6,679 results match your criteria 345 years


Cotrimoxazole for community-acquired urinary tract infections leads to more adverse effects than fluoroquinolones.

Infect Dis Now 2021 Jun 30;51(4):374-376. Epub 2020 Dec 30.

Infectiologie, centre hospitalier universitaire, route de Chauvel, 97139 Les Abymes, Guadeloupe, France; Faculté de médecine, université des Antilles, Fouillole, 97110 Pointe-à-Pitre, Guadeloupe, France. Electronic address:

Background: For several years, we applied an internal guideline for community-acquired urinary tract infections (cUTI), targeting the reduction of fluoroquinolone use (FQ) and thereby favouring cotrimoxazole (CTM) prescription. Our aim was to report adverse effects (AE) and outcome for patients presenting with cUTI and treated with these compounds.

Methods: This cohort study was based on the dashboard of our department, bringing together 28 parameters for all patients, including diagnosis, microbiological data, antibiotic therapy, AE, length of hospital stay (LHS) and outcome. Read More

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The experiences, attitudes and understanding of research amongst medical students at an Australian medical school.

BMC Med Educ 2021 May 10;21(1):267. Epub 2021 May 10.

School of Clinical Sciences, Monash University, Melbourne, Australia.

Background: Research engagement plays an integral role in developing clinicians that practice effective, evidence-based medicine. Research participation by clinicians, however, is declining. Given the link between research during medical school and future research output, promotion of medical student research is one avenue by which this shortage can be addressed. Read More

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Clinical and ultrasound evaluation of patients with haemophilia on prophylaxis.

Haemophilia 2021 May 10. Epub 2021 May 10.

Haemophilia Foundation of Argentina, Buenos Aires, Argentina.

Introduction: Primary prophylaxis is the current gold standard in haemophilia care for the prevention of bleeding and ensuing joint damage. Early detection of joint bleeding, whether symptomatic or subclinical, preferably during childhood, helps prevent joint deterioration and subsequent disability. The aim of this study is to evaluate the level of agreement between the Haemophilia Joint Health Score and the Haemophilia Early Arthropathy Detection with Ultrasound tools in children with severe haemophilia on primary and secondary prophylaxis. Read More

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Association of Rotavirus Vaccines With Reduction in Rotavirus Gastroenteritis in Children Younger Than 5 Years: A Systematic Review and Meta-analysis of Randomized Clinical Trials and Observational Studies.

JAMA Pediatr 2021 May 10:e210347. Epub 2021 May 10.

Department of Laboratory Medicine, the First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

Importance: Rotavirus vaccines have been introduced worldwide, and the clinical association of different rotavirus vaccines with reduction in rotavirus gastroenteritis (RVGE) after introduction are noteworthy.

Objective: To evaluate the comparative benefit, risk, and immunogenicity of different rotavirus vaccines by synthesizing randomized clinical trials (RCTs) and observational studies.

Data Sources: Relevant studies published in 4 databases: Embase, PubMed, the Cochrane Library, and Web of Science were searched until July 1, 2020, using search terms including "rotavirus" and "vaccin*. Read More

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MUSIC INTERVENTIONS IN PEDIATRIC ONCOLOGY: systematic review and meta-analysis.

Complement Ther Med 2021 May 5:102725. Epub 2021 May 5.

Pediatrics Department of the University of São Paulo, Av. Dr Enéas Carvalho Aguiar No. 647, Cerqueira Cesar, São Paulo, CEP: 05403-901, Brazil. Electronic address:

Background: Pain is a disagreeable and distressing feeling that affects human beings in multi-dimensional ways. A number of non-pharmacological interventions have had varying degrees of success in treating cancer-related pain, such as breathing and relaxation techniques, and music therapy, which have been identified as beneficial therapies for alleviating pain and anxiety.

Objective: Identify the therapeutic effects of music interventions in psychological and physiological terms and on the quality of life of children undergoing cancer treatment. Read More

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Temporomandibular-disorder-related pain as a predictor of severe headaches.

Community Dent Oral Epidemiol 2021 May 7. Epub 2021 May 7.

Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.

Objective: The current study aimed to investigate the association of temporomandibular disorders (TMD)-related pain with the presence of migraine or tension-type headaches (TTH) over a follow-up period of 11 years.

Methods: Data sets from Finnish national health surveys, the Health 2000 Survey (baseline), and the Health 2011 Survey (follow-up) were utilized. Study participants are undergoing clinical TMD examination at baseline and answering questions related to the presence of migraine and TTH at follow-up were included in the study (n = 530). Read More

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Baseline CD4 count and the time interval between the initial HIV infection and diagnosis among PLHIV in Bhutan.

Immun Inflamm Dis 2021 May 4. Epub 2021 May 4.

Department of Public Health, Ministry of Health, Thimphu, Bhutan.

Introduction: CD4 count is an important predictor of disease progression, opportunities infection, deaths, and to understand the time interval between initial HIV infection to the first diagnosis. However, baseline CD4 count and the time period between initial infection and the diagnosis amongst PLHIV in Bhutan never been evaluated.

Methods: This is a retrospective study of the diagnosed PLHIV from the existing data system from January 10 to 30, 2021. Read More

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Assessment of airway reversibility in asthmatic children using forced oscillation technique - A single-center experience from North India.

Lung India 2021 May-Jun;38(3):229-235

Department of Pediatrics, Division of Pediatric Emergency, Critical Care, Pulmonology and Allergic Disorders, Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India.

Background: Lung function testing is recommended for the management of asthma. Due to certain limitations of conventional spirometry in vulnerable patients, forced oscillation technique (FOT) has been studied with promising results. As there is a paucity of data from developing world, we planned to conduct this study in children using FOT. Read More

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Thirst distress in outpatients with heart failure in a Mediterranean zone of Spain.

ESC Heart Fail 2021 May 3. Epub 2021 May 3.

Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.

Aims: This study aimed to evaluate psychometric properties of the Spanish version of the Thirst Distress Scale for patients with Heart Failure (TDS-HF) and to describe thirst distress-associated factors in outpatients at a heart failure (HF) clinic in Spain. Thirst is common in patients with HF, but thirst distress has rarely been addressed and may significantly decrease quality of life.

Methods And Results: A cross-sectional study was performed assessing perceived thirst distress by patients with HF during the preceding 3 days, with the TDS-HF (scores 8 to 40). Read More

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Comparative Effectiveness of Lobectomy, Segmentectomy, and Wedge Resection for Pathological Stage I Non-small Cell Lung Cancer in Elderly Patients: A Population-Based Study.

Front Surg 2021 15;8:652770. Epub 2021 Apr 15.

Department of Thoracic Surgery, Peking University First Hospital, Beijing, China.

This study was designed to assess the long-term survival of lobectomy, segmentectomy, and wedge resection for pathological stage I non-small cell lung cancer (NSCLC) in patients over 75 years of age. Pathological stage I NSCLC patients aged ≥75 years who underwent lobectomy, segmentectomy, or wedge resection were identified from the Surveillance, Epidemiology, and End Results database. Propensity score-matched and competing risks analyses were conducted. Read More

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Preventable multiple high-risk birth behaviour and infant survival in Nigeria.

BMC Pregnancy Childbirth 2021 May 1;21(1):345. Epub 2021 May 1.

Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Globally, infant mortality has declined considerably but has remained unacceptably high in sub-Saharan Africa, especially Nigeria where infant mortality rate is 67/1000 live births. To facilitate infant mortality reduction in Nigeria, an understanding of the synergistic effect of bio-demographic characteristics of mothers known as High Risk Birth Behaviours (HrBBs) is important. We therefore investigated the influence of HrBBs on infant survival in Nigeria. Read More

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Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study.

Lancet Infect Dis 2021 Apr 27. Epub 2021 Apr 27.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.

Background: The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We aimed to investigate the safety and effectiveness of these vaccines in a UK community setting.

Methods: In this prospective observational study, we examined the proportion and probability of self-reported systemic and local side-effects within 8 days of vaccination in individuals using the COVID Symptom Study app who received one or two doses of the BNT162b2 vaccine or one dose of the ChAdOx1 nCoV-19 vaccine. Read More

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Association between number of teeth and Alzheimer's disease using the National Database of Health Insurance Claims and Specific Health Checkups of Japan.

PLoS One 2021 30;16(4):e0251056. Epub 2021 Apr 30.

Japan Dental Association, Tokyo, Japan.

Associations of numbers of teeth present and of missing teeth with Alzheimer's disease were cross-sectionally analyzed using the National Database of Health Insurance Claims and Specific Health Checkups of Japan. Dental care claims data of patients aged 60 years or older diagnosed with periodontitis (n = 4,009,345) or missing teeth (n = 662,182) were used to obtain information about the numbers of teeth present and of missing teeth, respectively, and they were combined with medical care claims data including the diagnosis of Alzheimer's disease. Numbers of teeth present and of missing teeth excluding third molars were calculated using the dental formula in the claims for periodontitis and missing teeth, respectively, and categorized into three groups each. Read More

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Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration after Mechanical Damage-In Vitro Study.

Int J Mol Sci 2021 Apr 24;22(9). Epub 2021 Apr 24.

Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland.

Hydroxyapatite has been used in medicine for many years as a biomaterial or a cover for other biomaterials in orthopedics and dentistry. This study characterized the physicochemical properties (structure, particle size and morphology, surface properties) of Li- and Li/Eu-doped nanohydroxyapatite obtained using the wet chemistry method. The potential regenerative properties against neurite damage in cultures of neuron-like cells (SH-SY5Y and PC12 after differentiation) were also studied. Read More

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Patterns of Alcohol Consumption in the PURE Poland Cohort Study and Their Relationship with Health Problems.

Int J Environ Res Public Health 2021 Apr 15;18(8). Epub 2021 Apr 15.

Department of Social Medicine, Wroclaw Medical University, 50-345 Wrocław, Poland.

(1) Background: Alcohol is a leading risk factor of premature morbidity and mortality. The objective of this study was to investigate the patterns of alcohol consumption in the PURE Poland cohort study baseline. (2) Methods: A Polish cohort was enrolled in the baseline study in 2007-2010. Read More

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Early Prevention of Atherosclerosis: Detection and Management of Hypercholesterolaemia in Children and Adolescents.

Life (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

Centre for Paediatric Dyslipidaemias, Paediatrics and Neonatology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, Italy.

Coronary heart disease (CHD) is the main cause of death and morbidity in the world. There is a strong evidence that the atherosclerotic process begins in childhood and that hypercholesterolaemia is a CHD major risk factor. Hypercholesterolaemia is a modifiable CHD risk factor and there is a tracking of hypercholesterolaemia from birth to adulthood. Read More

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Does the Age Affect the Outcomes of Cardiac Resynchronization Therapy in Elderly Patients?

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Department of Advanced Biomedical Sciences, Federico II University of Naples, 80138 Naples, Italy.

Background: More and more heart failure (HF) patients aged ≥ 75 years undergo cardiac resynchronization therapy (CRT) device implantation, however the data regarding the outcomes and their predictors are scant. We investigated the mid- to long-term outcomes and their predictors in CRT patients aged ≥ 75 years.

Methods: Patients in the Cardiac Resynchronization Therapy Modular (CRT MORE) Registry were divided into three age-groups: <65 (group A), 65-74 (group B) and ≥75 years (group C). Read More

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Arthroscopic Correction of Femoroacetabular Impingement for Concomitant Inguinal Disruption in Athletes With Dual Pathology.

Am J Sports Med 2021 Apr 29:3635465211007144. Epub 2021 Apr 29.

The Hip and Groin Clinic, UPMC Whitfield, Waterford, Ireland.

Background: Inguinal disruption and femoroacetabular impingement (FAI) are well-recognized sources of groin pain in athletes; however, the relationship between inguinal disruption and FAI remains unclear. In cases of dual pathology, where both entities coexist, there is no definitive consensus regarding which pathology should be prioritized for treatment in the first instance.

Purpose: (1) To examine the 2-year effectiveness and clinical outcome in athletes presenting with dual pathology in which the FAI component alone was treated with arthroscopic deformity correction. Read More

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Relationships between hormonal parameters, body fat distribution and bone mineral density in women with functional menstrual disorders.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.

Objectives: Available evidence implies that unfavorable changes in the distribution of adipose tissue resulting from hormonal imbalance associated with ovarian insufficiency might influence bone mineral density (BMD). The purpose of our study was to verify if volumes of visceral (VAT), female (FAT) and android (AAT) body fat as determined by densitometry determined influence BMD in women with functional menstrual disorders, and if these correlates some endocrine factors.

Material And Methods: We examined 293 women (mean age 26. Read More

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Utilization of Healthcare Resources in Osteoarthritis: A Cost of Illness Analysis Based on Real-World Data in Italy.

Ther Clin Risk Manag 2021 21;17:345-356. Epub 2021 Apr 21.

Real World Solutions, IQVIA Solutions Italy S.r.l., Milan, Italy.

Purpose: Understand the demographics and clinical features of patients with osteoarthritis (OA), quantify healthcare resource utilization by OA patients, and estimate the annual direct medical costs per OA patient from a National Health Service (NHS) perspective in Italy.

Patients And Methods: Retrospective observational cohort analysis using data from electronic medical records captured by the Italian IQVIA Longitudinal Patient Database (LPD). Only direct medical costs reimbursed by the NHS were considered. Read More

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Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial.

Trials 2021 Apr 28;22(1):309. Epub 2021 Apr 28.

Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Objectives: The aim of this trial is to evaluate the antiviral efficacy, clinical efficacy, and safety of nelfinavir in patients with asymptomatic and mild COVID-19.

Trial Design: The study is designed as a multicenter, open-label, blinded outcome assessment, parallel group, investigator-initiated, exploratory, randomized (1:1 ratio) controlled clinical trial.

Participants: Asymptomatic and mild COVID-19 patients will be enrolled in 10 university and teaching hospitals in Japan. Read More

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Effect of COVID-19 on childhood Mycoplasma pneumoniae infection in Chengdu, China.

BMC Pediatr 2021 04 28;21(1):202. Epub 2021 Apr 28.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), West China Second University Hospital, Ministry of Education, Sichuan University, No.20 section3 South Renmin Road, Sichuan Province, 610041, Chengdu, China.

Background: Following the outbreak of the COVID-19 pandemic, a change in the incidence and transmission of respiratory pathogens was observed. Here, we retrospectively analyzed the impact of COVID-19 on the epidemiologic characteristics of Mycoplasma pneumoniae infection among children in Chengdu, one of the largest cities of western China.

Method: M. Read More

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Characteristics of physicians working at geriatric health service facilities in Japan, 1996-2016.

PLoS One 2021 27;16(4):e0250589. Epub 2021 Apr 27.

Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: In Japan, which has the most rapidly aging population worldwide, the number of geriatric health service facilities (GHSFs) has been increasing. GHSF physicians play significant roles in integrated care for the elderly. However, little is known about the temporal trends of physicians working in GHSFs. Read More

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Transfusion requirement prediction score for patients undergoing cardiac surgery: An experience from a tertiary care set-up from South India.

Transfus Med 2021 Apr 25. Epub 2021 Apr 25.

Cardiothoracic Surgery, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

Background: Prediction of transfusion requirement is part of preoperative management in a surgical case. We aimed to develop one such tool for patients undergoing cardiac surgery.

Methods: A retrospective study for a period of 3 years was done to develop the scoring tool, Transfusion Requirement Prediction Score for Cardiac Surgery (TRPS), and internal validation was done prospectively. Read More

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Trends in ambulance transports and costs among Medicare beneficiaries, 2007-2018.

Am J Emerg Med 2021 Apr 17;47:205-212. Epub 2021 Apr 17.

General Dynamics Information Technology (GDIT), Federal Civilian Division, West Des Moines, IA, United States of America.

Background: The primary purpose of this study was to evaluate trends in ambulance utilization and costs among Medicare beneficiaries from 2007 to 2018. Community characteristics associated with ambulance use and costs are also explored.

Methods: Aggregated county-level fee-for-service (FFS) Medicare beneficiary claims data from 2007 to 2018 were used to assess ambulance transports per 1000 FFS Medicare beneficiaries and standardized inflation-adjusted ambulance costs. Read More

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Sociodemographic and Clinical Characteristics of Highly Active Antiretroviral Treatment-Naïve Human Immunodeficiency Virus-Seropositive Patients in Uyo, Nigeria: Are the Demographics Changing?

Niger Med J 2020 Nov-Dec;61(6):345-350. Epub 2020 Dec 19.

Department of Internal Medicine, University of Calabar Teaching Hospital, University of Calabar, Calabar, Cross River State, Nigeria.

Background: Human immunodeficiency virus (HIV) infection poses a great health and economic burden, especially in developing nations where a high burden of disease has been described. A previous study in Uyo shows that some characteristics associated with a higher prevalence of HIV infection include female gender, exposure to tertiary level of education, and late disease presentation. This study aimed at determining the sociodemographic and the clinical characteristics of highly active antiretroviral treatment-naïve (HAART-naïve) HIV-seropositive patients at Uyo, Nigeria. Read More

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December 2020

MeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial.

Am J Obstet Gynecol 2021 Apr 19. Epub 2021 Apr 19.

Department of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga. IBIMA; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM).

Background: Gestational diabetes not properly controlled with diet has been commonly treated with insulin. In recent years several studies have published that metformin can lead to, at least, similar obstetrical and perinatal outcomes as insulin. Nevertheless, not all clinical guidelines endorse its use, and clinical practice is heterogeneous. Read More

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Immediate versus delayed frozen embryo transfer in patients following a stimulated IVF cycle: a randomised controlled trial.

Hum Reprod 2021 Apr 22. Epub 2021 Apr 22.

Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.

Study Question: Is there any difference in the ongoing pregnancy rate after immediate versus delayed frozen embryo transfer (FET) following a stimulated IVF cycle?

Summary Answer: Immediate FET following a stimulated IVF cycle produced significantly higher ongoing pregnancy and live birth rate than did delayed FET.

What Is Known Already: Embryo cryopreservation is an increasingly important part of IVF, but there is still no good evidence to advise when to perform FET following a stimulated IVF cycle. All published studies are retrospective, and the findings are contradictory. Read More

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Nasal Septal Swell Body: A Distinctive Structure in the Nasal Cavity.

Ear Nose Throat J 2021 Apr 21:1455613211010093. Epub 2021 Apr 21.

Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China.

Objectives: The nasal septal swell body (NSB), also known as the nasal septal turbinate, is located in the anterior part of the nasal septum. This study is a narrative review of the existing knowledge on recent developments in NSB.

Methods: A literature search was performed using PubMed, Embase, Web of Science, Ovid, and Cochrane Library databases. Read More

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