13,364 results match your criteria AIDS[Journal]


The multidimensionality of masculine norms in east Zimbabwe: implications for HIV prevention, testing and treatment.

AIDS 2018 Dec 10. Epub 2018 Dec 10.

Department of Infectious Disease Epidemiology, Imperial College London School of Public Health London.

Background: Research and intervention studies suggest that men face challenges in using HIV services in sub-Saharan Africa. To address these challenges, quantitative measurements are needed to establish the individual-level determinants of masculine norms and their implications for HIV prevention and treatment programmes.

Methods: Survey questions for four masculine norms identified in qualitative research were included in a general-population survey of 3116 men in east Zimbabwe, 2012-2013. Read More

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December 2018
1 Read

Postpartum HIV care continuum outcomes in the Southeastern US.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Objective: Evaluate postpartum HIV care outcomes.

Design: Prospective clinical cohort of women with HIV and a live birth at the University of North Carolina, 1996-2014.

Methods: We estimated two stages of the HIV care continuum in the first 24 months postpartum: care retention (≥2 visits per year, ≥90 days apart) and viral suppression (HIV RNA < 400 copies/mL). Read More

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November 2018

Systemic inflammation is elevated among both HIV-uninfected and -infected young men who have sex with men.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

United States, Chicago, 60611, Utrecht University, P.O Box 80125, Antonie van Leeuwenhoeklaan 9, Netherlands.

: Evidence suggests that systemic inflammation increases due to HIV infection. C-reactive protein (CRP), IL-6, and TNF-α values were compared between HIV+ and HIV- young men who have sex with men and transgender women. CRP values were >3 mg/L among 49. Read More

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November 2018

Growing up with perinatal HIV.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, NY.

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November 2018

Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities: is it time to assess the definitions?

AIDS 2018 Nov 27. Epub 2018 Nov 27.

Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.

No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9. Read More

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November 2018

HIV controllers suppress viral replication and evolution and prevent disease progression following intersubtype HIV-1 superinfection.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

Laboratório de AIDS & Imunologia Molecular. Instituto Oswaldo Cruz (IOC) - FIOCRUZ. Rio de Janeiro, Brazil.

Objective: To investigate the impact of intersubtype HIV-1 superinfection (SI) on viremia, reservoir reseeding, viral evolution, and disease progression in HIV controllers (HIC).

Design: Longitudinal analysis of two Brazilian HIC subjects (EEC09 and VC32) previously identified as dually infected with subtypes B and F1 viruses.

Methods: Changes in plasma viremia, total HIV-1 DNA levels, CD4 T cell counts and HIV-1 quasispecies composition were measured over time. Read More

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November 2018

Microbial translocation revisited: targeting the endotoxic potential of gut microbes in HIV-infected individuals.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway.

Objective: Translocation of microbial products such as lipopolysaccharides (LPS) from the gut may contribute to chronic inflammation in HIV-infected individuals. Recent studies indicate that differences in degree of acylation of gut-bacterial derived LPS may explain variable immune effects, with hexa-acylated rather than penta-acylated LPS having pro-inflammatory capacity. We investigated whether the degree of acylation of gut-derived LPS associates with systemic inflammation, and the potential effect of probiotic intervention. Read More

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November 2018

Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

San Francisco Veterans Affairs (VA) Medical Center and University of California San Francisco (UCSF), 4150 Clement Street, 111W, San Francisco, CA 94121, USA.

Objectives: Reversing HIV-1 latency has been suggested as a strategy to eradicate HIV-1. We investigated the effect of romidepsin on the HIV transcription profile in participants from the REDUC part B clinical trial.

Design: Seventeen participants on suppressive antiretroviral therapy were vaccinated with six doses of the therapeutic vaccine Vacc-4x followed by treatment with three doses of romidepsin. Read More

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November 2018

HIV and amenorrhea: A meta-analysis.

AIDS 2018 Nov 27. Epub 2018 Nov 27.

University of British Columbia, Vancouver, Canada.

Objective: There is conflicting literature to support a link between HIV and amenorrhea. Here, we conduct a meta-analysis to summarize the results from landmark studies in this area and shed light on this important clinical association.

Methods: Using a search of Ovid Medline and Embase, a total of 322 articles were screened for controlled matched observational studies of amenorrhea in premenopausal women living with HIV (WLWH). Read More

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November 2018

HIV virological failure in a patient with human T-lymphotropic virus type 1-associated leukemia.

AIDS 2019 Jan;33(1):159-160

Division of Infectious Diseases, Saint-Pierre University Hospital, Université Libre de Bruxelles.

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January 2019

Broadening our knowledge of the differences between HIV-2 and HIV-1 innate sensing: HIV-2 infected cells selectively express B7-H6 and engage NKp30 on natural killer cells.

AIDS 2019 Jan;33(1):153-154

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.

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January 2019
1 Read

Extremely Low Hepatitis C prevalence among HIV co-infected individuals in 4 countries in sub-Saharan Africa.

AIDS 2018 Nov 16. Epub 2018 Nov 16.

Epicentre, Paris, France.

: A multicentric, retrospective case-series analysis (facility-based) in five sites across Kenya, Malawi, Mozambique, and Uganda screened HIV-positive adults for hepatitis C virus (HCV) antibodies using Oraquick rapid testing and viral confirmation (in three sites). Results found substantially lower prevalence than previously reported for these countries compared with previous reports, suggesting that targeted integration of HCV screening in African HIV programs may be more impactful than routine screening.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4. Read More

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November 2018
1 Read

HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection.

AIDS 2018 Nov 19. Epub 2018 Nov 19.

School of Medical Sciences, UNSW Medicine, UNSW Sydney, Sydney, NSW Australia.

Objective: We investigated whether HIV brain latency was associated with brain injury in virally suppressed HIV infection.

Design: observational cross-sectional and longitudinal study.

Methods: The study included 26 virally-suppressed HIV+ men (61. Read More

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November 2018
5 Reads

Success and failure of initial antiretroviral therapy in adults: an updated systematic review of 77,999 subjects from 1994 to 2017.

AIDS 2018 Nov 19. Epub 2018 Nov 19.

University of New South Wales, Sydney, Australia.

Background: We updated a prior systematic review of initial ART efficacy through Week 144.

Materials And Methods: Studies (1994-July 2017) were drawn from PubMed, ClinicalTrials.gov, Cochrane Library, and major conferences; design, eligibility, subject and ART data were abstracted. Read More

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November 2018

Strain-specific effect on biphasic DNA binding by HIV-1 integrase.

AIDS 2018 Nov 19. Epub 2018 Nov 19.

Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA.

The oligomerization of HIV-1 integrase onto DNA is not well understood. Here we show that HIV-1 integrase binds the DNA in a biphasic (high- and low-affinity) modes. For HIV-1 subtype B, the high-affinity mode is ∼100-fold greater than low-affinity mode (Kd. Read More

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November 2018
8 Reads

GlycA, a novel inflammatory marker, is associated with subclinical coronary disease in the multicenter AIDS cohort study.

AIDS 2018 Nov 19. Epub 2018 Nov 19.

Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland.

Objective: GlycA, a novel NMR biomarker of inflammation, has been associated with incident cardiovascular disease (CVD) in the general population, but its association with CVD among HIV-infected individuals is unknown. We examined the associations between GlycA and subclinical coronary plaque among HIV-infected and HIV-uninfected men participating in MACS.

Design: Cross-sectional analysis of 935 men with plasma measurement of GlycA and noncontrast cardiac computed tomography (CT) and/or coronary CT angiography. Read More

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November 2018
3 Reads

Eliminating perinatal HIV in the United States: mission possible?

AIDS 2018 Nov 19. Epub 2018 Nov 19.

ICAP at Columbia University, Mailman School of Public Health and Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.

In 2015, only 53 infants born in the United States acquired HIV, the lowest recorded number of perinatal HIV infections. Recognizing this significant achievement, we must acknowledge that the United States has not yet reached the goal of eliminating perinatal HIV transmission. This manuscript describes different approaches to perinatal HIV preventive services among five states and the District of Columbia as case studies. Read More

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November 2018
5.550 Impact Factor

Economy, migrant labour and sex work: interplay of HIV epidemic drivers in Zimbabwe over three decades.

AIDS 2019 Jan;33(1):123-131

Centre for Sexual Health and HIV AIDS Research (CeSHHAR Zimbabwe), Harare, Zimbabwe.

Background: HIV took off rapidly in Zimbabwe during the 1980s. Yet, between 1998 and 2003, as the economy faltered, HIV prevalence declined abruptly and without clear explanation.

Methods: We reviewed epidemiological, behavioural, and economic data over three decades to understand changes in economic conditions, migrant labour and sex work that may account for observed fluctuations in Zimbabwe's HIV epidemic. Read More

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January 2019
3 Reads

Considerations in evaluating infectious morbidity and mortality in HIV-exposed uninfected infants.

AIDS 2018 Nov;32(18):2855-2856

Department of Paediatrics & Child Health, Faculty of Medicine & Health Sciences, Stellenbosch University, Worcester, Western Cape, South Africa.

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November 2018
3 Reads

An implicit threat: dolutegravir-induced schizophrenic brief psychotic disorder and persistent cenesthopathy.

AIDS 2018 Nov;32(18):2853-2854

Division of Respiratory Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

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November 2018
1 Read

New insight into the mechanisms of achieving antiretroviral therapy-free HIV-1 control.

AIDS 2018 Nov;32(18):2839-2840

Department of Infectious Diseases, Aarhus University Hospital, Skejby, Aarhus, Denmark.

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November 2018
2 Reads

Non-Hodgkin lymphoma risk in adults living with HIV across five continents.

Authors:

AIDS 2018 Nov;32(18):2777-2786

Objective: To compare non-Hodgkin lymphoma (NHL) incidence rates in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America.

Methods: We included cohort data of adults living with HIV who started ART after 1995 within the framework of the International epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE). We used flexible parametric survival models to compare regional NHL rates at 2 years after ART start and to identify risk factors for NHL. Read More

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November 2018
5 Reads

Sex differences in HIV-associated cognitive impairment.

AIDS 2018 Nov;32(18):2719-2726

Department of Psychiatry, University of California, San Diego, La Jolla.

Objective: We determined whether there are sex differences in the prevalence and profile of HIV-associated neurocognitive impairment, and whether sex moderates the effect of HIV-serostatus on neurocognitive impairment among HIV-positive and HIV-negative individuals. Secondarily, we assessed whether differences were explained by greater biopsychosocial risk factors in HIV-positive women.

Design: An observational cohort study. Read More

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November 2018
1 Read

Two cases of dolutegravir failure with R263K mutation.

AIDS 2018 Nov;32(17):2639-2640

Laboratório de Biologia Molecular, LMCBM, SPC.HEM, Centro Hospitalar Lisboa Ocidental, Lisbon.

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November 2018

Multidrug nanosuspensions: future perspectives on drug delivery system for HIV combination antiretroviral therapy.

AIDS 2018 Nov;32(17):2629-2631

Dipartimento di Medicina Clinica e Sperimentale, SC Malattie Infettive, Università degli Studi di Foggia, Foggia, Italy.

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November 2018

A three-in-one, long-acting, nanosuspension reformulation of off-patent antiretrovirals for low-income and middle-income countries.

AIDS 2018 Nov;32(17):2625-2627

Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.

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November 2018

Elimination prospects of the Dutch HIV epidemic among men who have sex with men in the era of preexposure prophylaxis.

AIDS 2018 Nov;32(17):2615-2623

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht.

Objective: Preexposure prophylaxis (PrEP) is a promising intervention to help end the HIV epidemic among men who have sex with men (MSM) in the Netherlands. We aimed to assess the impact of PrEP on HIV prevalence in this population and to determine the levels of PrEP coverage necessary for HIV elimination.

Design And Methods: We developed a mathematical model of HIV transmission in a population stratified by sexual risk behavior with universal antiretroviral treatment (ART) and daily PrEP use depending on an individual's risk behavior. Read More

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November 2018

Viremia copy-years and mortality among combination antiretroviral therapy-initiating HIV-positive individuals: how much viral load history is enough?

AIDS 2018 Nov;32(17):2547-2556

Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Objective: Ongoing HIV replication while receiving combination antiretroviral therapy (cART) may reduce survival. Viremia copy-years (VCY) has shown improved mortality risk prediction over single time-point viral load measures. However, the timing of a patient's viral load history most associated with later mortality has not been studied. Read More

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November 2018

Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Unidad de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla.

Objective: To assess the performance of ultrasound (US) surveillance for the diagnosis of hepatocellular carcinoma (HCC) in HIV-infected patients.

Methods: The GEHEP-002 cohort recruits HCC cases diagnosed in HIV-infected patients from 32 centers across Spain. The proportion of 'US lack of detection', defined as HCC diagnosed within the first 3 months after a normal surveillance US, and the proportion of 'surveillance failure', defined as cases in which surveillance failed to detect HCC at early stage, were assessed. Read More

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October 2018
1 Read

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

AIDS 2018 Oct 16. Epub 2018 Oct 16.

Department of Global Health, Academic Medical Center and Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.

Objectives: Despite successful antiretroviral (ARV) therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately-chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement.

Design: Cross-sectional analysis of 134 PLWH on suppressive ARV therapy, 79 lifestyle-comparable HIV-negative controls aged ≥45 years from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors (BD). Read More

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October 2018
1 Read

B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape.

AIDS 2019 Jan;33(1):23-32

Sorbonne Université, UPMC University Paris 06, INSERM U1135, CNRS ERL8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris.

Objective: HIV-1 and HIV-2 differ notably in their epidemiology, with worldwide HIV-1 spread and HIV-2 mainly confined to West Africa. Natural killer (NK) cells are critical antiviral effectors of the immune system; however, limited information is available about these innate effector cells during HIV-2 infection.

Method: In this study, 24 untreated HIV-2-infected patients were analyzed and compared with 21 long-term nonprogressor and 10 controller HIV-1 patients, and healthy donors. Read More

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January 2019
1 Read

Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Objective: Persons living with HIV (PLWH) well-treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk.

Designs/methods: 155 HIV-infected and 70 non-HIV-infected individuals were well-phenotyped for body composition. Read More

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October 2018
7 Reads

Increased risk of anal squamous cell carcinoma in HIV-positive men with prior hepatitis B virus infection.

AIDS 2019 Jan;33(1):145-152

Department of Cancer Immunology and Virology.

Objective(s): HIV-positive individuals have elevated rates of anal squamous cell carcinoma (SCC), and sexually transmitted infections with its causative agent, high-risk human papillomavirus, and other oncoviruses including hepatitis B virus (HBV). HBV infection can cause liver cancer, and has been associated with increased risk of some extra-hepatic cancers including biliary tract cancer, pancreatic cancer, and non-Hodgkin lymphoma. Whether HBV is associated with anal SCC risk is unknown. Read More

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January 2019
3 Reads

Viral rebound in semen after antiretroviral treatment interruption in an HIV therapeutic vaccine double-blind trial.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Vaccine Research Institute (VRI), Paris, France.

Objectives: This study aimed to determine the timing and level of HIV rebound in blood and seminal plasma and to characterize the HIV rebounding populations after antiretroviral treatment interruption (ATI) in HIV-1-infected participants enrolled in a therapeutic vaccine trial.

Design: A twelve-week (W) ATI period was proposed at W36 to patients enrolled in the VRI02/ANRS149-LIGHT trial. Paired blood and semen samples were collected before (W32 or W36) and during ATI (W38, W40, W42, W44 and W48). Read More

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October 2018
9 Reads

Effects of short-term cash and food incentives on food insecurity and nutrition among HIV-infected adults in Tanzania: a randomized trial.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA.

Objective: Food insecurity (FI) impedes antiretroviral therapy (ART) adherence. We previously demonstrated that short-term cash and food incentives increased ART possession and retention in HIV services in Tanzania. To elucidate potential pathways that led to these achievements, we examined whether incentives also improved FI. Read More

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October 2018
6 Reads
5.550 Impact Factor

Sexual intermingling of arab and jewish men who have sex with men in israel: results of a molecular epidemiology study.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Central Virology Laboratory, Sheba Medical Center, Ministry of Health, Ramat-Gan, Israel.

Objectives: Men who have sex with men (MSM) comprise ∼30% of new HIV infections in Israel, a country with mixed Jewish and Arab populations. We molecularly characterized HIV-1 in the Arab and Jewish MSM (AMSM, JMSM) populations to reveal possible inter-ethnical connections.

Design: Cross-sectional study METHODS:: All Israeli-born, HIV-1-infected MSM diagnosed between 2005 and 2016 (n = 1143) were cross-matched with the National Civil Registry to identify religion (Jews/Muslim/Christian). Read More

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October 2018

Mild renal impairment is associated with calcified plaque parameters assessed by CT angiography in people living with HIV.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Objective: To investigate the association of mild renal impairment and coronary plaque in people living with HIV (PLHIV).

Methods: PLHIV and non-HIV controls with serum creatinine <1.5 mg/dL were investigated. Read More

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October 2018
1 Read

Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town.

Objective: Both isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) reduce tuberculosis risk in individuals living with HIV. We sought to estimate the broader, population-wide impact of providing a pragmatically-implemented 12-month IPT regimen to ART recipients in a high-burden community.

Design: Dynamic transmission model of a tuberculosis-HIV epidemic, calibrated to site-specific, historical epidemiologic and clinical trial data from Khayelitsha, South Africa. Read More

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October 2018
2 Reads

Death after diagnosis of non-communicable disease comorbid conditions, stratified by injection drug use.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Objective: Describe all-cause mortality associated with history of injection drug use (IDU) after a validated diagnosis of four non-communicable disease (NCD) diagnoses: 1) end-stage liver disease (ESLD); 2) end-stage renal disease (ESRD); 3) cancer; or 4) myocardial infarction (MI) or stroke.

Design: We followed 4 cohorts of persons in continuity HIV care in the Johns Hopkins HIV Clinic with a validated diagnosis of ESLD (n = 67), ESRD (n = 187), cancer (n = 424), and MI or stroke (n = 213) from 1996 through approximately 2014.

Methods: Crude and adjusted Cox proportional hazards models to estimate hazard ratios [HR] for death after a validated diagnosis of one of four NCD diagnoses associated with history of IDU as an HIV acquisition risk factor. Read More

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October 2018
1 Read

Reconstitution of HIV-1 reservoir following high-dose chemotherapy/autologous stem cell transplantation for lymphoma.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

INSERM U941, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris, France.

Objectives: autologous stem cell transplantation following high-dose chemotherapy (HDC/ASCT) is the prime model to study the impact of HDC in HIV-1-infected participants. We analyzed the impact of HDC/ASCT on the resurgent reservoir composition and origin.

Design: We included retrospectively a homogenous group of HIV-1-infected patients treated for high-risk lymphoma in a reference center with consistent chemotherapy regimen. Read More

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October 2018
3 Reads

Behavioral changes following HIV seroconversion during the historical expansion of HIV treatment in the United States.

AIDS 2019 Jan;33(1):113-121

Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts, USA.

Objectives: To identify the ways in which HIV seroconversion impacts subsequent health behaviors in the context of evolving HIV treatment technologies.

Design: Prospective cohort study.

Methods: We assessed changes in health and HIV risk behaviors following HIV seroconversion both before and after HIV treatment access (i. Read More

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January 2019
4 Reads

The effect of primary drug resistance on CD4 cell decline and the viral load set-point in HIV positive individuals before the start of antiretroviral therapy.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan.

Objective: To evaluate the effect of primary resistance and selected polymorphic amino-acid substitutions in HIV reverse transcriptase (RT) and protease (PR) on the CD4 count and viral load (VL) set point before the start of ART.

Design: Prospective cohort study.

Methods: 6,180 individuals with a resistance test prior to starting ART accessing care in HIV clinics across Europe who had at least 1 VL and 1 CD4 test available were included in the analysis. Read More

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October 2018
1 Read

NRTI backbones and pregnancy outcomes: results from a European cohort collaboration.

Authors:

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Objectives: to investigate whether specific nucleoside reverse transcriptase inhibitor (NRTI) backbones are associated with risk of adverse pregnancy outcomes among pregnant women starting antiretroviral therapy (ART) DESIGN:: Seven observational studies across eight European countries of pregnancies in HIV-positive women METHODS:: Individual-level data were pooled on singleton pregnancies conceived off-ART in which a single combination ART regimen was initiated ≥2 weeks before delivery, and ending in a live birth in 2008-2014. Preterm delivery (PTD) was defined as <37 gestational weeks and small-for-gestational-age (SGA) as <10 percentile according to INTERGROWTH standards. Poisson regression models were fitted to investigate associations between NRTI backbones and PTD/SGA. Read More

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October 2018
3 Reads

Effect of incident hepatitis C infection on CD4 count and HIV RNA trajectories based on a multinational HIV seroconversion cohort.

AIDS 2018 Oct 15. Epub 2018 Oct 15.

Department of Infectious Disease Research and Prevention, Public Health Service of Amsterdam, Amsterdam, the Netherlands.

Background: Most studies on hepatitis C virus (HCV)/HIV co-infection do not account for the order and duration of these two infections. We aimed to assess the effect of incident HCV infection, and its timing relative to HIV seroconversion (HIVsc) in HIV-positive men who have sex with men (MSM) on their subsequent CD4 T-cell count (CD4) and HIV-RNA viral load (VL) trajectories.

Methods: We included MSM with well-estimated dates of HIVsc from 17 cohorts within the CASCADE Collaboration. Read More

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October 2018
6 Reads