Antibiotics (Basel) 2021 Feb 2;10(2). Epub 2021 Feb 2.
Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, via Cintia 4, 80126 Napoli, Italy.
Brullo is an Asteraceae plant species endemic to Lampedusa island, the largest island of the Pelage archipelago, Italy. The organic extract of its whole aerial parts, showing antibiotic activity against and , wasfractionated employing bioguided purification procedures affording three main farnesane-type sesquiterpenoids. They were identified by spectroscopic methods (NMR and ESIMS data) as the ()-3,7,11-trimethyldodeca-1,6,10-triene-3,9-diol, ()-10-hydroxy-2,6,10-trimethyldodeca-2,6,11- trien-4-one and ()-10-hydroxy-2,6,10-trimethyl-dodeca-6,11-dien-4-one, commonly named 9-hydroxynerolidol, 9-oxonerolidol, and chiliadenol B, respectively. Read More