20,378 results match your criteria ACC Cardiosource Review Journal CRJ[Journal]


Energy Flux Manipulation in Upconversion Nanosystems.

Acc Chem Res 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, Faculty of Science , National University of Singapore , Singapore 117543.

Lanthanide-doped upconversion nanoparticles (UCNPs) exhibit unique optical characteristics, including a large anti-Stokes shift, a long luminescence lifetime, sharp emission bands, and high photostability. These virtues make UCNPs highly useful in many emerging applications such as biolabeling, security, multicolor displays, and optogenetics. Despite the enticing prospects of UCNPs, their practical utility is greatly hindered by the low efficiency of the conversion from near-infrared (NIR) excitation to visible emission. Read More

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December 2018

Characterising the hypertolerance potential of two indigenous bacterial strains (Bacillus flexus and Acinetobacter junii) and their efficacy in arsenic bioremediation.

J Appl Microbiol 2018 Dec 17. Epub 2018 Dec 17.

Plant Ecology and Environmental Sciences, CSIR- National Botanical Research Institute, Rana Pratap Marg, Lucknow, 226001, India.

Aims: The aims of the study were to (1) isolate and characterize arsenic tolerant bacterial strains (2) study the plant growth promoting (PGP) traits (3) explore their bioremediation potential.

Methods And Results: Indigenous arsenic hypertolerant bacterial isolates NM02 and NM03 were screened as they were capable of growing at 150 mmol l As (V) and 70 mmol l As (III). They were identified on the basis of morphological, physiological and biochemical parameter and 16sDNA sequence as Bacillus flexus and Acinetobacter junii, respectively. Read More

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December 2018

A Longitudinal Multimodal Neuroimaging Study to Examine Relationships Between Resting State Glutamate and Task Related BOLD Response in Schizophrenia.

Front Psychiatry 2018 29;9:632. Epub 2018 Nov 29.

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United States.

Previous studies have observed impairments in both brain function and neurometabolite levels in schizophrenia. In this study, we investigated the relationship between brain activity and neurochemistry in off-medication patients with schizophrenia and if this relationship is altered following antipsychotic medication by combining proton magnetic resonance spectroscopy (1H-MRS) with functional magnetic resonance imaging (fMRI). We used single voxel MRS acquired in the bilateral dorsal anterior cingulate cortex (ACC) and fMRI during performance of a Stroop color-naming task in 22 patients with schizophrenia (SZ), initially off-medication and after a 6-week course of risperidone, and 20 matched healthy controls (HC) twice, 6 weeks apart. Read More

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November 2018

Regulatory Efficacy of Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Lipid metabolism disorder (LMD) is a public health issue. is a widely used natural weight-reducing agent and is a kind of protein source. In the present study, we aimed to evaluate the effect of protease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Read More

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December 2018

F-FDG PET/MRI vs MRI in patients with recurrent adenoid cystic carcinoma.

Head Neck 2018 Dec 13. Epub 2018 Dec 13.

Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Objectives: To evaluate and compare the diagnostic potential of F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ( FDG-PET/MRI) and MRI for recurrence diagnostics after primary therapy in patients with adenoid cystic carcinoma (ACC).

Methods: A total of 32 dedicated head and neck F-FDG PET/MRI datasets were included in this analysis. MRI and F-FDG PET/MRI datasets were analyzed in separate sessions by two readers for tumor recurrence or metastases. Read More

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December 2018

Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.

Hum Brain Mapp 2018 Dec 12. Epub 2018 Dec 12.

Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Research on age-related memory alterations traditionally targets individuals aged ≥65 years. However, recent studies emphasize the importance of early aging processes. We therefore aimed to characterize variation in brain gray matter structure in early midlife as a function of sex and menopausal status. Read More

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December 2018

MicroRNA-217 relieved neuropathic pain through targeting toll-like receptor 5 expression.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Neuropathic pain is the most common chronic pain that is caused by nerve injury or disease that influences the nervous system. Increasing evidence suggested that microRNAs (miRNAs) play a crucial role in neuropathic pain and neuroinflammation development. However, the functional role of miR-217 in the development of neuropathic pain remains unknown. Read More

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December 2018

Growth-Rule-Guided Structural Exploration of Thiolate-Protected Gold Nanoclusters.

Acc Chem Res 2018 Dec 14. Epub 2018 Dec 14.

College of Chemistry, Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education , Xiangtan University , Xiangtan , Hunan 411105 , China.

Understanding the structure and structure-property relationship of atomic and ligated clusters is one of the central research tasks in the field of cluster research. In chemistry, empirical rules such as the polyhedral skeleton electron pair theory (PSEPT) approach had been outlined to account for skeleton structures of many main-group atomic and ligand-protected transition metal clusters. Nonetheless, because of the diversity of cluster structures and compositions, no uniform structural and electronic rule is available for various cluster compounds. Read More

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December 2018

Frontostriatal grey matter atrophy in amyotrophic lateral sclerosis A visual rating study.

Dement Neuropsychol 2018 Oct-Dec;12(4):388-393

Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.

Amyotrophic lateral sclerosis (ALS) is characterised by frontostriatal grey matter changes similar to those in frontotemporal dementia (FTD). However, these changes are usually detected at a group level, and simple visual magnetic resonance imaging (MRI) cortical atrophy scales may further elucidate frontostriatal changes in ALS.

Objective: To investigate whether frontostriatal changes are detectable using simple visual MRI atrophy rating scales applied at an individual patient level in ALS. Read More

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December 2018

Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.

Mol Metab 2018 Nov 28. Epub 2018 Nov 28.

Division of Neurodegenerative Disorders, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada. Electronic address:

Objective: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of animal models of type 1 and type 2 diabetes. We hypothesized that sub-optimal insulin-like growth factor 1 (IGF-1) signaling in diabetes drives loss of AMPK activity and mitochondrial function, both contributing to development of DSPN. Read More

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November 2018
1 Read

The early prognostic value of inflammatory markers in patients with acute pancreatitis.

Clin Res Hepatol Gastroenterol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan city, Hubei province 430060, PR China. Electronic address:

Objectives: The aim of this study was to compare the prognostic value of inflammation-based prognostic markers with the more mature scoring system BISAP in patients with AP and identify the best predictors.

Patients And Methods: We retrospectively analysed the data of patients with AP who were treated in our hospital from January 2017 to March 2018 and compared the prognostic value of these inflammation-based prognostic markers with the BISAP score in patients with AP.

Results: Higher BISAP score, NLR, PLR, ACC, and BUN gradually increased (all P < 0. Read More

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December 2018
1 Read

Complete remission after hypofractionated radiotherapy for a patient with inoperable adenoid cystic carcinoma of bronchus: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13463

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Tracheobronchial adenoid cystic carcinoma (TACC) is a rare malignancy. Surgical resection remains the standard treatment of choice. But it is frequently unresectable due to its local extension. Read More

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December 2018
1 Read

The Middle Road Less Taken: Electronic-Structure-Inspired Design of Hybrid Photocatalytic Platforms for Solar Fuel Generation.

Acc Chem Res 2018 Dec 13. Epub 2018 Dec 13.

Departments of Chemistry and Materials Science and Engineering , Texas A&M University , College Station , Texas 77842-3012 , United States.

The development of efficient solar energy conversion to augment other renewable energy approaches is one of the grand challenges of our time. Water splitting, or the disproportionation of HO into energy-dense fuels, H and O, is undoubtedly a promising strategy. Solar water splitting involves the concerted transfer of four electrons and four protons, which requires the synergistic operation of solar light harvesting, charge separation, mass and charge transport, and redox catalysis processes. Read More

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December 2018

ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting.

J Neurodev Disord 2018 Dec 13;10(1):34. Epub 2018 Dec 13.

Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, 21205, USA.

Background: Attention-deficit/hyperactivity disorder (ADHD) is associated with atypical fronto-subcortical neural circuitry and heightened delay discounting, or a stronger preference for smaller, immediate rewards over larger, delayed rewards. Recent evidence of ADHD-related sex differences in brain structure and function suggests anomalies in fronto-subcortical circuitry may differ among girls and boys with ADHD. The current study examined whether the functional connectivity (FC) within fronto-subcortical neural circuitry differs among girls and boys with ADHD compared to same-sex typically developing (TD) controls and relates to delay discounting. Read More

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December 2018

CardioMEMS in a Busy Cardiology Practice: Less than Optimal Implementation of a Valuable Tool to Reduce Heart Failure Readmissions.

Cardiol Res Pract 2018 7;2018:4918757. Epub 2018 Nov 7.

Providence Hospital, Michigan State University, Detroit, MI, USA.

Introduction: Congestive heart failure is a leading cause of cardiovascular morbidity and mortality that results in a significant financial burden on healthcare expenditure. Though various strategies have been employed to reduce hospital readmissions, one valuable tool that remains greatly underutilized is the CardioMEMS (), a remote pulmonary artery pressure-monitoring system, which has been shown to help reduce heart failure rehospitalizations in the CHAMPION (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients) trial.

Methods: ICD-9/ICD-10 codes for chronic heart failure were used to identify patients who presented with congestive heart failure. Read More

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November 2018

Electroacupuncture Mitigates Skeletal Muscular Lipid Metabolism Disorder Related to High-Fat-Diet Induced Insulin Resistance through the AMPK/ACC Signaling Pathway.

Evid Based Complement Alternat Med 2018 7;2018:7925842. Epub 2018 Nov 7.

Traditional Therapy Department of Fangchun, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

The aim of this work is to investigate the effect of electroacupuncture (EA) on insulin sensitivity in high-fat diet (HFD) induced insulin resistance (IR) rats and to evaluate expression of AMPK/ACC signaling components. Thirty-two male Sprague-Dawley rats were randomized into control group, HFD group, HFD+Pi (oral gavage of pioglitazone) group, and HFD+EA group. Acupuncture was subcutaneously applied to Zusanli (ST40) and Sanyinjiao (SP6). Read More

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November 2018

Deep learning in the cross-time-frequency domain for sleep staging from a single lead electrocardiogram.

Physiol Meas 2018 Nov 23. Epub 2018 Nov 23.

Department of Biomedical Informatics, Emory University, 36 Eagle Row, #571, MS 2045-001-1AC, Atlanta, GA 30322, Atlanta, Georgia, UNITED STATES.

Objective: This study classifies sleep stages from a single lead electrocardiogram (ECG) using beat detection, cardiorespiratory coupling in the time-frequency domain and a deep convolutional neural network (CNN). Approach: An ECG-derived respiration (EDR) signal and synchronous beat-to-beat heart rate variability (HRV) time series were derived from the ECG using previously described robust algorithms. A measure of cardiorespiratory coupling (CRC) was extracted by calculating the coherence and cross-spectrogram of the EDR and HRV signal in five-minute windows. Read More

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November 2018

Bart's Syndrome with Novel Frameshift Mutations in the COL7A1 Gene.

Fetal Pediatr Pathol 2018 Dec 7:1-8. Epub 2018 Dec 7.

c Department of Dermatology , Pusan National University Yangsan Hospital , Yangsan , Republic of Korea.

Introduction: Bart's syndrome, a hereditary mechanobullous disorder characterized by aplasia cutis congenita (ACC) with epidermolysis bullosa (EB), has not been genotyped frequently.

Case Report: A full-term female neonate had well-demarcated absence of skin on both legs at birth, with blisters and erosive patches developing immediately after birth. Electron microscopy showed blister formation under the lamina densa layer. Read More

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December 2018

ACC/AHA Versus ESC Guidelines on Dual Antiplatelet Therapy: JACC Guideline Comparison.

J Am Coll Cardiol 2018 Dec;72(23 Pt A):2915-2931

Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida. Electronic address:

Dual antiplatelet therapy (DAPT) is the cornerstone of pharmacological treatment aimed at preventing the atherothrombotic complications in patients with a variety of coronary artery disease (CAD) manifestations. Prescribers of DAPT are confronted with a number of challenges that include selecting the appropriate P2Y inhibitor and determining the optimal duration of DAPT with the scope of minimizing the risk of ischemic and bleeding complications in light of each patient's clinical characteristic and circumstance. Recently, a guideline writing committee from the American College of Cardiology/American Heart Association (ACC/AHA) and a task force from the European Society of Cardiology (ESC) released their respective focused update recommendations on "Duration of DAPT in Patients with CAD" (ACC/AHA) and "DAPT in CAD" (ESC). Read More

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December 2018
1 Read

Roles of Ventromedial Prefrontal Cortex and Anterior Cingulate in Subjective Valuation of Prospective Effort.

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Engineering, Johns Hopkins School of Medicine, 773 North Broadway, Baltimore, MD, USA.

The perceived effort level of an action shapes everyday decisions. Despite the importance of these perceptions for decision-making, the behavioral and neural representations of the subjective cost of effort are not well understood. While a number of studies have implicated anterior cingulate cortex (ACC) in decisions about effort/reward trade-offs, none have experimentally isolated effort valuation from reward and choice difficulty, a function that is commonly ascribed to this region. Read More

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December 2018
1 Read

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

PLoS One 2018 12;13(12):e0208757. Epub 2018 Dec 12.

Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.

Premature baboons exhibit peripheral insulin resistance and impaired insulin signaling. 5' AMP-activated protein kinase (AMPK) activation improves insulin sensitivity by enhancing glucose uptake (via increased glucose transporter type 4 [GLUT4] translocation and activation of the extracellular signal-regulated kinase [ERK]/ atypical protein kinase C [aPKC] pathway), and increasing fatty acid oxidation (via inhibition of acetyl-CoA carboxylase 1 [ACC]), while downregulating gluconeogenesis (via induction of small heterodimer partner [SHP] and subsequent downregulation of the gluconeogenic enzymes: phosphoenolpyruvate carboxykinase [PEPCK], glucose 6-phosphatase [G6PASE], fructose- 1,6-bisphosphatase 1 [FBP1], and forkhead box protein 1 [FOXO1]). The purpose of this study was to investigate whether pharmacologic activation of AMPK with AICAR (5-aminoimidazole-4-carboximide riboside) administration improves peripheral insulin sensitivity in preterm baboons. Read More

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December 2018

Single-Atom Alloys as a Reductionist Approach to the Rational Design of Heterogeneous Catalysts.

Acc Chem Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry , Tufts University , 62 Talbot Avenue , Medford , Massachusetts 02155 United States.

Heterogeneous catalysts are workhorses in the industrial production of most commodity and specialty chemicals, and have widespread energy and environmental applications, with the annual market value of the catalysts themselves reaching almost $20 billion in 2018. These catalysts are complex, comprising multicomponent materials and multiple structures, making their rational design challenging, if not impossible. Furthermore, typical active metals like Pt, Pd, and Rh are expensive and can be susceptible to poisoning by CO, coking, and they are not always 100% selective. Read More

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December 2018
2 Reads

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objective: Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.

Methods: In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Read More

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December 2018

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

Cell Mol Gastroenterol Hepatol 2018 Sep 15;7(1):197-209. Epub 2018 Sep 15.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background & Aims: Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators after liver injury. The aim of this study was to analyze the epigenetic modulators that differentially control TGF-β and PDGF signaling pathways. Read More

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September 2018

Blast furnace flue dust co-processing in cement kiln - A pilot study.

Waste Manag Res 2018 Dec 11:734242X18816791. Epub 2018 Dec 11.

2 Geocycle India, ACC Limited, Thane Complex, LBS Marg, Thane, India.

An integrated steel plant generates a large amount of blast furnace flue dust - about 18-22 kg/t of hot metal - as a by-product of the production process. The major component of this flue dust is iron oxides and coke fines. The recovery and reuse of this iron and coke is very important with increasing price of conventional resources. Read More

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December 2018

Developing a quality standard for verbal communication during CABG procedures.

Semin Thorac Cardiovasc Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardio-Thoracic Surgery, Leiden University Medical Center, Leiden.

Objective: Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The goal of this study was to improve communication during CABG by identifying critical items in verbal interaction between surgeons, anesthetists and perfusionists.

Methods: Based on 6 video recordings, a list was assembled containing items of communication in CABG procedures. Read More

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December 2018
1 Read

Pioneers in neurology: Michel Jouvet (1925-2017).

J Neurol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, ACC 708, Boston, MA, 02114, USA.

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December 2018

Reward improves response inhibition by enhancing attentional capture.

Soc Cogn Affect Neurosci 2018 Dec 7. Epub 2018 Dec 7.

Southwest University, Key Laboratory of Cognition and Personality of Ministry of Education.

Reward plays a crucial role in enhancing response inhibition. While it is generally assumed that the process of response inhibition involves attentional capture and the stopping of action, it is unclear whether this reflects a direct impact of reward on response inhibition or rather an indirect mediation via attentional capture. Here, we employed a revised stop-signal task (SST) that explicitly distinguished between these processes, by including a Continue signal that required the same motor response as in Go trials, but also attention to a cue, as in Stop trials. Read More

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December 2018
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Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

The von Economo neurons (VENs) are specialized large bipolar projection neurons with restricted distribution in the human brain, and they are far more abundant in humans than in non-human primates. However, VEN functions remain elusive due to the difficulty of isolating VENs and dissecting their connections in the brain. Here, we combined laser-capture-microdissection with RNA sequencing to describe the transcriptomic profile of VENs from human anterior cingulate cortex (ACC). Read More

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December 2018

Structural Connectivity of the Anterior Cingulate Cortex, Claustrum, and the Anterior Insula of the Mouse.

Front Neuroanat 2018 26;12:100. Epub 2018 Nov 26.

Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States.

The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. The function of the claustrum is not fully described, and while our previous work supports a role for the claustrum in top-down cognitive control of action, other evidence suggests the claustrum may be involved in detecting salient changes in the external environment. The anterior cingulate cortex (ACC) and the anterior insular (aINS) are the two major participants in the salience network of human brain regions that activate in response to salient stimuli. Read More

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November 2018

Upregulation of autophagy by Ginsenoside Rg2 in MCF-7 cells.

Anim Cells Syst (Seoul) 2018 19;22(6):382-389. Epub 2018 Nov 19.

Division of Biological Sciences, Wonkwang University, Iksan, Republic of Korea.

Autophagy is a major intracellular degradation process that plays an important role in cell survival, stress responses, nutrient sensing and development. Our previous studies have shown that Rg2, a triterpenoid saponin contained in ginseng, protects cells against UVB-induced genotoxicity by increasing DNA repair, in possible association with modulation of protein levels involved in p53 pathway. In this study, we determined an upregulation of autophagy by Rg2. Read More

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November 2018
1 Read
0.440 Impact Factor

Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study.

Endocr Connect 2018 Dec;7(12):1409-1414

Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France.

Background The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug-drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a substrate of CYP3A4, may contribute to chemoresistance. The aim of this pilot study was to assess the pharmacokinetic interaction between mitotane and etoposide in ACC patients. Read More

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December 2018

Children With Dyslexia and Typical Readers: Sex-Based Choline Differences Revealed Using Proton Magnetic Resonance Spectroscopy Acquired Within Anterior Cingulate Cortex.

Front Hum Neurosci 2018 23;12:466. Epub 2018 Nov 23.

Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Children with dyslexia exhibit slow and inaccurate reading, as well as problems in executive functions. Decreased signal activation in brain regions related to visual processing and executive functions has been observed with functional magnetic resonance imaging with reports of sex differences in brain patterns for visual processing regions. However, the underlying neurochemistry associated with deficits in executive functions for children with dyslexia has not been thoroughly evaluated. Read More

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November 2018

Modulating Effects of Contextual Emotions on the Neural Plasticity Induced by Word Learning.

Front Hum Neurosci 2018 23;12:464. Epub 2018 Nov 23.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.

Recently, numerous studies have investigated the neurocognitive mechanism of learning words in isolation or in semantic contexts. However, emotion as an important influencing factor on novel word learning has not been fully considered in the previous studies. In addition, the effects of emotion on word learning and the underlying neural mechanism have not been systematically investigated. Read More

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November 2018
1 Read

Inhaler technique education and asthma control among patients hospitalized for asthma in Jordan.

Saudi Pharm J 2018 Dec 7;26(8):1127-1136. Epub 2018 Jul 7.

Woolcock Institute of Medical Research, University of Sydney, NSW, Australia.

Objectives: To investigate the effect of inhaler technique education delivered by a clinical pharmacist to patients hospitalised for asthma, on inhaler technique scores and asthma control at three months post-discharge.

Methods: This pre-post interventional study in Jordan enrolled patients who had been admitted for asthma and were using controller medication by Accuhaler [Diskus] (ACC), Turbuhaler (TH) or Pressurized metered dose inhalers (pMDI). Inhaler technique was assessed using published checklists (score 0-9). Read More

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December 2018
2 Reads

Development and Application of a Risk Prediction Model for In-Hospital Stroke After Transcatheter Aortic Valve Replacement - A Report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

University of Florida College of Medicine-Jacksonville, Jacksonville, FL.

Background: Stroke is a serious complication following transcatheter aortic valve replacement (TAVR), yet predictive models are not available. A new risk model for in-hospital stroke following TAVR was developed and used to estimate site-specific performance.

Methods: We included 97,600 TAVR procedures from 521 sites in the STS/ACC Transcatheter Valve Therapy (TVT) Registry from July 2014 through June 2017. Read More

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December 2018

Increased burden of coronary artery calcium from elevated blood pressure in low-risk young adults.

Atherosclerosis 2018 Dec 1. Epub 2018 Dec 1.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address:

Background And Aims: The relationship between blood pressure (BP) levels given in the new hypertension guidelines by the American College of Cardiology and the American Heart Association (ACC/AHA) and subclinical coronary atherosclerosis in low-risk young adults is unknown. We evaluated the association between the new BP categories and coronary artery calcium (CAC) in low-risk, young and middle-aged adults.

Methods: We performed a cross-sectional study of 96,166 Koreans who underwent a health examination including cardiac tomography estimation of CAC scores in 2012-2017. Read More

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December 2018

Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

Neuron 2018 Nov 30. Epub 2018 Nov 30.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK. Electronic address:

Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific subregions remain unidentified. We addressed these issues by combining intracerebral microinfusions with cardiovascular and behavioral monitoring in marmoset monkeys to show that over-activation of primate subgenual anterior cingulate cortex (sgACC, area 25) blunts appetitive anticipatory, but not consummatory, arousal, whereas manipulations of adjacent perigenual ACC (pgACC, area 32) have no effect. Read More

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November 2018

New Challenges for Treatment in Hypertension.

Arch Med Res 2018 Dec 4. Epub 2018 Dec 4.

Programa "A todo corazón", Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

In Mexico around 22.3 million adult Mexicans have hypertension. An estimated 65 million adult Americans, or nearly one in four of the adult population of the United States, have hypertension. Read More

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December 2018

Implementation of a research capstone course with expanded flexibility.

Curr Pharm Teach Learn 2019 Jan 2;11(1):81-86. Epub 2018 Oct 2.

Department of Pharmacy and Health Systems Sciences, School of Pharmacy, Mail Stop R218 TF Northeastern University, 360 Huntington Avenue, Boston, MA 02115 United States. Electronic address:

Background And Purpose: A research-focused capstone course was designed to improve flexibility in the way pharmacy students meet the university's capstone requirement. The requirement aims to integrate knowledge, skills, and attitudes from didactic coursework and to apply them in a scholarly way to improve critical and evidence-based thinking, communication skills, and professionalism. This report describes the capstone course and faculty and student perceptions after the first year of implementation. Read More

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January 2019
1 Read

UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Oral Oncol 2018 Dec 18;87:21-28. Epub 2018 Oct 18.

Department of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI, USA; Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objectives: Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line.

Material And Methods: Immediately after surgery, a tumor fragment from a minor salivary gland from the tongue of a female Caucasian was minced, dissociated, and a single cell suspension was plated in fibronectin-coated flasks. Read More

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December 2018

Clinical, pathological and treatment factors associated with the survival of patients with primary pulmonary salivary gland-type tumors.

Lung Cancer 2018 Dec 10;126:174-181. Epub 2018 Nov 10.

Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, 200072, China. Electronic address:

Introduction: Primary pulmonary salivary gland-type tumors (p-SGTs) are rare, with poorly understood clinicopathological characteristics and survival. There are only few case reports or small case series, and factors associated with survival need to be identified.

Methods: A population cohort study was conducted using data from patients with histologically diagnosed primary p-SGTs in the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. Read More

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December 2018
3.958 Impact Factor

A Population-Based Study of Adherence to Guideline Recommendations and Appropriate-Use Criteria for Implantable Cardioverter Defibrillators.

Can J Cardiol 2018 Dec 24;34(12):1677-1681. Epub 2018 Aug 24.

Mazankowski Alberta Heart Institute, University of Alberta, Division of Cardiology, Edmonton, Alberta, Canada. Electronic address:

Studies evaluating physician adherence to guideline recommendations for implantable cardioverter defibrillator (ICD) therapy are sparse, and none exist for the application of appropriate-use criteria (AUC) in clinical practice. As part of a quality improvement initiative, a review of all ICD procedures was performed from January 1, 2015 to December 31, 2016 in Alberta, Canada, to evaluate the proportion of patients receiving appropriate ICD therapy and to identify reasons for nonadherence. Our device-implant process involves an electrophysiologist or implanting cardiologist evaluation, reminders of ICD eligibility criteria on the device requisition, and peer-review consensus. Read More

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December 2018

Arterial stiffness and subclinical aortic damage of reclassified subjects as stage 1 hypertension according to the new 2017 ACC/AHA blood pressure guidelines.

Vasa 2018 Dec 10:1-8. Epub 2018 Dec 10.

1 First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: The 2017 ACC/AHA blood pressure (BP) guidelines generated controversies due to the new proposed BP cut-off values defining hypertension. We aimed to assess aortic stiffness of subjects who are reclassified as stage 1 hypertensive according to the new guidelines and compare them with the subjects of "elevated BP" category.

Patients And Methods: Data from the "Corinthia" study, an observational, cross-sectional survey of 2,043 participants were analyzed. Read More

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December 2018

Materials and Designs for Power Supply Systems in Skin-Interfaced Electronics.

Acc Chem Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Materials Science and Engineering , Northwestern University , Evanston , Illinois 60208 , United States.

Recent advances in materials chemistry and composite materials design establish the foundations for classes of electronics with physical form factors that bridge the gap between soft biological organisms and rigid microsystems technologies. Skin-interfaced platforms of this type have broad utility in continuous clinical-grade monitoring of physiological status, with the potential to significantly lower the cost and increase the efficacy of modern health care. Development of materials and device designs for power supply systems in this context is critically important, and it represents a rapidly expanding focus of research in the chemical sciences. Read More

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December 2018

Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity.

Acc Chem Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemistry , Yale University , P.O. Box 208107, New Haven , Connecticut 06520-8107 , United States.

Nature's catalytic machinery has provided endless inspiration for chemists. While the enzymatic ideal has yet to be fully realized, the field has made tremendous strides toward synthetic, small-molecule catalysts for a wide array of transformations, often drawing upon biological concepts in their design. One strategy that has been particularly influenced by enzymology is peptide catalysis, wherein oligopeptides are implemented as chiral catalysts in synthetically relevant reactions. Read More

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December 2018

Disruption and overexpression of the gene encoding ACC (1-aminocyclopropane-1-carboxylic acid) deaminase in soil-borne fungal pathogen Verticillium dahliae revealed the role of ACC as a potential regulator of virulence and plant defense.

Mol Plant Microbe Interact 2018 Dec 6. Epub 2018 Dec 6.

Cyprus University of Technology, Agricultural Sciences, Biotechnology and Food Science , PO BOX 50329 , LIMASSOL , LIMASSOL, Cyprus , 2036.

It has been suggested that some microorganisms, including plant growth promoting rhizobacteria (PGPR), manipulate the level of ethylene in plants by degrading 1-aminocyclopropane-1-carboxylic acid (ACC), an ethylene precursor, into α-ketobutyrate and ammonia using ACC deaminase. Here, we investigated whether ACC deaminase of Verticillium dahliae, a soil-borne fungal pathogen of many important crops, is involved in causing vascular wilt disease. Overexpression of the V. Read More

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December 2018

Emerging Design and Characterization Guidelines for Polymer-Based Infrared Photodetectors.

Acc Chem Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Electrical and Computer Engineering , University of California San Diego , 9500 Gilman Drive , La Jolla , California 92093-0407 , United States.

Infrared photodetectors are essential to many applications, including surveillance, communications, process monitoring, and biological imaging. The short-wave infrared (SWIR) spectral region (λ = 1-3 μm) is particularly powerful for health monitoring and medical diagnostics because biological tissues show low absorbance and minimal SWIR autofluorescence, enabling greater penetration depth and improved resolution in comparison with visible light. However, current SWIR photodetection technologies are largely based on epitaxially grown inorganic semiconductors, which are costly, require complex processing, and impose cooling requirements incompatible with wearable electronics. Read More

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December 2018
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