J Allergy Clin Immunol 2021 Apr 2. Epub 2021 Apr 2.
National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom; Immune Tolerance Network, Bethesda, MD, USA.
Introduction: There is no detailed comparison of allergen-specific immunoglobulin responses following sublingual (SLIT) and subcutaneous (SCIT) immunotherapy.
Objective: To compare nasal and systemic Timothy grass pollen (TGP)-specific antibody responses during two years of SCIT and SLIT and one year after treatment discontinuation in a double-blind, double-dummy, placebo-controlled trial.
Methods: Nasal fluid and serum were obtained yearly (per-protocol population, n=84). Read More