27,984 results match your criteria 30-day mortality


The place in therapy of ceftazidime/avibactam and ceftolozane/tazobactam in hematological patients with febrile neutropenia.

Int J Antimicrob Agents 2021 Apr 7:106335. Epub 2021 Apr 7.

Clinic of Infectious Diseases, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.

Objectives: We evaluate ceftazidime/avibactam (C/A) and ceftolozane/tazobactam (C/T) use in hematological patients with febrile neutropenia (FN) receiving high-dose chemotherapy and HSCT.

Methods: Between January-December 2018, we conducted a retrospective study to assess C/A and C/T efficacy through infection-related mortality (IRM) and bacteremia clearance for carbapenem-resistant Gram-negative bacteria (CR-GNB) pre-engraftment blood-stream infections (PE-BSIs).

Results: Seventy patients underwent allogeneic HSCT: C/A and C/T were dispensed in 13% and 3%, respectively. Read More

View Article and Full-Text PDF

Results of a hospitalization policy of asymptomatic and pre-symptomatic COVID-19-positive long-term care facility residents in the province of Salzburg-a report from the AGMT COVID-19 Registry.

Geroscience 2021 Apr 10. Epub 2021 Apr 10.

Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.

COVID-19-associated case fatality rates up to 48% were reported among nursing facility residents. During the first wave of the COVID-19 pandemic, routine SARS-CoV-2 testing in long-term care facilities in the Province of Salzburg and centralized hospitalization in the COVID-19 unit of the Paracelsus Medical University Salzburg (Austria) irrespective of symptoms was implemented. Baseline characteristics and the course of COVID-19 disease were assessed among hospitalized long-term care facility residents within the COVID-19 Registry of the Austrian Group Medical Tumor Therapy (AGMT; NCT04351529). Read More

View Article and Full-Text PDF

Comparisons of postoperative outcomes after breast cancer surgery in patients with and without renal replacement therapy: a matched-pair cohort study using a Japanese nationwide inpatient database.

Breast Cancer 2021 Apr 10. Epub 2021 Apr 10.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Although patients receiving renal replacement therapy (RRT) have more comorbidities and higher mortality and morbidity risks than the general population, surgery during breast cancer treatment is crucial because of limitations in anticancer agents for patients with renal insufficiency. We aimed to compare the short-term postoperative outcomes between patients with and without RRT.

Methods: Patients who underwent surgery for stages 0-III breast cancer between July 2010 and March 2017 were retrospectively identified in a Japanese nationwide inpatient database and divided into those with RRT (RRT group, n = 1547) and those without RRT (control group, n = 364,047). Read More

View Article and Full-Text PDF

Unsupervised phenotyping of sepsis using nonnegative matrix factorization of temporal trends from a multivariate panel of physiological measurements.

BMC Med Inform Decis Mak 2021 Apr 9;21(Suppl 5):95. Epub 2021 Apr 9.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Background: Sepsis is a highly lethal and heterogeneous disease. Utilization of an unsupervised method may identify novel clinical phenotypes that lead to targeted therapies and improved care.

Methods: Our objective was to derive clinically relevant sepsis phenotypes from a multivariate panel of physiological data using subgraph-augmented nonnegative matrix factorization. Read More

View Article and Full-Text PDF

Restarting cataract surgery during the COVID-19 pandemic; a prospective study analysing 30 day outcomes after elective cataract surgery in the United Kingdom.

BMC Ophthalmol 2021 Apr 9;21(1):167. Epub 2021 Apr 9.

Ophthalmology Department, Ashford & St Peter's Hospitals NHS Foundation Trust, Ashford, UK.

Background: Cataract is a significant cause of preventable blindness in the United Kingdom and worldwide. Prior to the COVID-19 pandemic, cataract surgery was the most commonly performed operation by the National Health Service in the United Kingdom. The aim of this study is to evaluate the safety of elective cataract surgery performed in the United Kingdom in a COVID-19 free hospital during the COVID-19 pandemic. Read More

View Article and Full-Text PDF

The Administrative Risk Analysis Index (RAI-A) Does Not Predict Reintervention or Mortality Within 30 Days in Patients Who Undergo Elective Open or Endovascular Abdominal Aortic Aneurysm Repair.

Authors:
Jeanette Man Jun Xu

J Surg Res 2021 Apr 6;264:179-185. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular Surgery, University of Iowa, Iowa City, Iowa. Electronic address:

Objective: Frailty scores are increasingly utilized to predict postoperative complications. The purpose of this study is to determine whether the administrative risk analysis index (RAI-A) can be used to predict reintervention or mortality within 30 days in patients who undergo elective open or endovascular abdominal aortic aneurysm (AAA) repair.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was used to query data from elective open or endovascular aortic aneurysm repairs from 2011 to 2018. Read More

View Article and Full-Text PDF

A National Assessment of Optimal Oncologic Surgery for Distal Pancreatic Adenocarcinomas.

Pancreas 2021 Mar;50(3):386-392

From the Division of Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center Cancer Pavilion, Pittsburgh, PA.

Objectives: The objective of this study was to create a composite measure, optimal oncologic surgery (OOS), for patients undergoing distal pancreatectomy for pancreatic adenocarcinoma and identify factors associated with OOS.

Methods: Adult patients undergoing distal pancreatectomy were identified from the National Cancer Database between 2010 and 2016. Patients were stratified based on receipt of OOS. Read More

View Article and Full-Text PDF

MORTALITY SCORES IN SURGICAL CORRECTION OF ABDOMINAL AORTIC ANEURYSM IN RUPTURE.

Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):39-44. Epub 2021 Apr 8.

Hospital da Senhora da Oliveira de Guimarães, EPE, Portugal.

Introduction: Ruptured abdominal aortic aneurysm's treatment relies on the emergent surgery, considering preoperative prognosis. There are several scores that estimate perioperative mortality of ruptured abdominal aortic aneurysm, however, the accuracy of such algorithms in some populations remains unknown.

Objective: Compare the prognostic validity of the Weingarten score with the Glasgow Aneurysm Score and the Vancouver Scoring System. Read More

View Article and Full-Text PDF

Increased number of ventricular septal rupture cases after acute myocardial infarction in 2020.

J Card Surg 2021 Apr 8. Epub 2021 Apr 8.

Cardiac Surgery Department, INCOR - Heart Institute, University of Sao Paulo, São Paulo, SP, Brazil.

Introduction: Ventricular septal rupture (VSR) is a serious mechanical complication after acute coronary syndrome and is related to high mortality. Even with advances in the management of acute myocardial infarction (AMI) such as reperfusion therapies, complication rates are still high. During quarantine, patients presenting mechanical complications after AMI have increased in our institution. Read More

View Article and Full-Text PDF

Mortality rates and risk factors after low-trauma hip fracture in the largest university center in Romania.

Arch Osteoporos 2021 Apr 8;16(1):64. Epub 2021 Apr 8.

Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, 34-38 Aviatorilor blvd, 011863, Bucharest, Romania.

We calculated in-hospital, 30-day, and 1-year mortality rates and analyzed potential mortality risk factors in 2742 patients with low-trauma hip fractures. We found a high mortality rate at 30 days and 1 year after hip fracture. The high mortality can be explained by a very high number of conservatively treated fractures. Read More

View Article and Full-Text PDF

Spinal surgery during the COVID-19 pandemic: the experience in a tertiary referral centre.

J Spine Surg 2021 Mar;7(1):62-67

Department of Spinal Surgery, Salford Royal NHS Foundation Trust, Salford, UK.

Background: The COVID-19 pandemic first came to prominence in December 2019, and since then has swept the globe, causing one of the largest public health problems seen. It has had a wide-ranging impact on healthcare provision, with a cessation of elective operating. We aimed to assess the impact of COVID-19 on a tertiary referral centre for spinal surgery in England. Read More

View Article and Full-Text PDF

Latin-American Registry of Cardiovascular Disease and COVID-19: Rationale and Design of the CARDIO COVID 19-20 Registry.

Glob Heart 2021 Feb 12;16(1):14. Epub 2021 Feb 12.

Servicios y Tecnología Cardiovascular de Guatemala S.A, GT.

Background: Infection caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) exhibits a strong infectivity but less virulence compared to severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS). In terms of cardiovascular morbidity, susceptible population include elderly and patients with certain cardiovascular conditions. This infection has been associated with cardiac injury, cardiovascular complications and higher mortality. Read More

View Article and Full-Text PDF
February 2021

Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19.

Cureus 2021 Mar 4;13(3):e13687. Epub 2021 Mar 4.

Infectious Diseases Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova De Gaia, PRT.

Introduction Since the declaration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in March 2020, Portugal was considered a role model with regards to the first COVID-19 wave. However, a third wave started in 2021 started, turning the country into the worst in the world regarding new infections and death rate per capita in the last weeks of January 2021. No significant data regarding the country's first wave of hospitalized patients have been published. Read More

View Article and Full-Text PDF

C-Reactive Protein-to-Albumin Ratio Predicts Sepsis and Prognosis in Patients with Severe Burn Injury.

Mediators Inflamm 2021 24;2021:6621101. Epub 2021 Mar 24.

Department of Plastic and Burn Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41 Xibei Road, Haishu District, Ningbo City, 315000 Zhejiang Province, China.

Background: Sepsis is a leading cause of mortality among severe burns. This study was conducted to investigate the predictive role of C-reactive protein-to-albumin ratio (CAR) for sepsis and prognosis in severe burns.

Methods: Patients with severe burn injuries from 2013 to 2017 were enrolled and divided into septic and nonseptic groups based on the presence of sepsis within 30 days postburn. Read More

View Article and Full-Text PDF

Prospective multicenter study on the incidence of surgical site infection after emergency abdominal surgery in China.

Sci Rep 2021 Apr 8;11(1):7794. Epub 2021 Apr 8.

Department of Emergency Medicine, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266000, People's Republic of China.

There is still a lack of relevant studies on surgical site infection (SSI) after emergency abdominal surgery (EAS) in China. This study aims to understand the incidence of SSI after EAS in China and discuss its risk factors. All adult patients who underwent EAS in 47 hospitals in China from May 1 to 31, 2018, and from May 1 to June 7, 2019, were enrolled in this study. Read More

View Article and Full-Text PDF

Impact of obesity on influenza compared to pneumonia hospitalization outcomes.

Obes Res Clin Pract 2021 Apr 5. Epub 2021 Apr 5.

Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objectives: Previous literature has suggested that obesity impacts mortality risk differently in bacterial versus viral infections. This study sought to further elucidate this association in pneumonia versus influenza.

Design: Retrospective cohort study. Read More

View Article and Full-Text PDF

[Surgical Strategy for Aortic Arch Aneurysm Depending on the Patient's Condition:Proper Selection of Open Surgery or Thoracic Endovascular Repair].

Kyobu Geka 2021 Apr;74(4):271-280

Department of Cardiovascular Surgery, Teine Keijinkai Hospital, Sapporo, Japan.

Objectives: We investigated the validity of the surgical strategy for aortic arch aneurysm depending on the patient's condition.

Methods: Between 2014 and 2019, 70 patients underwent total arch replacement (TAR) and 14 patients underwent fenestrated thoracic endovascular aortic repair( fTEVAR) for aortic arch aneurysm. We selected the surgical strategy on the basis of the patient's condition with or without frailty and if surgical risks including cancer or a respiratory condition precluded open surgery. Read More

View Article and Full-Text PDF

[The Mid-term Results of Transapical Transcatheter Aortic Valve Implantation for Aortic Stenosis].

Kyobu Geka 2021 Mar;74(3):174-180

Department of Cardiovascular Surgery, Fukuyama Cardiovascular Hospital, Fukuyama, Japan.

We aimed to evaluate the results of transapical transcatheter aortic valve implantation (TAVI) for aortic stenosis. Thirty patients who had aortic stenosis and underwent transapical TAVI between 2016 and 2020 were enrolled. Medical records were reviewed, and the following data were retrieved and analyzed:basic demographic data, and intraoperative data and postoperative outcomes. Read More

View Article and Full-Text PDF

Lower socioeconomic factors are associated with higher mortality in patients with septic shock.

Heart Lung 2021 Apr 5;50(4):477-480. Epub 2021 Apr 5.

Department of Pharmacy, Loyola University Medical Center USA; Department of Emergency Medicine, Loyola University Medical Center USA.

Background: Previous studies have explored the relationship between socioeconomic status and sepsis outcomes OBJECTIVES: The purpose of this investigation is to determine if race, ethnicity, economic stability, neighborhood environment, and access to health care are predictive of mortality in patients with septic shock.

Methods: Retrospective study of septic shock patients admitted to two medical centers.

Results: Caucasian patients had higher proportion of outpatient physician visits in the year prior to admission and were less likely to be Medicare or Medicaid beneficiaries. Read More

View Article and Full-Text PDF

Fenestrated Endovascular Aneurysm Repair Affords Fewer Renal Complications Than Open Surgical Repair for Juxtarenal Abdominal Aortic Aneurysms in Patients with Chronic Renal Insufficiency.

Ann Vasc Surg 2021 Apr 5. Epub 2021 Apr 5.

The George Washington University Department of Surgery, Washington, District of Columbia.

Type Of Research: Retrospective NSQIP database review KEY FINDINGS:: Comparison of FEVAR vs OSR for juxtarenal abdominal aortic aneurysms in patients with renal disease showed similar 30-day mortality. However, FEVAR was associated with fewer renal and pulmonary complications compared to OSR.

Take Home Message: FEVAR is better for patients with chronic renal insufficiency due to decreased renal and pulmonary complications. Read More

View Article and Full-Text PDF

Beating vs Arrested Heart Isolated Tricuspid Valve Surgery: Long-term Outcomes.

Ann Thorac Surg 2021 Apr 5. Epub 2021 Apr 5.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Background: Isolated tricuspid valve (TV) surgery is a rare procedure generally considered at high risk of perioperative mortality and poor long-term outcomes. Surgical treatment can be performed with either an arrested heart (AH) or beating heart (BH) technique. Aim of this study is to compare the outcomes of isolated tricuspid surgery with two different approaches. Read More

View Article and Full-Text PDF

Early commercial experience with a newly designed balloon-expandable transcatheter heart valve: 30-day outcomes and implications of preprocedural computed tomography.

Interact Cardiovasc Thorac Surg 2021 Apr;32(3):426-432

Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.

Objectives: We herein report a single-centre experience with the SAPIEN 3 Ultra balloon-expandable transcatheter aortic valve implantation (TAVI) system.

Methods: Between March 2019 and January 2020, a total of 79 consecutive patients received transfemoral TAVI using the SAPIEN 3 Ultra device. Data were retrospectively analysed according to updated Valve Academic Research Consortium-2 definitions. Read More

View Article and Full-Text PDF

Multicenter comparison of high-dose cytarabine-based regimens versus liposomal daunorubicin and cytarabine (CPX-351) in patients with secondary acute myeloid leukemia.

Leuk Lymphoma 2021 Apr 8:1-9. Epub 2021 Apr 8.

Michigan Medicine, Ann Arbor, MI, USA.

Liposomal daunorubicin/cytarabine (CPX-351) gained FDA approval for secondary AML after demonstrating improved outcomes over daunorubicin and cytarabine (7 + 3). A number of study limitations prompted a comparison of safety/efficacy of CPX-351 against regimens containing a purine analogue and high-dose cytarabine (HIDAC). This retrospective study compared complete response rates with/without count recovery (CR/CRi) between HIDAC-based regimens and CPX-351 in 169 patients with newly diagnosed sAML. Read More

View Article and Full-Text PDF

Impact of coronary revascularization on outcomes of transcatheter aortic valve implantation.

Anatol J Cardiol 2021 Apr;25(4):225-235

Department of Cardiology, Medicana International Ankara Hospital; Ankara-Turkey.

Objective: Although the effect of coronary revascularization on clinical outcomes before and after transcatheter valve implantation (TAVI) is debatable, there is currently insufficient data to determine the most appropriate revascularization strategy. In this study, we present our single-center experience of percutaneous coronary intervention (PCI) and its effect on clinical outcomes and mortality in patients undergoing TAVI.

Methods: We performed a retrospective analysis of 526 consecutive patients at our center, and 127 patients with obstructive coronary artery disease were included in the study. Read More

View Article and Full-Text PDF

The UK Foot and Ankle COVID-19 National (FAlCoN) audit.

Bone Jt Open 2021 Apr;2(4):216-226

School of Medicine, University of Liverpool, Liverpool, UK.

Aims: The primary objective was to determine the incidence of COVID-19 infection and 30-day mortality in patients undergoing foot and ankle surgery during the global pandemic. Secondary objectives were to determine if there was a change in infection and complication profile with changes introduced in practice.

Methods: This UK-based multicentre retrospective national audit studied foot and ankle patients who underwent surgery between 13 January and 31 July 2020, examining time periods pre-UK national lockdown, during lockdown (23 March to 11 May 2020), and post-lockdown. Read More

View Article and Full-Text PDF

SARS-CoV-2 infection and H1N1 vaccination: does a relationship between the two factors really exist? A retrospective analysis of a territorial cohort in Ferrara, Italy.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2795-2801

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

Objective: SARS-CoV-2 has been compared with other strains of coronaviruses, SARS-CoV and MERS-CoV, and with the flu viruses: all of them manifest themselves with respiratory symptoms and, although their genetic patterns are similar, the spread of SARS-CoV-2 infection has quickly reached global dimensions, demonstrating that SARS-CoV-2 is a virus with greater spreading capacity, albeit less lethal. Compared with influenza viruses, coronaviruses have a longer incubation period and the patients with coronaviruses' syndromes develop more severe diseases requiring frequent hospitalizations and intensive care admissions. The aim was to explore the relationships between seasonal influenza vaccination and coronavirus infection and to understand whether this hypothetic role by the flu vaccines modifies SARS-CoV-2 infection's outcomes. Read More

View Article and Full-Text PDF

Risk analysis for early mortality in emergency acute type A aortic dissection surgery: experience of Tokyo Acute Aortic Super-network.

Eur J Cardiothorac Surg 2021 Apr 8. Epub 2021 Apr 8.

Tokyo CCU Network Scientific Committee, Tokyo, Japan.

Objectives: We investigated the various pre- and postoperative complications related to early (30-day) mortality after open surgery for acute type A aortic dissection.

Methods: Data from the Tokyo Acute Aortic Super-network database spanning January 2015 to December 2017 were retrospectively reviewed. Pre- and postoperative factors related to early postoperative mortality were assessed in 1504 of 2058 (73. Read More

View Article and Full-Text PDF

The management of displaced femoral neck fractures: a narrative review.

EFORT Open Rev 2021 Feb 1;6(2):139-144. Epub 2021 Feb 1.

Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.

This article serves to review the existing clinical guidelines, and highlight the most recent medical and surgical recommendations, for the management of displaced femoral neck fractures (FNFs). It stresses the need for multi-disciplinary intervention to potentially improve mortality rates, limit adverse events and prevent further economic liability.Globally, the incidence of FNFs continues to rise as the general population ages and becomes more active. Read More

View Article and Full-Text PDF
February 2021

Clinical relevance of emphysema in patients hospitalized with community-acquired pneumonia: clinical features and prognosis.

Clin Respir J 2021 Apr 7. Epub 2021 Apr 7.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Introduction: Few studies have investigated the influence of emphysema on clinical features of patients presenting with community-acquired pneumonia (CAP).

Objectives: The aim of this study was to examine the clinical and microbiological features of patients with both CAP and emphysema.

Methods: This retrospective study included patients with CAP who underwent computed tomography (CT) scan at the time of presentation. Read More

View Article and Full-Text PDF

The influence of the native lung on early outcomes and survival after single lung transplantation.

PLoS One 2021 7;16(4):e0249758. Epub 2021 Apr 7.

Thoracic Surgery and Lung Transplantation Unit, University Hospital Reina Sofia, Cordoba, Spain.

Objective: To determine whether problems arising in the native lung may influence the short-term outcomes and survival after single lung transplantation (SLT), and therefore should be taken into consideration when selecting the transplant procedure.

Patients And Methods: Retrospective review of 258 lung transplants performed between June 2012 and June 2019. Among them, 161 SLT were selected for the analysis. Read More

View Article and Full-Text PDF