21,054 results match your criteria ACC Cardiosource Review Journal CRJ[Journal]


The new US and European guidelines in hypertension: A multi-dimensional analysis.

Contemp Clin Trials 2019 Apr 16. Epub 2019 Apr 16.

Medbase, Chapel Hill, NC, USA.

The Systolic Blood Pressure Intervention Trial (SPRINT) compared the clinical outcomes between target systolic blood pressure (SBP) levels between 140 and 120 mmHg or lower. Both,the 2017 ACC/AHA and the 2018 ESC/ESH guidelines in hypertension are derived from the SPRINT trial and advise initiation and/or intensification of treatment at lower blood pressure thresholds. The ACC/AHA guidance supersedes the 2014 Eight Joint National Committee guideline (JNC-8) which advised initiation of treatment when the BP was 140/90 mmHg or higher; in adults 60 years or over, the target was 150/90 mmHg. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15517144183071
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http://dx.doi.org/10.1016/j.cct.2019.04.008DOI Listing
April 2019
1 Read

Effect of estradiol on hepatopancreatic lipid metabolism in the swimming crab, Portunus trituberculatus.

Gen Comp Endocrinol 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition of Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai, 201306, China; National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China. Electronic address:

Estradiol is an important sex steroid hormone that involved in regulation of animal lipid metabolism. However, the effect of estradiol on lipid metabolism in swimming crab (Portunus trituberculatus) is unclear. The present study investigated the effect of four concentrations of exogenous estradiol (0, 0. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.019DOI Listing

Improving Homogeneous Cationic Gold Catalysis through a Mechanism-Based Approach.

Acc Chem Res 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai 201620 , China.

Homogeneous gold catalysis is regarded as a landmark addition to the field of organic synthesis. It is the most effective way to activate alkynes for the addition of a diverse host of nucleophiles. However, the literature reveals that a relatively high catalyst loading is needed in many gold-catalyzed applications (1-10 mol %), which is impractical in large-scale synthesis or multistep synthesis because of the high price and recyclization difficulty of the gold. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00544DOI Listing

A Comparison of Intradermal Skin Testing and Serum Insect Allergen-specific IgE Determination in Horses With Insect Bite Hypersensitivity From 2008 to 2016.

J Equine Vet Sci 2019 Apr 1;75:65-68. Epub 2019 Feb 1.

Department of Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.

New techniques in equine veterinary allergy testing include multiple allergen simultaneous tests (MASTs) that cover insect bite hypersensitivity (IBH), respiratory and atopic allergic diseases. The in vivo intradermal test (IDT) method is one of the most widely used techniques in veterinary practice, but recently, in vitro methods have been introduced as possible alternatives. This study was designed to assess the correlation between IDTs and MASTs based on IgE determination in serum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07370806183073
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http://dx.doi.org/10.1016/j.jevs.2019.01.007DOI Listing
April 2019
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Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review.

Cancer Biol Ther 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Department of Pathology , Radboud Institute for Molecular Life Sciences, Radboud university medical center , Nijmegen , The Netherlands.

Acinar cell carcinoma (ACC) is a rare pancreatic neoplasm with dismal prognosis. Insights into the molecular basis of ACC can pave the way for the application of more effective, personalized therapies and detection of patients with hereditary predisposition. Molecular analysis revealed a germline BRCA2 (and CHEK2) mutation in a patient with a rare pancreatic ACC with extensive intraductal growth. Read More

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https://www.tandfonline.com/doi/full/10.1080/15384047.2019.1
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http://dx.doi.org/10.1080/15384047.2019.1595274DOI Listing
April 2019
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Aberrant Brain Function in Active-Stage Ulcerative Colitis Patients: A Resting-State Functional MRI Study.

Front Hum Neurosci 2019 3;13:107. Epub 2019 Apr 3.

Department of Radiology, XinQiao Hosptial, Third Military Medical University, ChongQing, China.

: Patients with ulcerative colitis (UC) usually display cognitive impairments, such as memory loss, attention deficits, and declining executive functions, particularly during the active stage of the disease. However, the potential neurological mechanisms of these symptoms remain unclear. : Forty-one patients with mildly to moderately active UC, as well as 42 matched healthy controls, were recruited for an examination using psychological scales, cognitive function tests and resting-state functional magnetic resonance imaging (rs-fMRI). Read More

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http://dx.doi.org/10.3389/fnhum.2019.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457314PMC

Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.

Sci Rep 2019 Apr 18;9(1):6266. Epub 2019 Apr 18.

Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae remain a critical clinical concern worldwide. The aim of this study was to characterize ESBL-producing K. pneumoniae detected within and between two hospitals in uMgungundlovu district, South Africa, using whole genome sequencing (WGS). Read More

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http://dx.doi.org/10.1038/s41598-019-42672-2DOI Listing

The Admission Conference Call: A Novel Approach to Optimizing Pediatric Emergency Department to Admitting Floor Communication.

Jt Comm J Qual Patient Saf 2019 Apr 15. Epub 2019 Apr 15.

Optimizing information sharing at transfer of care between teams is an important target for the improvement of patient safety. Traditional emergency department (ED)-to-floor handoffs do not support a shared mental model between physicians, residents, and nurses. This report describes and evaluates acceptance of a novel process for coordinating physician and nursing handoff calls for patients being admitted to an inpatient floor from a children's hospital ED. Read More

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http://dx.doi.org/10.1016/j.jcjq.2019.02.008DOI Listing

Ambulatory blood pressure monitoring in clinical practice.

Indian Heart J 2019 Jan - Feb;71(1):91-97. Epub 2018 Nov 27.

Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address:

Being one of the most widely prevalent diseases throughout the world, hypertension has emerged as one of the leading causes of global premature morbidity and mortality. Hence, blood pressure (BP) measurements are essential for physicians in the diagnosis and management of hypertension. Current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend initiating antihypertensive medications on the basis of office BP readings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00194832183057
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http://dx.doi.org/10.1016/j.ihj.2018.11.015DOI Listing
November 2018
1 Read

Uncovering the Real Power and Value Behind ACC Membership.

Authors:
Richard J Kovacs

J Am Coll Cardiol 2019 Apr;73(15):1999-2000

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http://dx.doi.org/10.1016/j.jacc.2019.03.460DOI Listing

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.

Emerg Microbes Infect 2019 ;8(1):624-636

a Department of Biotechnology , Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) , Madrid , Spain.

Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection. Considering the central role of acetyl-Coenzyme A carboxylase (ACC) on fatty acid metabolism, we analyzed the effect of three small-molecule ACC inhibitors (PF-05175157, PF-05206574, and PF-06256254) on the infection of medically relevant flaviviruses, namely West Nile virus (WNV), dengue virus, and Zika virus. Read More

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https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1
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http://dx.doi.org/10.1080/22221751.2019.1604084DOI Listing
January 2019
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An In Silico Model for Predicting Drug-Induced Hepatotoxicity.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.

As one of the leading causes of drug failure in clinical trials, drug-induced liver injury (DILI) seriously impeded the development of new drugs. Assessing the DILI risk of drug candidates in advance has been considered as an effective strategy to decrease the rate of attrition in drug discovery. Recently, there have been continuous attempts in the prediction of DILI. Read More

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http://dx.doi.org/10.3390/ijms20081897DOI Listing

Genetic evaluation of bovine papillomavirus types detected in equine sarcoids in Poland.

Pol J Vet Sci 2019 Mar;22(1):25-29

Department of Epizootiology, Faculty of Veterinary Medicine,University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland.

Background: Equine sarcoids are the most common neoplasms in horses. Bovine papilloma- virus type 1 (BPV-1) is the main viral type identified in equine sarcoids in Europe.

Objective: The aim of the present study was to genetically evaluate BPV types based on DNA analyses of the CDS of the L1 gene. Read More

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http://journals.pan.pl/dlibra/publication/125602
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http://dx.doi.org/10.24425/pjvs.2018.125602DOI Listing
March 2019
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The endocytic pathways of carbon dots in human adenoid cystic carcinoma cells.

Cell Prolif 2019 Apr 17:e12586. Epub 2019 Apr 17.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Objectives: This study aimed at investigating cellular uptake pathways of carbon dots (CDs) in human adenoid cystic carcinoma cell line ACC-2.

Materials And Methods: We synthesized CDs using a hydrothermal method with citric acid and polyethylenimine (PEI, Mw = 25 000). The CDs incubated with the ACC-2 cells showed their bioimaging capabilities using a confocal microscopy test. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.12586
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http://dx.doi.org/10.1111/cpr.12586DOI Listing
April 2019
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[Comprehensive treatment of adrenal cortical carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

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April 2019
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l-carnitine and fat type in the maternal diet during gestation and lactation modify the fatty acid composition and expression of lipid metabolism-related genes in piglets.

J Anim Physiol Anim Nutr (Berl) 2019 Apr 17. Epub 2019 Apr 17.

Institute of Animal Nutrition, Northeast Agricultural University, Harbin, China.

This study examined the influence of adding different amounts of maternal dietary l-carnitine and two fat types on fatty acid (FA) composition and the expression of lipid metabolism-related genes in piglets. The experiment was designed as a 2 × 2 factorial with two fat types (3.5% soyabean oil, SO, and 3. Read More

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http://dx.doi.org/10.1111/jpn.13099DOI Listing

Nonviral Gene Delivery with Cationic Glycopolymers.

Acc Chem Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry , University of Minnesota , 207 Pleasant Street SE , Minneapolis , Minnesota 55455 , United States.

The field of gene therapy, which aims to treat patients by modulating gene expression, has come to fruition and has landed several landmark FDA approvals. Most gene therapies currently rely on viral vectors to deliver nucleic acid cargo into cells, but there is significant interest in moving toward chemical-based methods, such as polymer-based vectors, due to their low cost, immunocompatibility, and tunability. The full potential of polymer-based delivery systems has yet to be realized, however, because most polymeric transfection reagents are either too inefficient or too toxic for use in the clinic. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00665
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http://dx.doi.org/10.1021/acs.accounts.8b00665DOI Listing
April 2019
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Contextual knowledge provided by a movie biases implicit perception of the protagonist.

Soc Cogn Affect Neurosci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neuroscience and Biomedical Engineering, Aalto University, Finland.

We are constantly categorizing other people as belonging to our in-group ("one of us") or out-group ("one of them"). Such grouping occurs fast and automatically and can be based on others' visible characteristics such as skin color or clothing style. Here we studied neural underpinnings of implicit social grouping not often visible on the face, male sexual orientation. Read More

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http://dx.doi.org/10.1093/scan/nsz028DOI Listing

Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway.

Food Funct 2019 Apr 17. Epub 2019 Apr 17.

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China. and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China.

Ginsenoside Rk3 (G-Rk3) is a main active ingredient of ginsenosides. Several recent studies demonstrated that ginsenosides have potential anti-type 2 diabetes mellitus (T2DM) properties. To evaluate the anti-T2DM effect of G-Rk3 and verify its potential mechanism, a high-fat-diet/streptozocin (HFD/STZ) induced model of T2DM in C57BL/6 mice and a high glucose induced insulin resistance model of HepG2 cells were applied in this research. Read More

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http://dx.doi.org/10.1039/c9fo00095jDOI Listing

Guidelines impact cholesterol management.

J Clin Lipidol 2019 Mar 18. Epub 2019 Mar 18.

Division of Cardiology, Baylor Scott & White Health, Temple TX, USA.

Background: Previous research demonstrates increased utilization of high-intensity statins, but unchanged low-density lipoprotein cholesterol (LDL-C) levels, immediately after the 2013 American College of Cardiology (ACC) and the American Heart Association (AHA) guideline release.

Objective: The objective of this study was to determine achievement of statin therapy goals in patients with atherosclerotic cardiovascular disease (ASCVD) before and up to 4 years after the 2013 ACC/AHA guideline release compared with LDL-C goals of <70 mg/dL and <100 mg/dL previously recommended by other professional societies.

Methods: The single-system cohort study used medical records, laboratory results, and claims data (November 2012-October 2017) of adults with ≥1 claim for a statin, ≥1 ASCVD diagnosis in propensity score-matched analyses. Read More

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http://dx.doi.org/10.1016/j.jacl.2019.03.002DOI Listing

Adjuvant mitotane therapy is beneficial in non-metastatic adrenocortical carcinoma at high risk of recurrence.

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

M Terzolo, Department of Clinical and Biological Sciences, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy.

Objective: Many patients with adrenocortical carcinoma (ACC) suffer from tumor recurrence despite radical surgery. Evidence on the post-operative use of mitotane is controversial and no predictors of response are available. We aimed to assess whether adjuvant mitotane treatment may prolong survival in patients with non-metastatic ACC following complete resection and whether ACC patients at high risk of recurrence may benefit from treatment. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0923DOI Listing
April 2019
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Regulation of antioxidant production, ion uptake and productivity in potato (Solanum tuberosum L.) plant inoculated with growth promoting salt tolerant Bacillus strains.

Ecotoxicol Environ Saf 2019 Apr 13;178:33-42. Epub 2019 Apr 13.

Department of Environmental Sciences, COMSATS University Islamabad, Vehari-Campus, Vehari, 61100, Pakistan. Electronic address:

The exchangeable sodium (Na) in salt affected soils is a major constraint in potassium (K) availability to plants that disturb ion transport and inhibit plant growth, adversely. Salt tolerant plant growth promoting rhizobacteria (PGPR) may regulate the Na/K efflux and increase K uptake by the plant from the soil. Therefore, a pot study was performed to examine the effect of salt tolerant PGPR Bacillus sp. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.027DOI Listing

Controlling Nanoparticles with Atomic Precision.

Acc Chem Res 2019 Jan;52(1)

The University of Tokyo.

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http://dx.doi.org/10.1021/acs.accounts.8b00631DOI Listing
January 2019

SIRT6 abrogation promotes adrenocortical carcinoma through activation of NF-κB signaling.

Mol Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Eugenics, Women and Children's Hospital of Sichuan Province, Chengdu, 610043, China.

As an uncommon malignancy in the adrenal gland, adrenocortical carcinoma (ACC) is characterized by thorny diagnosis and poor clinical outcome, necessitating innovative treatment strategies. Sirtuin 6 (SIRT6), a tumor suppressor, modulates aerobic glycolysis of malignant cells and has an impact on tumorigenesis. This study focused on investigating SIRT6 expression in ACC and how it generates cancer phenotypes. Read More

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http://link.springer.com/10.1007/s11010-019-03525-8
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http://dx.doi.org/10.1007/s11010-019-03525-8DOI Listing
April 2019
2 Reads

Toward the Targeted Design of Molecular Ferroelectrics: Modifying Molecular Symmetries and Homochirality.

Acc Chem Res 2019 Apr 15. Epub 2019 Apr 15.

Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics , Southeast University , Nanjing 211189 , People's Republic of China.

Although the first ferroelectric discovered in 1920 is Rochelle salt, a typical molecular ferroelectric, the front-runners that have been extensively studied and widely used in diverse applications, such as memory elements, capacitors, sensors, and actuators, are inorganic ferroelectrics with excellent electrical, mechanical, and optical properties. With the increased concerns about the environment, energy, and cost, molecular ferroelectrics are becoming promising supplements for inorganic ferroelectrics. The unique advantages of high structural tunability and homochirality, which are unavailable in their inorganic counterparts, make molecular systems a good platform for manipulating ferroelectricity. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00677DOI Listing
April 2019
1 Read

Allenation of Terminal Alkynes with Aldehydes and Ketones.

Acc Chem Res 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Recognition and Synthesis, Department of Chemistry , Zhejiang University , Hangzhou , 310027 Zhejiang , People's Republic of China.

So far, over 150 natural products and pharmaceuticals containing an allene moiety have been identified. During the last two decades, allenes have also been demonstrated as synthetically versatile starting materials in organic synthesis. In comparison to alkenes and alkynes, allenes are unique unsaturated hydrocarbons due to their axial chirality, which could be transformed to central chirality via chirality transfer to provide an irreplaceable entry to chiral molecules. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00023DOI Listing
April 2019
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Emotional Mirror Neurons in the Rat's Anterior Cingulate Cortex.

Curr Biol 2019 Mar 28. Epub 2019 Mar 28.

Social Brain Lab, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands; Department of Psychology, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, the Netherlands. Electronic address:

How do the emotions of others affect us? The human anterior cingulate cortex (ACC) responds while experiencing pain in the self and witnessing pain in others, but the underlying cellular mechanisms remain poorly understood. Here we show the rat ACC (area 24) contains neurons responding when a rat experiences pain as triggered by a laser and while witnessing another rat receive footshocks. Most of these neurons do not respond to a fear-conditioned sound (CS). Read More

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http://dx.doi.org/10.1016/j.cub.2019.03.024DOI Listing
March 2019
2 Reads

[Systematic review of the methodology quality and reporting quality in colorectal cancer screening guidelines].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Apr;53(4):398-404

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medial Sciences and Peking Union Medical College, Beijing 100021, China.

To systematically review the quality and reporting quality of colorectal cancer screening guidelines, and to provide reference for the update of colorectal cancer screening guidelines and colorectal cancer screening in China. "Colorectal cancer", "colorectal tumor", "screening", "screening", "guide", "consensus", "Colorectal cancer", "Colorectal neoplasms", "Screening", "Early Detection of Cancer", "Guideline" and "recommendation" were used as search keywords. The literature retrieval for all the Chinese and English guidelines published before April 2018 was conducted by using PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, China Biology Medicine disc (CBMdisc), Cochrane Library, Guideline International Network, China Guidelines Clearinghouse (CGC) and the official website of the US Preventive Services Task Force (USPSTF), the American Cancer Society (ACS), International Agency for Research on Cancer (IARC), Australia Cancer Council (ACC) and Association of Coloproctology of Great Britain & Ireland (ACPGBI). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.04.013DOI Listing

Antidiabetic effect of mangiferin in combination with oral hypoglycemic agents metformin and gliclazide.

Phytomedicine 2019 Mar 22;59:152901. Epub 2019 Mar 22.

Natural Products Research Laboratory, Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605014, India. Electronic address:

Background: Diabetes mellitus poses serious threat to the global population due to the alarming diabetic complications it leads to. The current therapeutic options available can be improved for better efficiency and maximum benefits. Combination therapy has been commonly used to improve the efficacy and to minimize the side effects of drugs in current clinical use. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152901DOI Listing

Characterization of cadmium-resistant rhizobacteria and their promotion effects on Brassica napus growth and cadmium uptake.

J Basic Microbiol 2019 Apr 13. Epub 2019 Apr 13.

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Excessive cadmium (Cd) accumulation in soil can adversely affect plants, animals, microbes, and humans; therefore, novel and uncharacterized Cd-resistant plant-growth-promoting rhizobacteria (PGPR) are required to address this issue. In the paper, 13 bacteria were screened, their partial 16S rRNA sequences determined, and the isolates respectively clustered into Curtobacterium (7), Chryseobacterium (4), Cupriavidus (1), and Sphingomonas (1). Evaluation of PGP traits, including indole-3-acetic acid (IAA) production, 1-aminocyclopropane-1-carboxylate (ACC) deaminase activity, siderophore secretion, and cyanhydric acid production, identified Cupriavidus necator GX_5, Sphingomonas sp. Read More

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http://dx.doi.org/10.1002/jobm.201800656DOI Listing

Beyond amino acid sequence: disulfide bonds and the origins of the extreme amyloidogenic properties of insulin's H-fragment.

FEBS J 2019 Apr 13. Epub 2019 Apr 13.

Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteur Str, 02-093, Warsaw, Poland.

The presence of disulfide bonds affects the protein stability and therefore tendency to misfold and form amyloid-like fibrils. Insulin's three disulfide bridges stabilize the native state and prevent aggregation. Partial proteolysis of insulin releases highly amyloidogenic and inherently disordered two-chain 'H-fragment' retaining insulin's Cys7A-Cys7B and Cys6A-Cys11A disulfide bonds. Read More

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http://dx.doi.org/10.1111/febs.14849DOI Listing

Reproducibility and Repeatability of Five Different Technologies for Bar Velocity Measurement in Resistance Training.

Ann Biomed Eng 2019 Apr 12. Epub 2019 Apr 12.

Human Performance and Sports Science Laboratory, Faculty of Sport Sciences, University of Murcia, C/ Argentina s/n, Santiago de la Ribera, Murcia, Spain.

This study aimed to analyze the agreement between five bar velocity monitoring devices, currently used in resistance training, to determine the most reliable device based on reproducibility (between-device agreement for a given trial) and repeatability (between-trial variation for each device). Seventeen resistance-trained men performed duplicate trials against seven increasing loads (20-30-40-50-60-70-80 kg) while obtaining mean, mean propulsive and peak velocity outcomes in the bench press, full squat and prone bench pull exercises. Measurements were simultaneously registered by two linear velocity transducers (LVT), two linear position transducers (LPT), two optoelectronic camera-based systems (OEC), two smartphone video-based systems (VBS) and one accelerometer (ACC). Read More

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http://dx.doi.org/10.1007/s10439-019-02265-6DOI Listing

Adrenocortical carcinoma: presentation and outcome of a contemporary patient series.

Endocrine 2019 Apr 12. Epub 2019 Apr 12.

Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Adrenocortical carcinoma (ACC) is a rare endocrine carcinoma with poor 5-year survival rates of < 40%. According to the literature, ACC is rarely an incidental imaging finding. However, presentation, treatment and outcome may differ in modern series. Read More

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http://dx.doi.org/10.1007/s12020-019-01918-9DOI Listing

Co-application of ACC-deaminase producing PGPR and timber-waste biochar improves pigments formation, growth and yield of wheat under drought stress.

Sci Rep 2019 Apr 12;9(1):5999. Epub 2019 Apr 12.

Department of Soil Science, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, Multan, 60800, Punjab, Pakistan.

Besides other deleterious effects, drought elevates ethylene level too in plants. Increased ethylene concentration reduces root elongation and development that consequently retard plant growth and yield. There are certain PGPR which produce ACC-deaminase. Read More

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http://dx.doi.org/10.1038/s41598-019-42374-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461675PMC

Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination.

Nat Commun 2019 Apr 12;10(1):1696. Epub 2019 Apr 12.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077, China.

Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg-functional Mg-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg-BP coordination, thus producing (Mg-BP)-Au dimer (MgBNP). Ethylenediaminetetraacetic acid-based Mg chelation facilitates the dissolution of Mg-BP NP, thus enabling the reversion of the MgBNP to the BNP. Read More

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http://www.nature.com/articles/s41467-019-09733-6
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http://dx.doi.org/10.1038/s41467-019-09733-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461616PMC
April 2019
3 Reads

2018 ACC/HRS/NASCI/SCAI/SCCT Expert Consensus Document on Optimal Use of Ionizing Radiation in Cardiovascular Imaging: Best Practices for Safety and Effectiveness-A Review for the Cardiac Anesthesiologist.

J Cardiothorac Vasc Anesth 2019 Jan 8. Epub 2019 Jan 8.

Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Columbia University Medical Center, New York, NY.

The American College of Cardiology, in collaboration with the American Society of Nuclear Cardiology, Heart Rhythm Society, Mended Hearts, North American Society for Cardiovascular Imaging, Society for Cardiovascular Angiography and Interventions, Society for Cardiovascular Computed Tomography, and Society of Nuclear Medicine and Molecular Imaging, recently published a consensus document recommending best practices for the use of ionizing radiation in cardiovascular medicine. With the increase in number and complexity of catheter-based cardiovascular interventions, cardiothoracic anesthesiologists are being requested to consult and provide care for these patients. This review summarizes the salient portions of the consensus document as it pertains to the anesthesiologist. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.006DOI Listing
January 2019

Biodentine Boosts, WhiteProRootMTA Increases and Life Suppresses Odontoblast Activity.

Materials (Basel) 2019 Apr 11;12(7). Epub 2019 Apr 11.

Institute of Integrated Clinical Practice, Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

(1) Background: When pulp exposure occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain the vitality and function of the tissue. The aim of this work was to assess the cytotoxicity and bioactivity of three different direct pulp capping materials, calcium hydroxide (Life), mineral trioxide aggregate (WhiteProRootMTA) and calcium silicate (Biodentine), in an odontoblast-like mouse cell line (MDPC-23). (2) Methods: Metabolic activity was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test (MTT)assay, viability by the sulforhodamine B (SRB) assay, and the type of death and cell cycle analysis by flow cytometry. Read More

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https://www.mdpi.com/1996-1944/12/7/1184
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http://dx.doi.org/10.3390/ma12071184DOI Listing
April 2019
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Apoptosis regulation in adrenocortical carcinoma.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

D Pignatelli, Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Porto, 4099-002, Portugal.

Apoptosis evading is a hallmark of cancer. Tumor cells are characterized by having an impaired apoptosis signaling, a fact that deregulates the balance between cell death and survival, leading to tumor development, invasion and resistance to treatment. In general, patients with adrenocortical carcinomas (ACC) have an extremely bad prognosis, which is related to disease progression and significant resistance to treatments. Read More

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http://dx.doi.org/10.1530/EC-19-0114DOI Listing
April 2019
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Reactivity of [FeS] Clusters toward C1 Substrates: Mechanism, Implications, and Potential Applications.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Molecular Biology and Biochemistry , University of California , Irvine , California 92697-3900 , United States.

FeS proteins are metalloproteins prevalent in the metabolic pathways of most organisms, playing key roles in a wide range of essential cellular processes. A member of this protein family, the Fe protein of nitrogenase, is a homodimer that contains a redox-active [FeS] cluster at the subunit interface and an ATP-binding site within each subunit. During catalysis, the Fe protein serves as the obligate electron donor for its catalytic partner, transferring electrons concomitant with ATP hydrolysis to the cofactor site of the catalytic component to enable substrate reduction. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00063DOI Listing

Blunted Cardiac AMPK Response is Associated with Susceptibility to Ischemia/Reperfusion in Male Offspring of Gestational Diabetic Rats.

Cell Physiol Biochem 2019 ;52(5):1103-1116

International Collaborative Joint Laboratory of Reproduction and Development, Ministry of Education, Chongqing Medical University, Chongqing, China.

Background/aims: Gestational diabetes mellitus (GDM) is closely associated with early perinatal complications and long-term health problems, such as cardiovascular disease, in offspring. AMP-activated protein kinase (AMPK) is cardioprotective, particularly in the treatment of ischemia/reperfusion (I/R). However, whether GDM programs offspring susceptibility to cardiac I/R and the involvement of AMPK remain unclear. Read More

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http://dx.doi.org/10.33594/000000075DOI Listing
January 2019
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Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma: an analysis of the National Cancer Database.

Jpn J Clin Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, University of Louisville Hospital, Louisville KY, USA.

Objective(s): To identify predictors for receiving adjuvant radiation therapy (RT) and investigate the impact of adjuvant RT on survival for patients with resected primary tracheal carcinoma (PTC).

Methods: The National Cancer database was queried for patients with PTC diagnosed from 2004 to 2014 undergoing resection. Patients who died within 30 days of resection were excluded to minimize immortal time bias. Read More

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http://dx.doi.org/10.1093/jjco/hyz047DOI Listing
April 2019
28 Reads

Bioinspired and Biomimetic Nanomedicines.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Bioengineering , University of California , Los Angeles , California 90095 , United States.

Nanomedicine development aims to enhance the efficacy, accuracy, safety, and/or compliance of diagnosis and treatment of diseases by leveraging the unique properties of engineered nanomaterials. To this end, a multitude of organic and inorganic nanoparticles have been designed to facilitate drug delivery, sensing, and imaging, some of which are currently in clinical trials or have been approved by the Food and Drug Administration (FDA). In the process, the increasing knowledge in understanding how natural particulates, including cells, pathogens, and organelles, interact with body and cellular systems has spurred efforts to mimic their morphology and functions for developing new generations of nanomedicine formulations. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00079
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http://dx.doi.org/10.1021/acs.accounts.9b00079DOI Listing
April 2019
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Metal-Organic Framework-Templated Biomaterials: Recent Progress in Synthesis, Functionalization, and Applications.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Institute of Functional Interfaces , Karlsruhe Institute of Technology , Hermann-von Helmholtz-Platz 1 , D-76344 Eggenstein-Leopoldshafen , Germany.

The integration of a porous crystalline framework with soft polymers to create novel biomaterials has tremendous potential yet remains very challenging to date. Metal-organic framework (MOF)-templated polymers (MTPs) have emerged as persistent modular materials that can be tailored for desired biofunctions. These represent a novel class of hierarchically structured assemblies that combine the advantages of MOFs (precisely controlled structure, enormous diversity in framework topology, and high porosity) with the intrinsic behaviors of polymers (soft texture, flexibility, biocompatibility, and improved stability under physiological conditions). Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00039
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http://dx.doi.org/10.1021/acs.accounts.9b00039DOI Listing
April 2019
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Semiconducting Perylene Diimide Nanostructure: Multifunctional Phototheranostic Nanoplatform.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Laboratory of Molecular Imaging and Nanomedicine (LOMIN) , National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda , Maryland 20892 , United States.

Precision medicine requires noninvasive and accurate early diagnosis and individually appropriate treatments. Phototheranostics has been considered a frontier precision medical technology to provide rapid and safe disease localization and efficient cure. Harnessing the power of advanced nanomedicine with photonics, phototheranostics is rapidly developing and progressively becoming irreplaceable in modern medicine. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00064
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http://dx.doi.org/10.1021/acs.accounts.9b00064DOI Listing
April 2019
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Metastasis of submandibular gland carcinoma to the toe bone: a case report.

Br J Oral Maxillofac Surg 2019 Apr 8. Epub 2019 Apr 8.

Department of Orthopedics Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, 12 Health Road, Shijiazhuang, Hebei 050011, PR China. Electronic address:

Adenoid cystic carcinoma (ACC) is rare. One of its characteristics is a high rate of distant metastasis, and the most common site is the lungs, followed by the brain and liver. Bony metastases account for up to 1. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.03.011DOI Listing
April 2019
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Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin.

Microb Cell Fact 2019 Apr 11;18(1):71. Epub 2019 Apr 11.

Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, 52425, Jülich, Germany.

Background: In the last years, different biotechnologically relevant microorganisms have been engineered for the synthesis of plant polyphenols such as flavonoids and stilbenes. However, low intracellular availability of malonyl-CoA as essential precursor for most plant polyphenols of interest is regarded as the decisive bottleneck preventing high product titers.

Results: In this study, Corynebacterium glutamicum, which emerged as promising cell factory for plant polyphenol production, was tailored by rational metabolic engineering towards providing significantly more malonyl-CoA for product synthesis. Read More

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http://dx.doi.org/10.1186/s12934-019-1117-xDOI Listing

De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities.

Acc Chem Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute , University of California at San Francisco , San Francisco , California 94158-9001 , United States.

De novo protein design represents an attractive approach for testing and extending our understanding of metalloprotein structure and function. Here, we describe our work on the design of DF (Due Ferri or two-iron in Italian), a minimalist model for the active sites of much larger and more complex natural diiron and dimanganese proteins. In nature, diiron and dimanganese proteins protypically bind their ions in 4-Glu, 2-His environments, and they catalyze diverse reactions, ranging from hydrolysis, to O-dependent chemistry, to decarbonylation of aldehydes. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00674
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http://dx.doi.org/10.1021/acs.accounts.8b00674DOI Listing
April 2019
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Manipulating Spin Transition To Achieve Switchable Multifunctions.

Acc Chem Res 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Fine Chemicals , Dalian University of Technology , 2 Linggong Road , Dalian 116024 , P. R. China.

The spin transition of metal ions involves interconversion between electron configurations exhibiting considerably different functions and plays a substantial role in the chemical, physical, and biological fields. The photoinduced spin transition offers a promising approach to tune various physical properties with high spatial and temporal resolutions for producing smart multifunctional materials not only to explore their basic science but also to satisfy the demands of the next-generation photoswitchable-molecule-based devices. Therefore, it is attracting considerable interest to utilize photoinduced spin transition to simultaneously tune multifunctions. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00049DOI Listing