12,645 results match your criteria ACS nano[Journal]


Estimation of Shape, Volume, and Dipole Moment of Individual Proteins Freely Transiting a Synthetic Nanopore.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

This paper demonstrates that high-bandwidth current recordings in combination with low-noise silicon nitride nanopores make it possible to determine the molecular volume, approximate shape, and dipole moment of single native proteins in solution without the need for labeling or other chemical modifications of these proteins. The analysis is based on current modulations caused by the translation and rotation of single proteins through a uniform electric field inside of a nanopore. We applied this technique to nine proteins and show that these measured protein parameters agree well with reference values, but only if the nanopore walls were coated with a non-stick fluid lipid bilayer. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09555
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http://dx.doi.org/10.1021/acsnano.8b09555DOI Listing
April 2019
5 Reads

In-Plane Nanowires with Arbitrary Shapes on Amorphous Substrates by Artificial Epitaxy.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

The challenge of nanowire assembly is still one of the major obstacles towards their efficient integration into functional systems. One strategy to overcome this obstacle is the guided growth approach, in which the growth of in-plane nanowires is guided by epitaxial and graphoepitaxial relations with the substrate to yield dense arrays of aligned nanowires. This method relies on crystalline substrates which are generally expensive and incompatible with silicon-based technologies. Read More

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http://dx.doi.org/10.1021/acsnano.9b00538DOI Listing

Tracking Sub-Nanometer Shift in the Scattering Centroid of Single Gold Nanorods during Electrochemical Charging.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

While conventional wisdom suggests the scattering centroid of a plasmonic nanoparticle reflects its geometric center, here we uncover the dependence of scattering centroid of a single gold nanorod (AuNR) on its electron density when the geometric features (position and morphology) do not change at all. When periodically altering the electron density of a single AuNR during non-faradaic charging and discharging processes, optical centroid of the scattering dot in a series of dark-field images was found to reversibly shift back and forth by ~0.4 nm, in pace with the sweeping potential. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09636
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http://dx.doi.org/10.1021/acsnano.8b09636DOI Listing
April 2019
1 Read

Elimination Pathways of Nanoparticles.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

Understanding how nanoparticles are eliminated from the body is required for their successful clinical translation. Many promising nanoparticle formulations for in vivo medical applications are large (>6 nm) and non-biodegradable, so they cannot be eliminated renally. A proposed pathway for these nanoparticles is hepatobiliary elimination, but their transport has not been well-studied. Read More

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http://dx.doi.org/10.1021/acsnano.9b01383DOI Listing

Custom-Size, Functional, and Durable DNA Origami with Design-Specific Scaffolds.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

DNA origami nanoobjects are usually designed around generic single-stranded "scaffolds". Many properties of the target object are determined by details of those generic scaffold sequences. Here, we enable designers to fully specify the target structure not only in terms of desired 3D shape but also in terms of the sequences used. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b01025
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http://dx.doi.org/10.1021/acsnano.9b01025DOI Listing
April 2019
1 Read

Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

DNA nanotechnology provides a toolbox for creating custom and precise nanostructures with nanometer-level accuracy. These nano-objects are often static by nature and serve as versatile templates for assembling various molecular components in a user-defined way. In addition to the static structures, the intrinsic programmability of DNA nanostructures allows design of dynamic devices that can perform predefined tasks when triggered with external stimuli, such as drug delivery vehicles whose cargo display or release can be triggered with a specified physical or chemical cue in the biological environment. Read More

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http://dx.doi.org/10.1021/acsnano.9b01857DOI Listing
April 2019
1 Read

Triple-Layered Carbon-SiO2 Composite Membrane for High Energy Density and Long Cycling Li-S Batteries.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

Here we report a highly scalable yet flexible triple-layer structured porous C/SiO2 membrane via a facile phase inversion method for advancing Li-S battery technology. As a multifunctional Al foil-free cathode, the conductive dense layer of the C/SiO2 membrane offers hierarchical macropores as an ideal sulfur host to alleviate the volume expansion of sulfur species and facilitate ion/electrolyte transport for fast kinetics, as well as sponge-like pores to enable further S loading. The triple-layer structured membrane cathode enables filling most of the S species in the macropores and additional loading of a thin S slurry on the membrane surface, which facilitates ion/electrolyte transport with faster kinetics than the conventional S/C slurry-based cathode. Read More

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http://dx.doi.org/10.1021/acsnano.9b01703DOI Listing
April 2019
3 Reads

Experiments and Simulations of Complex Sugar-Based Coil-Brush Block Polymer Nanoassemblies in Aqueous Solution.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

Departments of Chemistry, Chemical Engineering, Materials Science & Engineering, and the Laboratory for Synthetic-Biologic Interactions , Texas A&M University , College Station , Texas 77843 , United States.

In this work, we investigated the fundamental molecular parameters that guide the supramolecular assembly of glucose-based amphiphilic coil-brush block polymers in aqueous solution and elucidated architecture-morphology relationships through experimental and simulation tools. Well-defined coil-brush polymers were synthesized through ring-opening polymerizations (ROP) of glucose carbonates to afford norbornenyl-functionalized poly(glucose carbonate) (NB-PGC) macromonomers, followed by sequential ring-opening metathesis polymerizations (ROMP) of norbornene N-hydroxysuccinimidyl (NHS) esters and the NB-PGC macromonomers. Variation of the macromonomer length and grafting through ROMP conditions allowed for a series of coil-brush polymers to be synthesized with differences in the brush and coil dimensions, independently, where the side chain graft length and brush backbone were used to tune the brush, and the coil block length was used to vary the coil. Read More

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http://dx.doi.org/10.1021/acsnano.8b08811DOI Listing

Atomic-Scale Chemical Conversion of Single-Layer Transition Metal Dichalcogenides.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Chemical conversion by atomic substitution offers a powerful route towards the creation of unusual structures and functionalities. Here, we demonstrate the progressive transformation of single-layer TiTe into TiSe by reaction with a Se flux in vacuum. Angle-resolved photoemission spectroscopy (ARPES) and scanning tunneling microscopy reveal intriguing reaction patterns involving TiSe island ingrowth starting from the TiTe island edges, while the band structure and core level signatures of TiSe grow in intensity at the expense of those corresponding to TiTe. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b00756
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http://dx.doi.org/10.1021/acsnano.9b00756DOI Listing
April 2019
1 Read

A Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2-Activity in Tumor Microenvironment to Prevent Breast Tumor Relapse after Chemotherapy.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Expressed in macrophages and endothelial cells, the receptor for angiopoietin, tyrosine kinase with immunoglobulin and epidermal growth factor homology -2 (Tie2), is required for the reconstruction of blood vessels in tumor recurrence after chemotherapy. Thus, small therapeutic peptides that target and block Tie2 activity are promissing, a therapeutic for the prevention of tumor relapse after chemotherapy. However, such small peptides often have low bioavailability, undergo rapid enzymatic degradation and exhibit a short circulation half-life, making them ineffective in cancer therapy. Read More

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http://dx.doi.org/10.1021/acsnano.8b08142DOI Listing

The Impact of Electron Beam Heating during 3D Nanoprinting.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

An artifact limiting the reproduction of 3D designs using nanoprinting has been quantified. Beam induced heating was determined, through complementary experiments, models and simulations, to affect the deposition rate during the 3D nanoprinting of mesh objects using focused electron beam induced deposition (FEBID). The mesh objects are constructed using interconnected nanowires. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09341
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http://dx.doi.org/10.1021/acsnano.8b09341DOI Listing
April 2019
1 Read

Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Layer-by-layer (LbL) nanoparticles offer great potential to the field of drug delivery, where these nanocomposites have been studied for their ability to deliver chemotherapeutic agents, small molecule inhibitors, and nucleic acids. Most exciting is their ability to encapsulate multiple functional elements, which allow nanocarriers to deliver complex combination therapies with staged release. However, relative to planar LbL constructs, colloidal LbL systems have not undergone extensive systematic studies that outline critical synthetic solution conditions needed for robust and efficient assembly. Read More

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http://dx.doi.org/10.1021/acsnano.9b00792DOI Listing

Fabricating CsPbX-Based Type I and Type II Heterostructures by Tuning the Halide Composition of Janus CsPbX/ZrO Nanocrystals.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices , Soochow University , 199 Ren'ai Road , Suzhou 215123 , Jiangsu , People's Republic of China.

Fabricating CsPbX-based heterostructures has proven to be a feasible way to tune their photophysical properties. Here, we report the successful fabrication of Janus CsPbX/ZrO heterostructure nanocrystals (NCs), in which each CsPbX NC is partially covered by ZrO. According to the band alignment, CsPbBr/ZrO and CsPbI/ZrO can be indexed as type I and type II composites, respectively. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b00001
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http://dx.doi.org/10.1021/acsnano.9b00001DOI Listing
April 2019
1 Read

Molecular Recognition of Structures is Key in the Polymerization of Patterned Barnacle Adhesive Sequences.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

The permanent adhesive produced by adult barnacles is held together by tightly folded proteins that form amyloid-like materials distinct among marine foulants. In this work, we link stretches of alternating charged and non-charged linear sequence from a family of adhesive proteins to their role in forming fibrillar nanomaterials. Using recombinant proteins and short barnacle cement derived peptides (BCPs), we find a central sequence with charged motifs of the pattern [Gly/Ser/Val/Thr/Ala -X], where X are charged amino acids, to exert specific control over timing, structure and morphology of fibril formation. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09194
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http://dx.doi.org/10.1021/acsnano.8b09194DOI Listing
April 2019
2 Reads

Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital , Harvard Medical School , Boston , Massachusetts 02115 , United States.

With recent advances in polymer chemistry, materials science, and nanotechnology, pH-responsive polymers have a significant impact in a number of diverse fields. Fundamental studies of these polymers are thus highly desirable as they may lead to new insights into the rational design of pH-responsive polymers with specific effects. In this Perspective, we focus on the nanobuffering of pH-responsive polymers (NBPRP). Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b01696
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http://dx.doi.org/10.1021/acsnano.9b01696DOI Listing
April 2019
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Altering the Properties of Graphene on Cu(111) by Intercalation of Potassium Bromide.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

Department of Physics , University of Basel , Klingelbergstr. 82 , 4056 Basel , Switzerland.

The catalytic growth on transition metal surfaces provides a clean and controllable route to obtain defect-free, monocrystalline graphene. However, graphene's optical and electronic properties are diminished by the interaction with the metal substrate. One way to overcome this obstacle is the intercalation of atoms and molecules decoupling the graphene and restoring its electronic structure. Read More

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http://dx.doi.org/10.1021/acsnano.9b00278DOI Listing
April 2019
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DNA Logic Operations in Living Cells Utilizing Lysosome-Recognizing Framework Nucleic Acid Nanodevices for Subcellular Imaging.

Authors:
Yi Du Pai Peng Tao Li

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemistry , University of Science and Technology of China , 96 Jinzhai Road , Hefei , Anhui 230026 , China.

DNA logic nanodevices that in situ operate within living cells have attracted increasing interest and shown great promise for gene regulation and target recognition. A challenge remains how to control their activation inside specific cellular compartments. Toward this goal, here we report a lysosome-recognizing framework nucleic acid (FNA) nanodevice using an i-motif and an ATP-binding aptamer (ABA) incorporated into a DNA triangular prism (DTP) as the logic-controlling units. Read More

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http://dx.doi.org/10.1021/acsnano.9b01324DOI Listing

Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy.

ACS Nano 2019 Apr 12. Epub 2019 Apr 12.

Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Despite considerable advances in clinical treatment of RA, suboptimal response to therapy and treatment discontinuation are still unresolved challenges due to systemic toxicity. It is of crucial importance to actively target and deliver therapeutic agents to inflamed joints in order to promote in situ activity and decrease systemic toxicity. Read More

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http://dx.doi.org/10.1021/acsnano.9b01710DOI Listing
April 2019
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The Route To Supercurrent Transparent Ferromagnetic Barriers In Superconducting Matrix.

ACS Nano 2019 Apr 12. Epub 2019 Apr 12.

A ferromagnetic barrier thinner than the coherence length in high-temperature superconductors is realized in multilayers of YBa2Cu3O7-δ and La0.67Ca0.33MnO3. Read More

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http://dx.doi.org/10.1021/acsnano.9b00888DOI Listing

Halide Ligands To Release Strain in Cadmium Chalcogenide Nanoplatelets and Achieve High Brightness.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

Laboratoire de Physique et d'Etude des Matériaux, ESPCI-Paris, PSL Research University, Sorbonne Université UPMC, Univ Paris 06, CNRS, 10 rue Vauquelin , 75005 Paris , France.

Zinc blende II-VI semiconductor nanoplatelets (NPLs) are defined at the atomic scale along the thickness of the nanoparticle and are initially capped with carboxylates on the top and bottom [001] facets. These ligands are exchanged on CdSe NPLs with halides that act as X-L-type ligands. These CdSe NPLs are costabilized by amines to provide colloidal stability in nonpolar solvents. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09794
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http://dx.doi.org/10.1021/acsnano.8b09794DOI Listing
April 2019
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Photoinduced Doping To Enable Tunable and High-Performance Anti-Ambipolar MoTe/MoS Heterotransistors.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Department of Electrical Engineering , University of Southern California , Los Angeles , California 90089 , United States.

van der Waals (vdW) p-n heterojunctions formed by two-dimensional nanomaterials exhibit many physical properties and deliver functionalities to enable future electronic and optoelectronic devices. In this report, we demonstrate a tunable and high-performance anti-ambipolar transistor based on MoTe/MoS heterojunction through in situ photoinduced doping. The device demonstrates a high on/off ratio of 10 with a large on-state current of several micro-amps. Read More

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http://dx.doi.org/10.1021/acsnano.9b00201DOI Listing

Plasmon Excitations in Mixed Metallic Nanoarrays.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

Department of Applied Physics, COMP Centre of Excellence , Aalto University School of Science , P.O. Box 11100, FI-00076 Aalto , Finland.

Features of the surface plasmon from macroscopic materials emerge in molecular systems, but differentiating collective excitations from single-particle excitations in molecular systems remains elusive. The rich interactions between single-particle electron-hole and collective electron excitations produce phenomena related to the chemical physics aspects within the atomic array. We study the plasmonic properties of atomic arrays of noble (Au, Ag, and Cu) and transition-metal (Pd, Pt) homonuclear chains using time-dependent density functional theory and their Kohn-Sham transition contributions. Read More

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http://dx.doi.org/10.1021/acsnano.8b09826DOI Listing

Copper Sulfide Facilitates Hepatobiliary Clearance of Gold Nanoparticles through the Copper-Transporting ATPase ATP7B.

ACS Nano 2019 Apr 11. Epub 2019 Apr 11.

Metallic gold (Au) nanoparticles have great potential for a wide variety of biomedical application. Yet, slow clearance of Au nanoparticles significantly hinders their clinical translation. Herein, we describe a strategy of utilizing the endogenous copper (Cu) clearance to improve the elimination of Au nanoparticles. Read More

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http://dx.doi.org/10.1021/acsnano.9b01154DOI Listing

Lasing in Ni Nanodisk Arrays.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Department of Applied Physics , Aalto University School of Science , FI-00076 Aalto , Finland.

We report on lasing at visible wavelengths in arrays of ferromagnetic Ni nanodisks overlaid with an organic gain medium. We demonstrate that by placing an organic gain material within the mode volume of the plasmonic nanoparticles both the radiative and, in particular, the high ohmic losses of Ni nanodisk resonances can be compensated. Under increasing pump fluence, the systems exhibit a transition from lattice-modified spontaneous emission to lasing, the latter being characterized by highly directional and sub-nanometer line width emission. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b01006
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http://dx.doi.org/10.1021/acsnano.9b01006DOI Listing
April 2019
1 Read

Anderson Localization for Better Thermoelectrics?

Authors:
Zhiting Tian

ACS Nano 2019 Apr 11. Epub 2019 Apr 11.

Sibley School of Mechanical and Aerospace Engineering , Cornell University , Ithaca , New York 14853 , United States.

Solid-state thermoelectrics are of great interest because they directly convert between thermal and electrical energy. However, wider application of thermoelectrics is dependent upon improving their performance. Anderson localization of charge carriers has been generally perceived as detrimental to thermoelectrics, but in their paper in this issue of ACS Nano, Lee et al. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b02399
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http://dx.doi.org/10.1021/acsnano.9b02399DOI Listing
April 2019
2 Reads

A General Approach to Free-Standing Nanoassemblies via Acoustic Levitation Self-Assembly.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

Department of Chemical Engineering, Faculty of Engineering , Monash University , Clayton 3800 , Victoria , Australia.

Droplets suspended by acoustic levitation provide genuine substrate-free environments for understanding unconventional fluid dynamics, evaporation kinetics, and chemical reactions by circumventing solid surface and boundary effects. Using a fully levitated air-water interface by acoustic levitation in conjunction with drying-mediated nanoparticle self-assembly, here, we demonstrate a general approach to fabricating free-standing nanoassemblies, which can totally avoid solid surface effects during the entire process. This strategy has no limitation for the sizes or shapes of constituent metallic nanoparticle building blocks and can also be applied to fabricate free-standing bilayered and trilayered nanoassemblies or even three-dimensional hollow nanoassemblies. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09628
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http://dx.doi.org/10.1021/acsnano.8b09628DOI Listing
April 2019
1 Read

Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au-BiS Nanoparticles via X-ray-Induced Catalytic Reaction for Radiosensitization.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049 , China.

Despite the development of nanomaterials with high-Z elements for radiosensitizers, most of them suffer from their oxygen-dependent behavior in hypoxic tumor, nonideal selectivity to tumor, or inevasible damages to normal tissue, greatly limiting their further applications. Herein, we develop a Schottky-type heterostructure of Au-BiS with promising ability of reactive free radicals generation under X-ray irradiation for selectively enhancing radiotherapeutic efficacy by catalyzing intracellular HO in tumor. On the one hand, like many other nanomaterials with rich high-Z elements, Au-BiS can deposit higher radiation dose within tumors in the form of high energy electrons. Read More

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http://dx.doi.org/10.1021/acsnano.9b01818DOI Listing
April 2019
3 Reads

Substrate Metabolism-Driven Assembly of High-Quality CdS Se Quantum Dots in Escherichia coli: Molecular Mechanisms and Bioimaging Application.

ACS Nano 2019 Apr 15. Epub 2019 Apr 15.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry , University of Science and Technology of China , Hefei 230026 , China.

Biosynthesis offers opportunities for cost-effective and sustainable production of semiconductor quantum dots (QDs), but is currently restricted by poor controllability on the synthesis process, resulting from limited knowledge on the assembly mechanisms and the lack of effective control strategies. In this work, we provide molecular-level insights into the formation mechanism of biogenic QDs (Bio-QDs) and its connection with the cellular substrate metabolism in Escherichia coli. Strengthening the substrate metabolism for producing more reducing power was found to stimulate the production of several reduced thiol-containing proteins (including glutaredoxin and thioredoxin) that play key roles in Bio-QDs assembly. Read More

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http://dx.doi.org/10.1021/acsnano.9b01581DOI Listing

Hydrophilic/Hydrophobic Interphase-Mediated Bubble-like Stretchable Janus Ultrathin Films toward Self-Adaptive and Pneumatic Multifunctional Electronics.

ACS Nano 2019 Apr 12. Epub 2019 Apr 12.

Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies , Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences , Zhongguan West Road 1219 , 315201 Ningbo , China.

As promising candidates for intelligent biomimetic applications similar to living organisms, smart soft materials have aroused extensive interest due to their extraordinarily designable structures and functionality. Herein, a bubble-like elastomer-based electronic skin that can be pneumatically actuated is achieved through hydrophilic/hydrophobic interphase mediated asymmetric functionalization. The asymmetric and controllable introduction of elastic polydimethylsiloxane into the carbon nanotube film at the air/water interface can endow the Janus ultrathin film with tunable conductivity, self-adhesivity, self-adaptivity, and even self-sealing properties. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b09600
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http://dx.doi.org/10.1021/acsnano.8b09600DOI Listing
April 2019
3 Reads

Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor.

ACS Nano 2019 Apr 12. Epub 2019 Apr 12.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , Singapore 637371 , Singapore.

Photodynamic therapy (PDT) as a treatment method has many advantages such as minimal invasiveness, repeatable dosage, and low systemic toxicity. Issues with conventional PDT agents include the limited availability of endogenous oxygen and difficulty in accumulation at the tumor site, which has hindered the successful treatment of tumors. Herein, we developed catalase-encapsulated hyaluronic-acid-based nanoparticles loaded with adamantane-modified photosensitizer for enhanced PDT of solid tumors. Read More

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http://dx.doi.org/10.1021/acsnano.9b01087DOI Listing

Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria.

ACS Nano 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemistry , The University of Sheffield , Western Bank , Sheffield S3 7HF , U.K.

Medicinal leads that are also compatible with imaging technologies are attractive, as they facilitate the development of therapeutics through direct mechanistic observations at the molecular level. In this context, the uptake and antimicrobial activities of several luminescent dinuclear Ru complexes against E. coli were assessed and compared to results obtained for another ESKAPE pathogen, the Gram-positive major opportunistic pathogen Enterococcus faecalis, V583. Read More

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http://dx.doi.org/10.1021/acsnano.8b08440DOI Listing

Nanocrystals in Molten Salts and Ionic Liquids: Experimental Observation of Ionic Correlations Extending beyond the Debye Length.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemistry and James Franck Institute , University of Chicago , Chicago , Illinois 60637 , United States.

The nature of the interface between the solute and the solvent in a colloidal solution has attracted attention for a long time. For example, the surface of colloidal nanocrystals (NCs) is specially designed to impart colloidal stability in a variety of polar and nonpolar solvents. This work focuses on a special type of colloids where the solvent is a molten inorganic salt or organic ionic liquid. Read More

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http://dx.doi.org/10.1021/acsnano.9b01292DOI Listing

Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model.

ACS Nano 2019 Apr 12. Epub 2019 Apr 12.

Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in allergic and autoimmune disease. The available options for custom-designing tolerogenic NPs include the use of nanocarriers that introduce antigens into natural tolerogenic environments, such as the liver, where antigen presentation promotes tolerance to self- or foreign antigens. Here, we demonstrate the engineering of a biodegradable polymeric poly(lactic- co-glycolic acid) (PLGA) nanocarrier for the selective delivery of the murine allergen, ovalbumin (OVA), to the liver. Read More

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http://dx.doi.org/10.1021/acsnano.9b01444DOI Listing
April 2019
1 Read

Chiral Metamolecules with Active Plasmonic Transition.

ACS Nano 2019 Apr 10. Epub 2019 Apr 10.

School of Chemistry and Chemical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , People's Republic of China.

Energy-dissipating self-assembly is at the basis of many important cellular processes, such as cell organization, proliferation, and morphogenesis. Beyond equilibrium self-assembled molecular systems and materials, it is increasingly recognized that the control of assembly kinetics provides great opportunity for the next generation of molecular materials with intelligent behavior including programmed spatiotemporal organization. Here we show the transient self-assembly of active chiral plasmonic metamolecules (CPMs), which is controlled by the proton flux generated from a positive-feedback chemical reaction network. Read More

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http://dx.doi.org/10.1021/acsnano.9b01942DOI Listing
April 2019
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12.881 Impact Factor

Polysaccharide Nanoparticles Can Efficiently Modulate the Immune Response Against an HIV Peptide Antigen.

ACS Nano 2019 Apr 9. Epub 2019 Apr 9.

The development of an effective HIV vaccine continues to be a major health challenge since, so far, only the RV144 trial has demonstrated a modest clinical efficacy. Recently, the targeting of the 12 highly conserved protease cleavage sites (PCS1-12) has been presented as a strategy seeking to hamper the maturation and infectivity of HIV. To pursue this line of research, and because peptide antigens have low immunogenicity, we have included these peptides in engineered nanoparticles, aiming at overcoming this limitation. Read More

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http://dx.doi.org/10.1021/acsnano.8b07662DOI Listing

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices.

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

School of Physics and Astronomy, Faculty of Engineering and Physical Sciences , University of Southampton , Southampton , SO17 1BJ , U.K.

DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we demonstrate that light can be employed as an external stimulus to master the stability of nanoparticle superlattices (SLs) via the promotion of a reversible photoligation of DNA in SLs. Read More

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http://dx.doi.org/10.1021/acsnano.9b01294DOI Listing

Achieving Highly Durable Random Alloy Nanocatalysts through Intermetallic Cores.

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

Department of Chemistry , Indiana University , 800 East Kirkwood Avenue , Bloomington , Indiana 47405 , United States.

Pt catalysts are widely studied for the oxygen reduction reaction, but their cost and susceptibility to poisoning limit their use. A strategy to address both problems is to incorporate a second transition metal to form a bimetallic alloy; however, the durability of such catalysts can be hampered by leaching of non-noble metal components. Here, we show that random alloyed surfaces can be stabilized to achieve high durability by depositing the alloyed phase on top of intermetallic seeds using a model system with PdCu cores and PtCu shells. Read More

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http://dx.doi.org/10.1021/acsnano.8b08007DOI Listing

Closing the Surface Bandgap in Thin BiSe/Graphene Heterostructures.

ACS Nano 2019 Apr 10. Epub 2019 Apr 10.

Department of Physics , Yonsei University , Seoul 03722 , Korea.

Topological insulator (TI), a band insulator with topologically protected edge states, is one of the most interesting materials in the field of condensed matter. Bismuth selenide (BiSe) is the most spotlighted three-dimensional TI material; it has a Dirac cone at each top and bottom surface and a relatively wide bandgap. For application, suppression of the bulk effect is crucial, but in ultrathin TI materials, with thicknesses less than 3 QL, the finite size effect works on the linear dispersion of the surface states, so that the surface band has a finite bandgap because of the hybridization between the top and bottom surface states and Rashba splitting, resulting from the structure inversion asymmetry. Read More

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http://dx.doi.org/10.1021/acsnano.8b07012DOI Listing

Modus Operandi of Protective and Anti-icing Mechanisms Underlying the Design of Longstanding Outdoor Icephobic Coatings.

ACS Nano 2019 Apr 9. Epub 2019 Apr 9.

CIC nanoGUNE , Donostia San Sebastian 20018 , Spain.

Atmospheric icing has become a global concern due to hazardous consequences of ice accretion on air, land, and sea transport and infrastructure. Icephobic surfaces due to their physicochemical properties facilitate a decrease in ice and snow accumulation under outdoor conditions. However, a serious problem of most superhydrophobic surfaces described in the literature is poor operational durability under harsh corrosive and abrasive loads characteristic of atmospheric operation. Read More

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http://dx.doi.org/10.1021/acsnano.8b09549DOI Listing
April 2019
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Formation and Healing of Defects in Atomically Thin GaSe and InSe.

ACS Nano 2019 Apr 4. Epub 2019 Apr 4.

GaSe and InSe are important members of a class of 2D materials, the III-VI metal monochalcogenides, which are attracting considerable attention due to their promising electronic and optoelectronic properties. Here an investigation of point and extended atomic defects formed in mono-, bi-, and few-layer GaSe and InSe crystals is presented. Using state-of-the-art scanning transmission electron microscopy (STEM), it is observed that these materials can form both metal and selenium vacancies under the action of the electron beam. Read More

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http://dx.doi.org/10.1021/acsnano.8b08253DOI Listing

Encapsulation of SeS into Nitrogen-Doped Free-Standing Carbon Nanofiber Film Enabling Long Cycle Life and High Energy Density K-SeS Battery.

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

Hefei National Laboratory for Physical Sciences at the Microscale, Department of Materials Science and Engineering, Key Laboratory of Materials for Energy Conversion, Chinese Academy of Sciences (CAS) , University of Science and Technology of China , Hefei , Anhui 230026 , China.

K-SeS batteries could provide a low-cost and high energy density energy storage system, because the earth-abundant element potassium (K) shows a low reduction potential and a high gravimetric capacity. But the K-SeS battery has never been reported because of the lack of high-performance electrode materials. Herein, we design an advanced K-SeS battery by encapsulation of SeS in the nitrogen-doped free-standing porous carbon matrix (SeS@NCNFs). Read More

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http://dx.doi.org/10.1021/acsnano.9b00980DOI Listing

Three-Dimensional Molecular Transfer from DNA Nanocages to Inner Gold Nanoparticle Surfaces.

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province , Hunan University , Changsha 410082 , P.R. China.

It is of great interest to construct DNA-functionalized gold nanoparticles (DNA-AuNPs) with a controllable number of DNA strands and relative orientations. Herein, we describe a three-dimensional (3D) molecular transfer strategy, in which a pattern of DNA strands can be transferred from a DNA icosahedron cage (I-Cage) to the wrapped AuNP surface. The results show that DNA-AuNPs produced by this method inherit DNA pattern information encoded in the transient I-Cage template with high fidelity. Read More

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http://dx.doi.org/10.1021/acsnano.8b09147DOI Listing
April 2019
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Two-Dimensional Gold Quantum Dots with Tunable Bandgaps.

ACS Nano 2019 Apr 4. Epub 2019 Apr 4.

Department of Physics , Michigan Technological University , 1400 Townsend Drive , Houghton , Michigan 49931 , United States.

Metallic gold nanoparticles (Au NPs) with multilayer Au atoms are useful for plasmonic, chemical, medical, and metamaterial application. In this article, we report the opening of the bandgap in substrate-supported two-dimensional (2D) gold quantum dots (Au QDs) with monolayer Au atoms. Calculations based on density functional theory suggest that 2D Au QDs are energetically favorable over 3D Au clusters when coated on hexagonal boron nitride (BN) surfaces. Read More

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http://dx.doi.org/10.1021/acsnano.8b09559DOI Listing
April 2019
12.881 Impact Factor

Ultrahigh Tough, Super Clear, and Highly Anisotropic Nanofiber-Structured Regenerated Cellulose Films.

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China.

While tremendous efforts have been dedicated to developing environmentally friendly films made from natural polymers and renewable resources, in particular, multifunctional films featuring extraordinary mechanical properties, optical performance, and ordered nanostructure, challenges still remain in achieving all these characteristics in a single material via a scalable process. Here, we designed a green route to fabricating strong, super tough, regenerated cellulose films featuring tightly stacked and long-range aligned cellulose nanofibers self-assembled from cellulose solution in alkali/urea aqueous systems. The well-aligned nanofibers were generated by directionally controlling the aggregation of cellulose chains in the hydrogel state using a preorientation-assisted dual cross-linking approach; i. Read More

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http://dx.doi.org/10.1021/acsnano.9b02081DOI Listing

Graphene as an Ideal Buffer Layer for the Growth of High-Quality Ultrathin CrO Layers on Ni(111).

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

Department of Physics , Politecnico di Milano , Milano 20133 , Italy.

Metal-oxide nanostructures play a fundamental role in a large number of technological applications, ranging from chemical sensors to data storage devices. As the size of the devices shrinks down to the nanoscale, it is mandatory to obtain sharp and good quality interfaces. Here, it is shown that a two-dimensional material, namely, graphene, can be exploited as an ideal buffer layer to tailor the properties of the interface between a metallic substrate and an ultrathin oxide. Read More

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http://dx.doi.org/10.1021/acsnano.8b09588DOI Listing
April 2019
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Catalytically Active Au Layers Grown on Pd Nanoparticles for Direct Synthesis of HO: Lattice Strain and Charge-Transfer Perspective Analyses.

ACS Nano 2019 Apr 5. Epub 2019 Apr 5.

Advanced Analysis Center , Korea Institute of Science and Technology , Seoul 02792 , South Korea.

Despite its effectiveness in improving the properties of materials, strain engineering has not yet been employed to endow catalytic characteristics to apparently nonactive metals. This limitation can be overcome by controlling simultaneously lattice strains and charge transfer originated from the epitaxially prepared bimetallic core-shell structure. Here, we report the experimental results of the direct HO synthesis enabled by a strained Au layer grown on Pd nanoparticles. Read More

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http://dx.doi.org/10.1021/acsnano.9b01394DOI Listing

Spatially Resolved Chemical Analysis of Geobacter sulfurreducens Cell Surface.

ACS Nano 2019 Apr 12. Epub 2019 Apr 12.

Center for Bio/Molecular Science and Engineering , U.S. Naval Research Laboratory , Washington , DC 20375 , United States.

Geobacter sulfurreducens is of interest for the highest efficiency of power generation and extremely long extracellular electron transfer (EET) between the bacterium and electrodes. Despite more than 15 years of intensive molecular biological research, there is still no clear answer which molecules are responsible for these processes. In the present work, we look at the problem from another (atomic) perspective and identify the location and shape of the compounds that are known to be conductive, particularly those containing Fe atoms. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.9b02032
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http://dx.doi.org/10.1021/acsnano.9b02032DOI Listing
April 2019
4 Reads

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth.

ACS Nano 2019 Apr 3. Epub 2019 Apr 3.

Department of Bioengineering , University of California , Los Angeles , California 90095 , United States.

Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. Read More

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http://dx.doi.org/10.1021/acsnano.8b09573DOI Listing
April 2019
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Disconnecting Symmetry Breaking from Seeded Growth for the Reproducible Synthesis of High Quality Gold Nanorods.

ACS Nano 2019 Apr 8. Epub 2019 Apr 8.

CIC biomaGUNE/CIBER-BBN , Paseo de Miramón 182 , 20014 Donostia-San Sebastián , Spain.

One of the major difficulties hindering the widespread application of colloidal anisotropic plasmonic nanoparticles is the limited robustness and reproducibility of multistep synthetic methods. We demonstrate herein that the reproducibility and reliability of colloidal gold nanorod (AuNR) synthesis can be greatly improved by disconnecting the symmetry-breaking event from the seeded growth process. We have used a modified silver-assisted seeded growth method in the presence of the surfactant hexadecyltrimethylammonium bromide and n-decanol as a co-surfactant to prepare small AuNRs in high yield, which were then used as seeds for the growth of high quality AuNR colloids. Read More

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http://dx.doi.org/10.1021/acsnano.8b09658DOI Listing
April 2019
1 Read