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A novel approach for the treatment of Morgagni hernias: robotic transabdominal preperitoneal diaphragmatic hernia repair.

Hernia 2021 Sep 7. Epub 2021 Sep 7.

Department of Surgery, Creighton University School of Graduate Medical Education, St. Joseph's Hospital, 500 W Thomas Rd Ste 400, Phoenix, AZ, USA.

Purpose: We introduce a novel approach to the surgical repair of Morgagni hernias (MHs) utilizing the robotic transabdominal preperitoneal repair (rTAPP) approach. Borrowed from our previous and robust experience with rTAPP repairs for hernias of the anterior abdominal wall, this technique boasts the benefits of hernia sac reduction, the use of an uncoated mesh in an extraperitoneal plane, and minimal fixation leading to lower postoperative pain relative to other approaches.

Methods: To evaluate the effectiveness of this novel approach, five consecutive symptomatic Morgagni hernias (MHs) were repaired with the rTAPP approach. Read More

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September 2021

An optimal feed-forward artificial neural network model and a new empirical correlation for prediction of the relative viscosity of AlO-engine oil nanofluid.

Sci Rep 2021 Aug 23;11(1):17072. Epub 2021 Aug 23.

Department of Mechanical Engineering, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr, Iran.

This study presents the design of an artificial neural network (ANN) to evaluate and predict the viscosity behavior of AlO/10W40 nanofluid at different temperatures, shear rates, and volume fraction of nanoparticles. Nanofluid viscosity ([Formula: see text]) is evaluated at volume fractions ([Formula: see text]=0.25% to 2%) and temperature range of 5 to 55 °C. Read More

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Comparison of intravenous versus topical tranexamic acid in primary total hip arthroplasty: a systematic review and meta-analysis of ten randomized trials.

J Comp Eff Res 2021 Aug 18. Epub 2021 Aug 18.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.

The optimal management approach for tranexamic acid (TXA) in primary total hip arthroplasty (THA) is still controversial. This meta-analysis aimed to evaluate the efficacy and safety of intravenous versus topical TXA during THA. PubMed, Google Scholar, Embase and the Cochrane library were searched for all randomized controlled trials comparing topical and intravenous TXA (iTXA) following primary THA. Read More

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Laser-Induced Cooperative Transition in Molecular Electronic Crystal.

Adv Mater 2021 Aug 16:e2103000. Epub 2021 Aug 16.

Department of Physics and Astronomy, Michigan State University, East Lansing, MI, 48824, USA.

The competing and non-equilibrium phase transitions, involving dynamic tunability of cooperative electronic and magnetic states in strongly correlated materials, show great promise in quantum sensing and information technology. To date, the stabilization of transient states is still in the preliminary stage, particularly with respect to molecular electronic solids. Here, a dynamic and cooperative phase in potassium-7,7,8,8-tetracyanoquinodimethane (K-TCNQ) with the control of pulsed electromagnetic excitation is demonstrated. Read More

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Ribovore: ribosomal RNA sequence analysis for GenBank submissions and database curation.

BMC Bioinformatics 2021 Aug 12;22(1):400. Epub 2021 Aug 12.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA.

Background: The DNA sequences encoding ribosomal RNA genes (rRNAs) are commonly used as markers to identify species, including in metagenomics samples that may combine many organismal communities. The 16S small subunit ribosomal RNA (SSU rRNA) gene is typically used to identify bacterial and archaeal species. The nuclear 18S SSU rRNA gene, and 28S large subunit (LSU) rRNA gene have been used as DNA barcodes and for phylogenetic studies in different eukaryote taxonomic groups. Read More

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Characterizing the Impact of Spray Dried Particle Morphology on Tablet Dissolution Using Quantitative X-Ray Microscopy.

Eur J Pharm Sci 2021 Oct 3;165:105921. Epub 2021 Jul 3.

Eli Lilly & Company, 1400 W. Raymond Street, Indianapolis, IN United States.

For oral solid dosage forms, disintegration and dissolution properties are closely related to the powders and particles used in their formulation. However, there remains a strong need to characterize the impact of particle structures on tablet compaction and performance. Three-dimensional non-invasive tomographic imaging plays an increasingly essential role in the characterization of drug substances, drug product intermediates, and drug products. Read More

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October 2021

In the landscape of SARS-CoV-2 and fresh fruits and vegetables: The fake and hidden transmission risks.

J Food Saf 2021 Mar 10:e12898. Epub 2021 Mar 10.

Department of Life Sciences The University of the West Indies Kingston Jamaica.

From the first notification reporting to the WHO a cluster of coronavirus in Wuhan City (China), over 114 million cases of SARS-CoV-2 have been confirmed, with more than 2,530,000 deaths, and over 400,000 new cases and 10,000 deaths daily. Numerous viruses are susceptible to contaminate crops during growth, harvesting, handling, marketing and minimally processing, and these steps share one common factor which is human. Different studies showed that viruses might persist on different crops for periods of 2 to 14 days under different conditions such as refrigeration, household and freezing. Read More

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A hidden web of policy influence: The pharmaceutical industry's engagement with UK's All-Party Parliamentary Groups.

PLoS One 2021 24;16(6):e0252551. Epub 2021 Jun 24.

Department of Social and Policy Sciences, University of Bath, Bath, Somerset, United Kingdom.

Our objective was to examine conflicts of interest between the UK's health-focused All-Party Parliamentary Groups (APPGs) and the pharmaceutical industry between 2012 and 2018. APPGs are informal cross-party groups revolving around a particular topic run by and for Members of the UK's Houses of Commons and Lords. They facilitate engagement between parliamentarians and external organisations, disseminate knowledge, and generate debate through meetings, publications, and events. Read More

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Opening a next-generation black box: Ecological trends for hundreds of species-like taxa uncovered within a single bacterial >99% 16S rRNA operational taxonomic unit.

Mol Ecol Resour 2021 Oct 22;21(7):2471-2485. Epub 2021 Jun 22.

Research Department for Limnology, University of Innsbruck, Mondsee, Austria.

Current knowledge on environmental distribution and taxon richness of free-living bacteria is mainly based on cultivation-independent investigations employing 16S rRNA gene sequencing methods. Yet, 16S rRNA genes are evolutionarily rather conserved, resulting in limited taxonomic and ecological resolutions provided by this marker. The faster evolving protein-encoding gene priB was used to reveal ecological patterns hidden within a single operational taxonomic unit (OTU) defined by >99% 16S rRNA sequence similarity. Read More

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October 2021

The hidden secrets of a neutral pH-blood gas analysis of postoperative patients according to the Stewart approach.

Perioper Med (Lond) 2021 Jun 8;10(1):15. Epub 2021 Jun 8.

Department of Anesthesiology, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.

Background: The superiority of either the traditional or Stewart based approach to acid-base balance has focused primarily on analyzing metabolic acidemia, with little attention given to patients with neutral pH. In this study, we evaluate metabolic disturbances in patients in the immediate postoperative period focusing on patients with neutral pH, while comparing the Stewart and traditional approach.

Methods: We conducted a single center retrospective observational cohort study. Read More

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A Hybrid Method Based on Extreme Learning Machine and Wavelet Transform Denoising for Stock Prediction.

Entropy (Basel) 2021 Apr 9;23(4). Epub 2021 Apr 9.

College of Computer Science and Technology, Harbin Institute of Technology, Shenzhen 518055, China.

The trend prediction of the stock is a main challenge. Accidental factors often lead to short-term sharp fluctuations in stock markets, deviating from the original normal trend. The short-term fluctuation of stock price has high noise, which is not conducive to the prediction of stock trends. Read More

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Impact of knowledge, attitude, and practice on iodized salt consumption at the household level in selected coastal regions of Bangladesh.

Heliyon 2021 Apr 8;7(4):e06747. Epub 2021 Apr 8.

Institute of Nutrition and Food Science, University of Dhaka, Bangladesh.

Background: Iodine deficiency disorder is one of the major hidden hunger for poverty-stricken coastal rural areas of Bangladesh. Despite various programs, including universal salt iodization, IDD is significantly persistent due to poverty, inadequate knowledge, poor attitude, and practice of iodized salt consumption. The present study aimed to determine iodine concentration in salt at the household level as well as the magnitude of knowledge, attitude, and practice related to iodized salt utilization and iodine deficiency disorders (IDDs). Read More

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Lipid-Polymer Hybrid Nanoparticles Enhance the Potency of Ampicillin against in a Protozoa Infection Model.

ACS Infect Dis 2021 06 19;7(6):1607-1618. Epub 2021 Apr 19.

Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.

() biofilms are implicated in endocarditis, urinary tract infections, and biliary tract infections. Coupled with internalization into host cells, this opportunistic pathogen poses great challenges to conventional antibiotic therapy. The inability of ampicillin (Amp) to eradicate bacteria hidden in biofilms and intracellular niches greatly reduces its efficacy against complicated infections. Read More

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[Analysis of perioperative blood loss of posterior lumbar interbody fusion on lumbar spondylolisthesis in patients with rheumatoid arthritis].

Zhonghua Yi Xue Za Zhi 2021 Mar;101(11):792-797

Department of Spinal Surgery, Heze Municipal Hospital, Heze 274000, China.

To compare the intraoperative blood loss, postoperative drainage and hidden blood loss (HBL) in lumbar posterior lumbar interbody fusion (PLIF) in patients with and without rheumatoid arthritis (RA), and analyze the relevant factors of HBL in RA patients. Fifty patients with RA (RA group) and 73 patients without RA (NRA group) treated in the Heze Municipal Hospital from January 2014 to April 2019 were enrolled in this study. The basic information, RA information, operation and related blood loss indicators in the two groups were compared. Read More

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The hidden impact of rapid spread of the COVID-19 pandemic in professional, financial, and psychosocial health of Latin American orthopedic trauma surgeons.

Injury 2021 Apr 13;52(4):673-678. Epub 2021 Mar 13.

Serviço de Ortopedia e Traumatologia Prof. Nova Monteiro, Hospital Municipal Miguel Couto, Rio de Janeiro, RJ, Brazil; Clínica São Vicente, Rede D'or São Luiz, Rio de Janeiro, RJ, Brazil; Departamento de Ortopedia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo (USP), Sao Paulo, SP, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil; Departamento de Ortopedia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Centro Universitario de Occidente, Universidad de San Carlos de Guatemala, Quetzaltenango, Guatemala; Cruz Roja Guatemalteca, Delegación Quetzaltenango, Quetzaltenango, Guatemala; Departamento de Ortopedia e Traumatologia, Universidade Federal Fluminense (UFF), Niteroi, RJ, Brazil.

Objective: To assess the quality of life of Latin American orthopedic trauma surgeons during the beginning of COVID-19 pandemic in Latin America.

Methods: A total of 400 orthopedic trauma surgeons from 14 Latin American countries were invited to complete an electronic survey aiming to understand the general situation of COVID-19 in each country and how COVID-19 had impacted life's participant financially and psychosocially. The relationship between the occurrence of the disease and the existence of legal regulations on the medical activity in the respondent's country, protocols for tracking the disease among patients hospitalized in an emergency basis due to skeletal trauma, and personal protective equipment to deal with patients diagnosed with COVID-19 who need orthopedic trauma surgery was investigated, as well as the financial and psychosocial impact caused by the disease. Read More

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[Clinical application of distal femoral patient-specific cutting guide based on knee CT and full-length X-ray film of lower extremities].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Feb;35(2):188-194

Department of Orthopedics, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu Sichuan, 610072, P.R.China.

Objective: To discuss the feasibility and accuracy of distal femoral patient-specific cutting guide in total knee arthroplasty (TKA) based on knee CT and full-length X-ray film of lower extremities.

Methods: Between July 2016 and February 2017, 20 patients with severe knee joint osteoarthritis planned to undergo primary TKA were selected as the research object. There were 9 males and 11 females; aged 53-84 years, with an average of 69. Read More

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February 2021

Differential Ion Mobility Separations of d/l Peptide Epimers.

Anal Chem 2021 03 15;93(8):4015-4022. Epub 2021 Feb 15.

Department of Chemistry, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260, United States.

Life was originally assumed to utilize the l-amino acids only. Since 1980s, the d-amino acid-containing peptides (DAACPs) were detected in animals, often at extremely low levels with tremendous functional specificity. As the unguided proteomic algorithms based on peptide masses are oblivious to DAACPs, many more are believed to be hidden in organisms and novel methods to tackle DAACPs are sought. Read More

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Physical fatigability and muscle pain in patients with Hashimoto thyroiditis.

J Neurol 2021 Jul 28;268(7):2441-2449. Epub 2021 Jan 28.

Department of Neurology, University of Halle, Saale, Germany.

Introduction: Hashimoto thyroiditis (HT) may lead to muscle weakness due to hypothyroid dysfunction. However, clinical experience treating patients with HT suggests that neuromuscular symptoms may develop in these patients despite long-standing euthyroidism.

Methods: In 24 euthyroid patients with HT and 25 healthy controls, physical fatigability was assessed using the arm movement test (AMT) and 6-min walk test (6MWT). Read More

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Co-production of an e-resource to help women who have experienced childhood sexual abuse prepare for pregnancy, birth, and parenthood.

BMC Pregnancy Childbirth 2021 Jan 7;21(1):30. Epub 2021 Jan 7.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, 57 Waterloo Road, London, SE1 8WA, UK.

Background: This paper reports the development of a co-produced e-resource to support those who have experienced childhood sexual abuse through pregnancy, birth, and parenthood. These are times of major transition for any woman but can present particular challenges for those who have experienced childhood sexual abuse. Re-traumatisation during the perinatal period is common and can occur in ways that may not be anticipated by those involved. Read More

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January 2021

Phase identification for dynamic CT enhancements with generative adversarial network.

Med Phys 2021 Mar 27;48(3):1276-1285. Epub 2021 Jan 27.

Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA.

Purpose: Dynamic contrast-enhanced computed tomography (CT) is widely used to provide dynamic tissue contrast for diagnostic investigation and vascular identification. However, the phase information of contrast injection is typically recorded manually by technicians, which introduces missing or mislabeling. Hence, imaging-based contrast phase identification is appealing, but challenging, due to large variations among different contrast protocols, vascular dynamics, and metabolism, especially for clinically acquired CT scans. Read More

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Optimal Route for Tranexamic Acid in Diabetics and Obese Patients Undergoing Primary Total Knee Arthroplasty - a Data from Randomized Study.

Acta Chir Orthop Traumatol Cech 2020 ;87(6):429-437

Department of Orthopaedics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc.

PURPOSE OF THE STUDY To determine the optimal strategy for tranexamic acid (TXA) administration in diabetic patients, smokers and obese patients (BMI > 30 kg/m2) undergoing primary total knee arthroplasty (TKA). MATERIAL AND METHODS The total of 400 consecutive patients indicated for primary TKA were randomised into 4 basic groups with different TXA administration regimens. Group 1 (IV1) had a single intravenous dose (15 mg TXA/kg) applied prior to skin incision. Read More

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January 2021

Challenges and solutions to employing natural language processing and machine learning to measure patients' health literacy and physician writing complexity: The ECLIPPSE study.

J Biomed Inform 2021 01 11;113:103658. Epub 2020 Dec 11.

University of California San Francisco Center for Vulnerable Populations, Zuckerberg San Francisco General Hospital, San Francisco, CA, United States; Department of Medicine, University of California, San Francisco, San Francisco, CA, United States; Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States.

Objective: In the National Library of Medicine funded ECLIPPSE Project (Employing Computational Linguistics to Improve Patient-Provider Secure Emails exchange), we attempted to create novel, valid, and scalable measures of both patients' health literacy (HL) and physicians' linguistic complexity by employing natural language processing (NLP) techniques and machine learning (ML). We applied these techniques to > 400,000 patients' and physicians' secure messages (SMs) exchanged via an electronic patient portal, developing and validating an automated patient literacy profile (LP) and physician complexity profile (CP). Herein, we describe the challenges faced and the solutions implemented during this innovative endeavor. Read More

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January 2021

Leprosy in a prison population: A new active search strategy and a prospective clinical analysis.

PLoS Negl Trop Dis 2020 12 10;14(12):e0008917. Epub 2020 Dec 10.

Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: This study evaluates an active search strategy for leprosy diagnosis based on responses to a Leprosy Suspicion Questionnaire (LSQ), and analyzing the clinical, immunoepidemiological and follow-up aspects for individuals living in a prison population.

Methods: A cross-sectional study based on a questionnaire posing 14 questions about leprosy symptoms and signs that was distributed to 1,400 prisoners. This was followed by dermatoneurological examination, anti-PGL-I serology and RLEP-PCR. Read More

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December 2020

Evaluation of diagnostic assay of patients with enteric fever by the box-plot distribution method.

New Microbes New Infect 2020 Nov 19;38:100795. Epub 2020 Oct 19.

Department of Microbiology, Landmark University, Nigeria.

Enteric fever is an invasive bacterial infection mostly caused by serovar Typhi, which is a common agent of enteric fever. This illness has been a major public health issue, as it affects a large number of individuals globally. The box-plot analytic method is involved in exploratory data analysis using statistical techniques to identify patterns that may be hidden in a group of numbers used to visually summarize and compare groups of data. Read More

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November 2020

Nutritional Biomarkers and Associated Factors in Community-Dwelling Older Adults: Findings from the SHIELD Study.

Nutrients 2020 Oct 29;12(11). Epub 2020 Oct 29.

Abbott Nutrition Research and Development, Asia-Pacific Center, Singapore 138668, Singapore.

Aging is associated with intrinsic and extrinsic changes which affect the nutrient intake and nutritional status of an older individual. Suboptimal nutritional status is linked with adverse health outcomes. There are limited data in this area for community-dwelling older adults who are not at risk of malnutrition. Read More

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October 2020

The outcome in patients with brain stroke: A deep learning neural network modeling.

J Res Med Sci 2020 24;25:78. Epub 2020 Aug 24.

Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: The artificial intelligence field is obtaining ever-increasing interests for enhancing the accuracy of diagnosis and the quality of patient care. Deep learning neural network (DLNN) approach was considered in patients with brain stroke (BS) to predict and classify the outcome by the risk factors.

Materials And Methods: A total of 332 patients with BS (mean age: 77. Read More

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Xylanolytic Extremozymes Retrieved From Environmental Metagenomes: Characteristics, Genetic Engineering, and Applications.

Front Microbiol 2020 17;11:551109. Epub 2020 Sep 17.

Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi, India.

Xylanolytic enzymes have extensive applications in paper, food, and feed, pharmaceutical, and biofuel industries. These industries demand xylanases that are functional under extreme conditions, such as high temperature, acidic/alkaline pH, and others, which are prevailing in bioprocessing industries. Despite the availability of several xylan-hydrolyzing enzymes from cultured microbes, there is a huge gap between what is available and what industries require. Read More

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September 2020

3D spectral fluorescence signature of cerium(III)-melamine coordination polymer: A novel sensing material for explosive detection.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jan 12;245:118941. Epub 2020 Sep 12.

Department of Biomedical Engineering, Military Technical Collage, Cairo. Egypt.

Hidden or buried explosives are the most common scenario by terrorist attacks; therefore explosive vapour detection is a vital demand. Explosives are electron deficient materials; the vicinity of explosives to fluorescent material can encounter electron migration. This study reports on facile synthesis of cerium (III)-melamine coordination polymer (CeM-CP) with exclusive optical properties. Read More

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January 2021

Detecting differential ground displacements of civil structures in fast-subsiding metropolises with interferometric SAR and band-pass filtering.

Sci Rep 2020 Sep 22;10(1):15460. Epub 2020 Sep 22.

NASA Goddard Space Flight Center, Greenbelt, MD, 20771, USA.

Ground displacements due to changes in soil conditions represent a threat to the stability of civil structures in many urban areas, worldwide. In fast-subsiding areas, regional subsidence (wavelength ~ 1,000's m) can be dominantly high and, consequently, mask other signals at local scales (wavelength ~ 10-100's m). Still, engineering and construction applications require a comprehensive knowledge of local-scale signals, which can threaten the stability of buildings and infrastructure. Read More

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September 2020

A Hidden Coordination-Bond Torsional Deformation as a Sign of Possible Spin Transition in Nickel(II)-Bis(nitroxide) Compounds.

Molecules 2020 Aug 20;25(17). Epub 2020 Aug 20.

Department of Engineering Science, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan.

Complex formation of nickel(II) tetrafluoroborate and -butyl 5-phenyl-2-pyridyl nitroxide (phpyNO) in the presence of sodium cyanate gave a discrete molecule [Ni(phpyNO)(X)] (X = NCO). The Ni-O-N-C2 torsion angles were reduced on heating; 33.5(5)° and 36. Read More

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