Polymers (Basel) 2021 Feb 17;13(4). Epub 2021 Feb 17.
Department of Cell Biology, Genetics and Physiology, Faculty of Science, University of Málaga, IBIMA, 29071 Málaga, Spain.
Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Read More