269 results match your criteria 3014 patients


Randomized Placebo-Controlled Trial of Ferric Carboxymaltose in Heart Failure With Iron Deficiency: Rationale and Design.

Circ Heart Fail 2021 May 18;14(5):e008100. Epub 2021 May 18.

Duke Clinical Research Institute, Durham, NC (R.J.M., F.R., J.G., M.D.S., D.L., A.F.H.).

Background: Iron deficiency (ID) has a prevalence of ≈40% to 50% among patients in heart failure (HF) with reduced ejection fraction and is associated with worse prognosis. Several trials demonstrated that intravenous ferric carboxymaltose leads to early and sustained improvement in patient-reported outcomes and functional capacity in patients with HF with reduced ejection fraction with ID, yet morbidity and mortality data are limited.

Methods: The objective of the HEART-FID trial (Ferric Carboxymaltose in Heart Failure With Iron Deficiency) is to assess efficacy and safety of ferric carboxymaltose compared with placebo as treatment for symptomatic HF with reduced ejection fraction with ID. Read More

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Updated Kimura-Takemoto classification of atrophic gastritis.

World J Clin Cases 2021 May;9(13):3014-3023

Department of Pathological Anatomy, Stavropol State Medical University, Stavropol 355017, Russia.

Background: The Updated Sydney system for visual evaluation of gastric mucosal atrophy endoscopic observation is subject to sampling error and interobserver variability. The Kimura-Takemoto classification system was developed to overcome these limitations.

Aim: To compare the morphological classification of atrophic gastritis between the Kimura-Takemoto system and the Updated Sydney system. Read More

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Embryo biopsy and maternal and neonatal outcomes following cryopreserved-thawed single embryo transfer.

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Background: Contemporary embryo biopsy in the United States involves the removal of several cells from a blastocyst that would become the placenta for preimplantation genetic testing. Embryos are then cryopreserved while patients await biopsy results, with transfers occurring in a subsequent cycle as a single frozen-thawed embryo transfer, if euploid.

Objective: We sought to determine if removal of these cells for preimplantation genetic testing was associated with adverse obstetrical or neonatal outcomes after frozen-thawed single embryo transfer. Read More

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Thirty-Day Unplanned Readmission After Ambulatory Laparoscopic Cholecystectomy in Western China: A Retrospective Study.

Cureus 2021 Mar 16;13(3):e13932. Epub 2021 Mar 16.

Day Surgery Center, West China Hospital, Sichuan University, Chengdu, CHN.

Background Day surgery has been gradually accepted by health professions globally, which can shorten the hospital stay and reduce medical costs. The ambulatory laparoscopic cholecystectomy (LC) has been performed in China since over 10 years. However, few studies focus on its 30-day unplanned readmission rate of ambulatory LC and no standard of unplanned readmission rate for that now. Read More

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Robotic and laparoscopic sacrocolpopexy for pelvic organ prolapse: a systematic review and meta-analysis.

Ann Transl Med 2021 Mar;9(6):449

Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Sacrocolpopexy is the gold standard procedure for treating pelvic organ prolapse (POP) patients with apical defects. Different surgical approaches have emerged and been utilized successively, including traditional laparoscopy, single-hole laparoscopy, robotic laparoscopy, vaginal-assisted laparoscopy, and transvaginal approaches. Robotic sacrocolpopexy (RSC) has attracted increasing attention as an emerging surgical technique and has unique advantages, such as a "simulated wrist" mechanical arm and high-definition three-dimensional (3D) visual field, which has gradually begun to be utilized in the clinical setting. Read More

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Enablers and Barriers to Accessing Healthcare Services for Aboriginal People in New South Wales, Australia.

Int J Environ Res Public Health 2021 03 15;18(6). Epub 2021 Mar 15.

The Poche Centre for Indigenous Health, Faculty of Medicine and Health, Edward Ford Building A27, The University of Sydney, Camperdown, NSW 2006, Australia.

Background: Australia's healthcare system is complex and fragmented which can create challenges in healthcare, particularly in rural and remote areas. Aboriginal people experience inequalities in healthcare treatment and outcomes. This study aimed to investigate barriers and enablers to accessing healthcare services for Aboriginal people living in regional and remote Australia. Read More

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Automatic external defibrillator provided by unmanned aerial vehicle (drone) in Greater Paris: A real world-based simulation.

Resuscitation 2021 May 22;162:259-265. Epub 2021 Mar 22.

Emergency Medical Department, Paris Fire Brigade, 1, Place Jules Renard, 75017 Paris, France.

Aim: To reduce the delay in defibrillation of out-of-hospital cardiac arrest (OHCA) patients, recent publications have shown that drones equipped with an automatic external defibrillator (AED) appear to be effective in sparsely populated areas. To study the effectiveness of AED-drones in high-density urban areas, we developed an algorithm based on emergency dispatch parameters for the rate and detection speed of cardiac arrests and technical and meteorological parameters.

Methods: We ran a numerical simulation to compare the actual time required by the Basic Life Support team (BLSt) for OHCA patients in Greater Paris in 2017 to the time required by an AED-drone. Read More

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Design of proxy indicators estimating the appropriateness of antibiotics prescribed by French dentists: a cross-sectional study based on reimbursement data.

Antimicrob Agents Chemother 2021 Mar 8. Epub 2021 Mar 8.

Université de Lorraine, APEMAC, Nancy, France.

- The literature shows that the prescription of antibiotics in dental care is often unnecessary or inappropriate. Indicators estimating the appropriateness of antibiotics prescribed by dentists based on routine databases are however not available in the literature. Our objectives were to: (i) design proxy indicators estimating the appropriateness of antibiotics prescribed by dentists; (ii) evaluate their clinimetric properties; and (iii) provide results for these proxy indicators for dentists located in a north-eastern French region. Read More

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[Prevalence and risk factors associated with intradialytic hypotension in Sub-Saharan Africa: The case of Burkina Faso].

Ann Cardiol Angeiol (Paris) 2021 Feb 23. Epub 2021 Feb 23.

Service de néphrologie, centre hospitalier universitaire Yalgado Ouedraogo, Ouagadougou, Burkina Faso.

Aim: The aim of our study was to determine the prevalence and factors associated with intradialytic hypotension in our cohort of chronic hemodialysis patients.

Methods: This was a prospective monocentric study over a six-month period. Intradialytic hypotension was defined as a decrease in systolic blood pressure ≥ 20mmHg or a decrease in mean arterial pressure of 10mmHg associated with clinical events and the need for nursing interventions. Read More

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February 2021

Transfusion profile, clinical characteristics, comorbidities and outcomes of 3014 hospitalized patients diagnosed with COVID-19 in Brazil.

Vox Sang 2021 Feb 26. Epub 2021 Feb 26.

Grupo Gestor de Serviços de Hemoterapia - Grupo GSH, Sao Paulo, Brazil.

Background: The novel coronavirus disease-2019 (COVID-19) caused a sudden and unexpected increase in the number of hospital admissions and deaths worldwide. The impact of social distancing on blood stocks was significant. Data on the use of blood products by patients with COVID-19 are scarce. Read More

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February 2021

Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice.

Sci Rep 2021 Feb 4;11(1):3014. Epub 2021 Feb 4.

School of Pharmacy, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

In calcific aortic valve disease (CAVD) progressive valvular calcification causes aortic valve dysfunction. CAVD has several risk factors such as age and dyslipidemia. Vitamin K was shown to inhibit vascular calcification in mice and valvular calcification in patients with CAVD. Read More

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February 2021

Diagnostic management of inpatients with a positive D-dimer test: developing a new clinical decision-making rule for pulmonary embolism.

Pulm Circ 2021 Jan-Mar;11(1):2045894020943378. Epub 2021 Jan 7.

Department of Respiratory medicine, The Second Clinical Hospital of Chongqing Medical University, Chongqing, China.

Background: A positive D-dimer test has high sensitivity but relatively poor specificity for the diagnosis of pulmonary embolism, causing difficulty for clinicians unskilled in pulmonary embolism diagnosis in determining whether a patient with a positive D-dimer test needs to undergo computed tomographic pulmonary angiography.

Objectives: We sought to develop a new clinical decision-making rule based on a positive D-dimer result to predict the probability of pulmonary embolism and to guide clinicians in making decisions regarding the need for computed tomographic pulmonary angiography.

Methods: We conducted a prospective, multicenter study in three hospitals in China. Read More

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January 2021

Safety and Tolerability of Subcutaneous IgPro20 at High Infusion Parameters in Patients with Primary Immunodeficiency: Findings from the Pump-Assisted Administration Cohorts of the HILO Study.

J Clin Immunol 2021 Feb 6;41(2):458-469. Epub 2021 Jan 6.

CSL Behring LLC, 1020 First Avenue, King of Prussia, PA, 19406, USA.

Purpose: To evaluate the safety and tolerability of subcutaneous IgPro20 (Hizentra, CSL Behring, King of Prussia, PA, USA) administered at high infusion parameters (> 25 mL and > 25 mL/h per injection site) in patients with primary immunodeficiency.

Methods: The Hizentra Label Optimization (HILO) study was an open-label, parallel-arm, non-randomized study (NCT03033745) of IgPro20 using a forced upward titration design for infusion parameters. Patients experienced with pump-assisted IgPro20 infusions received weekly IgPro20 infusions at a stable dose in the Pump-Assisted Volume Cohort (N = 15; 25-50 mL per injection site) and in the Pump-Assisted Flow Rate Cohort (N = 18; 25-100 mL/h per injection site). Read More

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February 2021

Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study.

J Clin Immunol 2021 Jan 6;41(1):66-75. Epub 2020 Oct 6.

CSL Behring LLC, 1020 First Avenue, King of Prussia, PA, 19406, USA.

Purpose: To evaluate the safety and tolerability of IgPro20 manual push (also known as rapid push) infusions at flow rates of 0.5-2.0 mL/min. Read More

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January 2021

IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators.

J Immunol 2020 11 2;205(10):2640-2648. Epub 2020 Oct 2.

Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland;

IVIG preparations consisting of pooled IgG are increasingly used for the treatment of autoimmune diseases. IVIG is known to regulate the viability of immune cells, including neutrophils. We report that plasma-derived IgA efficiently triggers death of neutrophils primed by cytokines or TLR agonists. Read More

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November 2020

PPP1R21-related syndromic intellectual disability: Report of an adult patient and review.

Am J Med Genet A 2020 12 27;182(12):3014-3022. Epub 2020 Sep 27.

Scientific Directorate, Bambino Gesù Pediatric Hospital, IRCCS, Rome, Italy.

Variants in PPP1R21 were recently found to be associated with an autosomal recessive intellectual disability syndrome in 9 individuals. Our patient, the oldest among the known subjects affected by PPP1R21-related syndrome, manifested intellectual disability, short stature, congenital ataxia with cerebellar vermis hypoplasia, generalized hypertrichosis, ulcerative keratitis, muscle weakness, progressive coarse appearance, macroglossia with fissured tongue, and deep palmar and plantar creases. We provide an overview of the clinical spectrum and natural history of this newly recognized disorder, arguing the emerging notion that PPP1R21 gene mutations could result in endolysosomal functional defects. Read More

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December 2020

Prevalence and factors associated with false hyperkalaemia in Asians in primary care: a cross-sectional study (the Unlysed Hyperkalaemia- the Unseen Burden (UHUB) study).

BMJ Open 2020 09 22;10(9):e033755. Epub 2020 Sep 22.

Research, SingHealth Polyclinics, Singapore.

Serum potassium is part of routine laboratory tests done for patients with hypertension or diabetes mellitus in primary care. Those found to have raised potassium (K>5.5 mmol/L) are recalled for repeat potassium in emergency departments or primary care clinics. Read More

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September 2020

Automatic detection of non-perfusion areas in diabetic macular edema from fundus fluorescein angiography for decision making using deep learning.

Sci Rep 2020 09 15;10(1):15138. Epub 2020 Sep 15.

Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.

Vision loss caused by diabetic macular edema (DME) can be prevented by early detection and laser photocoagulation. As there is no comprehensive detection technique to recognize NPA, we proposed an automatic detection method of NPA on fundus fluorescein angiography (FFA) in DME. The study included 3,014 FFA images of 221 patients with DME. Read More

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September 2020

A pairwise meta-analytic comparison of aortic valve area determined by planimetric versus hemodynamic methods in aortic stenosis.

Int J Cardiol 2021 01 9;322:77-85. Epub 2020 Sep 9.

Department of Cardiothoracic Surgery, Weill Cornell Medicine/New York Presbyterian, New York, NY, USA.

Background: Aortic valve area (AVA) is commonly determined from 2-dimensional transthoracic echocardiography (2D TTE) by the continuity equation; however, this method relies on geometric assumptions of the left ventricular outflow tract which may not hold true. This study compared mean differences and correlations for AVA by planimetric (2-dimensional transesophageal echocardiography [2D TEE], 3-dimensional transesophageal echocardiography [3D TEE], 3-dimensional transthoracic echocardiography [3D TTE], multi-detector computed tomography [MDCT], and magnetic resonance imaging [MRI]) with hemodynamic methods (2D TTE and catheterization) using pairwise meta-analysis.

Method: Ovid MEDLINE®, Ovid EMBASE, and The Cochrane Library (Wiley) were queried for studies comparing AVA measurements assessed by planimetric and hemodynamic techniques. Read More

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January 2021

Perceptions of optimal end-of-life care in hospitals: A cross-sectional study of nurses in three locations.

J Adv Nurs 2020 Nov 4;76(11):3014-3025. Epub 2020 Sep 4.

Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.

Aim: To examine whether nurses' location of employment, demographics, or training influences their perceptions of what constitutes optimal care for dying patients in hospital.

Design: Questionnaire-based, cross-sectional study.

Methods: Between December 2016-June 2018, 582 registered or enrolled nurses from Australia (N = 153), South Korea (N = 241), and Hong Kong (N = 188) employed in a variety of hospital care units rated the extent to which they agreed with 29 indicators of optimal end-of-life care across four domains: patient, family, healthcare team, and healthcare system. Read More

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November 2020

Cost of care for the initial management of cervical cancer in women with commercial insurance.

Am J Obstet Gynecol 2021 03 17;224(3):286.e1-286.e11. Epub 2020 Aug 17.

Columbia University College of Physicians and Surgeons, New York, NY; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY; NewYork-Presbyterian Hospital, New York, NY. Electronic address:

Background: Women with newly diagnosed cervical cancer are often treated with extensive, multimodal therapies that may include a combination of surgery, radiation, and chemotherapy. Little is known about the cost of treatment or how these costs are passed on to the patients.

Objective: The objectives of this study were to examine the cost of care during the first year after a diagnosis of cervical cancer, to estimate the sources of the costs, and to explore the out-of-pocket costs. Read More

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Combined deepening trochleoplasty and supracondylar external rotation osteotomy for recurrent patellar instability in patients with trochlear dysplasia and increased femoral antetorsion.

Authors:
Roland M Biedert

Knee 2020 Aug 27;27(4):1158-1166. Epub 2020 Jun 27.

Department of Orthopaedic Surgery & Sports Traumatology, SportsClinic#1, Wankdorf Center, Papiermühlestrasse 73, CH-3014 Bern, Switzerland. Electronic address:

Background: Deepening trochleoplasty has become a part of surgical management in patients with patellar instability and severe trochlear dysplasia. In addition, increased femoral antetorsion is treated most commonly by proximal femoral external rotation osteotomy.

Hypothesis: Deepening trochleoplasty and supracondylar femoral external rotation osteotomy in combination improve patellar stability and function in patients presenting with recurrent patellar instability due to trochlear dysplasia and increased femoral antetorsion. Read More

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ASTRIS, a large real-world study to evaluate the efficacy of osimertinib in epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer patients: Clinical characteristics and genotyping methods in a Spanish cohort.

Rev Esp Patol 2020 Jul - Sep;53(3):140-148. Epub 2020 Jan 13.

Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain. Electronic address:

Purpose: Osimertinib has proven efficacy in EGFR T790M mutation-positive non-small cell lung cancer (NSCLC) patients; however, its benefits have not been evaluated in a real-world setting.

Methods: ASTRIS is a single-arm, open-label, multinational study to evaluate the efficacy and safety of osimertinib for the treatment of EGFR T790M mutation-positive NSCLC. We present the study design and preliminary cut-off analysis results (as of October 2017) describing the baseline characteristics and methodology for T790M mutation detection in the Spanish cohort. Read More

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January 2020

The impact of laparoscopic technique on the rate of perineal hernia after abdominoperineal resection of the rectum.

Surg Endosc 2021 Jun 22;35(6):3014-3024. Epub 2020 Jun 22.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

Aim: To determine the impact of surgical technique on the incidence of perineal hernia after abdominoperineal resection (APR).

Methods: A retrospective analysis was performed on patients who underwent APR between May 2007 and March 2018 at our institution using our prospectively maintained Colorectal Cancer Database. Demographic and clinical parameters were compared between the open APR (OAPR) and laparoscopic APR (LAPR) groups using Student's t test, chi-squared, or Fisher's exact test. Read More

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Antipsychotic-like effects of a novel phosphodiesterase 10A inhibitor MT-3014 in rats.

Pharmacol Biochem Behav 2020 09 18;196:172972. Epub 2020 Jun 18.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan.

Phosphodiesterase (PDE) 10A is an attractive therapeutic target for schizophrenia. Here, we investigated the antipsychotic-like effects of a novel PDE10A inhibitor, 1-({2-(7-fluoro-3-methylquinoxalin-2-yl)-5-[(3R)-3-fluoropyrrolidin-1-yl]pyrazolo[1,5-α]pyrimidin-7-yl}amino)-2-methylpropan-2-ol hydrochloride (MT-3014) in rats. MT-3014 showed a potent and selective inhibitory effect against PDE10A (IC = 0. Read More

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September 2020

Caring for older cancer patients: A scoping review.

Health Policy 2020 09 29;124(9):1008-1016. Epub 2020 May 29.

Desautels Faculty of Management, McGill University, 1001 Sherbrooke Street West, Montreal, Quebec, H3A 1G5, Canada.

There is a growing recognition among oncologists that older patients differ from other cancer patients. Older patients present age-specific issues affecting the prevention and management of their cancer. Over the years, this has led to the development of the discipline of geriatric oncology, which is the set of practices elaborated to evaluate, treat, follow-up and rehabilitate the population of older cancer patients. Read More

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September 2020

Meta-analysis of prepectoral implant-based breast reconstruction: guide to patient selection and current outcomes.

Breast Cancer Res Treat 2020 Aug 9;182(3):543-554. Epub 2020 Jun 9.

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, USA.

Purpose:  This meta-analysis provides a large-scale comparison of prepectoral vs. subpectoral implant-based breast reconstruction, with primary outcomes of patient safety and efficacy.

Methods: Literature review was performed via PRISMA criteria, 33 studies met inclusion criteria for prepectoral review and 13 studies met inclusion criteria for meta-analysis. Read More

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The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion.

Mol Neurobiol 2020 Jul 26;57(7):3014-3026. Epub 2020 May 26.

I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, Russia, 119991.

Oxidative stress associated with chronic cerebral hypoperfusion is one of the fundamental factors leading to neurodegenerative diseases. To prevent oxidative stress, physical activity is effective. Physical exercise enables development of rehabilitation techniques that can progressively increase patients' stress resistance. Read More

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Radical Resection Versus Simple Cholecystectomy for Gallbladder Carcinoma: A Systematic Review and Meta-analysis.

Surg Laparosc Endosc Percutan Tech 2020 Aug;30(4):381-387

Breast Surgery, Gansu Wuwei Academy of Medical Science, Wuwei, Gansu Province, China.

Purpose: The goal of this study was to review relevant randomized controlled trials or case-control studies to determine radical resection compared with simple cholecystectomy for gallbladder carcinoma.

Methods: Using appropriate keywords, we identified relevant studies using PubMed, the Cochrane Library, and Embase. Key pertinent sources in the literature were also reviewed, and all articles published through September 2019 were considered for inclusion. Read More

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