13,875 results match your criteria AIDS[Journal]


Disproportionate burden of COVID-19 among racial minorities and those in congregate settings among a large cohort of people with HIV.

AIDS 2020 Jun 25. Epub 2020 Jun 25.

Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.

Background: Many people living with HIV (PLWH) have comorbidities which are risk factors for severe COVID-19 or have exposures that may lead to acquisition of SARS-CoV-2. There are few studies, however, on the demographics, comorbidities, clinical presentation or outcomes of COVID-19 in people with HIV.

Objective: To evaluate risk factors, clinical manifestations and outcomes in a large cohort of PLWH with COVID-19. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002607DOI Listing

Monocyte and CD4+ T-cell antiviral and innate responses associated with HIV-1 inflammation and cognitive impairment.

AIDS 2020 Jul;34(9):1289-1301

aU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring bHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda cThe EMMES Corporation, Rockville, Maryland dMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA eFaculty of Medicine, Phramongkutklao Hospital fSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Objective: Mechanisms underlying immune activation and HIV-associated neurocognitive disorders (HAND) in untreated chronic infection remain unclear. The objective of this study was to identify phenotypic and transcriptional changes in blood monocytes and CD4 T cells in HIV-1-infected and uninfected individuals and elucidate processes associated with neurocognitive impairment.

Design: A group of chronically HIV-1-infected Thai individuals (n = 19) were selected for comparison with healthy donor controls (n = 10). Read More

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http://dx.doi.org/10.1097/QAD.0000000000002537DOI Listing

Cases of coronavirus disease-2019 in HIV-infected transgender women.

AIDS 2020 Jul;34(9):1435-1436

Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo.

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http://dx.doi.org/10.1097/QAD.0000000000002573DOI Listing

Efficacy of nivolumab in HIV patient with melanoma brain metastases.

AIDS 2020 Jul;34(9):1433-1435

Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit 'Daniele Innocenzi', Sapienza University of Rome, Polo Pontino.

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http://dx.doi.org/10.1097/QAD.0000000000002554DOI Listing

Low HIV incidence among women following sexually transmitted infection does not support national pre-exposure prophylaxis recommendations.

AIDS 2020 Jul;34(9):1429-1431

Public Health-Seattle & King County HIV/STD Program.

: Current United States guidelines recommend that clinicians offer HIV pre-exposure prophylaxis (PrEP) to women with gonorrhea or syphilis. We estimated HIV incidence among women following a syphilis, gonorrhea, or chlamydia diagnosis among women in King County, WA using surveillance data from 2008 to 2018. Among women with diagnosed with gonorrhea and among women diagnosed with chlamydia the estimated HIV incidence rates were 0. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002561DOI Listing

Orofacial outcomes in adolescents with perinatally infected HIV in antiretroviral therapy.

AIDS 2020 Jul;34(9):1417-1423

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal, de Minas Gerais (UFMG), Belo Horizonte-MG.

Objective: To assess the frequency of orofacial outcomes in adolescents with perinatally infected HIV in treatment with antiretroviral therapy (ART).

Design: A Brazilian institution-based retrospective study analyzing medical charts and medication dispensing data.

Methods: Medical records of 137 adolescents were reviewed. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002569DOI Listing

Direct maternal deaths attributable to HIV in the era of antiretroviral therapy: evidence from three population-based HIV cohorts with verbal autopsy.

AIDS 2020 Jul;34(9):1397-1405

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Objective: To assess whether HIV is associated with an increased risk of mortality from direct maternal complications.

Design: Population-based cohort study using data from three demographic surveillance sites in Eastern and Southern Africa.

Methods: We use verbal autopsy data, with cause of death assigned using the InSilicoVA algorithm, to describe the association between HIV and direct maternal deaths amongst women aged 20-49 years. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002552DOI Listing

Longitudinal patterns of illicit drug use, antiretroviral therapy exposure and plasma HIV-1 RNA viral load among HIV-positive people who use illicit drugs.

AIDS 2020 Jul;34(9):1389-1396

British Columbia Centre on Substance Use.

Objectives: HIV-positive people who use illicit drugs (PWUD) experience elevated rates of HIV-associated morbidity and mortality compared with members of other key affected populations. Although suboptimal levels of access and adherence to antiretroviral therapy (ART) are common among HIV-positive PWUD, there is a need for studies investigating the possible biological impacts of noninjection illicit drug use among people living with HIV in real-world settings.

Methods: We accessed data from the ACCESS study, an ongoing prospective cohort of illicit drug users with systematic HIV viral load monitoring in a setting with universal care and ART dispensation records. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002551DOI Listing

Malaria in HIV-infected patients in a nonendemic setting.

AIDS 2020 Jul;34(9):1359-1365

Infectious Diseases Department, Centre Hospitalier Universitaire (CHU) Saint-Pierre - Université Libre de Bruxelles (ULB).

Background: The impact of HIV infection on malaria is unclear in nonendemic areas. In endemic territories, HIV has been reported to be a risk factor for higher morbidity. Nowadays, as HIV-infected patients travel more, it is important to assess the impact of HIV at the individual level on imported malaria. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002568DOI Listing

HIV-exposed uninfected infant morbidity and mortality within a nationally representative prospective cohort of mother-infant pairs in Zimbabwe.

AIDS 2020 Jul;34(9):1339-1346

Division of Global HIV and TB, Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Objective: To examine morbidity and mortality risk among HIV-exposed uninfected (HEU) infants.

Design: Secondary data analysis of HEU infants in a prospective cohort study of mother-infant pairs.

Methods: Infants were recruited from immunization clinics (n = 151) in Zimbabwe from February to August 2013, enrolled at 4-12 weeks age, and followed every 3 months until incident HIV-infection, death, or 18-month follow-up. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002567DOI Listing
July 2020
5.554 Impact Factor

An HIV-1 Nef genotype that diminishes immune control mediated by protective human leucocyte antigen alleles.

AIDS 2020 Jul;34(9):1325-1330

Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.

Objectives: Certain human leucocyte antigen (HLA)-B alleles (protective alleles) associate with durable immune control of HIV-1, but with substantial heterogeneity in the level of control. It remains elusive whether viral factors including Nef-mediated immune evasion function diminish protective allele effect on viral control.

Design: The naturally occurring non-Ser variant at position 9 of HIV-1 subtype C Nef has recently exhibited an association with enhanced HLA-B downregulation function and decreased susceptibility to recognition by CD8 T cells. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002559DOI Listing

Managing amphetamine use is critical to achieving HIV control.

AIDS 2020 Jun 16. Epub 2020 Jun 16.

David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000002611DOI Listing

Oral pre-exposure prophylaxis (PrEP) continuation, measurement, and reporting: a systematic review and meta-analysis.

AIDS 2020 Jun 17. Epub 2020 Jun 17.

London School of Hygiene and Tropical Medicine, London, England.

Objective: To appropriately plan for rollout and monitor impact of oral pre-exposure prophylaxis (PrEP) it is important to understand PrEP continuation and come to a consensus on how best to measure PrEP continuation. This study reviews data on PrEP continuation to document how it is reported, and to compare continuation over time and across populations.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002598DOI Listing

First-line HIV treatment outcomes following the introduction of integrase inhibitors in UK guidelines: a cohort study.

AIDS 2020 Jun 8. Epub 2020 Jun 8.

Institute for Global Health, University College London, UK.

Objective: To investigate the characteristics and outcomes of people who initiated different antiretroviral therapy (ART) regimens during the era of integrase strand transfer inhibitors (INSTIs).

Design: UK-based observational cohort study.

Methods: UK Collaborative HIV Cohort study participants were included if they had started ART between 1 January 2012 and 30 June 2017. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002603DOI Listing

Potential impact of COVID-19 in people living with HIV: experience from previous 21st century coronaviruses epidemics.

Authors:
Nicolas Dauby

AIDS 2020 07;34(8):1255-1256

Department of Infectious Diseases, Centre Hospitalier Universitaire (CHU) Saint-Pierre.

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http://dx.doi.org/10.1097/QAD.0000000000002555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309641PMC

Phylogenetics: an added ingredient in HIV prevention.

Authors:
Bluma G Brenner

AIDS 2020 07;34(8):1247-1248

McGill AIDS Centre, Lady Davis Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/QAD.0000000000002521DOI Listing

Psychiatric trajectories across adolescence in perinatally HIV-exposed youth: the role of HIV infection and associations with viral load.

AIDS 2020 07;34(8):1205-1215

HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University.

Objective: Identify factors associated with trajectories of psychiatric disorder among 340 adolescents and young adults (AYA) living with perinatal HIV infection (PHIV) and perinatal HIV-exposure but not infection (PHEU).

Design: Longitudinal cohort study of AYA in New York City, 9-16 years at enrollment.

Methods: We used multivariate longitudinal latent class analysis to identify trajectories of psychiatric disorder, and logistic regression to examine predictors of trajectories (e. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002537DOI Listing

Generation of HIV-1-infected patients' gene-edited induced pluripotent stem cells using feeder-free culture conditions.

AIDS 2020 07;34(8):1127-1139

Division of Hematology/Oncology.

Objectives: The discovery of induced pluripotent stem cells (iPSC) has brought promise to regenerative medicine as it breaks the ethical barrier of using embryonic stem cells. Such cell culture-derived patient-specific autologous stem cells are needed for transplantation. Here we report deriving HIV-1-infected patients' iPSC lines under transgene-free methods and under feeder-free and xeno-free culture conditions to meet the requirement for clinical application. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002535DOI Listing

Implementation of HIV care in Western Kenya during corona virus disease 2019 response.

AIDS 2020 07;34(8):F1-F2

Department of Obstetrics, Gynecology and Reproductive Sciences, Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, California, USA.

: To ensure the continuity of high-quality HIV care in Kisumu County, Kenya during the corona virus disease 2019 pandemic, the Ministry of Health implemented a strategy to promote physical distancing and corona virus disease 2019 case detection. A total of 23 262 (84.2%) of the 27 641 patients eligible for early refill received an extra 3-month supply of antiretrovirals. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002576DOI Listing

Incidence and risk factors for tuberculosis among people with HIV on antiretroviral therapy in the UK.

AIDS 2020 Jun 4. Epub 2020 Jun 4.

Institute for Global Health, University College London, London, UK.

Objective: The UK has a low tuberculosis incidence and earlier combination antiretroviral therapy (cART) is expected to have reduced incidence among people with HIV. Epidemiological patterns and risk factors for active tuberculosis were analysed over a 20 year period among people accessing HIV care at sites participating in the UK CHIC observational study.

Design: Cohort analysis. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002599DOI Listing

HIV-1-induced changes in HLA-C*03: 04-presented peptide repertoires lead to reduced engagement of inhibitory NK cell receptors.

AIDS 2020 Jun 4. Epub 2020 Jun 4.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

Objective: Viral infections influence intracellular peptide repertoires available for presentation by HLA-I. Alterations in HLA-I/peptide complexes can modulate binding of KIRs and thereby the function of NK cells. While multiple studies have provided evidence that HLA-I/KIR interactions play a role in HIV-1 disease progression, the consequence of HIV-1 infection for HLA-I/KIR interactions remain largely unknown. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002596DOI Listing

Sterol metabolism modulates susceptibility to HIV-1 Infection.

AIDS 2020 Jun 4. Epub 2020 Jun 4.

Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157 Milan, Italy.

Background: 25-hydroxylase (CH25H) is an Interferon stimulated gene (ISG), which catalyzes the synthesis of 25-Hydroxycholesterol (25HC). 25HC intervenes in metabolic and infectious processes as controls cholesterol homeostasis and influences viral entry into host cells.We verified whether natural resistance to HIV-1 infection in HIV-1-exposed seronegative (HESN) individuals is at least partially mediated by particularities in sterol biosynthesis. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002591DOI Listing

Population-level viral suppression among pregnant and postpartum women in a universal test and treat trial.

AIDS 2020 Jul;34(9):1407-1415

University of California, San Francisco.

Objective(s): We sought to determine whether universal 'test and treat' (UTT) can achieve gains in viral suppression beyond universal antiretroviral treatment (ART) eligibility during pregnancy and postpartum, among women living with HIV.

Design: A community cluster randomized trial.

Methods: The SEARCH UTT trial compared an intervention of annual population testing and universal ART with a control of baseline population testing with ART by country standard, including ART eligibility for all pregnant/postpartum women, in 32 communities in Kenya and Uganda. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002564DOI Listing

Determining standardized causes of death of infants, children, and adolescents living with HIV in Asia.

AIDS 2020 May 20. Epub 2020 May 20.

The Kirby Institute, UNSW Sydney, Sydney, Australia, for IeDEA Asia-Pacific.

Objective: To implement a standardized cause of death (CoDe) reporting and review process in order to systematically disaggregate causes of HIV-related deaths in a cohort of Asian children and adolescents.

Design: Death-related data were retrospectively and prospectively assessed in a longitudinal regional cohort study.

Methods: Children under routine HIV care at sites in Cambodia, India, Indonesia, Malaysia, Thailand, and Vietnam between 2008-2017 were followed. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002583DOI Listing

Risk of HIV infection among adolescent girls and young women in age-disparate relationships in sub-Saharan Africa: a systematic review and meta-analysis.

AIDS 2020 May 20. Epub 2020 May 20.

Department of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, P.O. Box, 1410, Mbarara, Uganda.

Objective: To determine the association between age-disparate relationships and risk of Human Immunodeficiency Virus (HIV) infection among adolescent girls and young women (AGYW) aged 15-24 years.

Design: Systematic review and meta-analysis of published studies until January 5, 2020 in sub Saharan Africa (SSA).

Methods: We searched several electronic databases, grey literature, and hand searched reference list of included studies to identify eligible studies for data abstraction. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002582DOI Listing

High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly-diagnosed antiretroviral treatment naive children in sub-Saharan Africa.

AIDS 2020 May 20. Epub 2020 May 20.

HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.

: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002580DOI Listing
May 2020
5.554 Impact Factor

Direct maternal deaths attributable to HIV in the era of ART: evidence from three population-based HIV cohorts with verbal autopsy.

AIDS 2020 May 8. Epub 2020 May 8.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Objective: To assess whether HIV in associated with an increased risk of mortality from direct maternal complications.

Design: Population-based cohort study using data from three demographic surveillance sites in Eastern and Southern Africa.

Methods: We use verbal autopsy data, with cause of death assigned using the InSilicoVA algorithm, to describe the association between HIV and direct maternal deaths amongst women aged 20-49. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002552DOI Listing
May 2020
5.554 Impact Factor

Projecting the impact of equity-based pre-exposure prophylaxis implementation on racial disparities in HIV incidence among men who have sex with men.

AIDS 2020 May 6. Epub 2020 May 6.

Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island.

Background: It is unknown what levels of pre-exposure prophylaxis (PrEP) use are needed to reduce racial disparities in HIV incidence among men who have sex with men (MSM). Using an agent-based model (ABM), we quantified the impact of achieving PrEP coverage targets grounded in equity on racial disparities in HIV incidence among MSM in an urban setting in the Southeastern United States.

Methods: An ABM was adapted to simulate HIV transmission in a network of Black/African American and White MSM aged 18 to 39 years in the Atlanta-Sandy Springs-Roswell metropolitan area over ten years (2015-2024). Read More

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http://dx.doi.org/10.1097/QAD.0000000000002577DOI Listing
May 2020
5.554 Impact Factor

Efavirenz and cognition that matters.

AIDS 2020 06;34(7):1105-1106

Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre.

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http://dx.doi.org/10.1097/QAD.0000000000002545DOI Listing

False positive HIV testing after T-cell receptor therapy.

AIDS 2020 06;34(7):1103-1105

Institute of Human Virology.

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http://dx.doi.org/10.1097/QAD.0000000000002511DOI Listing

Thrombotic thrombocytopenic purpura associated with AIDS: challenges in diagnosis and management.

AIDS 2020 06;34(7):1101-1102

State University of New York Upstate Medical University, Syracuse, New York, USA.

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http://dx.doi.org/10.1097/QAD.0000000000002504DOI Listing

Productive HIV infection in astrocytes can be established via a nonclassical mechanism.

AIDS 2020 06;34(7):963-978

Section of Infections of the Nervous System.

Objective: Astrocytes are proposed to be a critical reservoir of HIV in the brain. However, HIV infection of astrocytes is inefficient in vitro except for cell-to-cell transmission from HIV-infected cells. Here, we explore mechanisms by which cell-free HIV bypasses entry and postentry barriers leading to a productive infection. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002512DOI Listing

Longitudinal patterns of illicit drug use, ART exposure and plasma HIV-1 RNA viral load among HIV-positive people who use illicit drugs.

AIDS 2020 Apr 16. Epub 2020 Apr 16.

British Columbia Centre on Substance Use.

Objectives: HIV-positive people who use illicit drugs (PWUD) experience elevated rates of HIV-associated morbidity and mortality compared with members of other key affected populations. Although suboptimal levels of access and adherence to antiretroviral therapy (ART) are common among HIV-positive PWUD, there is a need for studies investigating the possible biological impacts of noninjection illicit drug use among people living with HIV in real-world settings.

Methods: We accessed data from the ACCESS study, an ongoing prospective cohort of illicit drug users with systematic HIV viral load monitoring in a setting with universal care and ART dispensation records. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002551DOI Listing

Drug efflux transporters and metabolic enzymes in human circulating and testicular T-cell subsets: relevance to HIV pharmacotherapy.

AIDS 2020 Apr 16. Epub 2020 Apr 16.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

Objectives: ATP-binding cassette (ABC) drug efflux transporters and drug metabolic enzymes could reduce antiretroviral (ARV) concentrations in HIV target cells. The testis has been demonstrated to be a sanctuary site, displaying suboptimal ARV concentrations and persistent HIV infection. Therefore, we compared the expression and function of ABC transporters and metabolic enzymes in CD4 and CD8 T cells isolated from human testis and peripheral blood mononuclear cells (PBMCs), and assessed their expression in circulating naïve and memory CD4 T-cell phenotypes. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002548DOI Listing

Outcomes of immunomodulatory and biologic therapy in people living with HIV.

AIDS 2020 07;34(8):1171-1179

Division of Infectious Diseases, University of California, San Francisco, California, USA.

Objectives: Immunomodulatory drugs (IMDs) are crucial for treating autoimmune, inflammatory, and oncologic conditions. Data regarding the safety of IMDs in people living with HIV (PLWH) are limited. We describe outcomes in all PLWH prescribed these agents from 2000--2019 at two academic medical centers. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002549DOI Listing

Safety of in-utero antiretroviral exposure: neurologic outcomes in children who are HIV-exposed but uninfected.

AIDS 2020 Jul;34(9):1377-1387

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.

Objective: To evaluate whether there is an increased risk of neurologic diagnoses in children who are HIV-exposed but uninfected (CHEU) exposed in utero to specific antiretroviral medications.

Design: Prospective cohort study of CHEU enrolled from 2007 to 2017.

Methods: We evaluated children for neurologic case status, including microcephaly, febrile seizures, seizure disorders, ophthalmologic disorders, and other neurologic disorders. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002550DOI Listing

Investigating the effect of antiretroviral switch to tenofovir alafenamide on lipid profiles in people living with HIV.

AIDS 2020 07;34(8):1161-1170

Centre for Experimental Pathogen Host Research, School of Medicine, University College Dublin.

Background: Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF). We aimed to characterize changes in lipids observed after switching to TAF-containing ART in a real-world setting.

Methods: A prospective study on PLWH enrolled in the UCD-ID Cohort study who switched to TAF-containing ART. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002541DOI Listing

CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection.

AIDS 2020 07;34(8):1249-1252

Immunopathology Group, Biocruces Bizkaia Health Research Institute, Barakaldo.

: Human CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4 T cells from HIV-1-infected patients. We found that infected CD4+RA- T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002544DOI Listing

Performing rapid autopsy for the interrogation of HIV reservoirs.

AIDS 2020 06;34(7):1089-1092

Division of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.

: Rapid autopsy at the end of life in people with HIV (PWH) permits the preservation of valuable tissue specimens for subsequent study of HIV reservoirs. At our institution, we have developed a cohort of PWH who consent to a rapid autopsy to gather a wide range of fluids and tissues with the goal of advancing HIV cure research. The protocol for successfully performing these autopsies has required careful thought and development over months and years. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002546DOI Listing

Enhancing natural killer cell function with gp41-targeting bispecific antibodies to combat HIV infection.

AIDS 2020 Jul;34(9):1313-1323

Department of Medicine, Division of Infectious Diseases and Geographic Medicine.

Objective(s): The aim of this study was to develop and evaluate the activity of bispecific antibodies (bsAbs) to enhance natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) against HIV-infected cells.

Design: These bsAbs are based on patient-derived antibodies targeting the conserved gp41 stump of HIV Env, and also incorporate a high-affinity single chain variable fragment (scFv) targeting the activating receptor CD16 on NK cells. Overall, we expect the bsAbs to provide increased affinity and avidity over their corresponding mAbs, allowing for improved ADCC activity against Env-expressing target cells. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002543DOI Listing

Lung function in men with and without HIV.

AIDS 2020 07;34(8):1227-1235

University of Pittsburgh, Division of Pulmonary, Allergy and Critical Care Medicine, Pittsburgh, Pennsylvania.

Objectives: Initial studies suggest HIV-positive persons may be at increased risk for chronic lung diseases such as chronic obstructive pulmonary disease, but have commonly relied on single-center designs, lacked HIV-negative controls, or assessed lung function with only spirometry. We tested differences in spirometry and single-breath diffusing capacity for carbon monoxide (DLCO) in persons with and without HIV.

Design: Cross-sectional, observational study. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002526DOI Listing

Frailty transitions, inflammation, and mortality among persons aging with HIV infection and injection drug use.

AIDS 2020 07;34(8):1217-1225

Johns Hopkins University, Baltimore, Maryland, USA.

Objective: Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stress, predictive of major adverse clinical outcomes in HIV-infected and uninfected adults. Frailty is a dynamic state, yet little data exist on predictors and consequences of frailty transitions.

Design/methods: Frailty was assessed semiannually among HIV-infected and uninfected persons with prior injection drug use using the five Fried phenotype domains. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002527DOI Listing

Cancer risk following lymphoid malignancies among HIV-infected people.

AIDS 2020 07;34(8):1237-1245

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Objective(s): HIV-infected people have increased cancer risk. Lymphoma survivors have an increased risk of certain second primary cancers in the general population, but second cancer risk among HIV-infected people is poorly understood. Herein, we characterized the risk of cancers following lymphoid malignancies among HIV-infected people. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002528DOI Listing
July 2020
5.554 Impact Factor