174 results match your criteria ADVANCE for NPs & PAs [Journal]


Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.

Drug Deliv Transl Res 2019 Feb 19. Epub 2019 Feb 19.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, JG56, Gainesville, FL, 32611, USA.

Strategies that control the differentiation of mesenchymal stem cells (MSC) and enable image-guided cell implantation and longitudinal monitoring could advance MSC-based therapies for bone defects and injuries. Here we demonstrate a multifunctional nanoparticle system that delivers resveratrol (RESV) intracellularly to improve osteogenesis and enables photoacoustic imaging of MSCs. RESV-loaded nanoparticles (RESV-NPs), formulated from poly (lactic-co-glycolic) acid and iron oxide, enhanced the stability of RESV by 18-fold and served as photoacoustic tomography (PAT) contrast for MSCs. Read More

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http://dx.doi.org/10.1007/s13346-019-00621-6DOI Listing
February 2019
1 Read

Liquid Crystalline Nanocolloids for the Storage of Electro-Optic Responsive Images.

ACS Appl Mater Interfaces 2019 Feb 15;11(8):8612-8624. Epub 2019 Feb 15.

Department of Chemistry , Tsinghua University , Beijing 100084 , China.

Liquid crystalline nanocolloids (LCNCs), which are nanostructured composites comprising nanoparticles (NPs) and a liquid crystal (LC) host, have attracted a great deal of attention because of their promising new fundamental physical behaviors and functional properties. Yet, it still remains a big challenge to pattern LCNCs into mesoscale-ordered structures due to the limited NP loading in the LC host. Here, we demonstrate LCNCs in the nematic phase with a high NP loading (∼42 wt %) by in situ co-functionalizing the NP with alkyl and mesogenic ligands. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b22636
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http://dx.doi.org/10.1021/acsami.8b22636DOI Listing
February 2019
6 Reads

Physiological and transcriptomic analyses reveal CuO nanoparticle inhibition of anabolic and catabolic activities of sulfate-reducing bacterium.

Environ Int 2019 Apr 30;125:65-74. Epub 2019 Jan 30.

Advanced Water Management Centre, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. Electronic address:

The widespread use of CuO nanoparticles (NPs) results in their continuous release into the environment, which could pose risks to public health and to microbial ecosystems. Following consumption, NPs will initially enter into sewer systems and interact with and potentially influence sewer microbial communities. An understanding of the response of microbes in sewers, particularly sulfate-reducing bacteria (SRB), to the CuO NPs induced stress is important as hydrogen sulfide produced by SRB can cause sewer corrosion and odour emissions. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.058DOI Listing
April 2019
1 Read

Surface Coverage-Regulated Cellular Interaction of Ultrasmall Luminescent Gold Nanoparticles.

ACS Nano 2019 Feb 4;13(2):1893-1899. Epub 2019 Feb 4.

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering , South China University of Technology , Guangzhou 510640 , China.

Investigations for accurately controlling the interaction between functional nanoparticles (NPs) and living cells set a long-thought benefit in nanomedicine and disease diagnostics. Here, we reveal a surface coverage-dependent cellular interaction by comparing the membrane binding and uptake of three ultrasmall luminescent gold NPs (AuNPs) with different surface coverages. Lower surface coverage leads to fast cellular interaction and strong membrane binding but low cellular uptake, whereas high surface coverage induces slow cellular interaction and low membrane binding but major cellular uptake. Read More

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http://dx.doi.org/10.1021/acsnano.8b08103DOI Listing
February 2019

Advances in Management of Psychosis in Neurodegenerative Diseases.

Curr Treat Options Neurol 2019 Jan 23;21(1). Epub 2019 Jan 23.

Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 901, New Haven, CT, 06511, USA.

Purpose Of The Review: Psychosis is broadly defined as a disengagement from reality. It describes syndromes that impair both thought content and thought process. Psychosis negatively impacts an individual's quality of life, in addition to the families caring for them. Read More

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http://dx.doi.org/10.1007/s11940-019-0545-6DOI Listing
January 2019
7 Reads

Impact of Surface-Engineered ZnO Nanoparticles on Protein Corona Configuration and Their Interactions With Biological System.

J Pharm Sci 2019 Jan 5. Epub 2019 Jan 5.

Biochemistry Laboratory, Animal Facility, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India. Electronic address:

In biological system, the interaction between nanoparticles (NPs) and serum biomolecules results in the formation of a dynamic corona of different affinities. The formed corona enriched with opsonin protein is recognized by macrophages and immune effector cells, resulting in rapid clearance with induced toxicity. Hence, to reduce corona genesis, surface-engineered ZnO (c-ZnO) NPs were in situ synthesized using a polyacrylamide-grafted guar gum (PAm-g-GG) polymer that provided surface neutrality to the NPs. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.12.021DOI Listing
January 2019
5 Reads
2.590 Impact Factor

Enhanced generation of reactive oxygen species and photocatalytic activity by Pt-based metallic nanostructures: the composition matters.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2018 Dec 30:1-13. Epub 2018 Dec 30.

a Key Laboratory for Micro-Nano Energy Storage and Conversion Materials of Henan Province , Institute of Surface Micro and Nano Materials; College of Advance Materials and Energy, Xuchang University , Xuchang , Henan , China.

The modification of semiconductor nanostructures with metallic nanocomponents can promote the separation of electron/hole from photoexited semiconductors by forming heterojunctions, thus exhibit enhanced photocatalytic activities and potential applications. In this study, Pt-based NPs, including Pt, PtCu, and PtCuCo are employed as model co-catalysts to comparatively study their capability to enhance the photocatalytic activity of TiO nanosheets. It was found that each of Pt, PtCu, and PtCuCo can greatly enhance the photocatalytic activity of TiO toward degradation of organic dyes. Read More

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http://dx.doi.org/10.1080/10590501.2018.1555317DOI Listing
December 2018
2 Reads

Controlled Synthesis of CuSe Nanoparticles as Near-Infrared Photothermal Agents and Irradiation Wavelength Dependence of Their Photothermal Conversion Efficiency.

Langmuir 2018 11 7;34(46):13905-13909. Epub 2018 Nov 7.

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics , South China Normal University , Guangzhou 510631 , China.

The ability to manipulate the near-infrared (NIR) localized surface plasmon resonance absorbance of copper chalcogenide materials is of utmost importance for applications such as photothermal therapy (PTT). In this work, we manipulate the NIR absorbance of copper selenide (CuSe) nanoparticles (NPs) by precisely controlling their size and composition. We also introduce a facile method for transferring ultrasmall hydrophobic CuSe NPs into aqueous solution. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b02133DOI Listing
November 2018
2 Reads

Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy.

Front Pharmacol 2018 15;9:1154. Epub 2018 Oct 15.

Lipoprotein Drug Delivery Research Laboratory, Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States.

Drug delivery to malignant tumors is limited by several factors, including off-target toxicities and suboptimal benefits to cancer patient. Major research efforts have been directed toward developing novel technologies involving nanoparticles (NPs) to overcome these challenges. Major obstacles, however, including, opsonization, transport across cancer cell membranes, multidrug-resistant proteins, and endosomal sequestration of the therapeutic agent continue to limit the efficiency of cancer chemotherapy. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01154
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http://dx.doi.org/10.3389/fphar.2018.01154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196266PMC
October 2018
43 Reads

Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection.

Biomaterials 2019 Jan 2;188:83-95. Epub 2018 Oct 2.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, PR China. Electronic address:

A near-infrared (NIR) light-triggerable thermo-sensitive hydrogel-based drug reservoir that can realize on-demand antibiotics release and hyperthermia-assisted bacterial inactivation was prepared to combat bacterial infection and promote wound healing. The drug reservoir was fabricated by mixing ciprofloxacin (Cip, a potent antibiotic)-loaded polydopamine (PDA) nanoparticles (NPs) and glycol chitosan (GC) to form an injectable hydrogel (PDA NP-Cip/GC hydrogel, abbreviated as Gel-Cip). On the one hand, the positive charge of GC and the adsorbability of PDA NPs made bacteria be readily trapped on the surface of Gel-Cip. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183069
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http://dx.doi.org/10.1016/j.biomaterials.2018.09.045DOI Listing
January 2019
7 Reads

Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle-Cell Membrane Interface.

Nano Lett 2018 Oct 18. Epub 2018 Oct 18.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, & CAS Center for Excellence in Nanoscience , National Center for Nanoscienceand Technology of China, and University of Chinese Academy of Sciences , Beijing 100190 , China.

The nanoparticle (nano)-cell membrane interface is one of the most important interactions determining the fate of nanoparticles (NPs), which can stimulate a series of biological events, allowing theranostic and other biomedical applications. So far, there remains a lack of knowledge about the mechanisms governing the nanoparticle-cell membrane interface, especially the impact of ligand exchange, in which molecules on the nanosurface become replaced with components of the cell membrane, resulting in unique interfacial phenomena. Herein, we describe a family of gold nanoparticles (AuNPs) of the same core size (∼13 nm core), modified with 12 different kinds of surface ligands, and the effects of their exchangeable ligands on both nanoparticle-supported lipid bilayers (SLBs) and nanoparticle-natural cell membrane interfaces. Read More

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http://dx.doi.org/10.1021/acs.nanolett.8b02638DOI Listing
October 2018
20 Reads
13.592 Impact Factor

Sonication-enabled rapid production of stable liquid metal nanoparticles grafted with poly(1-octadecene-alt-maleic anhydride) in aqueous solutions.

Nanoscale 2018 Nov;10(42):19871-19878

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA.

Gallium-based liquid metals are attractive due to their unique combination of metallic and fluidic properties. Liquid metal nanoparticles (LM NPs), produced readily using sonication, find use in soft electronics, drug delivery, and other applications. However, LM NPs in aqueous solutions tend to oxidize and precipitate over time, which hinders their utility in systems that require long-term stability. Read More

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http://dx.doi.org/10.1039/c8nr05600eDOI Listing
November 2018
3 Reads
7.394 Impact Factor

Silica nanoparticles induce conformational changes of tau protein and oxidative stress and apoptosis in neuroblastoma cell line.

Int J Biol Macromol 2019 Mar 21;124:1312-1320. Epub 2018 Sep 21.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran. Electronic address:

The adverse effects of SiO NPs on the biological systems like nervous system have not been well explored. This study aimed to evaluate the toxicity of SiO NPs on the nervous system in vitro. Therefore, human tau protein and neuroblastoma cell line (SH-SY5Y) were used as targets. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.09.118DOI Listing
March 2019
4 Reads

Carbon nitrides and metal nanoparticles: from controlled synthesis to design principles for improved photocatalysis.

Chem Soc Rev 2018 Oct;47(20):7783-7817

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.

The use of sunlight to drive chemical reactions via photocatalysis is of paramount importance towards a sustainable future. Among several photocatalysts, earth-abundant polymeric carbon nitride (PCN, often wrongly named g-C3N4) has emerged as an attractive candidate due to its ability to absorb light efficiently in the visible and near-infrared ranges, chemical stability, non-toxicity, straightforward synthesis, and versatility as a platform for constructing hybrid materials. Especially, hybrids with metal nanoparticles offer the unique possibility of combining the catalytic, electronic, and optical properties of metal nanoparticles with PCN. Read More

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http://dx.doi.org/10.1039/c8cs00479jDOI Listing
October 2018
1 Read

Advancing the case for nurse practitioner-based models to accelerate scale-up of HIV pre-exposure prophylaxis.

J Clin Nurs 2019 Jan 11;28(1-2):351-361. Epub 2018 Oct 11.

University of Rochester, Rochester, New York.

Aims: To explore the factors that position nurse practitioners (NPs) to lead the implementation of HIV pre-exposure prophylaxis.

Background: The HIV epidemic represents a global health crisis. Reducing new HIV infections is a public health priority, especially for Black and Latino men who have sex with men (MSM). Read More

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http://doi.wiley.com/10.1111/jocn.14675
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http://dx.doi.org/10.1111/jocn.14675DOI Listing
January 2019
4 Reads

Aluminium oxide nanoparticles induce structural changes in tau and cytotoxicity of the neuroblastoma cell line.

Int J Biol Macromol 2018 Dec 1;120(Pt A):1140-1148. Epub 2018 Sep 1.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branches, Islamic Azad University (IAUPS), Tehran, Iran. Electronic address:

The application of nanomaterials in the healthy system may induce some neurodegenerative diseases initiated by tau folding and neuronal cell death. Herein, aluminium oxide nanoparticles (AlO NPs) were synthesized and characterized by XRD, TEM, DLS and zeta potential investigations. Afterwards, the interaction of AlO NPs with tau protein was investigated by fluorescence and CD spectroscopic methods. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.08.182DOI Listing
December 2018
14 Reads

Elucidating the interaction of Spathodea campanulata leaf extracts mediated potential bactericidal gold nanoparticles with human serum albumin: spectroscopic analysis.

J Biomol Struct Dyn 2018 Nov 18:1-14. Epub 2018 Nov 18.

a Department of Chemistry and Chemical Technology , Vidyasagar University , Midnapore , India.

Nanomaterials in different form have been thoroughly used in the area of pharmaceutics and medicine for drug delivery. The large scale of nanoparticles (NPs) synthesis from plant extract is much safe, cheap and eco-friendly. Here, we demonstrated a new, one-step, ultra-fast biosynthesis of gold nanoparticles (sc-AuNPs, 19. Read More

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https://www.tandfonline.com/doi/full/10.1080/07391102.2018.1
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http://dx.doi.org/10.1080/07391102.2018.1518157DOI Listing
November 2018
9 Reads

A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs.

Bioinorg Chem Appl 2018 1;2018:3569758. Epub 2018 Aug 1.

Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu, India.

The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties and photochemical, antifungal, high catalyst, and antimicrobial activities. Read More

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http://dx.doi.org/10.1155/2018/3569758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093006PMC
August 2018
5 Reads

Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity.

Nanomaterials (Basel) 2018 Aug 21;8(9). Epub 2018 Aug 21.

Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.

Nanoparticles (NPs) are currently used in diagnosis and treatment of many human diseases, including autoimmune diseases and cancer. However, cytotoxic effects of NPs on normal cells and living organs is a severe limiting factor that hinders their use in clinic. In addition, diversity of NPs and their physico-chemical properties, including particle size, shape, surface area, dispersity and protein corona effects are considered as key factors that have a crucial impact on their safe or toxicological behaviors. Read More

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http://dx.doi.org/10.3390/nano8090634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164883PMC
August 2018
28 Reads

Biophysical, docking, and cellular studies on the effects of cerium oxide nanoparticles on blood components: in vitro.

Int J Nanomedicine 2018 10;13:4575-4589. Epub 2018 Aug 10.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran,

Introduction: The application of nanoparticles (NPs) in medicine and biology has received great interest due to their novel features. However, their adverse effects on the biological system are not well understood.

Materials And Methods: This study aims to evaluate the effect of cerium oxide nanoparticles (CNPs) on conformational changes of human hemoglobin (HHb) and lymphocytes by different spectroscopic (intrinsic and synchronous fluorescence spectroscopy and far and near circular dichroism [CD] spectroscopy), docking and cellular (MTT and flow cytometry) investigations. Read More

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http://dx.doi.org/10.2147/IJN.S172162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091479PMC
September 2018
16 Reads

Stimulation of secondary metabolites by copper and gold nanoparticles in submerge adventitious root cultures of (Bert.).

IET Nanobiotechnol 2018 08;12(5):569-573

Center for Biotechnology and Microbiology, University of Swat, Swat 19200, Pakistan.

Nanotechnology is one of the advance technologies that almost found implications in every field of science. The importance is due to the unique properties of nanoparticles. In this study, bimetallic alloys of copper (Cu) and gold (Au) were tested in submerge root cultures of for production of biomass and secondary metabolites. Read More

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http://dx.doi.org/10.1049/iet-nbt.2017.0093DOI Listing
August 2018
3 Reads

Low Threshold Fabry-Pérot Mode Lasing from Lead Iodide Trapezoidal Nanoplatelets.

Small 2018 Aug 31;14(35):e1801938. Epub 2018 Jul 31.

Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, China.

Lead Iodide (PbI ) is a layered semiconductor with direct band gap holding great promises in green light emission and detection devices. Recently, PbI planar lasers are demonstrated using hexagonal whispering-gallery-mode microcavities, but the lasing threshold is quite high. In this work, lasing from vapor phase deposition derived PbI trapezoidal nanoplatelets (NPs) with threshold that is at least an order of magnitude lower than the previous value is reported. Read More

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http://dx.doi.org/10.1002/smll.201801938DOI Listing
August 2018
8 Reads
8.370 Impact Factor

Development of Nurse Practitioner Competencies for Advance Care Planning.

J Hosp Palliat Nurs 2018 Apr;20(2):166-171

Roberta Heale, DNP, NP-PHC, is associate professor, Laurentian University School of Nursing, Sudbury, Ontario, Canada. Lori Rietze, MSc, RN, is assistant professor, Laurentian University School of Nursing, Sudbury, Ontario, Canada. Laura Hill, MScN, NP, is nurse practitioner, Short Term Assessment & Treatment, Health Sciences North, Sudbury, Ontario, Canada. Stacey Roles, MScN, RN, is clinical nurse specialist trainer; consultant and diplomate, Academy of Cognitive Therapy; credentialed at the Canadian Association of Cognitive Behavioural Therapies; faculty, Psychiatry, Northern Ontario School of Medicine; and adjunct professor, School of Nursing, Laurentian University, Sudbury, Ontario, Canada.

This article describes the development of nurse practitioner (NP) competencies for advance care planning. Nurse practitioners are well positioned to implement advance care planning with their patients; however, very few patients have an advance care plan. A modified Delphi method was used to engage NPs in achieving consensus for advance care planning competencies. Read More

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http://dx.doi.org/10.1097/NJH.0000000000000425DOI Listing
April 2018
31 Reads

Titanium oxide nanoparticles fabrication, hemoglobin interaction, white blood cells cytotoxicity, and antibacterial studies.

J Biomol Struct Dyn 2018 Jul 25:1-38. Epub 2018 Jul 25.

d Department of Biology, Faculty of Food Industry and Agriculture , Standard Research Institute (SRI) , Karaj , I.R. Iran.

This study is focused on the fabrication and characterization of titanium oxide (TiO) NPs. Afterwards; the interaction of TiO NPs with human hemoglobin (Hb) was investigated by FTIR spectroscopy, fluorescence spectroscopy, and molecular docking studies. Also, the cytotoxic effect of fabricated TiO NPs against human white blood cells (WBCs) was considered by MTT assay. Read More

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http://dx.doi.org/10.1080/07391102.2018.1499555DOI Listing
July 2018
3 Reads

Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma.

Int J Nanomedicine 2018 10;13:3975-3987. Epub 2018 Jul 10.

Department of Pharmaceutics, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China,

Background: To date, the rapid clearance from ocular surface has been a huge obstacle for using eye drops to treat glaucoma, since it has led to the short preocular residence time and low bioavailability.

Methods: The novel nanoparticles (NPs) were designed for topical ophthalmic controlled drug delivery system through intercalating the BH into the interlayer gallery of Na-montmorillonite (Na+Mt) and then further enchasing chitosan nanoparticles. The resulting nanoparticles had a positive charge (+29±0. Read More

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http://dx.doi.org/10.2147/IJN.S162306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045908PMC
August 2018
21 Reads

Cobalt oxide nanoparticles mediate tau denaturation and cytotoxicity against PC-12 cell line.

Int J Biol Macromol 2018 Oct 11;118(Pt B):1763-1772. Epub 2018 Jul 11.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University of Tehran (IAUPS), Iran. Electronic address:

It has not been well explored how NPs may induce some adverse effects on the biological systems. In this research, the interaction of cobalt oxide NPs (CoO NPs) with tau protein and PC-12 cell line, as nervous system models, was investigated with several approaches including fluorescence spectroscopy, CD spectroscopy, docking study, MTT, LDH, AO/EB dual staining, and flow cytometry assays. Fluorescence investigation displayed that CoO NPs spontaneously mediate the formation of a static complex with tau protein through hydrogen bonds and van der Waals forces. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183305
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http://dx.doi.org/10.1016/j.ijbiomac.2018.07.024DOI Listing
October 2018
15 Reads

Interaction of silica nanoparticles with tau proteins and PC12 cells: Colloidal stability, thermodynamic, docking, and cellular studies.

Int J Biol Macromol 2018 Oct 19;118(Pt B):1963-1973. Epub 2018 Jul 19.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran. Electronic address:

Study on the side effects of the nanoparticles (NPs) can provide useful information regarding their biological and medical applications. Herein, the colloidal stability of the silicon dioxide NPs (SiO NPs) in the absence and presence of tau was investigated by TEM and DLS techniques. Afterwards, the thermodynamic parameters of interaction between SiO NPs and tau were determined by fluorescence spectroscopy and docking studies. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.07.041DOI Listing
October 2018
3 Reads

Heme degradation and iron release of hemoglobin and oxidative stress of lymphocyte cells in the presence of silica nanoparticles.

Int J Biol Macromol 2018 Oct 27;118(Pt A):800-807. Epub 2018 Jun 27.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran. Electronic address:

Silica nanoparticles (SiO NPs) have been widely used in the medical and food sciences. However, their toxic effects against bio-macromolecules and cells are not well understood. The present study was aimed to investigate the adverse effects of fabricated SiO NPs on the human hemoglobin (Hb) by FTIR, CD, fluorescence, and UV-vis spectroscopic techniques. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.06.128DOI Listing
October 2018
5 Reads

Maximizing Aggregation of Organic Fluorophores to Prolong Fluorescence Lifetime for Two-Photon Fluorescence Lifetime Imaging.

Adv Healthc Mater 2018 Aug 28;7(15):e1800299. Epub 2018 May 28.

Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.

Two-photon fluorescence lifetime imaging (TP-FLIM) not only permits imaging deep inside the tissues with precise spatial manipulation but also circumvents tissue autofluorescence, holding tremendous promise in molecular imaging. However, the serious lack of suitable contrast agents with long fluorescence lifetime and efficient two-photon absorption (TPA) greatly limits the advance of TP-FLIM. This study reports a simple approach to fabricate water-soluble organic semiconducting nanoparticles [thioxanthone (TXO) NPs] with ultralong fluorescence lifetime and efficient TPA for in vivo TP-FLIM. Read More

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http://dx.doi.org/10.1002/adhm.201800299DOI Listing
August 2018
51 Reads

Nurse practitioners' completion of Physician Orders for Scope of Treatment forms in West Virginia: A secondary analysis of 12 months of data from the state registry.

J Am Assoc Nurse Pract 2018 Jan;30(1):10-16

School of Medicine, West Virginia University, Morgantown, West Virginia.

Background And Purpose: Advanced care planning documents, such as the Physician Orders for Life-Sustaining Treatment (POLST), require authorized medical provider signatures; only recently have nurse practitioners (NPs) been authorized to sign these forms. Recent legislation in West Virginia (WV) granting NPs signatory authority on POLST forms and the creation of a statewide registry provides an opportunity to examine the completion rates. The aim of this study was to investigate how recent legislation allowing NPs signatory authority for POLST forms has affected POLST completion. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000012DOI Listing
January 2018
2 Reads

Advance care planning and anticipatory decision making in patients with Alzheimer disease.

Nurse Pract 2018 Jun;43(6):23-31

Jason T. Slyer is a clinical assistant professor at Pace University, College of Health Professions, New York, N.Y., and an NP at Matrix Medical Network, New York, N.Y. Ella Archibald is a family NP at Hospital for Special Surgery, New York, N.Y. Fernea Moyo is an NP at New York Presbyterian Hospital, New York, N.Y. Marie Truglio-Londrigan is a professor at Pace University College of Health Professions, Lienhard School of Nursing, New York, N.Y.

Early advance care planning and anticipatory decision making in the Alzheimer disease (AD) trajectory is a strategy NPs can incorporate to improve managing uncertainty around common decisions. This article explores decisions patients and caregivers face along the AD trajectory and provides resources for patients, caregivers, and NPs. Read More

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http://dx.doi.org/10.1097/01.NPR.0000532763.68509.e4DOI Listing
June 2018
15 Reads

Advance and Application of DNA-functionalized Nanoparticles.

Curr Med Chem 2018 Apr 30. Epub 2018 Apr 30.

Jiangsu Key Laboratory of Medical Optics, Chinese Academy of Sciences, Suzhou. China.

DNA-functionalized nanoparticle (DfNP) technology, the integration of DNA with nanotechnology, has emerged over recent decades as a promising biofunctionalization tool in the light of biotechnological approaches. The development of DfNPs has exhibited significant potential for several biological and biomedical applications. In this review, we focus on the mechanism of a series of DNA-NP nanocomposites and highlight the superstructures of DNA-based NPs. Read More

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http://dx.doi.org/10.2174/0929867325666180501103620DOI Listing
April 2018
9 Reads

Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles.

BMC Cancer 2018 04 23;18(1):457. Epub 2018 Apr 23.

Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA.

Background: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not significantly improve overall survival rate. It is highly desirable to advance the therapeutic efficacy of chemotherapeutic drugs by targeting their delivery and increasing accumulation at the tumor site. Read More

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http://dx.doi.org/10.1186/s12885-018-4393-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914049PMC
April 2018
10 Reads

Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-HO Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay.

Anal Chem 2018 05 17;90(9):5930-5937. Epub 2018 Apr 17.

Department of Chemistry and Biochemistry , University of Texas at El Paso , 500 West University Avenue , El Paso , Texas 79968 , United States.

The exploration of new physical and chemical properties of materials and their innovative application in different fields are of great importance to advance analytical chemistry, material science, and other important fields. Herein, we, for the first time, discovered the photothermal effect of an iron oxide nanoparticles (NPs)-mediated TMB (3,3',5,5'-tetramethylbenzidine)-HO colorimetric system, and applied it toward the development of a new NP-mediated photothermal immunoassay platform for visual quantitative biomolecule detection using a thermometer as the signal reader. Using a sandwich-type proof-of-concept immunoassay, we found that the charge transfer complex of the iron oxide NPs-mediated one-electron oxidation product of TMB (oxidized TMB) exhibited not only color changes, but also a strong near-infrared (NIR) laser-driven photothermal effect. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177380PMC
May 2018
5 Reads
1 Citation
5.640 Impact Factor

Nanoparticle assisted laser desorption/ionization mass spectrometry for small molecule analytes.

Mikrochim Acta 2018 03 1;185(3):200. Epub 2018 Mar 1.

Department of Chemistry, Assuit University, Assuit, 71515, Egypt.

Nanoparticle assisted laser desorption/ionization mass spectrometry (NPs-ALDI-MS) shows remarkable characteristics and has a promising future in terms of real sample analysis. The incorporation of NPs can advance several methods including surface assisted LDI-MS, and surface enhanced LDI-MS. These methods have advanced the detection of many thermally labile and nonvolatile biomolecules. Read More

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http://dx.doi.org/10.1007/s00604-018-2687-8DOI Listing
March 2018
2 Reads

mediated green synthesis of biocompatible gold nanoparticles simultaneously possessing plasmonic, antioxidant and antimicrobial properties.

Int J Nanomedicine 2018 20;13:1041-1058. Epub 2018 Feb 20.

Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy.

Purpose: The leaves and flowering stem of contain essential oils, flavonoids, phenolic acids and anthocyanins. We propose a new, simple, one-pot, extract (OVE) mediated green synthesis method of biocompatible gold nanoparticles (AuNPs) possessing improved antioxidant, antimicrobial and plasmonic properties.

Materials And Methods: Different concentrations of OVEs were used to reduce gold ions and to synthetize biocompatible spherical AuNPs. Read More

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http://dx.doi.org/10.2147/IJN.S149819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824763PMC
April 2018
7 Reads

Binding kinetics of ultrasmall gold nanoparticles with proteins.

Nanoscale 2018 Feb;10(7):3235-3244

Department of Biochemistry, Federal University of São Paulo, São Paulo, SP, Brazil.

Synthetic ultrasmall nanoparticles (NPs) can be designed to interact with biologically active proteins in a controlled manner. However, the rational design of NPs requires a clear understanding of their interactions with proteins and the precise molecular mechanisms that lead to association/dissociation in biological media. Although much effort has been devoted to the study of the kinetics mechanism of protein corona formation on large NPs, the nature of NP-protein interactions in the ultrasmall regime is radically different and poorly understood. Read More

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http://dx.doi.org/10.1039/c7nr06810gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842697PMC
February 2018
4 Reads

Interaction mechanisms between α-FeO, γ-FeO and FeO nanoparticles and Citrus maxima seedlings.

Sci Total Environ 2018 Jun 3;625:677-685. Epub 2018 Jan 3.

Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:

The interactions between α-FeO, γ-FeO, and FeO nanoparticles (NPs) and Citrus maxima seedlings were examined so as to better understand possible particle applications as an Fe source for crop plants. NPs toxicity to the exposed plant was investigated as well. The α- and γ-FeO NPs were accumulated by plant root cells through diapirism and endocytosis, respectively, but translocation to the shoots was negligible. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697173370
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http://dx.doi.org/10.1016/j.scitotenv.2017.12.276DOI Listing
June 2018
23 Reads

Formation of Silver Nanoparticles Using Fluorescence Properties of Chitosan Oligomers.

Mar Drugs 2018 Jan 3;16(1). Epub 2018 Jan 3.

Department of Advance Organic Materials and Textile System, Chungnam National University, Daejeon 34134, Korea.

In this study, silver chloride nanoparticles (AgCl NPs) were prepared using chitosan oligomer (CHI) and chitosan oligomer derivatives (CHI-FITC). The CHI and CHI-FITC were used as markers to confirm the formation of AgCl NPs using their fluorescence properties as well as stabilizers. The fluorescence properties of CHI and CHI-FITC were monitored by a luminescence spectrophotometer, and the morphology of the AgCl NPs was further confirmed by transmission electron microscopy (TEM) and X-ray diffraction (XRD). Read More

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http://dx.doi.org/10.3390/md16010011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793059PMC
January 2018
5 Reads

pH-responsive gold nanoclusters-based nanoprobes for lung cancer targeted near-infrared fluorescence imaging and chemo-photodynamic therapy.

Acta Biomater 2018 03 30;68:308-319. Epub 2017 Dec 30.

Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, PR China; National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:

Nanoparticle-based drug delivery systems have drawn a great deal of attention for their opportunities to improve cancer treatments over intrinsic limits of conventional cancer therapies. Herein, we developed the polypeptide-modified gold nanoclusters (GNCs)-based nanoprobes for tumor-targeted near-infrared fluorescence imaging and chemo-photodynamic therapy. The nanoprobes comprise of tetra-functional components: i) polyethylene glycol (PEG) shell for long blood circulation and better biocompatibility; ii) MMP2 polypeptide (CPLGVRGRGDS) for tumor targeting; iii) cis-aconitic anhydride-modified doxorubicin (CAD) for pH-sensitive drug release; iv) photosensitizer chlorin e6 (Ce6) for photodynamic therapy and fluorescence imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061173080
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http://dx.doi.org/10.1016/j.actbio.2017.12.034DOI Listing
March 2018
20 Reads

Probing the interaction of zero valent iron nanoparticles with blood system by biophysical, docking, cellular, and molecular studies.

Int J Biol Macromol 2018 Apr 19;109:639-650. Epub 2017 Dec 19.

Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University of Tehran (IAUPS), Iran. Electronic address:

Human exposure to nanoparticles (NPs) is inevitable as NPs become more widely applied and, as a result, nanotoxicology study is now gaining attention. Herein, the interaction of zero valent iron NPs (ZVFe-NPs) with human hemoglobin (Hb) was evaluated using a variety of techniques including fluorescence spectroscopy, far circular dichroism (CD) spectroscopy as well as docking study. Also, the cytotoxicity of ZVFe-NPs on the human lymphocyte cell line as a model of blood system cell line was investigated by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), acridine orange/ethidium bromide (AO/EB) staining, flow cytometry, and real-time PCR assays. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2017.12.085DOI Listing
April 2018
6 Reads

ROS-mediated heme degradation and cytotoxicity induced by iron nanoparticles: hemoglobin and lymphocyte cells as targets.

J Biomol Struct Dyn 2017 Dec 18:1-11. Epub 2017 Dec 18.

g Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch , Islamic Azad University (IAUPS) , Tehran , Iran.

Nanoparticles (NPs) due to their small size and high surface area induce remarkable adverse effects on the biological systems. However, the exact mechanism by which NPs interacted with biological system and induce their adverse effects is still an enigma. Herein, the interaction of zero valent iron NPs (ZVFe NPs) with human hemoglobin (Hb) was evaluated using a variety of techniques including circular dichroism, fluorescence, and UV-visible (UV-vis) spectroscopy methods. Read More

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http://dx.doi.org/10.1080/07391102.2017.1411832DOI Listing
December 2017
4 Reads

Ultrasmall-in-Nano Approach: Enabling the Translation of Metal Nanomaterials to Clinics.

Bioconjug Chem 2018 01 20;29(1):4-16. Epub 2017 Dec 20.

Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia , Piazza San Silvestro 12-56126, Pisa, Italy.

Currently, nanomaterials are of widespread use in daily commercial products. However, the most-promising and potentially impacting application is in the medical field. In particular, nanosized noble metals hold the promise of shifting the current medical paradigms for the detection and therapy of neoplasms thanks to the: (i) localized surface plasmon resonances (LSPRs), (ii) high electron density, and (iii) suitability for straightforward development of all-in-one nanoplatforms. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00664DOI Listing
January 2018
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Probing the interaction of silver nanoparticles with tau protein and neuroblastoma cell line as nervous system models.

J Biomol Struct Dyn 2018 Nov 21;36(15):4057-4071. Epub 2017 Dec 21.

f Faculty of Advance Science and Technology, Department of Nanotechnology , Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS) , Tehran , Iran.

Interestingly pharmaceutical sciences are using nanoparticles (NPs) to design and develop nanomaterials-based drugs. However, up to recently, it has not been well realized that NPs themselves may impose risks to the biological systems. In this study, the interaction of silver nanoparticles (AgNPs) with tau protein and SH-SY5Y neuroblastoma cell line, as potential nervous system models, was examined with a range of techniques including intrinsic fluorescence spectroscopy, circular dichroism (CD) spectroscopy, 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and acridine orange/ethidium bromide (AO/EB) dual staining method. Read More

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http://dx.doi.org/10.1080/07391102.2017.1407673DOI Listing
November 2018
5 Reads

Meta-synthesis on nurse practitioner autonomy and roles in ambulatory care.

Nurs Forum 2018 Apr 27;53(2):148-155. Epub 2017 Oct 27.

College of Nursing, University of Colorado Denver, Aurora, CO.

Background: Many healthcare stakeholders view nurse practitioners (NPs) as an important workforce resource to help fill the anticipated shortage of 20,400 ambulatory care physicians that is expected by 2020. Multiple quantitative studies revealed the attributes of NPs' practice autonomy and roles. However, there is no qualitative meta-synthesis that describes the experiences of NPs' practice autonomy and roles. Read More

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http://dx.doi.org/10.1111/nuf.12236DOI Listing
April 2018
2 Reads

Biokinetics of Nanomaterials: the Role of Biopersistence.

NanoImpact 2017 Apr 22;6:69-80. Epub 2017 Mar 22.

German Federal Institute for Risk Assessment, Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.

Nanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined future categorization of NMs. Read More

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http://dx.doi.org/10.1016/j.impact.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645051PMC
April 2017
16 Reads

Stakeholder Perspectives on the Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) Project.

Gerontologist 2018 11;58(6):1177-1187

Regenstrief Institute, Indianapolis, Indiana.

Background And Objectives: The need to reduce burdensome and costly hospitalizations of frail nursing home residents is well documented. The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project achieved this reduction through a multicomponent collaborative care model. We conducted an implementation-focused project evaluation to describe stakeholders' perspectives on (a) the most and least effective components of the intervention; (b) barriers to implementation; and (c) program features that promoted its adoption. Read More

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http://dx.doi.org/10.1093/geront/gnx155DOI Listing
November 2018
6 Reads

Size-dependent melting modes and behaviors of Ag nanoparticles: a molecular dynamics study.

Nanotechnology 2017 Dec;28(48):485704

School of Mechano-Electronic Engineering, Xidian University, Xi'an 710071, Shaanxi, People's Republic of China.

The size-dependent melting behaviors and mechanisms of Ag nanoparticles (NPs) with diameters of 3.5-16 nm were investigated by molecular dynamics (MD). Two distinct melting modes, non-premelting and premelting with transition ranges of about 7-8 nm, for Ag NPs were demonstrated via the evolution of distribution and transition of atomic physical states during annealing. Read More

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http://dx.doi.org/10.1088/1361-6528/aa92acDOI Listing
December 2017
7 Reads

Case series of mild behavioral impairment: toward an understanding of the early stages of neurodegenerative diseases affecting behavior and cognition.

Int Psychogeriatr 2018 02 11;30(2):273-280. Epub 2017 Oct 11.

Department of Clinical Neurosciences,Hotchkiss Brain Institute,University of Calgary,Calgary,Canada.

Mild behavioral impairment (MBI) is characterized by later life acquired, sustained, and impactful neuropsychiatric symptoms (NPS) of any severity that cannot be better accounted for by other formal medical and psychiatric nosology. MBI is an "at risk" state for incident cognitive decline and dementia, and for some, MBI is the index manifestation of neurodegeneration, observed in advance of cognitive impairment. Initially described in Frontotemporal Dementia (FTD), MBI evolved to describe a preclinical stage of all cause dementia, and has been operationalized in the International Society to Advance Alzheimer's Research and Treatment-Alzheimer's Association (ISTAART-AA) proposed research diagnostic criteria. Read More

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http://dx.doi.org/10.1017/S1041610217001855DOI Listing
February 2018
11 Reads

Prevalence estimates of mild behavioral impairment in a population-based sample of pre-dementia states and cognitively healthy older adults.

Int Psychogeriatr 2018 02 21;30(2):221-232. Epub 2017 Sep 21.

Centre for Research on Ageing,Health and Wellbeing,Research School of Population Health,The Australian National University,Canberra,Australia.

Background: A dearth of population-based epidemiological research examines neuropsychiatric symptom (NPS) in sub-clinical populations across the spectrum from normal aging to mild cognitive impairment (MCI). The construct of mild behavioral impairment (MBI) describes the emergence of sustained and impactful NPS in advance of or in combination with MCI. This is the first epidemiological study to operationalize the recently published diagnostic criteria for MBI and determine prevalence estimates across the spectrum from cognitively normal to MCI. Read More

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http://dx.doi.org/10.1017/S1041610217001909DOI Listing
February 2018
9 Reads