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Expanding the Donor Pool: First Use of Hepatitis B Virus Nat Positive Solid Organ Allografts Into Seronegative Recipients.

Ann Surg 2021 10;274(4):556-564

Cincinnati Research in Outcomes and Safety in Surgery (CROSS) Research Group, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.

Objectives: The aim of this study was to assess the 1-year safety and effectiveness of HBV Nucleic Acid Test positive (HBV NAT+) allografts in seronegative kidney transplant (KT) and liver transplant (LT) recipients.

Summary Background Data: Despite an ongoing organ shortage, the utilization of HBV NAT+ allografts into seronegative recipients has not been investigated.

Methods: From January 2017 to October 2020, a prospective cohort study was conducted among consecutive KT and LT recipients at a single institution. Read More

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October 2021

Effect of Clozapine on Time Assigned to Restrictive Housing in a State Prison Population.

J Am Acad Psychiatry Law 2021 Sep 3. Epub 2021 Sep 3.

Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC. Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC. North Carolina Department of Public Safety - Prisons, Raleigh, NC.

This study examined the effect of clozapine on time assigned to restrictive housing (RH; i.e., solitary confinement), disciplinary infractions, and assaults on custody staff among patients treated within the North Carolina prison system. Read More

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September 2021

Routine early postoperative computed tomography angiography after coronary artery bypass surgery: clinical value and management implications.

Eur J Cardiothorac Surg 2021 Aug 19. Epub 2021 Aug 19.

Clinic for Cardiac Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Objectives: Computed tomography angiography (CTA) is broadly used for long-term follow-up of graft patency after coronary artery bypass graft surgery (CABG). However, its clinical value in the early postoperative setting has not been established yet. We evaluated the benefit of adding CTA to the routine clinical work-up after CABG on patient management. Read More

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Feasibility of Distal Radial Access for Coronary Angiography and Percutaneous Coronary Intervention: A Single Center Experience.

Cardiology 2021 Aug 6:1-7. Epub 2021 Aug 6.

Cardiology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

Objective: Asymptomatic radial artery occlusion remains the most common complication in transradial coronary interventional procedure. To prevent radial artery occlusion, distal transradial access (dTRA) has been suggested recently. In this article, we aim to describe our experience and to assess feasibility and safety of this new access site for routine coronary angiography (CAG) and percutaneous coronary intervention (PCI). Read More

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Difference between morning and evening home blood pressure and cardiovascular events: the J-HOP Study (Japan Morning Surge-Home Blood Pressure).

Hypertens Res 2021 Jul 28. Epub 2021 Jul 28.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

Little is known about the relationship of the difference between morning and evening systolic blood pressure (BP) (MEdif) in home BP with cardiovascular disease (CVD) incidence. To assess this relationship, we used data from the nationwide practice-based J-HOP (Japan Morning Surge-Home BP) study, which recruited 4258 cardiovascular risk participants (mean age 64.9 years; 46. Read More

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Chitosan as capping agent in a robust one-pot procedure for a magnetic catalyst synthesis.

Carbohydr Polym 2021 Oct 31;269:118267. Epub 2021 May 31.

Indiana University, Department of Chemistry, 800 E. Kirkwood Av., Bloomington, IN 47408, USA; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov St., Moscow 119991, Russian Federation; King Abdulaziz University, Faculty of Science, Department of Physics, Jeddah 21589, Saudi Arabia. Electronic address:

Here, we report a one-pot solvothermal method for the development of magnetically recoverable catalysts with Ru or Ag nanoparticles (NPs) capped by chitosan (CS), a derivative of natural chitin. The formation of iron oxide NPs was carried out in situ in the presence of CS and iron acetylacetonate in boiling triethyleneglycol (TEG) due to CS solubilization in warm TEG. Coordination with Ru or Ag species and the NP formation take place in the same reaction solution, eliminating intermediate steps. Read More

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October 2021

Chitosan immobilization and FeO functionalization of olive pomace: An eco-friendly and recyclable Pb biosorbent.

Carbohydr Polym 2021 Oct 31;269:118266. Epub 2021 May 31.

Department of Chemistry, Faculty of Science and Letters, Eskisehir Osmangazi University, TR-26040 Eskisehir, Turkey.

An effective and sustainable biosorbent (MagOPIC) was prepared from chitosan and olive pomace by the combined action of immobilization and magnetic modification to remediate Pb-contaminated waters. Pb sorption yield at the end of the equilibrium (45 min) period was estimated to be 98.56 ± 0. Read More

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October 2021

The lower threshold of hypothermic oxygen delivery to prevent neonatal acute kidney injury.

Pediatr Res 2021 Jul 17. Epub 2021 Jul 17.

Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Oxygen delivery during cardiopulmonary bypass (CPB) is closely related to postoperative acute kidney injury (AKI). The value of critical indexed oxygen delivery (DOi) is a key indicator to reflect oxygen supply in cardiovascular surgery. However, the target DOi value for neonates undergoing hypothermic CPB remains unclear. Read More

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Transition from esophagectomy to endoscopic therapy for early esophageal cancer.

Dis Esophagus 2021 Jul 15. Epub 2021 Jul 15.

Esophago-Gastric Surgery, Guy's and St.Thomas' Esophago-Gastric Centre, London UK.

Background: To assess the outcomes of patients with early esophageal cancer and high-grade dysplasia comparing esophagectomy, the historical treatment of choice, to endoscopic eradication therapy (EET).

Methods: Retrospective cohort study of consecutive patients with early esophageal cancer/high-grade dysplasia, treated between 2000 and 2018 at a tertiary center. Primary outcomes were all-cause and disease-specific mortality assessed by multivariable Cox regression and a propensity score matching sub analysis, providing hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, tumor grade (G1/2 vs. Read More

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The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study.

Lancet Rheumatol 2021 Sep 8;3(9):e627-e637. Epub 2021 Jul 8.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, King's College London, London, UK.

Background: Patients on therapeutic immunosuppressants for immune-mediated inflammatory diseases were excluded from COVID-19 vaccine trials. We therefore aimed to evaluate humoral and cellular immune responses to COVID-19 vaccine BNT162b2 (Pfizer-BioNTech) in patients taking methotrexate and commonly used targeted biological therapies, compared with healthy controls. Given the roll-out of extended interval vaccination programmes to maximise population coverage, we present findings after the first dose. Read More

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September 2021

Post-operative Opioid, Benzodiazepine and Sedative Usage in Medicare versus Commercial Insurance Hand Surgery Patients.

Arch Bone Jt Surg 2021 May;9(3):319-322

The Rothman Institute, Hand and Upper Extremity Surgery, Philadelphia, PA, USA.

Background: Opioid usage has increased in recent years. The purpose of this study is to assess post-operative opioid, sedative, and benzodiazepine usage in a Medicare population.

Methods: Consecutive patients undergoing elbow, wrist, and hand surgery by hand surgeons at one academic outpatient surgical center were prospectively enrolled. Read More

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Clinical characteristics of .

Nagoya J Med Sci 2021 May;83(2):269-276

Department of General Medicine, Nagoya University Hospital, Nagoya, Japan.

was first reported in 2000. Its characteristics such as isolation frequency, specimen types, and antimicrobial susceptibilities are poorly understood, because identification is difficult using conventional methods. We performed a retrospective observational study of 13 and 317 strains of and , respectively, isolated from consecutive patients at Nagoya University Hospital from January 2017 to December 2018. Read More

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Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness.

Crit Care 2021 07 7;25(1):240. Epub 2021 Jul 7.

Department of Anaesthesiology and Intensive Care, CLINTEC, Karolinska Institutet and Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge Stockholm, B31 Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden.

Background: A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequently reported, the number of patients with hyperglutaminemia has so far been quite few. Therefore, the association between hyperglutaminemia and mortality outcomes was studied in a prospective, observational study. Read More

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Utility of compression immediately after venous closure: Does it matter?

Phlebology 2021 Jul 2:2683555211028533. Epub 2021 Jul 2.

Division of Vascular Surgery, the Mount Sinai Hospital, New York, NY, USA.

Background: Leg compression after venous closures for 24-48 hours or longer is commonplace and controversial.

Objective: The goal of our study was to evaluate compression immediately post-venous closures and its associated costs.

Methods: Records were retrospectively reviewed after consecutive therapies of sclerotherapy, mechanochemical ablation (MOCA) & radiofrequency ablation (RFA) from 1 clinic with 2 cohorts: 7/2/13-10/15/15 were immediately ACE-wrapped for 3-5 days (AW, N = 52) and 10/20/15-1/5/16 were non ACE-wrapped (NAW, N = 49). Read More

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Vanishing pachy-choroid in pachychoroid neovasculopathy under long-term anti-vascular endothelial growth factor therapy.

BMC Ophthalmol 2021 Jun 30;21(1):269. Epub 2021 Jun 30.

Department of Ophthalmology, Ludwig-Maximilians-University, Mathildenstrasse 8, 80336, Munich, Germany.

Background: To investigate the diagnostic value of choroidal thickness in the definition of pachychoroid neovasculopathy (PNV), especially in eyes treated with anti-vascular endothelial growth factor (VEGF) therapy.

Methods: Twenty-two consecutive eyes of 11 patients with uni- or bilateral PNV were analyzed. Anti-VEGF treatment was correlated with changes in choroidal thickness on enhanced depth imaging optical coherence tomography. Read More

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Left Atrial Strain to Predict Stroke in Patients With Acute Heart Failure and Sinus Rhythm.

J Am Heart Assoc 2021 Jul 30;10(13):e020414. Epub 2021 Jun 30.

Cardiovascular Center & Department of Internal Medicine Seoul National University College of MedicineSeoul National University Bundang Hospital Seongnam Korea.

Background Stroke is a major comorbidity in patients with heart failure (HF), especially in those with decreased left atrial (LA) function, and thus, identifying patients highly at risk of stroke can prevent its occurrence. We evaluated the predictive value of global longitudinal strain of LA (LAGLS) in patients with acute HF and sinus rhythm. Methods and Results In this retrospective study, 2461 patients (53. Read More

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Management of spaghetti wrist under WALANT technique.

Hand Surg Rehabil 2021 Jun 21. Epub 2021 Jun 21.

Antalya Training and Research Hospital, Department of Orthopedics and Traumatology, Soguksu District, Kazım Karabekir Street, Muratpasa, 07100, Antalya, Turkey. Electronic address:

This study aimed to evaluate the effectiveness of the WALANT technique in managing spaghetti wrist lacerations. Thirteen consecutive patients with spaghetti wrist laceration were operated on under WALANT technique and followed prospectively. All patients were operated on by the same hand surgeon in a university hospital setting. Read More

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Does Nonalcoholic Pancreatic Steatosis Always Correlate with Nonalcoholic Fatty Liver Disease?

Clin Exp Gastroenterol 2021 11;14:269-275. Epub 2021 Jun 11.

Department of Gastroenterology, Medeniyet University, Goztepe Education and Research Hospital, Istanbul, Turkey.

Purpose: To identify the correlation of nonalcoholic pancreatic steatosis (NAPS) with nonalcoholic fatty liver disease (NAFLD) in an outpatient group. Based on its metabolic and imaging properties, NAPS has been increasingly recognized in recent years; however, its interaction with NAFLD is still not clear.

Patients And Methods: In this cross-sectional observational study, 345 consecutive patients without any chronic illness who were referred to the senior radiologist for abdominal ultrasound (US) were included. Read More

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Cholinergic hyperactivity in patients with myasthenia gravis with MuSK antibodies: A neurophysiological study.

Clin Neurophysiol 2021 Aug 1;132(8):1845-1849. Epub 2021 Jun 1.

Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Largo A. Gemelli, 8 - 00168 Rome, Italy; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo F. Vito, 1 - 00168 Rome, Italy.

Objective: Patients with myasthenia gravis associated with muscle-specific tyrosine kinase antibodies (MuSK-MG) often manifest signs of cholinergic hyperactivity with standard doses of acetylcholinesterase inhibitors (AChE-Is). Aim of the study was to investigate whether repetitive compound muscle action potential (R-CMAP), the neurophysiological correlate of cholinergic hyperactivity, was present in MuSK-MG irrespective of AChE-I treatment.

Methods: Patients with confirmed diagnosis of MuSK-MG were consecutively enrolled during follow-up visits, from January 2019 to April 2020. Read More

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Dynamics of Matrix Metalloproteinase-1 and -8 Secretion in Gingival Crevicular Fluid after Gingival Recession Therapy via MCAT with Either Subepithelial Connective Tissue Graft or Collagen Matrix.

Biomolecules 2021 05 14;11(5). Epub 2021 May 14.

Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. aszyngtona 13, 15-269 Białystok, Poland.

Objectives: The objective of this study was to determine and estimate the changing levels of matrix metalloproteinases 1 and 8 (MMP-1 and MMP-8) in GCF at consecutive stages of healing after root coverage procedure via modified coronally advanced tunnel (MCAT) combined with either sub-epithelial connective tissue graft (SCTG) or collagen matrix (CM) and also to relate those changes to clinical outcomes of both therapeutic approaches.

Materials And Methods: The study involved 20 patients with a total of 91 recessions. Those on one side of the mandible received MCAT plus CM while the contralateral ones MCAT plus SCTG. Read More

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Outcomes of Hepatic Resection for Hepatocellular Carcinoma Associated with Portal Vein Invasion.

J Surg Res 2021 10 24;266:269-283. Epub 2021 May 24.

Gastrointestinal Surgery Center, Department of Surgery, College of Medicine, Mansoura University, Mansoura, Egypt.

Background: To evaluate our experience of liver resection for hepatocellular carcinoma (HCC) patients associated with macroscopic portal vein invasion (PVI).

Methods: Consecutive HCC patients who underwent liver resection for HCC between November 2009 & June 2019 were included. To overcome selection bias between patients with and without macroscopic PVI, we performed 1:1 match using propensity score matching (PSM). Read More

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October 2021

A Prospective Evaluation of the Acute Effects of High Altitude on Cognitive and Physiological Functions in Lowlanders.

Front Physiol 2021 28;12:670278. Epub 2021 Apr 28.

Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy.

Cognitive function impairment due to high altitude exposure has been reported with some contradictory results regarding the possible selective cognitive domain involvement. We prospectively evaluated in 36 lowlanders, exposed for 3 consecutive days to an altitude of 3,269 m, specific cognitive abilities (attention, processing speed, and decision-making) required to safely explore the mountains, as well as to work at altitude. We simultaneously monitored the physiological parameters. Read More

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Reconstruction in Women with T4 Breast Cancer after Neoadjuvant Chemotherapy: When Is It Safe?

J Am Coll Surg 2021 Aug 3;233(2):285-293. Epub 2021 May 3.

Breast Service. Electronic address:

Background: Despite limited evidence regarding its safety, immediate reconstruction (IR) is increasingly offered to women with T4 breast cancer. We compared outcomes after IR, delayed reconstruction (DR), and no reconstruction (NR) in patients treated with neoadjuvant chemotherapy (NAC) and postmastectomy radiation therapy (PMRT) for T4 disease.

Study Design: We retrospectively identified consecutive women with T4 tumors treated with trimodality therapy from January 2007 through December 2019. Read More

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Predictors of stillbirth among women who had given birth in Southern Ethiopia, 2020: A case-control study.

PLoS One 2021 3;16(5):e0249865. Epub 2021 May 3.

Department of Midwifery, College of Health Sciences and Medicine, Wolkite University, Wolkite, Ethiopia.

Background: Although the rate of stillbirth has decreased globally, it remains unacceptably high in low- and middle-income countries. Only ten countries including Ethiopia attribute more than 65% of global burden of still birth. Ethiopia has the 7th highest still birth rate in the world. Read More

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Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis.

Clin Imaging 2021 Apr 28;79:104-109. Epub 2021 Apr 28.

Department of Medical Microbiology, Gulhane Medical Faculty, University of Health Sciences, Ankara, Turkey.

Purpose: To radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in COVID-19.

Methods: Between July 1 and August 31, 2020, consecutive patients diagnosed with COVID-19 were analyzed. Among these patients, those who underwent chest computed tomography (CT) examination at the time of presentation, patients with follow-up CT due to clinical deterioration were included in the study. Read More

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Combination of long- and short-axis alar sacroplasty techniques under fluoroscopic guidance for osteoporotic sacral insufficiency fracture.

J Orthop Surg Res 2021 Apr 17;16(1):269. Epub 2021 Apr 17.

Department of Orthopedics, E-Da Hospital, Kaohsiung, Taiwan.

Background: Sacral insufficiency fracture (SIF) is rarer than osteoporotic vertebral compression fracture that occurs at other levels of the thoracolumbar spine. Percutaneous sacroplasty can effectively relieve pain and improve mobility. Several sacroplasty-based techniques have been reported to date. Read More

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Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection.

BMC Cancer 2021 Apr 7;21(1):372. Epub 2021 Apr 7.

The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.

Background: Oral squamous cell carcinoma (OSCC) is the dominant histologic type of oral cancer. Locally advanced OSCC remains a major therapeutic challenge. Our study aimed to develop and validate nomograms predicting survival prognosis in patients with locally advanced oral squamous cell carcinoma (OSCC) after curative resection. Read More

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How did three consecutive matches with extra time affect physical performance? A case study of the 2018 football Men's World Cup.

Biol Sport 2021 Mar 21;38(1):65-70. Epub 2020 Aug 21.

Department of Methodology of Recreation, Poznań University School of Physical Education, Poznań, Poland.

The purpose of this study was to ascertain the effect of playing three consecutive matches with extra time (ET) on the physical performance of selected Croatian players in their subsequent match, the final of the 2018 Men's World Cup in Russia. The case study consisted of 4 players on the Croatian national team (16 observations) who had played in all three matches up to 120 min. The consecutive full time matches (90 minutes) and extra time (30 minutes) were compared. Read More

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Eruptive Calcified Nodules as a Potential Mechanism of Acute Coronary Thrombosis and Sudden Death.

J Am Coll Cardiol 2021 Apr;77(13):1599-1611

CVPath Institute, Gaithersburg, Maryland, USA. Electronic address:

Background: Calcified nodule (CN) has a unique plaque morphology, in which an area of nodular calcification causes disruption of the fibrous cap with overlying luminal thrombus. CN is reported to be the least frequent cause of acute coronary thrombosis, and the pathogenesis of CN has not been well studied.

Objectives: The purpose of this study is to provide a comprehensive morphologic assessment of the CN in addition to providing an evolutionary perspective as to how CN causes acute coronary thrombosis in patients with acute coronary syndromes. Read More

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Diastolic and Systolic Cardiac Dysfunction in Pectus Excavatum: Relationship to Exercise and Malformation Severity.

Radiol Cardiothorac Imaging 2020 Oct 15;2(5):e200011. Epub 2020 Oct 15.

Department of Cardiology, Clínica Olivos, Buenos Aires, Argentina (I.M.R.); Department of Cardiology, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina (I.M.R., M.M.); Department of Surgery, Fundación Hospitalaria, Private Children's Hospital, Buenos Aires, Argentina (M.M.F., G.B.M., L.T.); Department of Cardiovascular Imaging, Diagnostico Maipú, Av. Maipú 1668, Vicente López, Buenos Aires, Argentina (C.C., P.C., G.A.R.G.); and Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina (G.A.R.G.).

Purpose: To explore stress echocardiographic findings among patients with pectus excavatum (PEX) and their relationship with malformation severity.

Materials And Methods: A prospective registry involving consecutive patients with a diagnosis of isolated PEX referred to undergo chest CT and stress echocardiography to evaluate surgical candidacy and/or to define treatment strategies was developed. Malformation indexes were evaluated using chest CT. Read More

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October 2020