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Appetite and Energy Intake Regulation in Response to Acute Exercise.

Med Sci Sports Exerc 2021 Apr 7. Epub 2021 Apr 7.

Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO Department of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT Anschutz Health & Wellness Center at the University of Colorado, Anschutz Medical Campus, Aurora, CO Division of General Internal Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT Division of Geriatric Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO Rocky Mountain Regional Veterans Administration, Aurora, CO.

Purpose: To determine if energy intake and appetite regulation differ in response to an acute bout of resistance exercise (REx) vs aerobic exercise (AEx).

Methods: Physically inactive adults (n=24, 35±2% body fat, 50% female) completed 3 conditions: AEx (walking at 65-70% heart rate max for 45 minutes); REx (1-set to failure of 12 exercises); and sedentary control (SED). Each condition was initiated in the post-prandial state (35 minutes post breakfast). Read More

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Color compatibility between dental structures and three different types of ceramic systems.

BMC Oral Health 2021 Feb 17;21(1):75. Epub 2021 Feb 17.

Department of Prosthodontics and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, 32 Clinicilor Street, 400006, Cluj-Napoca, Romania.

Background: To assess color compatibility between dental structures (human enamel and dentine) and three different types of ceramic systems.

Methods: Samples (1 and 2 mm-thick) of extracted tooth (containing dentine and enamel areas) and three ceramic systems with different shades and opacities (HT-High Translucent, T-Translucent) were prepared for this study: Vita Suprinity-VS (HT, T; A1, A2, A3, A3.5, B2, C2, D2) (Vita Zahnfabrik); Vita Enamic-VE (HT, T; 1M1, 1M2, 2M2, 3M2) (Vita Zahnfabrik) and Noritake Super Porcelain EX-3-NKT (A1, A2, A3, A3. Read More

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February 2021

Can 3D-printing avoid discomfort-related implant removal in midshaft clavicle fractures? A four-year follow-up.

Arch Orthop Trauma Surg 2020 Oct 31. Epub 2020 Oct 31.

Department of Biomechanical Engineering, University of Twente, 7500 AE, Enschede, The Netherlands.

Introduction: Due to the variation in shape and curvature of the clavicle, plates often have to be adjusted during surgery to acquire a good fit. Poorly fitted plates can cause discomfort, eventually requiring implant removal. 3D-printed replicas of the fractured clavicle can assist in planning of the surgical approach, plate selection and, if necessary, adjustment of the plate prior to surgery. Read More

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October 2020

The diagnostic potential of low-field MRI in problematic total knee arthroplasties - a feasibility study.

J Exp Orthop 2020 Jul 31;7(1):59. Epub 2020 Jul 31.

University of Twente, Faculty of Engineering Technology, Biomechanical Engineering, postbus 217 7500 AE, Enschede, The Netherlands.

Purpose: Low-field MRI, allowing imaging in supine and weight-bearing position, may be utilized as a non-invasive and affordable tool to differentiate between causes of dissatisfaction after TKA ('problematic TKA'). However, it remains unclear whether low-field MRI results in sufficient image quality with limited metal artefacts. Therefore, this feasibility study explored the diagnostic value of low-field MRI concerning pathologies associated with problematic TKA's' by comparing low-field MRI findings with CT and surgical findings. Read More

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Integrated photonics multi-waveguide devices for optical trapping and Raman spectroscopy: design, fabrication and performance demonstration.

Beilstein J Nanotechnol 2020 27;11:829-842. Epub 2020 May 27.

Department of Imaging Physics, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, Netherlands.

We realized integrated photonics multi-waveguide devices for optical trapping and Raman spectroscopy of particles in a fluid. In these devices, multiple beams directed towards the device center lead to a local field enhancement around this center and thus counteract the effect of light concentration near the facets, which is a disadvantage of dual-waveguide traps. Thus, a trapping region is created around the center, where a single particle of a size in a wide range can be trapped and studied spectroscopically, free from the influence of surfaces. Read More

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The long and winding road to happiness: A randomized controlled trial and cost-effectiveness analysis of a positive psychology intervention for lonely people with health problems and a low socio-economic status.

Health Qual Life Outcomes 2020 Jun 2;18(1):162. Epub 2020 Jun 2.

Faculty of Behavioural, Management & Social Sciences, Department of Psychology, Health & Technology, Centre for eHealth and Wellbeing Research, University of Twente, Postbus 217, 7500 AE, Enschede, The Netherlands.

Background: Our objective was to evaluate the effectiveness and cost-effectiveness of the positive psychology intervention 'Happiness Route' compared to an active control condition in a vulnerable population with an accumulation of health and psychosocial problems.

Methods: We conducted a randomized, single-blind, actively-controlled, parallel group study in seven municipalities in the Netherlands. To be eligible, participants had to experience loneliness, health problems and low socio-economic status. Read More

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Risk factors for limited improvement after total trapeziometacarpal joint arthroplasty.

Health Qual Life Outcomes 2020 Mar 30;18(1):90. Epub 2020 Mar 30.

University Clinic for Hand, Hip and Knee Surgery, Department of Orthopaedics, Lægårdvej 12, 7500, Holstebro, Denmark.

Background: Trapeziometacarpal (TMC) osteoarthritis can be painful and cause disability for patients. Total joint replacement of the TMC joint provides a pseudo arthrosis with good restoration of the thumb motion and pain relief in most patients. But there is also a risk of no improvement following the operation. Read More

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Educational Resources in Craniofacial Surgery: The Case for User-Friendly Digital Simulators.

J Craniofac Surg 2020 Jun;31(4):931-933

The Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY.

Introduction: Digital simulators are potential solutions to challenges facing surgical education. The authors sought to evaluate the reach and utilization of a freely-accessible craniofacial surgery digital educational simulator. More importantly, we compare usage patterns between web-based and mobile-based platforms. Read More

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Covered stents versus Bare-metal stents in chronic atherosclerotic Gastrointestinal Ischemia (CoBaGI): study protocol for a randomized controlled trial.

Trials 2019 Aug 20;20(1):519. Epub 2019 Aug 20.

Department of Radiology, Erasmus MC University Medical Center, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

Background: Chronic mesenteric ischemia (CMI) is the result of insufficient blood supply to the gastrointestinal tract and is caused by atherosclerotic stenosis of one or more mesenteric arteries in > 90% of cases. Revascularization therapy is indicated in patients with a diagnosis of atherosclerotic CMI to relieve symptoms and to prevent acute-on-chronic mesenteric ischemia, which is associated with high morbidity and mortality. Endovascular therapy has rapidly evolved and has replaced surgery as the first choice of treatment in CMI. Read More

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Effects of a computerised guideline support tool on child healthcare professionals' response to suspicions of child abuse and neglect: a community-based intervention trial.

BMC Med Inform Decis Mak 2019 08 15;19(1):161. Epub 2019 Aug 15.

Department of Public Administration, Institute for Innovation and Governance Studies, University of Twente, P.O. Box 217, 7500 BK, Enschede, the Netherlands.

Background: Healthcare professionals' adherence to guidelines on child protection is not self-evident. This study assessed the effects of a computerised support tool on child healthcare professionals' adherence to the seven recommended guideline activities, and on time spent seeking information presented in this guideline.

Methods: A community-based intervention trial design was applied, comparing access to a paper-based guideline (control) with access to a paper-based guideline supplemented with a computerised guideline support tool (intervention). Read More

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Delay in surgery, risk of hospital-treated infections and the prognostic impact of comorbidity in hip fracture patients. A Danish nationwide cohort study, 2005-2016.

Clin Epidemiol 2019 10;11:383-395. Epub 2019 May 10.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N 8200, Denmark.

We examined the association between delay in surgery and hospital-treated infections in hip fracture patients with and without known comorbidities. All hip fracture patients aged ≥65 years registered in the Danish Multidisciplinary Hip Fracture Registry from 2005 to 2016 were included (n=72,520). Delay in surgery was defined as the time in hours from admission to surgery and was divided into 3 groups (12, 24 and 48 hrs). Read More

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B-positive: a randomized controlled trial of a multicomponent positive psychology intervention for euthymic patients with bipolar disorder - study protocol and intervention development.

BMC Psychiatry 2018 10 17;18(1):335. Epub 2018 Oct 17.

Center for eHealth and Well-being Research, Department of Psychology, Health, and Technology, University of Twente, PO Box 217, Enschede, 7500 AE, the Netherlands.

Background: Bipolar disorder (BD) is characterized by recurrent (hypo)manic and depressive episodes, alternating with euthymic states in which patients are relatively symptom free. Besides clinical recovery, it is important to also strive for improvement of mental well-being and personal recovery. One prominent field focussing on the improvement of well-being is positive psychology. Read More

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October 2018

Proposing novel TNFα direct inhibitor Scaffolds using fragment-docking based e-pharmacophore modeling and binary QSAR-based virtual screening protocols pipeline.

J Mol Graph Model 2018 10 24;85:111-121. Epub 2018 Aug 24.

Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey; Neuroscience Program, Institute of Health Sciences, Bahcesehir University, Istanbul, Turkey. Electronic address:

Tumor necrosis factor alpha (TNFα) is a homotrimer protein that plays a pivotal role for critical immune functions, including infection, inflammation and antitumor responses. It also plays a primary role in autoimmune diseases like rheumatoid arthritis (RA). So far, only biological therapeutics like infliximab, etanercept, and adalimumab are available as treatment of inflammatory diseases. Read More

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October 2018

Towards sustainable mental health promotion: trial-based health-economic evaluation of a positive psychology intervention versus usual care.

BMC Psychiatry 2018 08 23;18(1):265. Epub 2018 Aug 23.

Department of Public Mental Health, Trimbos Institute, Utrecht, The Netherlands.

Background: Mental well-being could be promoted and protected by positive psychology (PP) based interventions. Such interventions may be appealing for people at risk of anxiety and depressive disorders, but health-economic evaluations are scarce. The aim was to examine the cost-effectiveness of a PP intervention. Read More

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The effect of diaries written by relatives for intensive care patients on posttraumatic stress (DRIP study): protocol for a randomized controlled trial and mixed methods study.

BMC Nurs 2018 16;17:37. Epub 2018 Aug 16.

6Regional Hospital Holstebro, University Clinic for Hand, Hip and Knee Surgery, Aarhus University, Lægårdvej 12, 7500 Holstebro, Denmark.

Background: Critically ill patients and their relatives have complex needs for support during their stay in the intensive care unit (ICU) and the post-ICU rehabilitation period. Diaries written by nurses have proven beneficial for patients and relatives, preventing post-traumatic stress, anxiety and depression and helping patients and families find meaning. Actively involving relatives in writing a diary for critically ill patients is a new approach to helping relatives and patients cope; however, research is limited. Read More

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Kerala acute heart failure registry-Rationale, design and methods.

Indian Heart J 2018 Jul 13;70 Suppl 1:S118-S120. Epub 2018 Feb 13.

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. Electronic address:

Heart failure (HF) is recognized as a major public health problem in both the low and high- income countries. However, data are scarce on the burden, prevailing practice patterns and long-term health outcomes of HF patients in India. The Kerala heart failure registry (KHFR) is a multi-centric, prospective, and hospital based registry in Kerala, India. Read More

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Ergonomic assessment of the first assistant during robot-assisted surgery.

J Robot Surg 2019 Apr 24;13(2):283-288. Epub 2018 Jul 24.

Department of Surgery, Meander Medical Centre, Maatweg 3, 3813 TZ, Amersfoort, The Netherlands.

The use of the da Vinci robot in minimal invasive surgery comes with numerous advantages. Recent papers describe improvements in the ergonomic environment and benefits for the surgeon's posture in the console. Ergonomics for first assistants or scrub nurses at the OR table during robot-assisted procedures, however, have gained minor attention. Read More

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Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial.

Trials 2018 Apr 2;19(1):207. Epub 2018 Apr 2.

Department of Gastroenterology and Hepatology, Radboud University Medical Centre, PO 9101, 6500 HB, Nijmegen, The Netherlands.

Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication of ERCP and may run a severe course. Evidence suggests that vigorous periprocedural hydration can prevent PEP, but studies to date have significant methodological drawbacks. Importantly, evidence for its added value in patients already receiving prophylactic rectal non-steroidal anti-inflammatory drugs (NSAIDs) is lacking and the cost-effectiveness of the approach has not been investigated. Read More

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Local Anesthetic Injection Speed and Common Peroneal Nerve Block Duration: A Randomized Controlled Trial in Healthy Volunteers.

Reg Anesth Pain Med 2018 Jul;43(5):467-473

From the Department of Anesthesiology, Nordsjællands Hospital, University of Copenhagen, Hillerød Denmark.

Background And Objectives: The speed of local anesthetic (LA) injections in peripheral regional anesthesia ranges from slow continuous infusions (3-12 mL/h) to rapid manual injections (>7500 mL/h). Optimizing injection speed could augment the spread of LA toward the targeted nerves and influence nerve block characteristics. The objective of this study was to investigate whether injection speed of a single dose of LA affects peripheral nerve block duration. Read More

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Changes in medicine prescription following a medication review in older high-risk patients with polypharmacy.

Int J Clin Pharm 2018 Apr 17;40(2):480-487. Epub 2018 Feb 17.

Dept. Health Technology & Services Research Faculty of Behavioural, Management & Social Sciences, Universty of Twente, P.O. box 217, 7500, AE Enschede, Netherlands.

Background The more (inappropriate) drugs a patient uses, the higher the risk of drug related problems. To reduce these risks, medication reviews can be performed. Objective To report changes in the prescribed number of (potentially inappropriate) drugs before and after performing a medication review in high-risk polypharmacy patients. Read More

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Implementation and effects of Movement-oriented Restorative Care in a nursing home - a quasi-experimental study.

BMC Geriatr 2017 10 23;17(1):243. Epub 2017 Oct 23.

Zorggroep Solis, Postbus 5014, 7400 GC, Deventer, Netherlands.

Background: The prevalence of dementia is expected to increase rapidly, and institutionalization is a common consequence of the disease. Dependence in activities of daily living (ADL) is a predictor for institutionalization and a determinant for the quality of life (QoL). A promising method to increase functional independence in nursing homes is a restorative care or function focused care (FFC) approach. Read More

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October 2017

Circulation of DENV2 and DENV4 in Aedes aegypti (Diptera: Culicidae) mosquitoes from Praia, Santiago Island, Cabo Verde.

J Insect Sci 2017 Jul;17(4)

Departamento de Entomologia, Instituto Aggeu Magalhães/Fundação Oswaldo Cruz (IAM/FIOCRUZ-PE), Av. Professor Moraes Rego s/n, Cidade Universitária, Recife PE. 50670-420, Brazil.

Arthropod-borne viruses, such as Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV), pose a challenge to public health, due to their worldwide distribution and large-scale outbreaks. Dengue fever is currently one of the most important diseases and it is caused by four serotypes of DENV and is mainly transmitted by the mosquito Aedes aegypti. It is estimated that 50-100 million cases are reported every year worldwide. Read More

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The effect of pneumococcal conjugate vaccines on incidence and microbiology associated with complicated acute otitis media.

Int J Pediatr Otorhinolaryngol 2017 Oct 4;101:249-253. Epub 2017 Jul 4.

Department of Clinical Medicine, Aarhus University, DK-8200 Aarhus N, Denmark; Department of Otorhinolaryngology, Region Hospital Holstebro, DK-7500 Holstebro, Denmark.

Objectives: The objectives of this study were to investigate the incidence of complicated acute otitis media (cAOM) as well as the associated microbiology before and after introduction of the 7- and 13-valent pneumococcal conjugate vaccines (PCV-7 and -13), respectively. CAOM comprises "heavy" AOM (AOM demanding hospitalization), mastodismus (M) and acute mastoiditis (AM).

Methods: A retrospective cohort study of the incidence and microbiology associated with cAOM during the non-PCV era, the PCV-7 and 13 eras, respectively. Read More

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October 2017

Effect of tolvaptan on renal handling of water and sodium, GFR and central hemodynamics in autosomal dominant polycystic kidney disease during inhibition of the nitric oxide system: a randomized, placebo-controlled, double blind, crossover study.

BMC Nephrol 2017 Aug 15;18(1):268. Epub 2017 Aug 15.

University Clinic in Nephrology and Hypertension, Department of Medical Research, Holstebro Hospital and Aarhus University, Hospital Unit Jutland West, Laegaardvej 12, 7500, Holstebro, Denmark.

Background: Tolvaptan slows progression of autosomal dominant polycystic kidney disease (ADPKD) by antagonizing the vasopressin-cAMP axis. Nitric oxide (NO) stimulates natriuresis and diuresis, but its role is unknown during tolvaptan treatment in ADPKD.

Methods: Eighteen patients with ADPKD received tolvaptan 60 mg or placebo in a randomized, placebo-controlled, double blind, crossover study. Read More

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The effectiveness of the use of a digital activity coaching system in addition to a two-week home-based exercise program in patients after total knee arthroplasty: study protocol for a randomized controlled trial.

BMC Musculoskelet Disord 2017 Jul 5;18(1):290. Epub 2017 Jul 5.

Radboud Institute for Health Sciences, IQ Healthcare, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: There is consistent evidence that supervised programs are not superior to home-based programs after total knee arthroplasty (TKA), especially in patients without complications. Home-based exercise programs are effective, but we hypothesize that their effectiveness can be improved by increasing the adherence to physical therapy advice to reach an adequate exercise level during the program and thereafter. Our hypothesis is that an activity coaching system (accelerometer-based activity sensor), alongside a home-based exercise program, will increase adherence to exercises and the activity level, thereby improving physical functioning and recovery. Read More

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Omitting re-excision for focally positive margins after breast-conserving surgery does not impair disease-free and overall survival.

Breast Cancer Res Treat 2017 Jul 7;164(1):157-167. Epub 2017 Apr 7.

Department of Oncological Surgery, Erasmus MC Cancer Institute, DHA-102, PO Box 2400, 3000, Rotterdam, The Netherlands.

Purpose: In contrast to other countries, the Dutch breast cancer guideline does not recommend re-excision for focally positive margins after breast-conserving surgery (BCS) in invasive tumor and does recommend whole-breast irradiation including boost. We investigated whether omitting re-excision as compared to performing re-excision affects prognosis with a retrospective population-based cohort study.

Methods: The total cohort included 32,119 women with primary BCS for T1-T3 breast cancer diagnosed between 2003 and 2008 from the nationwide Netherlands cancer registry. Read More

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Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial.

Trials 2017 04 8;18(1):166. Epub 2017 Apr 8.

Department of Surgery, Academic Medical Center, PO Box 22660, Amsterdam, DD 1100, The Netherlands.

Background: Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking. Read More

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Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects.

BMC Nephrol 2017 Mar 13;18(1):86. Epub 2017 Mar 13.

University Clinic in Nephrology and Hypertension, Department of Medical Research, Holstebro Hospital, Aarhus University, Hospital Unit Jutland West, Laegaardvej 12, 7500, Holstebro, Denmark.

Background: Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron's principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and systemic hemodynamics, during baseline and NO-inhibition with L-NMMA (L-NG-monomethyl-arginine). Read More

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The effect of an organizational level participatory intervention in secondary vocational education on work-related health outcomes: results of a controlled trial.

BMC Public Health 2017 01 31;17(1):141. Epub 2017 Jan 31.

Netherlands Organization for Applied Scientific Research TNO, Work, Health and Technology, P.O. Box 3005, NL-2301 DA, Leiden, The Netherlands.

Background: Work-related stress is highly prevalent in the educational sector. The aim of the current study was to evaluate the effectiveness of an organizational level, participatory intervention on need for recovery and vitality in educational workers. It was hypothesized that the intervention would decrease need for recovery and increase vitality. Read More

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January 2017