Adv Exp Med Biol 2020 ;1131:93-129
2nd Department of Pathology, Semmelweis University, Budapest, Hungary.
Plasma membrane Ca transport ATPases (PMCA1-4, ATP2B1-4) are responsible for removing excess Ca from the cell in order to keep the cytosolic Ca ion concentration at the low level essential for normal cell function. While these pumps take care of cellular Ca homeostasis they also change the duration and amplitude of the Ca signal and can create Ca gradients across the cell. This is accomplished by generating more than twenty PMCA variants each having the character - fast or slow response, long or short memory, distinct interaction partners and localization signals - that meets the specific needs of the particular cell-type in which they are expressed. Read More