Nat Commun 2019 07 10;10(1):3029. Epub 2019 Jul 10.
University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering, Gainesville, FL, 32611, USA.
With improving biofabrication technology, 3D bioprinted constructs increasingly resemble real tissues. However, the fundamental principles describing how cell-generated forces within these constructs drive deformations, mechanical instabilities, and structural failures have not been established, even for basic biofabricated building blocks. Here we investigate mechanical behaviours of 3D printed microbeams made from living cells and extracellular matrix, bioprinting these simple structural elements into a 3D culture medium made from packed microgels, creating a mechanically controlled environment that allows the beams to evolve under cell-generated forces. Read More