69,535 results match your criteria ACS Combinatorial Science [Journal]


The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
2 Reads

Light-Induced Activation of Forbidden Exciton Transition in Strongly Confined Perovskite Quantum Dots.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

We report the strong light-induced activation of forbidden exciton transition in CsPbBr perovskite quantum dots mediated by the symmetry-breaking polaron that modifies the optical selection rule of the confined exciton transition. The activated forbidden transition results in an intense pump-induced absorption in the transient absorption spectra above the bandgap, where the original parity-forbidden transition was located. In contrast to many other semiconductor quantum dots, photoexcitation of exciton in CsPbBr quantum dots creates a sufficiently large perturbation via lattice-distorting polaron, which turns on the formally forbidden transition. Read More

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December 2018
4 Reads
12.881 Impact Factor

Aneurysmal Subarachnoid Hemorrhage Onset Alters Pyruvate Metabolism in Poor-Grade Patients and Clinical Outcome Depends on More: A Cerebrospinal Fluid Metabolomic Study.

ACS Chem Neurosci 2018 Dec 6. Epub 2018 Dec 6.

Cerebral metabolism alterations influence cerebrospinal fluid (CSF) composition, and is sensitive to brain injury. In subarachnoid hemorrhage (SAH) patients, Fisher scale, Hunt-Hess scale and World Federation of Neurological Societies (WFNS) grading scales evaluating SAH severity are inadequate to predict long-term outcome; therefore, in an effort to determine metabolite pattern disparity and discover corresponding biomarkers, we designed an untargeted CSF metabolomic research covering a board range of metabolites of SAH patients with different severity and outcome. The present study demonstrated SAH altered cerebrospinal fluid metabolome involving carbohydrate, lipid and amino acids metabolism. Read More

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December 2018
1 Read

A Single-Step Gold Nanoparticle-Blood Serum Interaction Assay Reveals Humoral Immunity Development and Immune Status of Animals from Neonates to Adults.

ACS Infect Dis 2018 Dec 6. Epub 2018 Dec 6.

A well-developed, functional immune system is paramount to combat harmful attack from pathogenic organisms and prevent infectious diseases. Newborn animals and humans have only limited immunity upon birth, but their immune functions are expected to develop within weeks to months and eventually to reach a maturity that will provide full protection. Despite the importance of immune activity in animal and human health management, there is no convenient test available that allows for rapid assessment of the state of immune function in non-laboratory settings. Read More

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December 2018

Controlling the Activity and Stability of Electrochemical Interfaces Using Atom-by-Atom Metal Substitution of Redox Species.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

Understanding the molecular-level properties of electrochemically-active ions at operating electrode-electrolyte interfaces (EEI) is key to the rational development of high-performance nanostructured surfaces for applications in energy technology. Herein, an electrochemical cell coupled with ion soft landing is employed to examine the effect of "atom-by-atom" metal substitution on the activity and stability of well-defined redox-active anions, PMoWO (x = 0,1,2,3,6,9,12), at nanostructured ionic liquid EEI. A striking observation made by in situ electrochemical measurements and further supported by theoretical calculations is that substitution of only (1-3) tungsten by molybdenum atoms in the PWO anions results in a substantial spike in their first reduction potential. Read More

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December 2018
2 Reads

Ligand density and linker length are critical factors for multivalent nanoparticle-receptor interactions.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Although there is a large number of studies available evaluating the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0-100% surface functionalization) were combined with different PEG spacer lengths (2/3.5/5kDa) and the specific receptor binding of targeted core-shell structured PLGA/PLA-PEG nanoparticles was evaluated using αβ integrin overexpressing U87MG glioblastoma cells. Read More

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December 2018
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Phytic Acid-Assisted Formation of Hierarchical Porous CoP/C Nanoboxes for Enhanced Lithium Storage and Hydrogen Generation.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

Application of transition metal phosphides (TMPs) for electrochemical energy conversion and storage has great potential to alleviate the energy crisis. Although there are various methods to obtain TMPs, it is still immensely challenging to fabricate hierarchical porous TMPs with superior electrochemical performances by a simple, green and secure method. We herein describe a facile approach for fabricating CoP/C nanoboxes by pyrolyzing phytic acid (PA) cross-linked Co complexes that acquired from reaction of PA and ZIF-67. Read More

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December 2018
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Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease.

ACS Chem Neurosci 2018 Dec 6. Epub 2018 Dec 6.

CAS Key Laboratory of Receptor Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road , Shanghai 201203 , China.

Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical intervention in AD management. Although most clinically applied cholinesterase inhibitors (ChEIs) achieve limited clinical outcomes, research on the central cholinergic system is still thriving. Recently, an impressive amount of knowledge regarding novel acetylcholinesterase functions, as well as the close association between the central cholinergic system and other key elements for AD pathogenesis, has accumulated, highlighting that this field still has great potential for future drug development. Read More

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December 2018

Combinatorial Peptide Array Synthesis Based on Microfluidic Impact Printing.

ACS Comb Sci 2018 Dec 6. Epub 2018 Dec 6.

In this paper, a novel inkjet printing technique, micro impact printing (MI printing), is applied for the first time to combinatorial peptide array synthesis on amine functionalized micro disc arrays through standard Fmoc chemistry. MI printing shows great advantages in combinatorial peptide array synthesis compared with other printing techniques, including 1) a disposable cartridge; 2) a small spot size (80 μm) increases array density; 3) minimal loading volume (0.6 μL) and dead volume (<0. Read More

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December 2018

Determination of Handedness in a Single Chiral Nanocrystal via Circularly Polarized Luminescence.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

The occurrence of biological homochirality is attributed to symmetry breaking mechanisms which are still debatable. Studies of symmetry breaking require tools for monitoring the population ratios of individual chiral nano-objects, such as molecules, polymers or nanocrystals. Moreover, mapping their spatial distributions may elucidate on their symmetry breaking mechanism. Read More

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December 2018
1 Read

Direct Imaging of Photo-Switching Molecular Conformations Using Individual Metal Atom Markers.

ACS Nano 2018 Dec 6. Epub 2018 Dec 6.

Photo-switching behavior of individual organic molecules was imaged by annular dark-field scanning transmission electron microscopy (ADF-STEM) using a highly electron beam transparent graphene support. Photo-switching azobenzene derivatives with ligands at each ends containing single transition metal atoms (Pt) were designed (Pt-complex), and the distance between the strong ADF-STEM contrast from the two Pt atoms in each Pt-complex is used to track molecular length changes. UV irradiation was used to induce photo-switching of the Pt complex on graphene, and we show that the measured Pt-Pt distances within isolated molecules decreases from ~2. Read More

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December 2018

Oxide vs. Non-oxide Cathode Materials for Aqueous Zn Batteries: An Insight into the Charge Storage Mechanism and Consequences Thereof.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Aqueous Zn-ion batteries, which are being proposed as large scale energy storage solutions due to their unparalleled safety and cost advantage, are comprised of a positive host (cathode) material, a metallic zinc anode, and a mildly acidic aqueous electrolyte (pH ~ 3 - 7). Typically, the charge storage mechanism is believed to be reversible Zn2+ (de)intercalation in the cathode host, with the exception of α-MnO2, for which multiple vastly different and contradicting mechanisms have been proposed. However, our present study, combining electrochemical, operando X-ray diffraction (XRD), electron microscopy in conjunction with energy dispersive X-ray spectroscopy (EDX), and in situ pH evolution analyses on two oxide hosts - tunneled α-MnO2 and layered V3O7·H2O vis-à-vis two non-oxide hosts - layered VS2 and tunneled Zn3[Fe(CN)6]2, suggests that oxides and non-oxides follow two dissimilar charge storage mechanisms. Read More

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December 2018

Pt-C Interfaces Based on Electronegativity-Functionalized Hollow Carbon Spheres for Highly Efficient Hydrogen Evolution.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

State Key Laboratory of Heavy Oil Processing, Institute of New Energy , China University of Petroleum (East China) , Qingdao 266580 , P. R. China.

The hydrogen evolution reaction activity of carbon-supported Pt catalyst is highly dependent on Pt-C interfaces. Herein, we focus on the relationships between Pt activity and N/O-functionalized hollow carbon sphere (HCS) substrate in acidic media. The electrochemical dissolution of Pt counter electrode is performed to prepare Pt nanoparticles in low loading. Read More

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December 2018

Spray-Printed and Self-Assembled Honeycomb Electrodes of Silicon-Decorated Carbon Nanofibers for Li-Ion Batteries.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Directional, micron-scale honeycomb pores in Li-ion battery electrodes were fabricated using a layer-by-layer, self-assembly approach based on spray printing of carbon nanofibers. By controlling the drying behavior of each printed electrode layer through optimization of (i) the volume ratio of fugitive bi-solvent carriers in the suspension, and (ii) the substrate temperature during printing, self-assembled, honeycomb pore channels through the electrode were created spontaneously and reliably on current collector areas larger than 20 cm × 15 cm. The honeycomb pore structure promoted efficient Li-ion dynamics at high charge/discharge current densities. Read More

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December 2018
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High Energy Density Micro-Supercapacitor based on Three-Dimensional Bicontinuous Porous Carbon with Interconnected Hierarchical Pore.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

On-chip micro-supercapacitors (MSCs) are attracting great attentions recently. However, the performance of MSC is usually unsatisfactory due to the unreasonable pore structure. The construction of three-dimensional (3D) interconnected porous carbon based MSC by controllable activation is proposed. Read More

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December 2018
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Abnormal Stranski-Krastanov Mode Growth of Green InGaN Quantum Dots: Morphology, Optical Properties, and Applications in Light-Emitting Devices.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Stranski-Krastanov (SK) growth mode is widely adopted for the self-assembled growth of semiconductor quantum dots (QDs), wherein a relatively large critical thickness is essential and a thick wetting layer (WL) is formed beneath the QD layer. In this paper, we report the metal organic vapor phase epitaxy (MOVPE) of green InGaN QDs, employing a growth interruption method to decrease the critical thickness and improve the morphology of QDs. The QDs exhibit similar photoluminescence properties with those grown by conventional SK mode, implying the existence of a WL. Read More

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December 2018

Phosphorene as a Catalyst for Highly Efficient Nonaqueous Li-Air Batteries.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Li-Air batteries can yield exceptionally high predicted energy densities. However, for this technology to become realizable, round trip efficiency issues and slow kinetics at the cathode require implementation of a catalyst. With design parameters not well understood, and limitations on material selection, choosing an ideal catalyst is complex. Read More

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December 2018

Hybrid Nanomaterials of Conjugated Polymers and Albumin for Precise Photothermal Therapy.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Heretofore, conjugated polymers (CPs) attract considerable attention in photothermal therapy (PTT). Although various CPs with different structures have been reported, the suboptimal circulation persistence and biodistribution limit their efficacy in tumor treatment. Human serum albumin (HSA), an endogenous plasm protein, has been widely functioned as a carrier for therapeutic agents. Read More

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December 2018

Large magnetoelectric effects in electrodeposited nanoporous micro-disks driven by effective surface charging and magneto-ionics.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

A synergetic approach to enhance magnetoelectric effects (i.e., control of magnetism with voltage) and improve energy efficiency in magnetically actuated devices is presented. Read More

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December 2018

Toughening Nanoparticle Films via Polymer Infiltration and Confinement.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Disordered nanoparticle films have significant technological applications as coatings and membranes. Unfortunately, their use to date has been limited by poor mechanical properties, notably low fracture toughness, which often results in brittle failure and cracking. We demonstrate that the fracture toughness of TiO nanoparticle films can be increased by nearly an order of magnitude through infiltration of polystyrene into the film. Read More

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December 2018

Facile Synthesis of Amorphous Ternary Metal Borides - Reduced Graphene Oxide Hybrid with Superior Oxygen Evolution Activity.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Metal borides represent an emerging family of advanced electrocatalyst for oxygen evolution reaction (OER). Herein, we present a fast and simple method of synthesizing iron-doped amorphous nickel boride on reduced graphene oxide (rGO) sheets. The hybrid exhibits outstanding OER performance and stability in prolonged OER operation. Read More

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December 2018
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Robustly Superhydrophobic Conductive Textile for Efficient Electromagnetic Interference Shielding.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Superhydrophobic electromagnetic interference (EMI) shielding textile (EMIST) is of great significance to the safety and long-term service of all-weather outdoor equipment. However, it is still challenging to achieve long-term durability and stability under external mechanical deformations or other harsh service conditions. Herein, by designing and implementing silver nanowire (AgNW) networks and a superhydrophobic coating onto a commercial textile, we demonstrate a highly robust superhydrophobic EMIST. Read More

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December 2018

Magnetic Tunnel Junctions with a Nearly Zero Moment Manganese Nanolayer with Perpendicular Magnetic Anisotropy.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

National Institute of Advanced Industrial Science and Technology (AIST), Spintronics Research Center , Tsukuba 305-8568 , Japan.

A magnetic nanolayer with a perpendicular magnetic easy axis and negligible magnetization is demonstrated. Even though a manganese metal is antiferromagnetic in bulk form, a few manganese monolayers grown on a paramagnetic ordered alloy template and capped by an oxide layer exhibit a strong perpendicular magnetic anisotropy field exceeding 19 T as well as a negligible magnetization of 25 kA/m. The nanolayer shows tunnel magnetoresistance. Read More

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December 2018

A Photon-Responsive Antibacterial Nanoplatform for Synergistic Photothermal-/Pharmaco- Therapy of Skin Infection.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Abuse of antibiotics and their residues in the environment result in the emergence and prevalence of drug-resistant bacteria and lead to serious health problems. Herein, a photon-controlled antibacterial platform that can efficiently kill drug-resistant bacteria and avoid the generation of new bacterial resistance was designed by encapsulating black phosphorus quantum dots (BPQDs) and pharmaceutical inside a thermal-sensitive liposome. The antibacterial platform can release pharmaceutical in a spatial-, temporal- and dosage-controlled fashion since the BPQDs can delicately generate heat under near-infrared (NIR) light stimulation to disrupt the liposome. Read More

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December 2018
2 Reads

Novel insight into the role of chlorobenzene anti-solvent engineering for high efficient perovskite solar cells: gradient diluted chlorine doping.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Chlorobenzene and diethyl ether were chosen as anti-solvent to control the crystallization of CH3NH3PbI3. Under the condition of similar crystallization for both perovskite films, the obvious larger short circuit current density for CH3NH3PbI3 film treated by chlorobenzene prompted us to unveil the roles of chlorobenzene in the perovskite films via adjusting the dipping amount of chlorobenzene. A novel insight of chlorobenzene function was revealed, i. Read More

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December 2018

Interfacing a Potential Purely Organic Molecular Quantum Bit with a Real-Life Surface.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

By using a multidisciplinary and multi-technique approach, we have addressed the issue of attaching a molecular quantum bit to a real surface. First, we demonstrate that an organic derivative of the pyrene-Blatter radical is a potential molecular quantum bit. Our study of the interface of the pyrene-Blatter radical with a copper-based surface reveals that the spin of the interface layer is not cancelled by the interaction with the surface and that the Blatter-radical is resistant in presence of molecular water. Read More

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December 2018

Graphene interdigital electrodes for improving sensitivity in Ga2O3:Zn deep-ultraviolet photoconductive detector.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Graphene (Gr) has been widely used as a transparent electrode material for photodetectors due to its high conductivity and high transmittance, in recent years. However, the currently low-efficiency manipulation of Gr has hindered the arraying and practical use of such detectors. We invented a multi-step method of accurately tailoring graphene into interdigital electrodes, for fabricating a sensitive, stable deep-ultraviolet photodetector based on Zn-doped Ga2O3 films. Read More

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December 2018

Logic Sensing of MicroRNA in Living Cells Using DNA-Programmed Nanoparticle Network with High Signal Gain.

ACS Sens 2018 Dec 6. Epub 2018 Dec 6.

Molecular circuits capable of implementing Boolean logic in cellular environments have emerged as an important tool for in situ sensing, elucidating, and modulating cell functions. The performance of existing molecular computation devices in living cells is limited because of the low level of biomolecular inputs and moderate signal gain. Herein, we devised a new class of DNA-programmed nanoparticle network with integrated molecular computation and signal amplification functions for logic operation of dual microRNA (miRNA) molecules in living cells. Read More

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December 2018
2 Reads

Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity.

ACS Sens 2018 Dec 6. Epub 2018 Dec 6.

Chan Zuckerberg Biohub , San Francisco , California 94158 , United States.

An aptamer reagent that can switch its binding affinity in a pH-responsive manner would be highly valuable for many biomedical applications including imaging and drug delivery. Unfortunately, the discovery of such aptamers is difficult and only a few have been reported to date. Here we report the first experimental strategy for generating pH-responsive aptamers through direct selection. Read More

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December 2018

Nitrogen-doped carbon materials for the metal-free reduction of nitro compounds.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

In this study, nitrogen-doped carbon materials (labeled as NC-T) were easily prepared by the thermal treatment of the melamine-chitosan composite. NC-T catalysts demonstrated a good activity towards the reduction of nitro compounds by the use of hydrazine hydrate (N2H4•H2O) as the reductant. The activity of NC-T enhanced with the rise of the pyrolysis temperature because of the enhanced ratio of graphitic-type nitrogen, which should be the active sites for reduction of nitro compounds. Read More

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December 2018
2 Reads

Large-Scale Alignment of Polymer Semiconductor Nanowires for Efficient Charge Transport via Controlled Evaporation of Confined Fluids.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Long-range alignment of conjugated polymers is as critical as polymer chain packing for achieving efficient charge transport in polymer thin films used in electronic and optoelectronic devices. Here, the present study reports a facile, scalable strategy that enables the deposition of macroscopically aligned polymer semiconductor nanowire (NW)-array films with highly enhanced charge carrier mobility, using a modified controlled evaporative self-assembly (MCESA) technique. The organic field-effect transistors (OFETs) based on highly oriented poly(3-hexylthiophene) (P3HT)-NW films exhibit a more than 10-fold enhancement in the carrier mobility, with the highest mobility of 0. Read More

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December 2018

Spontaneous Acute Subdural Hematoma Associated with Arachnoid Cyst and Intra-cystic Hemorrhage.

Cureus 2018 Sep 28;10(9):e3383. Epub 2018 Sep 28.

Neurosurgery, Advocate Christ Medical Center, Oak Lawn, USA.

Arachnoid cysts (ACs) are congenital, extra-axial lesions containing fluid similar to the composition of cerebrospinal fluid. Usually found incidentally, these lesions are observed with serial imaging to document their growth patterns and stability, and are then followed conservatively until clinical symptoms develop. Surgical options for symptomatic arachnoid cysts include cyst aspiration, cyst evacuation with fenestration into the subarachnoid space, and shunt procedures including cysto-peritoneal and cysto-ventricular shunts. Read More

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September 2018

Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Molecular Innovation in Lipidology, National Cerebral & Cardiovascular Center Research Institute.

Aims: The EXPLORE-J study aimed to assess lipid management in patients hospitalized for acute coronary syndrome (ACS) and their cardiovascular risk despite undergoing standard therapy. Here, we focused on background characteristics of patients in the EXPLORE-J study to elucidate the current lipid-lowering therapy and its issues in Japan.

Methods: In this multicenter, prospective, observational study (UMIN000018946), consecutive Japanese ACS patients who required hospitalization were registered between April 2015 and August 2016. Read More

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December 2018
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Cu-substituted NiF2 as Cathode Material for Li-ion Batteries.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Metal fluorides have usually a large electronegativity and are promising electrode materials for high power lithium-ion batteries. However, like other conversion reaction based materials, large volumetric expansions and large capacity losses in cycling are major issues for metal fluorides. Here, we explore substitution of Ni with Cu for binary NiF2 and its effects to the electrochemical properties. Read More

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December 2018
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Porous Carrageenan-Derived Carbons for Efficient Ciprofloxacin Removal from Water.

Nanomaterials (Basel) 2018 Dec 4;8(12). Epub 2018 Dec 4.

CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Porous carbon materials derived from biopolymers are attractive sorbents for the removal of emerging pollutants from water, due to their high specific surface area, high porosity, tunable surface chemistry, and reasonable cost. However, carrageenan biopolymers were scarcely investigated as a carbon source to prepare porous carbon materials. Herein, hydrochars (HCs) and porous activated carbons (ACs) derived from natural occurring polysaccharides with variable sulfate content (κ-, ι- and λ-carrageenan) were prepared and investigated in the uptake of ciprofloxacin, which is an antibiotic detected in water sources and that poses serious hazards to public health. Read More

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December 2018

Acid-induced Activated Cell Penetrating Peptide Modified Cholesterol-conjugated Polyoxyethylene Sorbitol Oleate Mixed Micelles for pH-triggered Drug Release and Efficient Brain Tumor Targeting Based on a Charge Reversal Mechanism.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Glioblastoma multiforme is the most devastating malignant brain tumor in adults. Even with standard-care of therapy, the prognosis remains dismal due to tumor heterogeneity, tumor infiltration, and more importantly, the restrictive nature of the blood-brain barrier (BBB). To overcome the challenge of effectively delivering therapeutic cargo into the brain, herein a "smart," multifunctional polymeric micelle was developed using a cholesterol-conjugated polyoxyethylene sorbitol oleate. Read More

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December 2018

Reusable Enzymatic Fiber Mats for Neurotoxin Remediation in Water.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Highly effective and reusable organophosphorus hydrolase (OPH)-loaded fiber mats have been fabricated that are capable of degrading toxic organophosphates (OPs) over a broad range of relevant concentrations (from 8 ppm to 8,250 ppm). The inherent fragility of enzymes, a major impediment in their incorporation into technologically-relevant materials, was overcome while retaining their high catalytic efficiency, selectivity and sensitivity via a random heteropolymers (RHP) approach. Kinetic analysis guides the design of polycaprolactone matrix morphology from films to fibers, facilitating substrate diffusion in the material. Read More

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December 2018

Nanoengineered electroconductive collagen-based cardiac patch for infarcted myocardium repair.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive cardiac patch for treating the infarcted myocardium. Of the prepared and tested patches, only those containing spherical nanogold were able to increase connexin-43 expression in neonatal rat cardiomyocytes cultured under electrical stimulation. In vivo data indicated that only nanogold containing patches were able to recover cardiac function. Read More

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December 2018

Highly Stable and Multifunctional Aza-BODIPY-Based Phototherapeutic Agent for Anticancer Treatment.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Phototherapy, as an important class of noninvasive tumor treatment methods, has attracted extensive research interest. Although a large amount of the near-infrared (NIR) phototherapeutic agents have been reported, the low efficiency, complicated structures, tedious synthetic procedures, and poor photostability limit their practical applications. To solve these problems, herein, a donor-acceptor-donor (D-A-D) type organic phototherapeutic agent (B-3) based on NIR aza-boron-dipyrromethene (aza-BODIPY) dye has been constructed, which shows the enhanced photothermal conversion efficiency and high singlet oxygen generation ability by simultaneously utilizing intramolecular photoinduced electron transfer (IPET) mechanism and heavy atom effects. Read More

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December 2018

Direct Observation of Structural Evolution of Metal Chalcogenide in Electrocatalytic Water Oxidation.

ACS Nano 2018 Dec 3. Epub 2018 Dec 3.

As one of the most remarkable oxygen evolution reaction (OER) electrocatalysts, metal chalcogenides have been intensively reported due to their high OER activities during the past few decades. It has been reported that electron-chemical conversion of metal chalcogenides into oxides/hydroxides would take place after OER. However, the transition mechanism of such unstable structures, as well as the real active sites and catalytic activity during OER for these electrocatalysts, has not been understood yet, which urgently needs a direct observation for the electrocatalytic water oxidation process, especially at nano or even angstrom scale. Read More

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December 2018

Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy.

ACS Nano 2018 Dec 3. Epub 2018 Dec 3.

Nanoscience has long been lauded as a method through which to overcome tumor-associated barriers. As successful as cancer immunotherapy has been, limitations associated with the tumor microenvironment or side effects of systemic treatment have become more apparent. In this review, we seek to lay out the therapeutic challenges associated with the tumor microenvironment and the ways in which nanoscience is being applied to remodel the tumor microenvironment and increase the susceptibility of many cancer types to immunotherapy. Read More

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December 2018

Quantitative Imaging of Tumor Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.

ACS Nano 2018 Dec 3. Epub 2018 Dec 3.

Tumor associated macrophages (TAMs) are widely implicated in cancer progression, and TAM levels can influence drug responses, particularly to immunotherapy and nanomedicines. However, it has been difficult to quantify total TAM numbers and their dynamic spatiotemporal distribution in a non-invasive and translationally relevant manner. Here, we address this need by developing a pharmacokinetically optimized, 64Cu-labeled polyglucose nanoparticle (Macrin) for quantitative positron emission tomography (PET) imaging of macrophages in tumors. Read More

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December 2018

Ostwald Ripening Driven Exfoliation to Ultrathin Layered Double Hydroxides Nanosheets for Enhanced Oxygen Evolution Reaction.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

As a key half-reaction in water splitting, the oxygen evolution reaction (OER) process is kinetically sluggish. Layered double hydroxides (LDHs) are regarded as the highly promising electrocatalysts to promote the OER kinetics. However, the closely-stacking layered structure of pristine bulk LDHs restricts the exposure of electrocatalytic active sites, and it remains a great challenge to find an efficient strategy to exfoliate the bulk LDHs into ultrathin and stable nanosheets with increased surface area and exposed active sites. Read More

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December 2018

Oxidation-Induced Changes in the ALD-Al2O3/InAs(100) Interface and Control of the Changes for Device Processing.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

InAs crystals are emerging materials for various devices like radio-frequency transistors and infrared sensors. Control of oxidation-induced changes is essential for decreasing amounts of the harmful InAs surface (or interface) defects because it is hard to avoid the energetically favored oxidation of InAs surface parts in device processing. We have characterized atomic-layer-deposition (ALD) grown Al2O3/InAs interfaces, pre-oxidized differently, with synchrotron hard x-ray photoelectron spectroscopy (HAXPES), low-energy electron diffraction, scanning tunneling microscopy, and time-of-flight elastic recoil detection analysis. Read More

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December 2018

Profiling of Methylglyoxal Blood Metabolism and Advanced Glycation End-Product Proteome Using a Chemical Probe.

ACS Chem Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Forensic Medicine , Aarhus University , Aarhus 8200 , Denmark.

Methylglyoxal (MG) is quantitatively the most important precursor to advanced glycation end-products (AGEs), and evidence is accumulating that it is also a causally linked to diabetes and aging related diseases. Living systems primarily reside on the glyoxalase system to detoxify MG into benign d-lactate. The flux to either glycation or detoxification, accordingly, is a key parameter for how well a system handles the ubiquitous glyoxal burden. Read More

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December 2018

Manganese vanadium oxide -N-doped reduced graphene oxide composites as oxygen reduction and oxygen evolution electrocatalysts.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

The oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are key catalytic processes for sustainable energy technologies such as water electrolysis or fuel cells. Here, a novel metal oxide - nanostructured carbon composite is reported which acts as OER and ORR electrocatalyst under technologically relevant conditions. A facile synthetic process allows the deposition of a molecular manganese vanadium oxide precursor, [Mn4V4O17(OAc)3]3-, on reduced graphene oxide. Read More

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December 2018

Conformational Details of Quantum Dot-DNA Resolved by Förster Resonance Energy Transfer Lifetime Nanoruler.

ACS Nano 2018 Dec 3. Epub 2018 Dec 3.

DNA-nanoparticle conjugates are important tools in nanobiotechnology. Knowing the orientation, function, and length of DNA on nanoparticle surfaces at low nanomolar concentrations under physiological conditions is therefore of great interest. Here, we investigate the conformation of a 31 nucleotides (nt) long DNA attached to a semiconductor quantum dot (QD) via FRET (Förster resonance energy transfer) from Tb-DNA probes hybridized to different positions on the QD-DNA. Read More

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December 2018
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Wavelength-Tunable Band-Edge Photoluminescence of Nonstoichiometric Ag-In-S Nanoparticles via Ga Doping.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Graduate School of Engineering , Nagoya University , Chikusa-ku, Nagoya 464-8603 , Japan.

The nonstoichiometry of I-III-VI semiconductor nanoparticles, especially the ratio of group I to group III elements, has been utilized to control their physicochemical properties. We report the solution-phase synthesis of nonstoichiometric Ag-In-S and Ag-In-Ga-S nanoparticles and results of the investigation of their photoluminescence (PL) properties in relation to their chemical compositions. While stoichiometric AgInS nanoparticles simply exhibited only a broad PL band originating from defect sites in the particles, a narrow band edge PL peak newly appeared with a decrease in the Ag fraction in the nonstoichiometric Ag-In-S nanoparticles. Read More

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December 2018