Synthesis of highly substituted imidazole Uracil containing molecules via Ugi-4CR and Passerini-3CR.
- Rudrakshula Madhavachary,
- Tryfon Zarganes-Tzitzikas,
- Pravin Patil,
- Katarzyna Kurpiewska,
- Justyna Kalinowska-Tłuścik,
- Alexander Dömling
ACS Comb Sci 2018 Feb 19. Epub 2018 Feb 19.
The synthesis of uracil/thymine containing tetra/tri-substituted imidazoles were demonstrated using Ugi/Passerini-reaction fol-lowed by a post-cyclization reaction sequence. The approach enables the one-pot facile construction of diverse compounds in moderate to excellent yields (47-82%). The 5-fluorouracil and 5-methyluracil moieties afford potentially bioactive molecules with drug-like properties. Read More