Beilstein J Org Chem 2021 17;17:1453-1463. Epub 2021 Jun 17.
Department of Chemistry, Indian Institute of Technology Indore, Khandwa Road, Simrol, Indore-453 552, India.
1,5Disubstituted indole-2-carboxaldehyde derivatives - and glycine alkyl esters - are shown to undergo a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted γ-carbolines - in good yields. The γ-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin, and kidney cancer cells. Read More