73,782 results match your criteria ADVANCE for Nurses[Journal]


[Advance research directives in the context of dementia research: Ethical reflections on the disclosure requirement].

Fortschr Neurol Psychiatr 2019 Feb 20. Epub 2019 Feb 20.

Ruhr-Universität Bochum, Medizinische Fakultät, Institut für medizinische Ethik und Geschichte der Medizin.

In November 2016, the German Federal Diet adopted an amendment to the German Medicinal Products Act (Arzneimittelgesetz), which permits non-therapeutic biomedical research on incompetent adults under a number of strict conditions. One of these conditions is that the potential research participant has declared her wish to participate in biomedical research in a valid research advance directive. Before completing the research advance directive, the potential research participant must be informed about the circumstances of research participation. Read More

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http://dx.doi.org/10.1055/a-0664-7980DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019

Bundled Defect-Rich MoS for a High-Rate and Long-Life Sodium-Ion Battery: Achieving 3D Diffusion of Sodium Ion by Vacancies to Improve Kinetics.

Small 2019 Feb 20:e1805405. Epub 2019 Feb 20.

Shaannxi Materials Analysis and Research Center, State Key Laboratory of Solidification Processing, School of Materials Science, Northwestern Polytechnical University, Xi'an, 710072, China.

Molybdenum disulfide (MoS ), a 2D-layered compound, is regarded as a promising anode for sodium-ion batteries (SIBs) due to its attractive theoretical capacity and low cost. The main challenges associated with MoS are the low rate capability suffering from the sluggish kinetics of Na intercalation and the poor cycling stability owning to the stack of MoS sheets. In this work, a unique architecture of bundled defect-rich MoS (BD-MoS ) that consists of MoS with large vacancies bundled by ultrathin MoO is achieved via a facile quenching process. Read More

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http://dx.doi.org/10.1002/smll.201805405DOI Listing
February 2019

Bayesian personalized treatment selection strategies that integrate predictive with prognostic determinants.

Biom J 2019 Feb 20. Epub 2019 Feb 20.

Quantitative Health Sciences and The Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

The evolution of "informatics" technologies has the potential to generate massive databases, but the extent to which personalized medicine may be effectuated depends on the extent to which these rich databases may be utilized to advance understanding of the disease molecular profiles and ultimately integrated for treatment selection, necessitating robust methodology for dimension reduction. Yet, statistical methods proposed to address challenges arising with the high-dimensionality of omics-type data predominately rely on linear models and emphasize associations deriving from prognostic biomarkers. Existing methods are often limited for discovering predictive biomarkers that interact with treatment and fail to elucidate the predictive power of their resultant selection rules. Read More

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http://dx.doi.org/10.1002/bimj.201700323DOI Listing
February 2019

Identifying indicators of aesthetics in the Great Barrier Reef for the purposes of management.

PLoS One 2019 20;14(2):e0210196. Epub 2019 Feb 20.

Pollinate, Sydney, New South Wales, Australia.

The aesthetic appreciation of natural places is one of the most fundamental ways in which people relate to their environment. It provides wellbeing, an opportunity for recreation and reflection, a sense of place, and cultural enrichment. It also motivates people to take care of natural places and to conserve them for current and future appreciation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210196PLOS
February 2019

Integrative Gene Selection on Gene Expression Data: Providing Biological Context to Traditional Approaches.

J Integr Bioinform 2018 Dec 22. Epub 2018 Dec 22.

Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany.

The advance of high-throughput RNA-Sequencing techniques enables researchers to analyze the complete gene activity in particular cells. From the insights of such analyses, researchers can identify disease-specific expression profiles, thus understand complex diseases like cancer, and eventually develop effective measures for diagnosis and treatment. The high dimensionality of gene expression data poses challenges to its computational analysis, which is addressed with measures of gene selection. Read More

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http://dx.doi.org/10.1515/jib-2018-0064DOI Listing
December 2018

Prevalence of advance care directives in the community: A telephone survey of three Australian States.

Intern Med J 2019 Feb 20. Epub 2019 Feb 20.

Australian Centre for Health Law Research, Queensland University of Technology.

Background: The community prevalence of advance care directives (ACDs) is low despite known benefits of advance care planning for patients, families and health professionals.

Aim: To determine the community prevalence of instructional and appointing ACDs in New South Wales, Victoria and Queensland and factors associated with completion of these documents.

Methods: A telephone survey of adults living in New South Wales, Victoria and Queensland (n=1175) about completion of instructional ACDs (making their own decisions about future health care) and appointing ACDs (appointing another to decide). Read More

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http://dx.doi.org/10.1111/imj.14261DOI Listing
February 2019

Development and testing of a multicomponent obesogenic built environment measure for youth using kernel density estimations.

Health Place 2019 Feb 18;56:174-183. Epub 2019 Feb 18.

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, United States.

Innovative measures can advance the measurement and understanding of obesogenic environments on health outcomes. In a southeastern US county, public parks (n = 103) were scored using detailed audit data, while two databases of food stores and restaurants were compiled (n = 1112). Using kernel density estimations, separate raster (pixel) surfaces were created for each built environment component. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.01.011DOI Listing
February 2019

Selenium enhanced phytoremediation of diesel contaminated soil by Alternanthera philoxeroides.

Ecotoxicol Environ Saf 2019 Feb 18;173:347-352. Epub 2019 Feb 18.

Engineering Research Center of Eco-environment in Three Gorges Reservoir Region, Ministry of Education, China Three Gorges University, Daxue Road 8#, Yichang 443002, PR China. Electronic address:

Using a 60-day pot culture experiment, we investigated the effect of selenium on phytoremediation of soil containing high-level diesel by Alternanthera philoxeroides (alligator weed). Diesel (20 g kg) decreased the growth of A. philoxeroides and induced oxidative stress, as indicated by tissue levels of hydrogen peroxide (HO) and malondialdehyde (MDA). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.040DOI Listing
February 2019

Direct filtration for the treatment of the coagulated domestic sewage using flat-sheet ceramic membranes.

Chemosphere 2019 Feb 11;223:383-390. Epub 2019 Feb 11.

Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Shenzhen Engineering Research Laboratory for Sludge and Food Waste Treatment and Resource Recovery, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China; Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China. Electronic address:

Direct membrane filtration (DMF) is considered as a promising technology for municipal wastewater treatment. We utilized an innovative application of flat-sheet ceramic membranes (FSCM) for DMF for the rapid treatment of domestic sewage. Coagulation was applied before FSCM filtration to increase the pollutant removal and to mitigate membrane fouling. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.055DOI Listing
February 2019

Urban heat islands advance the timing of reproduction in a social insect.

J Therm Biol 2019 Feb 11;80:119-125. Epub 2019 Jan 11.

Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA.

For many species, the timing of life cycle events is advancing under contemporary global climate change. However, much less is known regarding phenological shifts as a result of other sources of anthropogenic change, such as urban warming. In both cases, progress has been hampered by a focus on phenological traits such as the timing of emergence, rather than the phenology of more directly related fitness traits such as the timing of reproduction. Read More

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http://dx.doi.org/10.1016/j.jtherbio.2019.01.004DOI Listing
February 2019

Enzyme colocalization in protein-based hydrogels.

Methods Enzymol 2019 8;617:265-285. Epub 2019 Feb 8.

Department of Chemical and Environmental Engineering, University of California, Riverside, CA, United States. Electronic address:

The development of biomaterials with embedded enzymatic activities has been driven by a range of applications including tissue engineering, biosensors, and bioenergy applications. Advances in the design and production of peptide-based biomaterials have inspired protein engineers to begin creating enzymes with self-assembling, biomaterial forming capabilities. Outfitting enzymes with cross-link forming domains allows biomaterials to be created with a range of benefits including simple low-cost production, homogenous dispersion of activity in the hydrogels, and the ability to colocalize enzymes to create multistep cascades in the hydrogels. Read More

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http://dx.doi.org/10.1016/bs.mie.2018.12.006DOI Listing
February 2019

Changes in Patient Safety Culture: A Patient Safety Intervention for Finnish Forensic Psychiatric Hospital Staff.

J Nurs Manag 2019 Feb 19. Epub 2019 Feb 19.

Department of Nursing Science, University of Eastern Finland, Kuopio, Finland.

Aim: To evaluate how a three-year patient safety intervention, more specifically, the implementation of a patient safety incident reporting system (PSiRS), influences patient safety culture (PSC).

Background: Positive PSC improves both the quality of health care and patient safety. Nevertheless, nursing managers need tools that can help them develop and evaluate PSC. Read More

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http://doi.wiley.com/10.1111/jonm.12760
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http://dx.doi.org/10.1111/jonm.12760DOI Listing
February 2019
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Human Circadian Phase-Response Curves for Exercise.

J Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, University of California, San Diego, CA.

Key Points: Exercise elicits circadian phase-shifting effects, but additional information is needed. The phase-response curve describing the magnitude and direction of circadian rhythm phase shifts depending on the time of the zeigeber (time cue) stimulus is the most fundamental chronobiological tool for alleviating circadian misalignment and related morbidity. 51 older and 48 young adults followed a circadian rhythms measurement protocol for up to 5. Read More

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http://dx.doi.org/10.1113/JP276943DOI Listing
February 2019

Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.

Drug Deliv Transl Res 2019 Feb 19. Epub 2019 Feb 19.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.

Strategies that control the differentiation of mesenchymal stem cells (MSC) and enable image-guided cell implantation and longitudinal monitoring could advance MSC-based therapies for bone defects and injuries. Here we demonstrate a multifunctional nanoparticle system that delivers resveratrol (RESV) intracellularly to improve osteogenesis and enables photoacoustic imaging of MSCs. RESV-loaded nanoparticles (RESV-NPs), formulated from poly (lactic-co-glycolic) acid and iron oxide, enhanced the stability of RESV by 18-fold and served as photoacoustic tomography (PAT) contrast for MSCs. Read More

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http://dx.doi.org/10.1007/s13346-019-00621-6DOI Listing
February 2019

AAV-Mediated Gene Delivery to the Lung.

Methods Mol Biol 2019 ;1950:361-372

Department of Pathobiology, University of Guelph, Guelph, ON, Canada.

Adeno-associated virus (AAV) vectors are an efficient method of gene delivery to various tissues including the lung. Mouse models are often used as a preliminary preclinical model in order to advance AAV lung gene therapy vectors. In this chapter we describe an AAV purification protocol using heparin affinity chromatography as well as an intranasal and intratracheal method of delivering AAV vectors to the lungs of mice. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_21DOI Listing
January 2019

Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.

Neurosci Bull 2019 Feb 19. Epub 2019 Feb 19.

Institute of Basic Medical Sciences, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.

In this study, the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4. Read More

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http://dx.doi.org/10.1007/s12264-019-00343-2DOI Listing
February 2019

Advance of Seriniquinone Analogues as Melanoma Agents.

ACS Med Chem Lett 2019 Feb 6;10(2):186-190. Epub 2019 Feb 6.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, United States.

Seriniquinone, a marine natural product, displayed potent cytotoxicity and selectivity against melanoma cancer cells. This selectivity, combined with a novel mode of action (MOA), prompted studies to translate a pharmacologically relevant lead. Herein, we report on structure-activity relationships (SARs), and provide a strategy to prepare analogues that retain activity and offer an improved water solubility and isomeric purity. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378664PMC
February 2019

Advancing Health Equity With Lifestyle Medicine.

Authors:
Jennifer Rooke

Am J Lifestyle Med 2018 Nov-Dec;12(6):472-475. Epub 2018 Jun 14.

Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, Georgia.

The Optimal Health and Wellness Clinic of Morehouse Healthcare seeks to advance health equity by providing lifestyle medicine services to its predominantly African American patient population. Health equity means eliminating health disparities by providing services that meet the needs of the population served. African Americans have a higher burden of cardiovascular disease and diabetes than other American ethnic groups. Read More

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http://dx.doi.org/10.1177/1559827618780680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367876PMC

Dynamic Networks that Drive the Process of Irreversible Step-Growth Polymerization.

Sci Rep 2019 Feb 19;9(1):2276. Epub 2019 Feb 19.

University of Amsterdam, Van't Hoff Institute for Molecular Sciences, Amsterdam, 1090 GE, The Netherlands.

Many research fields, reaching from social networks and epidemiology to biology and physics, have experienced great advance from recent developments in random graphs and network theory. In this paper we propose a generic model of step-growth polymerisation as a promising application of the percolation on a directed random graph. This polymerisation process is used to manufacture a broad range of polymeric materials, including: polyesters, polyurethanes, polyamides, and many others. Read More

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http://dx.doi.org/10.1038/s41598-018-37942-4DOI Listing
February 2019

Retrospective cohort analysis of real-life decisions about end-of-life care preferences in a Southeast Asian country.

BMJ Open 2019 Feb 19;9(2):e024662. Epub 2019 Feb 19.

Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Objective: To describe the end-of-life care preferences of individuals, and to examine the influence of age and gender on these preferences.

Design, Setting And Participants: A retrospective cohort study was conducted. Participants included all adults (≥21 years old) (n=3380) who had completed a statement of their preferences as part of a national Advance Care Planning (ACP) programme in Singapore. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02466
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http://dx.doi.org/10.1136/bmjopen-2018-024662DOI Listing
February 2019
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Randomised controlled trial of the impact of haemodiafiltration on uraemic neuropathy: FINESSE study protocol.

BMJ Open 2019 Jan 15;9(1):e023736. Epub 2019 Jan 15.

Renal and Metabolic, The George Institute for Global Health, UNSW, Newtown, New South Wales, Australia.

Introduction: The majority of patients undergoing haemodialysis (HD) show evidence of uraemic neuropathy, a condition with no known disease-modifying treatments. The pathogenesis of uraemic neuropathy is poorly understood, but may be related to cumulative exposure to middle molecules or other solutes such as potassium. It is not known whether haemodiafiltration (HDF) reduces the progression of uraemic neuropathy. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023736DOI Listing
January 2019

Income inequality and firearm homicide in the US: a county-level cohort study.

Inj Prev 2019 Feb 19. Epub 2019 Feb 19.

Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.

Objective: Income inequality has been rising in the US and thought to be associated with violence especially homicide. About 75% of homicides involve firearms. We quantified the association between county-level income inequality and all-race/ethnicity and race/ethnicity-specific firearm homicide rates among individuals aged 14-39 years. Read More

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http://dx.doi.org/10.1136/injuryprev-2018-043080DOI Listing
February 2019
1 Read

Atypical diaphyseal femoral fractures: Considerations on surgical technique.

Injury 2019 Feb 2. Epub 2019 Feb 2.

Department of Musculoskeletal Oncology, "Palazzo Baleani" Umberto I University Hospital, Rome, Italy.

In the last two decades bisphosphonates (BP) has become the mainstream therapy for osteoporosis and the benefit in reducing the incidence of fractures has been well demonstrated in several studies, together with the drug long term (5-10 years) efficacy and safety. A complication of the long-term use of bisphosphonates is a low-energy stress fractures located in the sub-trochanteric region and the femoral shaft called atypical femur fracture (AFF). These stress fractures can be seen on plain radiographs as simple transverse patterns, with unicortical beaking and hypertrophy of the diaphyseal lateral cortex. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.048DOI Listing
February 2019

Review of evidence based clinical practice guidelines developed in Latin America and Caribbean during the last decade: an analysis of the methods for grading quality of evidence and topic prioritization.

Global Health 2019 Feb 19;15(1):14. Epub 2019 Feb 19.

Clinical Research Institute and Health Technology Assessment Unit, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá D.C., Colombia.

Background: In the last decade, efforts have been made in Latin America and the Caribbean to advance in the methodological development of evidence based clinical practice guidelines, among other strategies to improve the health provision of services and indicators.

Objectives: To build an evidence map to show the regional GRADE impact in developing clinical practice guidelines and contrast the results with current needs.

Methods: A systematic literature search was conducted in databases, developer's websites, health ministries, repositories and grey literature. Read More

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http://dx.doi.org/10.1186/s12992-019-0455-0DOI Listing
February 2019

First Report of Beet black scorch virus in the United States.

Plant Dis 2006 Jun;90(6):828

USDA-ARS, Red River Valley Agricultural Research Center, Fargo, ND 58105.

In October of 2005, sugar beet (Beta vulgaris L.) plants exhibiting symptoms of rhizomania caused by Beet necrotic yellow vein virus (BNYVV) (3) were observed in a production field near Greeley, CO. The roots of seven plants exhibiting moderate to severe symptoms characteristic of this disease were tested using double-antibody sandwich enzyme-linked immunosorbent assay with anti-BNYVV antiserum from rabbits. Read More

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http://dx.doi.org/10.1094/PD-90-0828BDOI Listing

First Report of Alternaria dianthicola Causing Leaf Blight on Withania somnifera from India.

Plant Dis 2007 Apr;91(4):467

Botany Department, Calcutta University, Kolkata, West Bengal, India.

Withania somnifera (L.) Dunal, a potential medicinal plant used for the treatment of nervous disorders, intestinal infection, leprosy, and cancer, is a perennial herb belonging to Solanaceae and distributed throughout the drier parts of India. Leaf blight disease of this plant generally occurs during March in various districts of South Bengal, India. Read More

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http://dx.doi.org/10.1094/PDIS-91-4-0467BDOI Listing

Long-Term Prediction of Soybean Rust Entry into the Continental United States.

Plant Dis 2006 Jul;90(7):840-846

Scripps Institution of Oceanography, UCSD, 0224, La Jolla, CA 92093.

This special report demonstrates the feasibility of long-term prediction of intercontinental dispersal of Phakopsora pachyrhizi spores, the causal agent of the devastating Asian soybean rust (SBR) that invaded the continental United States in 2004. The climate-dispersion integrated model system used for the prediction is the combination of the particle transport and dispersion model (HYSPLIT_4) with the regional climate prediction model (MM5). The integrated model system predicts the trajectory and concentration of P. Read More

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http://dx.doi.org/10.1094/PD-90-0840DOI Listing

Cardiovascular complications of diabetes: recent insights in pathophysiology and therapeutics.

Expert Rev Endocrinol Metab 2011 Sep;6(5):689-696

b Institut Pasteur Korea, Seoul, South Korea.

Cardiovascular complications represent the principal cause of death in patients with Type 2 diabetes. It is therefore of great importance to dissect the genetic determinants and molecular mechanisms responsible for diabetic cardiovascular complications. New research is of particular importance since, somewhat unexpectedly, large-scale clinical trials have indicated that glycemic control does not appear to have the anticipated major influence as a factor dictating cardiovascular outcome in diabetics. Read More

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http://dx.doi.org/10.1586/eem.11.63DOI Listing
September 2011

'Observing' diabetic neuropathy with corneal confocal microscopy: the effect of improvement of risk factors.

Authors:
Petr Boucek

Expert Rev Endocrinol Metab 2011 Nov;6(6):773-775

a Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague 4, Czech Republic.

Evaluation of: Tavakoli M, Kallinikos P, Iqbal A et al. Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy. Diabet. Read More

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http://dx.doi.org/10.1586/eem.11.71DOI Listing
November 2011

Routine blood pressure lowering and intensive glucose control in patients with Type 2 diabetes: the ADVANCE trial.

Expert Rev Endocrinol Metab 2009 Mar;4(2):111-118

e The George Institute for International Health, University of Sydney, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

The Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial investigated the effects of routine blood pressure lowering and intensive blood glucose control on major vascular events in people with Type 2 diabetes. In this factorial randomized study, 11,140 individuals with Type 2 diabetes were randomly assigned to a fixed combination of perindopril and indapamide or matching placebo, and to intensive glucose control with the use of modified-release gliclazide plus other drugs required to achieve a hemoglobin A1c of 6.5% of less, or standard guideline-based glucose control. Read More

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http://dx.doi.org/10.1586/17446651.4.2.111DOI Listing

Linking diabetes and atherosclerosis.

Expert Rev Endocrinol Metab 2009 Nov;4(6):603-624

c Baker IDI Heart and Diabetes Institute, JDRF Centre for Diabetes Complications, 75 Commercial Road, Melbourne, 3004 Victoria, Australia.

Cardiovascular diseases are the major causes of morbidity and mortality in people with diabetes. Macroangiopathy in diabetes is manifested by more accelerated and progressive atherosclerosis, which is more widely distributed. The pathogenesis of this accelerated atherosclerosis is multifactorial and includes very complex interactions. Read More

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http://dx.doi.org/10.1586/eem.09.46DOI Listing
November 2009

Genotypes A and B of Cadophora gregata Differ in Ability to Colonize Susceptible Soybean.

Plant Dis 2007 May;91(5):574-580

Department of Plant Pathology, Iowa State University, Ames 50011.

Growth chamber experiments were conducted to determine if extent of colonization of soybean stems by genotypes A and B of Cadophora gregata (Phialophora gregata), the causal agent of brown stem rot (BSR) of soybean, is similar in soybean plants resistant or susceptible to genotype A. Upon introduction of the two genotypes separately into the base of stems of 2-week-old seedlings, genotype A advanced with the growing tips of susceptible but not resistant genotypes. In contrast, genotype B did not advance with the growing tips of either resistant or susceptible soybean. Read More

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http://dx.doi.org/10.1094/PDIS-91-5-0574DOI Listing

Translational Control using an Expanded Genetic Code.

Authors:
Yusuke Kato

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO), Oowashi 1-2, Tsukuba, Ibaraki 305-8634, Japan.

A bio-orthogonal and unnatural substance, such as an unnatural amino acid (Uaa), is an ideal regulator to control target gene expression in a synthetic gene circuit. Genetic code expansion technology has achieved Uaa incorporation into ribosomal synthesized proteins in vivo at specific sites designated by UAG stop codons. This site-specific Uaa incorporation can be used as a controller of target gene expression at the translational level by conditional read-through of internal UAG stop codons. Read More

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http://dx.doi.org/10.3390/ijms20040887DOI Listing
February 2019

Enhancing the Energy Density of Tricritical Ferroelectrics for Energy Storage Applications.

Materials (Basel) 2019 Feb 18;12(4). Epub 2019 Feb 18.

State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an 710049, China..

Recently, tricritical ferroelectrics have been drawn tremendous attention, owing to their ultrahigh dielectric permittivities of up to > 5 × 10⁴, and their consideration for prototype materials in the development of high-performance energy storage devices. Nevertheless, such a materials system suffers from the disadvantage of low breakdown strength, which makes its energy density far from the satisfactory level for practical application. In this paper, a material-modification approach has been reported, for improving the dielectric strength for tricritical ferroelectric materials Ba(TiSn)O₃ (BTS) through doping with BiZnNbO₇ (BZN) additives. Read More

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http://dx.doi.org/10.3390/ma12040611DOI Listing
February 2019

3D Path Planning for the Ground Robot with Improved Ant Colony Optimization.

Sensors (Basel) 2019 Feb 16;19(4). Epub 2019 Feb 16.

School of Technology, Beijing Forestry University, Beijing 100083, China.

Path planning is a fundamental issue in the aspect of robot navigation. As robots work in 3D environments, it is meaningful to study 3D path planning. To solve general problems of easily falling into local optimum and long search times in 3D path planning based on the ant colony algorithm, we proposed an improved the pheromone update and a heuristic function by introducing a safety value. Read More

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http://dx.doi.org/10.3390/s19040815DOI Listing
February 2019

Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease: Rationale, design, and implementation of a pragmatic comparative effectiveness trial.

Contemp Clin Trials 2019 Feb 16. Epub 2019 Feb 16.

Division of Neurology, University of Alberta, 11350-83 Avenue, 7-112 Clinical Sciences Building, Edmonton, AB T6G 2G3, Canada. Electronic address:

Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better meet these needs. While PC has been shown to improve care and quality of life (QOL) for people with cancer and heart failure, few studies have evaluated the role of PC for people with PDRD. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.005DOI Listing
February 2019
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A Novel Approach to Infectious Disease Preparedness: Incorporating Investigational Therapeutics and Research Objectives into Full-Scale Exercises.

Health Secur 2019 Jan/Feb;17(1):54-61

Christopher J. Kratochvil, MD, is Associate Vice Chancellor for Clinical Research, University of Nebraska Medical Center; Vice President for Research, Nebraska Medicine; and Chief Medical Officer, UNeHealth, National Ebola Training and Education Center, Omaha, Nebraska.

The use of investigational therapeutics in the care of patients with Ebola virus disease was documented in the literature following the 2013-2016 outbreak. In order to access these types of therapeutics, facilities must have processes in place to quickly and efficiently activate study protocols, obtain the medications, and administer them in a timely manner. Testing these procedures in advance of a real-world event is crucial to ensuring successful implementation and execution. Read More

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http://dx.doi.org/10.1089/hs.2018.0100DOI Listing
February 2019

A Cinchona Alkaloid Antibiotic that Appears to Target ATP Synthase in Streptococcus pneumoniae.

J Med Chem 2019 Feb 19. Epub 2019 Feb 19.

Optochin, a cinchona alkaloid derivative discovered over 100 years ago, possesses highly selective antibacterial activity towards Streptococcus pneumoniae. Pneumococcal disease remains the leading source of bacterial pneumonia and meningitis worldwide. The structure activity relationships of optochin were examined through modification to both the quinoline and quinuclidine subunits, which led to the identification of analogue 48 with substantially improved activity. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01353DOI Listing
February 2019

Short photoperiod reduces the temperature sensitivity of leaf-out in saplings of Fagus sylvatica but not in Horse chestnut.

Glob Chang Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of biology, University of Antwerp, Antwerp, Belgium.

Leaf phenology is one of the most reliable bioindicators of ongoing global warming in temperate and boreal zones because it is highly sensitive to temperature variation. A large number of studies have reported advanced spring leaf-out due to global warming, yet the temperature sensitivity of leaf-out has significantly decreased in temperate deciduous tree species over the past three decades. One of the possible mechanisms is that photoperiod is limiting further advance to protect the leaves against potential damaging frosts. Read More

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http://dx.doi.org/10.1111/gcb.14599DOI Listing
February 2019

Decision-making for older patients by Australian and New Zealand doctors with Advance Care Directives: A vignette based study.

Intern Med J 2019 Feb 18. Epub 2019 Feb 18.

MStrokeMgt. Advance Care Planning Department Alfred Health.

Background: Little is known about doctors' decision-making patterns when using Advance Care Directives (ACDs) particularly for older patients in Australia and New Zealand.

Aims: To determine the level of agreement amongst Australian and New Zealand doctors' decisions when using ACDs to guide treatment decisions for older patients. To evaluate factors that may affect decision-making including doctors' demographics, vignette complexity and ACD content. Read More

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http://dx.doi.org/10.1111/imj.14263DOI Listing
February 2019

Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets.

Am J Primatol 2019 Feb 18:e22956. Epub 2019 Feb 18.

Department of Pharmacology, Center of Research in Advance Studies, Mexico City, Mexico.

Microglia are cells that protect brain tissue from invading agents and toxic substances, first by releasing pro-inflammatory cytokines, and thereafter by clearing tissue by phagocytosis. Microglia express ferritin, a protein with ferroxidase activity capable of storing iron, a metal that accumulates in brain during aging. Increasing evidence suggests that ferritin plays an important role in inflammation. Read More

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http://dx.doi.org/10.1002/ajp.22956DOI Listing
February 2019

The experience of intolerance of uncertainty for young people with a restrictive eating disorder: a pilot study.

Eat Weight Disord 2019 Feb 16. Epub 2019 Feb 16.

Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK.

Purpose: Research is consistently reporting elevated levels of intolerance of uncertainty (IU) in individuals with an eating disorder (ED). Less is known about the phenomenology of uncertainty for this clinical group. The present study aims to advance our understanding of the relationship between IU and restrictive EDs by providing insight into young people's subjective experiences of uncertainty. Read More

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http://dx.doi.org/10.1007/s40519-019-00652-5DOI Listing
February 2019

[The neural mechanism of visual contour integration].

Sheng Li Xue Bao 2019 Feb;71(1):45-52

School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China.

The human visual system efficiently extracts local elements from cluttered backgrounds and integrates these elements into meaningful contour perception. This process is a critical step before object recognition, in which contours often play an important role in defining the shapes and borders of the to-be-recognized objects. However, the neural mechanism of the contour integration is still under debate. Read More

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February 2019

Recombinant Sialyltransferase Infusion Mitigates Infection-Driven Acute Lung Inflammation.

Front Immunol 2019 4;10:48. Epub 2019 Feb 4.

Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Inappropriate inflammation exacerbates a vast array of chronic and acute conditions with severe health risks. In certain situations, such as acute sepsis, traditional therapies may be inadequate in preventing severe organ damage or death. We have previously shown cell surface glycan modification by the circulating sialyltransferase ST6Gal-1 regulates inflammatory cell production via a novel extrinsic glycosylation pathway. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369197PMC
February 2019

Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health.

Front Endocrinol (Lausanne) 2019 4;10:33. Epub 2019 Feb 4.

Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States.

Metabolic disease rates have increased dramatically over the last four decades. Classic understanding of metabolic physiology has attributed these global trends to decreased physical activity and caloric excess; however, these traditional risk factors insufficiently explain the magnitude and rapidity of metabolic health deterioration. Recently, the novel contribution of environmental metabolism-disrupting chemicals (MDCs) to various metabolic diseases (including obesity, diabetes, and non-alcoholic fatty liver disease) is becoming recognized. Read More

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http://dx.doi.org/10.3389/fendo.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369180PMC
February 2019

Polyscore of Non-invasive Cardiac Risk Factors.

Front Physiol 2019 4;10:49. Epub 2019 Feb 4.

Klinik für Innere Medizin I, Technische Universität München, Munich, Germany.

Non-invasive risk stratification of cardiac patients has been the subject of numerous studies. Most of these investigations either researched unique risk predictors or compared the predictive power of different predictors. Fewer studies suggested a combination of a small number of non-invasive indices to increase the accuracy of high-risk group selection. Read More

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http://dx.doi.org/10.3389/fphys.2019.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369149PMC
February 2019

Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer.

Nat Ecol Evol 2019 Feb 18. Epub 2019 Feb 18.

Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.

Heterogeneity in strategies for survival and proliferation among the cells that constitute a tumour is a driving force behind the evolution of resistance to cancer therapy. The rules mapping the tumour's strategy distribution to the fitness of individual strategies can be represented as an evolutionary game. We develop a game assay to measure effective evolutionary games in co-cultures of non-small cell lung cancer cells that are sensitive and resistant to the anaplastic lymphoma kinase inhibitor alectinib. Read More

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http://dx.doi.org/10.1038/s41559-018-0768-zDOI Listing
February 2019

Examining Interactions Between and Among Predictors of Net Ecosystem Exchange: A Machine Learning Approach in a Semi-arid Landscape.

Sci Rep 2019 Feb 18;9(1):2222. Epub 2019 Feb 18.

Department of Geosciences, Boise State University, Boise, ID, USA.

Net ecosystem exchange (NEE) is an essential climate indicator of the direction and magnitude of carbon dioxide (CO) transfer between land surfaces and the atmosphere. Improved estimates of NEE can serve to better constrain spatiotemporal characteristics of terrestrial carbon fluxes, improve verification of land models, and advance monitoring of Earth's terrestrial ecosystems. Spatiotemporal NEE information developed by combining ground-based flux tower observations and spatiotemporal remote sensing datasets are of potential value in benchmarking land models. Read More

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http://dx.doi.org/10.1038/s41598-019-38639-yDOI Listing
February 2019

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics.

Mol Metab 2019 Jan 30. Epub 2019 Jan 30.

Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. Electronic address:

Objective: Shotgun lipidomics enables an extensive analysis of lipids from tissues and fluids. Each specimen requires appropriate extraction and processing procedures to ensure good coverage and reproducible quantification of the lipidome. Adipose tissue (AT) has become a research focus with regard to its involvement in obesity-related pathologies. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.01.009DOI Listing
January 2019