Search our Database of Scientific Publications and Authors

I’m looking for a

    2460 results match your criteria AAPS PharmSciTech[Journal]

    1 OF 50

    Enhancement of Galantamine HBr Skin Permeation Using Sonophoresis and Limonene-Containing PEGylated Liposomes.
    AAPS PharmSciTech 2017 Nov 22. Epub 2017 Nov 22.
    Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, 350-0295, Japan.
    This study aimed to investigate the effect of low-frequency sonophoresis (SN) and limonene-containing PEGylated liposomes (PL) on the transdermal delivery of galantamine HBr (GLT). To evaluate the skin penetration mechanism, confocal laser scanning microscopy (CLSM), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) were employed. The application of SN led to more GLT penetration into and through the skin than GLT solution alone. Read More

    Fullerenol-Based Intracellular Delivery of Methotrexate: A Water-Soluble Nanoconjugate for Enhanced Cytotoxicity and Improved Pharmacokinetics.
    AAPS PharmSciTech 2017 Nov 20. Epub 2017 Nov 20.
    Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandar Sindri, Dist., Ajmer, Rajasthan, 305817, India.
    Derivatization of fullerenes to polyhydroxylated fullerenes, i.e., fullerenols (FLU), dramatically decreases their toxicity and has been reported to enhance the solubility as well as cellular permeability. Read More

    Fluidized Bed Hot-Melt Granulation as a Tool to Improve Curcuminoid Solubility.
    AAPS PharmSciTech 2017 Nov 16. Epub 2017 Nov 16.
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Instituto Nacional de Ciência e Tecnologia-INCT-Nanotecnologia Farmacêutica, Universidade de São Paulo, Via do Café s/n, Campus USP, Ribeirão Preto, SP, 14040-903, Brazil.
    Curcumin is the main bioactive component of Curcuma longa L. and has recently aroused growing interest from the scientific community. Unfortunately, the medicinal properties attributed to curcuminoids are impaired by their low oral bioavailability or low solubility in aqueous solutions. Read More

    An Optimized and Feasible Preparation Technique for the Industrial Production of Hydrogel Patches.
    AAPS PharmSciTech 2017 Nov 16. Epub 2017 Nov 16.
    Fengyuan Pharmaceutical Limited Company, 044600, Ruicheng, People's Republic of China.
    For hydrogel patches, the laboratory tests could not fully reveal the existing problems of full scale of industrial production, and there are few studies about the preparation technique for the industrial manufacturing process of hydrogel patches. So, the purpose of this work was to elucidate the effects of mainly technological operation and its parameters on the performance of hydrogel patches at the industrial-scale production. The results revealed the following: (1) the aqueous phase was obtained by polyvinylpyrrolidone (PVP) along with tartaric acid dissolved in purified water, then feeding this into a vacuum mixer as a whole in one batch, thus extended the crosslinking reaction time of hydrogel paste (matrix) and allowed the operation of coating/cutting-off to be carried out easily, and there was no permeation of backing layer; (2) the gel strength of the hydrogel patches increased with the increase of working temperature, however, once the temperature exceeded 35 ± 2 °C, the hydrogel paste would lose water severely and the resultant physical crosslinking structure which has lower gel/cohesive strength would easily bring gelatinization/residues during application; (3) the relative humidity (RH) of the standing-workshop was dynamically controlled (namely at 35 ± 2 °C, keeping the RH at 55 ± 5% for 4 days, then 65 ± 5% for 2 days), which would make patches with satisfactory characteristics such as better flexibility, higher adhesive force, smooth flat matrix surface, and without gelatinization/residues and warped edge during the using process; (4) the aging of the packaged hydrogel patches was very sensitive to storage temperature, higher temperature, higher gel strength and lower adhesiveness. Read More

    Optimized Ciclopirox-Based Eudragit RLPO Nail Lacquer: Effect of Endopeptidase Enzyme as Permeation Enhancer on Transungual Drug Delivery and Efficiency Against Onychomycosis.
    AAPS PharmSciTech 2017 Nov 14. Epub 2017 Nov 14.
    Pharmaceutic Department, National Organization for Drug Control and Research, Giza, Egypt.
    The aims of our investigation were to develop and optimize ciclopirox (CPX) nail lacquer using nonbiodegradable Eudragit RLPO (E-RLPO) as a film former and to assess its penetration efficiency across the human nail plate. Preliminary trials such as hydration enhancement factor (HEF), a retained drug in the nail plate, and SEM were studied to select the optimized permeation enhancer to be incorporated in the optimized lacquer formulation. A 3(3) full factorial design was built up to study the effect of three different factors, concentration of E-RLPO (10, 20, and 30%), Tween 80 (0. Read More

    Investigation on Secondary Structure Perturbations of Proteins Embedded in Solid Lipid Matrices as a Novel Indicator of their Biological Activity upon In Vitro Release.
    AAPS PharmSciTech 2017 Oct 6. Epub 2017 Oct 6.
    School of Pharmacy, University of Otago, Dunedin, New Zealand.
    Protein biologics are prone to conformational changes during formulation development. Limited methods are available for conformational analysis of proteins in solid state and in the presences of formulation excipients. The aim of this study was to investigate the secondary structures of proteins encased in solid lipid matrices as a novel indicator of their stability upon in vitro release. Read More

    Experimental and Computational Comparative Study of the Supercritical Fluid Technology (SFT) and Kneading Method in Preparing β-Cyclodextrin Complexes with Two Essential Oils (Linalool and Carvacrol).
    AAPS PharmSciTech 2017 Nov 13. Epub 2017 Nov 13.
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan.
    Supercritical fluid technology (SFT) offers many advantages as a potential complexation method compared to the conventional kneading technique. Its applicability to processess in which solvents are not required is a significant benefit. The main aim of this study was to evaluate, experimentally and computationally, the applicability of SFT in the preparation of β-cyclodextrin complexes with two selected essential oils, namely, carvacrol and linalool. Read More

    Correction to: Drug Delivery from an Innovative LAMA/LABA Co-suspension Delivery Technology Fixed-Dose Combination MDI: Evidence of Consistency, Robustness, and Reliability.
    AAPS PharmSciTech 2017 Nov 9. Epub 2017 Nov 9.
    Pearl Therapeutics Inc., 4222 Emperor Blvd, Suite 560, Durham, North Carolina, 27703, USA.
    This article was originally published Online First without open access. After publication it was discovered that the author had ordered open access during the production process. The incorrect license was assigned to this paper due to a technical error. Read More

    Evaluation of Efficiency of Modified Polypropylenimine (PPI) with Alkyl Chains as Non-viral Vectors Used in Co-delivery of Doxorubicin and TRAIL Plasmid.
    AAPS PharmSciTech 2017 Nov 7. Epub 2017 Nov 7.
    Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    In this study, co-delivery system was achieved via plasmid encoding TNF related apoptosis inducing ligand (pTRAIL) and doxorubicin (DOX) using carrier based on polypropylenimine (PPI) modified with 10-bromodecanoic acid. Incorporation of alkylcarboxylate chain to PPIs (G4 and G5) could improve transfection efficiency via overcoming the plasma membrane barrier of the cells and decrease cytotoxicity of PPI. Characterization of fabricated NPs revealed that PPI G5 in which 30% of primary amines were substituted by alkyl carboxylate chain (PPI G5-Alkyl 30%) has higher drug loading as compared to the other formulations. Read More

    Chemometric Methods to Quantify 1D and 2D NMR Spectral Differences Among Similar Protein Therapeutics.
    AAPS PharmSciTech 2017 Nov 6. Epub 2017 Nov 6.
    Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, St. Louis, Missouri, 63110, USA.
    NMR spectroscopy is an emerging analytical tool for measuring complex drug product qualities, e.g., protein higher order structure (HOS) or heparin chemical composition. Read More

    Evaluation of Streptococcus thermophilus IFFI 6038 Microcapsules Prepared Using an Ultra-fine Particle Processing System.
    AAPS PharmSciTech 2017 Nov 6. Epub 2017 Nov 6.
    School of Pharmaceutical Sciences, Sun Yat-Sen University, No.132, Waihuan East Road, Guangzhou Higher Education Mega Center, Guangzhou, 510006, People's Republic of China.
    Microencapsulation technology has the potential to protect probiotics and to deliver them to the gut, and extrusion is one of the most commonly used methods. However, the rather large diameters of 1~5 mm produced tend to cause oral grittiness and result in low compliance. In this article, Streptococcus thermophilus IFFI 6038 (IFFI 6038) microcapsules were prepared using an ultra-fine particle processing system (UPPS) previously developed by this research group. Read More

    Development of Chitosan-Based pH-Sensitive Polymeric Micelles Containing Curcumin for Colon-Targeted Drug Delivery.
    AAPS PharmSciTech 2017 Nov 6. Epub 2017 Nov 6.
    Pharmaceutical Development of Green Innovations Group (PDGIG) Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand.
    pH-sensitive N-naphthyl-N,O-succinyl chitosan (NSCS) and N-octyl-N,O-succinyl chitosan (OSCS) polymeric micelles carriers have been developed to incorporate curcumin (CUR) for colon-targeted drug delivery. The physical entrapment methods (dialysis, co-solvent evaporation, dropping, and O/W emulsion) were applied. The CUR-loaded micelles prepared by the dialysis method presented the highest loading capacity. Read More

    Non-ionic Surfactant Based In Situ Forming Vesicles as Controlled Parenteral Delivery Systems.
    AAPS PharmSciTech 2017 Nov 6. Epub 2017 Nov 6.
    Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, End of 90th street, Fifth settlement, New Cairo, Egypt.
    Non-ionic surfactant (NIS) based in situ forming vesicles (ISVs) present an affordable alternative to the traditional systems for the parenteral control of drug release. In this work, NIS based ISVs encapsulating tenoxicam were prepared using the emulsion method. Tenoxicam-loaded ISVs were prepared using a 2(2). Read More

    Process Analytical Technology in Freeze-Drying: Detection of the Secondary Solute + Water Crystallization with Heat Flux Sensors.
    AAPS PharmSciTech 2017 Nov 3. Epub 2017 Nov 3.
    Pharmaceutical Development, Allergan plc, Irvine, California, 92612, USA.
    In situ and non-invasive detection of solute crystallization during freeze-drying would facilitate cycle optimization and scale-up from the laboratory to commercial manufacturing scale. The objective of the study is to evaluate heat flux sensor (HFS) as a tool for monitoring solute crystallization and other first-order phase transitions (e.g. Read More

    Melts of Octaacetyl Sucrose as Oral-Modified Release Dosage Forms for Delivery of Poorly Soluble Compound in Stable Amorphous Form.
    AAPS PharmSciTech 2017 Nov 2. Epub 2017 Nov 2.
    Institute of Technology, Faculty of Mathematics, Physics and Technical Science, Pedagogical University of Cracow, ul. Podchorążych 2, 30-084, Kraków, Poland.
    The presented work describes the formulation and characterization of modified release glassy solid dosage forms (GSDFs) containing an amorphous nifedipine, as a model BCS (Biopharmaceutical Classification System) class II drug. The GSDFs were prepared by melting nifedipine together with octaacetyl sucrose. Dissolution profiles, measured under standard and biorelevant conditions, were compared to those obtained from commercially available formulations containing nifedipine such as modified release (MR) tablets and osmotic release oral system (OROS). Read More

    Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior.
    AAPS PharmSciTech 2017 Nov 2. Epub 2017 Nov 2.
    Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
    There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. Read More

    Improving Solubility and Oral Bioavailability of Febuxostat by Polymer-Coated Nanomatrix.
    AAPS PharmSciTech 2017 Oct 27. Epub 2017 Oct 27.
    Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
    Here, the mesoporous silica (Sylysia 350) was selected as mesoporous material, hydroxypropyl methylcellulose (HPMC) was selected as crystallization inhibitor, and febuxostat (FBT) was selected as model drug, respectively. The FBT-Sylysia-HPMC nanomatrix (FBT@SHN) was prepared. The characteristics of FBT@SHN were investigated in vitro and in vivo. Read More

    Characterization of the Dissolution Behavior of Piperine/Cyclodextrins Inclusion Complexes.
    AAPS PharmSciTech 2017 Oct 25. Epub 2017 Oct 25.
    Laboratory of Drug Safety Management, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama, 350-0295, Japan.
    In this study, the physicochemical properties and solubility of inclusion complexes of ground mixtures (GMs) of piperine (PP), a pungent ingredient of pepper, with α- and γ-cyclodextrin (CD) were studied. From the solubility results, the PP/αCD inclusion molar ratio was determined to be 1/2, while that of PP/γCD was 1/1, according to the AP-type phase diagram of PP/αCD and the BS-type one of PP/γCD. The powder X-ray diffraction and differential scanning calorimetry analyses confirmed the formation of GM complexes with molar ratios of PP/αCD = 1/2 and PP/γCD = 1/1. Read More

    The Relationship Between the Permeability and the Performance of Carrier-Based Dry Powder Inhalation Mixtures: New Insights and Practical Guidance.
    AAPS PharmSciTech 2017 Oct 23. Epub 2017 Oct 23.
    Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, El-Khartoum Square, El-Azarita, Alexandria, 21521, Egypt.
    The permeability of a powder bed reflects its particle size distribution, shape, packing, porosity, cohesivity, and tensile strength in a manner relevant to powder fluidization. The relationship between the permeability and the performance of carrier-based dry powder inhalation (DPI) mixtures has, however, aroused controversy. The current study sought to gain new insights into the relationship and to explore its potential applications. Read More

    Effect of Arginine on the Aggregation of Protein in Freeze-Dried Formulations Containing Sugars and Polyol: 1-Formulation Development.
    AAPS PharmSciTech 2017 Oct 18. Epub 2017 Oct 18.
    Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK.
    L-arginine was introduced into protein-based freeze-dried formulations to study the ability of arginine to reduce/prevent from protein aggregation during manufacturing, storage and reconstitution of lyophilized protein-based pharmaceuticals. As L-arginine is known to be very hygroscopic, additional excipients which could provide a moisture buffering capacity need to be introduced into the formulation. In the first part of our study-excipient formulation development-the screening of a number of sugars/polyols has been done in order to select the best combination of excipients that, in a complex with L-arginine, can (i) produce freeze-dried cakes with elegant appearance, adequate mechanical properties and reconstitution times, and (ii) resist/minimise the moisture sorption. Read More

    Liquid Nanosize Emulsion-Filled Enteric-Coated Capsules for Colon Delivery of Immunosuppressant Peptide.
    AAPS PharmSciTech 2017 Oct 17. Epub 2017 Oct 17.
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
    Present study aims at solubilizing slightly water-soluble peptide into a nanosize emulsion which is filled into a hard gelatin capsule in the form of preconcentrate. Further, liquid-filled capsule was dip-coated with ethyl cellulose and Eudragit S100 for colon targeting. An in vitro release profile was studied for selected formulations, i. Read More

    First Steps towards the Pharmaceutical Development of Ovules Containing Lactobacillus Strains: Viability and Antimicrobial Activity as Basic First Parameters in Vaginal Formulations.
    AAPS PharmSciTech 2017 Oct 17. Epub 2017 Oct 17.
    Area Bacteriología, Departamento de Microbiología e Inmunología, Facultad Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), 5800, Río Cuarto, Córdoba, Argentina.
    In the majority of Latin-American countries, including Argentina, there is a limited availability of vaginal bioproducts containing probiotics in the market. In addition, the conventional treatments of genital tract infections in women represent a high cost to the public health systems. The future development of this type of bioproducts that employ specific lactobacilli strains would not only have a meaningful impact on women's health but would also represent a significant challenge to the pharmaceutical industry. Read More

    Development and Optimization of a Starch-Based Co-processed Excipient for Direct Compression Using Mixture Design.
    AAPS PharmSciTech 2017 Oct 16. Epub 2017 Oct 16.
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, Punjab, 160 062, India.
    The development of novel excipients with enhanced functionality has been explored using particle engineering by co-processing. The aim of this study was to improve the functionality of tapioca starch (TS) for direct compression by co-processing with gelatin (GEL) and colloidal silicon dioxide (CSD) in optimized proportions. Design of Experiment (DoE) was employed to optimize the composition of the co-processed excipient using the desirability function and other supporting studies as a basis for selecting the optimized formulation. Read More

    Preparation and Evaluation of Artemether Liposomes for Enhanced Anti-Tumor Therapy.
    AAPS PharmSciTech 2017 Oct 16. Epub 2017 Oct 16.
    School of Pharmaceutical Sciences, Shandong University, 44 Wenhua Xi Road, Ji'nan, 250012, Shandong Province, People's Republic of China.
    The aim of the study was to design liposomes (Lips) of artemether (ARM), a plant-derived drug for treatment of metastatic tumors, for the intravenous delivery. The ARM-Lips were prepared using ethanol injection method. Based on the optimization of formulation with single-factor experiments, ARM-Lips were spherical with a uniform particle size (187. Read More

    Cubic Liquid Crystalline Gels Based on Glycerol Monooleate for Intra-articular Injection.
    AAPS PharmSciTech 2017 Oct 12. Epub 2017 Oct 12.
    Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, China.
    In situ gels containing sinomenine hydrochloride (SMH) for intra-articular (IA) administration to treat rheumatoid arthritis (RA) were designed and investigated in this study. Glycerol monooleate (GMO) was used due to the potential to generate viscous crystalline phase structures upon water absorption. The gels were evaluated using different parameters: syringeability, gelation, viscosity, and drug release. Read More

    Quality Issues Identified During the Evaluation of Biosimilars by the European Medicines Agency's Committee for Medicinal Products for Human Use.
    AAPS PharmSciTech 2017 Oct 12. Epub 2017 Oct 12.
    Medicines Authority, Sir Temi Zammit Buildings, Malta Life Sciences Park, San Ġwann, SGN 3000, Malta.
    The aim of this study was to identify trends in deficiencies raised during the EU evaluation of the quality part of dossiers for marketing authorisation applications of biosimilar medicinal products. All adopted day 120 list of questions on the quality module of 22 marketing authorisation applications for biosimilars submitted to the European Medicines Agency and concluded by the end of October 2015 was analysed. Frequencies of common deficiencies identified were calculated and summarised descriptions included. Read More

    Drug Delivery from an Innovative LAMA/LABA Co-suspension Delivery Technology Fixed-Dose Combination MDI: Evidence of Consistency, Robustness, and Reliability.
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    Pearl Therapeutics Inc., 4222 Emperor Blvd, Suite 560, Durham, North Carolina, 27703, USA.
    To ensure consistency of clinical outcomes, orally inhaled therapies must exhibit consistent delivered dose and aerosol properties at the time of manufacturing, throughout storage, and during various patient-use conditions. Achieving consistency across these scenarios has presented a significant challenge, especially for combination products that contain more than one drug. This study characterized the delivered dose and aerosol properties of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI; Bevespi Aerosphere™). Read More

    Bulk Freeze-Drying Milling: a Versatile Method of Developing Highly Porous Cushioning Excipients for Compacted Multiple-Unit Pellet Systems (MUPS).
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore.
    The compaction of multiple-unit pellet system (MUPS) is a challenging process due to the ease of coat damage under high compression pressure, thereby altering drug release rates. To overcome this, cushioning excipients are added to the tablet formulation. Excipients can be processed into pellets/granules and freeze-dried to increase their porosity and cushioning performance. Read More

    Formulation and Pharmacokinetics of HSA-core and PLGA-shell Nanoparticles for Delivering Gemcitabine.
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua Road No. 103, Shenyang, China.
    Gemcitabine-loaded core-shell nanoparticles (CSNPs), comprised of a cross-linked HSA-core and PLGA-shell, were prepared through a modified double emulsification method, and the processing parameters were systematically investigated. The optimized CSNPs had a particle size of 241 ± 36.2 nm and an encapsulation efficiency of 41. Read More

    Microbial Stability of Pharmaceutical and Cosmetic Products.
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    Department of Pharmaceutics and Drug Delivery, University of Mississippi School of Pharmacy, University, MS, 38677, USA.
    This review gives a brief overview about microbial contamination in pharmaceutical products. We discuss the distribution and potential sources of microorganisms in different areas, ranging from manufacturing sites, pharmacy stores, hospitals, to the post-market phase. We also discuss the factors that affect microbial contamination in popular dosage forms (e. Read More

    Cholecalciferol-PEG Conjugate Based Nanomicelles of Doxorubicin for Treatment of Triple-Negative Breast Cancer.
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, 32307, USA.
    Triple-negative breast cancer (TNBC) is the leading cancer in women. Chemotherapeutic agents used for TNBC are mainly associated with dose-dependent toxicities and development of resistance. Hence, novel strategies to overcome resistance and to offer dose reduction are warranted. Read More

    Release Mechanism Between Ion Osmotic Pressure and Drug Release in Ionic-Driven Osmotic Pump Tablets (I).
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
    The objective of this study was to develop an authentic ionic-driven osmotic pump system and investigate the release mechanism, simultaneously exploring the in vitro and in vivo correlation of the ionic-driven osmotic pump tablet. A comparison of the ionic-driven and conventional theophylline osmotic pump, the influence of pH and the amount of sodium chloride on drug release, the relationship between the ionic osmotic pressure and the drug release, and the pharmacokinetics experiment in beagle dogs were investigated. Consequently, the similarity factor (f 2 ) between the novel and conventional theophylline osmotic pump tablet was 60. Read More

    Systematical Investigation of Different Drug Nanocrystal Technologies to Produce Fast Dissolving Meloxicam Tablets.
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    Institute of Pharmacy, Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universität Berlin, Berlin, Germany.
    Three different methods, i.e., high-pressure homogenization, wet bead milling, and a combination approach of freeze-drying and high-pressure homogenization, were used to produce meloxicam nanosuspensions, respectively. Read More

    Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery.
    AAPS PharmSciTech 2017 Oct 10. Epub 2017 Oct 10.
    Faculdade de Ciências Farmacêuticas, Departamento de Fármacos e Medicamentos, UNESP-Universidade Estadual Paulista, Campus Araraquara, Araraquara, SP, 14800-850, Brazil.
    The buccal mucosa is accessible, shows rapid repair, has an excellent blood supply, and shows the absence of the first-pass effect, which makes it a very attractive drug delivery route. However, this route has limitations, mainly due to the continuous secretion of saliva (0.5 to 2 L/day), which may lead to dilution, possible ingestion, and unintentional removal of the active drug. Read More

    Improved Oral Bioavailability and Liver Targeting of Sorafenib Solid Lipid Nanoparticles in Rats.
    AAPS PharmSciTech 2017 Oct 5. Epub 2017 Oct 5.
    Department of Infectious Diseases, The Second Affiliated Hospital of Nanchang University, School of Pharmaceutical Science, Nanchang University, Nanchang, 330006, People's Republic of China.
    Minimal information is available on the oral bioavailability and liver-targeting properties of sorafenib solid lipid nanoparticles (SRF-SLNs) in rats. In this study, SRF-SLNs were prepared via the combined methods of high-speed shearing and ultrasonic treatment. SRF-SLN formulations were also optimized. Read More

    In Vivo Human Skin Penetration Study of Sunscreens by Confocal Raman Spectroscopy.
    AAPS PharmSciTech 2017 Oct 5. Epub 2017 Oct 5.
    Biomedical Engineering Innovation Center, Biomedical Vibrational Spectroscopy Group, Universidade Brasil-UNBr, Rua Carolina Fonseca, 235-08230-030, Itaquera, Sao Paulo, Brazil.
    This research work mainly deals with the application of confocal Raman spectroscopic technique to study in vivo human skin penetration of sunscreen products, as there are a lot of controversies associated with their skin penetration. Healthy human volunteers were tested for penetration of two commercial sunscreen products into their volar forearm skin for a period of 2 h. Measurements were taken before and after application of these sunscreen products. Read More

    Development of a New Aprepitant Liquisolid Formulation with the Aid of Artificial Neural Networks and Genetic Programming.
    AAPS PharmSciTech 2017 Oct 4. Epub 2017 Oct 4.
    Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
    In the present study, liquisolid formulations were developed for improving dissolution profile of aprepitant (APT) in a solid dosage form. Experimental studies were complemented with artificial neural networks and genetic programming. Specifically, the type and concentration of liquid vehicle was evaluated through saturation-solubility studies, while the effect of the amount of viscosity increasing agent (HPMC), the type of wetting (Soluplus® vs. Read More

    Enhanced Oral Bioavailability of Curcumin Using a Supersaturatable Self-Microemulsifying System Incorporating a Hydrophilic Polymer; In Vitro and In Vivo Investigations.
    AAPS PharmSciTech 2017 Oct 3. Epub 2017 Oct 3.
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand.
    A supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) with a reduced amount of surfactant and incorporation of a polymer precipitation inhibitor, Eudragit® E PO was developed. The optimized S-SMEDDS formulation (SS-15) consisted of 55% surfactants, 40% oils, and 5% Eudragit® E PO (curcumin at 44.4 mg/g of the formulation). Read More

    Investigation of Dissolution Behavior HPMC/Eudragit(®)/Magnesium Aluminometasilicate Oral Matrices Based on NMR Solid-State Spectroscopy and Dynamic Characteristics of Gel Layer.
    AAPS PharmSciTech 2017 Oct 2. Epub 2017 Oct 2.
    Department of Chemistry and Toxicology, Veterinary Research Institute, Brno, Czech Republic.
    Burst drug release is often considered a negative phenomenon resulting in unexpected toxicity or tissue irritation. Optimal release of a highly soluble active pharmaceutical ingredient (API) from hypromellose (HPMC) matrices is technologically impossible; therefore, a combination of polymers is required for burst effect reduction. Promising variant could be seen in combination of HPMC and insoluble Eudragits(®) as water dispersions. Read More

    In-Line Monitoring of a High-Shear Granulation Process Using the Baseline Shift of Near Infrared Spectra.
    AAPS PharmSciTech 2017 Oct 2. Epub 2017 Oct 2.
    Research Institute of Pharmaceutical Sciences, Musashino University, Nishitokyo-shi, Tokyo, Japan.
    Although near infrared (NIR) spectra are primarily influenced by undesired variations, i.e., baseline shifts and non-linearity, and many applications of NIR spectroscopy to the real-time monitoring of wet granulation processes have been reported, the granulation mechanisms behind these variations have not been fully discussed. Read More

    In vitro and In vivo Studies on a Novel Bioadhesive Colloidal System: Cationic Liposomes of Ibuprofen.
    AAPS PharmSciTech 2017 Oct 2. Epub 2017 Oct 2.
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
    The objective of this study was to develop an ocular drug delivery system built on the cationic liposomes, a novel bioadhesive colloidal system, which could enhance the precorneal residence time, ocular permeation, and bioavailability of ibuprofen. The optimal formulation of cationic liposomes prepared by ethanol injection method was ultimately confirmed by an orthogonal L9 (3(3)) test design. In addition, γ-scintigraphic technology and the microdialysis technique were utilized in the assessment of in vivo precorneal retention capability and ocular bioavailability individually. Read More

    Mixed Liposome Approach for Ratiometric and Sequential Delivery of Paclitaxel and Gemcitabine.
    AAPS PharmSciTech 2017 Oct 2. Epub 2017 Oct 2.
    Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907, USA.
    Paclitaxel (PTX) and gemcitabine (GEM) are often used in combination due to the synergistic anticancer effects. PTX and GEM combination showed a synergistic effect to SKOV-3 cells at a molar ratio of 1 to 1 and in PTX ➔ GEM sequence. Liposomes were explored as a carrier of PTX and GEM combination. Read More

    Preparation and Evaluation of Taste Masking Iron Suspension: Taking Advantage of Weak Cationic Exchange Resin.
    AAPS PharmSciTech 2017 Oct 2. Epub 2017 Oct 2.
    Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    The objective of this study is to use weak acid cation exchange resin to mask the taste and eliminate the teeth staining problems of ferrous sulfate liquid preparations for use in pediatrics. Amberlite IPR64 was loaded by Fe(II). Then, different suspensions of the iron-resin complex were prepared using various polymers as the suspending agents, and sorbitol as well as sucrose as sweeteners. Read More

    Evaluating Current Practices in Shelf Life Estimation.
    AAPS PharmSciTech 2017 Sep 25. Epub 2017 Sep 25.
    Statistics, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
    The current International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) methods for determining the supported shelf life of a drug product, described in ICH guidance documents Q1A and Q1E, are evaluated in this paper. To support this evaluation, an industry data set is used which is comprised of 26 individual stability batches of a common drug product where most batches are measured over a 24 month storage period. Using randomly sampled sets of 3 or 6 batches from the industry data set, the current ICH methods are assessed from three perspectives. Read More

    Comparative Pharmaceutical Evaluation of Candesartan and Candesartan Cilexetil: Physicochemical Properties, In Vitro Dissolution and Ex Vivo In Vivo Studies.
    AAPS PharmSciTech 2017 Sep 25. Epub 2017 Sep 25.
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, El-Khartoum Square, El-Azarita, Alexandria, 21521, Egypt.
    The aim of the present work is to answer the question is it possible to replace the ester prodrug candesartan cilexetil (CC) by its active metabolite candesartan (C) to bypass the in vivo variable effect of esterase enzymes. A comparative physicochemical evaluation was conducted through solubility, dissolution, and stability studies; additionally, ex vivo permeation and in vivo studies were assessed. C demonstrated higher solubility over CC at alkaline pH. Read More

    Regulatory Notes on Impact of Excipients on Drug Products and the Maillard Reaction.
    AAPS PharmSciTech 2017 Sep 25. Epub 2017 Sep 25.
    US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, 20993, USA.
    In general, it is an important criterion that excipients remain inert throughout the shelf life of the formulated pharmaceutical product. However, depending on the functionality in chemical structure of active drug and excipients, they may undergo interaction. The well-known Maillard reaction occurs between a primary amine with lactose at high temperature to produce brown pigments. Read More

    Darunavir-Loaded Lipid Nanoparticles for Targeting to HIV Reservoirs.
    AAPS PharmSciTech 2017 Sep 25. Epub 2017 Sep 25.
    Shri G.H. Patel Pharmacy Building, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, 390 002, India.
    Darunavir has a low oral bioavailability (37%) due to its lipophilic nature, metabolism by cytochrome P450 enzymes and P-gp efflux. Lipid nanoparticles were prepared in order to overcome its low bioavailability and to increase the binding efficacy of delivery system to the lymphoid system. Darunavir-loaded lipid nanoparticles were prepared using high-pressure homogenization technique. Read More

    Co-delivery of Vorinostat and Etoposide Via Disulfide Cross-Linked Biodegradable Polymeric Nanogels: Synthesis, Characterization, Biodegradation, and Anticancer Activity.
    AAPS PharmSciTech 2017 Sep 25. Epub 2017 Sep 25.
    Department of Chemistry, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi, 110003, India.
    Treatment regimens for cancer patients using single chemotherapeutic agents often lead to undesirable toxicity, drug resistance, reduced uptake etc. Combination of two or more drugs is therefore becoming an imperative strategy to overcome these limitations. A step forward can be taken through delivery of the drugs used in combination via nanoparticles. Read More

    Magnetic Nanoparticles for the Delivery of Dapagliflozin to Hypoxic Tumors: Physicochemical Characterization and Cell Studies.
    AAPS PharmSciTech 2017 Sep 18. Epub 2017 Sep 18.
    Department of Pharmacy, Medical School, University of Patras, 26504, Patras, Greece.
    In solid tumors, hypoxia (lack of oxygen) is developed, which leads to the development of resistance of tumor cells to chemotherapy and radiotherapy through various mechanisms. Nevertheless, hypoxic cells are particularly vulnerable when glycolysis is inhibited. For this reason, in this study, the development of magnetically targetable nanocarriers of the sodium-glucose transporter protein (SGLT2) inhibitor dapagliflozin (DAPA) was developed for the selective delivery of DAPA in tumors. Read More

    1 OF 50