J Biol Chem 2022 Jan 10:101576. Epub 2022 Jan 10.
Laboratory of Emerging Viral Diseases, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, 2-8 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:
Mammalian arenavirus (mammarenavirus) mRNAs are characterized by 5'-capped and 3'-non-polyadenylated untranslated regions (UTRs). We previously reported that the non-polyadenylated 3'-UTR of viral mRNA (vmRNA), which is derived from the non-coding intergenic region (IGR), regulates viral protein levels at the post-transcriptional level. This finding provided the basis for the development of novel live-attenuated vaccines (LAVs) against human pathogenic mammarenaviruses. Read More