74,895 results match your criteria ADVANCE for Nurses[Journal]


An optimized analytical method for cellular targeted quantification of primary metabolites in tricarboxylic acid cycle and glycolysis using gas chromatography-tandem mass spectrometry and its application in three kinds of hepatic cell lines.

J Pharm Biomed Anal 2019 Apr 12;171:171-179. Epub 2019 Apr 12.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Energy synthesis in aerobic organisms relies on two major metabolic pathways, i.e. tricarboxylic acid (TCA) cycle and glycolysis, the metabolites of which are highly affected by many diseases. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07317085193009
Publisher Site
http://dx.doi.org/10.1016/j.jpba.2019.04.022DOI Listing
April 2019
1 Read

How should end-of-life advance care planning discussions be conducted according to patients and informal carers? A qualitative review of reviews.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Division of Nursing, Midwifery & Social Work, School of Health Sciences, University of Manchester, Oxford Road, Manchester M13 9PL; National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) Greater Manchester.

Context: The goal of advance care planning (ACP) is to help ensure that the care people receive during periods of serious illness is consistent with their preferences and values. There is a lack of clear understanding about how patients and their informal carers feel ACP discussions should be conducted.

Objectives: To synthesise literature reviews pertaining to patients' and informal carers' perspectives on ACP discussions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpainsymman.2019.04.013DOI Listing

Extent and Determinants of Terminally Ill Cancer Patients' Concordance between Preferred and Received Life-Sustaining Treatment States: An Advance Care Planning Randomized Trial in Taiwan.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taiwan; Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung, Taiwan. Electronic address:

Purpose: To examine the effectiveness of an advance care planning (ACP) intervention in facilitating concordance between cancer patients' preferred and received life-sustaining treatment (LST) states and to explore modifiable factors facilitating or impeding such concordance.

Methods: Terminal cancer patients (N=460) were randomly assigned 1:1 to the experimental and control arms of a randomized clinical trial, with 430 deceased participants comprising the final sample. States of preferred LSTs (cardiopulmonary resuscitation, intensive care unit care, chest compression, intubation with mechanical ventilation, intravenous nutrition, and nasogastric tube feeding) and LSTs received in the last month were examined by hidden Markov modeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpainsymman.2019.04.010DOI Listing
April 2019
1 Read

The silent epidemic of chronic pain in older adults.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

Lipid Peroxidation Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA; Intramural Program of the National Institute on Alcohol Abuse and Alcoholism, USA. Electronic address:

Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are underrepresented in clinical trials testing treatments for chronic pain, the potential impacts of polypharmacy and frailty on reported outcomes and side effect profiles are largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pnpbp.2019.04.006DOI Listing
April 2019
2 Reads

Serum levels of immunoglobulin G and complement 3 differentiate non-diabetic renal disease from diabetic nephropathy in patients with type 2 diabetes mellitus.

Acta Diabetol 2019 Apr 19. Epub 2019 Apr 19.

Division of Nephrology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.

Aims: Heavy proteinuria caused by non-diabetic renal disease (NDRD) is common in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate specific predictors for NDRD in addition to traditional indicators in T2DM.

Methods: A total of 341 patients with T2DM who underwent renal biopsy were retrospectively included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00592-019-01339-0DOI Listing

Cardiovascular Risk Assessment Varies Widely by Calculator and Race/Ethnicity in a Majority Latinx Cohort Living with HIV.

J Immigr Minor Health 2019 Apr 19. Epub 2019 Apr 19.

Research to Advance Community Health (ReACH) Center, UT Health San Antonio, San Antonio, TX, USA.

Comparison of cardiovascular disease (CVD) risk calculators in Latinx majority populations living with HIV can assist clinicians in selecting a calculator and interpreting results. 10-year CVD risks were estimated for 652 patients seen ≥ 2 times over 12 months in a public clinic using three risk calculators: Atherosclerotic CVD risk Calculator (ASCVD), Framingham Risk Calculator (FRC), and Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) Calculator. Median estimated 10-year CVD risk in this population was highest using FRC (11%), followed by D:A:D (10%), and lowest with ASCVD (5%; p < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10903-019-00890-wDOI Listing

Process-Structure-Function in Association with the Main Bioactive of Black Rice Flour Sieving Fractions.

Foods 2019 Apr 18;8(4). Epub 2019 Apr 18.

Dunărea de Jos University of Galati, Faculty of Food Science and Engineering, Domnească Street 111, 800201 Galati, Romania.

The aim of this work was to advance knowledge on the potential use of black rice different sieving fractions for various functional applications, through proximate analysis, thermal degradation kinetics of phytochemical and characterization of the thermal behavior of the main proteins, from the perspectives of their use as a food ingredient. The results indicated that the thermal degradation of phytochemicals followed a first-order reaction kinetics for all the tested fractions. The temperature-dependent degradation was adequately modeled according to the Arrhenius equation. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/2304-8158/8/4/131
Publisher Site
http://dx.doi.org/10.3390/foods8040131DOI Listing
April 2019
1 Read

Connecting experts in the agricultural and meteorological sciences to advance knowledge of pest management in a changing climate.

Sci Total Environ 2019 Apr 10;673:694-698. Epub 2019 Apr 10.

Experimental Allergy Laboratory, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

There has been considerable progress in elucidating the physical aspects of climate change that directly impact food, feed, and fiber production. However, these impact assessments rarely account for climate induced changes associated with biological pests. The lack of collaboration between the pest management and climate science disciplines could be contributing to the problem. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2019.04.126DOI Listing
April 2019
1 Read

The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology, Barnard College-Columbia University, New York, NY 10027, United States of America. Electronic address:

Niemann-Pick type C (NP-C) disease is a rare and fatal neurodegenerative disease typified by aberrations in intracellular lipid transport. Cholesterol and other lipids accumulate in the late endosome/lysosome of all diseased cells thereby causing neuronal and visceral atrophy. A cure for NP-C remains elusive despite the extensive molecular advances emanating from the identification of the primary genetic defect in 1997. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2019.04.002DOI Listing
April 2019
1 Read

GalaxyRefine2: simultaneous refinement of inaccurate local regions and overall protein structure.

Nucleic Acids Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Chemistry, Seoul National University, Seoul 08826, Korea.

The 3D structure of a protein can be predicted from its amino acid sequence with high accuracy for a large fraction of cases because of the availability of large quantities of experimental data and the advance of computational algorithms. Recently, deep learning methods exploiting the coevolution information obtained by comparing related protein sequences have been successfully used to generate highly accurate model structures even in the absence of template structure information. However, structures predicted based on either template structures or related sequences require further improvement in regions for which information is missing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz288DOI Listing

Social Participation in the Daily Lives of Frail Older Adults: Types of Participation and Influencing Factors.

J Gerontol B Psychol Sci Soc Sci 2019 Apr 17. Epub 2019 Apr 17.

Vrije Universiteit Brussel, Brussels, Belgium.

Objectives: The advantages of social participation for older adults are well-established and have been adopted in aging policy frameworks. However, little is known about the social participation of frail older adults. This research examined the types of social interaction of very frail older adults and the factors influencing this participation. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/psychsocgerontology/advance-article
Publisher Site
http://dx.doi.org/10.1093/geronb/gbz045DOI Listing
April 2019
1 Read

Predicting the variable ocean carbon sink.

Sci Adv 2019 Apr 17;5(4):eaav6471. Epub 2019 Apr 17.

Max Planck Institute for Meteorology, Bundesstraße 53, 20146 Hamburg, Germany.

Strong decadal variations in the oceanic uptake of carbon dioxide (CO) observed over the past three decades challenge our ability to predict the strength of the ocean carbon sink. By assimilating atmospheric and oceanic observational data products into an Earth system model-based decadal prediction system, we can reproduce the observed variations of the ocean carbon uptake globally. We find that variations of the ocean CO uptake are predictable up to 2 years in advance globally, albeit there is evidence for a higher predictive skill up to 5 years regionally. Read More

View Article

Download full-text PDF

Source
http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
Publisher Site
http://dx.doi.org/10.1126/sciadv.aav6471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469943PMC
April 2019
1 Read

Imaging localized neuronal activity at fast time scales through biomechanics.

Sci Adv 2019 Apr 17;5(4):eaav3816. Epub 2019 Apr 17.

School of Biomedical Engineering and Imaging Sciences, Kings College London, London, UK.

Mapping neuronal activity noninvasively is a key requirement for in vivo human neuroscience. Traditional functional magnetic resonance (MR) imaging, with a temporal response of seconds, cannot measure high-level cognitive processes evolving in tens of milliseconds. To advance neuroscience, imaging of fast neuronal processes is required. Read More

View Article

Download full-text PDF

Source
http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
Publisher Site
http://dx.doi.org/10.1126/sciadv.aav3816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469937PMC
April 2019
1 Read

Application of a Sensitive and Reproducible Label-Free Proteomic Approach to Explore the Proteome of Individual Meiotic-Phase Barley Anthers.

Front Plant Sci 2019 2;10:393. Epub 2019 Apr 2.

Cell and Molecular Sciences, The James Hutton Institute, Dundee, United Kingdom.

Meiosis is a highly dynamic and precisely regulated process of cell division, leading to the production of haploid gametes from one diploid parental cell. In the crop plant barley (), male meiosis occurs in anthers, in specialized cells called meiocytes. Barley meiotic tissue is scarce and not easily accessible, making meiosis study a challenging task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpls.2019.00393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454111PMC

Infection in a C3HeB/FeJ Mouse Model.

Front Microbiol 2019 3;10:693. Epub 2019 Apr 3.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Infections caused by complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated and associated with relatively poor outcome. Identification of new animal models that demonstrate a similar pulmonary pathology as humans infected with MAC has the potential to significantly advance our understanding of nontuberculosis mycobacteria (NTM) pathogenesis as well as provide a tractable model for screening candidate compounds for therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456659PMC

Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI).

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose: The objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers.

Methods: Prospective pilot case series of individuals with and without dry eye (DE). Two sequential images were obtained with the TFI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313379DOI Listing

Central Processing of Itch in the Midbrain Reward Center.

Neuron 2019 Apr 8. Epub 2019 Apr 8.

Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai 201210, China. Electronic address:

Itch is an aversive sensation that evokes a desire to scratch. Paradoxically, scratching the itch also produces a hedonic experience. The specific brain circuits processing these different aspects of itch, however, remain elusive. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08966273193029
Publisher Site
http://dx.doi.org/10.1016/j.neuron.2019.03.030DOI Listing
April 2019
5 Reads

Sustaining pneumococcal vaccination after transitioning from Gavi support: a modelling and cost-effectiveness study in Kenya.

Lancet Glob Health 2019 May;7(5):e644-e654

Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: In 2009, Gavi, the World Bank, and donors launched the pneumococcal Advance Market Commitment, which helped countries access more affordable pneumococcal vaccines. As many low-income countries begin to reach the threshold at which countries transition from Gavi support to self-financing (3-year average gross national income per capita of US$1580), they will need to consider whether to continue pneumococcal conjugate vaccine (PCV) use at full cost or to discontinue PCV in their childhood immunisation programmes. Using Kenya as a case study, we assessed the incremental cost-effectiveness of continuing PCV use. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S2214109X183056
Publisher Site
http://dx.doi.org/10.1016/S2214-109X(18)30562-XDOI Listing
May 2019
1 Read

Understanding patient engagement in health system decision-making: a co-designed scoping review.

Syst Rev 2019 Apr 18;8(1):97. Epub 2019 Apr 18.

The Department Community Health Sciences, Teaching Research and Wellness Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.

Background: With healthcare striving to shift to a more person-centered delivery model, patient and family involvement must have a bigger role in shaping this. While many initiatives involving patients and family members focus on self-care, a broader understanding of patient participation is necessary. Ensuring a viable and sustainable critical number of qualified patients and family members to support this shift will be of utmost importance. Read More

View Article

Download full-text PDF

Source
https://systematicreviewsjournal.biomedcentral.com/articles/
Publisher Site
http://dx.doi.org/10.1186/s13643-019-0994-8DOI Listing
April 2019
1 Read

An In Silico Model for Predicting Drug-Induced Hepatotoxicity.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

As one of the leading causes of drug failure in clinical trials, drug-induced liver injury (DILI) seriously impeded the development of new drugs. Assessing the DILI risk of drug candidates in advance has been considered as an effective strategy to decrease the rate of attrition in drug discovery. Recently, there have been continuous attempts in the prediction of DILI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20081897DOI Listing

Physics-based spectral compensation algorithm for X-ray CT with primary modulator.

Phys Med Biol 2019 Apr 18. Epub 2019 Apr 18.

Advanced Therapies, Siemens Healthineers, Forchheim, GERMANY.

X-ray computed tomography (CT) scatter correction using primary modulator has been continuously developed over the past years, with progress in improving the performance of scatter correction. In this work, we further advance the primary modulator technique towards practical applications where the spectral nonuniformity caused by the modulator continues to be a challenging problem. A physics-based spectral compensation algorithm is proposed to adaptively correct for the spectral nonuniformity, and hence to reduce the resultant ring artifacts on reconstructed CT images. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6560/ab1ad0
Publisher Site
http://dx.doi.org/10.1088/1361-6560/ab1ad0DOI Listing
April 2019
1 Read

Individual, clinical and system factors associated with the place of death: A linked national database study.

PLoS One 2019 18;14(4):e0215566. Epub 2019 Apr 18.

Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Background: Many middle- and high-income countries face the challenge of meeting preferences for home deaths. A better understanding of associated factors could support the design and implementation of policies and practices to enable dying at home. This study aims to identify factors associated with the place of death in Singapore, a country with a strong sense of filial piety. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215566PLOS

The effects of in-vitro pH decrease on the gametogenesis of the red tree coral, Primnoa pacifica.

PLoS One 2019 18;14(4):e0203976. Epub 2019 Apr 18.

Alaska Fisheries Science Center, National Marine Fisheries Services, National Oceanic and Atmospheric Administration, Juneau, Alaska, United States of America.

Primnoa pacifica is the most ecologically important coral species in the North Pacific Ocean and provides important habitat for commercially important fish and invertebrates. Ocean acidification (OA) is more rapidly increasing in high-latitude seas because anthropogenic CO2 uptake is greater in these regions. This is due to the solubility of CO2 in cold water and the reduced buffering capacity and low alkalinity of colder waters. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203976PLOS
April 2019
1 Read

The role of the transition clinic from pediatric to adult inflammatory bowel disease care.

Curr Opin Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: The transition of patients from pediatric to adult centered care represents not only the means to transfer medical care to a group of providers who specialize in adult care but also is part of the process of the transfer of healthcare responsibility from the family to a patient. The intent of this review is to provide a summary of some of the important studies published in the past 2 years that advance this knowledge.

Recent Findings: Progress has been made in the recognition of the process of transition, including developing tools to assess transition readiness, improving routes of communication along with patient education. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00001574-900000000-9920
Publisher Site
http://dx.doi.org/10.1097/MOG.0000000000000535DOI Listing
April 2019
1 Read

SQUIRE-EDU (Standards for QUality Improvement Reporting Excellence in Education): Publication Guidelines for Educational Improvement.

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

G. Ogrinc is senior associate dean for medical education, and professor of medicine, the Dartmouth Institute, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. G.E. Armstrong is associate professor, University of Colorado College of Nursing, Aurora, Colorado. M.A. Dolansky is associate professor, Case Western Reserve University, Frances Payne Bolton School of Nursing, and Department of Veterans Affairs Louis Stokes Medical Center, Cleveland, Ohio. M.K .Singh is assistant dean, Health Systems Science, and associate professor of medicine, Case Western Reserve University School of Medicine and Department of Veterans Affairs Louis Stokes Medical Center, Cleveland, Ohio. L. Davies is associate professor, Section of Otolaryngology-Head & Neck Surgery, and the Dartmouth Institute, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; and associate professor, Department of Veterans Affairs Medical Center, White River Junction, Vermont.

The SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence) guidelines were published in 2015 to increase the completeness, precision, and transparency of published reports about efforts to improve the safety, value, and quality of health care. The principles and methods applied in work to improve health care are often applied in educational improvement as well. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACM.0000000000002750DOI Listing
April 2019
1 Read

The Eighteen of 1918-1919: Black Nurses and the Great Flu Pandemic in the United States.

Am J Public Health 2019 Apr 18:e1-e8. Epub 2019 Apr 18.

At the time of the study, Marian Moser Jones and Matilda Saines were with the University of Maryland School of Public Health, College Park.

This article examines the role of Black American nurses during the 1918-1919 influenza pandemic and the aftermath of World War I. The pandemic caused at least 50 million deaths worldwide and 675 000 in the United States. It occurred during a period of pervasive segregation and racial violence, in which Black Americans were routinely denied access to health, educational, and political institutions. Read More

View Article

Download full-text PDF

Source
https://ajph.aphapublications.org/doi/10.2105/AJPH.2019.3050
Publisher Site
http://dx.doi.org/10.2105/AJPH.2019.305003DOI Listing
April 2019
1 Read

Ru-Based Catechothiolate Complexes Bearing an Unsaturated NHC Ligand: Effective Cross-Metathesis Catalysts for Synthesis of ( Z)-α,β-Unsaturated Esters, Carboxylic Acids, and Primary, Secondary, and Weinreb Amides.

J Am Chem Soc 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.

Despite notable progress, olefin metathesis methods for preparation of ( Z)-α,β-unsaturated carbonyl compounds, applicable to the synthesis of a large variety of bioactive molecules, remain scarce. Especially desirable are transformations that can be promoted by ruthenium-based catalysts, as such entities would allow direct access to carboxylic esters and amides, or acids (in contrast to molybdenum- or tungsten-based alkylidenes). Here, we detail how, based on the mechanistic insight obtained through computational and experimental studies, a readily accessible ruthenium catechothiolate complex was found that may be used to generate many α,β-unsaturated carbonyl compounds in up to 81% yield and ≥98:2 Z/ E ratio. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.9b02318DOI Listing

Characterizing Properties and Environmental Behaviors of Dissolved Organic Matter Using Two-Dimensional Correlation Spectroscopic Analysis.

Environ Sci Technol 2019 Apr 18. Epub 2019 Apr 18.

Dissolved organic matter (DOM) exists ubiquitously in environments and plays critical roles in pollutant mitigation, transformation and organic geochemical cycling. Understanding its properties and environmental behaviors is critically important to develop water treatment processes and environmental remediation strategies. Generalized two-dimensional correlation spectroscopy (2DCOS), which has numerous advantages including enhancing spectral resolution and discerning specific order of structural change under an external perturbation, could be used as a powerful tool to interpret a wide range of spectroscopic signatures relating to DOM. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.est.9b01103
Publisher Site
http://dx.doi.org/10.1021/acs.est.9b01103DOI Listing
April 2019
1 Read

Changing the Question.

Authors:
Daniel Brudney

Hastings Cent Rep 2019 Mar;49(2):9-16

Jack, who is seventy-five years old, is in the hospital with a terminal condition that has undermined his cognitive faculties. He has left no advance directive and has never had a conversation in which he made his treatment wishes remotely clear. Yet now, a treatment decision must be made, and in modern American medicine, the treatment decision for Jack is supposed to be made by a surrogate decision-maker, who is supposed to use a decision-making standard known as "substituted judgment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hast.988DOI Listing

[Recent Advances in Immunotherapy for Acute Myeloid Leukemia --Review].

Authors:
Bin Xu Yi Xiao

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):633-636

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China E-mail:

Currently, the traditional chemotherapeutic drugs for acute myeloid leukemia (AML) showed significant curative efficacy, including the improving long-term prognosis and the life quality of the patients, however the traditional chemotherapeuatic drugs showed the some limitatious in the aspects of enhancing the complete remission rate of newly diagnosed AML patients, overcoming the relapse after remission,as well as the primary and secondary drug-resstance to chemotherapeutics. In order to improve the long-term prognisis of patients, the immuno therapy will the best choice for these patients. This review sammarizes the main current advance of immunotherapy of AML at home and abroad, such as antibody-drug conjugate(ADC), bispecific T cell engager (BiTE), chimeric type of antigen receptor T cell (CAR-T) therapy, checkpoint inhibitors; dendritic cell vaccination and peptide vaccines; natural killer cell (NK) therapy and so on. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19746/j.cnki.issn1009-2137.2019.02.053DOI Listing
April 2019
2 Reads

Actions developed by the Brazilian Physiological Society to promote women's participation in science.

Adv Physiol Educ 2019 Jun;43(2):199-206

Instituto do Coração, University of São Paulo , São Paulo , Brazil.

Here we described two activities related to Women in Science: one main conference and one symposium, both developed during the Annual Congress of the Brazilian Physiological Society, which were held within the XXXIII Annual Meeting of the Federation of Brazilian Experimental Biology Societies, from September 3-6, 2018, in Campos do Jordão (SP/Brazil). This conference and the symposium were among the most popular activities of the congress. This is important because the activities addressed important issues, including the fact that only 29% of the worlds' researchers are women, and women have difficulty progressing in a scientific career. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/advan.00216.2018DOI Listing

Using active pedagogies to advance learning for lifestyle medicine: an approach for medical students.

Adv Physiol Educ 2019 Jun;43(2):191-195

Department of Medical Education, University of Central Florida College of Medicine , Orlando, Florida.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/advan.00195.2018DOI Listing

How is implementation research applied to advance health in low-income and middle-income countries?

BMJ Glob Health 2019 7;4(2):e001257. Epub 2019 Mar 7.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

This paper examines the characteristics of implementation research (IR) efforts in low-income and middle-income countries (LMICs) by describing how key IR principles and concepts have been used in published health research in LMICs between 1998 and 2016, with focus on how to better apply these principles and concepts to support large-scale impact of health interventions in LMICs. There is a stark discrepancy between principles of IR and what has been published. Most IR studies have been conducted under conditions where the researchers have considerable influence over implementation and with extra resources, rather than in 'real world' conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgh-2018-001257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441291PMC

Targeted therapy in cervical cancer.

ESMO Open 2018 7;3(Suppl 1):e000462. Epub 2019 Feb 7.

Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Cervical cancer continues to be a common cancer in women worldwide, especially in less developed regions where advanced stage presentations are common. Addition of bevacizumab to cytotoxic chemotherapy has been the only notable recent advance in the treatment of recurrent and metastatic cervical cancer. Outcomes in patients with locally advanced disease have also plateaued after meaningful gains were achieved with concomitant chemoradiation treatment. Read More

View Article

Download full-text PDF

Source
http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2018-000
Publisher Site
http://dx.doi.org/10.1136/esmoopen-2018-000462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438352PMC
February 2019
2 Reads

Symmetry breaking and the turn-on fluorescence of small, highly strained carbon nanohoops.

Chem Sci 2019 Apr 25;10(13):3786-3790. Epub 2019 Feb 25.

Department of Chemistry & Biochemistry , Materials Science Institute , University of Oregon , Eugene , Oregon 97403 , USA . Email:

[]Cycloparaphenylenes, or "carbon nanohoops," are unique conjugated macrocycles with radially oriented π-systems similar to those in carbon nanotubes. The centrosymmetric nature and conformational rigidity of these molecules lead to unusual size-dependent photophysical characteristics. To investigate these effects further and expand the family of possible structures, a new class of related carbon nanohoops with broken symmetry is disclosed. Read More

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C9SC00169G
Publisher Site
http://dx.doi.org/10.1039/c9sc00169gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446961PMC
April 2019
1 Read

Spatially resolved mapping of phase transitions in liquid-crystalline materials by X-ray birefringence imaging.

Chem Sci 2019 Mar 2;10(10):3005-3011. Epub 2019 Jan 2.

School of Chemistry , Cardiff University , Park Place , Cardiff CF10 3AT , Wales , UK . Email:

The X-ray Birefringence Imaging (XBI) technique, first reported in 2014, is a sensitive method for spatially resolved mapping of the local orientational properties of anisotropic materials. We report the first application of the XBI technique to characterize molecular orientational ordering in a liquid crystalline material, demonstrating significant potential for exploiting XBI measurements to advance structural understanding of liquid crystal phases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8sc05285aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430193PMC

Assisted reproductive technologies in genus.

Reprod Med Biol 2019 Apr 11;18(2):121-127. Epub 2018 Oct 11.

Graduate School of Veterinary Medicine and Life Science, Graduate School Nippon Veterinary and Life Science University Musashino, Tokyo Japan.

Background: genus is one of the experimental animals showing unique characteristics, and some species have been used as various research models. In order to advance the utilization of genus, the development of assisted reproductive technologies (ARTs) is a key point. This review introduces recent progress in the development of ARTs for genus, especially (Japanese field vole). Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/rmb2.12244
Publisher Site
http://dx.doi.org/10.1002/rmb2.12244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452009PMC
April 2019
1 Read

Relaxation training for management of paediatric headache: A rapid review.

Paediatr Child Health 2019 May 7;24(2):103-114. Epub 2019 Feb 7.

Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta.

The objective of this review was to assess the evidence on relaxation training for management of paediatric headaches. Our methodology was a rapid review of English-language peer reviewed published literature focused on studies evaluating relaxation training as a primary or adjunct management option for headache in a paediatric population (0 to 18 years of age). Seven studies involving 571 children were included in the review. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/pch/article/24/2/103/5308619
Publisher Site
http://dx.doi.org/10.1093/pch/pxy157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462122PMC
May 2019
1 Read

Clinical Impact of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Japanese Population in the ADVANCE Registry.

Circ J 2019 Apr 18. Epub 2019 Apr 18.

Wakayama Medical University.

Background: Coronary computed tomography angiography (cCTA)-derived fractional flow reserve (FFR) is a promising diagnostic method for the evaluation of coronary artery disease (CAD). However, clinical data regarding FFRin Japan are scarce, so we assessed the clinical impact of using FFRin a Japanese population.Methods and Results:The ADVANCE registry is an international prospective FFRregistry of patients suspected of CAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1253/circj.CJ-18-1269DOI Listing

DNA-encoded bispecific T cell engagers and antibodies present long-term antitumor activity.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, USA.

Specific antibody therapy, including mAbs and bispecific T cell engagers (BiTEs), are important new tools for cancer immunotherapy. However, these approaches are slow to develop and may be limited in their production, thus restricting the patients who can access these treatments. BiTEs exhibit a particularly short half-life and difficult production. Read More

View Article

Download full-text PDF

Source
https://insight.jci.org/articles/view/126086
Publisher Site
http://dx.doi.org/10.1172/jci.insight.126086DOI Listing
April 2019
2 Reads

Planning After Stroke Survival: Advance Care Planning in the Stroke Clinic.

J Am Heart Assoc 2019 May;8(9):e011317

2 Harborview Medical Center University of Washington Seattle WA.

Background Stroke survivors have high rates of mortality and recurrent stroke. Stroke patients are often unable to participate in decision making, highlighting the need for advance care planning ( ACP ) in poststroke care. We sought to better understand experiences and perceptions around stroke risk and ACP in our stroke clinic. Read More

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/JAHA.118.011317
Publisher Site
http://dx.doi.org/10.1161/JAHA.118.011317DOI Listing
May 2019
2 Reads

The Effect of the Mixing Region Geometry and Collector Distance on Microbubble Formation using a Capillary Embedded Microfluidic Device coupled with AC-DC Electric Fields.

Langmuir 2019 Apr 18. Epub 2019 Apr 18.

In this work we report a significant advance in the preparation of monodisperse microbubbles using a combination of microfluidic and electric field technologies. Microbubbles have been employed in various fields such as biomedical engineering, water purification and food engineering. Many techniques have been investigated for their preparation. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.langmuir.8b03677
Publisher Site
http://dx.doi.org/10.1021/acs.langmuir.8b03677DOI Listing
April 2019
1 Read

Comparison of Place-versus-Pitch Mismatch between a Perimodiolar and Lateral Wall Cochlear Implant Electrode Array in Patients with Single-Sided Deafness and a Cochlear Implant.

Audiol Neurootol 2019 Apr 17;24(1):38-48. Epub 2019 Apr 17.

Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: In electric-acoustic pitch matching experiments in patients with single-sided deafness and a cochlear implant, the observed "mismatch" between perceived pitch and predicted pitch, based on the amended Greenwood frequency map, ranges from -1 to -2 octaves. It is unknown if and how this mismatch differs for perimodiolar versus lateral wall electrode arrays.

Objectives: We aimed to investigate if the type of electrode array design is of influence on the electric-acoustic pitch match. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499154DOI Listing

Tailor-made branch reconstruction by intracranial to intracranial bypass during clipping surgery for middle cerebral artery aneurysms.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: In clipping surgery, it is advantageous to dissect an adhered artery from the aneurysmal dome to achieve complete clipping. Bypass surgery is useful to reconstruct an adhered artery when dissection of the artery is technically difficult or risky. Here, we report the effectiveness of tailor-made intracranial (IC)-IC bypass to reconstruct an adhered artery in clipping surgery for middle cerebral artery (MCA) aneurysms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.04.074DOI Listing
April 2019
1 Read

Characteristics of children and adolescents at the Switzerland-wide first ambulatory interdisciplinary pain clinic at the University Children's Hospital Basel - a retrospective study.

Swiss Med Wkly 2019 Apr 17;149:w20073. Epub 2019 Apr 17.

Pain Therapy Unit, Department for Anaesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Switzerland.

Aims Of The Study: Given the long history of underestimating chronic pain in children and adolescents, we lack valid data on its assessment and treatment. The psychological and economic burden for patients, their families and society is substantial. The aim of this study was to assess patient characteristics of the first ambulatory interdisciplinary clinic for children and adolescents with chronic pain in Switzerland and compare them with data from other international centres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2019.20073DOI Listing

Stigma and discrimination related to gender identity and vulnerability to HIV/AIDS among transgender women: a systematic review.

Cad Saude Publica 2019 8;35(4):e00112718. Epub 2019 Apr 8.

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brasil.

HIV prevalence among transgender women is disproportional when compared to the general population in various countries. Stigma and discrimination based on gender identity have frequently been associated with vulnerability to HIV/AIDS. The objective was to conduct a systematic literature review to analyze the relationship between stigma and discrimination related to gender identity in transgender women and vulnerability to HIV/AIDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0102-311X00112718DOI Listing

Characterizing the Biomedical Data-Sharing Landscape.

J Law Med Ethics 2019 Mar;47(1):21-30

Angela G. Villanueva, M.P.H., is a Research Associate at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Robert Cook-Deegan, M.D., is a Professor in the School for the Future of Innovation in Society at Arizona State University. Barbara A. Koenig, Ph.D., is Professor of Bioethics and Medical Anthropology, based at the Institute for Health & Aging, University of California, San Francisco. Patricia A. Deverka, M.D., M.S., M.B.E., is Director, Value Evidence and Outcomes at Geisinger National Precision Health, where she focuses on demonstrating the value of genomic sequencing for health systems and policy-makers.Erika Versalovic is a Ph.D. student in the philosophy department at the University of Washington and a neuroethics fellow with the Center for Neurotechnology in Seattle, WA. Amy L. McGuire, J.D., Ph.D., is the Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Mary A. Majumder, J.D., Ph.D., is an Associate Professor of Medicine at the Center for Medical Ethics and Health Policy, Baylor College of Medicine.

Advances in technologies and biomedical informatics have expanded capacity to generate and share biomedical data. With a lens on genomic data, we present a typology characterizing the data-sharing landscape in biomedical research to advance understanding of the key stakeholders and existing data-sharing practices. The typology highlights the diversity of data-sharing efforts and facilitators and reveals how novel data-sharing efforts are challenging existing norms regarding the role of individuals whom the data describe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1073110519840481DOI Listing

Cerebral venous thrombosis in adults.

Vasa 2019 Apr 17:1-10. Epub 2019 Apr 17.

1 Vivantes Klinikum im Friedrichshain, Berlin, Germany.

Thromboses of cerebral veins and/or sinuses (CVT) encompass a clinically rather heterogenous, relatively rare entity, which is nonetheless an important cause of stroke in the young. While until the mid of the last century the prognosis of CVT was thought to be poor or even fatal in the majority of cases, the advance and wider use of modern imaging technology since the early 1980s, together with the results of registries and population-based studies, revealed that CVT is more frequent and less life-threatening than previously assumed. However, because headache is frequently the only symptom, many oligosymptomatic cases might be overlooked. Read More

View Article

Download full-text PDF

Source
https://econtent.hogrefe.com/doi/10.1024/0301-1526/a000788
Publisher Site
http://dx.doi.org/10.1024/0301-1526/a000788DOI Listing
April 2019
2 Reads

Influence of Surface Charge on the Phytotoxicity, Transformation and Translocation of CeO2 Nanoparticles in Cucumber Plants.

ACS Appl Mater Interfaces 2019 Apr 17. Epub 2019 Apr 17.

The physiochemical properties of nanoparticles (NPs), including surface charge, will affect their uptake, transformation, translocation, and final fate in the environment. In the present study, we compared the phytoxoxicity and transport of nano-CeO2 (nCeO2) functionalized with positively charged (Cs-nCeO2) and negatively charged (PAA-nCeO2) coatings. Cucumber seedlings were hydroponically exposed to 0~1000 mg/L of Cs-nCeO2 and PAA-nCeO2 for 14 days and the contents, translocation, distribution and transformation of Ce in plants were analyzed using inductively coupled plasma mass spectrometry (ICP-MS), micro X-ray fluorescence (μ-XRF), and X-ray absorption near-edge spectroscopy (XANES), respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b01627DOI Listing

Inflammation in Mild Cognitive Impairment due to Parkinson's disease, Lewy Body disease and Alzheimer's disease.

Int J Geriatr Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Institute of Neuroscience, Newcastle upon Tyne, United Kingdom.

Background: Inflammation appears to play a role in the progression of neurodegenerative diseases. However, little is known about inflammation during early stages of cognitive decline or whether this differs in different disease groups. We sought to investigate this by assessing the inflammatory profile in patients with Parkinson's disease with the early stages of cognitive impairment (PD-MCI), patients with prodromal Alzheimer's disease (MCI-AD), prodromal Lewy Body disease (MCI-LB) and controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gps.5124DOI Listing
April 2019
3 Reads