3,332 results match your criteria 8-month female

Preconceptional Resveratrol Supplementation Partially Counteracts Age-Related Reproductive Complications in C57BL/6J Female Mice.

Molecules 2021 Mar 30;26(7). Epub 2021 Mar 30.

Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, ul. Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland.

Aging is associated with a drastic decline in fertility/fecundity and with an increased risk of pregnancy complications. Resveratrol (RES), a natural polyphenolic compound, has shown anti-oxidant and anti-inflammatory activities in both human and animal models, thus representing a potential therapeutic and prophylactic anti-aging supplement. Here, we investigated whether preconceptional resveratrol supplementation improved reproductive outcomes in mid-aged (8-month-old) and old (12-month-old) C57BL/6J female mice. Read More

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Impact of estrogen deficiency on diaphragm and leg muscle contractile function in female mdx mice.

PLoS One 2021 31;16(3):e0249472. Epub 2021 Mar 31.

Division of Rehabilitation Science, Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America.

Female carriers of Duchenne muscular dystrophy (DMD) presenting with DMD symptomology similar to males with DMD, such as skeletal muscle weakness and cardiomyopathy, are termed manifesting carriers. There is phenotypic variability among manifesting carriers including the age of onset, which can range from the first to fourth decade of life. In females, estrogen levels typically begin to decline during the fourth decade of life and estrogen deficiency contributes to loss of muscle strength and recovery of strength following injury. Read More

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Long-term fingolimod treatment in two pediatric patients with multiple sclerosis.

Neurol Sci 2021 Mar 10. Epub 2021 Mar 10.

Department of Neurology and Psychiatry, La Sapienza University of Rome, Rome, Italy.

Data suggest that patients with pediatric-onset multiple sclerosis (POMS) should initiate treatment with a disease-modifying therapy early to slow progression. The PARADIGMS trial demonstrated that oral fingolimod reduced the annual rate of relapse by 82% compared with intramuscular interferon beta-1a in children with POMS. The PARADIGMS study had a follow-up of 2 years, but no data are available about the safety and efficacy of fingolimod for longer periods in children with POMS. Read More

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Aerobic, Resistance, and Combination Training on Health-Related Quality of Life: The STRRIDE-AT/RT Randomized Trial.

Front Sports Act Living 2020 11;2:620300. Epub 2021 Feb 11.

Duke University Medical Center, Duke Molecular Physiology Institute, Durham, NC, United States.

The main purpose of this study was to determine the differential effects of aerobic training (AT), resistance training (RT), and a combination of aerobic and resistance training (AT/RT) on changes in self-rated HrQoL measures, including the Short-Form 36 (SF-36) survey and Satisfaction with Physical Function and Appearance survey. We also sought to determine if combination training (AT/RT) has a more or less additive effect compared to AT or RT alone on self-rated HrQoL measures. Participants ( = 137) completed one of three 8-month exercise interventions: (1) AT: 14 kcal exercise expenditure per kg of body weight per week (KKW; equivalent to roughly 12 miles/week) at 65-80% of peak oxygen consumption; (2) RT: 3 days per week, 8 exercises, 3 sets per exercise, 8-12 repetitions per set; (3) AT/RT: full combination of the AT and RT interventions. Read More

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February 2021

Common Peroneal Nerve Palsy Due to Giant Fabella After Total Knee Arthroplasty.

Orthop Surg 2021 Apr 23;13(2):669-672. Epub 2021 Feb 23.

Department of Orthopaedic Surgery, Third Hospital, Hebei Medical University, Shijiazhuang, China.

Background: Common peroneal nerve palsy (CPNP) is a rare but serious complication following primary total knee arthroplasty (TKA). The common peroneal nerve is one of the main molecules of the sciatic nerve. CPNP is a series of symptoms caused by common peroneal nerve injury due to paralysis and atrophy of the fibula and tibia muscles. Read More

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Lorlatinib in pretreated ALK- or ROS1-positive lung cancer and impact of TP53 co-mutations: results from the German early access program.

Ther Adv Med Oncol 2021 9;13:1758835920980558. Epub 2021 Feb 9.

Department Internal Medicine-Oncology, Pius Hospital, Oldenburg, Germany.

Introduction: We report on the results of the German early access program (EAP) with the third-generation ALK- and ROS1-inhibitor lorlatinib.

Patients And Methods: Patients with documented treatment failure of all approved ALK/ROS1-specific therapies or with resistance mutations not covered by approved inhibitors or leptomeningeal carcinomatosis were enrolled and analyzed.

Results: In total, 52 patients were included [median age 57 years (range 32-81), 54% female, 62% never smokers, 98% adenocarcinoma]; 71% and 29% were ALK- and ROS1-positive, respectively. Read More

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February 2021

External carotid artery pseudoaneurysm following upper respiratory infection masquerading as a pharyngeal abscess in an 8-month-old.

Am J Otolaryngol 2021 Feb 16;42(4):102962. Epub 2021 Feb 16.

Department of Otolaryngology-H&N Surgery, Louisiana State University Health-Shreveport, 1501 King's Highway, Shreveport, LA 71130, USA.

Pseudoaneurysms are very rare with an incidence of less than 0.1% in the pediatric population. Approximately 30 cases of carotid artery aneurysms in children have been published in the literature, usually affecting children over one year of age. Read More

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February 2021

Intussusception and SARS-CoV-2 infection.

J Pediatr Surg Case Rep 2021 Apr 11;67:101808. Epub 2021 Feb 11.

Hospital Universitario de Saltillo, Saltillo, Coahuila, Mexico.

We present 2 cases in the same city, of coexistence of intussusception and SARS-CoV-2 infection. The first in an 8 month old male in August 2020 and the second in a 7 month old female in October 2020; both resolved by surgical technique. Although it is known that some intussusception cases. Read More

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Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for advanced non-small cell lung cancer patients with high PD-L1 tumor expression receiving pembrolizumab.

Transl Lung Cancer Res 2021 Jan;10(1):355-367

Department of Mathematics and Statistics, University of Victoria, Victoria, BC, Canada.

Background: We investigated the association of peripheral blood inflammatory markers with overall survival (OS) in pembrolizumab treated advanced non-small cell lung cancer (aNSCLC) patients with programmed death ligand 1 (PD-L1) expression ≥50%. Clinical risk factors for development of immune-related adverse events (irAE) were also explored.

Methods: aNSCLC patients with high PD-L1 expression receiving pembrolizumab monotherapy outside of clinical trials were identified retrospectively. Read More

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January 2021

[Clinical characteristics and genetic analysis of a Chinese pedigree affected with thiamine pyrophosphokinase deficiency].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Feb;38(2):141-144

Department of Pediatrics, Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian 350001, China.

Objective: To investigate the clinical characteristics and genetic variant in a Chinese pedigree affected with thiamine pyrophosphokinase deficiency (TPKD).

Methods: Clinical data of the pedigree were analyzed retrospectively and summarized from the perspectives of clinical manifestation, magnetic resonance imaging (MRI), and genotype. Relevant literature was also reviewed. Read More

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February 2021

A prospective seroepidemiological study of toxocariasis during early childhood in coastal Ecuador: potential for congenital transmission and risk factors for infection.

Parasit Vectors 2021 Feb 5;14(1):95. Epub 2021 Feb 5.

Fundacion Ecuatoriana Para Investigación en Salud, Quinindé, Ecuador.

Background: Although Toxocara spp. infection has a worldwide distribution, to our knowledge, no data from birth cohorts have been reported in published studies on the potential for congenital transmission and determinants of infection in early childhood.

Methods: We followed 290 mother-infant pairs from birth to 5 years of age through periodic collection of data and samples at birth, 7 and 13 months and 2, 3 and 5 years of age. Read More

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February 2021

A longitudinal observational study in two cats naturally-infected with hepadnavirus.

Vet Microbiol 2021 Mar 22;254:108999. Epub 2021 Jan 22.

Department of Veterinary Medicine, University of Bari, Valenzano, Italy. Electronic address:

Hepatitis B virus (HBV) is a major cause of liver disease in humans including chronic hepatitis and hepatocellular carcinoma. Domestic cat hepadnavirus (DCH), a novel HBV-like hepadnavirus, was identified in domestic cats in 2018. From 6. Read More

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Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet.

Biomolecules 2021 Jan 25;11(2). Epub 2021 Jan 25.

Discipline of Nutrition, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand.

BYL719 (alpelisib) is a small molecule inhibitor of PI3K p110α developed for cancer therapy. Targeted suppression of PI3K has led to lifespan extension in rodents and model organisms. If PI3K inhibitors are to be considered as an aging therapeutic, it is important to understand the potential consequences of long-term exposure, and the most practical way to achieve this is through diet administration. Read More

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January 2021

The Impact of Dietary Modifications and Medical Management on 24-Hour Urinary Metabolic Profiles and the Status of Renal Stone Disease in Recurrent Stone Formers.

Isr Med Assoc J 2021 Jan;23(1):12-16

Department of Urology Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Dietary modifications and patient-tailored medical management are significant in controlling renal stone disease. Nevertheless, the literature regarding effectiveness is sparse.

Objectives: To explore the impact of dietary modifications and medical management on 24-hour urinary metabolic profiles (UMP) and renal stone status in recurrent kidney stone formers. Read More

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January 2021

Placental pathology and maternal factors associated with stillbirth: An institutional based case-control study in Northern Tanzania.

PLoS One 2020 31;15(12):e0243455. Epub 2020 Dec 31.

Department of Obstetrics and Gynecology, Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Objective: To determine the placental pathologies and maternal factors associated with stillbirth at Kilimanjaro Christian Medical Centre, a tertiary referral hospital in Northern Tanzania.

Methods: A 1:2 unmatched case-control study was carried out among deliveries over an 8-month period. Stillbirths were a case group and live births were the control group. Read More

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January 2021

Premature ovarian ageing following heterozygous loss of Senataxin.

Mol Hum Reprod 2021 02;27(2)

The Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, The University of Queensland, Herston, QLD, Australia.

Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women. Despite the high prevalence of POA, very little is known regarding its genetic causation. Read More

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February 2021

An Unusual Complication in Plastic Periodontal Surgery.

Case Rep Dent 2020 28;2020:8824246. Epub 2020 Nov 28.

Centro de Investigação Interdisciplinar Egas Moniz, Portugal.

Introduction: Oroantral communications may arise as a result of pathological processes or iatrogenic situations, particularly in oral surgery and implantology, but are uncommon in periodontal plastic surgery. . A healthy 37-year-old female patient with 5 mm Miller Class II recession on the maxillary left second molar was referred for a root coverage procedure. Read More

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November 2020

Recurrent obstructive uropathy secondary to pyometrocolpos in an 8-month-old infant: a case report.

J Med Case Rep 2020 Dec 7;14(1):237. Epub 2020 Dec 7.

Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Background: Pyometrocolpos is accumulation of infected fluid in the uterus and vagina. It is rare in children, mostly seen after menarche as a result of obstructive congenital genital malformation that impairs free drainage of the uterine secretions. In a child, it may present as an acute illness that necessitates urgent and appropriate management and treatment of the underlying cause, which can be a challenge in a resource-limited setting. Read More

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December 2020

[QARS1 gene related glutaminyl-tRNA synthetase deficiency syndrome: report of three cases and a review of literature].

Zhonghua Er Ke Za Zhi 2020 Dec;58(12):1006-1012

Department of Pediatrics, the Fujian Medical University Affiliated Fuzhou Children Hospital, Fuzhou 350001, China.

To investigate the clinical characteristics, treatment and prognosis of QARS1 gene related glutaminyl-tRNA synthetase deficiency. To summarize and analyze the clinical manifestations, imaging, laboratory examination, genetic variant characteristics and treatment of three patients from the Fujian Medical University Affiliated Union Hospital, the 900th Hospital of People's Liberation Army, the First Medical Center of People's Liberation Army General Hsopital carrying compound heterozygous variations in QARS1 gene with a long-term follow-up in China. A literature search was conducted using Wanfang, Weipu, China National Knowledge Infrastructure (CNKI) and Pubmed databases with the keywords "QARS", "QARS1" and "glutaminyl-tRNA Synthetase"(up to December 2019). Read More

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December 2020

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease.

Neurobiol Dis 2021 01 24;148:105198. Epub 2020 Nov 24.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools. Perturbations of astrocyte glutamine synthesis have been described in AD, but whether this functionally affects neuronal neurotransmitter synthesis is not known. Read More

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January 2021

Where the congenital heart disease meets the pulmonary arterial hypertension, FLNA matters: a case report and literature review.

BMC Pediatr 2020 11 3;20(1):504. Epub 2020 Nov 3.

Congenital Heart Disease center, Wuhan Asia Heart hospital, 753 Jinghan Ave, 430022, Wuhan, China.

Background: Pediatric patients with genetic disorders have a higher incidence of pulmonary arterial hypertension (PAH) regardless of their heart defects. Filamin A (FLNA) mutation is recently recognized to be associated with pediatric pulmonary disorders, however, the clinical courses of PAH related to the mutation were reported in limited cases. Here, we presented a case and pooled data for better understanding of the correlation between FLNA mutation and pediatric PAH. Read More

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November 2020

Examining the pace of change in contraceptive practices in abortion services - a follow-up case study of a quality improvement collaborative.

BMC Health Serv Res 2020 Oct 16;20(1):948. Epub 2020 Oct 16.

Jönköping Academy for Improvement of Health and Welfare, School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Background: Among all women who experienced an abortion in Sweden 2017, 45% had previously underwent at least one abortion. This phenomenon of increasing rates of repeat abortions stimulated efforts to improve contraceptive services through a Quality Improvement Collaborative (QIC) with user involvement. The participating teams had difficulty in coordinating access post-abortion to the most effective contraception, Long-acting reversible contraception (LARC), during the eight-month QIC. Read More

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October 2020

Steroid-responsive neutropenia in a cat with progressive feline leukemia virus infection.

Vet Clin Pathol 2020 Sep 16;49(3):389-393. Epub 2020 Oct 16.

Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece.

An 8-month-old female domestic shorthair cat was presented to the Animal Medical Center with anorexia, lethargy, and mild gastrointestinal signs. A CBC revealed a profound neutropenia, and serologic testing with an in-house test kit (SNAP FIV/FeLV Combo, IDEXX) was positive for feline leukemia virus (FeLV) antigen. Serial hematologic examinations during hospitalization showed a persistent neutropenia with occasionally severe anemia and thrombocytopenia. Read More

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September 2020

Treatment of friendship problems in children with attention-deficit/hyperactivity disorder: Initial results from a randomized clinical trial.

J Consult Clin Psychol 2020 Oct;88(10):871-885

Clinique d'apprentissage spécialisée.

Objective: This study evaluated a novel intervention for friendship problems in children with attention-deficit/hyperactivity disorder (ADHD). Parental Friendship Coaching (PFC) teaches parents to coach their children in targeted friendship behaviors that are lacking in children with ADHD and that help children develop good quality friendships.

Method: Participants were 172 families of children with ADHD and social impairment (ages 6-11; 29. Read More

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October 2020

Expanding phenotypic and mutational spectra of mitochondrial HMG-CoA synthase deficiency.

Eur J Med Genet 2020 Dec 9;63(12):104086. Epub 2020 Oct 9.

Center of Excellence for Medical Genomics, Medical Genomics Cluster, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Excellence Center for Genomics and Precision Medicine, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, 10330, Thailand.

Mitochondrial 3-hydroxy-3 methylglutaryl-CoA synthase-2 deficiency (HMGCS2D) is a rare autosomal recessive inborn error of hepatic ketogenesis, caused by mutations in HMGCS2. As its clinical and laboratory manifestations resemble many other metabolic disorders, HMGCS2D definite diagnosis presents a challenge, frequently requiring molecular tests. Only 26 patients with HMGCS2 mutations have been previously described, and this study reports the first two unrelated Thai patients, a 9-month-old male and an 8-month-old female, with HMGCS2D. Read More

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December 2020

Successful endovascular treatment of pediatric basilar infectious (mycotic) aneurysm: a case report and review of the literature.

Childs Nerv Syst 2020 Oct 8. Epub 2020 Oct 8.

Department of Radiology, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.

Background: Intracranial infectious aneurysms are rarely reported in children; in particular, they are very rare in infants. They are mostly related to infective endocarditis and are usually located in the anterior cerebral vasculature. A ruptured intracranial infectious aneurysm is a catastrophic event associated with high morbidity and mortality rates. Read More

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October 2020

Polycystic kidney disease concurrent with feline parvovirus and bacterial infections in domestic shorthair cat: a case report.

Comp Clin Path 2020 Sep 28:1-5. Epub 2020 Sep 28.

Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan Malaysia.

Feline polycystic kidney disease (PKD) is an inherited disorder caused by the mutation of PKD1 gene that eventually lead to the development of chronic kidney disease. The latter condition causes hypertension and eventually progress into congestive heart failure. Feline parvovirus (FPV) is a highly contagious and often fatal disease infecting cats and other members of Felidae. Read More

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September 2020

Characterizing the effects of tonic 17β-estradiol administration on spatial learning and memory in the follicle-deplete middle-aged female rat.

Horm Behav 2020 11 25;126:104854. Epub 2020 Sep 25.

Department of Psychology, Arizona State University, Tempe, AZ 85287, United States of America; Arizona Alzheimer's Consortium, Phoenix, AZ 85006, United States of America. Electronic address:

17β-estradiol (E2)-containing hormone therapy is a safe, effective way to alleviate unwanted menopause symptoms. Preclinical research has focused upon the role of E2 in learning and memory using a surgically menopausal rodent model whereby the ovaries are removed. Given that most women retain their reproductive tract and undergo a natural menopause transition, it is necessary to understand how exogenous E2 impacts a structurally intact, but follicle-deplete, system. Read More

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November 2020

Variable infant care contributions in cooperatively breeding groups of wild saddleback tamarins.

Am J Primatol 2020 12 18;82(12):e23190. Epub 2020 Sep 18.

Department of Anthropology, Northern Illinois University, DeKalb, Illinois, USA.

Among non-human primates, alloparental infant care is most extensive in callitrichines, and is thought to be particularly costly for tamarins whose helpers may suffer increased energy expenditure, weight loss, and reduced feeding time and mobility. The costs and benefits of infant care likely vary among group members yet very few wild studies have investigated variable infant care contributions. We studied infant care over an 8-month period in four wild groups of saddleback tamarins in Bolivia to evaluate: (a) what forms of infant care are provided, by whom, and when, (b) how individuals adjust their behavior (activity, vigilance, height) while caring for infants, and (c) whether individuals differ in their infant care contributions. Read More

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December 2020

Low-vitamin-D diet lowers cerebral serotonin concentration in mature female mice.

Nutr Res 2020 09 24;81:71-80. Epub 2020 Jul 24.

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA; Department of Medicine, Rutgers-RWJ Medical School, New Brunswick, NJ. Electronic address:

Low circulating 25-hydroxyvitamin D (25OHD) is commonly found in obese individuals and is often attributed to a volume dilution effect of adipose tissue. However, low vitamin D (LD) intake may contribute to the obesity itself. In this study, we examine whether low vitamin D status contributes to increased food intake and weight gain and can be explained by altered brain serotonin metabolism in 8-month-old female C57BL/6J mice. Read More

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September 2020