990 results match your criteria ACS omega[Journal]


Synthesis of a 3,4-Disubstituted 1,8-Naphthalimide-Based DNA Intercalator for Direct Imaging of .

ACS Omega 2019 Mar 26;4(3):5829-5838. Epub 2019 Mar 26.

Laboratory for Quantum Semiconductors and Photon-Based BioNanotechnology, Interdisciplinary Institute for Technological Innovation (3IT), CNRS UMI-3463, Department of Electrical and Computer Engineering, Université de Sherbrooke, Sherbrooke, Québec J1K 0A5, Canada.

The development of organic molecules to target nucleic acid is an active area of research at the interface of chemistry and biochemistry, which involves DNA binding, nuclear imaging, and antitumor studies. These molecules bind with DNA through covalent interactions, electrostatic interactions, or intercalation. However, they are less permeable to membrane, and they have a significant cytotoxicity, which limits their application under in vivo conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463538PMC

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu.

ACS Omega 2019 Mar 15;4(3):5356-5366. Epub 2019 Mar 15.

Department of Physical and Environmental Science, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada.

Understanding the factors that give rise to tau aggregation and reactive oxygen species (ROS) is the key aspect in Alzheimer's disease pathogenesis. Microtubule (MT) binding repeats of tau protein were suggested to play a critical role in tau aggregation. Here, we show that the interaction of Cu with full-length MT binding repeats R1-R4 leads to the aggregation, and a Cys-based redox chemistry is critically involved in tau aggregation leading to disulfide-bridge dimerization of R2 and R3 and further aggregation into a fibrillar structure. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b03595
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b03595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463671PMC
March 2019
1 Read

Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine.

ACS Omega 2019 Mar 19;4(3):5547-5555. Epub 2019 Mar 19.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, Department of Microbiology & Immunology, Lineberger Comprehensive Cancer Center, and Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Multiple studies have been published emphasizing the significant role of nanoparticle (NP) carriers in antigenic peptide-based subunit vaccines for the induction of potent humoral and cellular responses. Various design parameters of nanoparticle subunit vaccines such as linker chemistry, the proximity of antigenic peptide to NPs, and the density of antigenic peptides on the surface of NPs play an important role in antigen presentation to dendritic cells (DCs) and in subsequent induction of CD8+ T cell response. In this current study, we evaluated the role of peptide antigen proximity and density on DC uptake, antigen cross-presentation, in vitro T cell proliferation, and in vivo induction of CD8+ T cells. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b03391
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b03391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450662PMC
March 2019
2 Reads

Cobalt Phthalocyanine-Sensitized Graphene-ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent.

ACS Omega 2019 Mar 21;4(3):5696-5704. Epub 2019 Mar 21.

Department of Chemistry, Prairie View A&M University, Prairie View, Texas 77446, United States.

Herein, a promising near-infrared-responsive photothermal agent was designed by anchoring of rice grain-shaped ZnO particles over graphene (GR) nanosheets and subsequent sensitization with cobalt phthalocyanine (CoPc). Thus, produced GR-ZnO-CoPc was able to attain the temperature of 68 °C by irradiating to 980 nm laser for 7 min, which is extremely higher than the endurance temperature of cancer cells. The linear fashioned progression in the photothermal effect of GR nanosheets was conquered by immobilization of ZnO particles and successive sensitization with CoPc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441945PMC
March 2019
1 Read

Impact of Thermal Oxidative Stabilization on the Performance of Lignin-Based Carbon Nanofiber Mats.

ACS Omega 2019 Mar 15;4(3):5345-5355. Epub 2019 Mar 15.

Advanced Renewable Materials Laboratory, Department of Wood Science and Advanced Fibrous Materials Laboratory, Department of Materials Engineering, University of British Columbia, Vancouver, BC, Canada V6T1Z4.

Lignin is a renewable biopolymer considered as a potential precursor for low-cost carbon materials. Thermal oxidative stabilization (TOS) is an important processing step to maintain fiber geometry during carbonization, yet the impact of  TOS on the properties of lignin-based carbon materials has not been clearly identified in the literature. Yield, change in fiber diameter/distribution, elemental composition, and mechanical properties were explored for both stabilized and carbonized lignin fibers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443214PMC
March 2019
1 Read

Synthetic Minimal Cell: Self-Reproduction of the Boundary Layer.

ACS Omega 2019 Mar 13;4(3):5293-5303. Epub 2019 Mar 13.

Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.

A critical aspect in the bottom-up construction of a synthetic minimal cell is to develop an entity that is capable of self-reproduction. A key role in this process is the expansion and division of the boundary layer that surrounds the compartment, a process in which content loss has to be avoided and the barrier function maintained. Here, we describe the latest developments regarding self-reproduction of a boundary layer with a focus on the growth and division of phospholipid-based membranes in the context of a synthetic minimal cell. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443216PMC

Liposomal Fc Domain Conjugated to a Cancer Vaccine Enhances Both Humoral and Cellular Immunity.

ACS Omega 2019 Mar 13;4(3):5204-5208. Epub 2019 Mar 13.

Department of Medicinal and Biological Chemistry and Department of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.

Targeted delivery of antigens to antigen-presenting cells (APCs) by utilizing natural anticarbohydrate antibodies is a promising approach for selective uptake and enhanced antigen presentation. Previously, we reported that in the presence of a natural antibody, anti-rhamnose antibody (anti-Rha), the bacterial sugar rhamnose conjugated with liposomal cancer antigen MUC1-Tn enhances antigen presentation by APCs such as dendritic cells by targeting Fc gamma receptors. The idea was to utilize the natural human anti-Rha antibodies present in human serum for targeted delivery of cancer-specific antigens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441943PMC
March 2019
1 Read

Rep and UvrD Antagonize One Another at Stalled Replication Forks and This Is Exacerbated by SSB.

ACS Omega 2019 Mar 12;4(3):5180-5196. Epub 2019 Mar 12.

Center for Single Molecule Biophysics, Department of Microbiology and Immunology, Department of Biochemistry, University at Buffalo, Buffalo, New York 14214, United States.

The Rep and UvrD DNA helicases are proposed to act at stalled DNA replication forks to facilitate replication restart when RNA polymerase stalls forks. To clarify the role of these DNA helicases in fork rescue, we used a coupled spectrophotometric ATPase assay to determine how they act on model fork substrates. For both enzymes, activity is low on regressed fork structures, suggesting that they act prior to the regression step that generates a Holliday junction. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b02375
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b02375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441946PMC
March 2019
6 Reads

Material Characterization and Bioanalysis of Hybrid Scaffolds of Carbon Nanomaterial and Polymer Nanofibers.

ACS Omega 2019 Mar 8;4(3):5044-5051. Epub 2019 Mar 8.

Department of Biological Sciences, Wichita State University, 1845 Fairmount Street, Wichita, Kansas 67260-0026, United States.

The interconnected porous structures that mimic the extracellular matrix support cell growth in tissue engineering. Nanofibers generated by electrospinning can act as a vehicle for therapeutic cell delivery to a neural lesion. The incorporation of carbon nanomaterials with excellent electrical conductivity in nanofibers is an attractive aspect for design of a nanodevice for neural tissue regeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b00197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441941PMC
March 2019
1 Read

Pt Nanoparticles Loaded on WO Nanocables-rGO Nanocomposite as a Highly Active and Durable Catalyst for Methanol Electro-Oxidation.

ACS Omega 2018 Dec 7;3(12):16850-16857. Epub 2018 Dec 7.

CAS Center for Excellence in Nanoscience, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.

Highly active and durable electrocatalysts are vital for commercialization of direct methanol fuel cells. In this work, a three-dimensional nanocomposite consisting of platinum nanoparticles, WO nanocables, and reduced graphene oxide composite (Pt/WO NCs-rGO) has been prepared as an electrocatalyst for methanol oxidation reaction (MOR). The catalyst is prepared through a two-step method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432879PMC
December 2018
2 Reads

Ameloblastin Binds to Phospholipid Bilayers via a Helix-Forming Motif within the Sequence Encoded by Exon 5.

ACS Omega 2019 Feb;4(2):4405-4416

Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, Los Angeles, California 90033, United States.

Ameloblastin (Ambn), the most abundant non-amelogenin enamel protein, is intrinsically disordered and has the potential to interact with other enamel proteins and with cell membranes. Here, through multiple biophysical methods, we investigated the interactions between Ambn and large unilamellar vesicles (LUVs), whose lipid compositions mimicked cell membranes involved in epithelial cell-extracellular matrix adhesion. Using a series of Ambn Trp/Phe variants and Ambn mutants, we further showed that Ambn binds to LUVs through a highly conserved motif within the sequence encoded by exon 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410667PMC
February 2019
1 Read

Comparison of K- and N- Mutagenic Hot Spots for UVC Damage.

ACS Omega 2019 Feb 15;4(2):3469-3475. Epub 2019 Feb 15.

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

It has been well established that mutations in K- and N- proto-oncogenes can convert them into active oncogenes. Current molecular cancer research has been focused on determining the key steps by which cellular genes become oncogenes and not on the underlying and fundamental chemical damage mechanism and susceptibility to damage. In this study, we investigate the damage hot spots present in the N- and K- genes upon exposure to UVC radiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410678PMC
February 2019

Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain Inhibitor Pyrvinium.

ACS Omega 2019 Feb 1;4(2):2472-2481. Epub 2019 Feb 1.

Department of Medical Oncology and Department of Molecular Medicine, City of Hope, East Duarte Road, 1500 Duarte, California, United States.

Pyrvinium was identified as the first small molecule inhibitor of the androgen receptor (AR) DNA-binding domain (DBD). It was also among the first small molecules shown to directly inhibit the activity of AR splice variants (ARVs), which has important clinical implications in the treatment of castration-resistant prostate cancer. Important questions about pyrvinium's mechanism of action remain. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b03205
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b03205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410682PMC
February 2019
3 Reads

Metal-Assisted and Microwave-Accelerated Decrystallization of Pseudo-Tophus in Synthetic Human Joint Models.

ACS Omega 2019 Feb;4(2):4417-4428

Department of Civil Engineering, Department of Physics and Engineering Physics, and Department of Biology, Morgan State University, 1700 East Cold Spring Lane, Baltimore, Maryland 21251, United States.

In this paper, we tested a hypothesis that the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique, based on the combined use of low-power medical microwave heating (MWH) and gold nanoparticles (Au NPs), can be used to decrystallize laboratory-prepared monosodium urate monohydrate crystal aggregate (pseudo-tophus) placed in three-dimensional (3D) synthetic human joint models. To simulate a potential treatment of chronic tophaceous gout using the MAMAD technique, we used three different 3D synthetic human joint models and assessed the percent mass reduction (PMR, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407899PMC
February 2019
1 Read

Differential Glycosylation Expression in Injured Rat Spinal Cord Treated with Immunosuppressive Drug Cyclosporin-A.

ACS Omega 2019 Feb 12;4(2):3083-3097. Epub 2019 Feb 12.

Discipline of Anatomy and NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway H91 W5P7, Ireland.

Glycosylation is ubiquitous throughout the central nervous system and altered following spinal cord injury (SCI). The glial scar that forms following SCI is composed of several chondroitin sulfate proteoglycans, which inhibit axonal regrowth. Cyclosporin-A (CsA), an immunosuppressive therapeutic, has been proposed as a potential treatment after SCI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407839PMC
February 2019
5 Reads

Nanomedical Relevance of the Intermolecular Interaction Dynamics-Examples from Lysozymes and Insulins.

ACS Omega 2019 Feb 27;4(2):4206-4220. Epub 2019 Feb 27.

RI-B-NT Research Institute of Bioinformatics and Nanotechnology, Franziusallee 177, 24148 Kiel, Germany.

Insulin and lysozyme share the common features of being prone to aggregate and having biomedical importance. Encapsulating lysozyme and insulin in micellar nanoparticles probably would prevent aggregation and facilitate oral drug delivery. Despite the vivid structural knowledge of lysozyme and insulin, the environment-dependent oligomerization (dimer, trimer, and multimer) and associated structural dynamics remain elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398350PMC
February 2019
5 Reads

Highlighting the Influence of Thermodynamic Coupling on Kinetic Separations with Microporous Crystalline Materials.

Authors:
Rajamani Krishna

ACS Omega 2019 Feb 15;4(2):3409-3419. Epub 2019 Feb 15.

Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.

The main focus of this article is on mixture separations that are driven by differences in intracrystalline diffusivities of guest molecules in microporous crystalline adsorbent materials. Such "kinetic" separations serve to over-ride, and reverse, the selectivities dictated by mixture adsorption equilibrium. The Maxwell-Stefan formulation for the description of intracrystalline fluxes shows that the flux of each species is coupled with that of the partner species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398361PMC
February 2019

Design, Synthesis, and Characterization of Fully Zwitterionic, Functionalized Dendrimers.

ACS Omega 2019 Feb 11;4(2):3000-3011. Epub 2019 Feb 11.

Laboratory of Organic Chemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, The Netherlands.

Dendrimers are interesting candidates for various applications because of the high level of control over their architecture, the presence of internal cavities, and the possibility for multivalent interactions. More specifically, zwitterionic dendrimers modified with an equal number of oppositely charged groups have found use in in vivo biomedical applications. However, the design and control over the synthesis of these dendrimers remains challenging, in particular with respect to achieving full modification of the dendrimer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398351PMC
February 2019
4 Reads

A FRET-Based Fluorogenic Trehalose Dimycolate Analogue for Probing Mycomembrane-Remodeling Enzymes of Mycobacteria.

ACS Omega 2019 Feb 27;4(2):4348-4359. Epub 2019 Feb 27.

Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.

The mycobacterial outer membrane, or mycomembrane, is essential for the viability and virulence of and related pathogens. The mycomembrane is a dynamic structure, whose chemical composition and biophysical properties can change during stress to give an advantage to the bacterium. However, the mechanisms that govern mycomembrane remodeling and their significance to mycobacterial pathogenesis are still not well characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b00130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396954PMC
February 2019
4 Reads

Sustained Releasing of Methotrexate from Injectable and Thermosensitive Chitosan-Carbon Nanotube Hybrid Hydrogels Effectively Controls Tumor Cell Growth.

ACS Omega 2019 Feb 22;4(2):4040-4048. Epub 2019 Feb 22.

Department of Mechanical Engineering, Wichita State University, 1845 Fairmount Street, Wichita, Kansas 67260-0133, United States.

Injectable thermosensitive hydrogels have been widely investigated for drug delivery systems. Chitosan (CH) is one of the most abundant natural polymers, and its biocompatibility and biodegradability make it a favorable polymer for thermosensitive hydrogel formation. The addition of nanoparticles can improve its drug release behavior, remote actuation capability, and biological interactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396127PMC
February 2019
2 Reads

Microheterogeneity of Topoisomerase IA/IB and Their DNA-Bound States.

ACS Omega 2019 Feb 18;4(2):3619-3626. Epub 2019 Feb 18.

Department of Chemistry and Biochemistry and Biomolecular Sciences Institute,Florida International University, 11200 SW 8th St., AHC4-233, Miami, Florida 33199, United States.

Topoisomerases are important complex enzymes that modulate DNA topology to maintain chromosome superstructure and integrity. These enzymes are involved in many cellular processes that resolve specific DNA superstructures and intermediates. The low abundance combined with the biological heterogeneity of relevant intermediates of topoisomerases makes their structural information not readily accessible using traditional structural biology tools (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396120PMC
February 2019
3 Reads

Novel 2-(5-Imino-5-isoquinolones[3,4-]quinoxalin-7-ylmethyl)-benzonitrile () and Other Related Derivatives Targeting Colon Cancer Cells: Syntheses and in Vitro Models.

ACS Omega 2019 Feb 14;4(2):3205-3212. Epub 2019 Feb 14.

Department of Biology, and Center for Drug Discovery, and Department of Chemistry, American University of Beirut, Riad El Solh, 1107 2020 Beirut, Lebanon.

Chemotherapy has been shown to be effective in reducing the progression and development of cancer in metastatic patients. However, drug selectivity is still a major issue for most chemotherapeutics. In this study, we synthesized four novel heterocyclic compounds having similarity in structure with quinone systems whereby nitrogen atoms replace the oxygen atoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396124PMC
February 2019
1 Read

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding.

ACS Omega 2019 Feb 8;4(2):2921-2930. Epub 2019 Feb 8.

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, Texas 77030, United States.

Approximately 15% of all human tumors harbor mutant KRAS, a membrane-associated small GTPase and notorious oncogene. Mutations that render KRAS constitutively active will lead to uncontrolled cell growth and cancer. However, despite aggressive efforts in recent years, there are no drugs on the market that directly target KRAS and inhibit its aberrant functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396121PMC
February 2019
1 Read

pH- and Temperature-Dependent Peptide Binding to the Oligopeptide-Binding Protein A Measured with a Fluorescence Anisotropy Assay.

ACS Omega 2019 Feb 6;4(2):2812-2822. Epub 2019 Feb 6.

Department of Chemistry, Institute for Integrative Neuroscience, and Institute for Inflammation, Immunology, and Infectious Disease, Purdue University, 560 Oval Drive Box 68, West Lafayette, Indiana 47907, United States.

Bacterial ATP-binding cassette transporters are a superfamily of transport systems involved in the import of various molecules including amino acids, ions, sugars, and peptides. In the lactic acid bacteria , the oligopeptide-binding protein A (OppA) binds peptides for import to support nitrogen metabolism and cell growth. The OppA protein is of great interest because it can bind peptides over a broad variety of lengths and sequences; however, current methods to study peptide binding have employed low throughput, endpoint, or low dynamic range techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396125PMC
February 2019

Solution Structure of a Promoter G-Quadruplex with 1:6:1 Loop Length.

ACS Omega 2019 Feb 1;4(2):2533-2539. Epub 2019 Feb 1.

College of Pharmacy, Medicinal Chemistry and Molecular Pharmacology, Purdue University, 575 W Stadium Avenue, West Lafayette, Indiana 47907, United States.

The important oncogene is deregulated in many cancer cells and comprises one of the most prominent G-quadruplex (G4) forming sequences in its promoter regions, the NHE III motif. Formation of G4s suppresses transcription and can be modulated by drug binding, establishing these DNA structures as promising targets in cancer therapy. The NHE III motif can fold into more than one parallel G4s, including 1:2:1 and 1:6:1 loop length conformers, with the 1:2:1 conformer shown as the major species under physiological conditions in solution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396123PMC
February 2019
2 Reads

Methionine Attenuates Lipopolysaccharide-Induced Inflammatory Responses via DNA Methylation in Macrophages.

ACS Omega 2019 Jan 30;4(1):2331-2336. Epub 2019 Jan 30.

State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.

Methionine (Met) is an essential and multifunctional nutrient in vertebrate diets. It is a precursor of -adenosylmethionine (SAM), the methyl donor for DNA methylation, which has an important role in the inflammatory responses. However, whether Met exerts anti-inflammatory effects by altering DNA methylation in macrophages is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374979PMC
January 2019
2 Reads

Correlating Live Cell Viability with Membrane Permeability Disruption Induced by Trivalent Chromium.

ACS Omega 2019 Jan 28;4(1):2142-2151. Epub 2019 Jan 28.

Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 5B7, Canada.

Cr(III) is often regarded as a trace essential micronutrient that can be found in many dietary supplements due to its participation in blood glucose regulation. However, increased levels of exposure have been linked to adverse health effects in living organisms. Herein, scanning electrochemical microscopy (SECM) was used to detect variation in membrane permeability of single cells (T24) resulting from exposure to a trivalent Cr-salt, CrCl. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374964PMC
January 2019
1 Read

Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue.

ACS Omega 2019 Jan 16;4(1):1470-1478. Epub 2019 Jan 16.

Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3 Vancouver, British Columbia, Canada.

The gastrin-releasing peptide receptor (GRPR), a G protein-coupled receptor, is overexpressed in solid malignancies and particularly in prostate cancer. We synthesized a novel bombesin derivative, [Ga]Ga-ProBOMB1, evaluated its pharmacokinetics and potential to image GRPR expression with positron emission tomography (PET), and compared it with [Ga]Ga-NeoBOMB1. ProBOMB1 (DOTA-pABzA-DIG-d-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-ψ(CHN)-Pro-NH) was synthesized by solid-phase peptide synthesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372246PMC
January 2019

Co-Benefits of Wollastonite Weathering in Agriculture: CO Sequestration and Promoted Plant Growth.

ACS Omega 2019 Jan 16;4(1):1425-1433. Epub 2019 Jan 16.

School of Engineering, University of Guelph, 50 Stone Road East, Guelph N1G 2W1, Ontario, Canada.

To lock atmospheric CO at anthropogenic timescale, fast weathering silicates can be applied to soil to speed up natural CO sequestration via enhanced weathering. Agricultural lands offer large area for silicate application, but expected weathering rates as a function of soil and crop type, and potential impacts on the crops, are not well known. This study investigated the role of plants on enhanced weathering of wollastonite (CaSiO) in soils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374988PMC
January 2019

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

ACS Omega 2019 Jan 9;4(1):755-764. Epub 2019 Jan 9.

Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

Tetrahydroisoquinoline (THIQ) 6--sulfamate-based anticancer agents, inspired by the endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored for antiproliferative and microtubule disruptor activity. Based on recently designed C3-methyl C7-methoxy-substituted THIQ derivatives, compounds with mono- and dichloro-substitutions on the pendant -benzyl ring were synthesized and evaluated. Although improved antiproliferative activity was observed, for example, versus and versus , it was relatively modest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372245PMC
January 2019

Evidence for Hidden Involvement of N3-Protonated Guanine in RNA Structure and Function.

ACS Omega 2019 Jan 9;4(1):699-709. Epub 2019 Jan 9.

Center for Computational Natural Sciences and Bioinformatics (CCNSB), International Institute of Information Technology, Hyderabad (IIIT-H), Gachibowli, Hyderabad 500032, Telangana, India.

Charged nucleobases have been found to occur in several known RNA molecules and are considered essential for their structure and function. The mechanism of their involvement is however not yet fully understood. Revelation of the role of N7-protonated guanine, in modulating the geometry and stability of noncanonical base pairs formed through its unprotonated edges [Watson-Crick (WC) and sugar], has triggered the need to evaluate the feasibility of similar roles of other protonated nucleobases [Halder et al. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b02908
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b02908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372247PMC
January 2019
7 Reads

Benchmarking Smartphone Fluorescence-Based Microscopy with DNA Origami Nanobeads: Reducing the Gap toward Single-Molecule Sensitivity.

ACS Omega 2019 Jan 9;4(1):637-642. Epub 2019 Jan 9.

Institute for Physical & Theoretical Chemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), and Laboratory for Emerging Nanometrology (LENA), Braunschweig University of Technology, Rebenring 56, 38106 Braunschweig, Germany.

Smartphone-based fluorescence microscopy has been rapidly developing over the last few years, enabling point-of-need detection of cells, bacteria, viruses, and biomarkers. These mobile microscopy devices are cost-effective, field-portable, and easy to use, and benefit from economies of scale. Recent developments in smartphone camera technology have improved their performance, getting closer to that of lab microscopes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372172PMC
January 2019
1 Read

Crystal Growth of Metal-Organic Framework-5 around Cellulose-Based Fibers Having a Necklace Morphology.

ACS Omega 2019 Jan 3;4(1):169-175. Epub 2019 Jan 3.

Department of Chemical Engineering, McMaster University, Hamilton L8S 4L7, Ontario, Canada.

Herein, metal-organic framework (MOF)-5 crystals were grown on cellulose-based substrates including paper and cotton. Dopamine was used as a surface modification agent to improve the compatibility between MOF-5 crystals and the used substrates. The formed polydopamine film promoted the growth of MOF-5 crystals, which were bonded to the substrates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374995PMC
January 2019

Gene Expression Profiling of Endoplasmic Reticulum Stress in Hepatitis C Virus-Containing Cells Treated with an Inhibitor of Protein Disulfide Isomerases.

ACS Omega 2018 Dec 13;3(12):17227-17235. Epub 2018 Dec 13.

Department of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie Street, Ottawa, Ontario K1N 6N5, Canada.

Protein disulfide isomerases (PDIs) catalyze disulfide bond formation between protein cysteine residues during protein folding in the endoplasmic reticulum (ER) lumen and are essential for maintaining ER homoeostasis. The life cycle of the hepatitis C virus (HCV) is closely associated with the ER. Synthesis and maturation of HCV proteins occur in the ER membrane and are mediated by multiple host cell factors that include also PDI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369735PMC
December 2018
2 Reads

Electrochemical Oxidation of Organic Pollutants Powered by a Silicon-Based Solar Cell.

ACS Omega 2018 Oct 30;3(10):14392-14398. Epub 2018 Oct 30.

Photovoltaic Materials and Devices (PVMD), Electrical Engineering, Mathematics and Computer Science Faculty and Sanitary Engineering, Civil Engineering Faculty, Delft University of Technology, 2628 CD Delft, The Netherlands.

Currently available (photo-)electrochemical technologies for water treatment establish a trade-off between low-pollutant concentration and costs. This paper aims at decoupling these two variables by designing a photo-oxidation device using earth abundant materials and an electronic-free approach. The proposed device combines a graphite/graphite electrochemical system with a silicon-based solar cell that provides the necessary electrical power. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369653PMC
October 2018

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads.

ACS Omega 2019 Jan 30;4(1):2353-2361. Epub 2019 Jan 30.

Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.

We have previously described the first Bayesian machine learning models from FDA-approved drug screens, for identifying compounds active against the Ebola virus (EBOV). These models led to the identification of three active molecules in vitro: tilorone, pyronaridine, and quinacrine. A follow-up study demonstrated that one of these compounds, tilorone, has 100% in vivo efficacy in mice infected with mouse-adapted EBOV at 30 mg/kg/day intraperitoneal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356859PMC
January 2019
10 Reads

Multiplex Viral Detection Platform Based on a Aptamers-Integrated Microfluidic Channel.

ACS Omega 2019 Jan 29;4(1):2234-2240. Epub 2019 Jan 29.

Advanced Materials Processing and Analysis Centre, Department of Materials Science and Engineering, Department of Internal Medicine, College of Medicine, and Nanoscience Technology Centre, University of Central Florida, Orlando, Florida 32827, United States.

A polydimethylsiloxane-based microfluidic device has been developed for the multiplex detection of viral envelope proteins such as Zika and chikungunya on a single platform using aptamer-analyte interactions. The channel is integrated with microsized pillars that increase the surface area allowing more aptamers to attach to the incoming envelope protein molecules, thus increasing the overall sensitivity of the system. The working of the device depends on the formation of protein-mediated sandwich morphology that is obtained using an aptamer and aptamer-functionalized gold nanoparticle (AuNP) pair. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358057PMC
January 2019

Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure.

ACS Omega 2019 Jan 15;4(1):1272-1280. Epub 2019 Jan 15.

Mississippi Center for Heart Research, Department of Physiology and Biophysics, Department of Preventive Medicine and Cancer Institute, Jackson Heart Study, and Division of Cardiology, UMMC, Jackson, Mississippi 39216-4505, United States.

We hypothesized that identifying plasma glycoproteins that predict the development of heart failure following myocardial infarction (MI) could help to stratify subjects at risk. Plasma collected at visit 2 (2005-2008) from an MI subset of Jackson Heart Study participants underwent glycoproteomics and was grouped by the outcome: (1) heart failure hospitalization after visit 2 ( = 15) and (2) without hospitalization by 2012 ( = 45). Proteins were mapped for biological processes and functional pathways using Ingenuity Pathway Analysis and linked to clinical characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356850PMC
January 2019
8 Reads

Tsuji-Trost Cyclization of Disulfonamides: Synthesis of 12-Membered, 11-Membered, and Pyridine-Fused Macrocyclic Triamines.

ACS Omega 2019 Jan 15;4(1):1254-1264. Epub 2019 Jan 15.

Department of Chemistry, University of Nevada, Reno, Nevada 89557-0216, United States.

Macrocyclic triamine disulfonamides can be synthesized by double Tsuji-Trost -allylation reaction of open-chain disulfonamides with 2-alkylidene-1,3-propanediyl bis(carbonates). The previously used Atkins-Richman macrocyclization method generally gives lower yields and requires more tedious purification of the product. Solvent, palladium source, ligand, and concentration have all been varied to optimize the yields of two key 12-membered ring bioactive compounds, CADA and VGD020. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356871PMC
January 2019
1 Read

Preparation and Evaluation of ZD2 Peptide Cu-DOTA Conjugate as a Positron Emission Tomography Probe for Detection and Characterization of Prostate Cancer.

ACS Omega 2019 Jan 14;4(1):1185-1190. Epub 2019 Jan 14.

Department of Biomedical Engineering and Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106, United States.

Positron emission tomography (PET) is a sensitive modality for cancer molecular imaging. We aim to develop a PET probe for sensitive detection and risk stratification of prostate cancer by targeting an abundant microenvironment oncoprotein, extradomain-B fibronectin (EDB-FN). The probe consists of a small ZD2 peptide specific to EDB-FN and a Cu-DOTA chelate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356864PMC
January 2019

Controlled Delivery of Salmon Calcitonin Using Thermosensitive Triblock Copolymer Depot for Treatment of Osteoporosis.

ACS Omega 2019 Jan 14;4(1):1157-1166. Epub 2019 Jan 14.

Department of Pharmaceutical Sciences, School of Pharmacy, College of Health Professions, North Dakota State University, Fargo 58105, North Dakota, United States.

Osteoporosis is a common metabolic bone disorder associated with fragility and bone fracture. Worldwide, osteoporosis results in more than 8.9 million fractures annually. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356892PMC
January 2019
1 Read

Roles of ZnO in Cu/Core-Shell Al-MCM-41 for NO Reduction by Selective Catalytic Reduction with NH: The Effects of Metal Loading and Cu/ZnO Ratio.

ACS Omega 2019 Jan 14;4(1):1077-1085. Epub 2019 Jan 14.

Department of Chemical Engineering, Faculty of Engineering and Research Network of NANOTEC-KU on NanoCatalysts and NanoMaterials Sustainable Energy and Environment, Kasetsart University, Bangkok 10900, Thailand.

Cu-ZnO/Al-MCM-41 catalysts were studied for NO reduction. The total metal loading was varied as 3, 5, and 7 wt %, whereas the Cu-to-ZnO ratio was fixed at 1:1. Too high metal loading led to lower reducibility of Cu, as CuO and ZnO covers on the catalyst surface could partially block pores and hinder gas molecules to access the Cu ions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358062PMC
January 2019
1 Read

Multimeric Rhodamine Dye-Induced Aggregation of Silver Nanoparticles for Surface-Enhanced Raman Scattering.

ACS Omega 2019 Jan 3;4(1):140-145. Epub 2019 Jan 3.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.

Isotopic variants of Rhodamine 6G (R6G) have previously been used as a method of multiplexed detection for Surface Enhanced Raman Spectroscopy (SERS), including protein detection and quantification. Challenges exist, however, with producing long-term stable SERS signals with exposure to silver or gold metal surfaces without the use of additional protective coatings of nanomaterials. Here, novel rhodamine "dimers" and "trimers" have been created that demonstrate a higher avidity for metal nanoparticles and induce aggregation to create plasmonic "hotspots" as indicated by enhanced Raman scattering . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356857PMC
January 2019
2 Reads

Effect of Calcium Ions and Disulfide Bonds on Swelling of Virus Particles.

ACS Omega 2019 Jan 2;4(1):58-64. Epub 2019 Jan 2.

Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Multivalent ions affect the structure and organization of virus nanoparticles. Wild-type simian virus 40 (wt SV40) is a nonenveloped virus belonging to the polyomavirus family, whose external diameter is 48.4 nm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356861PMC
January 2019

Starlike Branched Polyacrylamides by RAFT Polymerization-Part I: Synthesis and Characterization.

ACS Omega 2018 Dec 28;3(12):18762-18770. Epub 2018 Dec 28.

Department of Chemical Engineering, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Starlike branched polyacrylamides (SB-PAMs) were synthesized using reversible addition-fragmentation chain transfer copolymerization of acrylamide (AM) and ,'-methylenebis(acrylamide) (BisAM) in the presence of 3-(((benzylthio) carbonothioyl)thio)propanoic acid as a chain transfer agent, followed by chain extension with AM. The amount of incorporated BisAM in the core and the amount of AM during chain extension have been systematically varied. Core structures were achieved by incorporation of total monomer ratios [BisAM]/[AM] ranging from 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314631PMC
December 2018

Poly(glycerol sebacate)-Based Polyester-Polyether Copolymers and Their Semi-Interpenetrated Networks with Thermoplastic Poly(ester-ether) Elastomers: Preparation and Properties.

ACS Omega 2018 Dec 28;3(12):18714-18723. Epub 2018 Dec 28.

Corporate R&D Center, HLL Lifecare Limited, Akkulam PO, Sreekaryam, Trivandrum 695017, India.

Poly(glycerol sebacate) (PGS), produced from renewable monomers such as sebacic acid and glycerol, has been explored extensively for various biomedical applications. However, relatively less attention has been paid to explore PGS as sustainable materials in applications such as elastomers and rigid plastics, primarily because of serious deficiencies in physical properties of PGS. Here, we present two new approaches for enhancing the properties of PGS; (i) synthesizing block copolymers of PGS with poly(tetramethylene oxide)glycol (PTMO) and (ii) preparing a blend of PGS--PTMO with a poly(ester-ether) thermoplastic elastomer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312632PMC
December 2018

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives.

ACS Omega 2018 Dec 26;3(12):18343-18360. Epub 2018 Dec 26.

Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, Hawaii 96720, United States.

A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against and other clinically significant bacterial pathogens. Previously reported chalcone-like antibacterials (- and ) were used as a training set to generate a pharmacophore model. The chalcone derivative hit compound was subsequently identified through a pharmacophore-based virtual screen of the Specs library of >200 000 compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b03174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312637PMC
December 2018

Structural Changes in Tubulin Sheets Caused by Immobilization on Solid Supports.

ACS Omega 2018 Dec 24;3(12):18196-18202. Epub 2018 Dec 24.

Vassar College, 124 Raymond Avenue, Poughkeepsie, New York 12604, United States.

In the presence of zinc, the protein tubulin assembles into two-dimensional sheets that are a useful model system for the study of both tubulin and microtubule structure. Tubulin sheets present an ideal protein structure for study with atomic force microscopy because they contain a two-dimensional crystalline protein lattice and retain many of the structural features of tubulin and microtubules. However, high-resolution imaging requires nonperturbative immobilization onto an appropriate imaging substrate. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b02475
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b02475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312633PMC
December 2018
22 Reads

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease.

ACS Omega 2018 Dec 24;3(12):18132-18141. Epub 2018 Dec 24.

Indian Institute of Technology Mandi, Mandi 175005, Himachal Pradesh, India.

Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the context of maternal infection during pregnancy. An important target for drugs combatting Zika virus pathogenicity is NS2B-NS3 protease, which plays an essential role in hydrolysis and maturation of the flavivirus polyprotein. We identify hydroxychloroquine, a drug that already has approved uses in pregnancy, as a possible inhibitor of NS2B-NS3 protease by using a Food and Drug Administration-approved drug library, molecular docking, and molecular dynamics simulations. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsomega.8b01002
Publisher Site
http://dx.doi.org/10.1021/acsomega.8b01002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312647PMC
December 2018
11 Reads

Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents.

ACS Omega 2018 Dec 21;3(12):17991-18001. Epub 2018 Dec 21.

Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, Arkansas 72467, United States.

A cascade reaction of thioamides with 6β-bromoandrostenedione in hexafluoroisopropanol formed substituted thiazolo-androstenones. This is a simple and mild protocol to synthesize novel molecules by using readily available reagents and substrates. Feasibility of the reaction has been rationalized by density functional theory calculations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.8b02840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312635PMC
December 2018
1 Read