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[Effects of treatment based on different target mean arterial pressure on gastrointestinal function in septic shock patients with hypertension].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):517-522

Department of Critical Care Medicine, Liuzhou People's Hospital, Liuzhou 545006, Guangxi Zhuang Autonomous Region, China. Corresponding author: Zhu Xiaowen, Email:

Objective: To investigate the effect of fluid resuscitation and circulatory support, directed by different target mean arterial pressure (MAP), on abdominal blood flow, gastrointestinal function and inflammatory response in septic shock patients with hypertension.

Methods: A prospective randomized controlled study was conducted. Hypertensive patients with septic shock admitted to the department of intensive care unit (ICU) of Liuzhou People's Hospital from January 1, 2019 to May 31, 2020 were enrolled. Read More

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Yersinia pseudotuberculosis Infection Accompanied by Intussusception and Incomplete Kawasaki Disease in a 7-year-old Girl.

Keio J Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Pediatrics, National Hospital Organization Saitama Hospital, Saitama, Japan.

Infection with Yersinia pseudotuberculosis, a known causal pathogen of human bacterial gastroenteritis, causes various symptoms and complications. A previously healthy 7-year-old girl was admitted because of fever and gastrointestinal symptoms. She was initially diagnosed with intussusception by abdominal ultrasonography. Read More

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Long-term monitoring of chronic demyelination and remyelination in a rat ischemic stroke model using macromolecular proton fraction mapping.

J Cereb Blood Flow Metab 2021 Jun 9:271678X211020860. Epub 2021 Jun 9.

Laboratory of Neurobiology, Tomsk State University, Tomsk, Russian Federation.

Remyelination is a key process enabling post-stroke brain tissue recovery and plasticity. This study aimed to explore the feasibility of demyelination and remyelination monitoring in experimental stroke from the acute to chronic stage using an emerging myelin imaging biomarker, macromolecular proton fraction (MPF). After stroke induction by transient middle cerebral artery occlusion, rats underwent repeated MRI examinations during 85 days after surgery with histological endpoints for the animal subgroups on the 7th, 21st, 56th, and 85th days. Read More

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The measurement of wound tensile strength and the effect of PRP on wound tensile force: an experimental investigation on rabbits.

J Plast Surg Hand Surg 2021 Jun 9:1-9. Epub 2021 Jun 9.

Department of Plastic, Reconstructive and Aesthetic Surgery, Abant Izzet Baysal University, Bolu, Turkey.

Platelets in PRP are used for their functions in the initiation and regulation of the wound healing process and are used for the repair of injured tissues and the rejuvenation of healthy tissues. In this study, we evaluated the effect of a single dose platelet-rich plasma on skin wound healing and we demonstrated the effect of platelet-rich plasma on skin wound healing by measuring changes in the wound tensile strength. A total of 8 incisions, each 3 cm long, were made on the back skin on both sides of the vertebral column of 12 rabbits. Read More

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Endoscopic coblation treatment for congenital pyriform sinus fistula in children.

Medicine (Baltimore) 2021 May;100(19):e25942

Department of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Abstract: Congenital pyriform sinus fistula (CPSF) is a very rare branchial apparatus malformation. Traditional open surgery for fistulectomy might fail to excise the lesion completely, leading to continual recurrence. Herein, we report our experience of endoscopic coblation technique for treatment of CPSF in children. Read More

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Mediodorsal thalamus lesion increases paradoxical sleep in rats.

Sleep Sci 2021 Jan-Mar;14(1):33-38

All India Institute of Medical Sciences, Department of Physiology - New Delhi - Delhi - India.

Introduction: The mediodorsal thalamic nucleus has extensive connections with prefrontal cortex, which is considered as seat of cognition. It also receives connections from sleep-wakefulness regulating areas in the brainstem and hypothalamus. Decreased volume and degeneration of mediodorsal thalamic nuclei have been reported in schizophrenia and fatal familial insomnia, respectively. Read More

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Salvage surgery after definitive chemoradiotherapy through VATS for an initial unresectable locally advanced lung cancer: an alternative consolidative modality to radiotherapy?

Surg Case Rep 2021 Jun 8;7(1):138. Epub 2021 Jun 8.

Division of Thoracic Oncology, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Definitive chemoradiotherapy (dCRT) is the first choice treatment for patients with locally advanced non-small cell lung cancer (NSCLC), but up to 35% of dCRT-treated tumors may have persistent or recurrent disease. Since the last decades, multimodality therapy showing potential for cure has become the mainstream for treatment of locally advanced NSCLCs, even some that were initially inoperable. Although salvage lung resection after dCRT has been reported with acceptable survivals, experiences in this respect are still limited. Read More

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Ultrasonographic assessment of change in omasal position during the last month of gestation and first month of lactation in buffaloes.

Schweiz Arch Tierheilkd 2021 Jun;163(6):411-418

Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.

Introduction: This study was aimed to determine the effect of advanced pregnancy on the topography and size of the omasum in 22 healthy Murrah buffaloes. The omasum was scanned 15-20 days before and after parturition, as per the standard procedure. The dorsal and ventral margins of the omasum were identified and marked at each intercostal space (ICS). Read More

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Fast antibody responses by immuno-targeting and nanotechnology strategies versus HBsAg vaccine.

Iran J Basic Med Sci 2021 Apr;24(4):545-550

Recombinant Vaccine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Though immunization with HBsAg has been routine since the 1980s, it has numerous limitations such as low or none humoral immune responses. Today, nanotechnology is used in vaccinology to achieve higher potency. The present study deals with the achievement of fast antibody response of humoral immune responses using immune-targeting through mannosylated nanocarriers of the vaccine. Read More

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Retracing Schwann Cell Developmental Transitions in Embryonic Dissociated DRG/Schwann Cell Cocultures in Mice.

Front Cell Neurosci 2021 20;15:590537. Epub 2021 May 20.

INSERM UMRS 1124, Faculty of Basic and Biomedical Sciences, Université de Paris, Paris, France.

Embryonic Dissociated Dorsal Root Ganglia (DRG) cultures are often used to investigate the role of novel molecular pathways or drugs in Schwann cell development and myelination. These cultures largely recapitulate the order of cellular and molecular events that occur in Schwann cells of embryonic nerves. However, the timing of Schwann cell developmental transitions, notably the transition from Schwann Cell Precursors (SCP) to immature Schwann cells (iSC) and then to myelinating Schwann cells, has not been estimated so far in this culture system. Read More

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Evaluation of heat shock protein 70 and toll-like receptor 4 expression in gingival crevicular fluid in response to orthodontic forces.

Clin Oral Investig 2021 Jun 6. Epub 2021 Jun 6.

Department of Orthodontics, Faculty of Dentistry, Gazi University, 8 Cd. 82.Sk. No 4 Emek, Ankara, Turkey.

Objectives: The aim of this study was to assess the concentrations of heat shock protein 70 (HSP70) and toll-like receptor 4 (TLR4) during orthodontic tooth movement and to compare their levels with interleukin-1β (IL-1β), a well-known proinflammatory biomarker.

Materials And Methods: This study consisted of 20 patients (8 males, 12 females; mean age 14.75 ± 2. Read More

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Study of the effect of added bronchoscopic suction to routine treatment of ventilator associated pneumonia patients in surgical ICU.

J Pak Med Assoc 2021 May;71(5):1326-1331

Department of Anesthesiology, Birjand University of Medical Sciences, Iran.

Objective: Comparing BAL and antibiotic therapy with antibiotic therapy itself for treating VAP patients in ICU.

Methods: In this randomized clinical trial, the first group was treated using antibiotics and closed-suction was performed daily, using 50 cc of sterile normal saline. The second group was treated with antibiotics and daily closed-suction with 50 cc of sterile normal saline, plus bronchoscopic suction every other day. Read More

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Influence of maintaining apical patency in post-endodontic pain.

BMC Oral Health 2021 Jun 2;21(1):284. Epub 2021 Jun 2.

Department of Orthodontics and Dentofacial Orthopaedics, Universal College of Medical Sciences, Ranigaon, Bhairahawa, Nepal.

Background: The concept of instrumentation beyond the apical foramen by small flexible file to prevent apical blockage is apical patency. However, this procedure might endow postoperative pain, thus to maintain apical patency or not is the matter of dilemma. Hence, the primary objective of this study was to compare postoperative pain between apical patency and non-patency groups and secondary objective was to evaluate the influence of number of visits, vitality of teeth, group of teeth and preoperative pain on post-operative pain. Read More

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The Effect of MMP-1 on Wound Healing and Scar Formation.

Aesthetic Plast Surg 2021 Jun 1. Epub 2021 Jun 1.

Istanbul University-Cerrahpaşa Cerrahpaşa Medical School ENT Department, Istanbul, Turkey.

Background: In this study, we investigated the effect of matrix metalloproteinase-1 (MMP-1) on wound healing on skin in a model produced in rats.

Methods: Sixteen Sprague-Dawley male rats were included in the study. The four full-thickness skin wound was created on the dorsal area of each rat with 4. Read More

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A Histological and Morphometric Assessment of the Adult and Juvenile Rat Livers after Mild Traumatic Brain Injury.

Cells 2021 May 6;10(5). Epub 2021 May 6.

Department of Family Medicine and Community Nursing, Medical University of Lublin, PL-20-081 Lublin, Poland.

Traumatic brain injury (TBI) is one of the most severe problems of modern medicine that plays a dominant role in morbidity and mortality in economically developed countries. Our experimental study aimed to evaluate the histological and morphological changes occurring in the liver of adult and juvenile mildly traumatized rats (mTBI) in a time-dependent model. The experiment was performed on 70 adult white rats at three months of age and 70 juvenile rats aged 20 days. Read More

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The influence of Javanese turmeric () on the pharmacokinetics of warfarin in rats with single and multiple-dose studies.

Pharm Biol 2021 Dec;59(1):639-646

Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, Gunma University, Maebashi, Japan.

Context: Co-administration between warfarin (WF) and Roxb. (Zingiberaceae) (CX) is found in Indonesian patients and need to be evaluated.

Objective: This study assesses the effect of concomitant administration of CX extract on the pharmacokinetics of WF in rats. Read More

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December 2021

Ectopic pregnancy: a single-center experience over ten years.

Reprod Biol Endocrinol 2021 Jun 1;19(1):79. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenbergische Stiftung, Nibelungenallee 37-41, D-60318, Frankfurt am Main, Hessen, Germany.

Purpose: The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality.

Methods: This was a retrospective analysis of pregnancy-related records from a tertiary center over a period of ten years. Data on age, gravidity, parity, EP risk, amenorrhea duration, abdominal pain presence and location, β-human chorionic gonadotropin (β-HCG) level, ultrasound findings, therapeutic intervention, exact EP implantation site and length of hospital stay (LOS) were obtained from the database. Read More

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Effects of different implant surface properties on the biological behavior of Schwann cells.

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Jun;39(3):279-285

Dept. of Implantation, Tianjin Stomatological Hospital (Hospital of Stomatology, Nankai University), Tianjin 300041, China.

Objectives: This study investigated the effects of different implant surface properties on the biological behavior of Schwann cells.

Methods: Schwann cells (SCs) were cultured on three types of implant surfaces including smooth polished (SMO), sand-blasted, large grit, acid-etched (SLA), and chemically-modified SLA (modSLA). At different time points, the morphology and adhesion of SCs on the implant surfaces were observed by scanning electron microscope. Read More

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Analysis of decomposition in 23 seafood products by liquid chromatography with high-resolution mass spectrometry with sensory-driven modeling.

Food Sci Nutr 2021 May 11;9(5):2658-2667. Epub 2021 Mar 11.

Pacific Northwest Laboratory Office of Regulatory Affairs U.S. Food and Drug Administration Bothell WA USA.

Samples of 23 seafood products were obtained internationally in processing plants and subjected to controlled decomposition to produce seven discrete quality increments. A sensory expert evaluated each sample for decomposition, using a scale of 1-100. Samples were then extracted and analyzed by liquid chromatography with high-resolution mass spectrometry (LC-HRMS). Read More

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Efficiency of dihydroxamic and trihydroxamic siderochelates to extract uranium and plutonium from contaminated soils.

J Environ Radioact 2021 Sep 18;235-236:106645. Epub 2021 May 18.

Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR 6302, CNRS, Université Bourgogne-Franche-Comté, 9 avenue Alain Savary, BP 47870, 21078, Dijon Cedex, France. Electronic address:

Actinide-based mineral phases occurring in contaminated soils can be solubilized by organic chelators excreted by plants, such as citrate. Herein, the efficiency of citrate towards U and Pu extraction is compared to that of siderophores, whose primary function is the acquisition of iron(III) as an essential nutrient and growth factor for many soil microorganisms. To that end, we selected desferrioxamine B (DFB) as an emblematic bacterial trishydroxamic siderophore and a synthetic analog, abbreviated (L)H, of the tetradentate rhodotorulic acid (RA) produced by yeasts. Read More

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September 2021

Research and application of KABP nursing model in cardiac rehabilitation of patients with acute myocardial infarction after PCI.

Am J Transl Res 2021 15;13(4):3022-3033. Epub 2021 Apr 15.

Department of Radiology, Brain Hospital of Weifang People's Hospital Weifang, Shandong Province, China.

Objective: To investigate the effect of a nursing protocol based on the KABP (Knowledge, Attitude, Belief and Practice) model in the cardiac rehabilitation (CR) of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).

Methods: In this prospective study, a total of 76 patients with AMI who underwent PCI were selected as the research objects. Through random number table, the participants were divided into 41 cases in the KABP group (cardiac rehabilitation nursing based on KABP model) and 35 cases in the control group (conventional rehabilitation nursing). Read More

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Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial.

Lancet Oncol 2021 06 18;22(6):824-835. Epub 2021 May 18.

Department of Radiation Oncology, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY, USA.

Background: Previous phase 2 trials of neoadjuvant anti-PD-1 or anti-PD-L1 monotherapy in patients with early-stage non-small-cell lung cancer have reported major pathological response rates in the range of 15-45%. Evidence suggests that stereotactic body radiotherapy might be a potent immunomodulator in advanced non-small-cell lung cancer (NSCLC). In this trial, we aimed to evaluate the use of stereotactic body radiotherapy in patients with early-stage NSCLC as an immunomodulator to enhance the anti-tumour immune response associated with the anti-PD-L1 antibody durvalumab. Read More

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Alleviation of cisplatin-induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase-3 activity.

Pharmacol Res Perspect 2021 May;9(3):e00788

Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Aims: Cisplatin (CP), as an effective alkylating agent, is widely used in cancer treatment, while hepatotoxicity is one of its side effects. Gliclazide (GLZ), as an oral hypoglycemic drug, has antioxidant and anti-inflammatory properties. This study was designed to investigate the protective effect of GLZ against CP-induced hepatotoxicity in mice. Read More

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A population-based prospective study on rest-activity rhythm and mild cognitive impairment among Hong Kong healthy community-dwelling older adults.

Neurobiol Sleep Circadian Rhythms 2021 May 16;10:100065. Epub 2021 Apr 16.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.

Background: Relatively few studies investigated the association between rest-activity circadian rhythm and cognitive impairment in population-based study, and the evidence from Asian populations is sparse. We aimed to examine the relationship of actigraphy measured rest-activity circadian rhythm with mild cognitive impairment (MCI) or cognitive impairment in Hong Kong healthy community-dwelling older adults.

Methods: We recruited 174 Hong Kong healthy adults aged ≥65 years (36 male vs. Read More

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The effect of Wnt/β-catenin pathway on the scleral remolding in the mouse during form deprivation.

Int Ophthalmol 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Many reports have shown that Wnt/β-Catenin pathway is associated with a variety of diseases, but its role in the pathogenesis of myopia is still unknown. In order to clarify the role of Wnt/β-catenin pathway in the development of form deprivation myopia (FDM), this study investigated the expression of scleral Wls, β-catenin and TCF4 in mice model of form deprivation (FD) myopia.

Methods: Three parallel experimental groups, including FD, monocular exposure (SC) and binocular exposure (NC) group, were designed to investigate the effects of Wnt/β-Catenin pathway on scleral remodeling mouse during form deprivation in three-week-old C57BL/6 mice. Read More

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Effect of finishing and polishing systems on the surface roughness and color change of composite resins.

J Clin Exp Dent 2021 May 1;13(5):e446-e454. Epub 2021 May 1.

Istanbul University, Faculty of Dentistry, Department of Restorative Dental Treatment, Istanbul, Turkey.

Background: This study is to examine the surface roughness and color changes occurring on composite resins following the application of different finishing and polishing systems.

Material And Methods: In our study, a total of 200 samples were prepared from composites resin (6×2 mm) containing supra-nano, submicron hybrid, nanohybrid, nano-ceramic and microhybrid filler. They were polished with diamond, aluminum oxide, silicon carbide finishing and polishing systems. Read More

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Pouteria ramiflora leaf extract on emulgel in wound healing activity in diabetic rats.

Braz J Biol 2021 10;82:e239378. Epub 2021 May 10.

Universidade Anhanguera - UNIDERP, Programa de Pós Graduação em Meio Ambiente e Desenvolvimento, Campo Grande, MS, Brasil.

The genus Pouteria has been studied because it presents various activities, among which is its anti-inflammatory potential. The effects of Pouteria ramiflora Carbopol gel on the healing of skin wounds in diabetic rats were evaluated by microscopic imaging. Streptozotocin was administered intraperitoneally in animals that had fasted for 12 hours, a situation confirmed by the glycemic index (˃ 240 mg dL-1). Read More

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Clinical efficacy evaluation and prevention of adverse reactions in a randomized trial of a combination of three drugs in the treatment of cancerous pudendal neuralgia.

Ann Palliat Med 2021 May 6;10(5):5754-5762. Epub 2021 May 6.

Medical College, Yanbian University, Yanji, China; Laboratory of Molecular Virology and Immunology, Institute of Military Veterinary Medicine, Academy of Military Medical Science, Changchun, China.

Background: To explore the clinical efficacy, safety, and prevention of major adverse reactions of the non-steroidal anti-inflammatory drug celecoxib combined with OxyContin and Pregabalin in the treatment of cancerous pudendal neuralgia.

Methods: A total of 51 patients presenting with pelvic malignancies with cancerous pudendal neuralgia were selected, and random number table method was used to allocate them to either the experimental group (n=27) or control group (n=24). The control group was treated with OxyContin combined with Pregabalin, and the experimental group was treated with Celecoxib on the basis of the control group. Read More

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Effects of nasal packing and transseptal suturing on swallowing after septoplasty.

Eur Arch Otorhinolaryngol 2021 May 10. Epub 2021 May 10.

Otorhinolaryngology Department, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Purpose: This clinical trial aimed to investigate the effects of different nasal packing methods and transseptal suture technique on swallowing after septoplasty.

Methods: This randomized prospective study consists of 180 consecutive patients with septal deviation. All the patients underwent septoplasty. Read More

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Integrated analysis of long noncoding RNAs and mRNA expression profiles reveals the potential role of lncRNAs in early stage of post-peripheral nerve injury in Sprague-Dawley rats.

Aging (Albany NY) 2021 05 8;13(10):13909-13925. Epub 2021 May 8.

Department of Orthopedics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

The regulatory role of lncRNAs in the early stage post peripheral nerve injury (PNI) is not yet clear. In this study, next-generation sequencing was used to perform deep sequencing on normal sciatic nerves (control) and lesional tissues derived on the 4th (D4) and 7th days (D7) after sciatic nerve injury in rats. Time-point unique differentially expressed lncRNAs (DElncRNAs) were analyzed for functional enrichment. Read More

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