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J Curr Glaucoma Pract 2020 Jan-Apr;14(1):30-36

Ophthalmology Department, Al-Azher University, Faculty of Medicine, Cairo, Egypt.

Background: To evaluate the intraocular pressure (IOP), anterior chamber angle (ACA), and globe biometric parameters in β-thalassemia major children and the correlations of these changes.

Materials And Methods: Eighty-four eyes were included (42 eyes of thalassemia patients and 42 eyes of control). All participates underwent head circumference and height measurements, full ophthalmic examination, anterior segment optical coherence tomography (AS-OCT), and A-scan biometry. Read More

Br J Ophthalmol 2020 Jun 10. Epub 2020 Jun 10.

Eye Clinic of Genoa, Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

Background/aims: To compare the accuracy of 13 formulas for intraocular lens (IOL) power calculation in cataract surgery.

Methods: In this retrospective interventional case series, optical biometry measurements were entered into these formulas: Barrett Universal II (BUII) with and without anterior chamber depth (ACD) as a predictor, EVO 2.0 with and without ACD as a predictor, Haigis, Hoffer Q, Holladay 1, Holladay 2AL, Kane, Næser 2, Pearl-DGS, RBF 2. Read More

Am J Obstet Gynecol 2020 Jun 3. Epub 2020 Jun 3.

Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

Background: Third-trimester scans are increasingly used to try to prevent adverse outcomes associated with abnormalities of fetal growth. Unexpected fetal malformations detected at third-trimester growth scans are rarely reported.

Objective: To determine the incidence and type of fetal malformations detected in women attending a routine third-trimester growth scan. Read More

Eur J Ophthalmol 2020 Apr 8:1120672120914536. Epub 2020 Apr 8.

University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.

Purpose: The aims of this study were to compare the biometric parameters and axial lengths of eyes with phacomorphic glaucoma and mature cataract and to identify differences that might predispose to development of phacomorphic glaucoma.

Methods: Three hundred forty-two patients were enrolled in this retrospective study. The eyes were divided into four groups-Group (G)1: phacomorphic glaucoma ( = 29), G2: mature cataract ( = 313), G3: contralateral phacomorphic glaucoma ( = 29), and G4: contralateral mature cataract ( = 313). Read More

Saudi J Ophthalmol 2019 Oct-Dec;33(4):342-346. Epub 2019 Jul 17.

Sagarmatha Choudhary Eye Hospital, Lahan - 3, Siraha, Nepal.

Purpose: To evaluate the anterior segment biometry characteristics in congenital cataract patients before undergoing surgery in a tertiary eye care centre.

Methods: We retrospectively reviewed the charts of congenital cataract patients aged less than 15 years who had undergone the congenital cataract surgery from Jan-Dec, 2015. 451 eyes of 351 patients were reviewed. Read More

J Prosthodont 2020 Apr 16;29(4):309-314. Epub 2019 Dec 16.

Department of Prosthodontics, University Hospital Erlangen, Glueckstraße 11, Erlangen, 91054, Germany.

Purpose: Sufficient data are not currently available on how the various geometries of scan bodies and different scan strategies affect the quality of digital impressions of implants. The purpose of this study was to present new data on these two topics and give clinicians a basis for decision making.

Materials And Methods: A titanium master model containing three Nobelreplace Select™ implants (Nobelbiocare Services AG, Zurich, Switzerland) was digitized using an ATOS industrial noncontact scanner. Read More

Invest Ophthalmol Vis Sci 2019 10;60(13):4319-4327

Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China.

Purpose: To investigate the effects of high ambient lighting on refraction and ocular biometry in guinea pig models of form-deprivation myopia (FDM).

Methods: Forty 3-week-old guinea pigs were randomly assigned to groups exposed to either high light (HL, 10,000 lux) or normal light (NL, 500 lux) with normal vision or form deprivation. Throughout the 10-week rearing period, animals were exposed to high light or normal light for 12 hours with a 12-hour light/dark cycle. Read More

Korean J Ophthalmol 2019 Oct;33(5):451-457

Department of Ophthalmology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: To describe current cataract surgery practice patterns and changing trends among Korean ophthalmologists.

Methods: A survey of members of the Korean Society of Cataract and Refractive Surgery was performed in July 2018. One hundred and two (12. Read More

Jpn J Ophthalmol 2019 Nov 14;63(6):467-473. Epub 2019 Sep 14.

Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.

Purpose: To evaluate the differences in ocular biometric parameters between eyes with primary angle closure (PAC) with and without visible ciliary body processes (CBP) (PAC+CBP and PAC-CBP) and normal open-angle controls.

Study Design: Cross-sectional study.

Methods: Eyes with PAC and normal open-angle controls underwent detailed ocular examinations and gonioscopy to determine the visibility of the CBP. Read More

Eur J Radiol 2019 Oct 7;119:108652. Epub 2019 Sep 7.

Department of Radiology, Peking University Third Hospital, Beijing, China. Electronic address:

Purpose: To evaluate the clinical value of ultralow-dose CT (ULDCT) with adaptive statistical iterative reconstruction-V (ASiR-V) in the detection of pulmonary nodules in a Chinese population.

Method: One hundred eighty-eight patients (16.41 ≤ BMI ≤ 29. Read More

Semin Ophthalmol 2019 1;34(5):392-397. Epub 2019 Jul 1.

b Department of Ophthalmology, University of Warmia and Mazury , Olsztyn , Poland.

Silicone oil (SO) is used mainly when managing complex retinal detachments, commonly with proliferative vitreoretinopathy, as well as a hemostatic agent in proliferative diabetic retinopathy. Combined lens exchange and pars plana vitrectomy remains preferred by many surgeons; however, sequential surgery might be advantageous to minimize the postoperative anterior chamber inflammatory response, particularly in proliferative diabetic retinopathy or retinal detachment. The aim of the study was to evaluate the optimal method of intraocular lens (IOL) calculation in eyes filled with SO. Read More

J Fr Ophtalmol 2019 Oct 1;42(8):874-879. Epub 2019 Jun 1.

Faculté de médecine de Tunis, université Tunis El Manar, hôpital Habib Thameur, 3, rue A. Ben Ayed, 1089 Tunis, Tunisie.

Goals: To describe the distribution of the central corneal thickness (CCT) in the Tunisian population.

Methods: A prospective descriptive study was performed in 201 right eyes of 201 randomly selected healthy Tunisian subjects without glaucoma. We measured the spherical error by autorefraction, the axial length using A-scan ultrasound biometry and the central corneal thickness using anterior segment optical coherence tomography (DRI TRITON OCT). Read More

Middle East Afr J Ophthalmol 2019 Jan-Mar;26(1):17-22

Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, New Zealand.

Purpose: To determine whether a biometry training course could improve refractive outcomes of patients undergoing manual small-incision extracapsular cataract surgery (SICS).

Materials And Methods: This was a prospective, interventional, cohort study at the Pacific Eye Institute, Fiji. SICS refractive outcomes were evaluated before and after a structured biometry teaching course. Read More

J Refract Surg 2019 May;35(5):333-339

Purpose: To evaluate the ocular biological parameter difference between scleral corneal cross-linking (CXL) and control eyes in rhesus monkeys by using a rebound tonometer, A-scan ultrasonography, retinoscopy, optical coherence tomography, and electroretinography (ERG).

Methods: Six rhesus monkeys were used in this study, with ages ranging from 3 to 3.5 years. Read More

Invest Ophthalmol Vis Sci 2019 03;60(4):1226-1233

Berkeley Myopia Research Group, Vision Science Program and School of Optometry, University of California, Berkeley, California, United States.

Purpose: To investigate differences in sensitivity to myopia-inducing stimuli of two strains of pigmented guinea pigs.

Methods: Eleven-day-old animals (New Zealand [NZ], n = 24 and Elm Hill strains [EH], n = 26) wore either a +2 or -2 diopter (D) lens over one eye and a plano lens over the fellow eye for 5 days; other 10-day-old EH (n = 9) and 7-day-old NZ (n = 9) animals were monocularly form-deprived (FD) for 28 days. Choroidal thickness and axial length were measured using A-scan ultrasonography at baseline and after 1 and 5 days for optical defocus treatments, and at baseline and after 28 days for the FD treatment. Read More

J Fr Ophtalmol 2019 Apr 21;42(4):e193-e194. Epub 2019 Mar 21.

Service d'Ophtalmologie, Hôpital militaire d'instruction Med-V, Rabat, Maroc.

BMC Ophthalmol 2019 Jan 24;19(1):30. Epub 2019 Jan 24.

Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: To evaluate the accuracy of biometric measurements by a swept-source optical coherence tomography (SS-OCT) based biometry for intraocular lens (IOL) power calculation.

Methods: This retrospective observational study enrolled 431 patients undergoing cataract surgery. The charts were reviewed to investigate the failure rate of axial length (AL) measurement of the SS-OCT biometer, partial coherence interferometry (PCI), and A-scan ultrasonography (US) according to cataract type and severity. Read More

Invest Ophthalmol Vis Sci 2019 01;60(1):98-106

Department of Ophthalmology, Medical School, University of Thessaly, Larissa, Greece.

Purpose: The purpose of this study was to prospectively investigate the association between retinopathy of prematurity (ROP) and ocular growth in premature infants during the earliest weeks of life.

Methods: Premature infants in the national ROP screening program were recruited and examined at 1- or 2-week intervals between 30 and 38 weeks of postmenstrual age. One hundred infants with gestational age (GA) between 24 and 35 weeks (30. Read More

Exp Eye Res 2019 03 27;180:250-259. Epub 2018 Dec 27.

Department of Ophthalmology and Visual Sciences, The University of Alabama at Birmingham, AL, USA. Electronic address:

We describe an analysis strategy to obtain ultrasonography-matched axial dimensions of small animal eyes using the LenStar biometer. The LenStar optical low-coherence reflectometer is an attractive device for animal research due to its high precision, non-invasiveness, and the ability to measure the axial dimensions of cornea, anterior chamber, lens, vitreous chamber, and axial length. However, this optical biometer was designed for clinical applications in human eyes and its internal analysis provides inaccurate values when used on small eyes due to species-dependent differences in refractive indices and relative axial dimensions. Read More

Invest Ophthalmol Vis Sci 2018 09;59(11):4631-4638

School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, State Key Laboratory of Optometry, Ophthalmology, and Vision Science, Wenzhou, Zhejiang, China.

Purpose: To determine if myopia in albino guinea pigs is linked to altered ocular dopamine (DA) levels in both the retinal and uveal dopaminergic systems.

Methods: Retina and retinal pigment epithelium (RPE)/choroid were dissected from eyes of 2-week-old albino myopic (AM) and pigmented hyperopic (PH) guinea pigs. The levels of DA, dihydroxy-phenyl acetic acid (DOPAC), and homovanillic acid (HVA) were determined. Read More

Korean J Ophthalmol 2018 08;32(4):257-264

Department of Ophthalmology, HanGil Eye Hospital, Incheon, Korea.

Purpose: To evaluate the agreement between optical biometry with swept-source optical coherence tomography-based optical biometry (IOLMaster 700) and other devices.

Methods: A total of 137 eyes (78 patients) with cataracts were included in this retrospective study. Axial length (AL), anterior chamber depth (ACD), keratometry, and white-to-white (WTW) distance measured using IOLMaster 700 were compared with results for the following five different biometers: IOLMaster 500, A-scan, automated refractor, manual keratometry, and Galilei G4. Read More

PLoS One 2018 23;13(7):e0199157. Epub 2018 Jul 23.

Hamilton Glaucoma Center, Department of Ophthalmology, Shiley Eye Institute, University of California-San Diego, La Jolla, California, United States of America.

Purpose: To classify subjects with primary angle closure into clusters based on features from anterior segment optical coherence tomography (ASOCT) imaging and to explore how these clusters correspond to disease subtypes, including primary angle closure suspect (PACS), primary angle closure glaucoma(PACG), acute primary angle closure (APAC) and fellow eyes of APAC and reveal the factors that become more predominant in each subtype of angle closure.

Method: A cross-sectional study of 248 eyes of 198 subjects(88 PACS eyes, 53 PACG eyes, 54 APAC eyes and 53 fellow eyes of APAC) that underwent complete examination including gonioscopy, A-scan biometry, and ASOCT. An agglomerative hierarchical clustering method was used to classify eyes based on ASOCT parameters. Read More

Clin Ophthalmol 2018 23;12:973-980. Epub 2018 May 23.

Vitreoretinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Purpose: We compared the accuracy of axial length (AL) measurement obtained by optical biometry with that obtained by acoustic biometry in eyes with rhegmatogenous retinal detachment (RRD).

Patients And Methods: This prospective descriptive analytic study measured the AL of eyes with RRD preoperatively and 3 months postoperatively using optical biometry (intraocular lens [IOL] master group) and acoustic biometry (immersion A-scan group). Preoperative and postoperative measurements were compared by paired -test. Read More

Exp Eye Res 2018 07 30;172:104-111. Epub 2018 Mar 30.

Section of Neurobiology of the Eye, Ophthalmic Research Institute, University of Tuebingen, Elfriede Aulhorn Strasse 7, 72076, Tuebingen, Germany. Electronic address:

Following a hypothesis raised by M. and J. Neitz, Seattle, we have tested whether the abundance and the ratio of Long wavelength-sensitive (L) to Middle wavelength-sensitive (M) cones may affect eye size and development of myopia in the chicken. Read More

J Glaucoma 2018 06;27(6):e110-e112

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Background: Crouzon syndrome is the most common form of craniosynostosis, and mutations in the fibroblast growth factor receptor 2 and 3 (FGFR2 and FGFR3) genes are implicated in its pathogenesis.

Observation: A 10-year-old female patient with Crouzon syndrome and congenital glaucoma treated with trabeculectomy and ocular hypotensive medications was examined. The patient had proptosis, exposure keratopathy, megalocornea, thin central corneal thickness, a shallow anterior chamber, mild anterior subcapsular cataract, and a cup-to-disc ratio of 0. Read More

Int J Ophthalmol 2018 18;11(2):274-278. Epub 2018 Feb 18.

Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.

Aim: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured optical coherence tomography (OCT) between different groups of myopia severity and controls.

Methods: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Read More

J Ophthalmol 2017 31;2017:9164846. Epub 2017 Dec 31.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Background: Retinitis pigmentosa (RP) comprises a group of inherited disorders in which patients typically lose night vision in adolescence and then lose peripheral vision in young adulthood before eventually losing central vision later in life. A retrospective case-control study was performed to evaluate differences in ocular biometric parameters in primary angle-closure glaucoma (PACG) patients with and without concomitant RP to determine whether a relationship exists between PACG and RP.

Methods: We used ultrasound biomicroscopy (UBM) to measure anterior chamber depth (ACD). Read More

J Pak Med Assoc 2018 Jan;68(1):81-84

Liaquat National Hospital, Karachi.

Objective: To evaluate the accuracy of biometry in the post-op phase of cataract surgery.

Methods: This study was conducted at Liaquat National Hospital, Karachi, from June 2015 to July 2016, and comprised the audit of patients who underwent cataract surgery during the period. Keratometry was done on Haag-Strait manual keratometer and A-scan was done by applanation contact method on SonoMed machine. Read More

J Ophthalmol 2017 15;2017:6823965. Epub 2017 Oct 15.

The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang 325027, China.

Purpose: To investigate the ocular parameters of premature infants without ROP at gestational age (GA) more than 28 weeks and their relationship with growth parameters.

Methods: 76 preterm infants without ROP and 65 term infants were involved to undergo portable slit lamp, RetCam3, ultrasonic A-scan biometry, and cycloplegic streak examination at their 40 weeks' postconceptional ages (PCA). Ocular parameters of infants' right eye and growth parameters were used for analysis. Read More

J Curr Glaucoma Pract 2017 Sep-Dec;11(3):86-91. Epub 2017 Oct 27.

Director Clinical Research, Department of Biostatistics, National Institute of Nutrition Hyderabad, Telangana, India.

Aim: To evaluate the configuration of the anterior chamber angle quantitatively and study the morphological changes in the eye with ultrasound biomicroscopy (UBM) in primary angle closure glaucoma (PACG) patients after laser peripheral iridotomy (LPI).

Materials And Methods: A total of 185 eyes of 185 PACG patients post-LPI and 126 eyes of 126 normal subjects were included in this prospective study. All subjects underwent complete ophthalmic evaluation, A-scan biometry, and UBM. Read More

Graefes Arch Clin Exp Ophthalmol 2017 Dec 3;255(12):2437-2442. Epub 2017 Oct 3.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: To quantitatively assess the biometry of the ciliary body in normal human eyes using ultrasound biomicroscopy.

Methods: We evaluated 85 eyes of 85 normal subjects (35 men and 50 women), whose age ranged from 11 to 86 years (mean ± SD, 56.8 ± 20. Read More

J Cataract Refract Surg 2017 06;43(6):767-773

From the Singapore Eye Research Institute (Atalay, Nongpiur, Baskaran, Perera, Wong, Aung), the Duke-NUS Graduate Medical School (Nongpiur, Baskaran, Wong), the Yong Loo Lin School of Medicine (Aung), National University of Singapore, and the Singapore National Eye Centre (Perera, Wong, Quek, Aung), Singapore, Singapore. Electronic address:

Purpose: To evaluate the intraocular pressure (IOP) change and associated factors 6 months after phacoemulsification in eyes with primary angle-closure suspect (PACS) and eyes with primary angle closure (PAC) that had no medical therapy.

Setting: Singapore National Eye Center, Singapore, Singapore.

Design: Retrospective case series. Read More

PLoS One 2017 12;12(6):e0178113. Epub 2017 Jun 12.

Institute of Genomic Medicine, Università Cattolica Del Sacro Cuore, Fondazione Policlinico A. Gemelli, Rome, Italy.

Objective: To investigate whether miscarried embryo/fetal crown rump length (CRL) measurement may yield a practical application for predicting a conclusive result at the cytogenetic analysis of miscarriage tissue. Our study might help in improving the cytogenetic method, the results of which may be affected by maternal cell contamination (MCC). In particular, we aimed at establishing whether the miscarried embryo/fetal CRL measurement shows accuracy in predicting the possibility of MCC and the scan cut-off value useful to this purpose and, as a result, suggest a multi-step procedure for the genetic ascertainment. Read More

Korean J Ophthalmol 2017 Apr 21;31(2):165-171. Epub 2017 Mar 21.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The aim of this study was to investigate the differences in anterior segment ocular parameters in anisometropia >1 D.

Methods: This study included 202 eyes of 101 subjects ranging from 10 to 40 years of age with anisometropia of 1 D or more. The subjects were divided into groups according to anisomyopia, anisoastigmatism, and anisohypermetropia. Read More

J Cataract Refract Surg 2017 01;43(1):74-79

From the Cullen Eye Institute (B.V. Ventura, Wang, Koch, Weikert), Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA; Altino Ventura Foundation (B.V. Ventura, M.C. Ventura), HOPE Eye Hospital (B.V. Ventura, M.C. Ventura), Recife, and the Department of Ophthalmology (B.V. Ventura), Federal University of São Paulo, São Paulo, Brazil.

Purpose: To compare biometry measurements and intraocular lens (IOL) power calculations obtained by a new optical A-scan interferometer biometer (Galilei G6) (new biometer) and a partial coherence interferometer biometer (IOLMaster 500) (reference biometer).

Setting: Private practice, Recife, Brazil.

Design: Retrospective comparative study. Read More

Turk J Ophthalmol 2017 Jan 17;47(1):28-33. Epub 2017 Jan 17.

Çanakkale Onsekiz Mart University Faculty of Medicine, Department of Ophthalmology, Çanakkale, Turkey.

Objectives: To compare retinal and optic disc characteristics between amblyopic and non-amblyopic eyes in patients with myopic and hyperopic anisometropia measured with optical coherence tomography (OCT).

Materials And Methods: Patients with myopic (25 patients: 17 female, 8 male; median age 27 years, range 16-40 years) and hyperopic (31 patients: 19 female, 12 male; median age 20 years, range 13-41 years) anisometropic amblyopia were included. Eye examination included determination of best-corrected visual acuity (BCVA) with a Snellen chart, measurement of manifest and cycloplegic refraction after pupillary dilation, alternate cover testing, globe movement evaluation, A-scan biometry for axial length, biomicroscopy, fundus examination, and OCT scanning. Read More

J Nucl Med 2017 07 19;58(7):1104-1110. Epub 2017 Jan 19.

Molecular Nutritional Medicine, ZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany; and.

Brown adipose tissue (BAT) provides a means of nonshivering thermogenesis. In humans, active BAT can be visualized by F-FDG uptake as detected by PET combined with CT. The retrospective analysis of clinical scans is a valuable source to identify anthropometric parameters that influence BAT mass and activity and thus the potential efficacy of envisioned drugs targeting this tissue to treat metabolic disease. Read More

Bone 2017 04 27;97:43-48. Epub 2016 Dec 27.

Department of Radiology, Cumming School of Medicine, University of Calgary, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Canada. Electronic address:

Objective: High-resolution peripheral quantitative computed tomography (HR-pQCT) is a novel imaging modality capable of visualizing bone microarchitecture in vivo at human peripheral sites such as the distal radius and distal tibia. This research has extended the technology to provide a non-invasive assessment of bone microarchitecture at the human knee by establishing new hardware, imaging protocols and data analysis.

Design: A custom leg holder was developed to stabilize a human knee centrally within a second generation HR-pQCT field of view. Read More

Eye Contact Lens 2018 Sep;44 Suppl 1:S115-S117

Department of Ophthalmology (R.A., S.K.E.), Istanbul Medipol University, Istanbul, Turkey; Department of Ophthalmology (K.S.C.), Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey; Department of Ophthalmology (E.K.), Bati Göz Hospital, Izmir, Turkey; and Department of Ophthalmology (S.K.), Dokuz Eylul University, Izmir, Turkey.

Purpose: To compare anterior chamber depth (ACD), axial length (AL), and lens thickness (LT) measurements obtained by the Lenstar LS 900 (Haag-Streit AG) optical low-coherence reflectometry with those obtained by the A-scan contact ultrasound among patients with moderate and high hypermetropia.

Methods: Fifty-two eyes of 52 patients with moderate and high hypermetropia (spherical equivalent of +4 D or more) were examined in this study measurements of ACD, AL, and LT obtained by Lenstar were compared with those obtained by applanation A-scan ultrasound. All measurements were obtained by two independent examiners. Read More

J Curr Ophthalmol 2016 Dec 12;28(4):170-175. Epub 2016 Jul 12.

Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.

Purpose: To evaluate different mechanisms of primary angle closure (PAC) and to quantify anterior chamber (AC) parameters in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT).

Methods: In this prospective study, 115 eyes of 115 patients with angle closure disease were included and categorized into three groups: 1) fellow eyes of acute angle closure (AAC; 40 eyes); 2) primary angle closure glaucoma (PACG; 39 eyes); and 3) primary angle closure suspect (PACS; 36 eyes). Complete ophthalmic examination including gonioscopy, A-scan biometry, and AS-OCT were performed. Read More

J Glaucoma 2017 Feb;26(2):153-158

*Koret Vision Center, San Francisco Medical School, University of California, San Francisco, CA †Farabi Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran ‡Departments of Ophthalmology, University of Melbourne, Melbourne, Vic., Australia.

Purpose: To quantitatively analyze the anterior chamber parameters in patients with pupillary block (PB) and plateau iris configuration (PIC) using anterior segment optical coherence tomography (ASOCT).

Patients And Methods: In this cross-sectional study, nonglaucomatous subjects consecutively recruited and a total of 212 eyes divided into 3 groups of PIC (31 eyes), PB (60 eyes), and open angles (121 eyes) based on gonioscopic and ultrasound biomicroscopy findings. All patients underwent ASOCT imaging and A-scan biometry of both eyes. Read More

Int J Ophthalmol 2016 18;9(10):1521-1523. Epub 2016 Oct 18.

2nd Department of Ophthalmology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki 56429, Greece.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5320-5325

Singapore Eye Research Institute, Singapore 3Singapore National Eye Centre, Singapore 4Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Purpose: To compare ocular biometric and anterior segment parameters between the affected and fellow eye in subjects with acute primary angle closure (APAC).

Methods: We evaluated 76 subjects with unilateral APAC who had undergone bilateral laser peripheral iridotomy before enrollment. Imaging was done using anterior segment optical coherence tomography and a customized software was used to measure the following: angle opening distance (AOD750); trabecular-iris space area (TISA750); iris thickness (IT750); iris curvature (ICURV); iris area (IAREA); anterior chamber depth; area and volume (ACD; ACA and ACV); anterior chamber width (ACW); anterior vault (ACD+LV); lens vault (LV); and pupil diameter (PD). Read More

Int Ophthalmol 2017 Aug 13;37(4):849-858. Epub 2016 Sep 13.

Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli, 620001, Tamil Nadu, India.

Purpose: To compare data on anatomical and biometric parameters, and their combination, obtained by using ultrasound biomicroscopy (UBM) and A-scan in eyes with phacomorphic glaucoma (PG) and eyes with mature cataract and to determine differences that may predispose to development of PG.

Methods: Eighty patients (80 eyes) were enrolled in this cross-sectional study. Anterior chamber parameters, namely anterior chamber depth (ACD), angle-opening distance (AOD), iris-lens contact distance (ILCD), and trabecular-ciliary process distance (TCPD), among other parameters, were assessed by UBM (35 MHz), while axial length (AL) and lenticular thickness (LT) were determined by A-scan biometry. Read More

BMC Ophthalmol 2016 Jul 8;16:96. Epub 2016 Jul 8.

Department of Ophthalmology, Istanbul Medipol University, Esenler Hospital, Birlik Mah., Bahceler Cad., Number 5, Esenler, Istanbul, 34230, Turkey.

Background: The SRK/T formula is one of the third generation IOL calculation formulas. The purpose of this study was to evaluate the performance of the SRK/T formula in predicting a target refraction ±1.0D in short and long eyes using ultrasound biometry after phacoemulsification. Read More

Int J Ophthalmol 2016 18;9(6):876-80. Epub 2016 Jun 18.

Department of Ophthalmology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China.

Aim: To compare the axial lengths (ALs) measured with Lenstar, IOLMaster and A-scan contact ultrasound (Ultrasound) in normal and high myopia (HM).

Methods: Eighty-four normal eyes and 49 HM eyes were included. Three consecutive measurements were performed on each eye in the following order: Lenstar, IOLMaster, and Ultrasound. Read More

BMC Ophthalmol 2016 Jun 7;16:78. Epub 2016 Jun 7.

International Centre for Eye Health (ICEH), Department of Clinical Research, London School of Hygiene & Tropical Medicine (LSHTM), Keppel Street, London, WC1E 7HT, UK.

Background: The glaucoma-specific blindness prevalence in Nigeria (0.7 %, 95 % CI 0.6-0. Read More

J Curr Ophthalmol 2015 Sep-Dec;27(3-4):110-4. Epub 2016 Feb 9.

Department of Ophthalmology, University of Ilorin Teaching Hospital, Nigeria.

Purpose: The study compared ocular biometry values using applanation and immersion techniques to determine the most applicable method for our tertiary training centre where personnel with different levels of experience and expertise in biometry take measurements used in calculation of required intraocular lens before cataract surgery.

Methods: The study was a prospective cross-sectional comparative study of different techniques of ocular biometry from diagnostic equipment (biometry probe 10 MHz Sonomed(®) A-scan (PACSCAN 300A, USA). Measurement variables were obtained among children and adults undergoing cataract surgery. Read More

Nat Genet 2016 07 16;48(7):709-17. Epub 2016 May 16.

23andMe, Inc., Mountain View, California, USA.

We performed a scan for genetic variants associated with multiple phenotypes by comparing large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 loci (at a false discovery rate of 10%) associated with multiple traits. Several loci are associated with multiple phenotypes; for example, a nonsynonymous variant in the zinc transporter SLC39A8 influences seven of the traits, including risk of schizophrenia (rs13107325: log-transformed odds ratio (log OR) = 0. Read More

Optom Vis Sci 2016 07;93(7):692-704

*PhD The College of Optometry, University of Houston, Houston, Texas (all authors).

Purpose: Previous ultrasound biomicroscopy (UBM) studies showed that accommodative optical response (AOR) can be predicted from accommodative biometric changes in a young and a pre-presbyopic population from linear relationships between accommodative optical and biometric changes, with a standard deviation of less than 0.55D. Here, paraxial schematic eyes (SE) were constructed from measured accommodative ocular biometry parameters to see if predictions are improved. Read More