23,177 results match your criteria ACC Cardiosource Review Journal CRJ[Journal]


Post-ictal accelerometer silence as a marker of post-ictal immobility.

Epilepsia 2020 May 27. Epub 2020 May 27.

Division of Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Objective: Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complications and with sudden unexpected death in epilepsy (SUDEP). Read More

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http://dx.doi.org/10.1111/epi.16552DOI Listing

Age-Related Changes in Pain Perception Are Associated With Altered Functional Connectivity During Resting State.

Front Aging Neurosci 2020 7;12:116. Epub 2020 May 7.

Cognitive and Affective Neuroscience and Clinical Psychology, Research Institute of Health Sciences (IUNICS) and Balearic Islands Health Research Institute (IdISBa), University of the Balearic Islands (UIB), Palma, Spain.

Aging affects pain experience and brain functioning. However, how aging leads to changes in pain perception and brain functional connectivity has not yet been completely understood. To investigate resting-state and pain perception changes in old and young participants, this study employed region of interest (ROI) to ROI resting-state functional connectivity (rsFC) analysis of imaging data by using regions implicated in sensory and affective dimensions of pain, descending pain modulation, and the default-mode networks (DMNs). Read More

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http://dx.doi.org/10.3389/fnagi.2020.00116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221150PMC

Cave bacteria-induced amorphous calcium carbonate formation.

Sci Rep 2020 May 26;10(1):8696. Epub 2020 May 26.

Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117, Budapest, Hungary.

Amorphous calcium carbonate (ACC) is a precursor of crystalline calcium carbonates that plays a key role in biomineralization and polymorph evolution. Here, we show that several bacterial strains isolated from a Hungarian cave produce ACC and their extracellular polymeric substance (EPS) shields ACC from crystallization. The findings demonstrate that bacteria-produced ACC forms in water-rich environment at room temperature and is stable for at least half year, which is in contrast to laboratory-produced ACC that needs to be stored in a desiccator and kept below 10 °C for avoiding crystallization. Read More

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http://dx.doi.org/10.1038/s41598-020-65667-wDOI Listing

Beyond Forcing Scenarios: Predicting Climate Change through Response Operators in a Coupled General Circulation Model.

Sci Rep 2020 May 26;10(1):8668. Epub 2020 May 26.

Laboratoire de Physique, ENS de Lyon, Université Claude Bernard, Université Lyon, CNRS, Lyon, F-69342, France.

Global Climate Models are key tools for predicting the future response of the climate system to a variety of natural and anthropogenic forcings. Here we show how to use statistical mechanics to construct operators able to flexibly predict climate change. We perform our study using a fully coupled model - MPI-ESM v. Read More

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http://dx.doi.org/10.1038/s41598-020-65297-2DOI Listing

Glucose and lipid metabolism of broiler chickens fed diets with graded levels of corn resistant starch.

Br Poult Sci 2020 May 27. Epub 2020 May 27.

College of Animal Science and Technology, Jiangsu Provincial Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Provincial Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Joint International Research Laboratory of Animal Health and Food Safety, National Experimental Teaching Demonstration Center of Animal Science, Nanjing Agricultural University , Nanjing 210095, China.

1. The aim of this study was to investigate the effects of graded levels of dietary corn resistant starch (RS) on glucose and lipid metabolism of broilers. 2. Read More

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http://dx.doi.org/10.1080/00071668.2020.1774511DOI Listing

Assessment of the Efficacy and Safety of Ivy Leaf () Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis.

Evid Based Complement Alternat Med 2020 4;2020:1910656. Epub 2020 May 4.

Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland.

Introduction: Acute bronchitis is defined as a sudden inflammation of the bronchial tubes in the lung mainly caused by viral infection. It is characterized by a persistent cough which can be productive or dry. It is the most common disease in industrialized countries, and thus herbal expectorants enjoy a high popularity in many European countries due to their favorable risk-benefit ratio. Read More

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http://dx.doi.org/10.1155/2020/1910656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222538PMC

An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells.

Bioorg Chem 2020 May 18;100:103935. Epub 2020 May 18.

Instituto de Química de Recursos Naturales, Universidad de Talca, Chile; Network for Snake Venom Research and Drug Discovery, Santiago, Chile. Electronic address:

Since cancer cells have different mitochondrial bioenergetic requirements than non-cancerous cells, therapeutic inhibition of its mitochondrial functionality continues to be an important target for anticancer drug discovery. In this study, a series of acylhydroquinones with different acyl-chain length, and their chlorinated derivatives, in the aromatic ring, synthesized by Fries rearrangement under microwave irradiation, were evaluated for their anticancer activity in two leukemia cell lines. Findings from the primary and secondary screening of the 18 acylhydroquinones, tested at 5 µM on acute promyelocytic leukemia HL-60 and acute lymphoblastic leukemia CEM cells lines, identified an acylchlorohydroquinone (12) with a highly selective anti-proliferative effect toward HL-60 cells. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103935DOI Listing

Intermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice.

J Neuroinflammation 2020 May 25;17(1):163. Epub 2020 May 25.

Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.

Background: Consecutive peripheral immune challenges can modulate the responses of brain resident microglia to stimuli. High-fat diet (HFD) intake has been reported to stimulate the activation of astrocytes and microglia in the arcuate nucleus (ARC) of the hypothalamus in obese rodents and humans. However, it is unknown whether intermittent exposure to additional peripheral immune challenge can modify HFD-induced hypothalamic glial activation in obese individuals. Read More

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http://dx.doi.org/10.1186/s12974-020-01837-xDOI Listing

External validation of existing prediction models of 30-day mortality after Transcatheter Aortic Valve Implantation (TAVI) in the Netherlands Heart Registration.

Int J Cardiol 2020 May 22. Epub 2020 May 22.

Department of Medical Informatics, Amsterdam UMC - Location AMC, University of Amsterdam, the Netherlands.

Background: Several mortality prediction models (MPM) are used for predicting early (30-day) mortality following transcatheter aortic valve implantation (TAVI). Little is known about their predictive performance in external TAVI populations. We aim to externally validate established MPMs on a large TAVI dataset from the Netherlands Heart Registration (NHR). Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.05.039DOI Listing

Homeobox transcription factor OsZHD2 promotes root meristem activity in rice by inducing ethylene biosynthesis.

J Exp Bot 2020 May 25. Epub 2020 May 25.

Crop Biotech Institute and Graduate School of Biotechnology, Kyung Hee University, Yongin, Korea.

Root meristem activity is the most critical process influencing root development. Although several regulatory factors that regulate meristem activity have been identified in rice, studies on the enhancement of meristem activity in roots are limited. We identified a T-DNA activation tagging line of a zinc-finger homeobox gene, OsZHD2, which has longer seminal and lateral roots due to increased meristem activity. Read More

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http://dx.doi.org/10.1093/jxb/eraa209DOI Listing

Sustained remission of Lynch syndrome-associated metastatic adrenocortical carcinoma following checkpoint inhibitor therapy-associated multiorgan autoimmunity.

Clin Endocrinol (Oxf) 2020 May 25. Epub 2020 May 25.

Department of Endocrinology, Austin Health, Heidelberg, Australia.

Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatment options for metastatic disease . Immunotherapy with checkpoint inhibition, in particular anti-programmed death receptor 1 (PD-1)/programmed death-ligand-1 (PD-L1) blockade has transformed the management of several malignancies. We describe prolonged remission of an ectopic-ACTH secreting refractory stage-IV ACC treated with anti-PD-1 antibody nivolumab combined with anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibody ipilimumab. Read More

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http://dx.doi.org/10.1111/cen.14258DOI Listing

Expression of SOAT1 in adrenocortical carcinoma and response to mitotane monotherapy: an ENSAT multicenter study.

J Clin Endocrinol Metab 2020 May 25. Epub 2020 May 25.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.

Context: Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20% and adverse drug effects are frequent. To date there is no marker established that predicts treatment response. Mitotane has been shown to inhibit sterol-O-acyl transferase 1 (SOAT1) which leads to endoplasmic reticulum stress and cell death in ACC cells. Read More

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http://dx.doi.org/10.1210/clinem/dgaa293DOI Listing

Farnesol attenuates oxidative stress and liver injury and modulates fatty acid synthase and acetyl-CoA carboxylase in high cholesterol-fed rats.

Environ Sci Pollut Res Int 2020 May 24. Epub 2020 May 24.

Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni Suef, Egypt.

Dyslipidemia is a risk factor for cardiovascular disease, steatohepatitis, and progression of liver disorders. This study investigated the protective effect of farnesol (FAR), a sesquiterpene alcohol, against liver injury in high cholesterol diet (HCD)-fed rats, and its modulatory effect on fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC). HCD was supplemented for 10 weeks, and the rats were concurrently treated with FAR. Read More

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http://dx.doi.org/10.1007/s11356-020-09296-wDOI Listing

Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated with ketoenol resistance in Bemisia tabaci.

Pestic Biochem Physiol 2020 Jun 13;166:104583. Epub 2020 Apr 13.

Bayer AG, Crop Science Division, R&D, Pest Control, 40789 Monheim, Germany. Electronic address:

Insecticides of the tetronic/tetramic acid family (cyclic ketoenols) are widely used to control sucking pests such as whiteflies, aphids and mites. They act as inhibitors of acetyl-CoA carboxylase (ACC), a key enzyme for lipid biosynthesis across taxa. While it is well documented that plant ACCs targeted by herbicides have developed resistance associated with mutations at the carboxyltransferase (CT) domain, resistance to ketoenols in invertebrate pests has been previously associated either with metabolic resistance or with non-validated candidate mutations in different ACC domains. Read More

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http://dx.doi.org/10.1016/j.pestbp.2020.104583DOI Listing
June 2020
2.014 Impact Factor

Efficacy of adjuvant radiotherapy for treatment of adrenocortical carcinoma: a retrospective study and an updated meta-analysis.

Radiat Oncol 2020 May 24;15(1):118. Epub 2020 May 24.

Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academe of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Background: Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Surgical resection is the standard treatment for localized ACC, but the local recurrence remains high. Adjuvant radiation (ART) has been proposed as a means to reduce recurrence rates in ACC after surgery with conflicting results from nonrandomized studies. Read More

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http://dx.doi.org/10.1186/s13014-020-01533-3DOI Listing

Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study.

J Psychopharmacol 2020 May 25:269881120922977. Epub 2020 May 25.

Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, the Netherlands.

Aims: 22q11.2 deletion syndrome (22q11.2DS) is associated with impaired cognitive functioning. Read More

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http://dx.doi.org/10.1177/0269881120922977DOI Listing

Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella).

Fish Physiol Biochem 2020 May 24. Epub 2020 May 24.

College of Fisheries, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007, People's Republic of China.

Hepatic lipid metabolism disorder due to excessive fat accumulation in fish is a significant problem in aquaculture. Studies have shown that grape seed procyanidin extract (GSPE) can regulate fish lipid metabolism and improve fish immunity. However, the mechanism is unclear. Read More

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http://dx.doi.org/10.1007/s10695-020-00819-3DOI Listing

Shorter sleep duration is associated with lower GABA levels in the anterior cingulate cortex.

Sleep Med 2020 Feb 28;71:1-7. Epub 2020 Feb 28.

Ewha Brain Institute, Ewha W. University, Seoul, South Korea; Department of Brain and Cognitive Sciences, Ewha W. University, Seoul, South Korea. Electronic address:

Background: Alterations in the levels of gamma-aminobutyric acid (GABA) and glutamate + glutamine (Glx), which are major inhibitory and excitatory neurotransmitters, respectively, are frequently associated with insomnia. Previous reports also suggested the involvement of the anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) in insomnia and shorter sleep duration. In the current study, we investigated whether the GABA and Glx levels were altered in the ACC/mPFC in subclinical insomnia while focusing on the sleep duration. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.02.018DOI Listing
February 2020

A bayesian approach to examining default mode network functional connectivity and cognitive performance in major depressive disorder.

Psychiatry Res Neuroimaging 2020 May 17;301:111102. Epub 2020 May 17.

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. Electronic address:

To reconcile the inconsistency of the association between the resting-state functional connectivity (RSFC) and cognitive performance in healthy and depressed groups due to high variance of both measures, we proposed a Bayesian spatio-temporal model to precisely and accurately estimate the RSFC in depressed and nondepressed participants. This model was employed to estimate spatially-adjusted functional connectivity (saFC) in the extended default mode network (DMN) that was hypothesized to correlate with cognitive performance in both depressed and nondepressed. Multiple linear regression models were used to study the relationship between DMN saFC and cognitive performance scores measured in the following four cognitive domains while adjusting for age, sex, and education. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2020.111102DOI Listing

Effects of buffer salts on the freeze-drying survival rate of Lactobacillus plantarum LIP-1 based on transcriptome and proteome analyses.

Food Chem 2020 Apr 30;326:126849. Epub 2020 Apr 30.

Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of PR China, Key Laboratory of Dairy Products Processing, Ministry of Agriculture, PR China; Department of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR China. Electronic address:

Buffer salts are often added to culture medium to promote bacterial growth. However, we found that buffer salts can improve the freeze-drying survival rate. In this experiment, the mechanisms for the effects of different buffer salts on the survival rate of freeze-dried strains were examined. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.126849DOI Listing

ACC-AHA Diagnostic Criteria for Hypertension in Pregnancy Identifies Patients at Intermediate Risk of Adverse Outcomes.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective:  The aim of the study is to compare maternal and neonatal outcomes among patients who are normotensive, hypertensive by Stage I American College of Cardiology-American Heart Association (ACC-AHA) criteria, and hypertensive by American College of Obstetricians and Gynecologists (ACOG) criteria.

Study Design:  Secondary analysis of a prospective first trimester cohort study between 2007 and 2010 at three institutions in Baltimore, MD, was conducted. Blood pressure at 11 to 14 weeks' gestation was classified as (1) normotensive (systolic blood pressure [SBP] <130 mm Hg and diastolic blood pressure [DBP] <80 mm Hg); (2) hypertensive by Stage I ACC-AHA criteria (SBP 130-139 mm Hg or DBP 80-89 mm Hg); or (3) hypertensive by ACOG criteria (SBP ≥140 mm Hg or DBP ≥90 mm Hg). Read More

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http://dx.doi.org/10.1055/s-0040-1709465DOI Listing

Spatio-temporal deep learning methods for motion estimation using 4D OCT image data.

Int J Comput Assist Radiol Surg 2020 May 22. Epub 2020 May 22.

Institute of Medical Technology, Hamburg University of Technology, Hamburg, Germany.

Purpose: Localizing structures and estimating the motion of a specific target region are common problems for navigation during surgical interventions. Optical coherence tomography (OCT) is an imaging modality with a high spatial and temporal resolution that has been used for intraoperative imaging and also for motion estimation, for example, in the context of ophthalmic surgery or cochleostomy. Recently, motion estimation between a template and a moving OCT image has been studied with deep learning methods to overcome the shortcomings of conventional, feature-based methods. Read More

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http://dx.doi.org/10.1007/s11548-020-02178-zDOI Listing

Coronavirus Disease 2019 (COVID-19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease.

J Am Heart Assoc 2020 May 22:e017224. Epub 2020 May 22.

Chair elect of the ACC Adult Congenital and Pediatric Cardiology Section; Congenital Heart Center University of Florida Gainesville FL.

The corona virus disease -2019 (COVID-19) is a recently described infectious disease caused by the severe acute respiratory syndrome corona virus 2 with significant cardiovascular implications. Given the increased risk for severe COVID-19 observed in adults with underlying cardiac involvement, there is concern that patients with pediatric and congenital heart disease (CHD) may likewise be at increased risk for severe infection. The cardiac manifestations of COVID-19 include myocarditis, arrhythmia and myocardial infarction. Read More

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http://dx.doi.org/10.1161/JAHA.120.017224DOI Listing

Dissolution and Precipitation Dynamics at Environmental Mineral Interfaces Imaged by In Situ Atomic Force Microscopy.

Acc Chem Res 2020 May 22. Epub 2020 May 22.

Institut für Mineralogie, University of Münster, 48149 Münster, Germany.

ConspectusChemical reactions at the mineral-solution interface control important interfacial processes, such as geochemical element cycling, nutrient recovery from eutrophicated waters, sequestration of toxic contaminants, and geological carbon storage by mineral carbonation. By time-resolved in situ imaging of nanoscale mineral interfacial reactions, it is possible to clarify the mechanisms governing mineral-fluid reactions.In this Account, we present a concise summary of this topic that addresses a current challenge at the frontier of understanding mineral interfaces and their importance to a wide range of mineral re-equilibration processes in the presence of a fluid aqueous phase. Read More

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http://dx.doi.org/10.1021/acs.accounts.0c00128DOI Listing

Intramolecularly Cross-Linked Polymers: From Structure to Function with Applications as Artificial Antibodies and Artificial Enzymes.

Acc Chem Res 2020 May 22. Epub 2020 May 22.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

ConspectusCross-linking of polymers significantly alters their physical properties, greatly expanding their everyday utility. Indeed, the polymeric networks resulting from linkages between polymer chains are found in everyday materials from soft contact lenses and automobile tires to enamel coatings and high-performance adhesives. In contrast, intramolecularly cross-linked polymers have received far less attention until recent years, in large part because they are synthetically more challenging to prepare. Read More

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http://dx.doi.org/10.1021/acs.accounts.0c00178DOI Listing

Plant Growth-Promoting Traits of a Thermophilic Strain of the Klebsiella Group with its Effect on Rice Plant Growth.

Curr Microbiol 2020 May 21. Epub 2020 May 21.

Department of Microbiology, The University of Burdwan, Burdwan, West Bengal, 713104, India.

In agriculture, instead of synthetic fertilizers, natural bio-inoculants can be used to increase growth and yield of crops. For this purpose, we report a thermophilic bacteria Klebsiella sp. strain PMnew, isolated from Paniphala hot spring. Read More

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http://dx.doi.org/10.1007/s00284-020-02032-0DOI Listing

Functional and Structural Changes in Postherpetic Neuralgia Brain Before and Six Months After Pain Relieving.

J Pain Res 2020 4;13:909-918. Epub 2020 May 4.

Department of Anesthesiology, Zunyi Medical University, Zunyi 563002, Guizhou, People's Republic of China.

Objective: Multimodal magnetic resonance imaging (MRI) was used to detect whether 6 months after pain relieving, the structural and functional abnormalities in the brain of postherpetic neuralgia (PHN) patients are changeable.

Methods: Fifteen successfully treated PHN patients were enrolled; the brain activity and structural abnormalities were detected and compared before and 6 months after treatment. The functional parameters were evaluated with resting-state functional MRI technique, i. Read More

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http://dx.doi.org/10.2147/JPR.S246745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210030PMC

In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study.

Mol Psychiatry 2020 May 21. Epub 2020 May 21.

Department of Biofunctional Imaging, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Alterations in the cortical dopamine system and microglial activation have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), one of neurodevelopmental disorders that can be conventionally treated with a dopamine enhancer (methylphenidate) albeit unsatisfactorily. Here, we investigated the contributions of the dopamine D1 receptor (D1R) and activated microglia and their interactions to the clinical severities in ADHD individuals using positron emission tomography (PET). Twenty-four psychotropic-naïve ADHD individuals and 24 age- and sex-matched typically developing (TD) subjects underwent PET measurements with [C]SCH23390 for the D1R and [C](R)PK11195 for activated microglia as well as assessments of clinical symptoms and cognitive functions. Read More

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http://dx.doi.org/10.1038/s41380-020-0784-7DOI Listing

Distinct region- and time-dependent functional cortical adaptations in C57BL/6J mice after short and prolonged alcohol drinking.

eNeuro 2020 May 21. Epub 2020 May 21.

Department of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, 30 Courtenay Drive, Charleston, SC, 29425

Alcohol (ethanol) use disorder is associated with changes in frontal cortical areas including the anterior cingulate (ACC) and orbitofrontal cortex that contribute to cognitive deficits, uncontrolled drinking, and relapse. Acute ethanol exposure reduces intrinsic excitability of lateral orbitofrontal cortex (lOFC) neurons, while chronic exposure and long-term drinking influence plasticity of intrinsic excitability and function of glutamatergic synapses. However, the time course that these adaptations occur across a history of ethanol drinking is unknown. Read More

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http://dx.doi.org/10.1523/ENEURO.0077-20.2020DOI Listing

Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase.

Steroids 2020 May 18;160:108656. Epub 2020 May 18.

Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, P.O. Box 11231, Nasr City, Cairo, Egypt.

Hydroxycitric acid (HCA), a dietary-derived weight loss supplement, competitively inhibits ATP citrate lyase (ACLY). Tamoxifen (TAM) is the most frequently used therapy for estrogen receptor (ER)-positive breast cancer patients, but its application was restricted due to efficacy related issues. Lipid metabolic reprogramming plays a key role in cancer progression and response to treatment. Read More

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http://dx.doi.org/10.1016/j.steroids.2020.108656DOI Listing

Performance of endoscopic repair with endonasal flaps for congenital choanal atresia. A systematic review.

Acta Otorrinolaringol Esp 2020 May 18. Epub 2020 May 18.

Otolaryngology Department, Barcelona Children's Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Catalonia, Spain.

Endoscopic repair of congenital choanal atresia is the gold standard surgical treatment today. Though several controversies on treatment have been reported, surgical techniques for better outcomes are still in discussion. The objective of this study is to evaluate the performance of endoscopic choanal atresia repair with endonasal flaps and no stents. Read More

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http://dx.doi.org/10.1016/j.otorri.2020.01.002DOI Listing

Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review.

J Am Coll Cardiol 2020 May;75(20):2602-2618

Rush Medical College, Rush University, Chicago, Illinois.

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for women in the United States and worldwide. There has been no American College of Cardiology (ACC)/American Heart Association guideline update specifically for the prevention of CVD in women since 2011. Since then, the body of sex-specific data has grown, in addition to updated hypertension, cholesterol, diabetes, atrial fibrillation, and primary prevention guidelines. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.03.060DOI Listing

Self-Healing Properties of Bioinspired Amorphous CaCO/Polyphosphate-Supplemented Cement.

Molecules 2020 May 19;25(10). Epub 2020 May 19.

ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.

There is a strong interest in cement additives that are able to prevent or mitigate the adverse effects of cracks in concrete that cause corrosion of the reinforcement. Inorganic polyphosphate (polyP), a natural polymer that is synthesized by bacteria, even those on cement/concrete, can increase the resistance of concrete to progressive damage from micro-cracking. Here we use a novel bioinspired strategy based on polyP-stabilized amorphous calcium carbonate (ACC) to give this material self-healing properties. Read More

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http://dx.doi.org/10.3390/molecules25102360DOI Listing

A balanced opinion? Considering the role of the external clinical advisor in ACC processes.

N Z Med J 2020 May 22;133(1515):97-103. Epub 2020 May 22.

Professor, Faculty of Law, University of Auckland, Auckland.

The role of the external clinical advisor is critical to the adjudication of complex claims in the processes of the Accident Compensation Corporation (ACC). This is particularly true of claims for treatment injury that occur during birth, which are often very complicated. In most cases external clinical advisors are non-treating doctors, whose opinion strongly guides the hand of ACC. Read More

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Characteristics of adrenocortical carcinoma in South Korea: a registry-based nationwide survey.

Endocr Connect 2020 May 1. Epub 2020 May 1.

J Kim, Internal Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul, 135-710, Korea (the Republic of).

Purpose: To evaluate the clinical characteristics and prognostic factors in patients with adrenocortical carcinoma (ACC) in South Korea.

Methods: A nationwide, registry-based survey was conducted to identify pathologically proven ACC at 25 tertiary care centers in South Korea between 2000 and 2014. Cox proportional hazard model and log-rank test were adopted for survival analysis. Read More

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http://dx.doi.org/10.1530/EC-20-0196DOI Listing

Reduced striatal GABA in unmedicated children with ADHD at 7T.

Psychiatry Res Neuroimaging 2020 May 18;301:111082. Epub 2020 May 18.

Department of Neuropsychology, Kennedy Krieger Institute, 1750 E. Fairmount Ave., Baltimore, MD 21231 United States; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 N Wolfe St., Baltimore, MD 21287, United States.

Attention-deficit hyperactive disorder (ADHD) is characterized by inattention and increased impulsive and hypermotoric behaviors.Despite the high prevalence and impact of ADHD, little is known about the underlying neurophysiology of ADHD. The main inhibitory and excitatory neurotransmitters γ-aminobutyric acid (GABA) and glutamate are receiving increased attention in ADHD and can be measured using Magnetic Resonance Spectroscopy (MRS). Read More

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http://dx.doi.org/10.1016/j.pscychresns.2020.111082DOI Listing

Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation.

Biochem Pharmacol 2020 May 8;177:114022. Epub 2020 May 8.

Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. Electronic address:

Increased cholesterol efflux from macrophage foam cells in the subendothelial space confers protection against atherosclerosis. Soraphen A, a myxobacterial macrolactone, is an inhibitor of acetyl coenzyme A carboxylases (ACC), which control fatty acid synthesis and oxidation. To assess a potential direct link between macrophage cholesterol efflux and ACC inhibition, we examined [H]-cholesterol efflux from human THP-1-derived foam cells in the presence of soraphen A. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114022DOI Listing

Chemical Imaging of Surfaces with Sum Frequency Generation Vibrational Spectroscopy.

Acc Chem Res 2020 May 21. Epub 2020 May 21.

Department of Chemistry, University of Houston, Houston, Texas 77204, United States.

ConspectusSurface chemistry is a key area of study in the chemical sciences, and many system properties are dominated by the chemistry at the interface between two bulk media. While the interface may have a large influence on the system behavior, there are relatively few molecules at the interface compared to the bulk; thus, probing their unique properties has become a specialized field in physical chemistry. In addition to the heterogeneous phase chemistry, surfaces also present spatial heterogeneity (Chemistry in Two Dimensions). Read More

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http://dx.doi.org/10.1021/acs.accounts.0c00057DOI Listing

"Imaging of multiple plant hormones in roots of rice (Oryza sativa) using nanoparticle assisted laser desorption/ionization mass spectrometry.

J Agric Food Chem 2020 May 21. Epub 2020 May 21.

Plant hormones can act in synergistic and antagonistic ways in response to biotic and abiotic stresses as well as in plant growth and development. Thus, a technique is needed to simultaneously determine the distributions and concentrations of several plant hormones. Previously, we reported that localizations of two plant hormeses [cytokinin (CK) and abscisic acid (ABA)] can be simultaneously visualized in a plant tissue using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS). Read More

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http://dx.doi.org/10.1021/acs.jafc.0c00749DOI Listing

Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.

J Psychiatry Neurosci 2020 May 20;45(4):190015. Epub 2020 May 20.

From the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).

Background: Dysfunction of the corticostriatal network has been implicated in the pathophysiology of schizophrenia, but findings are inconsistent within and across imaging modalities. We used multimodal neuroimaging to analyze functional and structural connectivity in the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.

Methods: We collected resting-state functional magnetic resonance imaging and diffusion tensor imaging scans from people with schizophrenia (n = 47), relatives (n = 30) and controls (n = 49). Read More

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http://dx.doi.org/10.1503/jpn.190015DOI Listing

Extracts of Moringa oleifera leaves from different cultivation regions show both antioxidant and antiobesity activities.

J Food Biochem 2020 May 20:e13282. Epub 2020 May 20.

Department of Chemical Engineering, Graduate School of Chosun University, Gwangju, Republic of Korea.

Moringa oleifera is rich in nutrients, such as protein, vitamins, and phytochemicals, and has been used as a traditional remedy. In this study, extracts of M. oleifera leaves from South Korea and Cambodia were evaluated for their antioxidant and antiobesity activities and for food and natural medicine use. Read More

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http://dx.doi.org/10.1111/jfbc.13282DOI Listing
May 2020
0.741 Impact Factor

Evaluation of Cardiovascular Risk in Patient with Primary Non-alcoholic Fatty Liver Disease.

High Blood Press Cardiovasc Prev 2020 May 20. Epub 2020 May 20.

Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, c/o 2a Medicina Spedali Civili di Brescia, Piazza Spedali Civili 1, 25100, Brescia, Italy.

Introduction: The study aimed to investigate, in patients with primary non-alcoholic fatty liver disease (NAFLD), the presence of possible relationships between the degree of steatosis or fibrosis and the individual cardiovascular risk and possibly whether a difference between those various methods exists.

Methods: Thirty-four adult patients with primary NAFLD were included in this study. Clinical evaluation included an ultrasonographic examination for the determination of the severity of steatosis. Read More

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http://dx.doi.org/10.1007/s40292-020-00389-8DOI Listing

Severity of heart failure and health-related quality of life in beta-thalassemia patients: a cross-sectional study.

Ann Hematol 2020 May 21. Epub 2020 May 21.

First Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Cardiovascular complications account for a substantial increase in morbidity and mortality in beta-thalassemia patients. Many patients have structural heart disease, and some of them present with symptomatic heart failure (HF). Quality of life (QOL) of beta-thalassemia patients is lower than that of the general population. Read More

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http://dx.doi.org/10.1007/s00277-020-04032-3DOI Listing

Medium-, long- and medium-chain-type structured lipids ameliorate high-fat diet-induced atherosclerosis by regulating inflammation, adipogenesis, and gut microbiota in ApoE mice.

Food Funct 2020 May 20. Epub 2020 May 20.

College of Food Science, Northeast Agricultural University, Changjiang Road, Harbin 150036, China.

Accumulating evidence has suggested that medium-, long-, and medium-chain (MLM) structured lipids have anti-obesity effects, but whether they can alleviate the development of atherosclerosis (AS) and affect the composition of the gut microbiota in high-fat diet-fed ApoE-/- mice has not been elucidated. The present study found that MLM structured lipid supplementation could significantly decrease obesity-related parameters compared with high-fat diet alone in ApoE-/- mice. Additionally, MLM structured lipids could significantly decrease the blood glucose and increase the serum total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) levels. Read More

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http://dx.doi.org/10.1039/d0fo01006eDOI Listing

Liquid-Liquid Phase Separation in Supermicrometer and Submicrometer Aerosol Particles.

Acc Chem Res 2020 May 20. Epub 2020 May 20.

Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

ConspectusThe interactions of aerosol particles with light and clouds are among the most uncertain aspects of anthropogenic climate forcings. The effects of aerosol particles on climate depend on their optical properties, heterogeneous chemistry, water uptake behavior, and ice nucleation activity. These properties in turn depend on aerosol physics and chemistry including composition, size, shape, internal structure (morphology), and phase state. Read More

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http://dx.doi.org/10.1021/acs.accounts.0c00093DOI Listing

Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial.

Hum Reprod 2020 May 20. Epub 2020 May 20.

Department of Biostatistics, Yale University School of Public Health, New Haven, CT 06520, USA.

Study Question: Are intrauterine insemination (IUI) performance characteristics and post-processing total motile sperm count (TMC) related to live birth rate in couples with unexplained infertility?

Summary Answer: Patient discomfort with IUI and lower inseminate TMC were associated with a reduced live birth rate, while time from hCG injection to IUI, sperm preparation method and ultrasound guidance for IUI were not associated with live birth success.

What Is Already Known: We previously determined that some baseline characteristics of couples with unexplained infertility, including female age, duration of infertility, history of prior loss and income, were related to live birth rate across a course of ovarian stimulation and IUI treatment. However, the relationship between treatment outcomes and per-cycle characteristics, including ultrasound guidance for IUI, timing of IUI relative to hCG injection, difficult or painful IUI and inseminate TMC, are controversial, and most prior investigations have not evaluated live birth outcome. Read More

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http://dx.doi.org/10.1093/humrep/deaa027DOI Listing

Komagataeibacter hansenii CGMCC 3917 alleviates alcohol-induced liver injury by regulating fatty acid metabolism and intestinal microbiota diversity in mice.

Food Funct 2020 May 20;11(5):4591-4604. Epub 2020 May 20.

Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.

The potential effects of Komagataeibacter hansenii CGMCC 3917 cells on alcohol-induced liver injury and their probable mechanisms were investigated. Male Kunming mice were orally administered with alcohol (10 mL per kg BW) alone or in combination with administration of K. hansenii CGMCC 3917 cells at 2 × 10 and 2 × 10 CFUs for 10 weeks. Read More

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http://dx.doi.org/10.1039/c9fo02040cDOI Listing

A Method for Prediction of Thermophilic Protein Based on Reduced Amino Acids and Mixed Features.

Front Bioeng Biotechnol 2020 5;8:285. Epub 2020 May 5.

Information and Computer Engineering College, Northeast Forestry University, Harbin, China.

The thermostability of proteins is a key factor considered during enzyme engineering, and finding a method that can identify thermophilic and non-thermophilic proteins will be helpful for enzyme design. In this study, we established a novel method combining mixed features and machine learning to achieve this recognition task. In this method, an amino acid reduction scheme was adopted to recode the amino acid sequence. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214540PMC

DTI-based radiomics signature for the detection of early diabetic kidney damage.

Abdom Radiol (NY) 2020 May 19. Epub 2020 May 19.

The First Affiliated Hospital, Jinan University, Guangzhou, 510630, People's Republic of China.

Objective: To explore whether a radiomics signature based on diffusion tensor imaging (DTI) can detect early kidney damage in diabetic patients.

Materials And Methods: Twenty-eight healthy volunteers (group A) and thirty type 2 diabetic patients (group B) with micro-normoalbuminuria, a urinary albumin-to-creatinine ratio (ACR) < 30 mg/g and an estimated glomerular filtration rate (eGFR) of 60-120 mL/(min 1.73 m) were recruited. Read More

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http://dx.doi.org/10.1007/s00261-020-02576-6DOI Listing