69,779 results match your criteria ACS Chemical Biology [Journal]


Parcours de soins en situation de précarité : entre détermination et individualisation.

Sante Publique 2018 Sep;S2(HS2):157-163

The purpose of this article is to analyse healthcare pathways for precarious people, based on the results of a field study conducted in 2011 and 2012 in the north of France and Burgundy. About 40 semi-directed interviews were conducted in order to collect healthcare pathways narratives revolving around various health events during the subject's life, and putting them in perspective with individual, familial stories as well as their environment (social environment, healthcare organization, etc.). Read More

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September 2018
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Use, timing and outcome of coronary angiography in patients with high-risk non-ST-segment elevation acute coronary syndrome in daily clinical practice: insights from a 'real world' prospective registry.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Isala Heart Centre, Zwolle, The Netherlands.

Background: An early invasive strategy (EIS) is recommended in high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), defined as coronary angiography (CAG), within 24 h of admission. The aim of the present study is to investigate guideline adherence, patient characteristics associated with timing of the intervention and clinical outcome.

Methods: In a prospective registry, the use and timing of CAG and the characteristics and clinical outcome associated with timing were evaluated in high-risk ACS patients. Read More

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December 2018

Chronic obstructive pulmonary disease is an independent predictor for 30-day readmissions following 1- to 2-level posterior lumbar fusions.

J Spine Surg 2018 Sep;4(3):553-559

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality worldwide. Past literature has demonstrated that patients with COPD are at an increased risk of post-operative complications. We assessed the impact of COPD on 30-day outcomes following a 1- to 2-level posterior lumbar fusion (PLF). Read More

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September 2018

Early term effects of rhBMP-2 on pedicle screw fixation in a sheep model: histomorphometric and biomechanical analyses.

J Spine Surg 2018 Sep;4(3):534-545

Orthopaedic & Rehabilitation Engineering Center and Graduate Program in Dental Biomaterials, Marquette University, Milwaukee, WI, USA.

Background: The effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on pedicle screw pullout force and its potential to improve spinal fixation have not previously been investigated. rhBMP-2 on an absorbable collagen sponge (ACS) carrier was delivered in and around cannulated and fenestrated pedicle screws in a sheep lumbar spine instability model. Two control groups (empty screw and ACS with buffer) were also evaluated. Read More

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September 2018

Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk.

Biomed Rep 2018 Dec 19;9(6):517-522. Epub 2018 Oct 19.

Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.

The aim of the present study was to observe the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) and antithrombin III (AT-III) in patients with acute coronary syndrome (ACS), and the combination of Global Registry of Acute Coronary Events (GRACE) score to determine the value of coronary heart disease risk stratification. A total of 309 patients admitted to the Affiliated Hospital of Xuzhou Medical University were enrolled. The patients were divided into two groups: The ACS (183 cases) and control (126 cases) groups. Read More

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December 2018

Fluorine-phenanthroimidazole Porous Organic Polymer: Efficient Microwave Synthesis and Photocatalytic Activity.

ACS Appl Mater Interfaces 2018 Dec 14. Epub 2018 Dec 14.

A porous polymer containing a fluorophenylphenanthroimidazole core was easily prepared via one-pot Suzuki-Miyaura cross coupling reactions under microwave heating. These new metal-free polymers have demonstrated heterogeneous photocatalytic activity toward aza-Henry reaction with reasonable recyclability. Their preparation require a minimal workup to build porous networks with control over the apparent surface area and pore volume from suitable molecular building blocks containing the 2-(1H-phenanthro[9,10-d]imidazol-2-yl)-3,5-difluorophenol (PhIm-2F), as rigid and multitopic node which afforded a conjugated porous polymer (CPP-PhIm-2F). Read More

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December 2018

Management of Typical and Atypical Pulmonary Carcinoids Based on Different Established Guidelines.

Cancers (Basel) 2018 Dec 12;10(12). Epub 2018 Dec 12.

Division of Hematology & Oncology, Roswell Park Comprehensive Cancer Center, University at Buffalo School of Medicine, Buffalo, NY 14203, USA.

Neuroendocrine tumors (NETs) are a group of malignancies that originated from neuroendocrine cells, with the most common sites being lungs and the gastrointestinal tract. Lung NETs comprise 25% of all lung malignancies. Small cell lung cancer is the most common form of lung NETs, and other rare forms include well-differentiated typical carcinoids (TCs) and poorly differentiated atypical carcinoids (ACs). Read More

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December 2018
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Efficient Matrix-Based Channel Hopping Schemes for Blind Rendezvous in Distributed Cognitive Radio Networks.

Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.

Department of Electrical, Electronic and Systems Engineering, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.

Channel rendezvous is an initial and important process for establishing communications between secondary users (SUs) in distributed cognitive radio networks. Due to the drawbacks of the common control channel (CCC) based rendezvous approach, channel hopping (CH) has attracted a lot of research interests for achieving blind rendezvous. To ensure rendezvous within a finite time, most of the existing CH-based rendezvous schemes generate their CH sequences based on the whole global channel set in the network. Read More

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December 2018

Machine learning modeling for predicting hospital readmission following lumbar laminectomy.

Authors:

J Neurosurg Spine 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEHospital readmission contributes substantial costs to the healthcare system. The purpose of this investigation was to create a predictive machine learning model to identify lumbar laminectomy patients at risk for postoperative hospital readmission.METHODSPatients who had undergone a lumbar laminectomy procedure in the period from 2011 to 2014 were isolated from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database. Read More

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December 2018
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Structural Adaptation of Darunavir Analogs Against Primary Mutations in HIV-1 Protease.

ACS Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

HIV-1 protease is one of the prime targets of agents used in antiretroviral therapy against HIV. However, under selective pressure of protease inhibitors, primary mutations at the active site weaken inhibitor binding to confer resistance. Darunavir (DRV) is the most potent HIV-1 protease inhibitor in clinic; resistance is limited, as DRV fits well within the substrate envelope. Read More

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December 2018

In-Situ Armoring: A Robust, High-Wettability and Fire-Resistant Hybrid Separator for Advanced and Safe Batteries.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Development of non-flammable separators with excellent properties is in urgent need by next-generation advanced and safe energy storage devices. However, it has been extremely challenging to simultaneously achieve fire-resistance, high mechanical strength, good thermo-mechanical stability and low ion-transport resistance for polymeric separators. Herein, to address all these needs, we report an in-situ formed core-shell silica@ silica-imbedded polyimide (in-situ SiO@(PI/SiO)) nanofabric as a new high-performance inorganic-organic hybrid separator. Read More

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December 2018

Bottom-Up Synthesis And Mechanical Behavior Of Refractory Coatings Made Of CNT-Hafnium Diboride Composites.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

We use aligned carbon nanotube (CNT) forests as scaffolds to deposit hafnium diboride (HfB2) and fabricate millimeter-thick ultra-high temperature composite coating. HfB2 has a melting temperature of 3250°C, which makes it an attractive candidate for applications requiring operation in extreme environments. Compared to typical refractory HfB2 processing, which requires temperatures exceeding 1500°C, we use conformal HfB2 chemical vapor deposition (CVD) to coat CNT forests at a low temperature of 200°C. Read More

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December 2018

Nanoscale Core-Shell Hyperbolic Structures for Ultralow Threshold Laser Action: An Efficient Platform for the Enhancement of Optical Manipulation.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Plasmonic material has been emerged with multi-functionalities for its remarkable tailoring light emission, reshaping density of states (DOS) and focusing subwavelength light. However, restricted by its propagation loss and narrowband resonance in nature, it is a challenge issue for plasmonic material to provide a broadband DOS to advance its application. Here, we develop a novel nanoscale core-shell hyperbolic structure that possesses a remarkably coupling effect inside the multishell nanoscale composite owing to a higher DOS and longer time of collective oscillations of the electrons than the plasmonic-based pure metal nanoparticles. Read More

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December 2018

Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis of menaquinone-7.

ACS Synth Biol 2018 Dec 13. Epub 2018 Dec 13.

Menaquinone-7 (MK-7), a valuable vitamin K2, plays an important role in the prevention of osteoporosis and cardiovascular calcification. We chose B. subtilis 168 as the chassis for the modular metabolic engineering design to promote the biosynthesis of MK-7. Read More

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December 2018

Surface-controlled water flow in nanotube membranes.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

The independent effect of nanotube surface chemistry and structure on the flow of water under nanoscale confinement is demonstrated in this paper for the first time via the synthesis of novel carbon nitride nanotube (CNNT) membranes. Using a combination of experiments and high-fidelity molecular dynamics (MD) simulations, it is here shown that the hydrophilisation of the sp2 carbon structure, induced by the presence of the C-N bonds, decreases the pure water permeance in CNNTs when compared with pristine and turbostratic carbon nanotubes (CNTs). The MD simulations are based on a model true to the chemical structure of the synthesized nanotubes, and built from spectroscopy measurements and calibrated potentials using droplet experiments. Read More

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December 2018

Microporous and Flexible Framework Acoustic Metamaterials for Sound Attenuation and Contrast Agent Applications.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

The low-frequency (100-1250 Hz) acoustic properties of metal-organic framework (MOF) materials were examined in impedance tube experiments. The anomalously-high sound transmission loss of HKUST-1, FeBTC, and MIL-53(Al) quantitatively demonstrated that these prototypical MOFs are absorptive acoustic metamaterials. To the best of our knowledge this is the first example of MOFs that have been demonstrated to be acoustic metamaterials. Read More

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December 2018

Effects of Cobalt Deficiency on Nickel-rich Layered LiNiCoMnO Positive Electrode Materials for Lithium-Ion Batteries.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

The role of cobalt deficiency on the crystal structures, surface chemistry, and electrochemical performances of Ni-rich layered LiNiCoMnO (NCM811) positive electrode materials was experimentally studied possibly for the first time. We synthesized pristine and cobalt-deficient NCM811 samples by solid-state reaction. Using a variety of characterization techniques and electrochemical measurements, we show that cobalt non-stoichiometry can suppress Ni/Li cation mixing, but can simultaneously promote the formation of oxygen vacancies, leading to rapid capacity fade and inferior rate capability compared to pristine NCM811. Read More

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December 2018

3D Fe,N-Decorated Carbon-Supported NiFeP Nanoparticles as An Efficient Bifunctional Catalyst for Rechargeable Zinc-O2 Batteries.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

The electro-catalyzed oxygen reduction and evolution reactions (ORR/OER) are the key elements of many energy conversion systems, such as fuel cells, water electrolyzers and rechargeable metal-air batteries. Structural design of durable non-noble nanomaterials as bifunctional OER/ORR catalysts is a major drawback to commercial application. Herein, we exposed a strongly coupled hybrid material comprising of NiFeP-cubes nanoparticles supported on three-dimensional interconnected Fe,N-decorated carbon (3D-FeNC) as a robust bifunctional ORR/OER catalyst. Read More

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December 2018

Multifunctional Two-Dimensional Core-Shell MXene@Gold Nanocomposites for Enhanced Photo-Radio Combined Therapy in the Second Biological Window.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

Multi-functional nanoplatforms with special advantages in the diagnosis and treatment of cancer have been widely explored in nanomedicine. Herein, we synthesize two-dimensional core-shell nanocomposites (Ti3C2@Au) via a seed-growth method starting from the titanium carbide (Ti3C2) nanosheets, a classical type of MXene nanostructure. After growing gold on the surface of Ti3C2 nanosheets, the stability and biocompatibility of the nanocomposites are greatly improved by the thiol modification. Read More

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December 2018

Amyloid Fibrils Length Controls Shape and Structure of Nematic and Cholesteric Tactoids.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

Amyloid fibrils offer the possibility of controlling their contour length, aspect ratio and length distribution, without affecting other structural parameters. Here we show that a fine control in the contour length distribution of β-lactoglobulin amyloid fibrils, achieved by mechanical shear stresses of different levels, translates into the organization of tactoids of different shapes and morphologies. While longer fibrils lead to highly elongated nematic tactoids in an isotropic continuous matrix, only sufficiently shortened amyloid fibrils lead to cholesteric droplets. Read More

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December 2018

RNA Micelles for Systemic Delivery of Anti-miRNA for Cancer Targeting and Inhibition without Ligand.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

Displaying the advantage of nanoparticles in cancer targeting and drug delivery, micelles have shown great potential in cancer therapy. The mechanism for micelle targeting to cancer without the need of ligand is due to the size advantage of micelles within the lower end of the nanometer scale that is the optimal size favoring Enhanced Permeability and Retention (EPR) effect while escaping trapping by macrophages. MicroRNAs (miRNAs) are ubiquitous and play critical roles in regulating gene expression, cell growth and cancer development. Read More

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December 2018

Three-Dimensional Integrated Ultra-Low Volume Passive Microfluidics With Ion Sensitive Field Effect Transistors For Multi-Parameter Wearable Sweat Analyzers.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

Wearable systems could offer noninvasive and real-time solutions for monitoring of biomarkers in human sweat as an alternative to blood testing. Recent studies have demonstrated that the concentration of certain biomarkers in sweat, can be directly correlated to their concentrations in blood, making sweat a trusted biofluid candidate for non-invasive diagnostics. We introduce a wearable sweat sensing system to track biochemical information at the surface of the skin in real time. Read More

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December 2018

Ultrafast Carbon Dioxide Sorption Kinetics Using Morphology-Controllable Lithium Zirconate.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

It was reported that the main obstacle of Li2ZrO3 as high-temperature CO2 adsorbents is the very slow CO2 sorption kinetics, which are ascribed to the formation of solid zirconia and carbonate layers along with unreacted lithium zirconate phase; accordingly, the Li+ and O2- have to travel long distance through the solid layers by diffusion, resulting in "sticky" ions which undergo frequent trapping and detrapping. We report here that three dimensional (3D) interconnected nanoporous Li2ZrO3 is promising for CO2 capture with ultrafast kinetics. Specifically, the nanoporous Li2ZrO3 (LZ-NP) exhibited an uptake of 27 wt % of CO2 at an ultrafast adsorption rate of 10. Read More

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December 2018

Drug Discovery for Kinetoplastid Diseases: Future Directions.

ACS Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Novartis Institute for Tropical Diseases (NITD) , 5300 Chiron Way , Emeryville , California 94608 , United States.

Kinetoplastid parasites have caused human disease for millennia. Significant achievements have been made toward developing new treatments for leishmaniasis (particularly on the Indian subcontinent) and for human African trypanosomiasis (HAT). Moreover, the sustained decrease in the incidence of HAT has made the prospect of elimination a tantalizing reality. Read More

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December 2018

Charge Carrier Polarity Modulation in Diketopyrrolopyrrole-Based Low Band Gap Semiconductors by Terminal Functionalization.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Organic semiconductors with variable charge carrier polarity are required for optoelectronic applications. Herein, we report the synthesis of three novel diketopyrrolopyrrole (DPP) based D-A molecules having three different terminal groups (amide, ester and dicyano) and studied their electronic properties. Increase in electron acceptor strength from amide to dicyano, leads to a bathochromic shift in absorption. Read More

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December 2018

Amine Functionalized Metal-organic Frameworks and Covalent Organic Polymers as Potential Sorbents for Removal of Formaldehyde in Aqueous Phase: Experimental Vs. Theoretical Study.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Porous materials have been identified as efficient sorbent media to remove volatile organic compounds. To evaluate their potential as adsorbents, the adsorptive removal of formaldehyde (FA) in aqueous environments was investigated using four materials (two water-stable metal organic frameworks (MOFs) of UiO-66 (U6) and UiO-66-NH2 (U6N)) and two covalent organic polymers (COPs) with amine-functionality, CBAP-1-EDA (CE) and CBAP-1-DETA (CD)). U6N exhibited the highest removal capacity of 93% (0. Read More

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December 2018

Designing of UCNPs@Bi@SiO2 Hybrid Theranostic Nanoplatforms for Simultaneous Multimodal Imaging and Photothermal Therapy.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Herein, a novel multifunctional nanoplatform was designed towards multimodality imaging and photothermal therapy (PTT). It was found that Bi nanoparticles could grow in situ on the surface of NaYF4:20%Yb,2%Er@NaYF4:40%Yb@NaGdF4 core-shell nanoparticles (labeled as UCNPs). In this structure, UCNPs were mainly employed as upconversion luminescence (UCL) imaging agent, while the Bi nanoparticles worked as effective CT imaging and photothermal agent. Read More

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December 2018

Novel methoxymethacrylate natural products uncovered by statistics-based mining of the Myxococcus fulvus secondary metabolome.

ACS Chem Biol 2018 Dec 13. Epub 2018 Dec 13.

This study reports the uncovering of new myxobacterial natural products through comprehensive analysis of the Myxococcus fulvus secondary metabolome. Statistics-based mining of mass spectrometry data paved the way for full structure elucidation of two new secondary metabolites named fulvuthiacene A and B, and investigation of the underlying biosynthetic pathway revealed an evolutionary link between the fulvuthiacene hybrid polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) gene cluster and the related myxothiazol and melithiazol assembly lines. Detailed characterization of the post-PKS modification enzyme cascade responsible for the fulvuthiacenes' terminal β-methoxy-methylacrylate moiety was pursued by heterologous expression of these enzymes in the myxothiazol producer Stigmatella aurantiaca DW4/3-1. Read More

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December 2018

Oxygen Vacancies Boost δ-Bi2O3 as High-Performance Electrode for Rechargeable Aqueous Batteries.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Metal oxides as electrode materials are of great potential for rechargeable aqueous batteries. However,they suffer from inferior cycle stability and rate capability because of poor electronic and ionic conductivities. Herein, taking vertically-orientated Bi2O3 nanoflakes on Ti substrates as examples, we find that δ-Bi2O3 electrode with plenty of positively oxygen defects show remarkably higher specific capacity (264 mAh g-1) and far superior rate capability than that of α-Bi2O3 with less oxygen vacancies. Read More

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December 2018

Nanocombing Effect Leads to Nanowire-Based, In-Plane, Uniaxial Thin Films.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

The fabrication of thin films comprising ordered nanowire assemblies with emerging, precisely defined properties and adjustable functionalities enables highly integrated technologies in the fields of microelectronics and micro system technology, as well as for efficient power generation, storage, and utilization. Shear force, theoretically, is deemed as the most promising method for obtaining in-plane, uniaxial thin films comprising nanowires. The success depends largely on the assembly process, and uniform structural control throughout multiple length scales can be achieved only if the rational strategy is executed. Read More

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December 2018

Randomly Distributed Conjugated Polymer Repeat Units for High-Efficiency Photovoltaic Materials with Enhanced Solubility and Processability.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Department of Materials Science and Engineering , North Carolina State University , Raleigh , North Carolina 27606 , United States.

Three structurally disordered terpolymer derivatives of PffBT4T-2OD (PCE11), prepared by replacing a varied amount of bithiophene linkers with single thiophenes, were found to exhibit reduced aggregation in solution with increasing thiophene content, while important redox and optoelectronic properties remained similar to those of PffBT4T-2OD. Solar cells based on random terpolymer-PCBM blends exhibited average power conversion efficiencies of over 9.5% when processed with preheated substrates, with fill factors above 70%, exceeding those from PffBT4T-2OD. Read More

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December 2018

Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive scaffold which has positive effects on cardiac cell behaviors and cardiac tissue repair. In this study, we for the first time demonstrated that Si ions evidently stimulated the expression of cardiac specific genes and proliferation of neonatal rat cardiomyocytes (NRCMs) at concentration ranges of 0.13 ~ 10. Read More

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December 2018

Facile In Situ Synthesis of Multiple-Heteroatom-Doped Carbons Derived from Polyimide Precursors for Flexible All-Solid-State Supercapacitors.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Efficient strategies to prepare carbon materials with improved electrochemical performance for supercapacitor have been in great demand. Herein, we develop multiple-heteroatom-doped carbons (from single- to triple-doped) by pyrolysis of polyimide precursors using a facile in situ approach. This approach can be used to tune heteroatom compositions by controlling the desired polyimide monomer functional groups as well as introducing external doping sources into the polyimide precursor solutions. Read More

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December 2018

A Carbon Nanotube Bridging Method for Hole Transport Layer-Free Paintable Carbon-Based Perovskite Solar Cells.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

The incredible stability of carbon-based perovskite solar cells (C-PSCs) has aroused enormous concern. However, for the paintable C-PSCs, the fill factor (FF) and power conversion efficiency (PCE) remain low, which is because the insufficient contact at the interface between the perovskite and the electrode and the low conductivity of the electrode. In this work, a carbon nanotube (CNT) bridging method is introduced into the devices by adding single-walled carbon nanotubes (SWCNTs) in both perovskite and carbon layers to form a high-quality perovskite/carbon interface. Read More

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December 2018

Triplet Harvesting by a Fluorescent Emitter using a Phosphorescent Sensitizer for Blue Organic Light-Emitting Diodes.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Development of highly efficient blue organic light-emitting diodes (OLEDs) with good stability is currently the most important issue in OLED displays and lighting. This paper reports an efficient blue fluorescent OLED based on a deep-blue emitting phosphorescent sensitizer ((dfpysipy)2Ir(mpic)) and a conventional fluorescent emitter (TBPe). Efficient triplet harvesting by the fluorescent emitter occurs in the OLED due to sensitization even though the difference in emission energy between the phosphorescent and fluorescent dyes was only 0. Read More

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December 2018

Specific Inhibition of Heparanase by Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Heparanase, the sole heparan sulfate polysaccharide degrading endoglycosidase enzyme, regulates multiple biological activities that enhance malignant tumor progression. High levels of heparanase are present in all types of cancers and have been correlated with increased tumor size, angiogenic activity, enhanced metastasis, and poor patient prognosis. Herein, we report a systematic investigation of the effects of multivalent inhibition of heparanase. Read More

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December 2018

Printing Birefringent Figures by Surface Tension-Directed Self-Assembly of a Cellulose Nanocrystal/Polymer Ink Components.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Photonic printing on transparent substrates using emerging synthetic photonic crystals is in high demand, especially for anti-fraud applications. However, photonic printing is faced with grand challenges including nonzero initial contrast, contrast hysteresis after stimuli removal and lack of the long-lasting stability. Natural anisotropic crystal structures and artificially molecularly arranged polymers show an optically anisotropic property known as birefringence. Read More

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December 2018

Sonication Culture of Antimicrobial Agent-Containing Cement Spacers Removed During Staged Revisions for Arthroplasty Infection.

J Clin Microbiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN.

Diagnosis of persistent infection at the time of reimplantation for staged revision of infected arthroplasties is challenging. Implant sonication culture for the diagnosis of prosthetic joint infection (PJI) has improved sensitivity compared to standard periprosthetic tissue culture. We report our experience with periprosthetic tissue culture and sonication culture of antimicrobial agent-containing cement spacers (ACSs) collected during second stages of staged revisions for arthroplasty infection. Read More

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December 2018

A multicentre, randomized, controlled open-label trial to compare an Accelerated Rule-Out protocol using combined prehospital copeptin and in-hospital high sensitive troponin with standard rule-out in patients suspected of acute Myocardial Infarction - the AROMI trial.

Trials 2018 Dec 12;19(1):683. Epub 2018 Dec 12.

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.

Background: Suspicion of acute myocardial infarction (AMI) is among the most common reasons for admission to hospital in Denmark. Owing to this suspicion, an estimated 50,000 patients are admitted every year. Only 15-20% are finally diagnosed with AMI, whereas 40% are discharged after rule-out of AMI and without initiation of any treatment or need for further admission. Read More

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December 2018

Size Matters.

Circ Arrhythm Electrophysiol 2018 Dec;11(12):e006767

Department of Cardiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, the Netherlands (ACS) (A.Z., C.V., S.B., A.C.v.R., R.N., C.P.A.).

Background: In patients with left bundle branch block (LBBB), QRS duration (QRSd) depends on left ventricular (LV) dimension. Previously, we demonstrated that normalizing QRSd to LV dimension, to adjust for variations in LV size, improved prediction of hemodynamic response to cardiac resynchronization therapy (CRT). In addition, sex-specific differences in CRT outcome have been attributed to normalized QRSd. Read More

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December 2018

Magnetite and Iodine-Containing Nano-Emulsion as Dual Modal Contrast Agent for X-Ray/MR Imaging.

ACS Appl Mater Interfaces 2018 Dec 13. Epub 2018 Dec 13.

Non-invasive diagnostic by imaging combined with contrast agent (CA) is by now the most used technique to get an insight inside human bodies. X-ray and magnetic resonance imaging (MRI) are widely used technologies providing complementary results. Nowadays, it seems clear that bimodal CAs could be an emerging approach to increase the patient compliance, accessing the different imaging modalities with a single CA injection. Read More

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December 2018

Intra-Articular Injections of Autologous Conditioned Serum to Treat Pain from Meniscal Lesions.

Authors:
Rudolf Strümper

Sports Med Int Open 2017 Oct 29;1(6):E200-E205. Epub 2017 Sep 29.

Privatpraxis Orthopädie im Rheinauhafen, Cologne, Germany.

Routine use of biological therapies is in its early stages. Techniques involve stem cells, platelet preparations, recombinant growth factors and autologous conditioned serum, often combined with surgery. The objective of this case analysis was to document effects of intra-articular autologous conditioned serum injections in outpatients with knee pain associated with meniscal defects. Read More

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October 2017

Si-bridged Ladder Type Small Molecules Acceptors for High-Performance Organic Photovoltaics.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

In this study, we synthesized 5,11-dihexyl-4,4,10,10-tetraoctylbenzo[1,2-b:4,5-b']bisthieno[4´´,5´´-b´´:4´´´,5´´´-b´´´]silolo[2´´,3´´-d:2´´´,3´´´-d´]thiophene (ArSi) as a ladder-type electron-rich core for the preparation of three A-D-A-type nonfullerene acceptors (NFAs)-ArSiID, ArSiID-F, and ArSiID-Cl-featuring (3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (ID), 2-(5,6-difluoro-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (ID-F), and 2-(5,6-dichloro-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (ID-Cl) as peripheral electron-poor units, respectively. These molecules exhibit strong absorption covering the region of 600-850 nm. The incorporation of the halogen atoms onto the terminal units adjusted the energy levels and light harvesting ability of these materials. Read More

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December 2018

Surface-Adaptive and Initiator-Loaded Graphene as a Light-Induced Generator with Free Radicals for Drug-Resistant Bacteria Eradication.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

Since generating toxic reactive oxygen (ROS) is largely dependent on oxygen, bacteria infected wounds hypoxia significantly inhibits photodynamic therapy's (PDT) antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria is developed based on the light-activated alkyl free radical generation (that is oxygen-independent). According to the polydopamine coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was synthesized. Read More

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December 2018

Block junction-functionalized all-conjugated donor-acceptor block copolymers.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

Junction-functionalized donor-acceptor (D-A) block copolymers (BCPs) enable spatial and electronic control over interfacial charge dynamics in excitonic devices such as solar cells. Here we present the design, synthesis, morphology and electronic characterization of block junction-functionalized, all-conjugated, all-crystalline D-A BCPs. Poly(3-hexylthiophene) (P3HT), a single thienylated diketopyrrolopyrrole (ThxDPPThx, x=1 or 2) unit and poly{[N,N'-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5'-(2,2'-bithiophene)} (PNDIT2) is used as donor, interfacial unit and acceptor, respectively. Read More

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December 2018

Defective MnxZr1-xO2 solid solution for the catalytic oxidation of toluene: Insights into the oxygen vacancy contribution.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

Oxygen vacancy is conducive to molecular oxygen adsorption and activation, and it is necessary to estimate its contribution on catalysts especially doped system for VOCs oxidation. Herein, a series of doped MnxZr1-xO2 catalysts with oxygen vacancy were prepared by substituting Zr4+ in zirconia with low-valent manganese (Mn2+) partially. Comparing with the corresponding mechanically mixed samples (MB-x) without oxygen vacancy, MnxZr1-xO2 catalysts exhibited better toluene conversion and specific reaction rate, where the difference values were calculated to estimate the contribution of oxygen vacancy on catalytic performance. Read More

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December 2018

3D Printed Graphene/PDMS Composites for Stretchable and Strain-Insensitive Temperature Sensors.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

Materials possessing exceptional temperature sensitivity and high stretchability are of importance for real time temperature monitoring on three-dimensional components with complex geometries, when operating under various external deformation modes. Herein, we develop a stretchable temperature sensor consisting of cellular graphene/polydimethylsiloxane (PDMS) composite. The first of its kind, graphene based polymer composites with desired micro-structures are produced through a direct 3D ink writing technique. Read More

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December 2018

Highly Conductive Hydrogel Polymer Fibers toward Promising Wearable Thermoelectric Energy Harvesting.

ACS Appl Mater Interfaces 2018 Dec 7. Epub 2018 Dec 7.

Jiangxi Engineering Laboratory of Waterborne Coatings , Jiangxi Science and Technology Normal University , Nanchang 330013 , People's Republic of China.

The requirement of a portable electron is functioning as a driving force for a wearable energy instrument. Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), as one of the most promising organic electron materials, has been widely studied in energy conversion devices. However, the efforts for PEDOT:PSS fibers are insufficient to boost the development of wearable thermoelectric energy harvesting. Read More

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December 2018

Social support buffers the negative effects of stress in cardiac patients: a cross-sectional study with acute coronary syndrome patients.

J Behav Med 2018 Dec 6. Epub 2018 Dec 6.

Mind, Brain, and Behavior Research Center, University of Granada, Granada, Spain.

Cardiac patients who have social support generally have better prognosis than patients who lack social support. Several theoretical mechanisms have been proposed to explain this protective effect, including the capacity of social support to buffer the negative effects of stress. We tested this buffering effect in a study of patients hospitalized for acute coronary syndrome (ACS) in Spain. Read More

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December 2018

Prevalence and predictors of high-on treatment platelet reactivity during prasugrel treatment in patients with acute coronary syndrome undergoing stent implantation.

J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy. Electronic address:

Background: ADP-antagonists such as prasugrel have reduced but yet not overcome the phenomenon of high-on treatment platelet reactivity (HRPR), that has been shown to increase the rate of major cardiovascular events after an acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI). However, the exact prevalence and the principal determinants of suboptimal platelet inhibition in patients treated with dual antiplatelet therapy (DAPT) with prasugrel have not been completely clarified and were therefore the aim of the present study.

Methods: We included patients (<75 years and >60kg) treated with DAPT (aspirin+prasugrel) after PCI, mainly for an ACS. Read More

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December 2018