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Pregnancy Outcomes Following Laparoscopic and Open Surgery in Pelvis during Pregnancy: a Nationwide Population-based Study in Korea.

J Korean Med Sci 2021 Jul 26;36(29):e192. Epub 2021 Jul 26.

Department of Obstetrics and Gynecology, Korea University Guro Hospital, Seoul, Korea.

Background: Non-obstetric surgery during pregnancy is associated with adverse obstetric and fetal outcomes. The aim of this study was to investigate the risk of adverse pregnancy outcomes for women who underwent non-obstetric pelvic surgery during pregnancy compared with that of women that did not undergo surgery.

Methods: Study data from women who gave birth in Korea were collected from the Korea National Health Insurance claims database between 2006 and 2016. Read More

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Ceiling effects indicate a possible threshold structure for working alliance.

J Couns Psychol 2021 Jul 22. Epub 2021 Jul 22.

Department of Communication.

This review investigated whether ceiling effects on client-reported working alliance measures represent measurement artifacts or valid information related to the formation of the working alliance. Using data from two previously published meta-analyses, a total of 92 estimates of ceiling effects were calculated based on 37 studies with 6,439 participants. Analyses examined the size of ceiling effects, relation with demographic variables, type of alliance measure, and ceiling effect stability across sessions. Read More

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Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial.

Eur Heart J 2021 Jul 16. Epub 2021 Jul 16.

Stanford University, Stanford, CA, USA.

Aims : Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would improve economic and clinical outcomes compared with standard care.

Methods And Results : Overall, 1400 patients with stable chest pain in 11 centres were randomized to initial testing with CTCA with selective FFRCT (experimental group) or standard clinical care pathways (standard group). Read More

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Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma.

J Orthop Surg Res 2021 Jul 7;16(1):439. Epub 2021 Jul 7.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.

Background: Hyaluronan (HA) has been shown to play important roles in the growth, invasion, and metastasis of malignant tumors. KIAA1199, which has potent HA-degrading activity, has been reported to be expressed in various malignancies and associated with patient prognosis. However, there are no reports on the expression of KIAA1199 in osteosarcoma. Read More

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CT Quantification of COVID-19 Pneumonia at Admission Can Predict Progression to Critical Illness: A Retrospective Multicenter Cohort Study.

Front Med (Lausanne) 2021 17;8:689568. Epub 2021 Jun 17.

Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Early identification of coronavirus disease 2019 (COVID-19) patients with worse outcomes may benefit clinical management of patients. We aimed to quantify pneumonia findings on CT at admission to predict progression to critical illness in COVID-19 patients. This retrospective study included laboratory-confirmed adult patients with COVID-19. Read More

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SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia.

Pathogens 2021 Jun 20;10(6). Epub 2021 Jun 20.

Department of Epidemiology, Croatian Institute of Public Health, 10000 Zagreb, Croatia.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus with a pandemic spread. So far, a total of 349,910 SARS-CoV-2 cases and 7687 deaths were reported in Croatia. We analyzed the seroprevalence and neutralizing (NT) antibody response in the Croatian general population after the first (May-July 2020) and second (December 2020-February 2021) pandemic wave. Read More

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Primary care providers' role in newborn screening result notification for cystic fibrosis.

Can Fam Physician 2021 Jun;67(6):439-448

Family physician and clinician scientist, Professor, and Sydney G. Frankfort Chair in Family Medicine in the Department of Family and Community Medicine with the Sinai Health System and the University of Toronto.

Objective: To explore primary care providers' (PCPs') role in result notification for newborn screening (NBS) for cystic fibrosis (CF), given that expanded NBS has increased the number of positive screening test results, drawing attention to the role of PCPs in supporting families.

Design: Cross-sectional survey and qualitative interviews.

Setting: Ontario. Read More

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The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia.

Cancer Med 2021 Jul 2;10(14):4864-4873. Epub 2021 Jun 2.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

Background: Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this age group and the genetic basis of relapse is a key goal as patients with relapsed/refractory disease have poor outcomes with conventional chemotherapy and novel molecular targets are required. This study examines the question of whether TYA T-ALL has a specific biological-molecular profile distinct from pediatric or adult T-ALL. Read More

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HERV-K(HML7) Integrations in the Human Genome: Comprehensive Characterization and Comparative Analysis in Non-Human Primates.

Biology (Basel) 2021 May 14;10(5). Epub 2021 May 14.

Laboratory of Molecular Virology, Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Cagliari, Italy.

Endogenous Retroviruses (ERVs) are ancient relics of infections that affected the primate germ line and constitute about 8% of our genome. Growing evidence indicates that ERVs had a major role in vertebrate evolution, being occasionally domesticated by the host physiology. In addition, human ERV (HERV) expression is highly investigated for a possible pathological role, even if no clear associations have been reported yet. Read More

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Do cancer survivors change their diet after cancer diagnosis?

Support Care Cancer 2021 May 24. Epub 2021 May 24.

Sydney Medical School, University of Sydney, Sydney, Australia.

Background: Improvements in lifestyle such as diet and exercise can minimise the risk of a new cancer diagnosis or cancer recurrence. We investigated dietary changes and supplement use by survivors attending Sydney Cancer Survivorship Centre (SCSC) clinic to plan future interventions to help survivors improve their diet.

Methods: Eligible survivors were SCSC cancer patients who had completed anticancer treatment with curative intent and attended their initial clinic between September 2013 and July 2019. Read More

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The Effect of Body Mass Index on Initial Breast Cancer Stage Among Korean Women.

Clin Breast Cancer 2021 Apr 22. Epub 2021 Apr 22.

Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The relationship between obesity and breast cancer stage is not well-known in the Korean population. This study aimed to identify the effect of body mass index (BMI) on initial breast cancer stage.

Patients And Methods: Among patients who underwent surgery for breast cancer (stages 0-III) from June 2003 to December 2018, we analyzed 4510 patients for whom there were BMI data. Read More

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[Analysis of the clinical characteristics and prognosis of 36 cases of newly diagnosed multiple myeloma patients with bone marrow monoclonal plasma cell ratio of less than 10].

Zhonghua Xue Ye Xue Za Zhi 2021 Apr;42(4):295-301

Peking Union Medical College, Chinese Academy of Medical Sciences & Department of Hematology, Peking Union Medical College Hospital, Beijing 100730, China.

To improve the understanding of newly diagnosed multiple myeloma (NDMM) patients with bone marrow (BM) monoclonal plasma cell ratio of less than 10%. The clinical characteristics, laboratory examination, response to treatment, and prognosis of 36 NDMM patients with BM plasma cell ratio of less than 10% at Peking Union Medical College Hospital from January 2009 to December 2017 were summarized retrospectively. In the same period, other age- and gender-matched 72 NDMM patients were selected as the control group, whose BM plasma cell ratio was equal to or greater than 10%. Read More

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To What Extent Can Digitally-Mediated Team Communication in Children's Physical Health and Mental Health Services Bring about Improved Outcomes? A Systematic Review.

Child Psychiatry Hum Dev 2021 May 8. Epub 2021 May 8.

Centre for Applied Autism Research, Department of Psychology, University of Bath, Bath, BA2 7AY, UK.

Digital communication technologies can be used for team consultation, case management, and information sharing in health and mental health services for children and young people (CYP). The objective of the systematic review was to investigate the evidence as to whether digitally-mediated team communication for CYP improves outcomes. We searched PsycINFO, PubMed, Web of Science, and Cochrane Library for relevant studies. Read More

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What can we learn from surveys? A systematic review of survey studies addressing femoroacetabular impingement syndrome.

J Hip Preserv Surg 2020 Aug 29;7(3):439-447. Epub 2020 Oct 29.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

The purpose of this study was to systematically review the methodology, response rate and quality of survey studies related to femoroacetabular impingement (FAI) syndrome. A search was conducted on three databases (PubMed, EMBASE, MEDLINE) for relevant studies from database inception to 27 January 2020. Data extracted included study and survey characteristics, as well as response rates. Read More

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Detailed analysis of in-hospital costs for adult patients with type III intestinal failure: A single-center study with global implications.

JPEN J Parenter Enteral Nutr 2021 Apr 30. Epub 2021 Apr 30.

Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, Australia.

Background: Home parenteral nutrition (HPN) is the recommended treatment for patients with type III intestinal failure (IF). However, owing to IF's rarity, the economic cost of managing these patients is not well understood. These patients often develop complications resulting in readmissions, which in turn contribute to ongoing costs. Read More

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Is treated hypertension associated with a lower 1-year mortality among older multimorbid residents of long-term care facilities?

Pol Arch Intern Med 2021 05 20;131(5):439-446. Epub 2021 Apr 20.

Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Faculty of Medicine, University Hospital in Kraków, Kraków, Poland.

Introduction: Long-term care facility (LTCF) residents are typically excluded from clinical trials due to multimorbidity, dementia, and frailty, so there are no clear evidence-based rules for treating arterial hypertension in this population. Moreover, the role of hypertension as mortality risk factor in LTCFs has not yet been clearly established.

Objectives: The study aimed to investigate whether treated hypertension is associated with lower mortality among older LTCF residents with multimorbidity. Read More

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Predictors of Quality of Life Improvement with Escitalopram and Adjunctive Aripiprazole in Patients with Major Depressive Disorder: A CAN-BIND Study Report.

CNS Drugs 2021 Apr 16;35(4):439-450. Epub 2021 Apr 16.

Department of Psychiatry, University of British Columbia, 5950 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada.

Background: Non-response to first-line treatment for major depressive disorder (MDD) is common; for such individuals, quality of life (QoL) impairments can be severe. Identifying predictors of QoL changes may support the management of cases with persistent depressive symptoms despite adequate initial pharmacological/psychological treatment.

Objective: The present study aimed to explore predictors of domain-specific QoL improvement following adjunctive aripiprazole treatment for inadequate response to initial antidepressant therapy. Read More

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Current practice patterns of society of urologic oncology members in performing inguinal lymph node staging/therapy for penile cancer: A survey study.

Urol Oncol 2021 07 26;39(7):439.e9-439.e15. Epub 2021 Mar 26.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Objectives: Inguinal lymph node (ILN) staging and therapeutic procedures are important for the diagnosis and management of suspected Inguinal lymph node metastasis in the setting of penile cancer. Morbidity associated with inguinal lymph node dissection (ILND) and the lack of standardization in its perioperative management are both significant. In this study, we aimed to define current management approaches and potential opportunities for improving outcomes. Read More

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Evaluating Race and Time to Transplantation in Multiple Myeloma: The Mount Sinai Hospital Experience.

Clin Lymphoma Myeloma Leuk 2021 Jul 16;21(7):439-443. Epub 2021 Feb 16.

Division of Hematology Oncology, Mount Sinai Hospital, New York, NY.

Background: Previous studies have found that Black patients with multiple myeloma undergo autologous stem-cell transplantation (ASCT) less frequently than their white counterparts, although the factors leading to decreased access and utilization have not been fully elucidated.

Patients And Methods: To identify whether racial differences in transplantation timing played a role in these disparities, we retrospectively analyzed 410 Black and white patients who received their first transplant at The Mount Sinai Hospital between 2011 and 2016 (260 white and 150 Black patients). We compared the time from initial diagnosis to stem-cell collection and the time from collection to transplantation between the 2 races while controlling for age, socioeconomic status, and functional status. Read More

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Cardiopulmonary Exercise Testing in Combined Pulmonary Fibrosis and Emphysema.

Respiration 2021;100(5):395-403. Epub 2021 Mar 3.

Department of Internal Medicine, University Medicine, Greifswald, Germany.

Background: Combined pulmonary fibrosis and emphysema (CPFE) is a distinct entity among fibrosing lung diseases with a high risk for lung cancer and pulmonary hypertension (PH). Notably, concomitant PH was identified as a negative prognostic indicator that could help with early diagnosis to provide important information regarding prognosis.

Objectives: The current study aimed to determine whether cardiopulmonary exercise testing (CPET) can be helpful in differentiating patients having CPFE with and without PH. Read More

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Prognostic value of olfactory evoked potentials in patients with post-infectious olfactory dysfunction.

Eur Arch Otorhinolaryngol 2021 Mar 1. Epub 2021 Mar 1.

Department of Otolaryngology, Smell and Taste Center, Beijing Anzhen Hospital, Capital Medical University, Anzhen Road 2, Chaoyang District, Beijing, 100029, China.

Purpose: Prognostic assessment of patients with post-infectious olfactory dysfunction (PIOD) poses a challenge for clinicians. While there have been some studies on the prognostic factors of PIOD focusing on demographic factors, the aim of this study was to investigate whether event-related potentials (ERPs) could be used as a new predictor of olfactory recovery in PIOD.

Methods: This was a retrospective study involving patients who underwent olfactory examinations using Sniffin' Sticks test before treatment and after 1 year of follow-up. Read More

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The 'Tommy Atkins' mango genome reveals candidate genes for fruit quality.

BMC Plant Biol 2021 Feb 22;21(1):108. Epub 2021 Feb 22.

School of Plants and Environmental Sciences, Virginia Tech, Ag Quad Lane, Blacksburg, VA, 24061, USA.

Background: Mango, Mangifera indica L., an important tropical fruit crop, is grown for its sweet and aromatic fruits. Past improvement of this species has predominantly relied on chance seedlings derived from over 1000 cultivars in the Indian sub-continent with a large variation for fruit size, yield, biotic and abiotic stress resistance, and fruit quality among other traits. Read More

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February 2021

COVID-19 experience in mainland China: Nursing lessons for the United States of America.

Nurs Forum 2021 Apr 3;56(2):439-443. Epub 2021 Feb 3.

School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

COVID-19 emerged in Wuhan, China, and began its worldwide journey. As the severity of the virus became known, the Chinese National Government mobilized resources, and their centralized management was critical to the containment of the epidemic. Healthcare agencies and providers were overwhelmed with patients, many of whom were critically ill and died. Read More

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Medication Adherence in Pediatric Patients with Bipolar Disorder: A Systematic Review.

J Child Adolesc Psychopharmacol 2021 Mar 18;31(2):86-94. Epub 2021 Jan 18.

Department of Child and Adolescent Psychiatry, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Pediatric bipolar disorder is a severe disabling condition affecting 1%-3% of youth worldwide. Both acute and maintenance treatment with medications are mainstays of treatment. It is well established in adult literature that adherence to medications improves outcomes and many adult studies have examined factors impacting adherence. Read More

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The Effect of Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) on Liver Enzymes, Glucose, and Lipid Profile.

Drug Des Devel Ther 2020 15;14:5515-5520. Epub 2020 Dec 15.

Infectious Diseases Unit ASST-MONZA, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy.

Objective: We aimed to investigate the effect of switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) on the hepatic safety and metabolic profile.

Methods: Consecutive HIV patients, enrolled in the Surveillance Cohort Long-term Toxicity Antiretrovirals/Antivirals (SCOLTA) project, switching from TDF to TAF were included. Changes from baseline (T0) to 6-month follow-up (T1) were evaluated using paired -test and signed rank test. Read More

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December 2020

New onset of type 2 diabetes as a complication after cancer diagnosis: A systematic review.

Cancer Med 2021 01 23;10(2):439-446. Epub 2020 Dec 23.

Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Florida, Gainesville, FL, USA.

Background: Despite improved survival rates, cancer survivors are experiencing worse health outcomes with complications of treatment, such as type 2 diabetes mellitus (T2D), that may deteriorate survivorship. The purpose of this review was to provide a comprehensive review of T2D incidence following cancer diagnosis.

Methods: The study included: (1) cohort studies, (2) cancer diagnosis by a doctor, (3) incidence of T2D after diagnosis of cancer, and (4) adult patients over 18 years. Read More

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January 2021

Long-term follow-up of patients with a high critical shoulder angle and acromion index: is there an increased retear risk after arthroscopic supraspinatus tendon repair?

JSES Int 2020 Dec 12;4(4):882-887. Epub 2020 Aug 12.

Department of Orthopedic Surgery, Shoulder Care Institute, AZ Delta Hospital, Roeselare, Belgium.

Background: The effect of the acromion index (AI) and critical shoulder angle (CSA) on the short-term healing rate after arthroscopic repair of the supraspinatus tendons is already known. Long-term effects have not been published yet.

Purpose: Long-term evaluation of the effect of the AI and CSA on the postoperative healing rate and clinical results after arthroscopic repair of the supraspinatus tendon. Read More

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December 2020

CT features of coronavirus disease 2019 (COVID-19) with an emphasis on the vascular enlargement pattern.

Eur J Radiol 2021 Jan 27;134:109442. Epub 2020 Nov 27.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China. Electronic address:

Purpose: The vascular enlargement (VE) pattern differs from previously described imaging patterns for pneumonia. This study aimed to investigate the incidence, computed tomography (CT) characteristics, and diagnostic value of the VE pattern in coronavirus disease 2019 (COVID-19).

Method: The CT data of 106 patients with COVID-19 from January 19 to February 29, 2020, and 52 patients with influenza virus pneumonia (IVP) from January 2018 to February 2020 were retrospectively collected. Read More

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January 2021

Identification of Key Genes Associated with Changes in the Host Response to Severe Burn Shock: A Bioinformatics Analysis with Data from the Gene Expression Omnibus (GEO) Database.

J Inflamm Res 2020 1;13:1029-1041. Epub 2020 Dec 1.

Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

Background: Patients with severe burns continue to display a high mortality rate during the initial shock period. The precise molecular mechanism underlying the change in host response during severe burn shock remains unknown. This study aimed to identify key genes leading to the change in host response during burn shock. Read More

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December 2020

Management of the axilla with sentinel lymph node biopsy after neoadjuvant chemotherapy for breast cancer: A single-center study.

Medicine (Baltimore) 2020 Dec;99(49):e23538

Department of Biostatistics, Faculty of Medicine, Katip Celebi University, İzmir, Turkey.

The neoadjuvant chemotherapy (NAC) is the gold standard initial treatment of the locally advanced breast cancer (LABC). However, the reliability of methods that used to assess response the NAC is still controversial. In this study, patients with LABC who underwent NAC were evaluated retrospectively. Read More

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December 2020