3 results match your criteria 484 polydispersity

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A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies.

Int J Nanomedicine 2017 11;12:4921-4935. Epub 2017 Jul 11.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.

The aim of the present work was to tackle the solubility issue of a biopharmaceutics classification system (BCS)-II drug, aceclofenac. Although a number of attempts to increase the aqueous solubility have been made, none of the methods were taken up for scale-up. Hence size reduction technique by a top-down approach using wet milling process was utilized to improve the solubility and, consequently, the dissolution velocity of aceclofenac. Read More

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October 2017

Lyotropic liquid crystalline nanoparticles of CoQ10: implication of lipase digestibility on oral bioavailability, in vivo antioxidant activity, and in vitro-in vivo relationships.

Mol Pharm 2014 May 17;11(5):1435-49. Epub 2014 Apr 17.

Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) , Sector 67, S.A.S. Nagar (Mohali), Punjab -160062, India.

The present investigation reports implications of the lipase digestibility of lyotropic liquid crystalline nanoparticles (LCNPs) on the oral bioavailability, in vivo antioxidant potential, and in vitro-in vivo relationship (IVIVR) of CoQ10 loaded LCNPs prepared from glyceryl monooleate (GLCQ) and phytantriol (PLCQ). Exhaustive optimization of the process variables was carried out, and optimized lyophilized formulations were found to have particle sizes of 140.45 ± 5. Read More

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Multiple apomucin translation products from human respiratory mucosa mRNA.

Eur J Biochem 1991 Mar;196(2):321-8

Unité No 16 de l'Institut National de la Santé et de la Recherche Médicale and Groupement de Recherche No 139, Centre National de la Recherche Scientifique, Lille, France.

Poly(A)-rich RNA was purified from a pool of five human tracheobronchial mucosa. After in vitro translation in a reticulocyte lysate and immunoprecipitation of the translated products, using either a polyclonal antiserum or a monoclonal antibody to deglycosylated respiratory mucin peptides, the products were characterized by SDS/PAGE. The respiratory mucin precursors migrated as a very large smear from almost the top of the resolving polyacrylamide gel to an area corresponding to a molecular mass of about 100 kDa. Read More

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