2,355 results match your criteria 772 total


Multi-modal Machine Learning using Visual Fields and Peripapillary Circular OCT Scans in Detection of Glaucomatous Optic Neuropathy.

Ophthalmology 2021 Jul 30. Epub 2021 Jul 30.

Singapore Eye Research Institute, Singapore National Eye Center, and Duke-NUS Medical School, Singapore.

Purpose: To develop and test a multi-modal artificial intelligence (AI) algorithm, FusionNet, using the pattern deviation probability plots (PDPs) from visual field (VF) reports and circular peripapillary optical coherence tomography (OCT) to detect glaucomatous optic neuropathy (GON).

Design: Cross-sectional study.

Subjects: A total of 2463 pairs of VF and OCT images from 1083 patients. Read More

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Chromosome-scale genome assembly of sweet cherry (Prunus avium L.) cv. Tieton obtained using long-read and Hi-C sequencing.

Hortic Res 2020 Aug 1;7(1):122. Epub 2020 Aug 1.

Shandong Key Laboratory of Fruit Biotechnology Breeding, Shandong Institute of Pomology, Taian, Shandong, 271000, China.

Sweet cherry (Prunus avium) is an economically significant fruit species in the genus Prunus. However, in contrast to other important fruit trees in this genus, only one draft genome assembly is available for sweet cherry, which was assembled using only Illumina short-read sequences. The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies. Read More

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Long-term costs and cost-effectiveness of adjunctive corticosteroids for patients with septic shock in New Zealand.

Aust Crit Care 2021 Jul 26. Epub 2021 Jul 26.

The George Institute for Global Health, Sydney, Australia; University of New South Wales, Sydney, Australia. Electronic address:

Objective: The aim of the study was to determine whether adjunctive hydrocortisone reduced healthcare expenditure and was cost-effective compared with placebo in New Zealand patients in the Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL) trial.

Design: This is a health economic analysis using data linkage to New Zealand Ministry of Health databases to determine resource use, costs, and cost-effectiveness for a 24-month period.

Setting: The study was conducted in New Zealand. Read More

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Insomnia episodes, new-onset pharmacological treatments and other sleep disturbances during the COVID-19 pandemic: a nationwide cross-sectional study in Brazilian health care professionals.

J Clin Sleep Med 2021 Jul 27. Epub 2021 Jul 27.

Laboratório do Sono, LIM 63, Pulmonary Division, Heart Institute (InCor), Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Study Objectives: To evaluate the impact of COVID-19 pandemic on insomnia and other sleep disturbances in health care professionals.

Methods: A survey was distributed using social media and organizational emails to Brazilian active health care professionals during the COVID-19 outbreak. We explored potential associated factors including age, gender, occupation, workplace, work hours, income, previous infection with COVID-19, recent/current contact with COVID-19 patients, regional number of incident deaths, anxiety, and burnout. Read More

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Development of Machine Learning Models for Prediction of Osteoporosis from Clinical Health Examination Data.

Int J Environ Res Public Health 2021 07 18;18(14). Epub 2021 Jul 18.

Department of Family Medicine, Mackay Memorial Hospital, Taipei City 10491, Taiwan.

Osteoporosis is treatable but often overlooked in clinical practice. We aimed to construct prediction models with machine learning algorithms to serve as screening tools for osteoporosis in adults over fifty years old. Additionally, we also compared the performance of newly developed models with traditional prediction models. Read More

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Reliability of information on YouTube™ regarding pediatric dental trauma.

Dent Traumatol 2021 Jul 21. Epub 2021 Jul 21.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adıyaman University, Adıyaman, Turkey.

Background/aim: Traumatic dental injuries are a common health problem in children. The aim of this study was to evaluate the quality of the video contents on YouTube™ regarding traumatic dental injuries in children taking into account the information of IADT, and to analyze whether it is useful for patients and dentists.

Material And Methods: A search was performed on YouTube™ using the search term "trauma in pediatric dentistry" with the default filter set to "sort by relevance". Read More

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Development and Validation of a Risk Prediction Model for Ventricular Arrhythmia in Elderly Patients with Coronary Heart Disease.

Cardiol Res Pract 2021 2;2021:2283018. Epub 2021 Jul 2.

Department of Cardiology, First Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Sudden cardiac death is a leading cause of death from coronary heart disease (CHD). The risk of sudden cardiac death (SCD) increases with age, and sudden arrhythmic death remains a major cause of mortality in elderly individuals, especially ventricular arrhythmias (VA). We developed a risk prediction model by combining ECG and other clinical noninvasive indexes including biomarkers and echocardiology for VA in elderly patients with CHD. Read More

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Evaluation on Long-Term Test-Retest Reliability of the Short-Form Childhood Trauma Questionnaire in Patients with Schizophrenia.

Psychol Res Behav Manag 2021 13;14:1033-1040. Epub 2021 Jul 13.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Background: Many studies have reported an association between childhood trauma exposure and schizophrenia. Among these studies, the Short-form Childhood Trauma Questionnaire (CTQ-SF) is one of the most widely used measures of childhood trauma. However, little is known regarding the long-term reliability of the CTQ-SF, especially in patients with psychopathology. Read More

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Characteristics of Fall-Related Fractures in Older Adults with Cerebrovascular Disease: A Cross-Sectional Study.

Clin Interv Aging 2021 13;16:1337-1346. Epub 2021 Jul 13.

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People's Republic of China.

Purpose: Limited information exists on fall-related fractures in older adults with cerebrovascular disease. This study aimed to determine the characteristics of older adults with cerebrovascular disease who sustained fall-related fractures and identify the associated risk factors for perioperative complications.

Patients And Methods: This was a cross-sectional study, which included patients with cerebrovascular disease who sustained fractures between Jan. Read More

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A comparative study of single Theileria lestoquardi and mixed infections with Theileria ovis.

Parasit Vectors 2021 Jul 20;14(1):370. Epub 2021 Jul 20.

Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, AlKhoud 123, PO Box 35, Muscat, Oman.

Background: Epidemiological surveys in Oman have revealed a high prevalence of the co-occurrence of the pathogenic Theileria lestoquardi and the non-pathogenic Theileria ovis among sheep in the Barka region, Oman. Our most recent data illustrated an interaction and reduced mortality risk in animals co-infected with T. lestoquardi and T. Read More

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[Value of ATP synthase C subunit in predicting cardiac function and outcomes of sepsis].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(27):2140-2146

Emergency Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

To investigate the value of serum mitochondrial ATP synthase C subunit level in the evaluation of cardiac functional status and prognosis in patients with sepsis. A total of 165 sepsis patients admitted to the Emergency Intensive Care Unit (EICU) of the First Affiliated Hospital of Wenzhou Medical University from January 1, 2017 to December 31, 2018 were included, there were 103 males (62.4%) and 62 females (37. Read More

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Pharmacy Customers' Experiences of Use, Usability, and Satisfaction of a Nationwide Patient Portal: Survey Study.

J Med Internet Res 2021 Jul 16;23(7):e25368. Epub 2021 Jul 16.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Background: Patient portals have been introduced in several countries in the last few decades. Despite worldwide objectives of introducing patient portals, nationwide portals are rare, and studies about their use are limited. Finland is one of the forerunners in developing nationwide health data systems. Read More

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Analysis of gender-specific associations between aldehyde dehydrogenase 2 () rs671 genetic polymorphisms and serum uric acid levels in Han Chinese.

Ann Transl Med 2021 May;9(9):772

Department of Health Care, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.

Background: Serum uric acid (SUA) is influenced by lifestyle and genetics, and unbalanced SUA levels are linked to various common disorders. While the aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism appears to be associated with SUA levels, the evidence remains inconclusive. The aim of this study was to examine the distribution of the ALDH2 rs671 polymorphism among Han Chinese in Beijing and determine the association between this polymorphism and SUA. Read More

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[Epidemiological investigation of allergic rhinitis in central cities and countrysides of Inner Mongolia region].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;56(6):635-642

Department of Otorhinolaryngology, Inner Mongolia People's Hospital, Hohhot 010010, Inner Mongolia Autonomous Region, China.

To investigate the prevalence of allergic rhinitis (AR) in 3 central cities (Chifeng, Hohhot, Ordos) and the surrounding rural areas of Inner Mongolia region, and to look for possible risk factors related to the disease. From March to October of 2019, a multi-stage stratified random sampling epidemiological survey was conducted in Chifeng, Hohhot, Ordos and rural areas. The AR-related factors of the population were obtained in the form of face-to-face questionnaire survey, and the skin prick test (SPT) was taken for the participants. Read More

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[Diagnostic value of FNDC5 in patients with subclinical diabetic cardiomyopathy].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jul 24;49(7):687-693. Epub 2021 Jul 24.

Department of Endocrinology, Third Affiliated Hospital of Soochow University, Suzhou 213000, China.

To estimate the diagnostic value of fibronectin type Ⅲ-domain containing protein 5 (FNDC5) in subclinical diabetic cardiomyopathy. A total of 94 patients with type 2 diabetes (T2DM), who were hospitalized from April 2018 to June 2019 in the Third Affiliated Hospital of Soochow University, were enrolled in this study. Patients were divided into T2DM with cardiac dysfunction (subclinical DCM) group (=47) and T2DM without cardiac dysfunction (non-DCM) group (=47) according to echocardiography and gated myocardial perfusion imaging results. Read More

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An audit of the British Thoracic Society asthma discharge care bundle in a teaching hospital.

Br J Nurs 2021 Jul;30(13):772-779

Senior Lecturer, School of Healthcare and Social Work, Buckinghamshire New University, Uxbridge.

Background: The UK asthma mortality rate has risen by 33% over a decade. The national enquiry into 195 asthma-related deaths revealed that most of these deaths were preventable. The Asthma Discharge Care Bundle (ADCB) is recommended for use when discharging patients with an acute asthma attack and/or exacerbation. Read More

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Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.

J Formos Med Assoc 2021 Jul 6. Epub 2021 Jul 6.

Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Neurology, Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address:

Background/purpose: Genetic and environmental factors play significant roles in the pathogenesis of Parkinson's disease (PD). Recently, 17 novel risk loci of PD were identified in a meta-analysis of genome-wide association study (GWAS) in the European populations. In order to clarify if these risk loci are associated with PD in Taiwanese population, we conducted a case-control study including 14 of the novel risk loci and analyzed the genetic distribution and allele frequency. Read More

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Observation and measurement of applied anatomical features for thoracic intervertebral foramen puncture on computed tomography images.

World J Clin Cases 2021 Jun;9(18):4607-4616

Department of Pain Management, Nanjing Drum Tower Hospital, Clinical College of Xuzhou Medical University, Nanjing 210008, Jiangsu Province, China.

Background: Thoracic intervertebral foramen puncture is the key step for interventional therapy on the thoracic nerve roots or dorsal root ganglia. The anatomical features of the thoracic spine are complex, and puncture injury to the pleura, blood vessels, spinal cord, and other tissues may cause serious complications. The spatial anatomical characteristics and related parameters for thoracic intervertebral foramen puncture remain poorly understood. Read More

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Social-capital determinants of the women with diabetes: a population-based study.

J Diabetes Metab Disord 2021 Jun 9;20(1):511-521. Epub 2021 May 9.

Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Social-capital level contributes to clinical factors and health outcomes of patients suffering from diabetes. Considering the social determinants of type 2 diabetes patients could benefit to prevention of diabetes complications especially in women population. This study aims to determine social capital determinants in women with diabetes. Read More

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Predictive Value of Inflammation Biomarkers in Patients with Portal Vein Thrombosis.

J Clin Transl Hepatol 2021 Jun 30;9(3):384-391. Epub 2021 Mar 30.

Department of Hepatopancreatobiliary Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Background And Aims: To investigate the usefulness of inflammation biomarkers to serve as a predictors of portal vein thrombosis (PVT) postoperatively (post) in patients with portal hypertension after splenectomy and periesophagogastric devascularization.

Methods: A total of 177 liver cirrhosis patients were recruited from January 2013 to December 2017. They were divided into a PVT group (=71) and a non-PVT group (=106), according to ultrasound examination findings at 7-day post. Read More

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Prevalence of adverse drug events in emergency departments. FARM-URG multi-center project.

Farm Hosp 2021 May 13;45(4):176-179. Epub 2021 May 13.

Department of Pharmacy, Hospital Universitari Son Llàtzer, Palma de Mallorca (Baleares). Spain..

Objective: Adverse drug events are a well-known cause of emergency department admissions. FARM-URG is a project promoted by  the REDFASTER working group of the Spanish Society of Hospital  Pharmacy. Its aim is to evaluate these adverse events through regular  prevalence measurements. Read More

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Assessing the Knowledge, Attitudes and Practices of COVID-19 among Quarantine Hotel Workers in China.

Healthcare (Basel) 2021 Jun 21;9(6). Epub 2021 Jun 21.

College of Modern Management, Yango University, Fuzhou 350015, China.

During the pandemic, quarantine hotel workers face a higher risk of infection while they host quarantine guests from overseas. This study's aim is to gain an understanding of the knowledge, attitudes, and practices (KAP) of quarantine hotel workers in China. A total of 170 participants took part in a cross-sectional survey to assess the KAP of quarantine hotel workers in China, during the COVID-19 pandemic. Read More

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Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS.

Nutrients 2021 Jun 20;13(6). Epub 2021 Jun 20.

Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, D-97080 Wuerzburg, Germany.

The interplay between inflammation and oxidative stress is a vicious circle, potentially resulting in organ damage. Essential micronutrients such as selenium (Se) and zinc (Zn) support anti-oxidative defense systems and are commonly depleted in severe disease. This single-center retrospective study investigated micronutrient levels under Se and Zn supplementation in critically ill patients with COVID-19 induced acute respiratory distress syndrome (ARDS) and explored potential relationships with immunological and clinical parameters. Read More

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Changes in opioid discharge prescriptions after primary total hip and total knee arthroplasty affect opioid refill rates and morphine milligram equivalents : an institutional experience of 20,000 patients.

Bone Joint J 2021 07;103-B(7 Supple B):103-110

Department of Orthopedic Surgery, Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, New York, New York, USA.

Aims: Due to the opioid epidemic in the USA, our service progressively decreased the number of opioid tablets prescribed at discharge after primary hip (THA) and knee (TKA) arthroplasty. The goal of this study was to analyze the effect on total morphine milligram equivalents (MMEs) prescribed and post-discharge opioid repeat prescriptions.

Methods: We retrospectively reviewed 19,428 patients undergoing a primary THA or TKA between 1 February 2016 and 31 December 2019. Read More

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Periprocedural risk factors for incomplete radiofrequency ablation of liver metastases from colorectal cancer: a single-center retrospective analysis.

Int J Hyperthermia 2021 ;38(1):985-994

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Objective: To explore independent risk factors for incomplete radiofrequency ablation (iRFA) of colorectal cancer liver metastases (CRLM) and evaluate adverse outcomes following iRFA.

Materials And Methods: Magnetic resonance imaging data of CRLM patients who received percutaneous RFA were randomized into training (70%) and validation set 1 (30%) data sets. An independent validation set 2 was derived from computed tomography scans. Read More

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A decision tree analysis on multiple factors related to menopausal symptoms.

Menopause 2021 07;28(7):772-786

School of Nursing, Emory University, Atlanta, GA.

Objectives: The purpose of this study was to examine the specific characteristics that were directly linked to menopausal symptoms of midlife women from four major racial/ethnic groups in the United States using a decision tree analysis.

Methods: This was a secondary analysis of the data from 1,027 midlife women from 2 larger Internet-based studies. The parent studies used the Midlife Women's Symptom Index with multiple questions on background characteristics and health and menopausal status. Read More

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The Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population.

Front Psychiatry 2021 7;12:665599. Epub 2021 Jun 7.

Laboratory for Traumatic Stress Studies and Center for Genetics and BioMedical Informatics Research, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

The adenylate cyclase activating polypeptide 1 (pituitary) receptor () gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of , rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. Read More

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Extended Ganglion Cell Layer Thickness Deviation Maps With OCT in Glaucoma Diagnosis.

Front Med (Lausanne) 2021 4;8:684676. Epub 2021 Jun 4.

Department of Ophthalmology, University of Erlangen-Nürnberg, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.

The aim of the present study was to investigate the diagnostic power of RGCL in the macula quantitatively and qualitatively by using a conventional and extended elliptic grid with deviation maps. Thickness of RGCL was measured using SPECTRALIS® OCT (Heidelberg Engineering, Heidelberg, Germany) in 150 eyes of 150 subjects of the Erlangen Glaucoma Registry (EGR; NTC00494923): 26 ocular hypertension (OHT), 39 pre-perimetric open-angle glaucoma (pre-OAG), 19 normal tension glaucoma (NTG), 34 primary open-angle glaucoma (POAG), 16 secondary open-angle glaucoma (SOAG), and 16 controls. Analysis of RGCL was done quantitatively (global value, GV) and qualitatively (qualitative total value, QTV) by using a color-coded point score for data of the common elliptic macular grid of deviation maps. Read More

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The Prognostic Value of New Index (LANR) Composed of Pre-operative Lymphocytes, Albumin, and Neutrophils in Patients With Resectable Colorectal Cancer.

Front Oncol 2021 25;11:610264. Epub 2021 May 25.

Colorectal Cancer Clinical Research Center of Hubei Province, Wuhan, China.

Inflammatory factors and nutritional status are critical to the prognosis of colorectal cancer patients. This study aimed to investigate the prognostic value of the combination of preoperative lymphocytes, albumin, and neutrophils (LANR) in patients with resectable colorectal cancer. A total of 753 patients with pathologically diagnosed primary colorectal cancer were included in the study. Read More

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[Relapse of ankylosing spondylitis and its predictors after withdrawal of tumor necrosis factor-α inhibitors: a 52-week follow-up study].

Nan Fang Yi Ke Da Xue Xue Bao 2021 May;41(5):633-639

Department of Rheumatology and TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To investigate the recurrence of ankylosing spondylitis (AS) that has been relieved by standard-dose adalimumab (ADA) after dose reduction or withdrawal of tumor necrosis factor-α inhibitor (TNFi) and explore the factors that predict AS occurrence.

Objective: This study was conducted among 63 patients with AS who reduced the dose of or discontinued TNFi after completing at least 12 treatment cycles with ADA (40 mg/2 weeks) to achieve ASAS20 improvement with a BATH disease activity index (BASDAI) < 4 for more than 8 weeks. The patients were followed up every 12 weeks for a total of 52 weeks, and the recurrence of AS, changes of BASDAI, C-reactive protein (CRP)-based disease activity score (ASDASCRP), low back pain (LBP) score, Bath Ankylosing Spondylitis Metrology Index (BASMI), CRP and ESR were recorded and analyzed. Read More

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