Ann Surg 2014 Oct;260(4):706-14; discussion 714-5
*Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and †Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA.
Objective: To determine the role of intestinal alkaline phosphatase (IAP) in enteral starvation-induced gut barrier dysfunction and to study its therapeutic effect as a supplement to prevent gut-derived sepsis.
Background: Critically ill patients are at increased risk for systemic sepsis and, in some cases, multiorgan failure leading to death. Years ago, the gut was identified as a major source for this systemic sepsis syndrome. Read More