81,112 results match your criteria 5-year survival

Acute respiratory deterioration in rheumatoid arthritis-associated interstitial lung disease: a single-center study.

Chest 2022 Jan 12. Epub 2022 Jan 12.

Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Background: Interstitial lung disease (ILD) is associated with increased morbidity and mortality in rheumatoid arthritis (RA). Moreover, acute exacerbation (AE) is a devastating complication of RA-ILD. However, there is little data on AE in RA-ILD. Read More

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January 2022

Development and future prospective of treatment for localized prostate cancer with high-intensity focused ultrasound.

J Med Ultrason (2001) 2022 Jan 15. Epub 2022 Jan 15.

Department of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

High-intensity focused ultrasound (HIFU) was experimentally used for focal therapy for anti-cancer effects in prostate cancer (PC). Focal therapy is a diagnosis-based investigational treatment option for localized PC that cures clinically significant PC (csPC) while preserving the anatomical structures related to urinary and sexual function based on its spread observed using multi-parametric magnetic resonance imaging (mpMRI). The European Association of Urology indicated that the current status of focal therapy for localized PC was an investigational modality and encouraged prospective recording of outcomes and recruitment of suitable patients in 2018. Read More

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January 2022

Complications following novel therapies for non-small cell lung cancer.

J Intern Med 2022 Jan 15. Epub 2022 Jan 15.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

The emergence of tyrosine kinase inhibitors and immune checkpoint inhibitors has paved a new era for the management of non-small cell lung cancer, which has for many years lacked major clinical breakthroughs. Historically, 5-year overall survival remained below 5% in individuals with metastatic disease. These novel treatments have led to significant prolongation of survival in the locally advanced and metastatic setting, exceeding 25% in selected populations. Read More

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January 2022

Survival, treatment regimens and medical costs of women newly diagnosed with metastatic triple-negative breast cancer.

Sci Rep 2022 Jan 14;12(1):729. Epub 2022 Jan 14.

Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Individuals diagnosed with metastatic triple-negative breast cancer (mTNBC) suffer worse survival rates than their metastatic non-TNBC counterparts. There is little information on survival, treatment patterns, and medical costs of mTNBC patients in Asia. Therefore, this study aimed to examine 5-year survival, regimens of first-line systemic therapy, and healthcare costs of mTNBC patients in Taiwan. Read More

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January 2022

Long-term exposure to road traffic noise and all-cause and cause-specific mortality: a Danish Nurse Cohort study.

Sci Total Environ 2022 Jan 11:153057. Epub 2022 Jan 11.

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Long-term road traffic noise exposure is linked to cardio-metabolic disease morbidity, whereas evidence on mortality remains limited.

Objectives: We investigated association of long-term exposure to road traffic noise with all-cause and cause-specific mortality.

Methods: We linked 22,858 females from the Danish Nurse Cohort (DNC), recruited into the Danish Register of Causes of Death up to 2014. Read More

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January 2022

Fast-Track Failure After Cardiac Surgery: Risk Factors and Outcome With Long-Term Follow-Up.

J Cardiothorac Vasc Anesth 2021 Dec 16. Epub 2021 Dec 16.

Department of Anesthesiology, University Hospitals of Leuven, Leuven, Belgium; Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address:

Objectives: An important cornerstone of the Enhanced Recovery After Cardiac Surgery initiative is a fast-track cardiac anesthesia management protocol. Fast-track failure has been described to have a detrimental impact on immediate postoperative outcomes. The authors here evaluated risk factors for short- and long-term effects of fast-track failure. Read More

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December 2021

Population-level trends and outcomes of sentinel lymph node biopsy in vulvar cancer surgery in the United States.

Gynecol Oncol 2022 Jan 11. Epub 2022 Jan 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

Objective: To examine population-level trends, characteristics, and outcomes related to nodal assessment for vulvar cancer surgery in the United States.

Methods: This is a retrospective cohort study querying the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. The study population was 5604 women with T1b or T2-smaller(≤4 cm) squamous cell carcinoma of the vulva who underwent primary vulvectomy from 2003 to 2018. Read More

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January 2022

Optimizing use of L-asparaginase-based treatment of adults with acute lymphoblastic leukemia.

Blood Rev 2021 Nov 12:100908. Epub 2021 Nov 12.

Hematology Adolescent and Young Adult Unit, Saint Louis Hospital, URP-3518, Université de Paris, Paris, France. Electronic address:

Acute lymphoblastic leukemia (ALL) is a malignancy of lymphoid progenitor cells occurring at an annual incidence rate of approximately 1.1 to 2.1 per 100,000 person-years globally. Read More

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November 2021

Optimal surgery and lymph node metastasis of duodenal bulbar neuroendocrine neoplasms.

Eur J Surg Oncol 2021 Aug 4. Epub 2021 Aug 4.

Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan.

Background: There is no consensus on the extent of nodal dissection for duodenal bulbar NENs (neuroendocrine neoplasms).

Materials And Methods: We constructed and analyzed a combined dataset consisting of the patients who received surgery in our hospital and the patients from the literature based on a systematic review. The incidence, risk factors and location of nodal metastases were examined. Read More

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Long-term outcome of adjunctive Gamma Knife radiosurgery in skull-base chordomas and chondrosarcomas: An Indian experience.

J Clin Neurosci 2022 Jan 11;96:90-100. Epub 2022 Jan 11.

Department of Pathology, P D Hinduja National Hospital, Mumbai 400016, India.

Skull-base chordomas (CD) and chondrosarcomas (CS) are locally-invasive tumors, have similar clinical presentations, while differing in their nature of growth and outcomes. In this study, we compare the long-term outcomes of Gamma Knife Radiosurgery (GKRS) as an adjunctive treatment modality for residual skull-base CD and CS. A retrospective analysis of clinico-radiological, pathological, radiotherapeutic and outcome data was carried out in patients who underwent adjunctive GKRS for residual skull-base CD and CS at P D Hinduja Hospital, Mumbai, between 1997 and 2020. Read More

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January 2022

Full-thickness scar resection following R1/Rx excised T1 colorectal cancers as alternative to completion surgery.

Am J Gastroenterol 2021 Dec 31. Epub 2021 Dec 31.

Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands.

Introduction: Local full-thickness resections of the scar (FTRS) following local excision of a T1 CRC with uncertain resection margins is proposed as alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.

Methods: A large cohort of consecutive T1 CRCs between 2000 and 2017 was used. Read More

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December 2021

MRI-Guided Transurethral Ultrasound Ablation of Prostate Cancer: A Systematic Review.

J Endourol 2022 Jan 14. Epub 2022 Jan 14.

Mayo Clinic Florida, 23389, Jacksonville, Florida, United States;

Purpose: Magnetic resonance imaging-guided transurethral ultrasound ablation (TULSA) uses real-time MR thermometry feedback to target prostate disease. We systematically review the literature to synthesize efficacy, functional, and safety outcomes and assess the influence of planned ablation fraction on outcome.

Materials And Methods: PubMed, Embase, and the Cochrane Library were searched from inception to June 2021 following PRISMA guidelines. Read More

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January 2022

A novel three-microRNA signature for predicting survival in patients with nasopharyngeal carcinoma.

J Dent Sci 2022 Jan 8;17(1):377-388. Epub 2021 Sep 8.

Medical Research Center, Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, Guangdong, China.

Background/purpose: Nasopharyngeal carcinoma (NPC) is a malignant neoplasm of the head and neck. This study aims to use integrated bioinformatics technologies to develop a predictive miRNA-signature correlated with the prognosis of NPC.

Materials And Methods: Initially, the differentially expressed miRNAs (DEMs) in NPC were identified, and then DEMs related to the prognosis of NPC were further screened. Read More

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January 2022

Invasive Breast Carcinoma with Neuroendocrine Differentiation: A Single-Center Analysis of Clinical Features and Prognosis.

Geburtshilfe Frauenheilkd 2022 Jan 18;82(1):68-84. Epub 2021 Nov 18.

Department of Obstetrics and Gynaecology, University of Düsseldorf, Düsseldorf, Germany.

Invasive breast cancer with neuroendocrine differentiation is a rare subtype of breast malignancy. Due to frequent changes in the definition of these lesions, the correct diagnosis, estimation of exact prevalence, and clinical behaviour of this entity may be challenging. The aim of this study was to evaluate the prevalence, clinical features, and outcomes in a large cohort of patients with breast cancer with neuroendocrine differentiation. Read More

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January 2022

The Pretreatment Controlling Nutritional Status Score in Ovarian Cancer: Influence on Prognosis, Surgical Outcome, and Postoperative Complication Rate.

Geburtshilfe Frauenheilkd 2022 Jan 10;82(1):59-67. Epub 2022 Jan 10.

Division of General Gynecology and Gynecologic Oncology, Department of Obstetrics and Gynecology, Gynecologic Cancer Unit, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

The Controlling Nutritional (CONUT) Status score is an established predictor of impaired prognosis in patients with solid tumors. The aim of this study was to investigate the prognostic value of the CONUT score for overall survival and perioperative complication rates in patients with epithelial ovarian cancer. In this retrospective study we assessed the data of 337 consecutive patients with ovarian cancer. Read More

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January 2022

Aortic valve repair for the treatment of rheumatic aortic valve disease: a systematic review and meta-analysis.

Sci Rep 2022 Jan 13;12(1):674. Epub 2022 Jan 13.

Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.

Valvuloplasty for rheumatic aortic valve disease remains controversial. We conducted this study to explore whether aortic valvuloplasty is appropriate for the rheumatic population. A comprehensive search was conducted, and 7 eligible retrospective studies were identified from PubMed, Embase, Medline and Cochrane (up to April 7, 2020) according to the inclusion and exclusion criteria. Read More

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January 2022

Large tumour volume reduction of IDH-mutated anaplastic glioma involving the insular region following radiotherapy.

BMC Neurol 2022 Jan 13;22(1):24. Epub 2022 Jan 13.

Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia.

Background: The impact of near-total resection of IDH-mutated anaplastic glioma (IDHmutAG) is well-established but there remains uncertainty of benefit in tumours of the insular cortex where the extent of safe resection may be limited. This study aimed to assess tumour volume reduction in patients following IMRT and impact of residual post-surgical volume.

Methods And Materials: Patients with IDHmutAG involving insular cortex managed with IMRT from 2008 to 2019 had baseline patient, tumour and treatment factors recorded. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

Comparative Outcomes for Mature T and NK/T-cell Lymphomas in People with and without HIV and to AIDS-Defining Lymphomas.

Blood Adv 2022 Jan 13. Epub 2022 Jan 13.

Beth Israel Deaconess Medical Center, United States.

There are no studies comparing the prognosis for mature T-cell lymphoma (TCL) in people with human immunodeficiency virus (PWH) to people without HIV (PWoH) and to AIDS-defining B-cell lymphomas (A-BCL) in the modern antiretroviral therapy (ART) era. NA-ACCORD and COMPLETE are cohorts that enroll patients diagnosed with HIV and TCL, respectively. In our study 52, 64, 101, 500 and 246 PWH with histological confirmation of TCL, primary CNS, Burkitt's, diffuse large B-cell lymphoma (DLBCL) and Hodgkin's lymphoma (HL) respectively and 450 TCL without HIV were eligible for analysis. Read More

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January 2022


Presse Med 2022 Jan 10:104109. Epub 2022 Jan 10.

Clinic of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.

PCBCLs are a group of Non-Hodgkin's B-cell lymphomas originating in and usually confined to the skin, representing approximately one fourth of primary cutaneous lymphomas (PCL). Their current classification system has been the result of the joint World Health Organization (WHO) - European Organization for Research and Treatment of Cancer (EORTC) consensus in 2018. To date, several types of PCBCLs have been described in the scientific literature, with different clinical presentation and prognosis. Read More

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January 2022

Long-term auditory follow-up in the management of pediatric platinum-induced ototoxicity.

Eur Arch Otorhinolaryngol 2022 Jan 13. Epub 2022 Jan 13.

Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168, Rome, Italy.

Purpose: Irreversible bilateral sensorineural hearing loss is a common side effect of platinum compounds. Because of the extended overall survival, a prolonged hearing surveillance and management of hearing impairments are emerging concerns for pediatric oncology.

Methods: In this retrospective observational study, we enrolled 38 children out of 116 treated at our institution by chemotherapy (cisplatin and/or carboplatin) with or without irradiation between 2007 and 2014, submitted to hearing monitoring before every cycle of chemotherapy, and who completed a 5-year long-term audiological follow-up. Read More

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January 2022

Antegrade femoral nailing in the lateral decubitus position: a case series, technical tips and review of literature.

Eur J Orthop Surg Traumatol 2022 Jan 13. Epub 2022 Jan 13.

Virginia Commonwealth University, Richmond, VA, USA.

Background: Femoral intramedullary nailing is traditionally performed with the patient supine on a fracture table. We aimed to describe a case series of femoral intramedullary nailing for fracture in the lateral position, with discussion of the operative technique.

Methods: A retrospective analysis identified 52 patients who underwent femoral intramedullary nailing performed in a lateral position without traction over a 5-year period at a single level 1 trauma center. Read More

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January 2022

Development and validation of Pyroptosis‑related lncRNAs prediction model for bladder cancer.

Biosci Rep 2022 Jan 13. Epub 2022 Jan 13.

Sichuan University West China Hospital, Chengdu, China.

Bladder cancer is one of the highly heterogeneous disorders accompanied by a poor prognosis. This study aimed to construct a model based on pyroptosis‑related lncRNA to evaluate the potential prognostic application in bladder cancer. The mRNA expression profiles of bladder cancer patients and corresponding clinical data were downloaded from the public database from The Cancer Genome Atlas (TCGA). Read More

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January 2022

Factors of Recurrence After Complete Response in Children with Neuroblastoma: A 16-Year Retrospective Study of 179 Cases.

Cancer Manag Res 2022 6;14:107-122. Epub 2022 Jan 6.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China.

Background: It is not clear which known adverse prognostic factors of neuroblastoma are closely associated with tumor recurrence after complete response. We analyzed the factors for post-remission recurrence in children with neuroblastoma through a retrospective study.

Methods: A total of 179 children with neuroblastoma who achieved initial complete response were included in this study. Read More

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January 2022

Autophagy-Dependent Ferroptosis-Related Signature is Closely Associated with the Prognosis and Tumor Immune Escape of Patients with Glioma.

Int J Gen Med 2022 6;15:253-270. Epub 2022 Jan 6.

Laboratory of Molecular Neurobiology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, People's Republic of China.

Background: Ferroptosis is an autophagy-dependent form of cell death, sometimes called "ferritinophagy". Its related pathway has been proven to regulate the programmed death of glioma stem cells. Mining autophagy-dependent ferroptosis-related gene (AD-FRG) signature could facilitate the discovery of mechanisms and therapeutic targets showing drug resistance to chemotherapeutic drugs. Read More

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January 2022

Development and Validation of Nomograms to Predict Overall Survival Outcomes in Serous Ovarian Cancer Patients with Satisfactory Cytoreductive Surgery and Chemotherapy.

Int J Gen Med 2022 6;15:123-131. Epub 2022 Jan 6.

Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Nanning, Guangxi, People's Republic of China.

Objective: Nomograms are statistics-based predictive tools that integrate predictive factors. Herein, a nomogram was developed and validated to predict the overall survival (OS) in serous ovarian cancer (SOC).

Methods: Primary SOC patients with satisfactory cytoreductive surgery, chemotherapy, and OS ≥1 month were included in this study. Read More

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January 2022

Annual surgeon and hospital volume of gastrectomy and gastric adenocarcinoma survival in a population-based cohort study.

Acta Oncol 2022 Jan 13:1-8. Epub 2022 Jan 13.

Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

Background: It is uncertain whether centralization of gastrectomy to fewer surgeons and larger centers improves survival in gastric adenocarcinoma in Western populations. The aim of this study was to examine if higher annual surgeon or hospital volumes of gastrectomy increase gastric adenocarcinoma survival in a population-based Swedish cohort.

Methods: This study included almost all patients who underwent curatively intended gastrectomy for gastric adenocarcinoma in Sweden between 2006 and 2015 with follow-up throughout 2020. Read More

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January 2022

Correlation between Preoperative Serum Albumin-Globulin Ratio and Prognosis of Patients Undergoing Low Rectal Cancer Surgery.

Clin Lab 2022 Jan;68(1)

Background: To explore the correlation between preoperative serum albumin-globulin ratio (AGR) and the prognosis of patients undergoing low rectal cancer surgery.

Methods: A total of 152 patients treated from June 2013 to June 2015 were selected. They were divided into survival group (n = 128) and death group (n = 24). Read More

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January 2022

Characterization of m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration in acute myeloid leukemia.

Cancer Med 2022 Jan 13. Epub 2022 Jan 13.

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Previous studies have confirmed the existence of epigenetic regulation of immune responses in acute myeloid leukemia. However, the potential role of RNA N6-methyladenosine (m6A) remodeling in tumor microenvironment (TME) infiltration remains unclear.

Methods And Materials: m6A patterns of 469 AML patients (420 of which provided survival data) based on 18 m6A regulators were systematically evaluated. Read More

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January 2022

Effect of Preoperative Treatment on the Performance of Predictive Nomograms in Primary Retroperitoneal Sarcoma.

Ann Surg Oncol 2022 Jan 13. Epub 2022 Jan 13.

Department of Surgical Oncology, Princess Margaret Cancer Centre/Mount Sinai Hospital, Toronto, ON, Canada.

Background: Retroperitoneal sarcoma (RPS)-specific nomograms provide estimates of survival and recurrence risk following resection in the individual patient. The effect of preoperative treatment on nomogram performance has not been previously examined. Our aim was to evaluate the predictive accuracy of existing RPS-specific nomograms in patients managed at our center, where the majority of patients received preoperative radiation. Read More

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January 2022