25,369 results match your criteria 3'utr


MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training.

Obes Facts 2022 Jan 20:1-13. Epub 2022 Jan 20.

Laboratory of Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.

Obesity is a worldwide epidemic affecting over 13% of the adult population and is defined by an excess of body fat that predisposes comorbidities. It is considered a multifactorial disease in which environmental and genetic factors interact, and it is a risk marker for cardiovascular disease. Lifestyle modifications remain the mainstay of treatment for obesity based on adequate diet and physical exercise. Read More

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January 2022

KHDRBS3 promotes paclitaxel resistance and induces glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial ovarian cancer.

Life Sci 2022 Jan 17:120328. Epub 2022 Jan 17.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. Electronic address:

Paclitaxel (PTX) resistance contributes to mortality in epithelial ovarian cancer (EOC). Aerobic glycolysis is elevated in the tumor environment and may influence resistance to PTX in EOC. KH domain-containing, RNA-binding signal transduction-associated protein 3 (KHDRBS3) is an RNA binding protein that is up-regulated in EOC, but its underlying mechanism in EOC is unclear. Read More

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January 2022

Identification and Characterization of a Garlic Virus E Genome in Garlic ( L.) Using High-Throughput Sequencing from India.

Plants (Basel) 2022 Jan 15;11(2). Epub 2022 Jan 15.

Division of Plant Pathology, ICAR-Indian Agricultural Research Institute, New Delhi 110012, India.

Garlic ( L.) plants exhibiting mosaics, deformation, and yellow stripes symptoms were identified in Meerut City, Uttar Pradesh, India. To investigate the viruses in the garlic samples, the method of high-throughput sequencing (HTS) was used. Read More

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January 2022

[Non-Coding RNA and Innate Immune Signal Regulation].

Sichuan Da Xue Xue Bao Yi Xue Ban 2022 Jan;53(1):20-27

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

The innate immune system is critical to the elimination and control of infections. However, uncontrolled immune responses can cause indirect host-mediated tissue damage. The regulation of immune homeostasis is a complex but finely regulated process. Read More

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January 2022

CircFAM64A enhances cellular processes in triple-negative breast cancer by targeting the miR-149-5p/CDT1 axis.

Environ Toxicol 2022 Jan 20. Epub 2022 Jan 20.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Triple-negative breast cancer (TNBC) is a breast cancer subtype without targeted treatment options. Accumulating evidence has demonstrated the roles of circular RNAs in cancer. This study aimed to investigate the expression and function of circFAM64A in TNBC. Read More

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January 2022

Integrated miRNA and mRNA Expression Profiles Reveal Differentially Expressed miR-222a as an Antiviral Factor Against Duck Hepatitis A Virus Type 1 Infection.

Front Cell Infect Microbiol 2021 3;11:811556. Epub 2022 Jan 3.

College of Veterinary Medicine, Shandong Agricultural University, Taian, China.

Duck hepatitis A virus 1 (DHAV-1) is a highly contagious etiological agent that causes acute hepatitis in young ducklings. MicroRNAs (miRNAs) play important regulatory roles in response to pathogens. However, the interplay between DHAV-1 infection and miRNAs remains ambiguous. Read More

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January 2022

MicroRNAs in Pancreatic Cancer and Chemoresistance.

Pancreas 2021 Nov-Dec 01;50(10):1334-1342

From the State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian, China.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading malignancies affecting human health, largely because of the development of resistance to chemotherapy/radiotherapy. There are many mechanisms that mediate the development of drug resistance, such as the transport of antineoplastic agents into cells, shifts in energy metabolism and environment, antineoplastic agent-induced DNA damage, and genetic mutations. MicroRNAs are short, noncoding RNAs that are 20 to 24 nucleotides in length and serve several biological functions. Read More

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January 2022

Dietary flavonoid narirutin as a prospective antagonist of oncogenic pri/pre-microRNAs.

Phytother Res 2022 Jan 17. Epub 2022 Jan 17.

Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.

MicroRNAs (miRNAs) are involved in cancer progression via translational degradation in a sequence-specific manner of the 3'-untranslated region (3'UTR) of messenger RNA (mRNA). The involvement of miRNA in the biological progression of various cancer types is considered to be a potential target. Primary miRNA (pri-miRNA) and precursor-miRNA (pre-miRNA) synthesize the miRNA by dicer-catalyzed processes thus targeting pri/pre-miRNA by phytochemicals is amongst the appropriate approaches for anticancer therapies. Read More

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January 2022

The NF-κB-regulated miR-221/222/syndecan-1 axis restores intestinal mucosal barrier function in radiation enteritis.

Int J Radiat Oncol Biol Phys 2022 Jan 13. Epub 2022 Jan 13.

Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, West Huanhu Road, West River District, Tianjin 300060, China. Electronic address:

Purpose: Radiation enteritis (RE) is the most common complication of pelvic radiotherapy, but proven therapies are lacking. Barrier function defects are closely associated with numerous inflammatory disorders. In this study, we investigated whether barrier dysfunction contributes to RE and whether syndecan-1 (Sdc1) protects intestinal barrier function in RE. Read More

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January 2022

Genetic Variation in ATXN3 (Ataxin-3) 3'UTR: Insights into the Downstream Regulatory Elements of the Causative Gene of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.

Cerebellum 2022 Jan 16. Epub 2022 Jan 16.

Faculdade de Ciências e Tecnologia, Universidade dos Açores, Ponta Delgada, Portugal.

Untranslated regions are involved in the regulation of transcriptional and post-transcriptional processes. Characterization of these regions remains poorly explored for ATXN3, the causative gene of Machado-Joseph disease (MJD). Although a few genetic modifiers have been identified for MJD age at onset (AO), they only explain a small fraction of the AO variance. Read More

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January 2022

TRIB3 Promotes Osteogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells Levelled by Post-transcriptional Regulation of miR-24-3p.

Chin J Dent Res 2022 Jan;24(4):235-249

Objective: To explore the effect of TRIB3 on the osteogenic differentiation of human adipose-derived mesenchymal stem cells (hASCs) and reveal the potential role of TRIB3 in bone regeneration.

Methods: TRIB3-knockdown and TRIB3-overexpression hASCs were used to explore the effect of TRIB3 on osteogenic differentiation by alkaline phosphatase (ALP) staining, alizarin red S (ARS) staining, quantitative real-time polymerase chain reaction (qRT-PCR) and heterotopic bone formation. The regulation of miR-24-3p on TRIB3 was detected by qRT-PCR and western blot. Read More

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January 2022

hsa-MicroRNA-28-5p Inhibits Diffuse Large B-Cell Lymphoma Cell Proliferation by Downregulating 14-3-3 Expression.

Evid Based Complement Alternat Med 2022 4;2022:4605329. Epub 2022 Jan 4.

Department of Pathology, The Tumor Hospital, Affiliated to Xinjiang Medical University, Xinjiang 830011, China.

MicroRNAs (miRNAs) participate in the comprehensive biological process of several cancer types. In our former study, we found that hsa-microRNA- (miR-)28-5p was downregulated, but tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein zeta (14-3-3 or YWHAZ) was upregulated in diffuse large B-cell lymphoma (DLBCL) tissues. We predicted that YWHAZ was a target gene for hsa-miR- 28-5p using bioinformatics analysis. Read More

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January 2022

MicroRNA-625-3p improved proliferation and involved chemotherapy resistance via targeting PTEN in high grade ovarian serous carcinoma.

J Ovarian Res 2022 Jan 14;15(1). Epub 2022 Jan 14.

Department of Nuclear Medicine, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan, Changchun, 130041, Jilin, People's Republic of China.

Objective: High-grade serous ovarian cancer (HGSOC) is an aggressive gynaecological malignancy and associated with poor prognosis. Here we examined the effects of miR-625-3p on proliferation, treatment, migration and invasion in HGSOC.

Methods: The proliferation of HGSOC cells was evaluated by MTT assay. Read More

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January 2022

A small stem-loop-forming region within the 3'-UTR of a non-polyadenylated LCMV mRNA promotes translation.

J Biol Chem 2022 Jan 10:101576. Epub 2022 Jan 10.

Laboratory of Emerging Viral Diseases, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, 2-8 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

Mammalian arenavirus (mammarenavirus) mRNAs are characterized by 5'-capped and 3'-non-polyadenylated untranslated regions (UTRs). We previously reported that the non-polyadenylated 3'-UTR of viral mRNA (vmRNA), which is derived from the non-coding intergenic region (IGR), regulates viral protein levels at the post-transcriptional level. This finding provided the basis for the development of novel live-attenuated vaccines (LAVs) against human pathogenic mammarenaviruses. Read More

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January 2022

A novel subgenotype C6 Enterovirus A71 originating from the recombination between subgenotypes C4 and C2 strains in mainland China.

Sci Rep 2022 01 12;12(1):593. Epub 2022 Jan 12.

Department of Central Laboratory, The First People's Hospital of Lianyungang, Lianyungang, 222000, Jiangsu, People's Republic of China.

Recombination plays important roles in the genetic diversity and evolution of Enterovirus A71 (EV-A71). The phylogenetics of EV-A71 in mainland China found that one strain DL71 formed a new subgenotype C6 with unknown origin. This study investigated the detailed genetic characteristics of the new variant. Read More

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January 2022

CircMIIP Contributes to Non-Small Cell Lung Cancer Progression by Binding miR-766-5p to Upregulate FAM83A Expression.

Lung 2022 Jan 11. Epub 2022 Jan 11.

Department of Thoracic Surgery, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yungang District, Guiyang, 550004, Guizhou, China.

Background: Circular RNA migration and invasion inhibitory protein (circMIIP) is reported to be upregulated in non-small cell lung cancer (NSCLC) tissues compared with normal tissues. However, the role and working mechanism of circMIIP in NSCLC progression remain largely unclear.

Methods: Cell proliferation ability was analyzed by colony formation assay, cell counting kit-8 (CCK-8) assay, and 5-ethynyl-2'-deoxyuridine assay. Read More

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January 2022

miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy.

Cancer Cell Int 2022 Jan 10;22(1):15. Epub 2022 Jan 10.

Department of Gynecology and Obstetrics, Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Background: Accumulating evidence has revealed that aberrant microRNA (miRNA) expression can affect the development of chemotherapy drug resistance by modulating the expression of relevant target proteins. Emerging evidence has demonstrated that miR-133a participates in the tumorigenesis of various cancers. However, whether miR-133a is associated with cisplatin resistance in ovarian cancer remains unclear. Read More

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January 2022

Circ_0020093 Overexpression Alleviates Interleukin-1 Beta-induced Inflammation, Apoptosis and Extracellular Matrix Degradation in Human Chondrocytes by Targeting the miR-181a-5p/ERG Pathway.

Immunol Invest 2022 Jan 11:1-18. Epub 2022 Jan 11.

Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang City, Hubei Province, China.

Osteoarthritis (OA) is a well-known chronic degenerative joint disease, with multiple changes in the phenotype of chondrocytes. Circular RNAs (circRNAs) have been shown to be involved in various human diseases, including OA. The purpose of this study was to determine the role of circ_0020093 in OA pathological changes in vitro. Read More

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January 2022

Genetic analysis of the postsynaptic transmembrane X-linked neuroligin 3 gene in autism.

Genomics Inform 2021 Dec 31;19(4):e44. Epub 2021 Dec 31.

Laboratory of Vascular Physiology and Medicine, Department of Physiology, Shri B.M Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka 586101, India.

Autism is a complex neurodevelopmental disorder, the prevalence of which has increased drastically in India in recent years. Neuroligin is a type I transmembrane protein that plays a crucial role in synaptogenesis. Alterations in synaptic genes are most commonly implicated in autism and other cognitive disorders. Read More

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December 2021

Altered White Matter and microRNA Expression in a Murine Model Related to Williams Syndrome Suggests That miR-34b/c Affects Brain Development via and Modulation.

Cells 2022 Jan 4;11(1). Epub 2022 Jan 4.

Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.

Williams syndrome (WS) is a multisystem neurodevelopmental disorder caused by a de novo hemizygous deletion of ~26 genes from chromosome 7q11.23, among them the general transcription factor II-I (). By studying a novel murine model for the hypersociability phenotype associated with WS, we previously revealed surprising aberrations in myelination and cell differentiation properties in the cortices of mutant mice compared to controls. Read More

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January 2022

Pax-5 Protein Expression Is Regulated by Transcriptional 3'UTR Editing.

Cells 2021 Dec 28;11(1). Epub 2021 Dec 28.

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada.

The gene encodes a transcription factor that is essential for B-cell commitment and maturation. However, deregulation is associated with various cancer lesions, notably hematopoietic cancers. Mechanistically, studies have characterized genetic alterations within the -5 locus that result in either dominant oncogenic function or haploinsufficiency-inducing mutations leading to oncogenesis. Read More

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December 2021

chi-miR-487b-3p Inhibits Goat Myoblast Proliferation and Differentiation by Targeting IRS1 through the IRS1/PI3K/Akt Signaling Pathway.

Int J Mol Sci 2021 Dec 23;23(1). Epub 2021 Dec 23.

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs and play critical roles in the regulation of post-transcriptional gene expression. Our previous study uncovered that chi-miR-487b-3p is widespread in different goat tissues, which is significantly higher in muscle, especially in lamb. Here, we demonstrate the role of chi-miR-487b-3p as a myogenic miRNA that regulates skeletal muscle development. Read More

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December 2021

MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells.

Int J Mol Sci 2021 Dec 21;23(1). Epub 2021 Dec 21.

Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan.

The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of microRNAs in regulating the expression of key pluripotency factors, we performed a genome-wide analysis of microRNA expression in the embryonal carcinoma cell line NT2/D1 in the presence of the PKC activator, PMA. Read More

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December 2021

Human Cytomegalovirus miR-UL70-3p Downregulates the HO-Induced Apoptosis by Targeting the Modulator of Apoptosis-1 (MOAP1).

Int J Mol Sci 2021 Dec 21;23(1). Epub 2021 Dec 21.

Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India.

Human Cytomegalovirus (HCMV) is a prototypic , causing persistent infections in humans. There are medications that are used to treat the symptoms; however, there is no cure yet. Thus, understanding the molecular mechanisms of HCMV replication and its persistence may reveal new prevention strategies. Read More

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December 2021

Knockdown of lncRNA CCAT1 Inhibits the Progression of Colorectal Cancer via hsa-miR-4679 Mediating the Downregulation of GNG10.

J Immunol Res 2021 30;2021:8930813. Epub 2021 Dec 30.

Department of Surgery, School of Clinical Medicine, Dali University, Dali, Yunnan 671000, China.

Great concerns have raised crucial roles of long noncoding RNAs (lncRNAs) on colorectal cancer progression due to the increasing number of studies in cancer development. Previous studies reveal that lncRNA CCAT1 plays an important role in the progression of a variety of cancers. However, the role of lncRNA CCAT1 in colorectal cancer is still unclear. Read More

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December 2021

Transcriptome-Wide m6A Analysis Provides Novel Insights Into Testicular Development and Spermatogenesis in Xia-Nan Cattle.

Front Cell Dev Biol 2021 22;9:791221. Epub 2021 Dec 22.

Guangxi Provincial Key Laboratory of Buffalo Genetics, Breeding and Reproduction Technology, Buffalo Research Institute, Chinese Academy of Agricultural Sciences, Nanning, China.

Testis is the primary organ of the male reproductive tract in mammals that plays a substantial role in spermatogenesis. Improvement of our knowledge regarding the molecular mechanisms in testicular development and spermatogenesis will be reflected in producing spermatozoa of superior fertility. Evidence showed that N6-Methyladenosine (m6A) plays a dynamic role in post-transcription gene expression regulation and is strongly associated with production traits. Read More

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December 2021

MicroRNA-603 Promotes Progression of Cutaneous Melanoma by Regulating TBX5.

Comput Math Methods Med 2021 31;2021:1888501. Epub 2021 Dec 31.

Department of Dermatology, 970 Hospital of The PLA Joint Logistic Support Force, Yantai 264010, China.

Background: Although studies manifested that microRNA-603 plays a vital role in many cancers, the modulatory mechanism of microRNA-603 in cutaneous melanoma remains unknown. We aimed to investigate the roles of microRNA-603 in cutaneous melanoma cells.

Methods: First, microRNA-603 expression in cutaneous melanoma cell lines was detected by qRT-PCR. Read More

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December 2021

RNA -methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice.

Elife 2022 Jan 10;11. Epub 2022 Jan 10.

Tianjin Medical University General Hospital Cardiovascular Department, Tianjin Medical University, Tianjin, China.

Atherosclerosis preferentially occurs in atheroprone vasculature where human umbilical vein endothelial cells (HUVECs) are exposed to disturbed flow. Disturbed flow is associated with vascular inflammation and focal distribution. Recent studies have revealed the involvement of epigenetic regulation in atherosclerosis progression. Read More

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January 2022

MiR-141-3p regulates myogenic differentiation in C2C12 myoblasts via CFL2-YAP-mediated mechanotransduction.

BMB Rep 2022 Jan 10. Epub 2022 Jan 10.

Department of Biochemistry, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju 38066, Republic of Korea.

Skeletal myogenesis is essential to keep muscle mass and integrity, and impaired myogenesis is closely related to the etiology of muscle wasting. Recently, miR-141-3p has been shown to be induced under various conditions associated with muscle wasting, such as aging, oxidative stress, and mitochondrial dysfunction. However, the functional significance and mechanism of miR-141-3p in myogenic differentiation have not been explored to date. Read More

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January 2022

MiR-556-5p modulates migration, invasion, and epithelial-mesenchymal transition in breast cancer cells via targeting PTHrP.

J Mol Histol 2022 Jan 9. Epub 2022 Jan 9.

Department of Surgery, Changsha Hospital for Maternal and Child Health Care, No. 416 Chengnan East Road, Yuhua District, Changsha, 410007, Hunan, China.

Breast cancer bone metastases may block normal bone remodeling and promote bone degradation, during which several signaling pathways and small non-coding miRNAs might all play a role. miRNAs and target mRNAs that might be associated with breast cancer bone metastasis were analyzed and selected using bioinformatics analyses based on online data. The 3' untranslated region of key factors associated with breast cancer metastasis were examined for candidate miRNA binding site using Targetscan. Read More

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January 2022