60 results match your criteria 56000 orthopaedic


Type II Collagen-Conjugated Mesenchymal Stem Cells Micromass for Articular Tissue Targeting.

Biomedicines 2021 Jul 23;9(8). Epub 2021 Jul 23.

Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Clinical Block, Jalan Yaacob Latiff, Cheras, Kuala Lumpur 56000, Malaysia.

The tissue engineering approach in osteoarthritic cell therapy often requires the delivery of a substantially high cell number due to the low engraftment efficiency as a result of low affinity binding of implanted cells to the targeted tissue. A modification towards the cell membrane that provides specific epitope for antibody binding to a target tissue may be a plausible solution to increase engraftment. In this study, we intercalated palmitated protein G (PPG) with mesenchymal stem cells (MSCs) and antibody, and evaluated their effects on the properties of MSCs either in monolayer state or in a 3D culture state (gelatin microsphere, GM). Read More

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Periodontal disease in seropositive rheumatoid arthritis: scoping review of the epidemiological evidence.

Germs 2021 Jun 2;11(2):266-286. Epub 2021 Jun 2.

Prof. Dr., MBChB, MS (Orth), Orthopaedic Department, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia.

The link between periodontal disease (PD) and rheumatoid arthritis (RA) has been hypothesized to lie in the anti-cyclic citrullinated protein antibody (ACPA) molecules present in seropositive RA. This review aimed to discuss how RA and specifically ACPA-positive RA link to PD, and appraise the epidemiological evidence on the relationship between ACPA-positive RA and PD. Articles were searched following the PRISMA guideline across the MEDLINE, Web of Science, Scopus and Cochrane Library databases. Read More

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Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine.

Stem Cells Int 2021 19;2021:2616807. Epub 2021 Aug 19.

Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Kuala Lumpur, Malaysia.

Cell therapy involves the transplantation of human cells to replace or repair the damaged tissues and modulate the mechanisms underlying disease initiation and progression in the body. Nowadays, many different types of cell-based therapy are developed and used to treat a variety of diseases. In the past decade, cell-free therapy has emerged as a novel approach in regenerative medicine after the discovery that the transplanted cells exerted their therapeutic effect mainly through the secretion of paracrine factors. Read More

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A Malaysian Delphi consensus on managing knee osteoarthritis.

BMC Musculoskelet Disord 2021 Jun 4;22(1):514. Epub 2021 Jun 4.

Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: The 2013 Malaysian Clinical Practice Guidelines on the Management of Osteoarthritis (OA) recommend a linear step-up approach to manage knee OA. However, patients with knee OA often require a multimodal approach to address OA-related pain symptoms and functional limitations. This consensus aimed to provide doctors with an updated set of evidence-based, clinical experience-guided recommendations to manage knee OA. Read More

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Tissue-Engineered Hydroxyapatite Bone Scaffold Impregnated with Osteoprogenitor Cells Promotes Bone Regeneration in Sheep Model.

Tissue Eng Regen Med 2021 06 27;18(3):377-385. Epub 2021 May 27.

Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Jalan Ya'acob Latif, Bandar Tun. Razak, 56000, Cheras, Kuala Lumpur, Malaysia.

Background: Managing massive bone defects, a great challenge to orthopaedics reconstructive surgery. The problem arise is the supply of suitable bone is limited with many complications. Tissue-engineered hydroxyapatite bone (TEHB) scaffold impregnated with osteoprogenitor cells developed as an alternative to promote bone regeneration. Read More

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Establishing SW1353 Chondrocytes as a Cellular Model of Chondrolysis.

Life (Basel) 2021 Mar 25;11(4). Epub 2021 Mar 25.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Osteoarthritis (OA) is the most common degenerative joint disease characterised by chondrocyte cell death. An in vitro model of chondrocyte cell death may facilitate drug discovery in OA management. In this study, the cytotoxicity and mode of cell death of SW1353 chondrocytes treated with 24 h of OA inducers, including interleukin-1β (IL-1β), hydrogen peroxide (HO) and monosodium iodoacetate (MIA), were investigated. Read More

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Prospect of Metal Ceramic (Titanium-Wollastonite) Composite as Permanent Bone Implants: A Narrative Review.

Materials (Basel) 2021 Jan 7;14(2). Epub 2021 Jan 7.

Department of Tissue Engineering, National University of Malaysia, Selangor Darul Ehsan 56000, Malaysia.

This literature review discusses the influence of titanium ceramic composites as a biomaterial towards the fabrication of implants for orthopedic applications. The concept of applying metal-ceramic composites enable many novel combinations in the design and fabrication of complex materials which enhances functionality to improve cell and tissue matrix interactions particularly in the formation of bone. Specific focus is placed on its plethora of materials selected from the metals and ceramic group and identifying the optimal combination that matches them. Read More

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January 2021

Telomere shortening is associated with poor physical performance in knee osteoarthritis.

Biomed Rep 2020 Oct 22;13(4):27. Epub 2020 Jul 22.

Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.

Telomere length is a hallmark characteristic of ageing and age-related diseases. Osteoarthritis (OA) is the most common cause of joint pain and physical disability in the elderly. Previous studies have revealed the role of telomere shortening in OA; however, the relationship between telomere length, muscle strength and physical performance in knee OA patients remains unknown. Read More

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October 2020

Molecular surveillance of methicillin-susceptible (MSSA) isolated over a one-year period from a Malaysian Teaching Hospital.

Germs 2020 Jun 2;10(2):104-111. Epub 2020 Jun 2.

PhD, UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Cheras, 56000 Kuala Lumpur, Malaysia.

Introduction: We report the results of a molecular surveillance study carried out on methicillin-susceptible (MSSA) isolated in a one-year duration from Hospital Canselor Tuanku Muhriz (HCTM), a tertiary hospital located in Kuala Lumpur, Malaysia.

Methods: The first strain isolated from each MSSA infection in HCTM during the year 2009 was included into the study. Antimicrobial susceptibility testing and agr group typing were carried out for all strains; virulence gene (, , TSST-1 and PVL) typing results of the strains were obtained from a previous study. Read More

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Clinical and bacteriological profile of diabetic foot infections in a tertiary care.

J Foot Ankle Res 2020 Jun 16;13(1):36. Epub 2020 Jun 16.

Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia Medical Centre, Hospital Canselor Tunku Muhriz, 56000, Cheras, Malaysia.

Background: Diabetic foot infection is a worldwide health problem is commonly encountered in daily practice. This study was conducted to identify the microbiological profile and antibiotic sensitivity patterns of causative agents identified from diabetic foot infections (DFIs). In addition, the assessment included probable risk factors contributing to infection of ulcers that harbour multidrug-resistant organisms (MDROs) and their outcomes. Read More

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Decreased Serum Adiponectin Reflects Low Vitamin D, High Interleukin 6, and Poor Physical Performance in Knee Osteoarthritis.

Arch Immunol Ther Exp (Warsz) 2020 May 24;68(3):16. Epub 2020 May 24.

Department of Orthopaedics, Vinai Parkpian Orthopaedic Research Center, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, 1873 Rama IV Road, Patumwan, Bangkok, 10330, Thailand.

Obesity is a major contributor to deterioration of physical function toward sarcopenia in knee osteoarthritis (OA) due to its effect mediated through adipokines-derived molecules that have pro-/anti-inflammatory properties. This study aimed to investigate relationships of serum adiponectin, 25-hydroxyvitamin D (25(OH)D), interleukin (IL)-6, and physical performance in knee OA patients. A total of 175 knee OA patients and 52 healthy controls were recruited. Read More

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3D Culture of MSCs on a Gelatin Microsphere in a Dynamic Culture System Enhances Chondrogenesis.

Int J Mol Sci 2020 Apr 13;21(8). Epub 2020 Apr 13.

Tissue Engineering Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Recent advancement in cartilage tissue engineering has explored the potential of 3D culture to mimic the in vivo environment of human cartilaginous tissue. Three-dimensional culture using microspheres was described to play a role in driving the differentiation of mesenchymal stem cells to chondrocyte lineage. However, factors such as mechanical agitation on cell chondrogenesis during culture on the microspheres has yet to be elucidated. Read More

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Pes anserine syndrome in post knee arthroplasty. A rare case report.

J Clin Orthop Trauma 2020 Jan-Feb;11(1):171-174. Epub 2018 Nov 20.

Department of Orthopedics and Traumatology, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000, Cheras, Kuala Lumpur, Malaysia.

Pes anserine syndrome is a cause of inferomedial knee pain. It occurs in patients with diabetes mellitus, osteoarthritis, rheumatoid arthritis and in overweight patients. It is a challenge to identify the causes of knee pain following knee replacement surgery. Read More

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November 2018

Development of Rheumatoid Arthritis Classification from Electronic Image Sensor Using Ensemble Method.

Sensors (Basel) 2019 Dec 27;20(1). Epub 2019 Dec 27.

Faculty of Engineering, Technology and Built Environment, UCSI University, 56000 Kuala Lumpur, Malaysia.

Rheumatoid arthritis (RA) is an autoimmune illness that impacts the musculoskeletal system by causing chronic, inflammatory, and systemic effects. The disease often becomes progressive and reduces physical function, causes suffering, fatigue, and articular damage. Over a long period of time, RA causes harm to the bone and cartilage of the joints, weakens the joints' muscles and tendons, eventually causing joint destruction. Read More

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December 2019

Facilitators and Barriers to the Rehabilitation Workforce Capacity Building in Low- to Middle-Income Countries.

Phys Med Rehabil Clin N Am 2019 11 24;30(4):867-877. Epub 2019 Aug 24.

Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

An increase in population and chronic conditions leading to disability require increasing emphasis on rehabilitation and health intervention. Poorer countries do not usually have the rehabilitation workforce needed to promote societal inclusion and participation. The roles of the rehabilitation workforce were often not clearly defined, leading to task shifting among rehabilitation professionals. Read More

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November 2019

Rehabilitation in Malaysia.

Phys Med Rehabil Clin N Am 2019 11 5;30(4):807-816. Epub 2019 Sep 5.

Rehabilitation Medicine Unit, Department of Orthopedic and Traumatology, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.

This article reviews the epidemiology, rehabilitation intervention strategies, and rehabilitation resources for persons with disabilities (PWD) in Malaysia. Currently, the registered number of PWD is 409,269 individuals, 1.3% of the total population, which is far less than the World Health Organization estimation of 10%. Read More

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November 2019

The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate.

Int J Environ Res Public Health 2019 08 13;16(16). Epub 2019 Aug 13.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, Malaysia.

Osteoarthritis is a degenerative joint disease which primarily affects the articular cartilage and subchondral bones. Since there is an underlying localized inflammatory component in the pathogenesis of osteoarthritis, compounds like tocotrienol with anti-inflammatory properties may be able to retard its progression. This study aimed to determine the effects of oral tocotrienol supplementation on the articular cartilage and subchondral bone in a rat model of osteoarthritis induced by monosodium iodoacetate (MIA). Read More

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Effect of a Fracture Liaison Service on the Rate of Subsequent Fracture Among Patients With a Fragility Fracture in the Norwegian Capture the Fracture Initiative (NoFRACT): A Trial Protocol.

JAMA Netw Open 2018 12 7;1(8):e185701. Epub 2018 Dec 7.

Department of Clinical Medicine, Arctic University of Norway, Tromsø, Norway.

Importance: Fragility fracture is a major health issue because of the accompanying morbidity, mortality, and financial cost. Despite the high cost to society and personal cost to affected individuals, secondary fracture prevention is suboptimal in Norway, mainly because most patients with osteoporotic fractures do not receive treatment with antiosteoporotic drugs after fracture repair.

Objectives: To improve secondary fracture prevention by introducing a standardized intervention program and to investigate the effect of the program on the rate of subsequent fractures. Read More

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December 2018

Are Cardiac Complications Associated With Other Adverse Events? A Look at 56,000 Orthopaedic Trauma Patients.

J Surg Orthop Adv Fall 2018;27(3):198-202

The Vanderbilt Orthopaedic Institute Center for Health Policy, Nashville, Tennessee; e-mail:

The purpose of this study was to identify those complications for which patients with adverse cardiac events are at risk within the 30-day postoperative period following treatment oforthopaedic trauma cases. This was a retrospective cohort study of orthopaedic trauma patients in the United States between 2006 and 2013. A total of 56,336 patients meeting any one of 89 CPT codes in the American College of Surgeons National Surgical Quality Improvement Program database were used. Read More

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February 2019

Activities of Daily Living and Determinant Factors among Older Adult Subjects with Lower Body Fracture after Discharge from Hospital: A Prospective Study.

Int J Environ Res Public Health 2018 05 16;15(5). Epub 2018 May 16.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.

Fracture is a type of musculoskeletal injury that contributes to an inability to perform daily activities. The objective of this study was to evaluate activities of daily living (ADL) of older adult patients with lower body fracture and to determine factors influencing ADL. Patient's ADL was assessed at pre-fracture, ward admission and post-discharge phases using the Katz ADL questionnaire. Read More

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Long-term evaluation of osteoarthritis sheep knee, treated with TGF-β3 and BMP-6 induced multipotent stem cells.

Exp Gerontol 2018 04 3;104:43-51. Epub 2018 Feb 3.

Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, K.L, Malaysia; Department of Physiology, Medical Faculty, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif Bandar Tun Razak Muda Abdul Aziz, Campus, 56000 K.L, Malaysia.. Electronic address:

Background: Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting regeneration. We evaluated the treatment of osteoarthritis by chondrogenically induced ADSCs and BMSCs for a long time functional recovery. Read More

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Consensus recommendations for managing osteoarthritic pain with topical NSAIDs in Asia-Pacific.

Pain Manag 2018 Mar 18;8(2):115-128. Epub 2017 Dec 18.

Rehabilitation Center, Bach Mai Hospital, Hanoi, Vietnam.

Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain. Read More

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The evaluation of cartilage differentiations using transforming growth factor beta3 alone and with combination of bone morphogenetic protein-6 on adult stem cells.

Cell Tissue Bank 2017 Sep 30;18(3):355-367. Epub 2017 Jun 30.

Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia.

In our quest to standardize our formula for a clinical trial, transforming growth factor-beta3 (TGF-β3) alone and in combination with bone morphogenetic protein-6 (BMP-6) were evaluated for their effectiveness in cartilage differentiation. Bone Marrow Stem Cells (BMSCs) and Adipose Derived Stem Cells (ADSCs) were induced to chondrogenic lineage using two different media. Native chondrocytes served as positive control. Read More

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September 2017

The Sternal Management Accelerated Recovery Trial (S.M.A.R.T) - standard restrictive versus an intervention of modified sternal precautions following cardiac surgery via median sternotomy: study protocol for a randomised controlled trial.

Trials 2017 06 23;18(1):290. Epub 2017 Jun 23.

Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, VIC, 3053, Australia.

Background: The routine implementation of sternal precautions to prevent sternal complications that restrict the use of the upper limbs is currently worldwide practice following a median sternotomy. However, evidence is limited and drawn primarily from cadaver studies and orthopaedic research. Sternal precautions may delay recovery, prolong hospital discharge and be overly restrictive. Read More

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Anatomic Variation in Morphometry of Human Coracoid Process among Asian Population.

Biomed Res Int 2017 6;2017:6307019. Epub 2017 Apr 6.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Ethnic origin plays an important role in bone morphometry. Studies examining the influence of coracoid process have focused primarily on adults and have not included people from diverse Asian ethnic backgrounds. Our goal was to explore ethnic differences in morphometry of coracoid among Asian population. Read More

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February 2018

Drivers of hospital length of stay in 56,000 orthopaedic trauma patients: The impact of postoperative cardiac events.

J Clin Orthop Trauma 2017 Jan-Mar;8(1):45-49. Epub 2017 Feb 9.

The Vanderbilt Orthopaedic Institute Center for Health Policy, 1215 21st Avenue South, Suite 4200 Medical Center East, South Tower, Nashville, TN 37232 (615), United States.

Purpose: To determine whether postoperative cardiac complications following orthopaedic trauma treatment are associated with longer lengths of stay.

Methods: This was a retrospective cohort study. We analyzed orthopaedic trauma patients in the United States for whom data was collected in the ACS-NSQIP database between the years of 2006 and 2013. Read More

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February 2017

Polycaprolactone Triol-Citrate Scaffolds Enriched with Human Platelet Releasates Promote Chondrogenic Phenotype and Cartilage Extracellular Matrix Formation.

Tissue Eng Regen Med 2017 Apr 9;14(2):93-101. Epub 2017 Mar 9.

2Department of Orthopedic Surgery, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

In this paper we report the differentiating properties of platelet-rich plasma releasates (PRPr) on human chondrocytes within elastomeric polycaprolactone triol-citrate (PCLT-CA) porous scaffold. Human-derived chondrocyte cellular content of glycosaminoglycans (GAGs) and total collagen were determined after seeding into PCLT-CA scaffold enriched with PRPr cells. Immunostaining and real time PCR was applied to evaluate the expression levels of chondrogenic and extracellular gene markers. Read More

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Corrigendum to "Adverse cardiac events in 56,000 orthopaedic trauma patients: Does anatomic area make a difference?" [Injury 47 (2016) 1856-1861].

Injury 2016 12 5;47(12):2838-2840. Epub 2016 Oct 5.

Vanderbilt Orthopaedics Institute Center for Health Policy, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:

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December 2016

Intra-Rater Reliability and Minimal Detectable Change of Vertical Ground Reaction Force Measurement during Gait and Half-Squat Tasks on Healthy Male Adults.

Malays J Med Sci 2016 Mar;23(2):21-7

Institute of Visual Informatics, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.

Background: The understanding of vertical ground reaction force (VGRF) during walking and half-squatting is necessary and commonly utilised during the rehabilitation period. The purpose of this study was to establish measurement reproducibility of VGRF that reports the minimal detectable changes (MDC) during walking and half-squatting activity among healthy male adults.

Methods: 14 male adults of average age, 24. Read More

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Association of Cobb angle progression and neuraxial abnormality on MRI in asymptomatic Adolescent Idiopathic Scoliosis.

Med J Malaysia 2016 06;71(3):122-5

Universiti Kebangsaan Malaysia Medical Centre, Department of Radiology, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.

Background: Detection of neuraxial abnormality in neurologically asymptomatic adolescent idiopathic scoliosis (AIS) is crucial prior to surgery. It can only be detected on magnetic resonance imaging (MRI), which was not routinely done in this group of patient. On the other hand, whole spine radiographs for measurement of Cobb angle have been routinely included during clinic follow-up. Read More

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