Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells.
- Mohammed A Kassem,
- Mohamed A Megahed,
- Sherif K Abu Elyazid,
- Fathy I Abd-Allah,
- Tamer M Abdelghany,
- Ahmed M Al-Abd,
- Khalid M El-Say
AAPS PharmSciTech 2018 Feb 22. Epub 2018 Feb 22.
Department of Pharmaceutics and Industrial Pharmacy, Al-Azhar University, Cairo, Egypt.
Serious adverse effects and low selectivity to cancer cells are the main obstacles of long term therapy with Tamoxifen (Tmx). This study aimed to develop Tmx-loaded span-based nano-vesicles for delivery to malignant tissues with maximum efficacy. The effect of three variables on vesicle size (Y), zeta potential (Y), entrapment efficiency (Y) and the cumulative percent release after 24 h (Y) were optimized using Box-Behnken design. Read More