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New predictive factors for prolonged operation time of laparoscopic posterior retroperitoneal adrenalectomy; retrospective cohort study.

Int J Surg 2021 Sep 14;94:106113. Epub 2021 Sep 14.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Background: Laparoscopic adrenalectomy is a standard surgical procedure for benign adrenal diseases. Laparoscopic posterior retroperitoneal adrenalectomy (LPRA) has many benefits. However, it is associated with factors such as prolong operation time. Read More

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September 2021

Non-invasive neurally adjusted ventilatory assist in preterm infants with RDS: effect of changing NAVA levels.

Eur J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Neonatology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

We aimed to examine the effect of changing levels of support (NAVA level) during non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants with respiratory distress syndrome (RDS) on electrical diaphragm activity. This is a prospective, single-centre, interventional, exploratory study in a convenience sample. Clinically stable preterm infants supported with NIV-NAVA for RDS were eligible. Read More

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September 2021

A Radiomics Signature-Based Nomogram to Predict the Progression-Free Survival of Patients With Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization Plus Radiofrequency Ablation.

Front Mol Biosci 2021 31;8:662366. Epub 2021 Aug 31.

Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention, Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, China.

The study aims to establish an magnetic resonance imaging radiomics signature-based nomogram for predicting the progression-free survival of intermediate and advanced hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation A total of 113 intermediate and advanced HCC patients treated with TACE and RFA were eligible for this study. Patients were classified into a training cohort ( = 78 cases) and a validation cohort ( = 35 cases). Radiomics features were extracted from contrast-enhanced T1W images by analysis kit software. Read More

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Value of multiphase contrast-enhanced CT with three-dimensional reconstruction in detecting depth of infiltration, lymph node metastasis, and extramural vascular invasion of gastric cancer.

J Gastrointest Oncol 2021 Aug;12(4):1351-1362

Department of Ultrasound, The Third Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background: Multiphase contrast-enhanced computed tomography (CECT) can reveal the location, morphology, size, and enhancement pattern of gastric cancer (GC), whereas the three-dimensional reconstruction (3DR) technique can better display the relationships of the lesions with surrounding structures, the feeding vessels, and lymph node metastasis. Here, we investigated the value of multi-phase CECT with 3DR in detecting depth of infiltration, lymph node metastasis, and extramural vascular invasion (EMVI) of GC.

Methods: The clinical and imaging data of 132 GC patients admitted to the Chongqing Hospital of Traditional Chinese Medicine and the Third Affiliated Hospital of Chongqing Medical University during the period from January 2012 to October 2019 were collected. Read More

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Treatment Patterns and Outcomes of Patients With Advanced Pleural Mesothelioma at an Academic Referral Centre.

Clin Lung Cancer 2021 Aug 10. Epub 2021 Aug 10.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

Background: Overall survival (OS) for malignant pleural mesothelioma (MPM) in vulnerable subgroups remains poorly understood with scarce data available to guide treatment decisions. The study describes real-world detailed treatment patterns and outcomes of patients with advanced MPM overall and specifically in elderly and poor performance status (PS) patients.

Methods: Retrospective chart review was performed for all patients with histologically confirmed MPM seen at University Health Network/Princess Margaret Cancer Centre (UHN-PM). Read More

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[Adherence to adjuvant with therapy imatinib in patients with gastrointestinal stromal tumor: a national multi-center cross-sectional study].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Sep;24(9):775-782

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To analyze the current adherence to imatinib in patients with gastrointestinal stromal tumors (GIST) in China and its influencing factors. A cross-sectional survey was conducted. Study period: from October 1, 2020 to November 31, 2020. Read More

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September 2021

Impact of Socioeconomic Factors on Prognosis and Clinical Management in Patients with Hepatocellular Carcinoma.

Turk J Gastroenterol 2021 Aug;32(8):667-677

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, China.

Background: The prognosis for patient survival using the tumor-node-metastasis (TNM) staging system may be imperfect, as it based only on biological factors and does not include the socioeconomic factors (SEFs). We integrated the SEFs into the TNM system (TNMSEF), and evaluated whether the novel TNM-SEF staging system showed better prediction capacity and improved clinical guidance in hepatocellular carcinoma (HCC).

Methods: We selected data of 12 514 cases with HCC between 2010 and 2015 from the SEER database. Read More

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Assessment of Red Cell Distribution Width, Platelet/lymphocyte Ratio, Systemic Immune-inflammation Index, and Neutrophil/lymphocyte Ratio Values in Patients with Central Retinal Artery Occlusion.

Ocul Immunol Inflamm 2021 Sep 15:1-5. Epub 2021 Sep 15.

Department of Ophthalmology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Purpose: To evaluate complete blood count (CBC)-derived inflammatory indices in central retinal artery occlusion (CRAO).

Methods: A total of 42 patients with CRAO (CRAO group) and 42 age- and sex-matched subjects without CRAO (Control group) were included. CBC parameters including red cell distribution width (RDW) levels were assayed. Read More

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September 2021

Trends and predictors of 30-day readmissions in subjects with eosinophilic esophagitis: results from a national cohort.

Dis Esophagus 2021 Sep 11. Epub 2021 Sep 11.

Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA.

Background: Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition causing recurrent dysphagia and may predispose patients to repeated hospitalizations. We assessed temporal trends and factors affecting readmissions in patients with EoE.

Methods: Patients with primary diagnosis of EoE and/or a complication (dysphagia, weight loss, and esophageal perforation) from EoE between 2010 and 2017 were identified from the National Readmissions Database using the International Classification of Diseases codes. Read More

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September 2021

Therapeutic efficacy of microwave coagulation versus liver resection for hepatocellular carcinoma within the Milan criteria: A propensity score matching analysis.

Eur J Surg Oncol 2021 Sep 7. Epub 2021 Sep 7.

Department of Hepatobiliary and Splenic Surgery, Department of General Surgery, Shengjing Hospital of China Medical University, China. Electronic address:

Introduction: This study aimed to compare the therapeutic efficacy of resection (RES) and microwave ablation (MWA) for hepatocellular carcinoma (HCC) within the Milan criteria.

Materials And Methods: Between 2011 and 2019, 426 HCC patients within the Milan criteria were treated at our institution (RES: n = 291; MWA: n = 135). We compared overall survival (OS), disease-free survival (DFS), complications, and hospital stay in these patients using propensity score matching (PSM) and determined the prognostic factors using multivariate Cox analysis. Read More

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September 2021

Evaluation of the Medicolegal Process in Neurosurgical Practice with A Scenario.

Turk Neurosurg 2021 ;31(5):667-670

Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey.

The main purpose of medicine is to protect humans from diseases and its complications. Patients may be at risk in the course of diseases or during medical and surgical treatments, which can have undesirable consequences, including death. These risks, which are accepted by all medical authorities and medical literature, are called "complications. Read More

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September 2021

First-Line Administration of Fibrinogen Concentrate in the Bleeding Trauma Patient: Searching for Effective Dosages and Optimal Post-Treatment Levels Limiting Massive Transfusion-Further Results of the RETIC Study.

J Clin Med 2021 Aug 31;10(17). Epub 2021 Aug 31.

Department of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Fibrinogen supplementation is recommended for treatment of severe trauma hemorrhage. However, required dosages and aimed for post-treatment fibrinogen levels remain a matter of discussion. Within the published RETIC study, adult patients suffering trauma-induced coagulopathy were randomly assigned to receive fibrinogen concentrate (FC) as first-line ( 50) or crossover rescue ( 20) therapy. Read More

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Surveillance of Antidepressant Safety (SADS): Active Signal Detection of Serious Medical Events Following SSRI and SNRI Initiation Using Big Healthcare Data.

Drug Saf 2021 Sep 8. Epub 2021 Sep 8.

Department of Drug Design and Pharmacology, Pharmacovigilance Research Center, University of Copenhagen, Copenhagen, Denmark.

Introduction: The current process for generating evidence in pharmacovigilance has several limitations, which often lead to delays in the evaluation of drug-associated risks.

Objectives: In this study, we proposed and tested a near real-time epidemiological surveillance system using sequential, cumulative analyses focusing on the detection and preliminary risk quantification of potential safety signals following initiation of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).

Methods: We emulated an active surveillance system in an historical setting by conducting repeated annual cohort studies using nationwide Danish healthcare data (1996-2016). Read More

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September 2021

Targeted Therapy for RET Fusion Lung Cancer: Breakthrough and Unresolved Issue.

Front Oncol 2021 23;11:704084. Epub 2021 Aug 23.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Molecular drugs targeting mutated or rearranged oncogene drivers have become one of the standard recognized treatments in patients with advanced and recurrent non-small cell lung cancer. is located in the long arm of human chromosome 10 and encodes a receptor tyrosine kinase protein, and RET fusion-positive lung adenocarcinoma occurs in 1%-2% of cases. Clinical trials of multikinase inhibitors, including cabozantinib, vandetanib, sorafenib, and lenvatinib, that inhibit RET oncogene activity have shown their antitumor efficacy. Read More

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Clinical and economic burden of obstructive hypertrophic cardiomyopathy in the United States.

J Med Econ 2021 Sep 8:1-29. Epub 2021 Sep 8.

St. Francis Hospital, Roslyn, NY, USA.

Aims:  Obstructive hypertrophic cardiomyopathy (oHCM) is a disease of the cardiomyocyte in which dynamic left ventricular outflow track obstruction may lead to heart failure, valvular disease, and sudden death. Little is known about healthcare resource utilization (HRU) and costs associated with oHCM. This study investigated the clinical and economic burden of oHCM in patients with or without symptoms associated with oHCM. Read More

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September 2021

Matrix metalloproteinases MMP-2 and MMP-9 as markers for the prediction of preeclampsia in the first trimester.

Ceska Gynekol 2021 ;86(4):228-235

Introduction: Preeclampsia is a life-threatening condition for the mother and foetus. Globally, it is dia-gnosed in 10 mil. women every year, which accounts for 3% to 8% of all pregnancies. Read More

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September 2021

Multitask Deep Learning for Segmentation and Classification of Primary Bone Tumors on Radiographs.

Radiology 2021 Sep 7:204531. Epub 2021 Sep 7.

From the Department of Radiology (C.E.v.S., V.S.S., Y.L., F.G.G., S.C.F., F.T.G., M.R.M., K.W., A.S.G.), Department for Orthopedics and Orthopedic Sports Medicine (N.J.W., C.K., R.v.E., R.B.), and Institute of Pathology (C.M.), Klinikum Rechts der Isar, Technische Universität München, Ismaninger Str 22, 81675 Munich, Germany; and the Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany (M.J., P.M.J., M.F.R.).

Background An artificial intelligence model that assesses primary bone tumors on radiographs may assist in the diagnostic workflow. Purpose To develop a multitask deep learning (DL) model for simultaneous bounding box placement, segmentation, and classification of primary bone tumors on radiographs. Materials and Methods This retrospective study analyzed bone tumors on radiographs acquired prior to treatment and obtained from patient data from January 2000 to June 2020. Read More

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September 2021

Clinical and Economic Outcomes of Using Robotic Versus Hand-Held Staplers During Robotic Lobectomy.

Innovations (Phila) 2021 Sep 6:15569845211040814. Epub 2021 Sep 6.

5116 Division of Thoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objective: During robotic lobectomy (RL), the surgeon can elect to use either robotic staplers or hand-held laparoscopic staplers. It is assumed that either will result in similar outcomes, while robotic staplers increase cost. We sought to compare perioperative outcomes and costs between RL cases that utilized robotic staplers versus hand-held staplers in real-world clinical practice. Read More

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September 2021

Insurance Status Effect on Laryngeal Cancer Survival: A Population Based Study.

Ann Otol Rhinol Laryngol 2021 Sep 4:34894211044231. Epub 2021 Sep 4.

Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Objective: To analyze insurance status effect on overall survival (OS) and disease-specific survival (DSS) in laryngeal cancer.

Study Design: Cross-sectional population analysis.

Setting: Surveillance, Epidemiology, and End Results (SEER) database. Read More

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September 2021

Time to resolution of respiratory and systemic COVID-19 symptoms in community setting.

Clin Microbiol Infect 2021 Sep 2. Epub 2021 Sep 2.

Covidom regional telemedicine platform, Assistance Publique-Hôpitaux de Paris, Paris, France; Cardiology department, University Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin Bicêtre, France.

Objectives: During the Coronavirus disease 2019 (COVID-19), symptom course among outpatients is not well known. Our aim was to assess the time to resolution of respiratory and systemic symptoms and their associated factors.

Methods: Cohort study including adult outpatients, managed with Covidom, a telesurveillance solution, with RT-PCR confirmed diagnosis, from March 9 2020 until February 23 2021. Read More

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September 2021

The Utility of Hepatobiliary Scintigraphy Scans in the Tokyo Guidelines Era for Acute Cholecystitis.

J Surg Res 2021 Sep 1;268:667-672. Epub 2021 Sep 1.

Department of Surgery, Montefiore Medical Center, Bronx, New York. Electronic address:

Background: Hepatobiliary Scintigraphy (HIDA) aids the diagnosis of acute cholecystitis (AC) but has limitations. We sought to design a model based on the Tokyo Guidelines 2018 (TG18) to predict HIDA results.

Methods: A retrospective review of patients who underwent a HIDA scan during the evaluation of AC was performed. Read More

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September 2021

Characterization of CD66b and its relationship between immune checkpoints and their synergistic impact in the prognosis of surgically resected lung adenocarcinoma.

Lung Cancer 2021 Aug 28;160:84-91. Epub 2021 Aug 28.

Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address:

Objectives: CD66b positive tumor-infiltrating neutrophils (TINs) are key immunity cells in the tumor microenvironment (TME). However, their relationship with clinicopathological features, immune checkpoints (ICs), and prognostic value remains undetermined in lung adenocarcinoma (LUAD). In this study, we aimed to characterize the infiltration by TINs and the prognostic significance in patients with surgically resected LUAD. Read More

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Long-Term Outcomes Following Drug-Eluting Balloons Versus Thin-Strut Drug-Eluting Stents for Treatment of In-Stent Restenosis (DEB-Dragon-Registry).

Circ Cardiovasc Interv 2021 Sep 3:CIRCINTERVENTIONS121010868. Epub 2021 Sep 3.

Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland (P.N., J.K.).

Background: Data regarding the use of percutaneous coronary intervention with drug-eluting balloons (DEB) versus thin-strut drug-eluting stents (thin-DES) for treating DES in-stent restenosis in everyday clinical practice is scarce. Our goal was to evaluate the efficacy and safety profile of DEB versus thin-DES in DES in-stent restenosis.

Methods: Consecutive patients with DES in-stent restenosis who underwent percutaneous coronary intervention between 2008 and 2019 entered the multicenter DEB-DRAGON Registry with a follow-up of 3 years. Read More

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September 2021

Comparative effectiveness and persistence of TNFi and non-TNFi in juvenile idiopathic arthritis: a large paediatric rheumatology centre in the USA.

Rheumatology (Oxford) 2021 Sep;60(9):4063-4073

Department of Pediatrics, University of Cincinnati College of Medicine.

Objective: To evaluate the persistence and effectiveness of TNF inhibitors (TNFi) vs non-TNFi among newly diagnosed JIA patients after initiation of biologic DMARD (bDMARD).

Methods: Using longitudinal patient-level data extracted from electronic medical records in a large Midwestern paediatric hospital from 2009 to 2018, we identified JIA patients initiating TNFi and non-TNFi treatment. Treatment effectiveness was assessed based on disease activity. Read More

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September 2021

Trans-ethnic genome-wide association study of severe COVID-19.

Commun Biol 2021 08 31;4(1):1034. Epub 2021 Aug 31.

College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of Chinese ancestry. We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. Read More

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Differentiating Benign from Malignant Renal Tumors Using T2- and Diffusion-Weighted Images: A Comparison of Deep Learning and Radiomics Models Versus Assessment from Radiologists.

J Magn Reson Imaging 2021 Aug 30. Epub 2021 Aug 30.

Department of Medical Imaging, Clinic Medical School, Yangzhou University, Northern Jiangsu Province Hospital, Yangzhou, China.

Background: Differentiating benign from malignant renal tumors is important for selection of the most effective treatment.

Purpose: To develop magnetic resonance imaging (MRI)-based deep learning (DL) models for differentiation of benign and malignant renal tumors and to compare their discrimination performance with the performance of radiomics models and assessment by radiologists.

Study Type: Retrospective. Read More

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The reliability and validity of the Scott Triggers for gastrointestinal surgery patients in China.

Asian J Surg 2021 Aug 28. Epub 2021 Aug 28.

Department of Anesthesia Surgery, Shanxi Provincial People's Hospital, Taiyuan, 030012, China. Electronic address:

Objective: Scott Triggers is designed to identify potential surgical patients at risk for development of pressure injuries. But it has not been validated for sensitivity and positive predictive value to date. This study aimed to evaluate the reliability and validity of the Scott Triggers for the gastrointestinal surgery patients in China. Read More

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Epidemiological Insights from 1,652 Patients with Spinal Tuberculosis Managed at a Single Center: A Retrospective Review of 5-Year Data.

Asian Spine J 2021 Sep 1. Epub 2021 Sep 1.

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Study Design: Retrospective cohort.

Purpose: To report the demographic characteristics, clinico-radiological presentation, laboratory findings, and outcomes of "middlepath" treatment in patients with spinal tuberculosis from a single public healthcare facility in a developing country.

Overview Of Literature: Tuberculosis is a global health problem that is endemic in developing countries and undergoing resurgence in developed ones. Read More

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September 2021

Sagittal age-adjusted score (SAAS) for adult spinal deformity (ASD) more effectively predicts surgical outcomes and proximal junctional kyphosis than previous classifications.

Spine Deform 2021 Aug 30. Epub 2021 Aug 30.

Department of Orthopedics, Hospital for Special Surgery, 525 E 71st St., Belaire 4E, New York, NY, 10021, USA.

Background: Several methodologies have been proposed to determine ideal ASD sagittal spinopelvic alignment (SRS-Schwab classification) global alignment and proportion (GAP) score, patient age-adjusted alignment). A recent study revealed the ability and limitations of these methodologies to predict PJK. The aim of the study was to develop a new approach, inspired by SRS classification, GAP score, and age-alignment to improve the evaluation of the sagittal plane. Read More

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Eye injuries from fireworks used during celebrations and associated vision loss: the international globe and adnexal trauma epidemiology study (IGATES).

Graefes Arch Clin Exp Ophthalmol 2021 Aug 28. Epub 2021 Aug 28.

National Healthcare Group Eye Institute at Tan Tock Seng Hospital, Singapore, 308433, Singapore.

Purpose: To report on the factors associated with severe vision loss from fireworks-related ocular trauma during celebrations, including festivals.

Methods: Tertiary eye care hospitals in 5 countries and private ophthalmology practices in the Netherlands. Patients included received treatment for fireworks-related ocular trauma during celebrations. Read More

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