HIV-Tat may interact with proteins such as amyloid β and Tau which accumulate in the aging brain and eventually result in Alzheimer's disease. In this review, we examine the in vivo data from HIV-infected patients and animal models and the in vitro experiments that show how protein complexes between HIV-Tat and amyloid β occur through novel protein-protein interactions and how HIV-Tat may influence the pathways for amyloid β production, degradation, phagocytosis, and transport. Read More

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http://dx.doi.org/10.1007/s13365-019-00736-zDOI Listing

Physical Activity and HIV: Effects on Fitness Status, Metabolism, Inflammation and Immune-Activation.

AIDS Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, 00161, Rome, Italy.

Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status, metabolism, inflammation and immune-activation in people living with HIV, an interim analysis of the results of the clinical trial PRIMO (NCT03392805) was performed. Patients enrolled were divided in 2 groups on the basis of self-prescribed physical activity: a physically active group (self-prescribed physical activity) and a sedentary group. Read More

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http://dx.doi.org/10.1007/s10461-019-02510-yDOI Listing

Effect of a Community-Level HIV Prevention Intervention on Psychosocial Determinants of HIV Risk Behaviors among Young Black Men Who Have Sex with Men (YBMSM).

AIDS Behav 2019 Apr 23. Epub 2019 Apr 23.

University of California, San Francisco, San Francisco, CA, USA.

In contrast to intervention studies that assess psychosocial factors only as mediators or moderators of HIV risk, the present study assessed the effects of an Mpowerment-based community-level intervention on psychosocial determinants (e.g., depressive symptoms, sexual stigma) of HIV risk behavior among young black MSM. Read More

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http://dx.doi.org/10.1007/s10461-019-02499-4DOI Listing

Growth Trajectories of Peer Norms, Self-efficacy and Condom Use Behavior Among Sexually Active Chinese Men Who Have Sex with Men: Latent Class Analysis and Growth Mixture Modeling.

AIDS Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology, School of Public Health, Shandong University, 44 West Wenhua Road, Jinan, 250012, Shandong, China.

Data from a randomized controlled trial in 2015 were used to estimate the growth trajectories of peer norms, self-efficacy, and condom use behavior, and to identify associated sociodemographic and behavioral factors among a sample of 804 Chinese men who have sex with men (MSM). Latent class analysis and growth mixture modeling were conducted using Mplus. Two growth trajectories were estimated for each outcome variable with good model fit. Read More

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http://dx.doi.org/10.1007/s10461-019-02515-7DOI Listing

Dentist's Delay or Dexterity to Diagnose the Deadly: A Clinico-radiological Series of Oral Malignancies Exhibiting Varied Presentations in the Tamil Nadu Rural Belt.

Cureus 2019 Feb 11;11(2):e4051. Epub 2019 Feb 11.

Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital, Chennai, IND.

Oral cancer is the sixth most common malignancy globally with a wide geographic variation. India is the second largest consumer and third largest producer of tobacco in the world. One-third of the global burden of oral cancer is predominantly attributed to high prevalence of tobacco consumption. Read More

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http://dx.doi.org/10.7759/cureus.4051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464439PMC
February 2019

Factors influencing quality of life (QOL) amongst elderly caregivers of people living with HIV/AIDS in Phayao province, Thailand: a cross-sectional study.

F1000Res 2019 9;8:39. Epub 2019 Jan 9.

Department of Public Health, Health Services Academy, Islamabad, 44000, Pakistan.

There are many impacts on quality of life among elderly people living with HIV patients. This study aimed to assess factors influencing quality of life among elderly people living with HIV/AIDS in a northern province of Thailand. This cross-sectional study was conducted in Phayao province, Thailand. Read More

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http://dx.doi.org/10.12688/f1000research.16892.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456834PMC
January 2019

Recommendations for assessing motor performance in individuals with dementia: suggestions of an expert panel - a qualitative approach.

Eur Rev Aging Phys Act 2019 13;16. Epub 2019 Apr 13.

1Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Engler-Bunte-Ring 15, 76131 Karlsruhe, Germany.

Background: Recommendations for assessing motor performance in individuals with dementia (IWD) are rare, and most existing assessment tools previously applied in IWD were initially developed for healthy older adults. However, IWD and their healthy counterparts differ in motor and cognitive capabilities, which needs to be considered when designing studies for this population. This article aims to give recommendations for motor assessments for IWD and to promote standardisation based on a structured discussion of identified assessment tools used in previous trials. Read More

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http://dx.doi.org/10.1186/s11556-019-0212-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463628PMC

A Systematic Review and Meta-Analysis of Epidemiology of Risky Sexual Behaviors in College and University Students in Ethiopia, 2018.

J Environ Public Health 2019 20;2019:4852130. Epub 2019 Mar 20.

Department of Internal Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: Risk of sexual ill-health occurs with the onset of unsafe sexual activity, mostly among the adolescents, and continues as long as the risky activities are engaged in. Globally, and in Africa, adolescent AIDS-related mortality among adolescents has been increasing. Therefore, a systematic review and meta-analysis of epidemiology of risky sexual behaviors in college and university students in Ethiopia is mandatory. Read More

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http://dx.doi.org/10.1155/2019/4852130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446110PMC

K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation.

Sci Rep 2019 Apr 23;9(1):6416. Epub 2019 Apr 23.

Division of Morphological Pathology, Department of Basic Laboratory Sciences, School of Health Sciences, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.

Kaposi's sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi's sarcoma (KS) and classic KS, but their clinical presentations are different, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosine-based activation motif (ITAM). Since we found the sequence variations in the K1 gene of KSHV isolated from AIDS-related KS and classic KS, we hypothesized that the transformation activity of the K1 gene contributes to the different clinical presentations. Read More

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http://dx.doi.org/10.1038/s41598-019-42763-0DOI Listing

Pool-seq driven proteogenomic database for Group G Streptococcus.

J Proteomics 2019 Apr 20. Epub 2019 Apr 20.

Research Programs Unit, Immunobiology, Univ. of Helsinki, Helsinki, Finland.

Proteogenomic databases use genomic and transcriptomic information for improved identification of peptides and proteins from mass spectrometry analyses. One application of such databases is in the discovery of variants/mutations. In this study, we created a proteogenomic database that contained sequences with variants derived from Pooled sequencing experiments (137 Group G Streptococcus strains sequenced in 3 pools) and used tandem mass spectrometry (MS/MS) to analyse eight protein samples from randomly selected strains sequenced in the pools. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.015DOI Listing
April 2019
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Linguatula serrata, a food-borne zoonotic parasite, in livestock in Bangladesh: Some pathologic and epidemiologic aspects.

Vet Parasitol Reg Stud Reports 2018 Aug 7;13:135-140. Epub 2018 Jun 7.

Department of Parasitology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

Food-borne parasitic zoonoses are major threats to human health and only next to the 'big three' such as AIDS, tuberculosis and malaria. Linguatula serrata is a food-borne zoonotic pentastomid that affects a wide range of animals including humans. Dogs and other carnivores are the final hosts while most herbivores, including domestic ruminants serve as intermediate hosts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24059390173027
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http://dx.doi.org/10.1016/j.vprsr.2018.06.001DOI Listing
August 2018
1 Read

Determinants of Reading Performance in Eyes with Foveal-Sparing Geographic Atrophy.

Ophthalmol Retina 2019 Mar 22;3(3):201-210. Epub 2018 Nov 22.

Department of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address:

Purpose: To identify anatomic determinants of reading performance in eyes with foveal-sparing geographic atrophy (GA).

Design: Prospectively recruited, cross-sectional study, SIGHT (clinicaltrials.gov identifier, NCT02332343). Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.005DOI Listing

Sociodemographic inequities in cervical cancer screening, treatment and care amongst women aged at least 25 years: evidence from surveys in Harare, Zimbabwe.

BMC Public Health 2019 Apr 24;19(1):428. Epub 2019 Apr 24.

Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Background: Cervical cancer is the most commonly diagnosed cancer among women in Zimbabwe; however; access to screening and treatment services remain challenged. The objective of this study was to investigate socio-demographic inequities in cervical cancer screening and utilization of treatment among women in Harare, Zimbabwe.

Methods: Two cross sectional surveys were conducted in Harare with a total sample of 277 women aged at least 25 years. Read More

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http://dx.doi.org/10.1186/s12889-019-6749-6DOI Listing

HIV leadership programming attendance is associated with PrEP and PEP awareness among young, gay, bisexual, and other men who have sex with men in Vancouver, Canada.

BMC Public Health 2019 Apr 24;19(1):429. Epub 2019 Apr 24.

British Columbia Centre for Excellence in HIV/AIDS, 608-1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada.

Background: Young gay, bisexual, and other men who have sex with men (YGBM) may have reduced engagement and knowledge of HIV care and biomedical HIV prevention strategies, such as pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), and Treatment as Prevention (TasP), compared with adult GBM. We sought to understand differences in HIV prevention awareness, health care access, and service utilization between youth (16-29 years) and adult (≥30 year) GBM, as well as factors associated with attendance in HIV leadership programming among YGBM living in the publicly funded PrEP setting of Vancouver, Canada.

Methods: Sexually-active GBM were recruited using respondent-driven sampling (RDS) from February 2012 to February 2015. Read More

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http://dx.doi.org/10.1186/s12889-019-6744-yDOI Listing

Impact of physical exercises on immune function, bone mineral density, and quality of life in people living with HIV/AIDS: a systematic review with meta-analysis.

BMC Infect Dis 2019 Apr 24;19(1):340. Epub 2019 Apr 24.

Fakultaat III, Hochschhule Hannover University of Applied Sciences & Arts, Expo Plaza 12, 30539, Hannover, Germany.

Background: Compromised immune function, associated with human immune deficiency virus(HIV) infection, is improved by antiretroviral therapy(ART) which also decreases bone mineral density(BMD), and possibly the quality of life(QoL). However, physical(aerobic/resistance) exercises, were reported to induce reverse effects in uninfected individuals and were appraised in the literature for evidence of similar benefits in people living with HIV/AIDS(PLWHA). The main study objective was to evaluate the impact of physical (aerobic and resistance) exercises on CD count, BMD and QoL in PLWHA. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3916-4DOI Listing
April 2019
1 Read

'Sometimes it is not about men': Gendered and generational discourses of caregiving HIV transmission in a rural South African setting.

Glob Public Health 2019 Apr 23:1-13. Epub 2019 Apr 23.

b American University , Washington , DC , USA.

In this paper, we examine a prominent interpretation of HIV risk in a rural South African setting experiencing a severe HIV epidemic well into older ages: the discourse of caregiving HIV transmission. By caregiving transmission, we refer to HIV infection resulting from caring for family members who are living with HIV and may be sick with AIDS-related illnesses. We draw on individual life history and community focus group interviews with men and women aged 40-80+, as well as interviews with health workers providing HIV counselling and testing services at local health facilities in their communities. Read More

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http://dx.doi.org/10.1080/17441692.2019.1606265DOI Listing

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor.

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Rooms 10307, 10309, and 10315, 245 North 15th Street, Philadelphia, PA 19102, USA.

Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here we demonstrate unique and differential effects of previously published antiviral compounds on the gross structure of the HIV-1 Env complex, with an azabicyclohexane scaffolded inhibitor having a positive effect on glycoprotein thermostability. Read More

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http://dx.doi.org/10.3390/molecules24081581DOI Listing

Design, Synthesis, Molecular Modeling, ADME Studies and Anti-HIV-1 Assay of New Diazocoumarin Derivatives.

Iran J Pharm Res 2018 ;17(Suppl2):65-77

Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Some new diazo incorporated coumarin compounds were designed and synthesized to evaluate their anti-HIV activity. Overall, compounds were active against HIV at 100 μM. Additionally, no cytotoxic effect was observed at this concentration. Read More

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January 2018

Sexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples.

PLoS One 2019 23;14(4):e0215001. Epub 2019 Apr 23.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

The anogenital prevalence of sexually transmitted infections (STIs) and the use of cervico-vaginal self-collected vs. clinician-collected samples were evaluated for the diagnosis of human immunodeficiency virus (HIV)-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil. We recruited 153 women for a cross-sectional study (112 HIV-uninfected and 41 HIV-infected) who sought health services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215001PLOS

The language and communication attributes of graphic symbol communication aids - a systematic review and narrative synthesis.

Disabil Rehabil Assist Technol 2019 Apr 23:1-11. Epub 2019 Apr 23.

a Faculty of Health, Psychology and Social Care , Manchester Metropolitan University , Manchester , UK.

Background: Symbol communication aids are used by children with little or no intelligible speech as an Augmentative and Alternative Communication strategy. Graphic symbols are used to help support understanding of language and used in symbol communication aids to support expressive communication. The decision making related to the selection of a symbol communication aid for a child is poorly understood and little is known about what language and communication attributes are considered in this selection. Read More

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http://dx.doi.org/10.1080/17483107.2019.1604828DOI Listing

Tackling protein-energy under-nutrition among resource-limited people living with HIV/AIDS in Malawi using soybean-enriched maize-based stiff porridge (nsima): A pilot study.

Nutr Diet 2019 Apr 22. Epub 2019 Apr 22.

Food Technology and Nutrition Group, Lilongwe University of Agriculture and Natural Resources (LUANAR), Lilongwe, Malawi.

Aim: The Ministry of Health in Malawi has scaled-up antiretroviral therapy (ART) for HIV infection. However, the majority of Malawians heavily depend on maize-based stiff porridge (nsima), a protein-deficient staple, a practice that exacerbates wasting and ultimately compromises the success of ART programming. This pilot study was conducted to evaluate the efficacy of utilising soybean-enriched nsima as a strategy for managing HIV-related wasting among resource-poor people. Read More

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http://dx.doi.org/10.1111/1747-0080.12539DOI Listing

Correction to: Scaling-up PrEP Delivery in Sub-Saharan Africa: What Can We Learn from the Scale-up of ART?

Curr HIV/AIDS Rep 2019 Apr 22. Epub 2019 Apr 22.

Department of Global Health, University of Washington, Seattle, WA, USA.

The article "Scaling-up PrEP Delivery in Sub-Saharan Africa: What Can We Learn from the Scale-up of ART?", written by Gabrielle O'Malley, Gena Barnabee and Kenneth Mugwanya, was originally published electronically on the publisher's internet portal. Read More

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http://dx.doi.org/10.1007/s11904-019-00443-8DOI Listing

Ethics and Bias in Clinical Trial Enrollment in Stroke.

Curr Cardiol Rep 2019 Apr 22;21(6):49. Epub 2019 Apr 22.

Stroke Center, University of Utah, 175 N Medical Center Drive, Third Floor, Salt Lake City, UT, 84132, USA.

Purpose Of Review: To familiarize the reader with ethical concerns and potential scientific bias in management and conduction of clinical stroke trials.

Recent Findings: The goal of clinical trials in stroke is to find effective interventions for stroke prevention, acute treatment, and rehabilitation and recovery. Acute trials must be designed in the context of the time-sensitivity of revascularization therapies. Read More

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http://link.springer.com/10.1007/s11886-019-1139-3
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http://dx.doi.org/10.1007/s11886-019-1139-3DOI Listing
April 2019
1 Read

Reduced Elective Operation Rates and High Patient Satisfaction After the Implementation of Decision Aids in Patients with Gallstones or an Inguinal Hernia.

World J Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Background: For both gallbladder removal and inguinal hernia repair, it is important to include patients' perspective in the decision-making process, as watchful waiting is an accepted alternative in selected patients. The aim of this study was to evaluate operation rates before and after implementation of decision aids (DAs) and to assess patient compliance with the use of DAs.

Methods: A single-centered retrospective study was performed, including all patients ≥18 years referred to the surgical outpatient clinic with symptomatic gallstones or an inguinal hernia between January 2014 and December 2017. Read More

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http://dx.doi.org/10.1007/s00268-019-05007-wDOI Listing

Economic Potential for Distributed Manufacturing of Adaptive Aids for Arthritis Patients in the U.S.

Geriatrics (Basel) 2018 Dec 6;3(4). Epub 2018 Dec 6.

Department of Materials Science & Engineering, Michigan Technological University, Houghton, MI 49931, USA.

By 2040, more than a quarter of the U.S. population will have diagnosed arthritic conditions. Read More

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http://dx.doi.org/10.3390/geriatrics3040089DOI Listing
December 2018

CD4+ T cell regulation of antibodies cross-reactive with fungal cell wall associated carbohydrates after infection.

Infect Immun 2019 Apr 22. Epub 2019 Apr 22.

Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, Louisiana, 70112.

pneumonia is a life-threatening opportunistic fungal infection observed in individuals with severe immunodeficiencies, such as AIDS. Molecules with the ability to bind β-glucan and signal at Fc-γ receptors enhance defense against f. sp. Read More

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http://dx.doi.org/10.1128/IAI.00158-19DOI Listing

Evaluation of facility and community-based active household tuberculosis contact investigation in Ethiopia: a cross-sectional study.

BMC Health Serv Res 2019 Apr 22;19(1):234. Epub 2019 Apr 22.

International Training and Education Center for Health (I-TECH Ethiopia), Addis Ababa, Ethiopia.

Background: No established strategy for household tuberculosis (TB) contact investigation (HTCI) exists in Ethiopia. We implemented integrated, active HTCI model into two hospitals and surrounding community health services to determine yield of active HTCI of all forms of TB and explore factors associated with active TB diagnosis in household contacts (HHCs).

Methods: Case managers obtained HHC information from index cases at TB/DOTS clinic and liaised with health extension workers (HEWs) who screened HHCs for TB at household and referred contacts under five and presumptive cases for diagnostic investigation. Read More

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http://dx.doi.org/10.1186/s12913-019-4074-5DOI Listing

Associations Between Physical Health Limitations and Community Participation Among People With and Without Serious Mental Illnesses.

Psychiatr Serv 2019 Apr 23:appips201800407. Epub 2019 Apr 23.

Department of Psychology, Portland State University, Portland, Oregon (Townley, Terry); Department of Rehabilitation Sciences (Brusilovskiy, Snethen) and Department of Social and Behavioral Sciences (Salzer), Temple University, Philadelphia.

Objective: Research has suggested that individuals with serious mental illnesses are not as physically healthy as the general population and are more likely to experience physical illnesses such as diabetes, obesity, and cardiovascular and respiratory diseases. Less is known about how physical health may be related to community participation among individuals with serious mental illnesses, although research with adults in the general population has suggested strong negative associations between health impairments and engagement in a variety of activity domains.

Methods: In this study, the authors drew from two national data sets to examine the relationship between physical health impairments and community participation among 300 participants with serious mental illnesses and 300 participants without serious mental illnesses. Read More

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http://dx.doi.org/10.1176/appi.ps.201800407DOI Listing

A syndemic of psychosocial and mental health problems in Liberia: Examining the link to transactional sex among young pregnant women.

Glob Public Health 2019 Apr 22:1-12. Epub 2019 Apr 22.

c Department of Health Promotion and Behavior , University of Georgia , Athens , GA , USA.

Transactional sex may be a driver of the rising HIV epidemic in Liberia, especially among young women. The goal of this study was to explore the independent and additive effects of psychosocial conditions on engagement in transactional sex among 191 pregnant women in Monrovia, Liberia. Between March and August 2016, women receiving prenatal services completed a cross-sectional structured questionnaire. Read More

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http://dx.doi.org/10.1080/17441692.2019.1607523DOI Listing

Racial/ethnic differences in perceived risks and benefits of quitting smoking in a sample of African American and Hispanic adults living with HIV/AIDS: A preliminary study.

J Ethn Subst Abuse 2019 Apr 22:1-16. Epub 2019 Apr 22.

a Yeshiva University , Bronx , New York.

Persons living with HIV/AIDS (PLWH) report very high prevalences of cigarette smoking, and there are racial/ethnic disparities in smoking consequences and quit outcomes. In this exploratory pilot study, we examined racial/ethnic differences in perceived risks and benefits of quitting cigarette smoking among 97 adult PLWH in the Bronx, New York (Hispanic, 53.6%; African American, 46. Read More

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http://dx.doi.org/10.1080/15332640.2019.1598906DOI Listing

The Contribution of Host Cells to Immunity: An Update.

Pathogens 2019 Apr 19;8(2). Epub 2019 Apr 19.

AFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts as obligate intra-pulmonary pathogens. In humans, is the causative organism of Pneumocystis pneumonia (PCP) in immunocompromised individuals, a serious illness frequently leading to life-threatening respiratory failure. Read More

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http://dx.doi.org/10.3390/pathogens8020052DOI Listing

Effect of Microbiological Growth Components for Bacteria-Based Self-Healing on the Properties of Cement Mortar.

Materials (Basel) 2019 Apr 20;12(8). Epub 2019 Apr 20.

Department of Civil Engineering, University of Tripoli, Tripoli 13110, Libya.

Previous studies of bacteria-based self-healing concrete have shown that it is necessary to encapsulate and separate the self-healing ingredients (bacteria, nutrients, and precursors) in the concrete so that when a crack forms, capsules rupture, which allows the self-healing ingredients to come together and precipitate calcite into the crack. Because of the shearing action in the concrete mixer, there is a chance that these capsules, or other carriers, may rupture and release the self-healing ingredients. This would affect the efficiency of self-healing, but may detrimentally affect the concrete's properties. Read More

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http://dx.doi.org/10.3390/ma12081303DOI Listing

A Pilot Metabolomics Study of Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Int J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Mycobacterial Research Laboratories, Colorado State University, Fort Collins, CO, USA; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS.

Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.015DOI Listing

A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
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http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
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Prevalence, intensity and associated risk factors of soil transmitted helminth infections: A comparison between Negritos (indigenous) in inland jungle and those in resettlement at town peripheries.

PLoS Negl Trop Dis 2019 Apr 22;13(4):e0007331. Epub 2019 Apr 22.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: Formerly known as the Malaysian hunter gatherers, the Negrito Orang Asli (OA) were heavily dependent on the forest for sustenance and early studies indicated high prevalence of intestinal parasitism. Initiation of a redevelopment program in the 1970s aimed to demarginalize the OA was expected to reduce soil transmitted helminth (STH) infections. Gradually, the OA were relocated to new resettlement areas at the peripheries. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007331DOI Listing

Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs utilizing therapeutic drug monitoring data in children living with HIV.

Ther Drug Monit 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud university medical centre, Nijmegen, The Netherlands.

Introduction: This review summarises the current dosing recommendations for antiretroviral drugs (ARVs) in the international pediatric guidelines of the World Health Organisation (WHO), US Department of Health and Human Services (DHHS), and Paediatric European Network for Treatment of AIDS (PENTA) and evaluates the research that informed these approaches. We further explore the role of data generated through therapeutic drug monitoring (TDM) in optimizing the dosing of ARVs in children.

Methods: A PubMed search was conducted for literature on ARV dosing published in English. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000637DOI Listing

Damage control orthopedics applied in an 8-year-old child with life-threatening multiple injuries: A CARE-compliant case report.

Medicine (Baltimore) 2019 Apr;98(16):e15294

University Children's Hospital Basel (UKBB), Department of Pediatric Surgery, 4056 Basel.

Rationale: Damage control is a staged surgical approach to manage polytraumatized patients. The damage control approach comprises three steps. First, bleeding is controlled and fractures are stabilized temporarily; second, vital parameters are stabilized and the child is rewarmed in the intensive care unit; and third, the child is reoperated for definitive repair of injuries. Read More

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http://Insights.ovid.com/crossref?an=00005792-201904190-0005
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http://dx.doi.org/10.1097/MD.0000000000015294DOI Listing
April 2019
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The role of quantitative sensory testing in the prediction of chronic pain.

Pain 2019 May;160 Suppl 1:S66-S69

Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany.

Quantitative sensory testing (QST) is a formal variant of a time-honoured clinical examination technique in neurology, the sensory examination. Prototypical QST profiles have been found in human surrogate models of peripheral sensitization, central sensitization, and deafferentation. Probabilistic sorting of individual patients to any combination of these profiles has been developed, and there is emerging evidence for the predictive value of such sensory profiles for treatment efficacy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001544DOI Listing

Serological Markers for Syphilis Among Persons Presenting with Syndromes Associated with Sexually Transmitted Infections Results from the Zimbabwe STI Etiology Study.

Sex Transm Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington School of Medicine, Seattle, WA, USA.

Background: Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001006DOI Listing

PrEP-RN: Clinical Considerations and Protocols for Nurse-Led PrEP.

J Assoc Nurses AIDS Care 2019 Apr 9. Epub 2019 Apr 9.

HIV pre-exposure prophylaxis (PrEP) is an increasingly important part of the HIV prevention armamentarium. Issues with PrEP, however, include access. We propose that one way to surmount this issue would be to have nurses provide PrEP. Read More

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http://dx.doi.org/10.1097/JNC.0000000000000075DOI Listing

Altered neuropsychological performance and reduced brain volumetrics in people living with HIV on integrase strand transfer inhibitors.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Washington University in St Louis, St Louis, USA.

Objectives: Neuropsychiatric symptoms have been reported in people living with HIV (PLWH) on integrase strand transfer inhibitors (INSTIs) in post marketing analysis. Limited data exists regarding brain integrity (function and structure) in PLWH prescribed INSTIs compared to other HIV treatment regimens.

Design: A cross-sectional analysis of PLWH on combined antiretroviral therapy (cART) aged >18 years at a single institution. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002236DOI Listing
April 2019
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