72,602 results match your criteria ADVANCE for NPs & PAs [Journal]


Insufficient sleep and fitness to drive in shift workers: a systematic literature review protocol.

Inj Prev 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Health Sciences, Western University, London, Ontario, Canada.

Background: The majority of shift workers experience insufficient sleep as a result of their employment. Insufficient sleep is associated with impaired neurocognitive functioning, affecting key skills required for driving, resulting in shift workers experiencing a disproportionate burden of RTC injuries and fatalities. Yet, to our knowledge, no systematic literature review (SLR) exists to critically appraise and synthesise evidence on the determinants of fitness to drive (assessed on-road) and driving performance (assessed in a driving simulator) in shift workers with insufficient sleep. Read More

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December 2018

Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats.

Neuropharmacology 2018 Dec 13. Epub 2018 Dec 13.

Pharmacology and Therapeutics, NCBES Galway Neuroscience Centre, National University of Ireland, Galway, Ireland. Electronic address:

Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial μ-opioid receptor (MOR) agonist and κ-opioid receptor (KOR) antagonist, and samidorphan (SAM), a potent MOR antagonist, as an adjuvant treatment in patients with major depressive disorder (MDD). To advance understanding of the mechanism of action underlying this combination, we examined BUP, SAM and their combination in a series of rat behavioural assays. We examined effects on locomotor activity in Sprague Dawley (SD) rats over an extended period of time in a home-cage tracking system, and behavioural despair (immobility) in the forced swim test (FST), a commonly-used test to study antidepressants, in SD and Wistar-Kyoto (WKY) rats. Read More

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December 2018

Carl August Krauspe (1895-1983)-Founder and honorary member of the "European Society of Pathology" and "politically reliable" National Socialist.

Pathol Res Pract 2018 Dec 5. Epub 2018 Dec 5.

Institute for History, Theory and Ethics of Medicine, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Germany. Electronic address:

The name of the Hamburg pathologist Carl August Krauspe (1895-1983) is closely linked to the history of the "European Society of Pathology" (ESP) and the "German Pathological Society" (DGP): He was one of the founding fathers of the ESP, became its vice president, and was appointed an honorary member in 1983. From 1953-1962 he also served as secretary of the DGP and editor of the association's proceedings. In 1962/63 he finally held the chairmanship of the DGP. Read More

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December 2018

Palliative Care Consultation Before Left Ventricular Assist Device Implantation.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Adult Palliative Care Service, Department of Medicine, Columbia University Medical Center, New York, NY, USA.

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December 2018

To explore of the prevalence and outcomes of advance care planning for patients with left ventricular assist devices: a review.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

DMedEth RN SFHEA Senior Lecturer University of Birmingham.

Aims And Objectives: To explore of the prevalence and outcomes of advance care planning for patients with left ventricular assist devices: a review.

Background: End-stage heart failure is associated with significant symptom burden at rest. Left ventricular assist devices are not curative nevertheless they alleviate symptoms and prolong survival. Read More

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December 2018

How Do Family Strengths-Oriented Therapeutic Conversations (FAM-SOTC) Advance Psychiatric Nursing Practice?

J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.

Psychiatric Clinical Nurse Specialist, Landspitali University Hospital, Landspitali-The National University Hospital in Iceland, Child and Adolescent Psychiatric Division, Reykjavik, Iceland.

Purpose: Family nursing interventions, focusing on therapeutic conversations, have been found to benefit primary caregivers dealing with chronic and acute illnesses. Less is known, however, about the benefit of these interventions for partner caregivers. The aims of this study were to develop and test the Family Strengths-Oriented Therapeutic Conversation (FAM-SOTC) intervention for partner caregivers of young individuals with eating disorders (EDs). Read More

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December 2018
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Achieving proficiency in rigid bronchoscopy-a study in manikins.

Ir J Med Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Anaesthesia, The Rotunda Hospital, Parnell Square, Dublin, Ireland.

Background: Rigid bronchoscopy may be used to relieve acute airway obstruction following induction of anaesthesia and is a recommended option for management of the difficult airway. The ability of anaesthetists to perform rigid bronchoscopy has not been reported. We sought to explore the acquisition of procedural skill in rigid bronchoscopy by anaesthesiologists in a manikin. Read More

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December 2018

Effects of positive and negative expectations on human pain perception engage separate but interrelated and dependently regulated cerebral mechanisms.

J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan.

Expectations substantially influence pain perception, but the relationship between positive and negative expectations remains unclear. Recent evidence indicates that the integration between pain-related expectations and prediction errors is crucial for pain perception, which suggests that aversive prediction error-associated regions, such as the anterior insular cortex (aIC) and rostral anterior cingulate cortex (rACC), may play a pivotal role in expectation-induced pain modulation and help to delineate the relationship between positive and negative expectations. In a stimulus expectancy paradigm combining fMRI in healthy volunteers of both sexes, we found that, although positive and negative expectations respectively engaged the right aIC and right rACC to modulate pain, their associated activations and pain rating changes were significantly correlated. Read More

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December 2018

The Hispanic Community Health Study/Study of Latinos Community and Surrounding Areas Study: sample, design, and procedures.

Ann Epidemiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Family Medicine and Public Health, School of Medicine, University of California, San Diego, San Diego, CA.

Purpose: We describe the sample, design, and procedures for the Community and Surrounding Areas Study (CASAS), an ancillary to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The aim of SOL CASAS was to test an ecological model of macro- and micro-neighborhood environment factors, intermediate behavioral (physical activity) and psychosocial (e.g. Read More

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November 2018
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Oral medicine: Today's future can become tomorrow's reality.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Nov 22;126(5):409-414. Epub 2018 Aug 22.

Professor and Head, Oral Medicine, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; Co-chair, Head & Neck Cancer/Oral Oncology Program, Neag Comprehensive Cancer Center, UConn Health Farmington, CT, USA.

There have been strategic clinical, educational, and research advances in the field of Oral Medicine over the past several decades. In many cases, Oral Medicine experts are contributing the lead role in these advances nationally and internationally. In addition, American Board of Dental Specialty recognition of Oral Medicine as a specialty in 2015 has positioned Oral Medicine professionals to substantively enhance the delivery of oral health care to medically complex patients as well. Read More

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November 2018

Effects of a single transient transfection of Ten-eleven translocation 1 catalytic domain on hepatocellular carcinoma.

PLoS One 2018 14;13(12):e0207139. Epub 2018 Dec 14.

College of Pharmacy, Nanchang University, Nanchang, Jiangxi, P.R. China.

Tumor suppressor genes (TSGs), including Ten-eleven translocation 1 (TET1), are hypermethylated in hepatocellular carcinoma (HCC). TET1 catalytic domain (TET1-CD) induces genome-wide DNA demethylation to activate TSGs, but so far, anticancer effects of TET1-CD are unclear. Here we showed that after HCC cells were transiently transfected with TET1-CD, the methylation levels of TSGs, namely APC, p16, RASSF1A, SOCS1 and TET1, were distinctly reduced, and their mRNA levels were significantly increased and HCC cells proliferation, migration and invasion were suppressed, but the methylation and mRNA levels of oncogenes, namely C-myc, Bmi1, EMS1, Kpna2 and c-fos, were not significantly change. Read More

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December 2018
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The Suitability of Grounded Theory Research for Correctional Nursing.

J Forensic Nurs 2018 Dec 13. Epub 2018 Dec 13.

Author Affiliations: Faculty of Nursing, University of Calgary.

The tension between custody and caring is particular to correctional nursing practice, including issues such as the correctional priorities of safety and security that often dominate nursing practice. The evidence that should underlie correctional nursing practice is regrettably sparse. There are two reasons a grounded theory (GT) approach is paramount for building foundational knowledge to advance correctional nursing practice. Read More

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December 2018

Irradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature.

Org Lett 2018 Dec 14. Epub 2018 Dec 14.

Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.

A cobaloxime-catalyzed photochemical synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives. Read More

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December 2018

Quality control and stability of ketamine, remifentanil and sufentanil syringes in a pediatric operating theater.

Paediatr Anaesth 2018 Dec 14. Epub 2018 Dec 14.

CHU Lille, Institut de Pharmacie, F-59000, Lille, France.

Background: Transforming a drug from its commercial form into a ready-to-use drug is common practice, especially in pediatrics. However, the risk of compounding error is real and data on drug stability in practise are not always available.

Aims: To assess, in real conditions, both the error rate and stability of 3 drugs: ketamine, remifentanil and sufentanil. Read More

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December 2018

Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling.

Compr Physiol 2018 Dec 13;9(1):375-411. Epub 2018 Dec 13.

Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Epidemiological studies demonstrate disparities between men and women in cardiovascular disease prevalence, clinical symptoms, treatments, and outcomes. Enrollment of women in clinical trials is lower than men, and experimental studies investigating molecular mechanisms and efficacy of certain therapeutics in cardiovascular disease have been primarily conducted in male animals. These practices bias data interpretation and limit the implication of research findings in female clinical populations. Read More

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December 2018
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Study Enrollment when "Pre-Consent" is Utilized for a Randomized Trial of Two Treatments for Acute Agitation in the Emergency Department.

Acad Emerg Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Emergency Medicine, University of Arkansas for Medical Sciences, Little Rock, AR.

Background: Acute agitation in the ED represents a danger to both patients and their caregivers. Medication is often needed, and few high-quality randomized trials have evaluated the optimal drugs for this vulnerable population. In the United States, as of 2017, randomized trials of drugs cannot be conducted under Waiver of Consent (46 CFR 45. Read More

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December 2018

Trait-based ecology of terrestrial arthropods.

Biol Rev Camb Philos Soc 2018 Dec 13. Epub 2018 Dec 13.

Department of Zoology, University of Oxford, Oxford, OX1 3PS, U.K.

In focusing on how organisms' generalizable functional properties (traits) interact mechanistically with environments across spatial scales and levels of biological organization, trait-based approaches provide a powerful framework for attaining synthesis, generality and prediction. Trait-based research has considerably improved understanding of the assembly, structure and functioning of plant communities. Further advances in ecology may be achieved by exploring the trait-environment relationships of non-sessile, heterotrophic organisms such as terrestrial arthropods, which are geographically ubiquitous, ecologically diverse, and often important functional components of ecosystems. Read More

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December 2018

Peer-driven family support services in the context of first-episode psychosis: Participant perceptions from a Canadian early intervention programme.

Early Interv Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Douglas Mental Health University Institute, Montreal, Canada.

Aim: This paper aims to advance our understanding of the experience of participating in peer support groups for family members of persons with psychosis and to expand the scant body of literature on peer support in the context of early intervention services for psychosis. Such an examination is relevant because the implementation and uptake of family-focused interventions remain inconsistent in early intervention services, despite their proven benefits.

Methods: To enable family caregivers to support one another, a family peer support project was initiated at an early intervention service for psychosis in Montreal, Canada. Read More

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December 2018

Squeezing-enhanced heterodyne detection of 10  Hz atto-Watt optical signals.

Authors:
Boya Xie Sheng Feng

Opt Lett 2018 Dec;43(24):6073-6076

A phase-sensitive (PS) heterodyne detector is intrinsically resistant to classical noises and useful in measurement of low-frequency signals below the shot noise. Despite the existence of image band vacuum, we show that the quantum-noise power level of this heterodyne detector sensing a coherent signal is exactly one light quantum per measurement time, i.e. Read More

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December 2018

Adolescent Depression and Substance Use: the Protective Role of Prosocial Peer Behavior.

J Abnorm Child Psychol 2018 Dec 14. Epub 2018 Dec 14.

University of Tennessee, Center for Behavioral Health Research, Henson Hall, 213, Knoxville, TN, 37996-3332, USA.

Adolescents with depression disorders have higher rates of substance use. In order to advance contextually relevant mental health interventions, basic research is needed to test social ecological mechanisms hypothesized to influence adolescent depression and substance use. Accordingly, we conducted growth curve modeling with a sample of 248 urban adolescents to determine if depression's effect on substance use was dependent upon peer network health (sum of peer risk and protective behaviors) and activity space risk (likelihood of high-risk behaviors at routine locations). Read More

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December 2018

The mysterious long-range transport of giant mineral dust particles.

Sci Adv 2018 Dec 12;4(12):eaau2768. Epub 2018 Dec 12.

NIOZ-Royal Netherlands Institute for Sea Research, Department of Ocean Systems, and Utrecht University, Texel, Netherlands.

Giant mineral dust particles (>75 μm in diameter) found far from their source have long puzzled scientists. These wind-blown particles affect the atmosphere's radiation balance, clouds, and the ocean carbon cycle but are generally ignored in models. Here, we report new observations of individual giant Saharan dust particles of up to 450 μm in diameter sampled in air over the Atlantic Ocean at 2400 and 3500 km from the west African coast. Read More

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December 2018

Integrating design thinking with sustainability science: a Research through Design approach.

Sustain Sci 2018 20;13(6):1565-1587. Epub 2018 Aug 20.

1School of Earth and Environmental Science, The University of Queensland, Brisbane, QLD Australia.

Design disciplines have a long history of creating well-integrated solutions to challenges which are complex, uncertain and contested by multiple stakeholders. Society faces similar challenges in implementing the Sustainable Development Goals, so design methods hold much potential. While principles of good design are well established, there has been limited integration of design thinking with sustainability science. Read More

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Framing natural assets for advancing sustainability research: translating different perspectives into actions.

Sustain Sci 2018 17;13(6):1519-1531. Epub 2018 Jul 17.

10Basque Centre for Climate Change, University of the Basque Country (UPV-EHU), Sede Building 1, 1st Floor, Scientific Campus, Leioa, 48940 Bilbao, Spain.

Sustainability is a key challenge for humanity in the context of complex and unprecedented global changes. Future Earth, an international research initiative aiming to advance global sustainability science, has recently launched knowledge-action networks (KANs) as mechanisms for delivering its research strategy. The research initiative is currently developing a KAN on "natural assets" to facilitate and enable action-oriented research and synthesis towards natural assets sustainability. Read More

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July 2018
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Mapping interactions between the sustainable development goals: lessons learned and ways forward.

Sustain Sci 2018 13;13(6):1489-1503. Epub 2018 Jul 13.

10CSIRO Land and Water, Canberra, Australia.

Pursuing integrated research and decision-making to advance action on the sustainable development goals (SDGs) fundamentally depends on understanding interactions between the SDGs, both negative ones ("trade-offs") and positive ones ("co-benefits"). This quest, triggered by the 2030 Agenda, has however pointed to a gap in current research and policy analysis regarding how to think systematically about interactions across the SDGs. This paper synthesizes experiences and insights from the application of a new conceptual framework for mapping and assessing SDG interactions using a defined typology and characterization approach. Read More

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July 2018
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Fresh-blood-free diet for rearing malaria mosquito vectors.

Sci Rep 2018 Dec 13;8(1):17807. Epub 2018 Dec 13.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisboa, Portugal.

Mosquito breeding depends on the supply of fresh vertebrate blood, a major bottleneck for large-scale production of Anopheles spp. Feeding alternatives to fresh blood are thus a priority for research, outdoor large-cage trials and control interventions. Several artificial meal compositions were tested and Anopheles oogenesis, egg laying and development into the next generation of adult mosquitoes were followed. Read More

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December 2018

Reporting guidelines: doing better for readers.

Authors:
David Moher

BMC Med 2018 Dec 14;16(1):233. Epub 2018 Dec 14.

Centre for Journalology, Clinical Epidemiology Program, The Ottawa Hospital Research Institute, The Ottawa Hospital - General Campus, 501 Smyth Rd, Room L1288, Ottawa, ON, K1H 8L6, Canada.

There is clear guidance on the responsibilities of editors to ensure that the research they publish is of the highest possible quality. Poor reporting is unethical and directly impacts patient care. Reporting guidelines are a relatively recent development to help improve the accuracy, clarity, and transparency of biomedical publications. Read More

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December 2018

Consequences of community water fluoridation cessation for Medicaid-eligible children and adolescents in Juneau, Alaska.

BMC Oral Health 2018 Dec 13;18(1):215. Epub 2018 Dec 13.

Public Health Programs, School of Health Sciences, College of Health Sciences, Walden University, 100 Washington Ave. South, Suite 900, Minneapolis, MN, 55401, USA.

Background: The general aim of this research was to determine whether cessation of community water fluoridation (CWF) increased oral health disparities, as measured by dental caries procedures and restoration costs for children and adolescents.

Methods: The analysis was based on all Medicaid dental claims records of 0- to 18-year-old patients residing in zip code 99801 (Juneau, Alaska) during an optimal CWF year (2003, n = 853) compared to all claims for the same age group from 2012 (n = 1052), five years after cessation of CWF. A bivariate analysis (Mann-Whitney U test) of the mean number of caries procedures performed per client was conducted in the study groups under both independent CWF conditions. Read More

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December 2018

Formulating productive marketing communications strategy: a major health system's experience.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):926. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Healthcare establishments serve as key community resources, bringing into locales a wealth of resources aimed at enhancing and improving health and wellness. Without effective communications, current and prospective patients will remain unaware of available offerings, foiling opportunities for mutually beneficial exchange. Today, healthcare organizations engage audiences by selecting from among the components of the marketing communications mix, but this wasn't always the case. Read More

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December 2018

From Research-to-Practice: An Adaptation and Dissemination of the COMPASS Program for Home Care Workers.

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

Department of Family Medicine, Oregon Health & Science University, Portland, OR 97239, USA.

The COMmunity of Practice And Safety Support (COMPASS) program was developed to prevent injuries and advance the health and well-being of home care workers. The program integrates elements of peer-led social support groups with scripted team-based programs to help workers learn together, solve problems, set goals, make changes, and enrich their supportive professional network. After a successful pilot study and randomized controlled trial, COMPASS was adapted for the Oregon Home Care Commission's training system for statewide dissemination. Read More

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December 2018

A new scoring model predicting macroscopic vascular invasion of early-intermediate hepatocellular carcinoma.

Medicine (Baltimore) 2018 Dec;97(49):e13536

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University.

Macroscopic vascular invasion cannot be properly predicted in advance in hepatocellular carcinoma patients based on clinical characteristics and imaging features.To develop a predictive scoring model of macroscopic vascular invasion in hepatocellular carcinoma patients after transcatheter arterial chemoembolization combined with radiofrequency ablation based on specific laboratory and tumor indicators.A predictive scoring model, which estimates the incidence of macroscopic vascular invasion at 1-year follow-up, was constructed based on a derivation cohort of 324 patients with hepatocellular carcinoma; a validation cohort of 120 patients was prospectively included. Read More

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December 2018

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.

Nucleic Acids Res 2018 Dec 14. Epub 2018 Dec 14.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA.

Small interfering RNA (siRNA)-based therapies are proving to be efficient for treating liver-associated disorders. However, extra-hepatic delivery remains challenging, limiting therapeutic siRNA utility. We synthesized a panel of fifteen lipid-conjugated siRNAs and systematically evaluated the impact of conjugate on siRNA tissue distribution and efficacy. Read More

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December 2018

Using a glucose meter to quantitatively detect disease biomarkers through a universal nanozyme integrated lateral fluidic sensing platform.

Biosens Bioelectron 2018 Nov 23;126:690-696. Epub 2018 Nov 23.

Nanobioengineering/Bioelectronics Laboratory, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL 33174, United States. Electronic address:

Along with the advance in medical research, more biomarkers emerge as useful indicators for both disease and health index. However, majority of them have no practical or economic testing methods available yet, or rely on high-costing methods such as Enzyme-Linked Immuno-Sorbent Assay (ELISA), High-Performance Liquid Chromatography (HPLC), Mass Spectrum, and immunohistochemistry (IHC). In this article, we develop a universal nanozyme integrated testing platform for biological molecules that incorporates the electrochemical measurement of glucose with lateral flow immunostrip (LFS) for target analytes. Read More

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November 2018
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Exploring the potential role of mesocorticolimbic circuitry in motivation for and adherence to chronic pain self-management interventions.

Neurosci Biobehav Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, 5510 Nathan Shock Drive, Suite 101, Baltimore, MD, USA.

Adherence to pain self-management strategies is associated with favorable psychobehavioral outcomes among individuals with chronic pain. Substantive adherence to treatments teaching these adaptive skills proves challenging, resulting in poor individual and societal outcomes. Evidence demonstrates motivation for behavior change as a key predictor of treatment adherence. Read More

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December 2018

Advance Care Planning Among Patients With Advanced Cancer.

J Oncol Pract 2018 Dec 13:JOP1800044. Epub 2018 Dec 13.

The Pennsylvania State University, College of Medicine, Hershey, PA.

Purpose:: Advance directives (AD) have been heralded as vehicles to promote patient autonomy and have been decried as ineffective. Efforts to improve advance care planning (ACP) and AD documents are wide ranging but have not been prospectively studied.

Materials And Methods:: In an institutional review board-approved, single-blind, randomized, controlled trial, we compared an interactive, educational ACP decision aid to standard ACP among patients with advanced cancer. Read More

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December 2018

Nanoscale Core-Shell Hyperbolic Structures for Ultralow Threshold Laser Action: An Efficient Platform for the Enhancement of Optical Manipulation.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Plasmonic material has been emerged with multi-functionalities for its remarkable tailoring light emission, reshaping density of states (DOS) and focusing subwavelength light. However, restricted by its propagation loss and narrowband resonance in nature, it is a challenge issue for plasmonic material to provide a broadband DOS to advance its application. Here, we develop a novel nanoscale core-shell hyperbolic structure that possesses a remarkably coupling effect inside the multishell nanoscale composite owing to a higher DOS and longer time of collective oscillations of the electrons than the plasmonic-based pure metal nanoparticles. Read More

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December 2018

Identification of FT family genes that respond to photoperiod, temperature and genotype in relation to flowering in cassava (Manihot esculenta, Crantz).

Plant Reprod 2018 Dec 12. Epub 2018 Dec 12.

Section of Soil and Crop Sciences, School of Integrative Plant Science, Cornell University, Ithaca, NY, USA.

Cassava is a starch-storing root crop that is an important source of dietary energy in tropical regions of the world. Genetic improvement of cassava by breeding is hindered by late flowering and sparse flower production in lines that are needed as parents. To advance understanding of regulatory mechanisms in cassava, this work sought to identify and characterize homologs of the FLOWERING LOCUS T (FT) gene. Read More

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December 2018

Cancer Gene Discovery Utilizing Sleeping Beauty Transposon Mutagenesis.

Methods Mol Biol 2019 ;1907:161-170

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Transposable elements are DNA sequences with the ability to move from one genomic location to another. The movement of class II transposable elements has been functionally harnessed and separated into two distinct DNA transposon components: the terminal inverted repeat sequences that flank genetic cargo to be mobilized and a transposase enzyme capable of recognizing the terminal inverted repeat sequences and catalyzing the transposition reaction. In particular, the Sleeping Beauty (SB) system was the first successful demonstration of transposon-based gene transfer in vertebrate species. Read More

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January 2019

Intelligent Wearable Occupational Health Safety Assurance System of Power Operation.

J Med Syst 2018 Dec 12;43(1):16. Epub 2018 Dec 12.

State Grid Sichuan Electric Power Research Institute, Chengdu, China.

To improve the capacity of emergency control over on-site operation risk and effectively guarantee safety of operators in a complicated environment, a wearable safety assurance system framework for power operation is proposed. The framework centres on a wearable information processing gateway for single man and provides standardized access for vital signs monitoring, human-machine interaction and other equipment in a form of wireless ad hoc network. Using wearable vital signs monitoring equipment, the physiological parameters such as heart rate, body temperature and blood pressure can be monitored in real time. Read More

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December 2018

[Patient advanced directives from the perspective of surgery patients-new aspects and aims : Living wills of patients before planned surgery].

Chirurg 2018 Dec 12. Epub 2018 Dec 12.

Klinik für Allgemein- und Visceralchirurgie, Städtisches Klinikum Karlsruhe, Moltkestraße 90, 76133, Karlsruhe, Deutschland.

Background: Patient advance directives and other forms of precautionary medical provisions have arisen from patients' determination to influence and decide about medical treatment even in extreme situations. Although this topic is very present in the media, clinical experience indicates that the majority of patients are not yet aware of this subject. This current investigation aimed to collect data about the familiarity and degree of distribution of patient medical advance directives. Read More

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December 2018

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET.

Chem Sci 2018 Nov 11;9(42):8046-8055. Epub 2018 Sep 11.

NanoBioPhotonics , Institute for Integrative Biology of the Cell (I2BC) , Université Paris-Saclay , Université Paris-Sud , CNRS , CEA , Orsay , France . Email: ; https://www.nanofret.com.

MicroRNAs (miRNAs) play an important role in cellular functions and in the development and progression of cancer. Precise quantification of endogenous miRNAs from different clinical patient and control samples combined with a one-to-one comparison to standard technologies is a challenging but necessary endeavor that is largely neglected by many emerging fluorescence technologies. Here, we present a simple, precise, sensitive, and specific ratiometric assay for absolute quantification of miRNAs. Read More

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November 2018

An Automated Image Analysis Pipeline Enables Genetic Studies of Shoot and Root Morphology in Carrot ( L.).

Front Plant Sci 2018 27;9:1703. Epub 2018 Nov 27.

Department of Botany, University of Wisconsin-Madison, Madison, WI, United States.

Carrot is a globally important crop, yet efficient and accurate methods for quantifying its most important agronomic traits are lacking. To address this problem, we developed an automated image analysis platform that extracts components of size and shape for carrot shoots and roots, which are necessary to advance carrot breeding and genetics. This method reliably measured variation in shoot size and shape, petiole number, petiole length, and petiole width as evidenced by high correlations with hundreds of manual measurements. Read More

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November 2018

Structural basis of coreceptor recognition by HIV-1 envelope spike.

Nature 2018 Dec 12. Epub 2018 Dec 12.

Division of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

HIV-1 envelope glycoprotein (Env), which consists of trimeric (gp160) cleaved to (gp120 and gp41), interacts with the primary receptor CD4 and a coreceptor (such as chemokine receptor CCR5) to fuse viral and target-cell membranes. The gp120-coreceptor interaction has previously been proposed as the most crucial trigger for unleashing the fusogenic potential of gp41. Here we report a cryo-electron microscopy structure of a full-length gp120 in complex with soluble CD4 and unmodified human CCR5, at 3. Read More

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December 2018

In vivo confocal microscopy classification in the diagnosis of meibomian gland dysfunction.

Eye (Lond) 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, DHU Sight Restore, INSERM-DHOS CIC, Paris, France.

Aim: Meibomian gland dysfunction (MGD) is one of the most common disorders in ophthalmology. The aim of this study was to evaluate the use of this in vivo confocal microscopy (IVCM)-MGD description to classify patients affected by clinical MGD and measure the correlation with standard clinical criteria and subjective symptoms.

Methods: One hundred eyes of 100 patients suffering from MGD and 15 eyes of normal subjects were included. Read More

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December 2018

Comparative transcriptome analysis revealed the improved β-carotene production in Sporidiobolus pararoseus yellow mutant MuY9.

J Gen Appl Microbiol 2018 Dec 13. Epub 2018 Dec 13.

College of Land and Environment, Shenyang Agricultural University.

Carotenoids are ubiquitous constituents of living organisms. These structurally diverse pigments have received considerable attention due to their biotechnological applications and potential beneficial effects on human health. In this study, we characterized an over-producing β-carotene mutant of Sporidiobolus pararoseus, obtained by ultraviolet mutagenesis, named MuY9. Read More

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December 2018

A novel 6D-approach to radically transform undergraduate medical education: preliminary reflections from MBRU.

BMC Med Educ 2018 Dec 12;18(1):304. Epub 2018 Dec 12.

Department of Family and Community Medicine, University of Toronto, Toronto, Canada.

Background: Designers of undergraduate medical education (UME) need to address the exponentially expanding volume and variability of scientific knowledge, where by didactic teaching techniques need to be augmented by innovative student-centric pedagogical strategies and implementation of milieus, where information, communication and technology-enabled tools are seamlessly integrated, and lifelong information gathering, assimilation, integration and implementation is the ultimate goal. In UME, the basic sciences provide a solid scaffold allowing students to develop their personal critical decisional framework as well as define the understanding of normal human physiology, pivotal for the identification, categorization and management of pathophysiology. However, most medical schools confine themselves to "stagnant curricula", with the implementation of traditional "teacher centered" pedagogical techniques in the dissemination of the courses pertaining to basic sciences in UME. Read More

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December 2018

The Effect of Acute Exercise on Encoding and Consolidation of Long-Term Memory.

J Sport Exerc Psychol 2018 Dec 12:1-7. Epub 2018 Dec 12.

1 University of North Carolina Greensboro.

Evidence supports that acute exercise benefits long-term memory. However, it is unclear whether these effects are due to benefits to encoding or consolidation. The purpose of this study was to more effectively isolate encoding and consolidation to advance our understanding of the specific nature of the effects of exercise on long-term memory. Read More

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December 2018

Of Parachutes and Participant Protection: Moving Beyond Quality to Advance Effective Research Ethics Oversight.

J Empir Res Hum Res Ethics 2018 Dec 12:1556264618812625. Epub 2018 Dec 12.

The following AEREO Consortium Members endorse this article in their individual capacities and not necessarily on behalf of any institutions of which they are a part: Angela Bain, Barbara E. Bierer, Justin Clapp, Anne K. Clark, Carl Coleman, Whitney Eriksen, Jonathan Green, Sarah Greene, Elisa A. Hurley, Steven Joffe, Susan Kornetsky, Lisa M. Lee, Lindsay McNair, Linda Parreco, Suzanne M. Rivera, Stephen Rosenfeld, Michele Russell-Einhorn, Megan Singleton, David H. Strauss, Emma Tumilty, and Tracy Ziolek. This publication represents the views of the authors and does not reflect the official position or policy of the National Cancer Institute, the National Institutes of Health, or the Department of Health and Human Services.

There are several reasons to believe that Institutional Review Boards (IRBs) and Human Research Protection Programs (HRPPs) contribute to ethical research and the protection of research participants, but there are also important reasons to interrogate this belief. Determining whether IRBs and HRPPs "work" requires empirical evaluation of whether and how well they actually achieve what they were designed to do. In other words, it is critical to examine their outcomes and not only their procedures and structures. Read More

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December 2018

Quasi-Experimental Evaluation of LifeCourse on Utilization and Patient and Caregiver Quality of Life and Experience.

Am J Hosp Palliat Care 2018 Dec 13:1049909118817740. Epub 2018 Dec 13.

4 Allina Health, Minneapolis, MN, USA.

Whole-person care is a new paradigm for serious illness, but few programs have been robustly studied. We sought to test the effect of LifeCourse (LC), a person-centered program for patients living with serious illness, on health-care utilization, care experience, and quality of life, employing a quasi-experimental design with a Usual Care (UC) comparison group. The study was conducted 2012 to 2017 at an upper-Midwest not-for-profit health-care system with outcomes measured every 3 months until the end of life. Read More

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December 2018
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Empowering Patients with Alzheimer's Disease To Avoid Unwanted Medical Care: A Look At The Dementia Care Triad.

Am J Alzheimers Dis Other Demen 2018 Dec 13:1533317518817614. Epub 2018 Dec 13.

4 New York State Department of Health, Albany, NY, USA.

Patients with Alzheimer's disease and other types of dementia with acute medical problems, who have lost capacity and are without advance directives, are at risk of being over treated inhospitals. To deal with this growing demographic and ethical crisis, patients with dementia need to plan for their future medical care while they have capacity to do so. This article will examine the role of each member of the dementia care triad and how to empower the patient to participate in planning future medical care. Read More

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December 2018