10,210 results match your criteria ACP Journal Club[Journal]


Dietary supplementation of Streptococcus faecalis benefits the feed utilization, antioxidant capability, innate immunity, and disease resistance of blunt snout bream (Megalobrama amblycephala).

Fish Physiol Biochem 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

This study aimed to investigate the effects of Streptococcus faecalis on the growth performance, intestinal histology, antioxidant capability, innate immunity, and disease resistance of blunt snout bream Megalobrama amblycephala. Fish were fed five experimental diets containing 0 (SF0, control), 1 × 10 (SF1), 1 × 10 (SF2), 1 × 10 (SF3), and 1 × 10 cfu/g (SF4) of Streptococcus faecalis, respectively, for 10 weeks. After the feeding trial, fish were challenged by Aeromonas hydrophila with the cumulative mortality recorded during a period of 96 h. Read More

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December 2018

Membrane-Located Expression of Thioesterase From Enhances Free Fatty Acid Production With Decreased Toxicity in sp. PCC6803.

Front Microbiol 2018 27;9:2842. Epub 2018 Nov 27.

Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

It has been previously reported that photosynthetic production of extracellular free fatty acids (FFAs) in cyanobacteria was realized by thioesterases (TesA) mediated hydrolysis of fatty acyl-ACP in cytosol and excretion of the FFA outside of the cell. However, two major issues related to the genetically modified strains need to be addressed before the scale-up commercial application becomes possible: namely, the toxicity of FFAs, and the diversity of carbon lengths of fatty acids that could mimic the fossil fuel. To address those issues, we hypothesized that generating FFAs near membrane could facilitate rapid excretion of the FFA outside of the cell and thus decrease toxicity caused by intracellular FFAs in the cytosolic expression of thioesterase. Read More

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November 2018

Predictors of Advance Care Planning in Older Women: The Nurses' Health Study.

J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.

Department of Health Policy, Vanderbilt University School of Medicine, Nashville, Tennessee.

Background/objectives: Relatively little is known regarding predictors of advance care planning (ACP) in former nurses. We aimed to evaluate potential predictors of ACP documentation and discussion.

Design: Cross-sectional study, 2012-2014. Read More

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December 2018

Gibberellin Promotes Cell Growth and Induces Changes in Fatty Acid Biosynthesis and Upregulates Fatty Acid Biosynthetic Genes in Chlorella vulgaris UMT-M1.

Appl Biochem Biotechnol 2018 Dec 10. Epub 2018 Dec 10.

Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Terengganu, Terengganu, Malaysia.

Microalgae lipids and oils are potential candidates for renewable biofuels and nutritional inventions. Recent studies from our lab have shown that two plant hormones, auxin and jasmonic acid, influence microalgae growth and fatty acid accumulation. Therefore, in this study, a high oil-producing strain Chlorella vulgaris UMT-M1 was selected for hormonal study using gibberellin (GA). Read More

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December 2018
1 Read

Advance care planning for patients with cancer in the palliative phase in Dutch general practices.

Fam Pract 2018 Dec 10. Epub 2018 Dec 10.

Department of Primary and Community Care, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: Advance care planning (ACP) is a crucial element of palliative care. It improves the quality of end-of-life care and reduces aggressive and needless life-prolonging medical interventions. However, little is known about its application in daily practice. Read More

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December 2018

Cloning of the pks3 gene of Aurantiochytrium limacinum and functional study of the 3-ketoacyl-ACP reductase and dehydratase enzyme domains.

PLoS One 2018 11;13(12):e0208853. Epub 2018 Dec 11.

Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao, People's Republic of China.

Aurantiochytrium limacinum has received attention because of its abundance of polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA). DHA is synthesized through the polyketide synthase (PKS) pathway in A. limacinum. Read More

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December 2018

The antibiotic resistance-free mammalian expression plasmid vector pPAL for development of third generation vaccines.

Plasmid 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Parasitology, Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (Consejo Superior de Investigaciones Científicas). Calle Ramiro de Maeztu, 9, 28040 Madrid, Spain. Electronic address:

DNA vaccines require a vector to replicate genes and express encoding antigens. Antibiotic resistance genes are often used as selection markers, which must not be released to the environment upon final product commercialization. For this reason, generation of antibiotic resistance-free vectors is imperative. Read More

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December 2018

Total arch replacement using a 4-branched graft with antegrade cerebral perfusion.

J Thorac Cardiovasc Surg 2018 Oct 17. Epub 2018 Oct 17.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.

Objective: Total arch replacement (TAR) is an established standard surgical procedure. We report >1000 cases of TAR using a 4-branched graft with antegrade cerebral perfusion (ACP) during a 15-year period.

Methods: Since May 2001, 1005 patients who underwent total aortic replacement (mean age 69. Read More

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October 2018

N 235 - Prise en charge active du troisième stade du travail: Prévention et prise en charge de l'hémorragie postpartum.

J Obstet Gynaecol Can 2018 Dec;40(12):e856-e873

Ottawa (Ont.).

Objectif: Analyser les aspects cliniques de l'hémorragie postpartum (HPP) et fournir des lignes directrices visant à guider les cliniciens pour ce qui est de la prévention et de la prise en charge de l'HPP. La présente directive clinique est une mise à jour de la directive clinique précédente de la Société des obstétriciens et gynécologues du Canada (SOGC) sur l'HPP, publiée en avril 2000. RéSULTATS: Des recherches ont été menées dans Medline, PubMed, la Cochrane Database of Systematic Reviews, le ACP Journal Club et le BMJ Clinical Evidence afin d'en tirer les articles pertinents, en portant une attention particulière aux essais comparatifs randomisés (ECR), aux analyses systématiques et aux directives cliniques publiées entre 1995 et 2007. Read More

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December 2018

No. 235-Active Management of the Third Stage of Labour: Prevention and Treatment of Postpartum Hemorrhage.

J Obstet Gynaecol Can 2018 Dec;40(12):e841-e855

Ottawa, ON.

Objective: To review the clinical aspects of postpartum hemorrhage (PPH) and provide guidelines to assist clinicians in the prevention and management of PPH. These guidelines are an update from the previous Society of Obstetricians and Gynaecologists of Canada (SOGC) clinical practice guideline on PPH, published in April 2000.

Evidence: Medline, PubMed, the Cochrane Database of Systematic Reviews, ACP Journal Club, and BMJ Clinical Evidence were searched for relevant articles, with concentration on randomized controlled trials (RCTs), systematic reviews, and clinical practice guidelines published between 1995 and 2007. Read More

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December 2018

Advance care planning in medicare/medicaid-funded agencies: providing a training in cultural competence.

Gerontol Geriatr Educ 2018 Dec 8:1-12. Epub 2018 Dec 8.

c NoVa AHEC at Mason, College of Health and Human Services , George Mason University , Fairfax , VA , USA.

This study presents a training that was developed for staff members at Medicare/Medicaid agencies to improve their knowledge and comfort levels in working on advance care planning (ACP) with their clients in a culturally competent manner. The training was developed to address the need to clarify the different types and purposes of ACP and to help develop the skills needed to work with clients of diverse cultural backgrounds. The evaluation of findings from the training showed the positive impacts that it had on participants; in particular, they exhibited demonstrated improvement in their knowledge of and comfort levels with ACP. Read More

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December 2018

Advance care planning after hospital discharge: qualitative analysis of facilitators and barriers from patient interviews.

BMC Palliat Care 2018 Dec 5;17(1):127. Epub 2018 Dec 5.

Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Background: Patients who engage in Advance Care Planning (ACP) are more likely to get care consistent with their values. We sought to determine the barriers and facilitators to ACP engagement after discharge from hospital.

Methods: Prior to discharge from hospital eligible patients received a standardized conversation about prognosis and ACP. Read More

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December 2018

How Would You Manage This Patient With Gout?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Ann Intern Med 2018 Dec;169(11):788-795

Beth Israel Deaconess Medical Center, Boston, Massachusetts (R.B.B., C.C.S., R.H.S., A.T.).

Gout is the most common form of inflammatory arthritis. In 2012, the American College of Rheumatology (ACR) issued a guideline, which was followed in 2017 by one from the American College of Physicians (ACP). The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year). Read More

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December 2018
1 Read

Simulated Molecular Evolution for Anticancer Peptide Design.

Angew Chem Int Ed Engl 2018 Dec 2. Epub 2018 Dec 2.

ETH Zurich, Chemistry and Applied Biosciences Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 4, Computer-Assisted Drug Design HCI, H411, 8093, Zurich, SWITZERLAND.

We present a simulated molecular evolution strategy for anticancer peptide (ACP) design. Starting from known ACPs, innovative bioactive peptides were automatically generated in computer-assisted design-synthesize-test cycles. The design algorithm offers a viable strategy for the design of novel peptide sequences without requiring a priori structure-activity knowledge. Read More

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December 2018
1 Read

Reproductive performance after the application of hyaluronic acid gel after dilation and curettage in women who have experienced at least one previous curettage: long-term results of a multicenter prospective randomized trial.

Fertil Steril 2018 Dec;110(7):1231-1238

Department of Obstetrics and Gynecology, Free University Medical Center, Amsterdam, The Netherlands.

Objective: To examine whether intrauterine application of auto-cross-linked hyaluronic acid (ACP) gel after dilation and curettage (D&C) improves reproductive performance.

Design: Multicenter prospective randomized trial.

Setting: One university and seven university-affiliated teaching hospitals. Read More

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December 2018

Cytochemical patterns of the peripheral blood cells in Chinese alligator (Alligator sinensis).

Tissue Cell 2018 Dec 29;55:71-76. Epub 2018 Oct 29.

Key Laboratory for Conservation and Use of Important Biological Resources of Anhui Province, College of Life Sciences, Anhui Normal University, Wuhu, Anhui, 241000, China. Electronic address:

The Chinese alligator (Alligator sinensis) is an endemic rare crocodilian species in China. In this study, we investigated the cytochemical patterns of peripheral blood cells in Chinese alligators for the first time by a range of cytochemical staining techniques including periodic acid-Schiff(PAS), sudan black B(SBB), peroxidase(POX), alkaline phosphatase(AKP), acid phosphatase(ACP), chloroacetic acid AS-D naphthol esterase(AS-D) and α-naphthol acetate esterase(α-NAE) staining. Erythrocytes were positive for PAS, and negative for all the other staining; heterophils were strongly positive for SBB, POX, ACP, AKP, AS-D and α-NAE, while weakly positive for PAS staining; eosinophils were strongly positive for PAS, POX, AKP, ACP and AS-D, and weakly positive for SBB and α-NAE staining; basophils were strongly positive for PAS, positive for POX, ACP, AKP and α-NAE, and weakly positive for AS-D, while negative for SBB staining; monocytes were weakly positive for PAS, ACP, AKP and α-NAE, while negative for SBB, POX and AS-D staining; lymphocytes were weakly positive for PAS and α-NAE, negative for all the other staining; thrombocytes were weakly positive for PAS, and negative for all the other staining. Read More

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December 2018
2 Reads

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection.

ACS Infect Dis 2018 Dec 1. Epub 2018 Dec 1.

Clostridium difficile infection (CDI) is an antibiotic-induced microbiota shift disease of the large bowel. While there is a need for narrow-spectrum CDI antibiotics, it is unclear which cellular proteins are appropriate drug targets to specifically inhibit C. difficile. Read More

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December 2018

Platelet-rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area.

Cureus 2018 Jul 18;10(7):e2999. Epub 2018 Jul 18.

Plastic Surgery, Waldkrankenhaus Bonn, Bonn, DEU.

Background Treatment of the lower eyelid region to rejuvenate the skin or treat actinic elastosis often proves difficult. Established treatment options, such as hyaluronic acid injections, botulinum toxin injections, microneedling, skin resurfacing (microdermabrasion, chemical peel (exfoliation), laser treatment), as well as blepharoplasties and autologous fat transfers, can be associated with significant risks and increased patient burden. Furthermore, they may not be effective for treating the signs of skin aging or actinic elastosis, including dark rings under the eyes, a lack of volume and cutis laxa. Read More

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July 2018
4 Reads

Biotransformation and bioconcentration of 6:2 and 8:2 polyfluoroalkyl phosphate diesters in common carp (Cyprinus carpio): Underestimated ecological risks.

Sci Total Environ 2018 Nov 23;656:201-208. Epub 2018 Nov 23.

Key Laboratory of Pollution Processes and Environmental Criteria, Ministry of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, PR China.

Polyfluoroalkyl phosphates esters (PAPs) are widely used in a variety of commercial products, and have been detected in many aquatic organisms. In this study, common carps (Cyprinus carpio) were administered with 6:2 and 8:2 diPAP in water to investigate their bio-accumulation and transformation in fish. Several degradation products, including fluorotelomer unsaturated carboxylic acids (6:2 and 8:2 FTUCA), 5:3 and 7:3 fluorotelomer carboxylic acids (5:3 and 7:3 FTCA), perfluoroalkyl carboxylates (PFCAs) were identified in the carp liver. Read More

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November 2018
1 Read

Physician Advance Care Planning Experiences and Beliefs by General Specialty Status and Sex.

South Med J 2018 Dec;111(12):721-726

From the Departments of Family Medicine, Population and Public Health Sciences, and Pediatrics, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

Objectives: Advance care planning (ACP) involvement could be substantially different by physician specialty or sex group, with implications for training and methods to increase ACP activities. The objective of this article is to compare primary care physicians (PCPs) and other specialty physicians and female compared with male physicians' views and interactions surrounding ACP.

Methods: This was a secondary analysis of an online anonymous survey distributed through a survey link to healthcare providers in hospital, ambulatory, and hospice settings in the greater Dayton, Ohio area in preparation for a community-wide advance care planning multitiered intervention. Read More

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December 2018
1 Read

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty.

Transl Vis Sci Technol 2018 Nov 27;7(6):11. Epub 2018 Nov 27.

Cornea Center and Eye Bank, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.

Purpose: To optimize methods of preparing donor cornea tissue for Descemet's stripping automated endothelial keratoplasty (DSAEK), we compared five experimental conditions with different internal pressures and cutting systems.

Methods: The artificial anterior chamber internal pressure (IP) was set at 100 or 200 mm Hg. The microkeratome cut was performed with or without an artificial chamber pressurizer (ACP), using a CBm turbine (CBm) or one use-plus automated (OUP-A). Read More

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November 2018

Frequency and characteristics of drowsiness, somnolence, or daytime sleepiness in patients with advanced cancer.

Palliat Support Care 2018 Dec 4:1-5. Epub 2018 Dec 4.

Palliative Care and Rehabilitation Medicine,The University of Texas MD Anderson Cancer Center,Houston,TX.

IntroductionCancer-related drowsiness (CRD) is a distressing symptom in advanced cancer patients (ACP). The aim of this study was to determine the frequency and factors associated with severity of CRD. We also evaluated the screening performance of Edmonton Symptom Assessment Scale-drowsiness (ESAS-D) item against the Epworth Sedation Scale (ESS). Read More

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December 2018
1 Read

Management of acute coronary syndrome in emergency departments: a cross sectional multicenter study (Tunisia).

BMC Emerg Med 2018 Dec 3;18(1):50. Epub 2018 Dec 3.

Research Laboratory (LR12SP18), University of Monastir, Monastir, Tunisia.

Background: We aimed to describe diagnosed acute coronary syndrome (ACS) and its care management and outcomes in emergency departments (EDs) and to determine related cardiovascular risk factors (CVRFs).

Methods: We conducted a cross sectional multicenter study that included 1173 adults admitted to EDs for acute chest pain (ACP) in 2015 at 14 sites in Tunisia. Data included patients' baseline characteristics, diagnosis, treatment and output. Read More

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December 2018
2 Reads

Anal Adenocarcinoma Can Masquerade as Chronic Anal Fistula in Asians.

Ann Coloproctol 2018 Dec 3. Epub 2018 Dec 3.

Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore.

Purpose: Perianal adenocarcinoma arising from a chronic anorectal fistula is a rare condition for which the natural history and optimal management are not well established. For that reason, we conducted a retrospective analysis of 5 consecutive patients with a perianal adenocarcinoma arising from a chronic anorectal fistula managed at our institution from January 2014 to December 2015.

Methods: The patients were identified from a prospectively collected colorectal cancer database that included all patients managed for colorectal cancer at our institution. Read More

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December 2018
2 Reads

Clinical Outcomes of Reduced-Port Laparoscopic Surgery for Patients With Sigmoid Colon Cancer: Surgery With 1 Surgeon and 1 Camera Operator.

Ann Coloproctol 2018 Dec 3. Epub 2018 Dec 3.

Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Purpose: This study compared the perioperative clinical outcomes of reduced-port laparoscopic surgery (RPLS) with those of conventional multiport laparoscopic surgery (MPLS) for patients with sigmoid colon cancer and investigated the safety and feasibility of RPLS performed by 1 surgeon and 1 camera operator.

Methods: From the beginning of 2010 until the end of 2014, 605 patients underwent a colectomy for sigmoid colon cancer. We compared the characteristics, postoperative outcomes, and pathologic results for the patients who underwent RPLS and for the patients who underwent MPLS. Read More

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December 2018

Evaluation of combination effects of Astragalus polysaccharides and florfenicol against acute hepatopancreatic necrosis disease-causing strain of Vibrio parahaemolyticus in Litopenaeus vannamei.

Fish Shellfish Immunol 2018 Nov 28;86:374-383. Epub 2018 Nov 28.

Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, PR China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, PR China.

The effects of oral administration of Astragalus polysaccharides (APS) and florfenicol (FFC), singly or in combination, on the survival performance, disease resistance, and immunity of Litopenaeus vannamei were investigated. After challenge with an AHPND-causing strain of Vibrio parahaemolyticus (VP), shrimp were immediately fed a drug-free diet, diets containing only APS (200 mg·kg) or FFC (15 mg·kg), or diets containing low-dose (7.5 mg·kg FFC + 100 mg·kg APS), medium-dose (15 mg·kg FFC + 200 mg·kg APS), and high-dose (30 mg·kg FFC+400 mg·kg APS) drug combinations for 5 days. Read More

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November 2018

Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil.

Ecotoxicol Environ Saf 2018 Nov 27;169:696-706. Epub 2018 Nov 27.

Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-Ku, Sapporo, Japan.

Food Yellow 4 (FY4) is a lemon-yellow-colored synthetic organic azo dye, which is used widely for imparting pleasant and attractive appearance to foods and cosmetics. The present study aimed at evaluating the possible mechanism underlying the FY4-induced reprotoxicity in rats, and the potential supportive role of royal jelly (RJ) or cod liver oil (CLO), which is a natural remedy with several pharmacological benefits, against induced toxicity. Forty-eight male rats were divided into different groups-the control group, the CLO group (0. Read More

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November 2018
3 Reads

Associations between biochemical components of human semen with seminal conditions.

Syst Biol Reprod Med 2018 Nov 30:1-9. Epub 2018 Nov 30.

a Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.

The aim of the study was to assess whether abnormal levels of seminal biochemical components could be associated with semen alterations and infertility. In this study, 92 human ejaculates from selected men were analyzed. Albumin, estradiol, ferritin, total proteins (TP), folic acid (FA), vitamin B12, alkaline phosphatase (ALP), creatine kinase (CK), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase were evaluated. Read More

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November 2018
2 Reads

Internal medicine residents' achievement goals and efficacy, emotions, and assessments.

Can Med Educ J 2018 Nov 12;9(4):e59-e68. Epub 2018 Nov 12.

Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada.

Background: Achievement goal theory is consistently associated with specific cognitions, emotions, and behaviours that support learning in many domains, but has not been examined in postgraduate medical education. The purpose of this research was to examine internal medicine residents' achievement goals, and how these relate to their sense of self-efficacy, epistemic emotions, and valuing of formative compared to summative assessments. These outcomes will be important as programs transition more to competency based education that is characterized by ongoing formative assessments. Read More

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November 2018
4 Reads

Toxicity and biochemical effects of itol A on the brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae).

Pestic Biochem Physiol 2018 Nov 17;152:90-97. Epub 2018 Sep 17.

Guangxi Key Laboratory for Agro-Environment and Agro-Product Safety, Agricultural College, Guangxi University, Nanning 530004, Guangxi, People's Republic of China. Electronic address:

Itol A, a novel isoryanodane diterpene derived from Itoa orientalis Hemsl., has potent activities against insect pests. This study was conducted to determine the contact toxicity and biochemical effects of itol A on the Nilaparvata lugens. Read More

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November 2018

Improving health care transition and longitudinal care for adolescents and young adults with hydrocephalus: report from the Hydrocephalus Association Transition Summit.

Authors:

J Neurosurg 2018 Nov 1:1-9. Epub 2018 Nov 1.

The health care needs of children with hydrocephalus continue beyond childhood and adolescence; however, pediatric hospitals and pediatric neurosurgeons are often unable to provide them care after they become adults. Each year in the US, an estimated 5000-6000 adolescents and young adults (collectively, youth) with hydrocephalus must move to the adult health care system, a process known as health care transition (HCT), for which many are not prepared. Many discover that they cannot find neurosurgeons to care for them. Read More

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November 2018
1 Read

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Nat Commun 2018 11 28;9(1):5052. Epub 2018 Nov 28.

Medical Genomics Center, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. Read More

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November 2018

Advance care planning conversations with palliative patients: looking through the GP's eyes.

BMC Fam Pract 2018 Nov 28;19(1):184. Epub 2018 Nov 28.

Radboud Institute for Health Sciences, IQ healthcare, Radboud university medical center, Nijmegen, The Netherlands.

Background: Although it is often recommended that general practitioners (GPs) initiate advance care planning (ACP), little is known about their experiences with ACP. This study aimed to identify GP experiences when conducting ACP conversations with palliative patients, and what factors influence these experiences.

Methods: Dutch GPs (N = 17) who had participated in a training on timely ACP were interviewed. Read More

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November 2018
1 Read

Extender Unit Promiscuity and Orthogonal Protein Interactions of an Aminomalonyl-ACP Utilizing Trans-Acyltransferase from Zwittermicin Biosynthesis.

ACS Chem Biol 2018 Nov 28. Epub 2018 Nov 28.

Department of Chemistry , North Carolina State University , Raleigh , North Carolina 27695-8204 , United States.

Trans-acting acyltransferases (trans-ATs) are standalone enzymes that select and deliver extender units to polyketide synthase assembly lines. Accordingly, there is interest in leveraging trans-ATs as tools to regioselectively diversify polyketide structures. Yet, little is known regarding the extender unit and acyl carrier protein (ACP) specificity of trans-ATs, particularly those that utilize unusual ACP-linked extender units. Read More

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November 2018
1 Read

Safety and clinically important events in PCP-initiated STEMI bypass in Ottawa.

CJEM 2018 Nov;20(6):865-873

*Department of Emergency Medicine,University of Ottawa,Ottawa,ON.

CLINICIAN'S CAPSULE What is known about the topic? Transport of STEMI patients directly to the cath lab (STEMI bypass) by advanced care paramedics (ACPs) is common practice. The safety of this practice with primary care paramedics (PCPs) is unknown. What did this study ask? What is the prevalence and breakdown of events during PCP STEMI bypass? What did this study find? Clinically important events are common in STEMI bypass patients. Read More

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November 2018

[Impact assessment on enamel remineralization after orthodontic treatment with casein phosphopeptide calcium phosphate complex].

Shanghai Kou Qiang Yi Xue 2018 Aug;27(4):382-385

Department of Prosthodontics, Dalian Stomatological Hospital, Affiliated Stomatological Hospital of Dalian Medical University. Dalian 116021, China.

Purpose: To compare the effect on enamel demineralization following fluoride rinse or casein phosphopeptide calcium phosphate complex (CPP-ACP) after fixed appliance orthodontic treatment.

Methods: The study population consisted of 21 post-orthodontic patients (13 females, 8 males, 84 affected teeth) with white spot lesions (WSL). They were divided into 3 groups with 28 affected teeth in each group. Read More

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Effect of casein phosphopeptide-amorphous calcium phosphate on fluoride release and micro-shear bond strength of resin-modified glass ionomer cement in caries-affected dentin.

Restor Dent Endod 2018 Nov 30;43(4):e45. Epub 2018 Oct 30.

Dental Biomaterials Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

Objectives: This study was conducted to evaluate fluoride release and the micro-shear bond strength of resin-modified glass ionomer cement (RMGIC) in casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)-remineralized caries-affected dentin (CAD).

Materials And Methods: Exposed dentin surfaces of 30 human third molar teeth were divided into 2 equal groups for evaluating fluoride release and the micro-shear bond strength of RMGIC to CAD. Each group was subdivided into 3 equal subgroups: 1) control (sound dentin); 2) artificially demineralized dentin (CAD); 3) CPP-ACP remineralized dentin (remineralized CAD). Read More

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November 2018
2 Reads

Combination of left atrial appendage closure and catheter ablation in a single procedure for patients with atrial fibrillation: Multicenter experience.

J Formos Med Assoc 2018 Oct 25. Epub 2018 Oct 25.

Ningbo First Hospital, Zhejiang University, Ningbo, 315010, China.

Background/purpose: Experience in procedures combining left atrial appendage (LAA) closure (LAAC) and catheter ablation (CA) was scarce in Chinese nonvalvular atrial fibrillation (AF) patients with high risks for stroke and bleeding. We aimed to investigate the efficacy and safety of the combination therapy with LAAC and AF CA in a single procedure based on the multicenter data and medium-term follow-up results.

Methods: A total of 122 AF patients with a mean CHADS-VASc score of 4. Read More

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October 2018

Unexpected favorable role of Ca2+ in phosphate removal by using nanosized ferric oxides confined in porous polystyrene beads.

Environ Sci Technol 2018 Nov 27. Epub 2018 Nov 27.

Polystyrene-based nano-ferric oxide composite is a representative nanomaterial successfully applied in scale-up water decontamination for arsenic and phosphorous. However, little is available on the effect of solution chemistry (for instance, the coexisting Ca2+) on long-term performance of the nanocomposite. In this study, we carried out 20 cyclic runs of phosphate adsorption-desorption on a polymer-supported ferric nanocomposite HFO@201. Read More

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November 2018
2 Reads

Initiating Advance Care Planning in Primary Care: A Model for Success.

J Palliat Med 2018 Nov 27. Epub 2018 Nov 27.

3 Section of Palliative Care and Medical Ethics, Section of Treatment, Research, and Education in Addiction Medicine, Department of Medicine, Division of General Internal Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.

Background: Primary care physicians recognize the importance of advance care planning (ACP) conversations and report lack of training and time in the office to start them. Previous efforts have shown that ACP is a low-risk high-value intervention for older patients and those with life-limiting illness.

Objective: To measure the impact of physician coaching and staff training with registered nurse (RN) support and electronic medical record (EMR) enhancements on the initiation of 2000 ACP conversations in primary care. Read More

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November 2018
9 Reads

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients.

Innov Aging 2018 Jun 12;2(2):igy025. Epub 2018 Oct 12.

Golden Bioscience Communications.

In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a broad range of stakeholders invested in the care of older adults to focus on the topic of cognitive health and aging. Summit participants specifically examined questions of who should be screened for cognitive impairment and how they should be screened in medical settings. Read More

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June 2018
6 Reads

Experiences with approaches to advance care planning with older people: a qualitative study among Dutch general practitioners.

BMJ Open 2018 Nov 25;8(11):e024762. Epub 2018 Nov 25.

Section of Medical Ethics, Department of General Practice, Amsterdam Public Health research institute, Amsterdam University Medical Centres, Amsterdam, The Netherlands.

Objectives: Advance care planning (ACP) with older people needs to be approached differently than ACP with patients with a terminal illness. ACP is still used with only a minority of older patients due to a lack of knowledge regarding appropriate approaches to ACP with older people. General practitioners (GPs) may play a key role in ACP with older people. Read More

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November 2018
1 Read

Transcriptome analysis reveals a composite molecular map linked to unique seed oil profile of Neocinnamomum caudatum (Nees) Merr.

BMC Plant Biol 2018 Nov 26;18(1):303. Epub 2018 Nov 26.

School of Agriculture and Food Sciences, Zhejiang A & F University, Zhejiang, 311300, Hangzhou, China.

Background: Neocinnamomum caudatum (Nees) Merr., a biodiesel tree species in the subtropical areas of South China, India and Burma, is distinctive from other species in Lauraceae family and its seed oil is rich in linoleic acid (18:2) and stearic acid (18:0). However, there is little genetic information about this species so far. Read More

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November 2018

Principles for Patient and Family Partnership in Care: An American College of Physicians Position Paper.

Ann Intern Med 2018 Dec 27;169(11):796-799. Epub 2018 Nov 27.

David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California (P.G.).

In this position paper, the American College of Physicians (ACP) examines the rationale for patient and family partnership in care and reviews outcomes associated with this concept, including greater adherence to care plans, improved satisfaction, and lower costs. The paper also explores and acknowledges challenges associated with implementing patient- and family-centered models of care. On the basis of a comprehensive literature review and a multistakeholder vetting process, the ACP's Patient Partnership in Healthcare Committee developed a set of principles that form the foundation for authentic patient and family partnership in care. Read More

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December 2018
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Distribution and Variation of Bacterial Endosymbiont and "Candidatus Liberibacter asiaticus" Titer in the Huanglongbing Insect Vector, Diaphorina citri Kuwayama.

Microb Ecol 2018 Nov 24. Epub 2018 Nov 24.

Boyce Thompson Institute, Ithaca, NY, USA.

The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, is an economic insect pest in most citrus-growing regions and the vector of 'Candidatus Liberibacter asiaticus' (CLas), one of at least three known bacteria associated with Huanglongbing (HLB or citrus greening disease). D. citri harbors bacterial endosymbionts, including Wolbachia pipientis (strain Wolbachia wDi), 'Candidatus Carsonella ruddii,' and 'Candidatus Profftella armatura. Read More

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November 2018
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Palladium-catalyzed intramolecular transfer hydrogenation & cycloaddition of p-quinamine-tethered alkylidenecyclopropanes to synthesize perhydroindole scaffolds.

Chem Commun (Camb) 2018 Dec;54(100):14085-14088

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

A palladium(0)-catalyzed intramolecular transfer hydrogenation and cycloaddition of p-quinamine-tethered alkylidenecyclopropanes (ACPs) to synthesize perhydroindole scaffolds has been reported in this communication. Mechanistic investigations on the basis of deuterium labeling experiments suggest that the reaction proceeded through an oxidative addition of Pd(0) into the distal bond of the ACP moiety to afford a trimethylenemethane (TMM)-Pd intermediate followed by transfer hydrogenation using alcohol. Read More

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December 2018

FAmily CEntered (FACE) Advance Care Planning among African-American and non-African-American Adults Living with HIV in Washington, DC: A Randomized Controlled Trial to Increase Documentation & Health Equity.

J Pain Symptom Manage 2018 Nov 22. Epub 2018 Nov 22.

Division of Adolescent and Young Adult Medicine, Children's National, Center for Translational Science/Children's Research Institute, Washington, DC; George Washington University School of Medicine and Health Sciences, Washington, DC.

Context: No prospective studies address disease-specific Advance Care Planning (ACP) for adults living with HIV/AIDS.

Objective: To examine the efficacy of FAmily-CEntered (FACE) ACP in increasing advance care planning and advance directive documentation in the medical record.

Methods: Longitudinal, two-arm, randomized controlled trial with intent-to-treat design recruited from 5 hospital-based outpatient HIV clinics in Washington, DC. Read More

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November 2018
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Interventions Guiding Advance Care Planning Conversations: A Systematic Review.

J Am Med Dir Assoc 2018 Nov 22. Epub 2018 Nov 22.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: Advance care planning (ACP) is a communicative process of defining preferences for future medical care. Conversation guides support professionals to conduct ACP conversations, yet insight into essential components is limited.

Objectives: To evaluate the content, rationale, and empirical evidence on the effect of ACP interventions based on conversation guides. Read More

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November 2018
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Advanced Care Planning for Persons With Dementia in Primary Care: Attitudes and Barriers Among Health-Care Professionals.

J Palliat Care 2018 Nov 22:825859718812463. Epub 2018 Nov 22.

1 The Centre for Family Medicine Family Health Team, Kitchener, Ontario, Canada.

Background:: Advance care planning (ACP) provides clarity on goals and preferences for future health-care decisions, the timeliness of which is critical for persons with dementia.

Aim:: This study assessed Primary Care Collaborative Memory Clinic (PCCMC) health-care practitioners' desire for more education on ACP, capacity for and attitudes toward ACP, and current ACP practices in their regular family practice and in their PCCMC.

Methods:: Primary Care Collaborative Memory Clinic health-care professionals completed a questionnaire in which they rated their interest in learning various ACP-related topics (5-point scale: not at all to very much so), attitudes toward ACP, and the importance of and perceived degree of responsibility for ACP (5-point scale: not at all to extremely). Read More

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November 2018
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Barriers to Promoting Advance Care Planning for Residents Living in a Sanatorium for Hansen's Disease: A Qualitative Study of Residents and Staff in Japan.

Asian Bioeth Rev 2018 3;10(3):199-217. Epub 2018 Aug 3.

2Advanced Research Center for Human Sciences, Waseda University, Tokyo, Japan.

In Japan, most residents with Hansen's disease (leprosy) live in dedicated sanatoria because of an established quarantine policy, even after being cured of the primary disease. They suffer from secondary diseases and are advancing in age, and advance care planning (ACP) is increasingly crucial for them to live their lives with dignity in a sanatorium. In this study, we have three aims: (1) to understand how to promote communication about their wishes for medical treatment, care, and recuperation; (2) to identify required assistance; and (3) to explore how to promote ACP in a sanatorium. Read More

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August 2018
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